locus-tag	class	description
I6L39_00005	COG0577	efflux transmembrane transporter activity
I6L39_00010	COG0577	efflux transmembrane transporter activity
I6L39_00010	COG1136	(ABC) transporter
I6L39_00055	COG1285	pathogenesis
I6L39_00085	COG0484	heat shock protein binding
I6L39_00090	COG0443	Heat shock 70 kDa protein
I6L39_00095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L39_00100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L39_00105	COG0497	DNA recombination
I6L39_00110	COG1227	inorganic diphosphatase activity
I6L39_00120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_00125	COG1136	(ABC) transporter
I6L39_00125	COG0577	efflux transmembrane transporter activity
I6L39_00130	COG1538	Outer membrane efflux protein
I6L39_00135	COG2375	cellular response to nickel ion
I6L39_00140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L39_00145	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L39_00150	COG0583	DNA-binding transcription factor activity
I6L39_00155	COG3048	D-serine ammonia-lyase activity
I6L39_00165	COG0538	isocitrate dehydrogenase activity
I6L39_00195	COG0456	acetyltransferase
I6L39_00200	COG1187	pseudouridine synthase activity
I6L39_00210	COG0482	sulfurtransferase activity
I6L39_00215	COG2915	High frequency lysogenization protein hflD homolog
I6L39_00220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L39_00225	COG2850	peptidyl-arginine hydroxylation
I6L39_00235	COG1196	nuclear chromosome segregation
I6L39_00235	COG3264	Mechanosensitive ion channel
I6L39_00260	COG2233	PERMEase
I6L39_00265	COG0281	malic enzyme
I6L39_00270	COG0746	molybdenum cofactor guanylyltransferase activity
I6L39_00275	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6L39_00315	COG4319	ketosteroid isomerase
I6L39_00335	COG4319	ketosteroid isomerase
I6L39_00340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L39_00345	COG0083	homoserine kinase activity
I6L39_00355	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L39_00360	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L39_00375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L39_00385	COG0745	RESPONSE REGULATOR receiver
I6L39_00400	COG4988	ABC transporter
I6L39_00405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L39_00425	COG1720	tRNA m6t6A37 methyltransferase activity
I6L39_00440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L39_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L39_00450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_00460	COG2190	(PTS) system
I6L39_00475	COG2814	Major facilitator Superfamily
I6L39_00480	COG0778	Nitroreductase
I6L39_00490	COG0420	3'-5' exonuclease activity
I6L39_00495	COG0456	acetyltransferase
I6L39_00500	COG2974	May be involved in recombination
I6L39_00505	COG0583	DNA-binding transcription factor activity
I6L39_00510	COG0477	Major facilitator Superfamily
I6L39_00525	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L39_00525	COG4651	solute:proton antiporter activity
I6L39_00530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L39_00535	COG1917	Cupin 2, conserved barrel domain protein
I6L39_00535	COG1396	sequence-specific DNA binding
I6L39_00540	COG1012	belongs to the aldehyde dehydrogenase family
I6L39_00555	COG0531	amino acid
I6L39_00560	COG0531	amino acid
I6L39_00570	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L39_00580	COG3384	dioxygenase
I6L39_00585	COG2205	protein histidine kinase activity
I6L39_00585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_00610	COG0784	Response regulator, receiver
I6L39_00610	COG2205	protein histidine kinase activity
I6L39_00640	COG1376	ErfK ybiS ycfS ynhG family protein
I6L39_00640	COG1388	LysM domain
I6L39_00655	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L39_00660	COG0791	NLP P60 protein
I6L39_00670	COG3118	belongs to the thioredoxin family
I6L39_00680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L39_00685	COG0788	formyltetrahydrofolate deformylase activity
I6L39_00710	COG1196	nuclear chromosome segregation
I6L39_00710	COG0741	lytic transglycosylase activity
I6L39_00710	COG0739	heme binding
I6L39_00715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L39_00720	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L39_00725	COG0673	inositol 2-dehydrogenase activity
I6L39_00745	COG1032	radical SAM domain protein
I6L39_00750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_00760	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L39_00765	COG0733	neurotransmitter:sodium symporter activity
I6L39_00795	COG0281	malic enzyme
I6L39_00805	COG0534	Mate efflux family protein
I6L39_00820	COG2233	PERMEase
I6L39_00825	COG0095	Lipoate-protein ligase
I6L39_00830	COG1115	amino acid carrier protein
I6L39_00835	COG0019	diaminopimelate decarboxylase activity
I6L39_00850	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L39_00860	COG1126	abc transporter atp-binding protein
I6L39_00865	COG0765	amino acid transport
I6L39_00870	COG4597	amino acid ABC transporter
I6L39_00875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_00890	COG1131	(ABC) transporter
I6L39_00895	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L39_00915	COG3142	Participates in the control of copper homeostasis
I6L39_00940	COG5002	protein histidine kinase activity
I6L39_00945	COG0745	RESPONSE REGULATOR receiver
I6L39_00950	COG0346	lactoylglutathione lyase activity
I6L39_00955	COG3706	GGDEF domain
I6L39_00960	COG3284	Transcriptional regulator
I6L39_00975	COG0697	spore germination
I6L39_00985	COG3290	protein histidine kinase activity
I6L39_00990	COG0281	malic enzyme
I6L39_01005	COG1566	PFAM secretion protein HlyD family protein
I6L39_01030	COG0602	queuosine metabolic process
I6L39_01035	COG1328	CTP reductase activity
I6L39_01045	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L39_01050	COG3115	cell septum assembly
I6L39_01055	COG1196	nuclear chromosome segregation
I6L39_01065	COG2860	membrane
I6L39_01075	COG3108	Peptidase M15
I6L39_01080	COG2989	Protein conserved in bacteria
I6L39_01095	COG0463	Glycosyl transferase, family 2
I6L39_01110	COG0366	Alpha amylase catalytic
I6L39_01145	COG3706	GGDEF domain
I6L39_01150	COG0037	tRNA processing
I6L39_01155	COG3590	peptidase
I6L39_01165	COG0531	amino acid
I6L39_01170	COG0814	amino acid
I6L39_01175	COG0583	DNA-binding transcription factor activity
I6L39_01185	COG1982	Orn Lys Arg decarboxylase major
I6L39_01190	COG0531	amino acid
I6L39_01195	COG3710	Transcriptional regulator
I6L39_01200	COG0825	malonyl-CoA metabolic process
I6L39_01210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L39_01215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L39_01220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L39_01225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L39_01230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L39_01245	COG0750	zinc metalloprotease
I6L39_01250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L39_01255	COG0575	Belongs to the CDS family
I6L39_01260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L39_01265	COG0233	cytoplasmic translational termination
I6L39_01270	COG0528	UMP kinase activity
I6L39_01275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L39_01280	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L39_01285	COG0024	Methionine aminopeptidase
I6L39_01290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6L39_01295	COG2171	N-acyltransferase activity
I6L39_01325	COG0564	pseudouridine synthase activity
I6L39_01330	COG3098	single-species biofilm formation
I6L39_01355	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L39_01365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L39_01365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L39_01380	COG1611	Belongs to the LOG family
I6L39_01385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L39_01390	COG0473	3-isopropylmalate dehydrogenase activity
I6L39_01400	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L39_01405	COG2363	Small membrane protein
I6L39_01415	COG0583	DNA-binding transcription factor activity
I6L39_01420	COG0840	transmembrane signaling receptor activity
I6L39_01425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L39_01440	COG1477	protein flavinylation
I6L39_01445	COG2871	sodium ion transport
I6L39_01450	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L39_01455	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L39_01460	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L39_01465	COG1805	sodium ion transport
I6L39_01470	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L39_01475	COG0271	Belongs to the BolA IbaG family
I6L39_01480	COG2813	Specifically methylates the guanine in position
I6L39_01490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L39_01500	COG2211	Major facilitator Superfamily
I6L39_01510	COG1666	GTP binding
I6L39_01525	COG1393	Belongs to the ArsC family
I6L39_01530	COG0798	PFAM Bile acid sodium symporter
I6L39_01540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L39_01560	COG0640	Transcriptional regulator
I6L39_01575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L39_01580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L39_01585	COG1151	hydroxylamine reductase activity
I6L39_01590	COG0783	Belongs to the Dps family
I6L39_01615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L39_01630	COG0300	oxidoreductase activity
I6L39_01640	COG0415	Belongs to the DNA photolyase family
I6L39_01645	COG0789	Transcriptional regulator
I6L39_01650	COG3272	Protein of unknown function (DUF1722)
I6L39_01675	COG1605	Chorismate mutase
I6L39_01675	COG0077	Prephenate dehydratase
I6L39_01710	COG2133	pyrroloquinoline quinone binding
I6L39_01720	COG1349	DNA-binding transcription factor activity
I6L39_01725	COG2084	Dehydrogenase
I6L39_01730	COG3395	kinase activity
I6L39_01735	COG0235	Class ii aldolase
I6L39_01740	COG3622	Belongs to the hyi family
I6L39_01745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L39_01750	COG2610	gluconate transmembrane transporter activity
I6L39_01760	COG0840	transmembrane signaling receptor activity
I6L39_01770	COG0300	oxidoreductase activity
I6L39_01795	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L39_01805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L39_01815	COG3813	Protein conserved in bacteria
I6L39_01825	COG0826	peptidase U32
I6L39_01830	COG1280	lysine exporter protein (LysE YggA)
I6L39_01840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L39_01875	COG3275	phosphorelay sensor kinase activity
I6L39_01880	COG3279	Response regulator of the LytR AlgR family
I6L39_01885	COG1966	Carbon starvation protein
I6L39_01910	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I6L39_01925	COG4263	nitrous-oxide reductase activity
I6L39_01930	COG0348	domain, Protein
I6L39_01930	COG3901	Regulator of nitric oxide reductase transcription
I6L39_01935	COG0114	fumarate hydratase activity
I6L39_01945	COG0506	proline dehydrogenase activity
I6L39_01945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L39_01945	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6L39_01950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L39_01965	COG0737	Belongs to the 5'-nucleotidase family
I6L39_01985	COG2204	response regulator
I6L39_01990	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L39_02000	COG2900	Belongs to the SlyX family
I6L39_02005	COG1047	Peptidyl-prolyl cis-trans
I6L39_02010	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L39_02020	COG0784	Response regulator, receiver
I6L39_02020	COG0835	chemotaxis
I6L39_02025	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L39_02030	COG2203	Gaf domain
I6L39_02030	COG3706	GGDEF domain
I6L39_02030	COG4251	negative regulation of phosphorylation
I6L39_02030	COG5001	Diguanylate cyclase
I6L39_02035	COG3089	Belongs to the UPF0270 family
I6L39_02040	COG3954	Phosphoribulokinase
I6L39_02055	COG1765	OsmC-like protein
I6L39_02065	COG2226	methyltransferase
I6L39_02085	COG2205	protein histidine kinase activity
I6L39_02090	COG2814	Major facilitator Superfamily
I6L39_02115	COG0748	coenzyme F420 binding
I6L39_02120	COG3721	Heme iron utilization protein
I6L39_02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L39_02155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L39_02165	COG0463	Glycosyl transferase, family 2
I6L39_02170	COG0739	heme binding
I6L39_02170	COG0741	lytic transglycosylase activity
I6L39_02170	COG1196	nuclear chromosome segregation
I6L39_02175	COG0488	(ABC) transporter
I6L39_02185	COG2252	PERMEase
I6L39_02190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L39_02195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L39_02200	COG3178	'Phosphotransferase
I6L39_02205	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L39_02215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L39_02220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L39_02225	COG2967	ApaG domain
I6L39_02230	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L39_02240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L39_02245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L39_02250	COG3314	Sporulation integral membrane protein YlbJ
I6L39_02255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L39_02260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L39_02265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L39_02270	COG0142	geranyltranstransferase activity
I6L39_02275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L39_02280	COG0330	HflC and HflK could
I6L39_02285	COG0330	HflC and HflK could
I6L39_02290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L39_02295	COG1923	regulation of RNA biosynthetic process
I6L39_02300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L39_02305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L39_02315	COG0802	atpase or kinase
I6L39_02320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L39_02320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L39_02340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L39_02345	COG2011	ABC-type metal ion transport system permease component
I6L39_02350	COG1464	Belongs to the NlpA lipoprotein family
I6L39_02360	COG0840	transmembrane signaling receptor activity
I6L39_02370	COG2205	protein histidine kinase activity
I6L39_02370	COG0784	Response regulator, receiver
I6L39_02385	COG2198	Histidine kinase
I6L39_02385	COG0784	Response regulator, receiver
I6L39_02385	COG5002	protein histidine kinase activity
I6L39_02405	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6L39_02420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L39_02425	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L39_02430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L39_02435	COG2716	regulation of RNA biosynthetic process
I6L39_02440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L39_02445	COG3013	Belongs to the UPF0304 family
I6L39_02455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L39_02460	COG0280	phosphate acetyltransferase
I6L39_02460	COG0857	belongs to the CobB CobQ family
I6L39_02465	COG0440	acetolactate synthase activity
I6L39_02470	COG0028	Belongs to the TPP enzyme family
I6L39_02480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L39_02485	COG0671	phosphoesterase, PA-phosphatase related
I6L39_02495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L39_02500	COG0473	3-isopropylmalate dehydrogenase activity
I6L39_02505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L39_02510	COG0066	3-isopropylmalate dehydratase activity
I6L39_02530	COG1178	ABC-type Fe3 transport system permease component
I6L39_02535	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L39_02540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L39_02550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L39_02580	COG0316	Belongs to the HesB IscA family
I6L39_02590	COG0038	chloride channel
I6L39_02595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L39_02610	COG0671	phosphoesterase, PA-phosphatase related
I6L39_02620	COG0583	DNA-binding transcription factor activity
I6L39_02625	COG2076	Multidrug Resistance protein
I6L39_02635	COG0346	lactoylglutathione lyase activity
I6L39_02640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L39_02645	COG1643	Atp-dependent helicase
I6L39_02655	COG1489	DNA binding
I6L39_02660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L39_02665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L39_02680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L39_02685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L39_02695	COG0842	Transport permease protein
I6L39_02700	COG1131	(ABC) transporter
I6L39_02715	COG0163	prenyltransferase activity
I6L39_02720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L39_02725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L39_02740	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L39_02755	COG1136	(ABC) transporter
I6L39_02780	COG2801	Transposase and inactivated derivatives
I6L39_02785	COG0529	Catalyzes the synthesis of activated sulfate
I6L39_02790	COG0471	metal ion transport
I6L39_02790	COG3273	potassium ion transport
I6L39_02795	COG2895	sulfate adenylyltransferase (ATP) activity
I6L39_02800	COG0175	sulfate reduction
I6L39_02805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L39_02805	COG1648	precorrin-2 dehydrogenase activity
I6L39_02810	COG0330	HflC and HflK could
I6L39_02815	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L39_02825	COG0673	inositol 2-dehydrogenase activity
I6L39_02835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L39_02840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L39_02850	COG3036	rescue of stalled ribosome
I6L39_02865	COG0138	bifunctional purine biosynthesis protein purh
I6L39_02870	COG0151	Belongs to the GarS family
I6L39_02895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L39_02900	COG0358	DNA primase activity
I6L39_02905	COG1610	YqeY-like protein
I6L39_02910	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L39_02915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L39_02925	COG4942	peptidase
I6L39_02925	COG1388	LysM domain
I6L39_02930	COG1238	metal cluster binding
I6L39_02935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L39_02940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L39_02945	COG0585	pseudouridine synthase activity
I6L39_02955	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L39_02960	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L39_02965	COG0148	phosphopyruvate hydratase activity
I6L39_02970	COG0504	CTP synthase activity
I6L39_02975	COG3956	TIGRFAM MazG family protein
I6L39_02980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L39_02985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L39_02995	COG4807	Protein conserved in bacteria
I6L39_03000	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L39_03005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L39_03010	COG1381	Involved in DNA repair and RecF pathway recombination
I6L39_03020	COG0571	ribonuclease III activity
I6L39_03025	COG0681	Belongs to the peptidase S26 family
I6L39_03030	COG0481	GTPase activity
I6L39_03050	COG1595	DNA-templated transcription, initiation
I6L39_03055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L39_03065	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L39_03105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L39_03110	COG0191	fructose-bisphosphate aldolase activity
I6L39_03115	COG0126	phosphoglycerate kinase activity
I6L39_03120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L39_03125	COG1940	carbohydrate kinase activity
I6L39_03130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L39_03135	COG2816	NAD+ diphosphatase activity
I6L39_03140	COG4991	sh3 domain protein
I6L39_03145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L39_03160	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L39_03165	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_03175	COG1505	serine-type exopeptidase activity
I6L39_03180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L39_03185	COG0765	amino acid transport
I6L39_03190	COG0765	amino acid transport
I6L39_03195	COG1126	abc transporter atp-binding protein
I6L39_03200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_03205	COG3174	membrane
I6L39_03210	COG0110	maltose O-acetyltransferase activity
I6L39_03245	COG0165	Argininosuccinate lyase
I6L39_03250	COG0137	argininosuccinate synthase activity
I6L39_03260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L39_03265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L39_03275	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L39_03285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L39_03320	COG0583	DNA-binding transcription factor activity
I6L39_03325	COG1380	Effector of murein hydrolase LrgA
I6L39_03330	COG1346	cytolysis
I6L39_03335	COG0460	homoserine dehydrogenase
I6L39_03335	COG0527	aspartate kinase activity
I6L39_03340	COG0626	cystathionine gamma-synthase activity
I6L39_03355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L39_03360	COG0814	amino acid
I6L39_03365	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L39_03370	COG0494	nUDIX hydrolase
I6L39_03375	COG1011	Hydrolase
I6L39_03380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L39_03395	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L39_03405	COG3156	type II secretion system protein K
I6L39_03410	COG4795	General secretion pathway protein
I6L39_03415	COG2165	general secretion pathway protein
I6L39_03430	COG2165	general secretion pathway protein
I6L39_03435	COG1459	type II secretion system
I6L39_03440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L39_03450	COG3031	protein transport across the cell outer membrane
I6L39_03460	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L39_03465	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L39_03480	COG0456	acetyltransferase
I6L39_03485	COG3133	Outer membrane lipoprotein
I6L39_03495	COG1392	Phosphate transport regulator
I6L39_03500	COG0306	phosphate transporter
I6L39_03505	COG0617	tRNA 3'-terminal CCA addition
I6L39_03510	COG3409	Peptidoglycan-binding domain 1 protein
I6L39_03510	COG3267	Type II secretory pathway component ExeA
I6L39_03520	COG1194	a g-specific adenine glycosylase
I6L39_03525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L39_03540	COG3240	lipase activity
I6L39_03550	COG3009	Protein conserved in bacteria
I6L39_03555	COG3008	intermembrane lipid transfer
I6L39_03555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L39_03560	COG2995	paraquat-inducible protein a
I6L39_03570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L39_03575	COG5001	Diguanylate cyclase
I6L39_03575	COG4251	negative regulation of phosphorylation
I6L39_03575	COG3706	GGDEF domain
I6L39_03575	COG2203	Gaf domain
I6L39_03580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L39_03585	COG2813	Specifically methylates the guanine in position
I6L39_03590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L39_03595	COG0297	glycogen (starch) synthase activity
I6L39_03635	COG1757	Na H antiporter
I6L39_03640	COG0583	DNA-binding transcription factor activity
I6L39_03645	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L39_03650	COG3842	ATPase activity
I6L39_03655	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L39_03660	COG1177	transmembrane transport
I6L39_03665	COG1012	belongs to the aldehyde dehydrogenase family
I6L39_03670	COG0109	protoheme IX farnesyltransferase activity
I6L39_03675	COG1612	heme a metabolic process
I6L39_03700	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6L39_03705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L39_03710	COG1565	acr, cog1565
I6L39_03710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L39_03715	COG1444	tRNA N-acetyltransferase activity
I6L39_03740	COG1803	Methylglyoxal synthase
I6L39_03755	COG0252	asparaginase activity
I6L39_03770	COG1609	Transcriptional regulator
I6L39_03775	COG1263	PTS System
I6L39_03775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L39_03780	COG0366	Alpha amylase catalytic
I6L39_03785	COG0110	maltose O-acetyltransferase activity
I6L39_03790	COG1522	sequence-specific DNA binding
I6L39_03835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L39_03840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L39_03855	COG0477	Major facilitator Superfamily
I6L39_03860	COG0523	cobalamin synthesis protein
I6L39_03870	COG1280	lysine exporter protein (LysE YggA)
I6L39_03880	COG2200	EAL domain
I6L39_03885	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L39_03895	COG0840	transmembrane signaling receptor activity
I6L39_03910	COG3706	GGDEF domain
I6L39_03915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L39_03920	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L39_03925	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L39_03930	COG2186	Transcriptional regulator
I6L39_03955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L39_03960	COG1459	type II secretion system
I6L39_03965	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6L39_03975	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L39_03980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L39_03985	COG0494	nUDIX hydrolase
I6L39_03995	COG0653	protein targeting
I6L39_04005	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L39_04010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L39_04015	COG0849	cell division
I6L39_04020	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6L39_04025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L39_04030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L39_04035	COG0772	Belongs to the SEDS family
I6L39_04040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L39_04045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L39_04050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L39_04060	COG0768	penicillin binding
I6L39_04065	COG3116	cell division
I6L39_04070	COG0275	rRNA processing
I6L39_04075	COG2001	Belongs to the MraZ family
I6L39_04085	COG0741	lytic transglycosylase activity
I6L39_04085	COG1388	LysM domain
I6L39_04095	COG1360	Flagellar Motor Protein
I6L39_04100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L39_04105	COG1191	sigma factor activity
I6L39_04130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L39_04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L39_04140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L39_04160	COG4786	Flagellar basal body rod
I6L39_04160	COG1256	bacterial-type flagellum assembly
I6L39_04170	COG1706	bacterial-type flagellum-dependent cell motility
I6L39_04175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L39_04180	COG4786	Flagellar basal body rod
I6L39_04190	COG1749	Flagellar hook protein flgE
I6L39_04205	COG1815	bacterial-type flagellum-dependent cell motility
I6L39_04215	COG2747	anti-sigma28 factor FlgM
I6L39_04240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L39_04250	COG1677	Flagellar hook-basal body complex protein FliE
I6L39_04275	COG1987	bacterial-type flagellum assembly
I6L39_04300	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L39_04305	COG3107	peptidoglycan biosynthetic process
I6L39_04310	COG0792	nuclease activity
I6L39_04315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L39_04320	COG2823	Periplasmic or secreted lipoprotein
I6L39_04330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L39_04335	COG2213	PTS system mannitol-specific
I6L39_04335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_04340	COG0246	Mannitol dehydrogenase
I6L39_04345	COG3722	fumarate hydratase activity
I6L39_04370	COG1671	Belongs to the UPF0178 family
I6L39_04375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L39_04380	COG0513	Belongs to the DEAD box helicase family
I6L39_04405	COG0523	cobalamin synthesis protein
I6L39_04410	COG2879	small protein
I6L39_04415	COG1966	Carbon starvation protein
I6L39_04420	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L39_04425	COG1169	isochorismate synthase
I6L39_04430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L39_04435	COG0596	Alpha beta hydrolase
I6L39_04440	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L39_04445	COG1441	menaquinone biosynthetic process
I6L39_04450	COG0318	PFAM AMP-dependent synthetase and ligase
I6L39_04455	COG3291	Pkd domain containing protein
I6L39_04460	COG2949	membrane
I6L39_04465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L39_04475	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L39_04505	COG2873	o-acetylhomoserine
I6L39_04515	COG1979	alcohol dehydrogenase
I6L39_04530	COG4221	oxidoreductase activity
I6L39_04560	COG1522	sequence-specific DNA binding
I6L39_04570	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L39_04580	COG1058	Belongs to the CinA family
I6L39_04580	COG1546	Belongs to the CinA family
I6L39_04585	COG1988	membrane-bound metal-dependent
I6L39_04595	COG0561	phosphatase activity
I6L39_04600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L39_04610	COG1011	Hydrolase
I6L39_04625	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L39_04630	COG0019	diaminopimelate decarboxylase activity
I6L39_04640	COG1965	Belongs to the frataxin family
I6L39_04645	COG0400	carboxylic ester hydrolase activity
I6L39_04650	COG3072	Adenylate cyclase
I6L39_04655	COG0181	hydroxymethylbilane synthase activity
I6L39_04665	COG2959	enzyme of heme biosynthesis
I6L39_04670	COG3071	HemY protein
I6L39_04680	COG1494	fructose-1,6-bisphosphatase
I6L39_04690	COG1214	PFAM Peptidase M22, glycoprotease
I6L39_04690	COG0456	acetyltransferase
I6L39_04710	COG1733	regulation of RNA biosynthetic process
I6L39_04725	COG3932	Exopolysaccharide synthesis, ExoD
I6L39_04740	COG0110	maltose O-acetyltransferase activity
I6L39_04750	COG1943	Transposase
I6L39_04755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L39_04760	COG2022	thiamine diphosphate biosynthetic process
I6L39_04770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L39_04775	COG0352	thiamine-phosphate diphosphorylase activity
I6L39_04780	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L39_04800	COG0642	Histidine kinase
I6L39_04805	COG0189	ligase activity
I6L39_04835	COG2321	neutral zinc metallopeptidase
I6L39_04845	COG0477	Major facilitator Superfamily
I6L39_04860	COG0312	modulator of DNA gyrase
I6L39_04865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L39_04870	COG3164	Protein of unknown function
I6L39_04875	COG1530	ribonuclease E activity
I6L39_04880	COG0424	maF-like protein
I6L39_04885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L39_04890	COG1792	Involved in formation and maintenance of cell shape
I6L39_04895	COG1077	Cell shape determining protein MreB Mrl
I6L39_04940	COG1459	type II secretion system
I6L39_04945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L39_04990	COG2200	EAL domain
I6L39_04990	COG2202	Pas domain
I6L39_04990	COG2199	diguanylate cyclase activity
I6L39_04995	COG2200	EAL domain
I6L39_05000	COG0387	Pfam Sodium calcium exchanger
I6L39_05005	COG2986	histidine ammonia-lyase
I6L39_05010	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L39_05015	COG0010	Belongs to the arginase family
I6L39_05020	COG1228	amidohydrolase
I6L39_05025	COG2188	Transcriptional regulator
I6L39_05030	COG0288	reversible hydration of carbon dioxide
I6L39_05040	COG2177	Part of the ABC transporter FtsEX involved in
I6L39_05045	COG2884	Cell division ATP-binding protein ftsE
I6L39_05050	COG0552	protein localization to endoplasmic reticulum
I6L39_05055	COG0742	ribosomal rna small subunit methyltransferase
I6L39_05080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L39_05090	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L39_05100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L39_05110	COG2095	MarC family integral membrane protein
I6L39_05120	COG1301	dicarboxylic acid transport
I6L39_05145	COG3714	YhhN family
I6L39_05160	COG2358	TRAP transporter, solute receptor (TAXI family
I6L39_05165	COG1770	oligopeptidase
I6L39_05180	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L39_05230	COG0203	ribosomal protein L17
I6L39_05235	COG0202	RNA polymerase activity
I6L39_05240	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L39_05245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L39_05250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L39_05255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L39_05260	COG0201	protein transport
I6L39_05265	COG0200	Binds to the 23S rRNA
I6L39_05270	COG1841	ribosomal large subunit assembly
I6L39_05275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L39_05280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L39_05285	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L39_05290	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L39_05295	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L39_05300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L39_05305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L39_05310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L39_05315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L39_05320	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L39_05325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L39_05330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L39_05335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L39_05340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L39_05345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L39_05350	COG0089	rRNA binding
I6L39_05355	COG0088	Forms part of the polypeptide exit tunnel
I6L39_05360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L39_05365	COG0051	transcription antitermination factor activity, RNA binding
I6L39_05375	COG2205	protein histidine kinase activity
I6L39_05385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L39_05390	COG2183	response to ionizing radiation
I6L39_05405	COG0596	Alpha beta hydrolase
I6L39_05410	COG1040	competence protein
I6L39_05415	COG0316	Belongs to the HesB IscA family
I6L39_05415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L39_05420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L39_05425	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L39_05430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L39_05435	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L39_05440	COG4942	peptidase
I6L39_05450	COG1609	Transcriptional regulator
I6L39_05465	COG0800	Aldolase
I6L39_05470	COG0129	dihydroxy-acid dehydratase activity
I6L39_05475	COG3265	gluconokinase activity
I6L39_05480	COG2610	gluconate transmembrane transporter activity
I6L39_05485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L39_05495	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L39_05505	COG0456	acetyltransferase
I6L39_05515	COG1490	D-aminoacyl-tRNA deacylase activity
I6L39_05520	COG1295	ribonuclease BN
I6L39_05525	COG1217	gtp-binding protein TYPA
I6L39_05530	COG0174	glutamine synthetase
I6L39_05540	COG3852	Histidine kinase
I6L39_05545	COG2204	response regulator
I6L39_05550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L39_05555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L39_05565	COG3078	GTPase activator activity
I6L39_05575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L39_05580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L39_05585	COG0408	coproporphyrinogen oxidase activity
I6L39_05590	COG0009	L-threonylcarbamoyladenylate synthase
I6L39_05595	COG0551	DNA topoisomerase type I activity
I6L39_05600	COG2922	Belongs to the Smg family
I6L39_05605	COG0758	DNA mediated transformation
I6L39_05615	COG0242	peptide deformylase activity
I6L39_05620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L39_05625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L39_05625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L39_05630	COG0569	domain protein
I6L39_05635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L39_05640	COG1322	Protein conserved in bacteria
I6L39_05650	COG2221	Nitrite and sulphite reductase 4Fe-4S
I6L39_05650	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L39_05660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L39_05670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L39_05670	COG0519	Catalyzes the synthesis of GMP from XMP
I6L39_05680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L39_05685	COG1396	sequence-specific DNA binding
I6L39_05690	COG1012	belongs to the aldehyde dehydrogenase family
I6L39_05700	COG2962	Rard protein
I6L39_05710	COG1280	lysine exporter protein (LysE YggA)
I6L39_05755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L39_05770	COG0583	DNA-binding transcription factor activity
I6L39_05775	COG1943	Transposase
I6L39_05795	COG0210	DNA helicase
I6L39_05800	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L39_05805	COG3845	ABC transporter
I6L39_05810	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L39_05815	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L39_05825	COG0583	DNA-binding transcription factor activity
I6L39_05845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L39_05850	COG0385	Bile acid
I6L39_05855	COG1609	Transcriptional regulator
I6L39_05890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L39_05895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L39_05895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L39_05900	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L39_05905	COG3074	FtsZ-dependent cytokinesis
I6L39_05915	COG1045	serine acetyltransferase
I6L39_05925	COG0745	RESPONSE REGULATOR receiver
I6L39_05930	COG2205	protein histidine kinase activity
I6L39_05935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L39_05940	COG0534	Mate efflux family protein
I6L39_05955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L39_05960	COG2937	Belongs to the GPAT DAPAT family
I6L39_05965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L39_05970	COG3161	chorismate lyase activity
I6L39_05975	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L39_06010	COG3307	-O-antigen
I6L39_06020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L39_06030	COG0156	8-amino-7-oxononanoate synthase activity
I6L39_06035	COG1063	alcohol dehydrogenase
I6L39_06055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L39_06060	COG2166	iron-sulfur cluster assembly
I6L39_06065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L39_06095	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L39_06100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L39_06105	COG1739	Uncharacterized protein family UPF0029
I6L39_06110	COG0006	proline dipeptidase activity
I6L39_06115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L39_06120	COG1024	Enoyl-CoA hydratase
I6L39_06120	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L39_06125	COG0183	Belongs to the thiolase family
I6L39_06140	COG1653	transport
I6L39_06150	COG0425	Belongs to the sulfur carrier protein TusA family
I6L39_06155	COG0251	oxidation-reduction process
I6L39_06160	COG2885	chlorophyll binding
I6L39_06185	COG2818	Glycosylase
I6L39_06190	COG0752	glycyl-tRNA synthetase alpha subunit
I6L39_06195	COG0751	glycine-tRNA ligase activity
I6L39_06205	COG0583	DNA-binding transcription factor activity
I6L39_06210	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L39_06230	COG0814	amino acid
I6L39_06240	COG0814	amino acid
I6L39_06245	COG3033	Beta-eliminating lyase
I6L39_06255	COG0348	domain, Protein
I6L39_06265	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L39_06270	COG0426	domain, Protein
I6L39_06270	COG1773	rubredoxin
I6L39_06275	COG3604	Transcriptional regulator
I6L39_06280	COG1609	Transcriptional regulator
I6L39_06320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L39_06335	COG2960	long-chain fatty acid transporting porin activity
I6L39_06345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L39_06360	COG3118	belongs to the thioredoxin family
I6L39_06365	COG0513	Belongs to the DEAD box helicase family
I6L39_06370	COG0248	Ppx GppA phosphatase
I6L39_06385	COG0742	ribosomal rna small subunit methyltransferase
I6L39_06405	COG0084	hydrolase, TatD family'
I6L39_06410	COG0805	protein transport
I6L39_06415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L39_06425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L39_06430	COG3165	ubiquinone biosynthetic process from chorismate
I6L39_06435	COG2226	methyltransferase
I6L39_06440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L39_06445	COG0402	S-adenosylhomocysteine deaminase activity
I6L39_06490	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L39_06495	COG0848	biopolymer transport protein
I6L39_06500	COG0811	peptide transport
I6L39_06505	COG0811	peptide transport
I6L39_06515	COG2771	luxR family
I6L39_06520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L39_06525	COG1349	DNA-binding transcription factor activity
I6L39_06530	COG0745	RESPONSE REGULATOR receiver
I6L39_06535	COG2205	protein histidine kinase activity
I6L39_06545	COG4452	Inner membrane protein CreD
I6L39_06550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L39_06555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L39_06560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L39_06565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L39_06570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L39_06575	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L39_06580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L39_06590	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L39_06600	COG1475	DNA binding
I6L39_06605	COG1192	Involved in chromosome partitioning
I6L39_06610	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L39_06615	COG0445	tRNA wobble uridine modification
I6L39_06620	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L39_06625	COG4774	siderophore transport
I6L39_06630	COG4615	Cyclic peptide transporter
I6L39_06635	COG1120	ATPase activity
I6L39_06640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L39_06650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L39_06655	COG0706	membrane insertase activity
I6L39_06660	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L39_06665	COG0594	ribonuclease P activity
I6L39_06670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L39_06675	COG1126	abc transporter atp-binding protein
I6L39_06690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L39_06695	COG0592	DNA-directed DNA polymerase activity
I6L39_06715	COG2378	regulation of single-species biofilm formation
I6L39_06725	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L39_06730	COG3977	Valine--pyruvate aminotransferase
I6L39_06745	COG2814	Major facilitator Superfamily
I6L39_06750	COG0745	RESPONSE REGULATOR receiver
I6L39_06755	COG2205	protein histidine kinase activity
I6L39_06775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L39_06780	COG4191	Histidine kinase
I6L39_06780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_06785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_06790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_06795	COG1309	transcriptional regulator
I6L39_06825	COG0561	phosphatase activity
I6L39_06830	COG2267	carboxylic ester hydrolase activity
I6L39_06835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L39_06840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L39_06845	COG1758	RNA polymerase activity
I6L39_06860	COG0859	PFAM glycosyl transferase family 9
I6L39_06865	COG3642	lipopolysaccharide core region biosynthetic process
I6L39_06905	COG0589	response to stress
I6L39_06910	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L39_06915	COG2199	diguanylate cyclase activity
I6L39_06920	COG1528	Iron-storage protein
I6L39_06925	COG2081	HI0933 family
I6L39_06930	COG2223	nitrite transmembrane transporter activity
I6L39_06940	COG3275	phosphorelay sensor kinase activity
I6L39_06945	COG3279	Response regulator of the LytR AlgR family
I6L39_06950	COG2223	nitrite transmembrane transporter activity
I6L39_06955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L39_06960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L39_06970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L39_07000	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L39_07000	COG1042	CoA-binding domain protein
I6L39_07000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L39_07010	COG0583	DNA-binding transcription factor activity
I6L39_07015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L39_07020	COG0166	Belongs to the GPI family
I6L39_07030	COG0668	transmembrane transport
I6L39_07035	COG1309	transcriptional regulator
I6L39_07040	COG0756	dUTP diphosphatase activity
I6L39_07045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L39_07050	COG2003	Belongs to the UPF0758 family
I6L39_07055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L39_07060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L39_07070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L39_07075	COG2990	Protein conserved in bacteria
I6L39_07080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L39_07085	COG0859	PFAM glycosyl transferase family 9
I6L39_07090	COG0463	Glycosyl transferase, family 2
I6L39_07095	COG0859	PFAM glycosyl transferase family 9
I6L39_07100	COG1519	Transferase
I6L39_07110	COG1561	YicC-like family, N-terminal region
I6L39_07115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L39_07120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L39_07135	COG2203	Gaf domain
I6L39_07135	COG3706	GGDEF domain
I6L39_07135	COG4251	negative regulation of phosphorylation
I6L39_07135	COG5001	Diguanylate cyclase
I6L39_07140	COG3084	Protein conserved in bacteria
I6L39_07150	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L39_07155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L39_07160	COG3639	organic phosphonate transmembrane transporter activity
I6L39_07165	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6L39_07170	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6L39_07175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6L39_07180	COG1335	isochorismatase
I6L39_07190	COG1683	Conserved Protein
I6L39_07195	COG0204	Acyl-transferase
I6L39_07200	COG0204	Acyl-transferase
I6L39_07205	COG0606	chelatase, subunit chli
I6L39_07215	COG3978	acetolactate synthase activity
I6L39_07225	COG0129	dihydroxy-acid dehydratase activity
I6L39_07240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L39_07245	COG0254	rRNA binding
I6L39_07250	COG0702	epimerase
I6L39_07255	COG0281	malic enzyme
I6L39_07265	COG2205	protein histidine kinase activity
I6L39_07270	COG0745	RESPONSE REGULATOR receiver
I6L39_07275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L39_07290	COG0366	Alpha amylase catalytic
I6L39_07305	COG0443	Heat shock 70 kDa protein
I6L39_07310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L39_07315	COG3045	CreA protein
I6L39_07335	COG0174	glutamine synthetase
I6L39_07355	COG3842	ATPase activity
I6L39_07360	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L39_07365	COG1177	transmembrane transport
I6L39_07370	COG2258	MOSC domain
I6L39_07390	COG2050	protein possibly involved in aromatic compounds catabolism
I6L39_07395	COG0514	ATP-dependent DNA helicase (RecQ)
I6L39_07405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L39_07415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L39_07420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L39_07430	COG2239	Acts as a magnesium transporter
I6L39_07435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L39_07435	COG1648	precorrin-2 dehydrogenase activity
I6L39_07440	COG2116	formate transmembrane transporter activity
I6L39_07450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L39_07455	COG0842	Transport permease protein
I6L39_07460	COG0842	Transport permease protein
I6L39_07465	COG1131	(ABC) transporter
I6L39_07470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_07485	COG0477	Major facilitator Superfamily
I6L39_07490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L39_07495	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L39_07505	COG0018	arginyl-trna synthetase
I6L39_07515	COG1595	DNA-templated transcription, initiation
I6L39_07520	COG3806	Anti-sigma factor
I6L39_07525	COG1968	undecaprenyl-diphosphatase activity
I6L39_07530	COG0667	Aldo Keto reductase
I6L39_07535	COG4580	involved in the transport of maltose and maltodextrins
I6L39_07540	COG3940	Belongs to the glycosyl hydrolase 43 family
I6L39_07555	COG1175	transmembrane transport
I6L39_07570	COG1609	Transcriptional regulator
I6L39_07580	COG2211	Major facilitator Superfamily
I6L39_07595	COG2211	Major facilitator Superfamily
I6L39_07610	COG2017	converts alpha-aldose to the beta-anomer
I6L39_07615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L39_07625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L39_07630	COG1609	Transcriptional regulator
I6L39_07635	COG3250	beta-galactosidase activity
I6L39_07645	COG1129	ABC transporter
I6L39_07680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L39_07685	COG1288	antiporter activity
I6L39_07690	COG1438	arginine binding
I6L39_07695	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L39_07700	COG0540	Belongs to the ATCase OTCase family
I6L39_07730	COG0840	transmembrane signaling receptor activity
I6L39_07735	COG3040	lipid binding
I6L39_07740	COG2207	Transcriptional regulator
I6L39_07745	COG1979	alcohol dehydrogenase
I6L39_07750	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L39_07755	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L39_07760	COG3681	Belongs to the UPF0597 family
I6L39_07765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L39_07770	COG0564	pseudouridine synthase activity
I6L39_07780	COG0542	response to heat
I6L39_07785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L39_07790	COG2502	aspartate--ammonia ligase
I6L39_07795	COG1522	sequence-specific DNA binding
I6L39_07805	COG0517	IMP dehydrogenase activity
I6L39_07805	COG0516	GMP reductase activity
I6L39_07810	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_07825	COG2205	protein histidine kinase activity
I6L39_07835	COG2204	response regulator
I6L39_07850	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6L39_07880	COG0243	molybdopterin cofactor binding
I6L39_07885	COG3005	denitrification pathway
I6L39_07895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L39_07900	COG0569	domain protein
I6L39_07905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L39_07930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L39_07945	COG0250	Participates in transcription elongation, termination and antitermination
I6L39_07950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L39_07955	COG0081	regulation of translation
I6L39_07960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L39_07965	COG0222	ribosome binding
I6L39_07970	COG0085	RNA polymerase activity
I6L39_07975	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L39_07980	COG2964	Protein conserved in bacteria
I6L39_07985	COG0251	oxidation-reduction process
I6L39_08000	COG2168	tRNA wobble position uridine thiolation
I6L39_08005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L39_08010	COG0049	tRNA binding
I6L39_08015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L39_08020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L39_08025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L39_08065	COG2252	PERMEase
I6L39_08070	COG2376	Dihydroxyacetone kinase
I6L39_08075	COG1461	Dihydroxyacetone kinase
I6L39_08095	COG0628	permease
I6L39_08120	COG0753	catalase activity
I6L39_08125	COG0454	-acetyltransferase
I6L39_08125	COG0456	acetyltransferase
I6L39_08145	COG3706	GGDEF domain
I6L39_08155	COG3842	ATPase activity
I6L39_08165	COG1175	transmembrane transport
I6L39_08190	COG0583	DNA-binding transcription factor activity
I6L39_08200	COG1741	Belongs to the pirin family
I6L39_08205	COG2259	Doxx family
I6L39_08210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L39_08215	COG1074	ATP-dependent DNA helicase activity
I6L39_08220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L39_08230	COG0346	lactoylglutathione lyase activity
I6L39_08240	COG0004	ammonium transporteR
I6L39_08245	COG0347	Belongs to the P(II) protein family
I6L39_08250	COG3706	GGDEF domain
I6L39_08280	COG1278	Cold shock
I6L39_08300	COG2197	response regulator
I6L39_08305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L39_08310	COG3047	cAMP biosynthetic process
I6L39_08315	COG0840	transmembrane signaling receptor activity
I6L39_08340	COG3135	benzoate transporter
I6L39_08345	COG1396	sequence-specific DNA binding
I6L39_08380	COG2926	Belongs to the UPF0265 family
I6L39_08390	COG3028	Belongs to the UPF0307 family
I6L39_08395	COG0312	modulator of DNA gyrase
I6L39_08400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L39_08405	COG5007	Belongs to the BolA IbaG family
I6L39_08415	COG2854	intermembrane phospholipid transfer
I6L39_08420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L39_08425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L39_08430	COG1127	ABC transporter
I6L39_08435	COG0517	IMP dehydrogenase activity
I6L39_08435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L39_08440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L39_08445	COG3117	lipopolysaccharide transmembrane transporter activity
I6L39_08450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L39_08455	COG1137	ATPase activity
I6L39_08460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L39_08470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_08475	COG1660	Displays ATPase and GTPase activities
I6L39_08480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_08500	COG3964	amidohydrolase
I6L39_08530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L39_08535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L39_08545	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L39_08550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L39_08555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L39_08560	COG0723	plastoquinol--plastocyanin reductase activity
I6L39_08565	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L39_08570	COG2857	Cytochrome c1
I6L39_08575	COG0625	glutathione transferase activity
I6L39_08580	COG2969	positive regulation of protein catabolic process
I6L39_08590	COG2771	luxR family
I6L39_08600	COG0737	Belongs to the 5'-nucleotidase family
I6L39_08605	COG1560	Kdo2-lipid A biosynthetic process
I6L39_08610	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L39_08610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L39_08615	COG1538	Outer membrane efflux protein
I6L39_08620	COG0494	nUDIX hydrolase
I6L39_08625	COG3151	Protein conserved in bacteria
I6L39_08635	COG3150	esterase
I6L39_08640	COG1051	belongs to the nudix hydrolase family
I6L39_08650	COG1566	PFAM secretion protein HlyD family protein
I6L39_08655	COG1289	transmembrane transporter activity
I6L39_08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L39_08745	COG0204	Acyl-transferase
I6L39_08750	COG1842	Phage shock protein A
I6L39_08765	COG2827	Endonuclease containing a URI domain
I6L39_08770	COG2962	Rard protein
I6L39_08775	COG1573	uracil-dna glycosylase
I6L39_08785	COG0583	DNA-binding transcription factor activity
I6L39_08790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L39_08795	COG1121	(ABC) transporter
I6L39_08800	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L39_08820	COG0739	heme binding
I6L39_08850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L39_08860	COG1546	Belongs to the CinA family
I6L39_08865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L39_08870	COG2137	regulation of response to DNA damage stimulus
I6L39_08875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L39_08880	COG0527	aspartate kinase activity
I6L39_08885	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L39_08920	COG1686	Belongs to the peptidase S11 family
I6L39_08925	COG0586	Pfam SNARE associated Golgi protein
I6L39_08930	COG1253	flavin adenine dinucleotide binding
I6L39_08935	COG0525	valine-tRNA ligase activity
I6L39_08940	COG2927	DNA polymerase III (CHI subunit)
I6L39_08945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L39_08950	COG0795	lipopolysaccharide-transporting ATPase activity
I6L39_08955	COG0795	lipopolysaccharide-transporting ATPase activity
I6L39_08970	COG0004	ammonium transporteR
I6L39_08975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L39_08985	COG2165	general secretion pathway protein
I6L39_08990	COG0084	hydrolase, TatD family'
I6L39_08995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L39_09005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L39_09010	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L39_09015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L39_09030	COG3064	Membrane
I6L39_09040	COG0560	Phosphoserine phosphatase
I6L39_09055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L39_09065	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6L39_09070	COG0776	regulation of translation
I6L39_09085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L39_09095	COG0784	Response regulator, receiver
I6L39_09095	COG5002	protein histidine kinase activity
I6L39_09095	COG2205	protein histidine kinase activity
I6L39_09105	COG3437	response regulator, receiver
I6L39_09120	COG0735	belongs to the Fur family
I6L39_09140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L39_09145	COG0513	Belongs to the DEAD box helicase family
I6L39_09150	COG3022	response to hydroperoxide
I6L39_09165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L39_09170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L39_09175	COG0762	integral membrane protein
I6L39_09180	COG1872	DUF167
I6L39_09200	COG3112	Uncharacterised protein family (UPF0231)
I6L39_09205	COG3835	regulator
I6L39_09210	COG2610	gluconate transmembrane transporter activity
I6L39_09215	COG1929	Belongs to the glycerate kinase type-1 family
I6L39_09230	COG0583	DNA-binding transcription factor activity
I6L39_09235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L39_09250	COG0347	Belongs to the P(II) protein family
I6L39_09255	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L39_09265	COG3842	ATPase activity
I6L39_09270	COG2837	iron assimilation
I6L39_09275	COG1438	arginine binding
I6L39_09280	COG1126	abc transporter atp-binding protein
I6L39_09285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_09290	COG4215	(ABC) transporter
I6L39_09295	COG4160	amino acid transport
I6L39_09300	COG0039	L-malate dehydrogenase activity
I6L39_09305	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L39_09310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L39_09310	COG1017	nitric oxide dioxygenase activity
I6L39_09320	COG4536	flavin adenine dinucleotide binding
I6L39_09325	COG4137	Cytochrome C assembly protein
I6L39_09330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L39_09335	COG0228	four-way junction DNA binding
I6L39_09340	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L39_09345	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L39_09350	COG0335	large ribosomal subunit rRNA binding
I6L39_09360	COG3066	DNA modification
I6L39_09365	COG1051	belongs to the nudix hydrolase family
I6L39_09375	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L39_09380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L39_09385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L39_09395	COG0583	DNA-binding transcription factor activity
I6L39_09400	COG0640	Transcriptional regulator
I6L39_09405	COG0268	Binds directly to 16S ribosomal RNA
I6L39_09410	COG0728	peptidoglycan biosynthetic process
I6L39_09415	COG0196	riboflavin kinase activity
I6L39_09420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L39_09425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L39_09430	COG1047	Peptidyl-prolyl cis-trans
I6L39_09435	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L39_09465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L39_09465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L39_09480	COG1854	S-ribosylhomocysteine lyase activity
I6L39_09485	COG3706	GGDEF domain
I6L39_09490	COG0557	exoribonuclease II activity
I6L39_09495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L39_09505	COG2153	protein acetylation
I6L39_09515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L39_09520	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L39_09525	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L39_09530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L39_09535	COG0359	binds to the 23S rRNA
I6L39_09570	COG1064	alcohol dehydrogenase
I6L39_09575	COG1238	metal cluster binding
I6L39_09580	COG0612	Peptidase, M16
I6L39_09585	COG2918	glutathione biosynthetic process
I6L39_09590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L39_09595	COG1027	Aspartate ammonia-lyase
I6L39_09600	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L39_09605	COG0534	Mate efflux family protein
I6L39_09610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L39_09615	COG0459	protein refolding
I6L39_09635	COG0564	pseudouridine synthase activity
I6L39_09640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L39_09670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L39_09680	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L39_09685	COG4208	sulfate ABC transporter
I6L39_09690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L39_09695	COG0583	DNA-binding transcription factor activity
I6L39_09705	COG3397	chitin binding
I6L39_09740	COG1328	CTP reductase activity
I6L39_09745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L39_09760	COG1448	Aminotransferase
I6L39_09765	COG2194	sulfuric ester hydrolase activity
I6L39_09775	COG1192	Involved in chromosome partitioning
I6L39_09785	COG1215	transferase activity, transferring glycosyl groups
I6L39_09790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6L39_09795	COG0457	Tetratricopeptide repeat
I6L39_09795	COG3118	belongs to the thioredoxin family
I6L39_09830	COG0513	Belongs to the DEAD box helicase family
I6L39_09850	COG0840	transmembrane signaling receptor activity
I6L39_09860	COG4166	transmembrane transport
I6L39_09875	COG1024	Enoyl-CoA hydratase
I6L39_09890	COG4221	oxidoreductase activity
I6L39_09895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L39_09900	COG0442	prolyl-tRNA aminoacylation
I6L39_09905	COG0632	four-way junction helicase activity
I6L39_09910	COG2255	four-way junction helicase activity
I6L39_09915	COG1271	oxidase subunit
I6L39_09920	COG1294	oxidase, subunit
I6L39_09925	COG4890	Cyd operon protein YbgT
I6L39_09930	COG3790	cyd operon protein YbgE
I6L39_09935	COG0824	Thioesterase
I6L39_09940	COG0811	peptide transport
I6L39_09955	COG0823	Involved in the tonB-independent uptake of proteins
I6L39_09960	COG2885	chlorophyll binding
I6L39_09965	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L39_10040	COG0840	transmembrane signaling receptor activity
I6L39_10045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L39_10050	COG0676	glucose-6-phosphate 1-epimerase activity
I6L39_10055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L39_10060	COG1640	4-alpha-glucanotransferase
I6L39_10065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L39_10090	COG2130	NADP-dependent
I6L39_10095	COG1846	Transcriptional regulator
I6L39_10125	COG0561	phosphatase activity
I6L39_10140	COG0733	neurotransmitter:sodium symporter activity
I6L39_10145	COG0733	neurotransmitter:sodium symporter activity
I6L39_10160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L39_10175	COG1794	racemase activity, acting on amino acids and derivatives
I6L39_10185	COG1022	Amp-dependent synthetase and ligase
I6L39_10195	COG0456	acetyltransferase
I6L39_10210	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L39_10215	COG5001	Diguanylate cyclase
I6L39_10215	COG3300	MHYT domain
I6L39_10240	COG1902	pentaerythritol trinitrate reductase activity
I6L39_10260	COG2957	Belongs to the agmatine deiminase family
I6L39_10265	COG0154	amidase activity
I6L39_10280	COG0513	Belongs to the DEAD box helicase family
I6L39_10290	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L39_10300	COG0577	efflux transmembrane transporter activity
I6L39_10300	COG1136	(ABC) transporter
I6L39_10305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_10310	COG0745	RESPONSE REGULATOR receiver
I6L39_10315	COG2205	protein histidine kinase activity
I6L39_10380	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L39_10395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_10425	COG0745	RESPONSE REGULATOR receiver
I6L39_10430	COG3104	oligopeptide transport
I6L39_10435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L39_10440	COG1555	photosystem II stabilization
I6L39_10450	COG2350	Protein conserved in bacteria
I6L39_10455	COG2917	probably involved in intracellular septation
I6L39_10460	COG0076	glutamate decarboxylase activity
I6L39_10465	COG1272	protein, Hemolysin III
I6L39_10470	COG2985	domain, Protein
I6L39_10470	COG0569	domain protein
I6L39_10480	COG0477	Major facilitator Superfamily
I6L39_10485	COG0583	DNA-binding transcription factor activity
I6L39_10490	COG3227	Zinc metalloprotease (Elastase)
I6L39_10495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L39_10500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L39_10510	COG2731	YhcH YjgK YiaL family protein
I6L39_10520	COG0668	transmembrane transport
I6L39_10525	COG1376	ErfK ybiS ycfS ynhG family protein
I6L39_10530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L39_10540	COG0789	Transcriptional regulator
I6L39_10570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L39_10580	COG0488	(ABC) transporter
I6L39_10585	COG0516	GMP reductase activity
I6L39_10585	COG0517	IMP dehydrogenase activity
I6L39_10590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6L39_10595	COG0784	Response regulator, receiver
I6L39_10595	COG0835	chemotaxis
I6L39_10600	COG2755	lipolytic protein G-D-S-L family
I6L39_10605	COG4181	ATPase activity
I6L39_10610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L39_10615	COG1090	epimerase
I6L39_10620	COG2200	EAL domain
I6L39_10625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L39_10630	COG2234	aminopeptidase activity
I6L39_10630	COG4935	Belongs to the peptidase S8 family
I6L39_10635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L39_10640	COG3171	Protein conserved in bacteria
I6L39_10645	COG2066	Belongs to the glutaminase family
I6L39_10650	COG2897	thiosulfate sulfurtransferase activity
I6L39_10660	COG1132	(ABC) transporter
I6L39_10685	COG0582	viral genome integration into host DNA
I6L39_10695	COG3621	Patatin-like phospholipase
I6L39_10705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L39_10740	COG4974	Belongs to the 'phage' integrase family
I6L39_10800	COG1070	Carbohydrate kinase
I6L39_10805	COG0738	Major facilitator superfamily
I6L39_10810	COG0346	lactoylglutathione lyase activity
I6L39_10830	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L39_10835	COG3300	MHYT domain
I6L39_10835	COG5001	Diguanylate cyclase
I6L39_10855	COG4628	conserved protein (DUF2132)
I6L39_10860	COG0688	phosphatidylethanolamine metabolic process
I6L39_10870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L39_10915	COG1278	Cold shock
I6L39_10925	COG0840	transmembrane signaling receptor activity
I6L39_10930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L39_10980	COG0848	biopolymer transport protein
I6L39_10985	COG0811	peptide transport
I6L39_10990	COG0811	peptide transport
I6L39_11000	COG4206	TonB-dependent receptor
I6L39_11010	COG4174	ABC transporter (Permease)
I6L39_11015	COG4239	(ABC) transporter, permease
I6L39_11020	COG0747	negative chemotaxis
I6L39_11025	COG0444	Belongs to the ABC transporter superfamily
I6L39_11030	COG4608	Belongs to the ABC transporter superfamily
I6L39_11035	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L39_11040	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L39_11045	COG1073	alpha beta
I6L39_11060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L39_11085	COG0243	molybdopterin cofactor binding
I6L39_11100	COG1116	anion transmembrane transporter activity
I6L39_11100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6L39_11105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6L39_11110	COG1116	anion transmembrane transporter activity
I6L39_11115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L39_11115	COG2146	nitrite reductase [NAD(P)H] activity
I6L39_11120	COG2146	nitrite reductase [NAD(P)H] activity
I6L39_11120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L39_11125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L39_11130	COG2313	pseudouridylate synthase activity
I6L39_11170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L39_11175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L39_11190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L39_11200	COG2986	histidine ammonia-lyase
I6L39_11225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L39_11235	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_11250	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L39_11260	COG2966	Psort location CytoplasmicMembrane, score
I6L39_11265	COG3610	response to peptide
I6L39_11275	COG0175	sulfate reduction
I6L39_11280	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L39_11285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L39_11295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L39_11310	COG5001	Diguanylate cyclase
I6L39_11315	COG0786	glutamate:sodium symporter activity
I6L39_11320	COG0252	asparaginase activity
I6L39_11325	COG3139	Protein of unknown function (DUF1315)
I6L39_11345	COG0616	signal peptide processing
I6L39_11350	COG1902	pentaerythritol trinitrate reductase activity
I6L39_11350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L39_11355	COG0778	Nitroreductase
I6L39_11360	COG0110	maltose O-acetyltransferase activity
I6L39_11365	COG2264	protein methyltransferase activity
I6L39_11375	COG0583	DNA-binding transcription factor activity
I6L39_11380	COG2190	(PTS) system
I6L39_11380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L39_11380	COG1263	PTS System
I6L39_11385	COG4145	pantothenate transmembrane transporter activity
I6L39_11395	COG0439	Biotin carboxylase
I6L39_11400	COG0511	ligase activity, forming carbon-carbon bonds
I6L39_11405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L39_11410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L39_11425	COG3381	protein complex oligomerization
I6L39_11435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L39_11440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L39_11445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L39_11445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L39_11460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L39_11465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L39_11470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L39_11475	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L39_11480	COG4172	Belongs to the ABC transporter superfamily
I6L39_11490	COG0601	transmembrane transport
I6L39_11500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L39_11505	COG0142	geranyltranstransferase activity
I6L39_11510	COG1722	exodeoxyribonuclease VII activity
I6L39_11515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L39_11520	COG1360	Flagellar Motor Protein
I6L39_11535	COG1534	Rna-binding protein
I6L39_11540	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L39_11550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L39_11555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L39_11560	COG0149	triose-phosphate isomerase activity
I6L39_11565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L39_11580	COG0779	Required for maturation of 30S ribosomal subunits
I6L39_11585	COG0195	Participates in both transcription termination and antitermination
I6L39_11590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L39_11595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L39_11600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L39_11605	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L39_11610	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L39_11615	COG2211	Major facilitator Superfamily
I6L39_11620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L39_11630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L39_11635	COG0826	peptidase U32
I6L39_11650	COG0312	modulator of DNA gyrase
I6L39_11655	COG0312	modulator of DNA gyrase
I6L39_11675	COG4974	Belongs to the 'phage' integrase family
I6L39_11685	COG1970	mechanosensitive ion channel activity
I6L39_11700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L39_11705	COG0789	Transcriptional regulator
I6L39_11720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L39_11730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L39_11735	COG0321	lipoyl(octanoyl) transferase activity
I6L39_11740	COG2921	Belongs to the UPF0250 family
I6L39_11745	COG1686	Belongs to the peptidase S11 family
I6L39_11750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L39_11755	COG2951	lytic endotransglycosylase activity
I6L39_11760	COG0772	Belongs to the SEDS family
I6L39_11765	COG0768	penicillin binding
I6L39_11770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L39_11775	COG0799	negative regulation of ribosome biogenesis
I6L39_11780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L39_11795	COG0495	leucyl-tRNA aminoacylation
I6L39_11800	COG2888	peptidyl-tyrosine sulfation
I6L39_11805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L39_11810	COG4535	Mg2 and Co2 transporter CorC
I6L39_11815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L39_11820	COG1702	phosphate starvation-inducible protein PhoH
I6L39_11830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L39_11845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L39_11855	COG3706	GGDEF domain
I6L39_11865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L39_11875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L39_11885	COG0516	GMP reductase activity
I6L39_11895	COG0642	Histidine kinase
I6L39_11910	COG0300	oxidoreductase activity
I6L39_11935	COG3214	Protein conserved in bacteria
I6L39_11940	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L39_11945	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L39_11950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L39_11955	COG1053	succinate dehydrogenase
I6L39_11965	COG0584	glycerophosphoryl diester phosphodiesterase
I6L39_11970	COG3264	Mechanosensitive ion channel
I6L39_11970	COG1511	domain protein
I6L39_11980	COG0739	heme binding
I6L39_11990	COG3121	Chaperone
I6L39_11995	COG3188	usher protein
I6L39_12000	COG3121	Chaperone
I6L39_12015	COG0583	DNA-binding transcription factor activity
I6L39_12030	COG0583	DNA-binding transcription factor activity
I6L39_12035	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L39_12065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L39_12070	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L39_12080	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L39_12085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L39_12095	COG0180	Tryptophanyl-tRNA synthetase
I6L39_12110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L39_12120	COG1012	belongs to the aldehyde dehydrogenase family
I6L39_12130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L39_12140	COG0657	acetylesterase activity
I6L39_12145	COG3097	Belongs to the UPF0267 family
I6L39_12165	COG0471	metal ion transport
I6L39_12165	COG0490	domain, Protein
I6L39_12210	COG0012	GTP binding
I6L39_12215	COG0193	aminoacyl-tRNA hydrolase activity
I6L39_12220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L39_12230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L39_12235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L39_12240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L39_12245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L39_12250	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L39_12260	COG2912	Transglutaminase-like superfamily
I6L39_12265	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L39_12270	COG1301	dicarboxylic acid transport
I6L39_12280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L39_12295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L39_12300	COG1115	amino acid carrier protein
I6L39_12315	COG0714	Associated with various cellular activities
I6L39_12325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L39_12340	COG0189	ligase activity
I6L39_12345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L39_12355	COG3091	SprT-like family
I6L39_12365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L39_12375	COG0251	oxidation-reduction process
I6L39_12385	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L39_12390	COG0739	heme binding
I6L39_12395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L39_12405	COG1881	PFAM PEBP family protein
I6L39_12410	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L39_12415	COG0583	DNA-binding transcription factor activity
I6L39_12425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L39_12435	COG0583	DNA-binding transcription factor activity
I6L39_12440	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_12445	COG0616	signal peptide processing
I6L39_12450	COG3724	N-succinylarginine dihydrolase activity
I6L39_12470	COG0840	transmembrane signaling receptor activity
I6L39_12480	COG2971	BadF BadG BcrA BcrD
I6L39_12490	COG4608	Belongs to the ABC transporter superfamily
I6L39_12495	COG0444	Belongs to the ABC transporter superfamily
I6L39_12500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L39_12515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L39_12525	COG1677	Flagellar hook-basal body complex protein FliE
I6L39_12535	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L39_12590	COG1684	flagellar biosynthetic protein fliR
I6L39_12600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L39_12625	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L39_12630	COG0643	Histidine kinase
I6L39_12630	COG0784	Response regulator, receiver
I6L39_12630	COG2198	Histidine kinase
I6L39_12635	COG2201	protein-glutamate methylesterase activity
I6L39_12640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L39_12645	COG1360	Flagellar Motor Protein
I6L39_12650	COG1192	Involved in chromosome partitioning
I6L39_12660	COG0835	chemotaxis
I6L39_12675	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L39_12680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L39_12685	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L39_12690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L39_12695	COG1138	Cytochrome C-type biogenesis protein
I6L39_12700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L39_12710	COG0457	Tetratricopeptide repeat
I6L39_12725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L39_12730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L39_12730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L39_12745	COG0259	pyridoxamine-phosphate oxidase activity
I6L39_12755	COG3153	acetyltransferase
I6L39_12775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L39_12780	COG2867	negative regulation of translational initiation
I6L39_12785	COG2914	Belongs to the UPF0125 (RnfH) family
I6L39_12790	COG0702	epimerase
I6L39_12795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L39_12815	COG0564	pseudouridine synthase activity
I6L39_12820	COG1957	nucleoside hydrolase
I6L39_12845	COG1280	lysine exporter protein (LysE YggA)
I6L39_12855	COG3263	regulation of cellular component size
I6L39_12865	COG1876	peptidase activity
I6L39_12870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L39_12875	COG1393	Belongs to the ArsC family
I6L39_12890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L39_12895	COG0017	Asparaginyl-tRNA synthetase
I6L39_12910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L39_12915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L39_12920	COG0156	8-amino-7-oxononanoate synthase activity
I6L39_12930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L39_12935	COG0501	Belongs to the peptidase M48B family
I6L39_12940	COG0633	Ferredoxin
I6L39_12940	COG3217	Mosc domain protein beta barrel domain protein
I6L39_12940	COG0633	Ferredoxin
I6L39_12940	COG3217	Mosc domain protein beta barrel domain protein
I6L39_12950	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L39_12950	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L39_12950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L39_12950	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L39_12960	COG2801	Transposase and inactivated derivatives
I6L39_12965	COG2841	Protein conserved in bacteria
I6L39_12975	COG0534	Mate efflux family protein
I6L39_13010	COG1309	transcriptional regulator
I6L39_13025	COG0791	NLP P60 protein
I6L39_13030	COG0583	DNA-binding transcription factor activity
I6L39_13050	COG0500	methyltransferase
I6L39_13055	COG4106	trans-aconitate 2-methyltransferase activity
I6L39_13060	COG1801	Protein of unknown function DUF72
I6L39_13065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L39_13070	COG0217	transcriptional regulatory protein
I6L39_13075	COG2194	sulfuric ester hydrolase activity
I6L39_13080	COG1846	Transcriptional regulator
I6L39_13080	COG1940	carbohydrate kinase activity
I6L39_13085	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L39_13090	COG0363	glucosamine-6-phosphate deaminase activity
I6L39_13095	COG2190	(PTS) system
I6L39_13095	COG1263	PTS System
I6L39_13095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L39_13105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L39_13110	COG0735	belongs to the Fur family
I6L39_13120	COG0716	FMN binding
I6L39_13135	COG0596	Alpha beta hydrolase
I6L39_13140	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L39_13145	COG0033	Phosphoglucomutase
I6L39_13155	COG1846	Transcriptional regulator
I6L39_13160	COG2951	lytic endotransglycosylase activity
I6L39_13165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L39_13170	COG4136	ATPase activity
I6L39_13180	COG4134	Bacterial extracellular solute-binding protein
I6L39_13185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L39_13190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L39_13200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L39_13210	COG0729	surface antigen
I6L39_13215	COG2911	Protein conserved in bacteria
I6L39_13235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L39_13245	COG0741	lytic transglycosylase activity
I6L39_13260	COG1607	acyl-coa hydrolase
I6L39_13270	COG3021	interspecies interaction between organisms
I6L39_13275	COG0741	lytic transglycosylase activity
I6L39_13275	COG1388	LysM domain
I6L39_13280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L39_13285	COG2226	methyltransferase
I6L39_13290	COG0328	RNA-DNA hybrid ribonuclease activity
I6L39_13295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L39_13305	COG0784	Response regulator, receiver
I6L39_13305	COG3437	response regulator, receiver
I6L39_13310	COG1960	acyl-CoA dehydrogenase activity
I6L39_13315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L39_13320	COG0121	glutamine amidotransferase
I6L39_13355	COG2197	response regulator
I6L39_13360	COG3850	Histidine kinase
I6L39_13365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L39_13370	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L39_13370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L39_13380	COG0243	molybdopterin cofactor binding
I6L39_13385	COG0437	4 iron, 4 sulfur cluster binding
I6L39_13390	COG0348	domain, Protein
I6L39_13400	COG3005	denitrification pathway
I6L39_13405	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L39_13410	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L39_13415	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L39_13420	COG0314	molybdopterin synthase activity
I6L39_13435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L39_13440	COG2267	carboxylic ester hydrolase activity
I6L39_13455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L39_13465	COG0302	gtp cyclohydrolase
I6L39_13470	COG0840	transmembrane signaling receptor activity
I6L39_13475	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L39_13485	COG0583	DNA-binding transcription factor activity
I6L39_13500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L39_13515	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L39_13520	COG1166	arginine decarboxylase activity
I6L39_13555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L39_13560	COG1187	pseudouridine synthase activity
I6L39_13565	COG2807	transmembrane transport
I6L39_13575	COG0583	DNA-binding transcription factor activity
I6L39_13605	COG2979	Protein of unknown function (DUF533)
I6L39_13620	COG1595	DNA-templated transcription, initiation
I6L39_13635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L39_13645	COG1294	oxidase, subunit
I6L39_13655	COG2814	Major facilitator Superfamily
I6L39_13660	COG0656	L-ascorbic acid biosynthetic process
I6L39_13680	COG0583	DNA-binding transcription factor activity
I6L39_13685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L39_13690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L39_13695	COG2271	Major facilitator Superfamily
I6L39_13700	COG1349	DNA-binding transcription factor activity
I6L39_13710	COG0584	glycerophosphoryl diester phosphodiesterase
I6L39_13715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L39_13720	COG1605	Chorismate mutase
I6L39_13720	COG0287	Prephenate dehydrogenase
I6L39_13730	COG3085	chromosome segregation
I6L39_13735	COG4574	serine-type endopeptidase inhibitor activity
I6L39_13745	COG3083	sulfuric ester hydrolase activity
I6L39_13750	COG3082	Protein of unknown function (DUF1414)
I6L39_13755	COG3081	Nucleoid-associated protein
I6L39_13760	COG2182	Extracellular solute-binding protein
I6L39_13765	COG1175	transmembrane transport
I6L39_13770	COG3833	ABC-type maltose transport systems, permease component
I6L39_13775	COG3842	ATPase activity
I6L39_13800	COG0425	Belongs to the sulfur carrier protein TusA family
I6L39_13805	COG4783	chaperone-mediated protein folding
I6L39_13815	COG1393	Belongs to the ArsC family
I6L39_13825	COG1228	amidohydrolase
I6L39_13835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_13840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L39_13845	COG2431	L-lysine efflux transmembrane transporter activity
I6L39_13855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_13860	COG4215	(ABC) transporter
I6L39_13885	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L39_13895	COG1216	Glycosyl transferase, family 2
I6L39_13895	COG1442	glycosyl transferase family 8
I6L39_13900	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6L39_13905	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L39_13950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L39_13960	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L39_13990	COG2373	Large extracellular alpha-helical protein
I6L39_13995	COG4953	penicillin-binding protein 1C
I6L39_14005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L39_14005	COG0301	tRNA thio-modification
I6L39_14025	COG1334	flagellar protein FlaG
I6L39_14055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L39_14065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L39_14080	COG0346	lactoylglutathione lyase activity
I6L39_14085	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L39_14090	COG4660	Part of a membrane complex involved in electron transport
I6L39_14095	COG4659	FMN binding
I6L39_14100	COG4658	electron transport chain
I6L39_14105	COG4656	Part of a membrane complex involved in electron transport
I6L39_14110	COG2878	Part of a membrane complex involved in electron transport
I6L39_14115	COG4657	Part of a membrane complex involved in electron transport
I6L39_14120	COG0697	spore germination
I6L39_14140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L39_14145	COG1288	antiporter activity
I6L39_14150	COG0436	Aminotransferase
I6L39_14160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L39_14165	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L39_14170	COG1061	Type III restriction enzyme res subunit
I6L39_14175	COG1566	PFAM secretion protein HlyD family protein
I6L39_14185	COG3264	Mechanosensitive ion channel
I6L39_14185	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L39_14190	COG1966	Carbon starvation protein
I6L39_14195	COG3279	Response regulator of the LytR AlgR family
I6L39_14200	COG3275	phosphorelay sensor kinase activity
I6L39_14210	COG1012	belongs to the aldehyde dehydrogenase family
I6L39_14210	COG1454	alcohol dehydrogenase
I6L39_14220	COG2095	MarC family integral membrane protein
I6L39_14230	COG0601	transmembrane transport
I6L39_14235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L39_14250	COG0861	Integral membrane protein TerC family
I6L39_14255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L39_14265	COG1301	dicarboxylic acid transport
I6L39_14280	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L39_14295	COG0537	adenosine 5'-monophosphoramidase activity
I6L39_14330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L39_14335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L39_14345	COG2354	Protein conserved in bacteria
I6L39_14360	COG3150	esterase
I6L39_14365	COG1252	NADH dehydrogenase
I6L39_14370	COG0393	Putative heavy-metal-binding
I6L39_14375	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L39_14380	COG1368	sulfuric ester hydrolase activity
I6L39_14390	COG0527	aspartate kinase activity
I6L39_14395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L39_14395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L39_14400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L39_14425	COG0583	DNA-binding transcription factor activity
I6L39_14430	COG1620	l-lactate permease
I6L39_14435	COG0247	lactate metabolic process
I6L39_14440	COG1139	Iron-sulfur cluster binding protein
I6L39_14465	COG0577	efflux transmembrane transporter activity
I6L39_14470	COG1136	(ABC) transporter
I6L39_14490	COG2814	Major facilitator Superfamily
I6L39_14515	COG0672	)-iron permease
I6L39_14550	COG2308	Evidence 4 Homologs of previously reported genes of
I6L39_14565	COG0659	secondary active sulfate transmembrane transporter activity
I6L39_14580	COG3039	Transposase
I6L39_14600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L39_14605	COG0437	4 iron, 4 sulfur cluster binding
I6L39_14610	COG5557	Pfam Polysulphide reductase, NrfD
I6L39_14615	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L39_14620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L39_14625	COG1773	rubredoxin
I6L39_14640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L39_14650	COG3842	ATPase activity
I6L39_14660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L39_14665	COG0375	protein maturation
I6L39_14670	COG0309	Hydrogenase expression formation protein (HypE)
I6L39_14680	COG0298	carbon dioxide binding
I6L39_14685	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L39_14690	COG3158	transport of potassium into the cell
I6L39_14700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L39_14705	COG0326	Molecular chaperone. Has ATPase activity
I6L39_14710	COG0563	adenylate kinase activity
I6L39_14715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L39_14720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L39_14725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L39_14730	COG0840	transmembrane signaling receptor activity
I6L39_14745	COG3300	MHYT domain
I6L39_14745	COG5001	Diguanylate cyclase
I6L39_14750	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L39_14770	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L39_14775	COG1535	isochorismatase
I6L39_14775	COG3433	isochorismatase activity
I6L39_14780	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L39_14785	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_14795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L39_14810	COG1120	ATPase activity
I6L39_14815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L39_14820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L39_14825	COG4771	TonB-dependent receptor
I6L39_14865	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L39_14870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L39_14875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L39_14880	COG0861	Integral membrane protein TerC family
I6L39_14895	COG1022	Amp-dependent synthetase and ligase
I6L39_14900	COG0295	cytidine deaminase activity
I6L39_14905	COG1346	cytolysis
I6L39_14910	COG1380	Effector of murein hydrolase LrgA
I6L39_14915	COG3345	alpha-galactosidase
I6L39_14925	COG2925	Exonuclease
I6L39_15020	COG2217	Heavy metal translocating P-type atpase
I6L39_15030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_15055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L39_15065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L39_15070	COG0436	Aminotransferase
I6L39_15080	COG2160	L-arabinose isomerase activity
I6L39_15090	COG1069	ribulokinase activity
I6L39_15095	COG1879	ABC-type sugar transport system periplasmic component
I6L39_15100	COG1129	ABC transporter
I6L39_15105	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L39_15115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L39_15120	COG0254	rRNA binding
I6L39_15135	COG1451	nucleotide metabolic process
I6L39_15150	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L39_15160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L39_15160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L39_15165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L39_15185	COG2009	succinate dehydrogenase
I6L39_15190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L39_15195	COG1053	succinate dehydrogenase
I6L39_15205	COG0567	Dehydrogenase, E1 component
I6L39_15210	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L39_15215	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L39_15220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6L39_15230	COG2983	Belongs to the UPF0260 family
I6L39_15235	COG1882	Formate acetyltransferase
I6L39_15240	COG2116	formate transmembrane transporter activity
I6L39_15245	COG1944	ATP diphosphatase activity
I6L39_15255	COG2076	Multidrug Resistance protein
I6L39_15260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L39_15265	COG1278	Cold shock
I6L39_15270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L39_15275	COG0542	response to heat
I6L39_15280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L39_15285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L39_15290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L39_15295	COG3134	Outer membrane lipoprotein
I6L39_15300	COG3706	GGDEF domain
I6L39_15305	COG0492	ferredoxin-NADP+ reductase activity
I6L39_15310	COG0686	Belongs to the AlaDH PNT family
I6L39_15320	COG1674	ftsk spoiiie
I6L39_15320	COG0531	amino acid
I6L39_15325	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L39_15330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L39_15335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L39_15340	COG1286	toxin biosynthetic process
I6L39_15345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L39_15350	COG2723	6-phospho-beta-galactosidase activity
I6L39_15355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L39_15355	COG1263	PTS System
I6L39_15360	COG1609	Transcriptional regulator
I6L39_15370	COG4172	Belongs to the ABC transporter superfamily
I6L39_15380	COG4171	peptide transport system, permease
I6L39_15385	COG4168	peptide transport system, permease
I6L39_15395	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L39_15400	COG1842	Phage shock protein A
I6L39_15415	COG3106	COG3106 Predicted ATPase
I6L39_15420	COG3768	UPF0283 membrane protein
I6L39_15430	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L39_15450	COG2885	chlorophyll binding
I6L39_15460	COG1570	exodeoxyribonuclease VII activity
I6L39_15485	COG1874	Beta-galactosidase
I6L39_15485	COG0366	Alpha amylase catalytic
I6L39_15495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6L39_15500	COG0516	GMP reductase activity
I6L39_15500	COG0517	IMP dehydrogenase activity
I6L39_15505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L39_15505	COG0519	Catalyzes the synthesis of GMP from XMP
I6L39_15550	COG2062	phosphohistidine phosphatase, SixA
I6L39_15560	COG0697	spore germination
I6L39_15565	COG4166	transmembrane transport
I6L39_15570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L39_15575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L39_15585	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L39_15590	COG1136	(ABC) transporter
I6L39_15595	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L39_15600	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L39_15610	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L39_15615	COG0740	serine-type endopeptidase activity
I6L39_15620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L39_15625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L39_15630	COG0776	regulation of translation
I6L39_15635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L39_15640	COG0488	(ABC) transporter
I6L39_15645	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L39_15650	COG3162	membrane
I6L39_15665	COG1024	Enoyl-CoA hydratase
I6L39_15670	COG1115	amino acid carrier protein
I6L39_15680	COG3228	Belongs to the MtfA family
I6L39_15685	COG1584	GPR1 FUN34 yaaH family protein
I6L39_15710	COG1024	Enoyl-CoA hydratase
I6L39_15715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L39_15720	COG1960	acyl-CoA dehydrogenase activity
I6L39_15730	COG1960	acyl-CoA dehydrogenase activity
I6L39_15735	COG1024	Enoyl-CoA hydratase
I6L39_15740	COG1024	Enoyl-CoA hydratase
I6L39_15750	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_15760	COG0730	response to heat
I6L39_15775	COG0653	protein targeting
I6L39_15800	COG1464	Belongs to the NlpA lipoprotein family
I6L39_15810	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L39_15815	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L39_15820	COG1129	ABC transporter
I6L39_15825	COG1879	ABC-type sugar transport system periplasmic component
I6L39_15830	COG0583	DNA-binding transcription factor activity
I6L39_15845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L39_15850	COG0243	molybdopterin cofactor binding
I6L39_15870	COG2723	6-phospho-beta-galactosidase activity
I6L39_15880	COG0583	DNA-binding transcription factor activity
I6L39_15895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L39_15900	COG0673	inositol 2-dehydrogenase activity
I6L39_15905	COG0583	DNA-binding transcription factor activity
I6L39_15920	COG1560	Kdo2-lipid A biosynthetic process
I6L39_15940	COG0417	DNA replication proofreading
I6L39_15970	COG0534	Mate efflux family protein
I6L39_15980	COG0307	riboflavin synthase, alpha
I6L39_15990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L39_15995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L39_16000	COG0697	spore germination
I6L39_16005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L39_16045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L39_16050	COG3099	Belongs to the UPF0263 family
I6L39_16055	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L39_16060	COG2894	cell division
I6L39_16065	COG0850	regulation of cytokinetic process
I6L39_16070	COG3100	YcgL domain-containing protein
I6L39_16075	COG2951	lytic endotransglycosylase activity
I6L39_16080	COG1760	l-serine dehydratase
I6L39_16085	COG1760	l-serine dehydratase
I6L39_16090	COG3123	guanosine phosphorylase activity
I6L39_16110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L39_16115	COG2067	long-chain fatty acid transport protein
I6L39_16120	COG2067	long-chain fatty acid transport protein
I6L39_16130	COG1595	DNA-templated transcription, initiation
I6L39_16140	COG2304	oxidoreductase activity
I6L39_16160	COG0714	Associated with various cellular activities
I6L39_16165	COG0183	Belongs to the thiolase family
I6L39_16170	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L39_16170	COG1024	Enoyl-CoA hydratase
I6L39_16180	COG4681	YaeQ
I6L39_16200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L39_16220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_16230	COG1538	Outer membrane efflux protein
I6L39_16250	COG3134	Outer membrane lipoprotein
I6L39_16255	COG0318	PFAM AMP-dependent synthetase and ligase
I6L39_16265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L39_16265	COG0140	phosphoribosyl-ATP diphosphatase activity
I6L39_16270	COG0107	imidazoleglycerol-phosphate synthase activity
I6L39_16275	COG0784	Response regulator, receiver
I6L39_16275	COG2205	protein histidine kinase activity
I6L39_16275	COG2198	Histidine kinase
I6L39_16280	COG2199	diguanylate cyclase activity
I6L39_16285	COG3437	response regulator, receiver
I6L39_16290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L39_16295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L39_16300	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L39_16300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L39_16305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L39_16310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L39_16315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L39_16325	COG1199	ATP-dependent helicase activity
I6L39_16330	COG1214	PFAM Peptidase M22, glycoprotease
I6L39_16340	COG0596	Alpha beta hydrolase
I6L39_16345	COG0318	PFAM AMP-dependent synthetase and ligase
I6L39_16365	COG2197	response regulator
I6L39_16375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L39_16380	COG2832	Protein of unknown function (DUF454)
I6L39_16385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L39_16395	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L39_16400	COG1335	isochorismatase
I6L39_16415	COG2197	response regulator
I6L39_16420	COG0517	IMP dehydrogenase activity
I6L39_16420	COG0617	tRNA 3'-terminal CCA addition
I6L39_16420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L39_16425	COG1643	Atp-dependent helicase
I6L39_16435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L39_16450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L39_16455	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L39_16460	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L39_16470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L39_16480	COG1254	Belongs to the acylphosphatase family
I6L39_16490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L39_16490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L39_16495	COG0489	protein tyrosine kinase activity
I6L39_16500	COG0572	uridine kinase
I6L39_16505	COG0717	Belongs to the dCTP deaminase family
I6L39_16510	COG0306	phosphate transporter
I6L39_16515	COG1530	ribonuclease E activity
I6L39_16525	COG0424	maF-like protein
I6L39_16535	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L39_16540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L39_16545	COG0416	fatty acid biosynthetic process
I6L39_16550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L39_16560	COG1028	Short-chain dehydrogenase reductase Sdr
I6L39_16565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L39_16575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L39_16580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L39_16585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L39_16590	COG0470	DNA polymerase III
I6L39_16595	COG0084	hydrolase, TatD family'
I6L39_16610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L39_16610	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L39_16615	COG3008	intermembrane lipid transfer
I6L39_16620	COG2995	paraquat-inducible protein a
I6L39_16630	COG3141	response to X-ray
I6L39_16640	COG1067	ATP-dependent peptidase activity
I6L39_16645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L39_16660	COG0488	(ABC) transporter
I6L39_16670	COG0116	Belongs to the methyltransferase superfamily
I6L39_16670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L39_16680	COG0167	dihydroorotate dehydrogenase activity
I6L39_16685	COG2902	Dehydrogenase
I6L39_16695	COG0308	aminopeptidase N
I6L39_16705	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L39_16710	COG1956	GAF domain-containing protein
I6L39_16720	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L39_16735	COG2010	Cytochrome c
I6L39_16760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L39_16765	COG0589	response to stress
I6L39_16770	COG0037	tRNA processing
I6L39_16785	COG0625	glutathione transferase activity
I6L39_16790	COG1869	D-ribose catabolic process
I6L39_16795	COG1129	ABC transporter
I6L39_16800	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L39_16805	COG1879	ABC-type sugar transport system periplasmic component
I6L39_16810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L39_16815	COG1609	Transcriptional regulator
I6L39_16820	COG3300	MHYT domain
I6L39_16820	COG5001	Diguanylate cyclase
I6L39_16845	COG0784	Response regulator, receiver
I6L39_16845	COG2205	protein histidine kinase activity
I6L39_16850	COG0776	regulation of translation
I6L39_16855	COG0072	phenylalanine-tRNA ligase activity
I6L39_16855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L39_16860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L39_16865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L39_16870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L39_16875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L39_16880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L39_16905	COG0366	Alpha amylase catalytic
I6L39_16915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L39_16925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L39_16930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L39_16935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L39_16940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L39_16945	COG3313	Fe-S protein
I6L39_16950	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L39_16950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L39_16950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L39_16955	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L39_16960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_16960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L39_16965	COG1609	Transcriptional regulator
I6L39_16970	COG0814	amino acid
I6L39_16980	COG5654	RES domain protein
I6L39_16985	COG0513	Belongs to the DEAD box helicase family
I6L39_16995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L39_17000	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L39_17005	COG2840	Smr protein MutS2
I6L39_17015	COG0406	alpha-ribazole phosphatase activity
I6L39_17045	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L39_17050	COG0384	phenazine biosynthesis protein PhzF
I6L39_17075	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L39_17080	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L39_17085	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L39_17095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L39_17100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L39_17110	COG0205	6-phosphofructokinase activity
I6L39_17115	COG1473	amidohydrolase
I6L39_17120	COG1011	Hydrolase
I6L39_17125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L39_17170	COG3593	DNA synthesis involved in DNA repair
I6L39_17185	COG0583	DNA-binding transcription factor activity
I6L39_17190	COG0730	response to heat
I6L39_17195	COG3148	PFAM DTW domain containing protein
I6L39_17200	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L39_17210	COG0386	Belongs to the glutathione peroxidase family
I6L39_17215	COG0513	Belongs to the DEAD box helicase family
I6L39_17245	COG2329	Antibiotic biosynthesis monooxygenase
I6L39_17250	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L39_17280	COG2501	S4 domain
I6L39_17300	COG1132	(ABC) transporter
I6L39_17305	COG1132	(ABC) transporter
I6L39_17315	COG3118	belongs to the thioredoxin family
I6L39_17320	COG0471	metal ion transport
I6L39_17330	COG0058	SHG alpha-glucan phosphorylase activity
I6L39_17360	COG0814	amino acid
I6L39_17365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L39_17370	COG0514	ATP-dependent DNA helicase (RecQ)
I6L39_17375	COG2766	serine protein kinase
I6L39_17380	COG2718	Belongs to the UPF0229 family
I6L39_17385	COG2719	SpoVR family
I6L39_17390	COG2186	Transcriptional regulator
I6L39_17395	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L39_17400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L39_17405	COG0586	Pfam SNARE associated Golgi protein
I6L39_17415	COG0556	nucleotide-excision repair
I6L39_17425	COG2985	domain, Protein
I6L39_17425	COG0569	domain protein
I6L39_17430	COG0739	heme binding
I6L39_17430	COG1196	nuclear chromosome segregation
I6L39_17430	COG0741	lytic transglycosylase activity
I6L39_17435	COG1940	carbohydrate kinase activity
I6L39_17435	COG1846	Transcriptional regulator
I6L39_17445	COG3012	SEC-C Motif Domain Protein
I6L39_17450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L39_17455	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L39_17465	COG0247	lactate metabolic process
I6L39_17485	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L39_17490	COG0437	4 iron, 4 sulfur cluster binding
I6L39_17495	COG3301	Polysulphide reductase, NrfD
I6L39_17500	COG1138	Cytochrome C-type biogenesis protein
I6L39_17510	COG4235	cytochrome complex assembly
I6L39_17510	COG3088	subunit of a heme lyase
I6L39_17525	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L39_17530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L39_17545	COG0517	IMP dehydrogenase activity
I6L39_17550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L39_17555	COG0583	DNA-binding transcription factor activity
I6L39_17565	COG4774	siderophore transport
I6L39_17570	COG1917	Cupin 2, conserved barrel domain protein
I6L39_17570	COG4977	sequence-specific DNA binding
I6L39_17580	COG0583	DNA-binding transcription factor activity
I6L39_17585	COG2910	NAD(P)H-binding
I6L39_17595	COG0626	cystathionine gamma-synthase activity
I6L39_17600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L39_17955	COG3550	peptidyl-serine autophosphorylation
I6L39_17965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6L39_17995	COG1435	thymidine kinase activity
I6L39_18000	COG1757	Na H antiporter
I6L39_18005	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L39_18010	COG2096	Adenosyltransferase
I6L39_18015	COG3530	Putative quorum-sensing-regulated virulence factor
I6L39_18020	COG0602	queuosine metabolic process
I6L39_18025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L39_18045	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L39_18055	COG0776	regulation of translation
I6L39_18060	COG0539	negative regulation of cytoplasmic translation
I6L39_18065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L39_18070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L39_18075	COG0583	DNA-binding transcription factor activity
I6L39_18080	COG2814	Major facilitator Superfamily
I6L39_18100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L39_18105	COG5001	Diguanylate cyclase
I6L39_18105	COG3300	MHYT domain
I6L39_18115	COG0583	DNA-binding transcription factor activity
I6L39_18120	COG0745	RESPONSE REGULATOR receiver
I6L39_18145	COG4989	oxidoreductase activity
I6L39_18150	COG0724	RNA recognition motif
I6L39_18160	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6L39_18170	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L39_18190	COG2801	Transposase and inactivated derivatives
I6L39_18195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L39_18200	COG1360	Flagellar Motor Protein
I6L39_18205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L39_18210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L39_18215	COG0649	NAD binding
I6L39_18215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L39_18230	COG1034	ATP synthesis coupled electron transport
I6L39_18235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L39_18240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L39_18245	COG0839	Belongs to the complex I subunit 6 family
I6L39_18250	COG0713	ATP synthesis coupled electron transport
I6L39_18260	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L39_18265	COG1007	ATP synthesis coupled electron transport
I6L39_18270	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L39_18270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L39_18275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L39_18280	COG1645	bacterial-type flagellum-dependent swarming motility
I6L39_18285	COG1160	GTP binding
I6L39_18290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L39_18295	COG2976	Protein conserved in bacteria
I6L39_18300	COG0124	histidyl-tRNA synthetase
I6L39_18320	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L39_18325	COG0105	UTP biosynthetic process
I6L39_18330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L39_18340	COG0633	Ferredoxin
I6L39_18345	COG0443	Heat shock 70 kDa protein
I6L39_18350	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L39_18360	COG0822	iron-sulfur transferase activity
I6L39_18365	COG1104	cysteine desulfurase activity
I6L39_18385	COG3154	lipid carrier protein
I6L39_18390	COG0826	peptidase U32
I6L39_18395	COG0826	peptidase U32
I6L39_18410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L39_18420	COG1862	Preprotein translocase
I6L39_18425	COG0343	queuine tRNA-ribosyltransferase activity
I6L39_18430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L39_18435	COG0517	IMP dehydrogenase activity
I6L39_18445	COG3634	alkyl hydroperoxide reductase activity
I6L39_18480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L39_18480	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L39_18485	COG0509	glycine decarboxylation via glycine cleavage system
I6L39_18490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L39_18495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L39_18500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L39_18505	COG3079	Belongs to the UPF0149 family
I6L39_18520	COG2814	Major facilitator Superfamily
I6L39_18525	COG0625	glutathione transferase activity
I6L39_18540	COG0483	inositol monophosphate 1-phosphatase activity
I6L39_18555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L39_18560	COG2056	Na+-H+ antiporter family
I6L39_18565	COG2814	Major facilitator Superfamily
I6L39_18570	COG0583	DNA-binding transcription factor activity
I6L39_18580	COG2050	protein possibly involved in aromatic compounds catabolism
I6L39_18590	COG0247	lactate metabolic process
I6L39_18590	COG0277	FAD linked oxidase domain protein
I6L39_18600	COG1253	flavin adenine dinucleotide binding
I6L39_18605	COG1902	pentaerythritol trinitrate reductase activity
I6L39_18615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L39_18620	COG0647	UMP catabolic process
I6L39_18630	COG0367	asparagine synthase
I6L39_18640	COG0625	glutathione transferase activity
I6L39_18650	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L39_18665	COG0564	pseudouridine synthase activity
I6L39_18670	COG5001	Diguanylate cyclase
I6L39_18675	COG0840	transmembrane signaling receptor activity
I6L39_18680	COG0318	PFAM AMP-dependent synthetase and ligase
I6L39_18725	COG2855	membrane
I6L39_18735	COG2814	Major facilitator Superfamily
I6L39_18740	COG3246	L-lysine catabolic process to acetate
I6L39_18745	COG2175	clavaminate synthase activity
I6L39_18755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L39_18780	COG0670	Belongs to the BI1 family
I6L39_18790	COG1289	transmembrane transporter activity
I6L39_18795	COG2920	part of a sulfur-relay system
I6L39_18800	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L39_18805	COG0285	dihydrofolate synthase activity
I6L39_18810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L39_18815	COG0101	tRNA pseudouridine synthase activity
I6L39_18825	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L39_18830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L39_18835	COG0671	phosphoesterase, PA-phosphatase related
I6L39_18840	COG1464	Belongs to the NlpA lipoprotein family
I6L39_18860	COG1119	ATPase activity
I6L39_18865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L39_18865	COG0574	Belongs to the PEP-utilizing enzyme family
I6L39_18870	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L39_18880	COG1113	amino acid transport
I6L39_18885	COG2135	peptidase activity
I6L39_18890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L39_18895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L39_18910	COG1196	nuclear chromosome segregation
I6L39_18950	COG0582	viral genome integration into host DNA
I6L39_18995	COG1242	4 iron, 4 sulfur cluster binding
I6L39_19000	COG0067	glutamate synthase
I6L39_19000	COG0069	glutamate synthase activity
I6L39_19000	COG0070	glutamate synthase
I6L39_19005	COG0493	'glutamate synthase
I6L39_19010	COG1126	abc transporter atp-binding protein
I6L39_19015	COG0765	amino acid transport
I6L39_19020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_19035	COG4104	PAAR repeat-containing protein
I6L39_19045	COG0513	Belongs to the DEAD box helicase family
I6L39_19080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L39_19085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L39_19090	COG0505	Belongs to the CarA family
I6L39_19100	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L39_19110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L39_19115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L39_19120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L39_19125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L39_19130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L39_19135	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6L39_19170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L39_19180	COG0023	Translation Initiation Factor
I6L39_19185	COG2119	membrane
I6L39_19215	COG2199	diguanylate cyclase activity
I6L39_19215	COG2203	Gaf domain
I6L39_19230	COG1204	response to ionizing radiation
I6L39_19235	COG2801	Transposase and inactivated derivatives
I6L39_19245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L39_19255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L39_19260	COG2261	transglycosylase associated protein
I6L39_19265	COG1309	transcriptional regulator
I6L39_19270	COG0604	alcohol dehydrogenase
I6L39_19285	COG0248	Ppx GppA phosphatase
I6L39_19345	COG0322	excinuclease ABC activity
I6L39_19350	COG2197	response regulator
I6L39_19355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L39_19360	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L39_19365	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L39_19370	COG1132	(ABC) transporter
I6L39_19375	COG0658	competence protein
I6L39_19375	COG2333	competence protein COMEC
I6L39_19390	COG0433	COG0433 Predicted ATPase
I6L39_19395	COG1448	Aminotransferase
I6L39_19410	COG1199	ATP-dependent helicase activity
I6L39_19420	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L39_19425	COG0477	Major facilitator Superfamily
I6L39_19430	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L39_19435	COG1785	Belongs to the alkaline phosphatase family
I6L39_19455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L39_19465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L39_19470	COG0765	amino acid transport
I6L39_19475	COG1126	abc transporter atp-binding protein
I6L39_19485	COG0531	amino acid
I6L39_19500	COG1253	flavin adenine dinucleotide binding
I6L39_19505	COG0704	Plays a role in the regulation of phosphate uptake
I6L39_19510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L39_19515	COG0581	inorganic phosphate transmembrane transporter activity
I6L39_19520	COG0573	inorganic phosphate transmembrane transporter activity
I6L39_19525	COG0590	tRNA wobble adenosine to inosine editing
I6L39_19535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L39_19555	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L39_19560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L39_19565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L39_19570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L39_19595	COG2716	regulation of RNA biosynthetic process
I6L39_19600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L39_19610	COG2239	Acts as a magnesium transporter
I6L39_19630	COG1706	bacterial-type flagellum-dependent cell motility
I6L39_19635	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L39_19650	COG1749	Flagellar hook protein flgE
I6L39_19665	COG1815	bacterial-type flagellum-dependent cell motility
I6L39_19670	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L39_19675	COG0835	chemotaxis
I6L39_19675	COG0784	Response regulator, receiver
I6L39_19680	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L39_19695	COG0622	Phosphoesterase
I6L39_19700	COG4166	transmembrane transport
I6L39_19725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L39_19730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L39_19735	COG1882	Formate acetyltransferase
I6L39_19740	COG1349	DNA-binding transcription factor activity
I6L39_19745	COG0697	spore germination
I6L39_19775	COG1278	Cold shock
I6L39_19815	COG3132	Protein of unknown function, DUF480
I6L39_19830	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L39_19840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L39_19850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L39_19860	COG1215	transferase activity, transferring glycosyl groups
I6L39_19895	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L39_19920	COG1737	Transcriptional regulator
I6L39_19925	COG0469	pyruvate kinase activity
I6L39_19935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_19940	COG1960	acyl-CoA dehydrogenase activity
I6L39_19950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L39_19960	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L39_19970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_19975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_19980	COG1309	transcriptional regulator
I6L39_19995	COG1946	Acyl-CoA thioesterase
I6L39_20010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L39_20020	COG0009	L-threonylcarbamoyladenylate synthase
I6L39_20030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L39_20035	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L39_20035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L39_20040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L39_20045	COG0134	indole-3-glycerol-phosphate synthase activity
I6L39_20045	COG0135	phosphoribosylanthranilate isomerase activity
I6L39_20050	COG0133	tryptophan synthase activity
I6L39_20055	COG0159	tryptophan synthase activity
I6L39_20090	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6L39_20095	COG2814	Major facilitator Superfamily
I6L39_20105	COG0109	protoheme IX farnesyltransferase activity
I6L39_20110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L39_20115	COG1845	cytochrome c oxidase, subunit III
I6L39_20120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L39_20125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L39_20130	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L39_20135	COG0583	DNA-binding transcription factor activity
I6L39_20155	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
I6L39_20165	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L39_20170	COG0745	RESPONSE REGULATOR receiver
I6L39_20180	COG0708	Exodeoxyribonuclease III
I6L39_20190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L39_20195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L39_20210	COG0095	Lipoate-protein ligase
I6L39_20220	COG0577	efflux transmembrane transporter activity
I6L39_20220	COG1136	(ABC) transporter