locus-tag	class	description
I6L40_00015	COG0840	transmembrane signaling receptor activity
I6L40_00020	COG3047	cAMP biosynthetic process
I6L40_00030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L40_00035	COG0629	single-stranded DNA binding
I6L40_00055	COG2252	PERMEase
I6L40_00060	COG2376	Dihydroxyacetone kinase
I6L40_00065	COG1461	Dihydroxyacetone kinase
I6L40_00070	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L40_00070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_00070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L40_00080	COG3284	Transcriptional regulator
I6L40_00085	COG0583	DNA-binding transcription factor activity
I6L40_00105	COG2957	Belongs to the agmatine deiminase family
I6L40_00120	COG0628	permease
I6L40_00140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L40_00145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L40_00170	COG0456	acetyltransferase
I6L40_00175	COG3133	Outer membrane lipoprotein
I6L40_00180	COG0004	ammonium transporteR
I6L40_00195	COG3932	Exopolysaccharide synthesis, ExoD
I6L40_00200	COG0814	amino acid
I6L40_00215	COG0110	maltose O-acetyltransferase activity
I6L40_00235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L40_00240	COG2022	thiamine diphosphate biosynthetic process
I6L40_00250	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L40_00255	COG0352	thiamine-phosphate diphosphorylase activity
I6L40_00260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L40_00265	COG0789	Transcriptional regulator
I6L40_00285	COG0745	RESPONSE REGULATOR receiver
I6L40_00290	COG0642	Histidine kinase
I6L40_00295	COG0189	ligase activity
I6L40_00300	COG1410	methionine synthase
I6L40_00300	COG0646	methionine synthase
I6L40_00340	COG0477	Major facilitator Superfamily
I6L40_00355	COG0312	modulator of DNA gyrase
I6L40_00360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L40_00370	COG3164	Protein of unknown function
I6L40_00375	COG1530	ribonuclease E activity
I6L40_00380	COG0424	maF-like protein
I6L40_00385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L40_00390	COG1792	Involved in formation and maintenance of cell shape
I6L40_00395	COG1077	Cell shape determining protein MreB Mrl
I6L40_00420	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6L40_00425	COG4969	Belongs to the N-Me-Phe pilin family
I6L40_00440	COG1459	type II secretion system
I6L40_00445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L40_00490	COG2200	EAL domain
I6L40_00490	COG2199	diguanylate cyclase activity
I6L40_00495	COG2200	EAL domain
I6L40_00505	COG0387	Pfam Sodium calcium exchanger
I6L40_00510	COG2986	histidine ammonia-lyase
I6L40_00515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L40_00520	COG0010	Belongs to the arginase family
I6L40_00525	COG1228	amidohydrolase
I6L40_00530	COG2188	Transcriptional regulator
I6L40_00535	COG0288	reversible hydration of carbon dioxide
I6L40_00545	COG2177	Part of the ABC transporter FtsEX involved in
I6L40_00550	COG2884	Cell division ATP-binding protein ftsE
I6L40_00555	COG0552	protein localization to endoplasmic reticulum
I6L40_00560	COG0742	ribosomal rna small subunit methyltransferase
I6L40_00585	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L40_00590	COG0583	DNA-binding transcription factor activity
I6L40_00595	COG4221	oxidoreductase activity
I6L40_00610	COG1770	oligopeptidase
I6L40_00625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L40_00635	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L40_00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L40_00655	COG2095	MarC family integral membrane protein
I6L40_00665	COG1301	dicarboxylic acid transport
I6L40_00690	COG3714	YhhN family
I6L40_00745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L40_00750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L40_00755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L40_00760	COG0049	tRNA binding
I6L40_00765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L40_00770	COG2168	tRNA wobble position uridine thiolation
I6L40_00775	COG2923	Belongs to the DsrF TusC family
I6L40_00780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L40_00790	COG2964	Protein conserved in bacteria
I6L40_00795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L40_00800	COG0085	RNA polymerase activity
I6L40_00805	COG0222	ribosome binding
I6L40_00810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L40_00815	COG0081	regulation of translation
I6L40_00820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L40_00825	COG0250	Participates in transcription elongation, termination and antitermination
I6L40_00840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L40_00865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L40_00870	COG0569	domain protein
I6L40_00875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L40_00880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L40_00890	COG4191	Histidine kinase
I6L40_00890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_00895	COG3005	denitrification pathway
I6L40_00900	COG0243	molybdopterin cofactor binding
I6L40_00930	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6L40_00945	COG2204	response regulator
I6L40_00955	COG2205	protein histidine kinase activity
I6L40_00970	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_00975	COG5413	integral membrane protein
I6L40_00985	COG1522	sequence-specific DNA binding
I6L40_00990	COG2502	aspartate--ammonia ligase
I6L40_00995	COG0542	response to heat
I6L40_01005	COG0564	pseudouridine synthase activity
I6L40_01010	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L40_01030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L40_01035	COG0463	Glycosyl transferase, family 2
I6L40_01040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L40_01040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L40_01045	COG0726	polysaccharide deacetylase
I6L40_01050	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6L40_01055	COG2076	Multidrug Resistance protein
I6L40_01060	COG2076	Multidrug Resistance protein
I6L40_01065	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L40_01075	COG3681	Belongs to the UPF0597 family
I6L40_01085	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L40_01090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L40_01095	COG1979	alcohol dehydrogenase
I6L40_01100	COG2207	Transcriptional regulator
I6L40_01105	COG3040	lipid binding
I6L40_01120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6L40_01140	COG0583	DNA-binding transcription factor activity
I6L40_01145	COG0688	phosphatidylethanolamine metabolic process
I6L40_01160	COG0540	Belongs to the ATCase OTCase family
I6L40_01165	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L40_01170	COG1438	arginine binding
I6L40_01175	COG1288	antiporter activity
I6L40_01180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L40_01210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L40_01220	COG3078	GTPase activator activity
I6L40_01230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L40_01240	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L40_01245	COG0408	coproporphyrinogen oxidase activity
I6L40_01250	COG0009	L-threonylcarbamoyladenylate synthase
I6L40_01260	COG0551	DNA topoisomerase type I activity
I6L40_01265	COG2922	Belongs to the Smg family
I6L40_01270	COG0758	DNA mediated transformation
I6L40_01275	COG1652	LysM domain
I6L40_01280	COG0242	peptide deformylase activity
I6L40_01285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L40_01290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L40_01290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L40_01295	COG0569	domain protein
I6L40_01300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L40_01305	COG1217	gtp-binding protein TYPA
I6L40_01310	COG0174	glutamine synthetase
I6L40_01325	COG2204	response regulator
I6L40_01330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L40_01335	COG1322	Protein conserved in bacteria
I6L40_01355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L40_01360	COG0583	DNA-binding transcription factor activity
I6L40_01365	COG0519	Catalyzes the synthesis of GMP from XMP
I6L40_01365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L40_01375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L40_01380	COG1396	sequence-specific DNA binding
I6L40_01385	COG1012	belongs to the aldehyde dehydrogenase family
I6L40_01395	COG2962	Rard protein
I6L40_01400	COG0840	transmembrane signaling receptor activity
I6L40_01405	COG2391	methyltransferase activity
I6L40_01430	COG0129	dihydroxy-acid dehydratase activity
I6L40_01440	COG3978	acetolactate synthase activity
I6L40_01450	COG0606	chelatase, subunit chli
I6L40_01455	COG0204	Acyl-transferase
I6L40_01460	COG0204	Acyl-transferase
I6L40_01465	COG1683	Conserved Protein
I6L40_01475	COG1335	isochorismatase
I6L40_01485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L40_01490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L40_01500	COG3084	Protein conserved in bacteria
I6L40_01505	COG5001	Diguanylate cyclase
I6L40_01505	COG4251	negative regulation of phosphorylation
I6L40_01505	COG3706	GGDEF domain
I6L40_01505	COG2203	Gaf domain
I6L40_01520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L40_01525	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L40_01530	COG1561	YicC-like family, N-terminal region
I6L40_01535	COG0583	DNA-binding transcription factor activity
I6L40_01550	COG0583	DNA-binding transcription factor activity
I6L40_01590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L40_01595	COG0385	Bile acid
I6L40_01600	COG0531	amino acid
I6L40_01605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L40_01610	COG0531	amino acid
I6L40_01615	COG2731	YhcH YjgK YiaL family protein
I6L40_01620	COG3250	beta-galactosidase activity
I6L40_01625	COG1609	Transcriptional regulator
I6L40_01660	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L40_01665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L40_01665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L40_01670	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L40_01675	COG3074	FtsZ-dependent cytokinesis
I6L40_01685	COG1045	serine acetyltransferase
I6L40_01695	COG0745	RESPONSE REGULATOR receiver
I6L40_01700	COG2205	protein histidine kinase activity
I6L40_01705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L40_01710	COG0534	Mate efflux family protein
I6L40_01725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L40_01730	COG2937	Belongs to the GPAT DAPAT family
I6L40_01735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L40_01740	COG3161	chorismate lyase activity
I6L40_01745	COG1580	Controls the rotational direction of flagella during chemotaxis
I6L40_01760	COG0604	alcohol dehydrogenase
I6L40_01765	COG1609	Transcriptional regulator
I6L40_01770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_01785	COG1519	Transferase
I6L40_01790	COG0859	PFAM glycosyl transferase family 9
I6L40_01795	COG0463	Glycosyl transferase, family 2
I6L40_01800	COG0859	PFAM glycosyl transferase family 9
I6L40_01805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L40_01810	COG2990	Protein conserved in bacteria
I6L40_01815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L40_01825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L40_01830	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L40_01835	COG2003	Belongs to the UPF0758 family
I6L40_01840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L40_01845	COG0756	dUTP diphosphatase activity
I6L40_01850	COG1309	transcriptional regulator
I6L40_01855	COG0668	transmembrane transport
I6L40_01860	COG0166	Belongs to the GPI family
I6L40_01865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L40_01920	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L40_01925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L40_01930	COG1739	Uncharacterized protein family UPF0029
I6L40_01935	COG0006	proline dipeptidase activity
I6L40_01940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L40_01945	COG1024	Enoyl-CoA hydratase
I6L40_01945	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L40_01950	COG0183	Belongs to the thiolase family
I6L40_01975	COG0425	Belongs to the sulfur carrier protein TusA family
I6L40_01980	COG0251	oxidation-reduction process
I6L40_01985	COG2885	chlorophyll binding
I6L40_01990	COG0840	transmembrane signaling receptor activity
I6L40_01995	COG2818	Glycosylase
I6L40_02000	COG0752	glycyl-tRNA synthetase alpha subunit
I6L40_02005	COG0751	glycine-tRNA ligase activity
I6L40_02015	COG5001	Diguanylate cyclase
I6L40_02015	COG2203	Gaf domain
I6L40_02015	COG4251	negative regulation of phosphorylation
I6L40_02015	COG3706	GGDEF domain
I6L40_02030	COG2188	Transcriptional regulator
I6L40_02075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L40_02090	COG2960	long-chain fatty acid transporting porin activity
I6L40_02095	COG5001	Diguanylate cyclase
I6L40_02095	COG5002	protein histidine kinase activity
I6L40_02105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L40_02120	COG3118	belongs to the thioredoxin family
I6L40_02125	COG0513	Belongs to the DEAD box helicase family
I6L40_02130	COG0248	Ppx GppA phosphatase
I6L40_02140	COG0742	ribosomal rna small subunit methyltransferase
I6L40_02145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_02160	COG3469	chitinase activity
I6L40_02170	COG0084	hydrolase, TatD family'
I6L40_02175	COG0805	protein transport
I6L40_02180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L40_02190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L40_02200	COG2226	methyltransferase
I6L40_02210	COG0402	S-adenosylhomocysteine deaminase activity
I6L40_02215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L40_02250	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L40_02255	COG0848	biopolymer transport protein
I6L40_02260	COG0811	peptide transport
I6L40_02265	COG0811	peptide transport
I6L40_02275	COG2771	luxR family
I6L40_02280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L40_02285	COG1349	DNA-binding transcription factor activity
I6L40_02290	COG0745	RESPONSE REGULATOR receiver
I6L40_02295	COG2205	protein histidine kinase activity
I6L40_02310	COG4452	Inner membrane protein CreD
I6L40_02315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L40_02320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L40_02325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L40_02330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L40_02335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L40_02340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L40_02345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L40_02355	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L40_02365	COG1475	DNA binding
I6L40_02370	COG1192	Involved in chromosome partitioning
I6L40_02375	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L40_02380	COG0445	tRNA wobble uridine modification
I6L40_02385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L40_02395	COG4615	Cyclic peptide transporter
I6L40_02400	COG1120	ATPase activity
I6L40_02405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L40_02410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L40_02415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L40_02420	COG0706	membrane insertase activity
I6L40_02425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L40_02430	COG0594	ribonuclease P activity
I6L40_02435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L40_02440	COG1126	abc transporter atp-binding protein
I6L40_02455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L40_02460	COG0592	DNA-directed DNA polymerase activity
I6L40_02485	COG2378	regulation of single-species biofilm formation
I6L40_02495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L40_02500	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L40_02505	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L40_02510	COG3977	Valine--pyruvate aminotransferase
I6L40_02525	COG2814	Major facilitator Superfamily
I6L40_02530	COG0745	RESPONSE REGULATOR receiver
I6L40_02535	COG2205	protein histidine kinase activity
I6L40_02555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L40_02560	COG4191	Histidine kinase
I6L40_02560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_02565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_02570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_02575	COG1309	transcriptional regulator
I6L40_02610	COG0561	phosphatase activity
I6L40_02615	COG2267	carboxylic ester hydrolase activity
I6L40_02625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L40_02630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L40_02635	COG1758	RNA polymerase activity
I6L40_02645	COG0859	PFAM glycosyl transferase family 9
I6L40_02650	COG3642	lipopolysaccharide core region biosynthetic process
I6L40_02690	COG0589	response to stress
I6L40_02695	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L40_02700	COG1528	Iron-storage protein
I6L40_02705	COG2081	HI0933 family
I6L40_02710	COG3275	phosphorelay sensor kinase activity
I6L40_02715	COG3279	Response regulator of the LytR AlgR family
I6L40_02720	COG2223	nitrite transmembrane transporter activity
I6L40_02725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L40_02730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L40_02745	COG0583	DNA-binding transcription factor activity
I6L40_02750	COG4206	TonB-dependent receptor
I6L40_02755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L40_02790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L40_02795	COG2166	iron-sulfur cluster assembly
I6L40_02800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L40_02815	COG3245	cytochrome
I6L40_02820	COG1063	alcohol dehydrogenase
I6L40_02825	COG0156	8-amino-7-oxononanoate synthase activity
I6L40_02835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L40_02875	COG1280	lysine exporter protein (LysE YggA)
I6L40_02910	COG1943	Transposase
I6L40_02930	COG0210	DNA helicase
I6L40_02935	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L40_02940	COG3845	ABC transporter
I6L40_02945	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L40_02950	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L40_02955	COG0737	Belongs to the 5'-nucleotidase family
I6L40_02965	COG2239	Acts as a magnesium transporter
I6L40_02975	COG3177	Filamentation induced by cAMP protein fic
I6L40_02980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L40_02980	COG1648	precorrin-2 dehydrogenase activity
I6L40_02985	COG2116	formate transmembrane transporter activity
I6L40_02995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L40_03000	COG0842	Transport permease protein
I6L40_03005	COG0842	Transport permease protein
I6L40_03010	COG1131	(ABC) transporter
I6L40_03015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_03025	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L40_03030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L40_03050	COG1595	DNA-templated transcription, initiation
I6L40_03060	COG1968	undecaprenyl-diphosphatase activity
I6L40_03065	COG2017	converts alpha-aldose to the beta-anomer
I6L40_03070	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L40_03075	COG1085	galactose-1-phosphate uridylyltransferase
I6L40_03080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L40_03085	COG1609	Transcriptional regulator
I6L40_03090	COG3250	beta-galactosidase activity
I6L40_03115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L40_03130	COG0366	Alpha amylase catalytic
I6L40_03145	COG0443	Heat shock 70 kDa protein
I6L40_03150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L40_03155	COG3045	CreA protein
I6L40_03175	COG0174	glutamine synthetase
I6L40_03195	COG3842	ATPase activity
I6L40_03200	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L40_03205	COG1177	transmembrane transport
I6L40_03210	COG2258	MOSC domain
I6L40_03225	COG2050	protein possibly involved in aromatic compounds catabolism
I6L40_03230	COG0514	ATP-dependent DNA helicase (RecQ)
I6L40_03240	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L40_03250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L40_03255	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L40_03270	COG0254	rRNA binding
I6L40_03275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L40_03285	COG0702	epimerase
I6L40_03290	COG0814	amino acid
I6L40_03295	COG0281	malic enzyme
I6L40_03300	COG1295	ribonuclease BN
I6L40_03305	COG1490	D-aminoacyl-tRNA deacylase activity
I6L40_03310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6L40_03315	COG0456	acetyltransferase
I6L40_03325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L40_03330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L40_03335	COG2610	gluconate transmembrane transporter activity
I6L40_03340	COG3265	gluconokinase activity
I6L40_03350	COG0800	Aldolase
I6L40_03365	COG1609	Transcriptional regulator
I6L40_03375	COG4942	peptidase
I6L40_03380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L40_03385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L40_03390	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L40_03395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L40_03400	COG0316	Belongs to the HesB IscA family
I6L40_03400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L40_03405	COG1040	competence protein
I6L40_03410	COG0596	Alpha beta hydrolase
I6L40_03430	COG2183	response to ionizing radiation
I6L40_03435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L40_03455	COG0051	transcription antitermination factor activity, RNA binding
I6L40_03460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L40_03465	COG0088	Forms part of the polypeptide exit tunnel
I6L40_03470	COG0089	rRNA binding
I6L40_03475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L40_03480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L40_03485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L40_03490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L40_03495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L40_03500	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L40_03505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L40_03510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L40_03515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L40_03520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L40_03525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L40_03530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L40_03535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L40_03540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L40_03545	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L40_03550	COG1841	ribosomal large subunit assembly
I6L40_03555	COG0200	Binds to the 23S rRNA
I6L40_03560	COG0201	protein transport
I6L40_03565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L40_03570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L40_03575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L40_03580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L40_03585	COG0202	RNA polymerase activity
I6L40_03590	COG0203	ribosomal protein L17
I6L40_03620	COG4771	TonB-dependent receptor
I6L40_03625	COG3706	GGDEF domain
I6L40_03645	COG0583	DNA-binding transcription factor activity
I6L40_03655	COG1741	Belongs to the pirin family
I6L40_03660	COG2259	Doxx family
I6L40_03665	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L40_03670	COG1074	ATP-dependent DNA helicase activity
I6L40_03675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L40_03690	COG2203	Gaf domain
I6L40_03690	COG2199	diguanylate cyclase activity
I6L40_03700	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L40_03725	COG1175	transmembrane transport
I6L40_03735	COG3842	ATPase activity
I6L40_03765	COG2873	o-acetylhomoserine
I6L40_03790	COG5380	lipid catabolic process
I6L40_03795	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L40_03800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L40_03825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L40_03825	COG0456	acetyltransferase
I6L40_03830	COG0454	-acetyltransferase
I6L40_03830	COG0456	acetyltransferase
I6L40_03855	COG2927	DNA polymerase III (CHI subunit)
I6L40_03860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L40_03865	COG0795	lipopolysaccharide-transporting ATPase activity
I6L40_03870	COG0795	lipopolysaccharide-transporting ATPase activity
I6L40_03900	COG1686	Belongs to the peptidase S11 family
I6L40_03925	COG1494	fructose-1,6-bisphosphatase
I6L40_03940	COG2959	enzyme of heme biosynthesis
I6L40_03950	COG0181	hydroxymethylbilane synthase activity
I6L40_03955	COG3072	Adenylate cyclase
I6L40_03960	COG0400	carboxylic ester hydrolase activity
I6L40_03965	COG1965	Belongs to the frataxin family
I6L40_03975	COG0019	diaminopimelate decarboxylase activity
I6L40_03980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L40_03995	COG1011	Hydrolase
I6L40_04000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L40_04010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L40_04015	COG3028	Belongs to the UPF0307 family
I6L40_04020	COG0312	modulator of DNA gyrase
I6L40_04025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L40_04030	COG5007	Belongs to the BolA IbaG family
I6L40_04040	COG2854	intermembrane phospholipid transfer
I6L40_04045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L40_04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L40_04055	COG1127	ABC transporter
I6L40_04060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L40_04060	COG0517	IMP dehydrogenase activity
I6L40_04065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L40_04075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L40_04080	COG1137	ATPase activity
I6L40_04085	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6L40_04095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_04100	COG1660	Displays ATPase and GTPase activities
I6L40_04105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_04110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_04110	COG3711	transcriptional antiterminator
I6L40_04125	COG3964	amidohydrolase
I6L40_04155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L40_04160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L40_04170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L40_04175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L40_04180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L40_04185	COG0723	plastoquinol--plastocyanin reductase activity
I6L40_04190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L40_04195	COG2857	Cytochrome c1
I6L40_04200	COG0625	glutathione transferase activity
I6L40_04205	COG2969	positive regulation of protein catabolic process
I6L40_04215	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L40_04220	COG0792	nuclease activity
I6L40_04225	COG3107	peptidoglycan biosynthetic process
I6L40_04230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L40_04280	COG1677	Flagellar hook-basal body complex protein FliE
I6L40_04290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L40_04315	COG2747	anti-sigma28 factor FlgM
I6L40_04325	COG1815	bacterial-type flagellum-dependent cell motility
I6L40_04350	COG4786	Flagellar basal body rod
I6L40_04355	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L40_04360	COG1706	bacterial-type flagellum-dependent cell motility
I6L40_04370	COG4786	Flagellar basal body rod
I6L40_04370	COG1256	bacterial-type flagellum assembly
I6L40_04375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L40_04390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L40_04395	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L40_04420	COG1191	sigma factor activity
I6L40_04425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L40_04430	COG1360	Flagellar Motor Protein
I6L40_04435	COG0741	lytic transglycosylase activity
I6L40_04435	COG1388	LysM domain
I6L40_04445	COG2001	Belongs to the MraZ family
I6L40_04450	COG0275	rRNA processing
I6L40_04455	COG3116	cell division
I6L40_04460	COG0768	penicillin binding
I6L40_04465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L40_04470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L40_04475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L40_04480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L40_04485	COG0772	Belongs to the SEDS family
I6L40_04490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L40_04495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L40_04505	COG0849	cell division
I6L40_04510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L40_04515	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L40_04525	COG0653	protein targeting
I6L40_04530	COG0494	nUDIX hydrolase
I6L40_04535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L40_04540	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L40_04555	COG1459	type II secretion system
I6L40_04560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L40_04585	COG2186	Transcriptional regulator
I6L40_04590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L40_04595	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L40_04600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L40_04605	COG0840	transmembrane signaling receptor activity
I6L40_04610	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L40_04615	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L40_04620	COG2200	EAL domain
I6L40_04630	COG0523	cobalamin synthesis protein
I6L40_04635	COG0477	Major facilitator Superfamily
I6L40_04645	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L40_04650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L40_04675	COG3314	Sporulation integral membrane protein YlbJ
I6L40_04690	COG0165	Argininosuccinate lyase
I6L40_04695	COG0137	argininosuccinate synthase activity
I6L40_04705	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L40_04710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L40_04720	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L40_04750	COG0583	DNA-binding transcription factor activity
I6L40_04770	COG1380	Effector of murein hydrolase LrgA
I6L40_04775	COG1346	cytolysis
I6L40_04785	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L40_04790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L40_04795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L40_04800	COG1546	Belongs to the CinA family
I6L40_04805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L40_04815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L40_04820	COG0527	aspartate kinase activity
I6L40_04825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L40_04860	COG1686	Belongs to the peptidase S11 family
I6L40_04865	COG0586	Pfam SNARE associated Golgi protein
I6L40_04870	COG1253	flavin adenine dinucleotide binding
I6L40_04875	COG0252	asparaginase activity
I6L40_04895	COG1263	PTS System
I6L40_04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_04900	COG0366	Alpha amylase catalytic
I6L40_04905	COG0110	maltose O-acetyltransferase activity
I6L40_04915	COG0564	pseudouridine synthase activity
I6L40_04920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L40_04950	COG1042	CoA-binding domain protein
I6L40_04950	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L40_04950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L40_04975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L40_04980	COG0038	chloride channel
I6L40_04990	COG0316	Belongs to the HesB IscA family
I6L40_04995	COG1757	Na H antiporter
I6L40_05035	COG0297	glycogen (starch) synthase activity
I6L40_05040	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L40_05045	COG2813	Specifically methylates the guanine in position
I6L40_05050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L40_05055	COG3025	triphosphatase activity
I6L40_05060	COG1392	Phosphate transport regulator
I6L40_05065	COG0306	phosphate transporter
I6L40_05070	COG0460	homoserine dehydrogenase
I6L40_05070	COG0527	aspartate kinase activity
I6L40_05075	COG0626	cystathionine gamma-synthase activity
I6L40_05090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L40_05095	COG0814	amino acid
I6L40_05100	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L40_05105	COG0494	nUDIX hydrolase
I6L40_05110	COG1011	Hydrolase
I6L40_05125	COG0110	maltose O-acetyltransferase activity
I6L40_05130	COG3174	membrane
I6L40_05135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L40_05145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L40_05150	COG4208	sulfate ABC transporter
I6L40_05155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L40_05160	COG0583	DNA-binding transcription factor activity
I6L40_05165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L40_05170	COG0765	amino acid transport
I6L40_05180	COG1126	abc transporter atp-binding protein
I6L40_05185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_05190	COG3397	chitin binding
I6L40_05195	COG0840	transmembrane signaling receptor activity
I6L40_05210	COG0543	2 iron, 2 sulfur cluster binding
I6L40_05210	COG0633	Ferredoxin
I6L40_05225	COG1328	CTP reductase activity
I6L40_05230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L40_05245	COG1448	Aminotransferase
I6L40_05285	COG0513	Belongs to the DEAD box helicase family
I6L40_05315	COG3112	Uncharacterised protein family (UPF0231)
I6L40_05320	COG3835	regulator
I6L40_05325	COG2610	gluconate transmembrane transporter activity
I6L40_05330	COG1929	Belongs to the glycerate kinase type-1 family
I6L40_05345	COG0583	DNA-binding transcription factor activity
I6L40_05350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L40_05360	COG1872	DUF167
I6L40_05365	COG0762	integral membrane protein
I6L40_05370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L40_05375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L40_05390	COG3022	response to hydroperoxide
I6L40_05410	COG0347	Belongs to the P(II) protein family
I6L40_05415	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L40_05425	COG3842	ATPase activity
I6L40_05430	COG2837	iron assimilation
I6L40_05435	COG1438	arginine binding
I6L40_05440	COG1126	abc transporter atp-binding protein
I6L40_05445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_05450	COG4215	(ABC) transporter
I6L40_05455	COG4160	amino acid transport
I6L40_05460	COG0039	L-malate dehydrogenase activity
I6L40_05465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L40_05470	COG1017	nitric oxide dioxygenase activity
I6L40_05470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L40_05480	COG4536	flavin adenine dinucleotide binding
I6L40_05485	COG4137	Cytochrome C assembly protein
I6L40_05490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L40_05495	COG0228	four-way junction DNA binding
I6L40_05500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L40_05505	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L40_05510	COG0335	large ribosomal subunit rRNA binding
I6L40_05525	COG1051	belongs to the nudix hydrolase family
I6L40_05530	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6L40_05535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L40_05540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L40_05545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L40_05555	COG0583	DNA-binding transcription factor activity
I6L40_05560	COG0640	Transcriptional regulator
I6L40_05565	COG0268	Binds directly to 16S ribosomal RNA
I6L40_05570	COG0728	peptidoglycan biosynthetic process
I6L40_05575	COG0196	riboflavin kinase activity
I6L40_05580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L40_05585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L40_05590	COG1047	Peptidyl-prolyl cis-trans
I6L40_05595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L40_05630	COG4969	Belongs to the N-Me-Phe pilin family
I6L40_05635	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L40_05635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L40_05650	COG1854	S-ribosylhomocysteine lyase activity
I6L40_05660	COG2165	general secretion pathway protein
I6L40_05665	COG0084	hydrolase, TatD family'
I6L40_05670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L40_05680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L40_05685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L40_05690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L40_05695	COG0813	purine-nucleoside phosphorylase activity
I6L40_05705	COG0560	Phosphoserine phosphatase
I6L40_05720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L40_05730	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
I6L40_05735	COG0776	regulation of translation
I6L40_05750	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L40_05755	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L40_05760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L40_05765	COG0359	binds to the 23S rRNA
I6L40_05770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L40_05795	COG1238	metal cluster binding
I6L40_05800	COG0612	Peptidase, M16
I6L40_05805	COG2918	glutathione biosynthetic process
I6L40_05810	COG1022	Amp-dependent synthetase and ligase
I6L40_05815	COG0456	acetyltransferase
I6L40_05830	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L40_05845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L40_05855	COG0477	Major facilitator Superfamily
I6L40_05860	COG0583	DNA-binding transcription factor activity
I6L40_05870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L40_05875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L40_05885	COG0673	inositol 2-dehydrogenase activity
I6L40_05895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L40_05900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L40_05905	COG3036	rescue of stalled ribosome
I6L40_05915	COG0138	bifunctional purine biosynthesis protein purh
I6L40_05920	COG0151	Belongs to the GarS family
I6L40_05940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L40_05945	COG0358	DNA primase activity
I6L40_05950	COG1610	YqeY-like protein
I6L40_05955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L40_05960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L40_05965	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L40_05970	COG1027	Aspartate ammonia-lyase
I6L40_05975	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L40_05980	COG0534	Mate efflux family protein
I6L40_05985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L40_05990	COG0459	protein refolding
I6L40_06040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L40_06045	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L40_06050	COG1178	ABC-type Fe3 transport system permease component
I6L40_06070	COG0066	3-isopropylmalate dehydratase activity
I6L40_06075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L40_06080	COG0473	3-isopropylmalate dehydrogenase activity
I6L40_06085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L40_06095	COG0671	phosphoesterase, PA-phosphatase related
I6L40_06110	COG0028	Belongs to the TPP enzyme family
I6L40_06115	COG0440	acetolactate synthase activity
I6L40_06170	COG3675	Pfam Lipase (class 3)
I6L40_06205	COG3311	Transcriptional regulator
I6L40_06245	COG2003	Belongs to the UPF0758 family
I6L40_06315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L40_06330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_06360	COG0745	RESPONSE REGULATOR receiver
I6L40_06365	COG3104	oligopeptide transport
I6L40_06370	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L40_06375	COG1555	photosystem II stabilization
I6L40_06380	COG0280	phosphate acetyltransferase
I6L40_06380	COG0857	belongs to the CobB CobQ family
I6L40_06385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L40_06395	COG3013	Belongs to the UPF0304 family
I6L40_06400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L40_06405	COG2716	regulation of RNA biosynthetic process
I6L40_06410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L40_06415	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L40_06420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L40_06455	COG5002	protein histidine kinase activity
I6L40_06455	COG2198	Histidine kinase
I6L40_06455	COG0784	Response regulator, receiver
I6L40_06480	COG0840	transmembrane signaling receptor activity
I6L40_06490	COG1464	Belongs to the NlpA lipoprotein family
I6L40_06495	COG2011	ABC-type metal ion transport system permease component
I6L40_06500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L40_06520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L40_06520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L40_06525	COG0802	atpase or kinase
I6L40_06535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L40_06540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L40_06545	COG1923	regulation of RNA biosynthetic process
I6L40_06550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L40_06555	COG0330	HflC and HflK could
I6L40_06560	COG0330	HflC and HflK could
I6L40_06565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L40_06570	COG0142	geranyltranstransferase activity
I6L40_06575	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L40_06580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L40_06585	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L40_06590	COG3314	Sporulation integral membrane protein YlbJ
I6L40_06595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L40_06605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L40_06610	COG2967	ApaG domain
I6L40_06615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L40_06620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L40_06625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L40_06630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L40_06635	COG3178	'Phosphotransferase
I6L40_06640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L40_06645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L40_06650	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L40_06655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L40_06660	COG1073	alpha beta
I6L40_06675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L40_06690	COG4628	conserved protein (DUF2132)
I6L40_06695	COG0688	phosphatidylethanolamine metabolic process
I6L40_06700	COG1162	GTPase activity
I6L40_06705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L40_06745	COG1278	Cold shock
I6L40_06755	COG0840	transmembrane signaling receptor activity
I6L40_06760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L40_06765	COG2252	PERMEase
I6L40_06775	COG0488	(ABC) transporter
I6L40_06790	COG0741	lytic transglycosylase activity
I6L40_06800	COG3416	Protein conserved in bacteria
I6L40_06820	COG4608	Belongs to the ABC transporter superfamily
I6L40_06825	COG0444	Belongs to the ABC transporter superfamily
I6L40_06835	COG4239	(ABC) transporter, permease
I6L40_06840	COG4174	ABC transporter (Permease)
I6L40_06860	COG0811	peptide transport
I6L40_06865	COG0811	peptide transport
I6L40_06870	COG0848	biopolymer transport protein
I6L40_06890	COG0616	signal peptide processing
I6L40_06895	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L40_06895	COG1902	pentaerythritol trinitrate reductase activity
I6L40_06900	COG0778	Nitroreductase
I6L40_06910	COG2264	protein methyltransferase activity
I6L40_06915	COG0604	alcohol dehydrogenase
I6L40_06920	COG0583	DNA-binding transcription factor activity
I6L40_06925	COG1263	PTS System
I6L40_06925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_06925	COG2190	(PTS) system
I6L40_06930	COG4145	pantothenate transmembrane transporter activity
I6L40_06935	COG3924	membrane
I6L40_06940	COG0439	Biotin carboxylase
I6L40_06945	COG0511	ligase activity, forming carbon-carbon bonds
I6L40_06950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L40_06955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L40_06975	COG3381	protein complex oligomerization
I6L40_06990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L40_07000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L40_07005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L40_07005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L40_07025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L40_07030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L40_07035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L40_07045	COG4166	transmembrane transport
I6L40_07050	COG0601	transmembrane transport
I6L40_07060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L40_07065	COG0142	geranyltranstransferase activity
I6L40_07070	COG1722	exodeoxyribonuclease VII activity
I6L40_07075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L40_07080	COG1360	Flagellar Motor Protein
I6L40_07080	COG1360	Flagellar Motor Protein
I6L40_07095	COG1534	Rna-binding protein
I6L40_07100	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L40_07110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L40_07115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L40_07120	COG0149	triose-phosphate isomerase activity
I6L40_07125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L40_07140	COG0779	Required for maturation of 30S ribosomal subunits
I6L40_07145	COG0195	Participates in both transcription termination and antitermination
I6L40_07150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L40_07155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L40_07160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L40_07165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L40_07170	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L40_07175	COG2201	protein-glutamate methylesterase activity
I6L40_07180	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6L40_07190	COG0840	transmembrane signaling receptor activity
I6L40_07195	COG0835	chemotaxis
I6L40_07205	COG0643	Histidine kinase
I6L40_07205	COG2198	Histidine kinase
I6L40_07215	COG0745	RESPONSE REGULATOR receiver
I6L40_07225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L40_07235	COG1280	lysine exporter protein (LysE YggA)
I6L40_07240	COG0826	peptidase U32
I6L40_07245	COG0737	Belongs to the 5'-nucleotidase family
I6L40_07250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L40_07265	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L40_07290	COG0300	oxidoreductase activity
I6L40_07300	COG0840	transmembrane signaling receptor activity
I6L40_07330	COG0077	Prephenate dehydratase
I6L40_07330	COG1605	Chorismate mutase
I6L40_07360	COG3272	Protein of unknown function (DUF1722)
I6L40_07365	COG0789	Transcriptional regulator
I6L40_07370	COG0415	Belongs to the DNA photolyase family
I6L40_07380	COG0300	oxidoreductase activity
I6L40_07395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L40_07425	COG1477	protein flavinylation
I6L40_07430	COG2871	sodium ion transport
I6L40_07435	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L40_07440	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L40_07445	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L40_07450	COG1805	sodium ion transport
I6L40_07455	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L40_07460	COG0271	Belongs to the BolA IbaG family
I6L40_07465	COG2813	Specifically methylates the guanine in position
I6L40_07475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L40_07485	COG3248	Nucleoside-binding outer membrane protein
I6L40_07490	COG1666	GTP binding
I6L40_07495	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L40_07510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L40_07515	COG0840	transmembrane signaling receptor activity
I6L40_07520	COG0583	DNA-binding transcription factor activity
I6L40_07530	COG2363	Small membrane protein
I6L40_07535	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L40_07545	COG0473	3-isopropylmalate dehydrogenase activity
I6L40_07550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L40_07555	COG1611	Belongs to the LOG family
I6L40_07570	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L40_07570	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L40_07580	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L40_07605	COG3098	single-species biofilm formation
I6L40_07610	COG0564	pseudouridine synthase activity
I6L40_07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_07630	COG1263	PTS System
I6L40_07640	COG2171	N-acyltransferase activity
I6L40_07650	COG0024	Methionine aminopeptidase
I6L40_07655	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L40_07660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L40_07665	COG0528	UMP kinase activity
I6L40_07670	COG0233	cytoplasmic translational termination
I6L40_07675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L40_07680	COG0575	Belongs to the CDS family
I6L40_07685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L40_07690	COG0750	zinc metalloprotease
I6L40_07695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L40_07705	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L40_07710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L40_07715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L40_07720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L40_07725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L40_07735	COG0825	malonyl-CoA metabolic process
I6L40_07745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L40_07750	COG1115	amino acid carrier protein
I6L40_07765	COG0714	Associated with various cellular activities
I6L40_07800	COG3104	oligopeptide transport
I6L40_07805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L40_07810	COG1678	Uncharacterized ACR, COG1678
I6L40_07820	COG0189	ligase activity
I6L40_07825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L40_07835	COG3091	SprT-like family
I6L40_07845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L40_07855	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_07855	COG3321	synthase
I6L40_07855	COG0604	alcohol dehydrogenase
I6L40_07860	COG0583	DNA-binding transcription factor activity
I6L40_07890	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L40_07895	COG0739	heme binding
I6L40_07900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L40_07930	COG0814	amino acid
I6L40_07950	COG0531	amino acid
I6L40_07955	COG3710	Transcriptional regulator
I6L40_07965	COG0531	amino acid
I6L40_07970	COG1982	Orn Lys Arg decarboxylase major
I6L40_07975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L40_07985	COG3590	peptidase
I6L40_07995	COG2203	Gaf domain
I6L40_07995	COG2199	diguanylate cyclase activity
I6L40_08030	COG0366	Alpha amylase catalytic
I6L40_08045	COG0463	Glycosyl transferase, family 2
I6L40_08055	COG2989	Protein conserved in bacteria
I6L40_08060	COG3108	Peptidase M15
I6L40_08070	COG2860	membrane
I6L40_08080	COG1196	nuclear chromosome segregation
I6L40_08085	COG3115	cell septum assembly
I6L40_08090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L40_08100	COG1328	CTP reductase activity
I6L40_08105	COG0602	queuosine metabolic process
I6L40_08150	COG0281	malic enzyme
I6L40_08155	COG3290	protein histidine kinase activity
I6L40_08165	COG0697	spore germination
I6L40_08175	COG3706	GGDEF domain
I6L40_08180	COG0346	lactoylglutathione lyase activity
I6L40_08185	COG0745	RESPONSE REGULATOR receiver
I6L40_08190	COG5002	protein histidine kinase activity
I6L40_08215	COG3142	Participates in the control of copper homeostasis
I6L40_08220	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L40_08235	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6L40_08255	COG0019	diaminopimelate decarboxylase activity
I6L40_08260	COG1115	amino acid carrier protein
I6L40_08265	COG2233	PERMEase
I6L40_08280	COG0534	Mate efflux family protein
I6L40_08290	COG0281	malic enzyme
I6L40_08300	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6L40_08300	COG2885	chlorophyll binding
I6L40_08320	COG0531	amino acid
I6L40_08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L40_08330	COG3706	GGDEF domain
I6L40_08335	COG1566	PFAM secretion protein HlyD family protein
I6L40_08340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_08345	COG1032	radical SAM domain protein
I6L40_08375	COG0583	DNA-binding transcription factor activity
I6L40_08385	COG0673	inositol 2-dehydrogenase activity
I6L40_08390	COG2920	part of a sulfur-relay system
I6L40_08395	COG1289	transmembrane transporter activity
I6L40_08400	COG0670	Belongs to the BI1 family
I6L40_08415	COG3623	hexulose-6-phosphate isomerase
I6L40_08420	COG0561	phosphatase activity
I6L40_08445	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6L40_08455	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L40_08465	COG3156	type II secretion system protein K
I6L40_08470	COG4795	General secretion pathway protein
I6L40_08475	COG2165	general secretion pathway protein
I6L40_08485	COG2165	general secretion pathway protein
I6L40_08490	COG1459	type II secretion system
I6L40_08495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L40_08500	COG1450	Type ii and iii secretion system protein
I6L40_08515	COG3267	Type II secretory pathway component ExeA
I6L40_08515	COG3409	Peptidoglycan-binding domain 1 protein
I6L40_08520	COG2770	Histidine kinase
I6L40_08520	COG3437	response regulator, receiver
I6L40_08535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L40_08540	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L40_08545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_08555	COG2190	(PTS) system
I6L40_08565	COG3264	Mechanosensitive ion channel
I6L40_08565	COG1196	nuclear chromosome segregation
I6L40_08570	COG0469	pyruvate kinase activity
I6L40_08580	COG3384	dioxygenase
I6L40_08585	COG0419	ATPase involved in DNA repair
I6L40_08590	COG0420	3'-5' exonuclease activity
I6L40_08600	COG2974	May be involved in recombination
I6L40_08610	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L40_08620	COG0531	amino acid
I6L40_08630	COG0531	amino acid
I6L40_08645	COG1917	Cupin 2, conserved barrel domain protein
I6L40_08645	COG1396	sequence-specific DNA binding
I6L40_08650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_08675	COG3152	Membrane
I6L40_08680	COG3161	chorismate lyase activity
I6L40_08705	COG1720	tRNA m6t6A37 methyltransferase activity
I6L40_08725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L40_08730	COG4988	ABC transporter
I6L40_08745	COG0745	RESPONSE REGULATOR receiver
I6L40_08755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L40_08770	COG0640	Transcriptional regulator
I6L40_08785	COG0798	PFAM Bile acid sodium symporter
I6L40_08795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L40_08800	COG1988	membrane-bound metal-dependent
I6L40_08830	COG0159	tryptophan synthase activity
I6L40_08835	COG0133	tryptophan synthase activity
I6L40_08840	COG0135	phosphoribosylanthranilate isomerase activity
I6L40_08840	COG0134	indole-3-glycerol-phosphate synthase activity
I6L40_08845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L40_08850	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L40_08850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L40_08855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L40_08865	COG0009	L-threonylcarbamoyladenylate synthase
I6L40_08875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L40_08935	COG1993	acr, cog1993
I6L40_08940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L40_08950	COG1946	Acyl-CoA thioesterase
I6L40_08955	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L40_08960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L40_08970	COG0083	homoserine kinase activity
I6L40_08975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L40_08990	COG0813	purine-nucleoside phosphorylase activity
I6L40_09015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L40_09035	COG2132	Multicopper oxidase
I6L40_09050	COG5002	protein histidine kinase activity
I6L40_09055	COG0745	RESPONSE REGULATOR receiver
I6L40_09065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_09070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_09075	COG1538	Outer membrane efflux protein
I6L40_09090	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L40_09100	COG5642	Protein of unknown function (DUF2384)
I6L40_09105	COG2199	diguanylate cyclase activity
I6L40_09105	COG2203	Gaf domain
I6L40_09120	COG2199	diguanylate cyclase activity
I6L40_09120	COG2203	Gaf domain
I6L40_09130	COG3706	GGDEF domain
I6L40_09135	COG2197	response regulator
I6L40_09140	COG3604	Transcriptional regulator
I6L40_09145	COG0426	domain, Protein
I6L40_09145	COG1773	rubredoxin
I6L40_09150	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L40_09210	COG1309	transcriptional regulator
I6L40_09215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_09220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_09255	COG1086	Polysaccharide biosynthesis protein
I6L40_09280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L40_09295	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L40_09300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L40_09310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L40_09325	COG1538	Outer membrane efflux protein
I6L40_09330	COG1136	(ABC) transporter
I6L40_09330	COG0577	efflux transmembrane transporter activity
I6L40_09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_09340	COG1227	inorganic diphosphatase activity
I6L40_09345	COG0497	DNA recombination
I6L40_09350	COG1486	melibiose metabolic process
I6L40_09355	COG0583	DNA-binding transcription factor activity
I6L40_09360	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L40_09365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L40_09370	COG0443	Heat shock 70 kDa protein
I6L40_09375	COG0484	heat shock protein binding
I6L40_09380	COG1285	pathogenesis
I6L40_09390	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L40_09425	COG5001	Diguanylate cyclase
I6L40_09430	COG0095	Lipoate-protein ligase
I6L40_09440	COG0702	epimerase
I6L40_09445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L40_09450	COG1454	alcohol dehydrogenase
I6L40_09460	COG0564	pseudouridine synthase activity
I6L40_09465	COG1957	nucleoside hydrolase
I6L40_09490	COG1280	lysine exporter protein (LysE YggA)
I6L40_09505	COG3263	regulation of cellular component size
I6L40_09515	COG1876	peptidase activity
I6L40_09520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L40_09525	COG1393	Belongs to the ArsC family
I6L40_09535	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L40_09550	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L40_09560	COG0017	Asparaginyl-tRNA synthetase
I6L40_09575	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L40_09580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L40_09585	COG0156	8-amino-7-oxononanoate synthase activity
I6L40_09590	COG2226	methyltransferase
I6L40_09590	COG1073	alpha beta
I6L40_09595	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L40_09600	COG0501	Belongs to the peptidase M48B family
I6L40_09605	COG0633	Ferredoxin
I6L40_09605	COG3217	Mosc domain protein beta barrel domain protein
I6L40_09605	COG0633	Ferredoxin
I6L40_09605	COG3217	Mosc domain protein beta barrel domain protein
I6L40_09615	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L40_09615	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L40_09615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L40_09615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L40_09625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L40_09630	COG1607	acyl-coa hydrolase
I6L40_09640	COG3021	interspecies interaction between organisms
I6L40_09645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L40_09650	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L40_09655	COG1061	Type III restriction enzyme res subunit
I6L40_09660	COG1566	PFAM secretion protein HlyD family protein
I6L40_09670	COG1966	Carbon starvation protein
I6L40_09675	COG3279	Response regulator of the LytR AlgR family
I6L40_09680	COG3275	phosphorelay sensor kinase activity
I6L40_09685	COG2199	diguanylate cyclase activity
I6L40_09685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L40_09695	COG1846	Transcriptional regulator
I6L40_09695	COG1940	carbohydrate kinase activity
I6L40_09700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L40_09705	COG0363	glucosamine-6-phosphate deaminase activity
I6L40_09710	COG1263	PTS System
I6L40_09710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_09710	COG2190	(PTS) system
I6L40_09720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L40_09725	COG0735	belongs to the Fur family
I6L40_09735	COG0716	FMN binding
I6L40_09750	COG0596	Alpha beta hydrolase
I6L40_09755	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L40_09760	COG0033	Phosphoglucomutase
I6L40_09765	COG2951	lytic endotransglycosylase activity
I6L40_09770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L40_09775	COG4136	ATPase activity
I6L40_09780	COG4135	transport system, permease component
I6L40_09785	COG4134	Bacterial extracellular solute-binding protein
I6L40_09795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L40_09805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L40_09815	COG0729	surface antigen
I6L40_09820	COG2911	Protein conserved in bacteria
I6L40_09840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L40_09850	COG0741	lytic transglycosylase activity
I6L40_09860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L40_09865	COG4771	TonB-dependent receptor
I6L40_09870	COG1169	isochorismate synthase
I6L40_09875	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L40_09880	COG1535	isochorismatase
I6L40_09880	COG3433	isochorismatase activity
I6L40_09885	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_09890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L40_09890	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L40_09915	COG1278	Cold shock
I6L40_09945	COG0697	spore germination
I6L40_09950	COG1349	DNA-binding transcription factor activity
I6L40_09955	COG1882	Formate acetyltransferase
I6L40_09960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L40_09965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L40_09990	COG4166	transmembrane transport
I6L40_09995	COG0622	Phosphoesterase
I6L40_10010	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L40_10015	COG0835	chemotaxis
I6L40_10015	COG0784	Response regulator, receiver
I6L40_10020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L40_10025	COG1815	bacterial-type flagellum-dependent cell motility
I6L40_10035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6L40_10045	COG4787	bacterial-type flagellum-dependent cell motility
I6L40_10055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L40_10060	COG1706	bacterial-type flagellum-dependent cell motility
I6L40_10065	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L40_10065	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6L40_10080	COG2239	Acts as a magnesium transporter
I6L40_10090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L40_10095	COG2716	regulation of RNA biosynthetic process
I6L40_10120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L40_10125	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L40_10130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L40_10135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L40_10155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L40_10175	COG0590	tRNA wobble adenosine to inosine editing
I6L40_10180	COG0573	inorganic phosphate transmembrane transporter activity
I6L40_10185	COG0581	inorganic phosphate transmembrane transporter activity
I6L40_10190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L40_10195	COG0704	Plays a role in the regulation of phosphate uptake
I6L40_10200	COG1253	flavin adenine dinucleotide binding
I6L40_10210	COG0646	methionine synthase
I6L40_10210	COG1410	methionine synthase
I6L40_10215	COG0531	amino acid
I6L40_10235	COG0765	amino acid transport
I6L40_10240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_10260	COG2197	response regulator
I6L40_10265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L40_10290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L40_10295	COG0477	Major facilitator Superfamily
I6L40_10300	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L40_10315	COG1199	ATP-dependent helicase activity
I6L40_10325	COG0287	Prephenate dehydrogenase
I6L40_10325	COG1605	Chorismate mutase
I6L40_10330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L40_10340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L40_10345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L40_10380	COG0537	adenosine 5'-monophosphoramidase activity
I6L40_10395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L40_10410	COG1301	dicarboxylic acid transport
I6L40_10420	COG2354	Protein conserved in bacteria
I6L40_10425	COG1164	Oligoendopeptidase f
I6L40_10430	COG2233	PERMEase
I6L40_10435	COG3150	esterase
I6L40_10440	COG1252	NADH dehydrogenase
I6L40_10450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L40_10455	COG3300	MHYT domain
I6L40_10455	COG5001	Diguanylate cyclase
I6L40_10460	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L40_10470	COG2373	Large extracellular alpha-helical protein
I6L40_10475	COG4953	penicillin-binding protein 1C
I6L40_10490	COG0301	tRNA thio-modification
I6L40_10490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L40_10550	COG2089	acid synthase
I6L40_10565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L40_10570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L40_10575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L40_10585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L40_10590	COG1086	Polysaccharide biosynthesis protein
I6L40_10595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L40_10605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L40_10620	COG0483	inositol monophosphate 1-phosphatase activity
I6L40_10630	COG0625	glutathione transferase activity
I6L40_10635	COG2814	Major facilitator Superfamily
I6L40_10640	COG0583	DNA-binding transcription factor activity
I6L40_10645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L40_10650	COG0243	molybdopterin cofactor binding
I6L40_10670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L40_10675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L40_10680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L40_10685	COG0509	glycine decarboxylation via glycine cleavage system
I6L40_10690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L40_10690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L40_10695	COG0840	transmembrane signaling receptor activity
I6L40_10700	COG0546	phosphoglycolate phosphatase activity
I6L40_10725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L40_10730	COG0574	Belongs to the PEP-utilizing enzyme family
I6L40_10730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L40_10745	COG1464	Belongs to the NlpA lipoprotein family
I6L40_10750	COG3083	sulfuric ester hydrolase activity
I6L40_10755	COG3082	Protein of unknown function (DUF1414)
I6L40_10760	COG3081	Nucleoid-associated protein
I6L40_10770	COG1175	transmembrane transport
I6L40_10775	COG3833	ABC-type maltose transport systems, permease component
I6L40_10780	COG3842	ATPase activity
I6L40_10805	COG0425	Belongs to the sulfur carrier protein TusA family
I6L40_10810	COG4783	chaperone-mediated protein folding
I6L40_10820	COG1393	Belongs to the ArsC family
I6L40_10835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L40_10840	COG2431	L-lysine efflux transmembrane transporter activity
I6L40_10860	COG4160	amino acid transport
I6L40_10865	COG0564	pseudouridine synthase activity
I6L40_10880	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L40_10890	COG0625	glutathione transferase activity
I6L40_10900	COG0367	asparagine synthase
I6L40_10910	COG4651	solute:proton antiporter activity
I6L40_10910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L40_10915	COG0647	UMP catabolic process
I6L40_10930	COG1902	pentaerythritol trinitrate reductase activity
I6L40_10935	COG1253	flavin adenine dinucleotide binding
I6L40_10945	COG0277	FAD linked oxidase domain protein
I6L40_10945	COG0247	lactate metabolic process
I6L40_10955	COG2050	protein possibly involved in aromatic compounds catabolism
I6L40_10970	COG3300	MHYT domain
I6L40_10970	COG5001	Diguanylate cyclase
I6L40_10975	COG2056	Na+-H+ antiporter family
I6L40_10980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L40_10985	COG0671	phosphoesterase, PA-phosphatase related
I6L40_10990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L40_10995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L40_11005	COG0101	tRNA pseudouridine synthase activity
I6L40_11010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L40_11015	COG0285	dihydrofolate synthase activity
I6L40_11020	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L40_11025	COG0393	Putative heavy-metal-binding
I6L40_11035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L40_11035	COG1648	precorrin-2 dehydrogenase activity
I6L40_11055	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L40_11060	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L40_11065	COG1368	sulfuric ester hydrolase activity
I6L40_11075	COG0527	aspartate kinase activity
I6L40_11080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L40_11080	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L40_11085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L40_11105	COG0596	Alpha beta hydrolase
I6L40_11110	COG0840	transmembrane signaling receptor activity
I6L40_11125	COG2814	Major facilitator Superfamily
I6L40_11140	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
I6L40_11145	COG0672	)-iron permease
I6L40_11175	COG0659	secondary active sulfate transmembrane transporter activity
I6L40_11250	COG3829	transcription factor binding
I6L40_11285	COG4104	PAAR repeat-containing protein
I6L40_11300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L40_11305	COG0326	Molecular chaperone. Has ATPase activity
I6L40_11310	COG4172	Belongs to the ABC transporter superfamily
I6L40_11335	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L40_11340	COG1842	Phage shock protein A
I6L40_11355	COG3106	COG3106 Predicted ATPase
I6L40_11360	COG3768	UPF0283 membrane protein
I6L40_11370	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L40_11395	COG2199	diguanylate cyclase activity
I6L40_11400	COG2885	chlorophyll binding
I6L40_11405	COG0861	Integral membrane protein TerC family
I6L40_11420	COG1022	Amp-dependent synthetase and ligase
I6L40_11435	COG2910	NAD(P)H-binding
I6L40_11440	COG0583	DNA-binding transcription factor activity
I6L40_11445	COG2271	Major facilitator Superfamily
I6L40_11455	COG1335	isochorismatase
I6L40_11465	COG0583	DNA-binding transcription factor activity
I6L40_11470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L40_11485	COG0583	DNA-binding transcription factor activity
I6L40_11490	COG2723	6-phospho-beta-galactosidase activity
I6L40_11495	COG1944	ATP diphosphatase activity
I6L40_11500	COG2116	formate transmembrane transporter activity
I6L40_11505	COG1882	Formate acetyltransferase
I6L40_11515	COG2983	Belongs to the UPF0260 family
I6L40_11530	COG0058	SHG alpha-glucan phosphorylase activity
I6L40_11535	COG0471	metal ion transport
I6L40_11540	COG3118	belongs to the thioredoxin family
I6L40_11545	COG4999	Histidine kinase
I6L40_11545	COG2205	protein histidine kinase activity
I6L40_11545	COG3437	response regulator, receiver
I6L40_11545	COG3850	Histidine kinase
I6L40_11550	COG1132	(ABC) transporter
I6L40_11555	COG1132	(ABC) transporter
I6L40_11565	COG2501	S4 domain
I6L40_11580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L40_11635	COG2009	succinate dehydrogenase
I6L40_11640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L40_11645	COG1053	succinate dehydrogenase
I6L40_11655	COG0567	Dehydrogenase, E1 component
I6L40_11660	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L40_11665	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L40_11695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_11705	COG3842	ATPase activity
I6L40_11710	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L40_11720	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L40_11730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L40_11735	COG4235	cytochrome complex assembly
I6L40_11735	COG3088	subunit of a heme lyase
I6L40_11745	COG1138	Cytochrome C-type biogenesis protein
I6L40_11750	COG3301	Polysulphide reductase, NrfD
I6L40_11755	COG0437	4 iron, 4 sulfur cluster binding
I6L40_11760	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L40_11775	COG0247	lactate metabolic process
I6L40_11780	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L40_11785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L40_11800	COG0840	transmembrane signaling receptor activity
I6L40_11805	COG1940	carbohydrate kinase activity
I6L40_11805	COG1846	Transcriptional regulator
I6L40_11810	COG3148	PFAM DTW domain containing protein
I6L40_11815	COG0730	response to heat
I6L40_11820	COG0583	DNA-binding transcription factor activity
I6L40_11835	COG3593	DNA synthesis involved in DNA repair
I6L40_11885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L40_11890	COG1011	Hydrolase
I6L40_11905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L40_11910	COG2832	Protein of unknown function (DUF454)
I6L40_11915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L40_11925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L40_11950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L40_11955	COG0583	DNA-binding transcription factor activity
I6L40_11965	COG1560	Kdo2-lipid A biosynthetic process
I6L40_11970	COG1560	Kdo2-lipid A biosynthetic process
I6L40_11990	COG0417	DNA replication proofreading
I6L40_12005	COG1451	nucleotide metabolic process
I6L40_12020	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L40_12035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_12035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L40_12040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L40_12050	COG0569	domain protein
I6L40_12050	COG2985	domain, Protein
I6L40_12060	COG0556	nucleotide-excision repair
I6L40_12070	COG0586	Pfam SNARE associated Golgi protein
I6L40_12075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L40_12080	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L40_12105	COG3829	transcription factor binding
I6L40_12135	COG0534	Mate efflux family protein
I6L40_12150	COG0307	riboflavin synthase, alpha
I6L40_12165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L40_12170	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L40_12175	COG0697	spore germination
I6L40_12180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L40_12220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L40_12225	COG3099	Belongs to the UPF0263 family
I6L40_12230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L40_12235	COG2894	cell division
I6L40_12240	COG0850	regulation of cytokinetic process
I6L40_12245	COG3100	YcgL domain-containing protein
I6L40_12250	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L40_12265	COG3791	Glutathione-dependent formaldehyde-activating
I6L40_12275	COG3706	GGDEF domain
I6L40_12280	COG2840	Smr protein MutS2
I6L40_12285	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L40_12290	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L40_12300	COG0513	Belongs to the DEAD box helicase family
I6L40_12305	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L40_12320	COG0814	amino acid
I6L40_12325	COG1609	Transcriptional regulator
I6L40_12330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_12330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_12335	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L40_12340	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L40_12340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_12340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_12345	COG2140	Oxalate decarboxylase
I6L40_12350	COG1609	Transcriptional regulator
I6L40_12365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_12365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_12370	COG3715	PTS system
I6L40_12375	COG3716	PTS system mannose fructose sorbose family IID component
I6L40_12380	COG2942	2-epimerase
I6L40_12385	COG3313	Fe-S protein
I6L40_12390	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L40_12395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L40_12400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L40_12405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L40_12415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L40_12425	COG0366	Alpha amylase catalytic
I6L40_12445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L40_12450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L40_12455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L40_12460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L40_12465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L40_12470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L40_12475	COG0072	phenylalanine-tRNA ligase activity
I6L40_12475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L40_12480	COG0776	regulation of translation
I6L40_12485	COG0784	Response regulator, receiver
I6L40_12485	COG2205	protein histidine kinase activity
I6L40_12505	COG1609	Transcriptional regulator
I6L40_12510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L40_12515	COG1879	ABC-type sugar transport system periplasmic component
I6L40_12520	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L40_12525	COG1129	ABC transporter
I6L40_12530	COG1869	D-ribose catabolic process
I6L40_12535	COG0625	glutathione transferase activity
I6L40_12550	COG1177	transmembrane transport
I6L40_12575	COG0037	tRNA processing
I6L40_12580	COG0589	response to stress
I6L40_12585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L40_12610	COG2010	Cytochrome c
I6L40_12625	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L40_12640	COG1956	GAF domain-containing protein
I6L40_12645	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L40_12655	COG0308	aminopeptidase N
I6L40_12665	COG2902	Dehydrogenase
I6L40_12670	COG0167	dihydroorotate dehydrogenase activity
I6L40_12685	COG5001	Diguanylate cyclase
I6L40_12685	COG2203	Gaf domain
I6L40_12685	COG3706	GGDEF domain
I6L40_12685	COG4251	negative regulation of phosphorylation
I6L40_12690	COG2201	protein-glutamate methylesterase activity
I6L40_12700	COG0835	chemotaxis
I6L40_12705	COG3290	protein histidine kinase activity
I6L40_12705	COG0840	transmembrane signaling receptor activity
I6L40_12725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L40_12725	COG0116	Belongs to the methyltransferase superfamily
I6L40_12735	COG0488	(ABC) transporter
I6L40_12745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L40_12750	COG1067	ATP-dependent peptidase activity
I6L40_12770	COG3141	response to X-ray
I6L40_12780	COG4221	oxidoreductase activity
I6L40_12805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L40_12825	COG0372	Belongs to the citrate synthase family
I6L40_12830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L40_12840	COG2995	paraquat-inducible protein a
I6L40_12845	COG3008	intermembrane lipid transfer
I6L40_12850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L40_12850	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L40_12865	COG0084	hydrolase, TatD family'
I6L40_12870	COG0470	DNA polymerase III
I6L40_12875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L40_12880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L40_12885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L40_12895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L40_12900	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_12910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L40_12915	COG0416	fatty acid biosynthetic process
I6L40_12920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L40_12925	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L40_12930	COG0424	maF-like protein
I6L40_12945	COG1530	ribonuclease E activity
I6L40_12955	COG0306	phosphate transporter
I6L40_12960	COG0717	Belongs to the dCTP deaminase family
I6L40_12965	COG0572	uridine kinase
I6L40_12970	COG0489	protein tyrosine kinase activity
I6L40_12975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L40_12975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L40_12985	COG1254	Belongs to the acylphosphatase family
I6L40_12990	COG0840	transmembrane signaling receptor activity
I6L40_12995	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L40_13005	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L40_13010	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L40_13015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L40_13025	COG0318	PFAM AMP-dependent synthetase and ligase
I6L40_13030	COG2267	carboxylic ester hydrolase activity
I6L40_13040	COG1214	PFAM Peptidase M22, glycoprotease
I6L40_13045	COG1199	ATP-dependent helicase activity
I6L40_13055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L40_13060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L40_13065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L40_13070	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L40_13070	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L40_13075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L40_13080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L40_13085	COG0107	imidazoleglycerol-phosphate synthase activity
I6L40_13100	COG2199	diguanylate cyclase activity
I6L40_13105	COG0318	PFAM AMP-dependent synthetase and ligase
I6L40_13110	COG1288	antiporter activity
I6L40_13120	COG3134	Outer membrane lipoprotein
I6L40_13125	COG2080	2 iron, 2 sulfur cluster binding
I6L40_13130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L40_13135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L40_13140	COG2252	PERMEase
I6L40_13145	COG0402	S-adenosylhomocysteine deaminase activity
I6L40_13150	COG2233	PERMEase
I6L40_13155	COG2080	2 iron, 2 sulfur cluster binding
I6L40_13155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L40_13160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L40_13165	COG0402	S-adenosylhomocysteine deaminase activity
I6L40_13170	COG0493	'glutamate synthase
I6L40_13170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L40_13180	COG2068	MobA-Related Protein
I6L40_13185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L40_13190	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L40_13190	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L40_13195	COG0697	spore germination
I6L40_13200	COG0549	Belongs to the carbamate kinase family
I6L40_13210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L40_13215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L40_13220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L40_13245	COG0242	peptide deformylase activity
I6L40_13255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L40_13260	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L40_13265	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L40_13275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L40_13280	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L40_13290	COG0205	6-phosphofructokinase activity
I6L40_13295	COG1301	dicarboxylic acid transport
I6L40_13300	COG3123	guanosine phosphorylase activity
I6L40_13305	COG1760	l-serine dehydratase
I6L40_13310	COG1760	l-serine dehydratase
I6L40_13330	COG0814	amino acid
I6L40_13335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L40_13340	COG0514	ATP-dependent DNA helicase (RecQ)
I6L40_13345	COG2766	serine protein kinase
I6L40_13350	COG2718	Belongs to the UPF0229 family
I6L40_13355	COG2719	SpoVR family
I6L40_13360	COG1024	Enoyl-CoA hydratase
I6L40_13360	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L40_13365	COG0183	Belongs to the thiolase family
I6L40_13370	COG0714	Associated with various cellular activities
I6L40_13400	COG1595	DNA-templated transcription, initiation
I6L40_13410	COG2067	long-chain fatty acid transport protein
I6L40_13415	COG2067	long-chain fatty acid transport protein
I6L40_13420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L40_13435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L40_13445	COG1643	Atp-dependent helicase
I6L40_13450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L40_13450	COG0617	tRNA 3'-terminal CCA addition
I6L40_13450	COG0517	IMP dehydrogenase activity
I6L40_13455	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L40_13460	COG2925	Exonuclease
I6L40_13470	COG3345	alpha-galactosidase
I6L40_13475	COG1380	Effector of murein hydrolase LrgA
I6L40_13480	COG1346	cytolysis
I6L40_13485	COG0295	cytidine deaminase activity
I6L40_13490	COG3033	Beta-eliminating lyase
I6L40_13500	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L40_13505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_13515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L40_13540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L40_13550	COG0454	-acetyltransferase
I6L40_13555	COG3158	transport of potassium into the cell
I6L40_13560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L40_13565	COG0651	ATP synthesis coupled electron transport
I6L40_13570	COG0650	Formate hydrogenlyase subunit 4
I6L40_13575	COG3261	NADH dehydrogenase
I6L40_13575	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L40_13580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_13585	COG3260	NADH ubiquinone oxidoreductase 20
I6L40_13595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L40_13605	COG1921	L-seryl-tRNASec selenium transferase activity
I6L40_13615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L40_13620	COG0298	carbon dioxide binding
I6L40_13630	COG0309	Hydrogenase expression formation protein (HypE)
I6L40_13635	COG0375	protein maturation
I6L40_13640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L40_13645	COG1124	(ABC) transporter
I6L40_13655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L40_13670	COG1773	rubredoxin
I6L40_13675	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L40_13680	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L40_13685	COG5557	Pfam Polysulphide reductase, NrfD
I6L40_13690	COG0437	4 iron, 4 sulfur cluster binding
I6L40_13695	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L40_13720	COG0730	response to heat
I6L40_13730	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_13740	COG1024	Enoyl-CoA hydratase
I6L40_13745	COG1024	Enoyl-CoA hydratase
I6L40_13750	COG1960	acyl-CoA dehydrogenase activity
I6L40_13755	COG1960	acyl-CoA dehydrogenase activity
I6L40_13760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L40_13765	COG1024	Enoyl-CoA hydratase
I6L40_13795	COG1584	GPR1 FUN34 yaaH family protein
I6L40_13800	COG3228	Belongs to the MtfA family
I6L40_13810	COG1115	amino acid carrier protein
I6L40_13815	COG1024	Enoyl-CoA hydratase
I6L40_13830	COG3162	membrane
I6L40_13835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L40_13840	COG0488	(ABC) transporter
I6L40_13845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L40_13850	COG0776	regulation of translation
I6L40_13855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L40_13860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L40_13865	COG0740	serine-type endopeptidase activity
I6L40_13870	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L40_13880	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L40_13885	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L40_13890	COG1136	(ABC) transporter
I6L40_13895	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L40_13905	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L40_13910	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L40_13915	COG4166	transmembrane transport
I6L40_13920	COG0697	spore germination
I6L40_13930	COG2062	phosphohistidine phosphatase, SixA
I6L40_13980	COG0519	Catalyzes the synthesis of GMP from XMP
I6L40_13980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L40_13985	COG0516	GMP reductase activity
I6L40_13985	COG0517	IMP dehydrogenase activity
I6L40_13995	COG1570	exodeoxyribonuclease VII activity
I6L40_14000	COG2188	Transcriptional regulator
I6L40_14005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_14005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_14005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_14010	COG0383	alpha-mannosidase activity
I6L40_14015	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L40_14025	COG0386	Belongs to the glutathione peroxidase family
I6L40_14030	COG0513	Belongs to the DEAD box helicase family
I6L40_14045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L40_14050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L40_14105	COG5001	Diguanylate cyclase
I6L40_14105	COG3300	MHYT domain
I6L40_14120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L40_14130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L40_14135	COG0563	adenylate kinase activity
I6L40_14145	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L40_14150	COG1286	toxin biosynthetic process
I6L40_14155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L40_14160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L40_14165	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L40_14170	COG1674	ftsk spoiiie
I6L40_14170	COG0531	amino acid
I6L40_14180	COG0686	Belongs to the AlaDH PNT family
I6L40_14185	COG0492	ferredoxin-NADP+ reductase activity
I6L40_14190	COG3706	GGDEF domain
I6L40_14195	COG3134	Outer membrane lipoprotein
I6L40_14200	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L40_14205	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L40_14210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L40_14215	COG0542	response to heat
I6L40_14220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L40_14225	COG1278	Cold shock
I6L40_14230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L40_14250	COG0745	RESPONSE REGULATOR receiver
I6L40_14255	COG2205	protein histidine kinase activity
I6L40_14265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6L40_14265	COG0392	lysyltransferase activity
I6L40_14275	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L40_14305	COG1435	thymidine kinase activity
I6L40_14310	COG1757	Na H antiporter
I6L40_14315	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L40_14320	COG2096	Adenosyltransferase
I6L40_14325	COG3530	Putative quorum-sensing-regulated virulence factor
I6L40_14330	COG0602	queuosine metabolic process
I6L40_14335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L40_14355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L40_14365	COG0776	regulation of translation
I6L40_14370	COG0539	negative regulation of cytoplasmic translation
I6L40_14375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L40_14380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L40_14385	COG0583	DNA-binding transcription factor activity
I6L40_14395	COG2814	Major facilitator Superfamily
I6L40_14415	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L40_14420	COG5001	Diguanylate cyclase
I6L40_14420	COG3300	MHYT domain
I6L40_14425	COG0583	DNA-binding transcription factor activity
I6L40_14430	COG3437	response regulator, receiver
I6L40_14455	COG4989	oxidoreductase activity
I6L40_14460	COG0724	RNA recognition motif
I6L40_14470	COG1126	abc transporter atp-binding protein
I6L40_14475	COG0765	amino acid transport
I6L40_14480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_14485	COG4597	amino acid ABC transporter
I6L40_14490	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6L40_14500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L40_14515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L40_14520	COG1360	Flagellar Motor Protein
I6L40_14525	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_14530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_14535	COG0649	NAD binding
I6L40_14535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_14550	COG1034	ATP synthesis coupled electron transport
I6L40_14555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L40_14560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_14565	COG0839	Belongs to the complex I subunit 6 family
I6L40_14570	COG0713	ATP synthesis coupled electron transport
I6L40_14580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_14585	COG1007	ATP synthesis coupled electron transport
I6L40_14590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L40_14590	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L40_14595	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L40_14600	COG1645	bacterial-type flagellum-dependent swarming motility
I6L40_14605	COG1160	GTP binding
I6L40_14610	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L40_14615	COG2976	Protein conserved in bacteria
I6L40_14620	COG0124	histidyl-tRNA synthetase
I6L40_14640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L40_14645	COG0105	UTP biosynthetic process
I6L40_14650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L40_14660	COG0633	Ferredoxin
I6L40_14665	COG0443	Heat shock 70 kDa protein
I6L40_14670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L40_14680	COG0822	iron-sulfur transferase activity
I6L40_14685	COG1104	cysteine desulfurase activity
I6L40_14690	COG1959	2 iron, 2 sulfur cluster binding
I6L40_14705	COG3154	lipid carrier protein
I6L40_14710	COG0826	peptidase U32
I6L40_14715	COG0826	peptidase U32
I6L40_14730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L40_14735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L40_14740	COG1862	Preprotein translocase
I6L40_14745	COG0343	queuine tRNA-ribosyltransferase activity
I6L40_14750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L40_14755	COG0517	IMP dehydrogenase activity
I6L40_14755	COG1125	glycine betaine transport
I6L40_14770	COG3634	alkyl hydroperoxide reductase activity
I6L40_14835	COG1242	4 iron, 4 sulfur cluster binding
I6L40_14840	COG0067	glutamate synthase
I6L40_14840	COG0069	glutamate synthase activity
I6L40_14840	COG0070	glutamate synthase
I6L40_14845	COG0493	'glutamate synthase
I6L40_14850	COG1126	abc transporter atp-binding protein
I6L40_14855	COG0765	amino acid transport
I6L40_14860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_14875	COG0513	Belongs to the DEAD box helicase family
I6L40_14890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6L40_14900	COG0023	Translation Initiation Factor
I6L40_14905	COG2119	membrane
I6L40_14955	COG0215	cysteine-tRNA ligase activity
I6L40_14960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L40_14970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L40_14980	COG2261	transglycosylase associated protein
I6L40_14985	COG0642	Histidine kinase
I6L40_15020	COG4974	Belongs to the 'phage' integrase family
I6L40_15115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L40_15120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L40_15125	COG4695	Portal protein
I6L40_15305	COG0322	excinuclease ABC activity
I6L40_15310	COG2197	response regulator
I6L40_15315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L40_15320	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L40_15325	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L40_15335	COG0658	competence protein
I6L40_15335	COG2333	competence protein COMEC
I6L40_15350	COG1448	Aminotransferase
I6L40_15360	COG0583	DNA-binding transcription factor activity
I6L40_15365	COG3085	chromosome segregation
I6L40_15370	COG4574	serine-type endopeptidase inhibitor activity
I6L40_15375	COG0584	glycerophosphoryl diester phosphodiesterase
I6L40_15385	COG1349	DNA-binding transcription factor activity
I6L40_15390	COG2271	Major facilitator Superfamily
I6L40_15395	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L40_15400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L40_15405	COG0840	transmembrane signaling receptor activity
I6L40_15415	COG0583	DNA-binding transcription factor activity
I6L40_15435	COG0656	L-ascorbic acid biosynthetic process
I6L40_15440	COG2814	Major facilitator Superfamily
I6L40_15445	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L40_15460	COG3220	belongs to the UPF0276 family
I6L40_15480	COG1294	oxidase, subunit
I6L40_15490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L40_15495	COG2979	Protein of unknown function (DUF533)
I6L40_15520	COG2807	transmembrane transport
I6L40_15525	COG1187	pseudouridine synthase activity
I6L40_15530	COG0346	lactoylglutathione lyase activity
I6L40_15560	COG4657	Part of a membrane complex involved in electron transport
I6L40_15565	COG2878	Part of a membrane complex involved in electron transport
I6L40_15575	COG4658	electron transport chain
I6L40_15580	COG4659	FMN binding
I6L40_15585	COG4660	Part of a membrane complex involved in electron transport
I6L40_15590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L40_15595	COG0346	lactoylglutathione lyase activity
I6L40_15610	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6L40_15640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L40_15645	COG0505	Belongs to the CarA family
I6L40_15650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L40_15660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L40_15665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L40_15670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L40_15675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L40_15680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L40_15685	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L40_15710	COG2020	methyltransferase activity
I6L40_15715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L40_15720	COG0861	Integral membrane protein TerC family
I6L40_15735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L40_15740	COG0601	transmembrane transport
I6L40_15750	COG2095	MarC family integral membrane protein
I6L40_15755	COG1012	belongs to the aldehyde dehydrogenase family
I6L40_15755	COG1454	alcohol dehydrogenase
I6L40_15760	COG0217	transcriptional regulatory protein
I6L40_15765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L40_15775	COG1801	Protein of unknown function DUF72
I6L40_15780	COG4106	trans-aconitate 2-methyltransferase activity
I6L40_15785	COG0500	methyltransferase
I6L40_15805	COG0450	alkyl hydroperoxide reductase
I6L40_15810	COG0583	DNA-binding transcription factor activity
I6L40_15815	COG0791	NLP P60 protein
I6L40_15825	COG0583	DNA-binding transcription factor activity
I6L40_15830	COG2610	gluconate transmembrane transporter activity
I6L40_15835	COG3048	D-serine ammonia-lyase activity
I6L40_15840	COG0538	isocitrate dehydrogenase activity
I6L40_15845	COG2207	Transcriptional regulator
I6L40_15850	COG1482	cell wall glycoprotein biosynthetic process
I6L40_15860	COG0840	transmembrane signaling receptor activity
I6L40_15870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_15885	COG3152	Membrane
I6L40_15890	COG2814	Major facilitator Superfamily
I6L40_15895	COG0109	protoheme IX farnesyltransferase activity
I6L40_15900	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6L40_15905	COG1845	cytochrome c oxidase, subunit III
I6L40_15910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6L40_15915	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6L40_15950	COG1309	transcriptional regulator
I6L40_15960	COG1454	alcohol dehydrogenase
I6L40_15980	COG0534	Mate efflux family protein
I6L40_15990	COG2841	Protein conserved in bacteria
I6L40_15995	COG3132	Protein of unknown function, DUF480
I6L40_16025	COG0708	Exodeoxyribonuclease III
I6L40_16050	COG1122	ATPase activity
I6L40_16070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_16075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_16085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L40_16090	COG1120	ATPase activity
I6L40_16095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L40_16100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L40_16105	COG2375	cellular response to nickel ion
I6L40_16110	COG0784	Response regulator, receiver
I6L40_16110	COG3437	response regulator, receiver
I6L40_16120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L40_16125	COG0328	RNA-DNA hybrid ribonuclease activity
I6L40_16130	COG2226	methyltransferase
I6L40_16135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L40_16140	COG1388	LysM domain
I6L40_16140	COG0741	lytic transglycosylase activity
I6L40_16165	COG5000	phosphorelay sensor kinase activity
I6L40_16165	COG5002	protein histidine kinase activity
I6L40_16170	COG0745	RESPONSE REGULATOR receiver
I6L40_16175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L40_16180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L40_16190	COG1376	ErfK ybiS ycfS ynhG family protein
I6L40_16190	COG1388	LysM domain
I6L40_16200	COG0471	metal ion transport
I6L40_16210	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L40_16215	COG0791	NLP P60 protein
I6L40_16225	COG3118	belongs to the thioredoxin family
I6L40_16235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L40_16240	COG0788	formyltetrahydrofolate deformylase activity
I6L40_16265	COG0739	heme binding
I6L40_16265	COG0741	lytic transglycosylase activity
I6L40_16265	COG1196	nuclear chromosome segregation
I6L40_16270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L40_16280	COG0436	Aminotransferase
I6L40_16285	COG1288	antiporter activity
I6L40_16290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L40_16295	COG1879	ABC-type sugar transport system periplasmic component
I6L40_16305	COG0406	alpha-ribazole phosphatase activity
I6L40_16310	COG2964	Protein conserved in bacteria
I6L40_16315	COG3681	Belongs to the UPF0597 family
I6L40_16325	COG0814	amino acid
I6L40_16345	COG1166	arginine decarboxylase activity
I6L40_16350	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L40_16380	COG0583	DNA-binding transcription factor activity
I6L40_16390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L40_16395	COG0840	transmembrane signaling receptor activity
I6L40_16400	COG0302	gtp cyclohydrolase
I6L40_16405	COG0303	'Molybdopterin
I6L40_16410	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L40_16430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L40_16445	COG0314	molybdopterin synthase activity
I6L40_16450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L40_16455	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L40_16460	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L40_16465	COG3005	denitrification pathway
I6L40_16475	COG0348	domain, Protein
I6L40_16480	COG0437	4 iron, 4 sulfur cluster binding
I6L40_16485	COG0243	molybdopterin cofactor binding
I6L40_16495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L40_16500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L40_16505	COG3850	Histidine kinase
I6L40_16510	COG2197	response regulator
I6L40_16540	COG0121	glutamine amidotransferase
I6L40_16545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L40_16550	COG1960	acyl-CoA dehydrogenase activity
I6L40_16555	COG1473	amidohydrolase
I6L40_16560	COG2914	Belongs to the UPF0125 (RnfH) family
I6L40_16565	COG2867	negative regulation of translational initiation
I6L40_16570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L40_16585	COG2814	Major facilitator Superfamily
I6L40_16585	COG0477	Major facilitator Superfamily
I6L40_16590	COG0457	Tetratricopeptide repeat
I6L40_16595	COG1940	carbohydrate kinase activity
I6L40_16600	COG3383	formate dehydrogenase (NAD+) activity
I6L40_16610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L40_16620	COG1960	acyl-CoA dehydrogenase activity
I6L40_16625	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L40_16640	COG1317	bacterial-type flagellum organization
I6L40_16730	COG0457	Tetratricopeptide repeat
I6L40_16800	COG4790	Type iii secretion
I6L40_16805	COG4794	Type iii secretion
I6L40_16810	COG4791	protein targeting
I6L40_16815	COG4792	protein secretion
I6L40_16830	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L40_16835	COG1263	PTS System
I6L40_16835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_16840	COG1609	Transcriptional regulator
I6L40_16860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_16860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_16860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_16870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L40_16880	COG1187	pseudouridine synthase activity
I6L40_16885	COG1051	belongs to the nudix hydrolase family
I6L40_16890	COG0482	sulfurtransferase activity
I6L40_16895	COG2915	High frequency lysogenization protein hflD homolog
I6L40_16900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L40_16905	COG2850	peptidyl-arginine hydroxylation
I6L40_16920	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6L40_16935	COG1397	ADP-ribosylglycohydrolase
I6L40_16945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L40_16965	COG0625	glutathione transferase activity
I6L40_16970	COG0259	pyridoxamine-phosphate oxidase activity
I6L40_16985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L40_16985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L40_16995	COG1882	Formate acetyltransferase
I6L40_17000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L40_17010	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L40_17015	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L40_17040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L40_17045	COG1138	Cytochrome C-type biogenesis protein
I6L40_17050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L40_17055	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L40_17060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L40_17065	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L40_17080	COG0835	chemotaxis
I6L40_17090	COG1192	Involved in chromosome partitioning
I6L40_17095	COG1360	Flagellar Motor Protein
I6L40_17100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L40_17105	COG2201	protein-glutamate methylesterase activity
I6L40_17110	COG0643	Histidine kinase
I6L40_17110	COG0784	Response regulator, receiver
I6L40_17110	COG2198	Histidine kinase
I6L40_17115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L40_17140	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L40_17150	COG1684	flagellar biosynthetic protein fliR
I6L40_17205	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L40_17215	COG1677	Flagellar hook-basal body complex protein FliE
I6L40_17225	COG0469	pyruvate kinase activity
I6L40_17230	COG1737	Transcriptional regulator
I6L40_17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L40_17270	COG2233	PERMEase
I6L40_17290	COG0745	RESPONSE REGULATOR receiver
I6L40_17300	COG0437	4 iron, 4 sulfur cluster binding
I6L40_17305	COG3383	formate dehydrogenase (NAD+) activity
I6L40_17305	COG3383	formate dehydrogenase (NAD+) activity
I6L40_17340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L40_17350	COG3852	Histidine kinase
I6L40_17355	COG2204	response regulator
I6L40_17365	COG4662	Binding-protein-dependent transport system inner membrane component
I6L40_17375	COG0746	molybdenum cofactor guanylyltransferase activity
I6L40_17380	COG0303	'Molybdopterin
I6L40_17385	COG1289	transmembrane transporter activity
I6L40_17390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L40_17430	COG2205	protein histidine kinase activity
I6L40_17430	COG0784	Response regulator, receiver
I6L40_17435	COG4166	transmembrane transport
I6L40_17440	COG0601	transmembrane transport
I6L40_17445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L40_17450	COG0444	Belongs to the ABC transporter superfamily
I6L40_17455	COG4608	Belongs to the ABC transporter superfamily
I6L40_17465	COG2971	BadF BadG BcrA BcrD
I6L40_17490	COG3724	N-succinylarginine dihydrolase activity
I6L40_17515	COG0784	Response regulator, receiver
I6L40_17515	COG2205	protein histidine kinase activity
I6L40_17515	COG5002	protein histidine kinase activity
I6L40_17520	COG2197	response regulator
I6L40_17545	COG2199	diguanylate cyclase activity
I6L40_17545	COG2200	EAL domain
I6L40_17545	COG2203	Gaf domain
I6L40_17550	COG0826	peptidase U32
I6L40_17555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L40_17565	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L40_17570	COG3706	GGDEF domain
I6L40_17575	COG2211	Major facilitator Superfamily
I6L40_17580	COG0616	signal peptide processing
I6L40_17585	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_17590	COG0583	DNA-binding transcription factor activity
I6L40_17600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L40_17615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L40_17620	COG1881	PFAM PEBP family protein
I6L40_17630	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L40_17630	COG3408	Glycogen debranching enzyme
I6L40_17640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L40_17655	COG1301	dicarboxylic acid transport
I6L40_17660	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L40_17665	COG2912	Transglutaminase-like superfamily
I6L40_17675	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L40_17680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L40_17685	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L40_17690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L40_17695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L40_17705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L40_17710	COG0737	Belongs to the 5'-nucleotidase family
I6L40_17715	COG0193	aminoacyl-tRNA hydrolase activity
I6L40_17720	COG0012	GTP binding
I6L40_17725	COG1012	belongs to the aldehyde dehydrogenase family
I6L40_17730	COG1177	transmembrane transport
I6L40_17735	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L40_17740	COG3842	ATPase activity
I6L40_17745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L40_17750	COG0583	DNA-binding transcription factor activity
I6L40_17795	COG0471	metal ion transport
I6L40_17795	COG0490	domain, Protein
I6L40_17805	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L40_17825	COG0366	Alpha amylase catalytic
I6L40_17830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L40_17830	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L40_17830	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L40_17830	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L40_17840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L40_17855	COG1012	belongs to the aldehyde dehydrogenase family
I6L40_17865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L40_17870	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L40_17880	COG0180	Tryptophanyl-tRNA synthetase
I6L40_17890	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L40_17895	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L40_17905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L40_17910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L40_17940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L40_17945	COG0583	DNA-binding transcription factor activity
I6L40_17965	COG0583	DNA-binding transcription factor activity
I6L40_17975	COG0739	heme binding
I6L40_17985	COG1511	domain protein
I6L40_17985	COG3264	Mechanosensitive ion channel
I6L40_17990	COG0584	glycerophosphoryl diester phosphodiesterase
I6L40_18000	COG1053	succinate dehydrogenase
I6L40_18005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L40_18010	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L40_18015	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L40_18020	COG3366	ferrous iron transmembrane transporter activity
I6L40_18025	COG0700	Nucleoside recognition
I6L40_18030	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L40_18040	COG3214	Protein conserved in bacteria
I6L40_18055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_18070	COG0318	PFAM AMP-dependent synthetase and ligase
I6L40_18080	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_18105	COG0516	GMP reductase activity
I6L40_18115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L40_18125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L40_18135	COG0583	DNA-binding transcription factor activity
I6L40_18140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6L40_18150	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L40_18175	COG3706	GGDEF domain
I6L40_18185	COG1335	isochorismatase
I6L40_18190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L40_18195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L40_18200	COG1702	phosphate starvation-inducible protein PhoH
I6L40_18205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L40_18210	COG4535	Mg2 and Co2 transporter CorC
I6L40_18215	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L40_18230	COG1970	mechanosensitive ion channel activity
I6L40_18235	COG4974	Belongs to the 'phage' integrase family
I6L40_18240	COG0716	FMN binding
I6L40_18250	COG0312	modulator of DNA gyrase
I6L40_18255	COG2888	peptidyl-tyrosine sulfation
I6L40_18260	COG0495	leucyl-tRNA aminoacylation
I6L40_18275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L40_18280	COG0799	negative regulation of ribosome biogenesis
I6L40_18285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L40_18290	COG0768	penicillin binding
I6L40_18295	COG0772	Belongs to the SEDS family
I6L40_18300	COG2951	lytic endotransglycosylase activity
I6L40_18305	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L40_18310	COG1686	Belongs to the peptidase S11 family
I6L40_18315	COG2921	Belongs to the UPF0250 family
I6L40_18320	COG0321	lipoyl(octanoyl) transferase activity
I6L40_18325	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L40_18345	COG3139	Protein of unknown function (DUF1315)
I6L40_18350	COG0252	asparaginase activity
I6L40_18355	COG0786	glutamate:sodium symporter activity
I6L40_18370	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L40_18375	COG0384	phenazine biosynthesis protein PhzF
I6L40_18380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L40_18385	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L40_18390	COG0175	sulfate reduction
I6L40_18405	COG2966	Psort location CytoplasmicMembrane, score
I6L40_18415	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L40_18430	COG2897	thiosulfate sulfurtransferase activity
I6L40_18435	COG2066	Belongs to the glutaminase family
I6L40_18440	COG3171	Protein conserved in bacteria
I6L40_18445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L40_18450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L40_18455	COG2200	EAL domain
I6L40_18460	COG1090	epimerase
I6L40_18465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L40_18470	COG4181	ATPase activity
I6L40_18475	COG2755	lipolytic protein G-D-S-L family
I6L40_18480	COG0784	Response regulator, receiver
I6L40_18480	COG0835	chemotaxis
I6L40_18535	COG5002	protein histidine kinase activity
I6L40_18535	COG2205	protein histidine kinase activity
I6L40_18535	COG0784	Response regulator, receiver
I6L40_18545	COG3655	Transcriptional regulator
I6L40_18555	COG2814	Major facilitator Superfamily
I6L40_18565	COG3179	chitinase
I6L40_18570	COG3501	Rhs element vgr protein
I6L40_18580	COG2771	luxR family
I6L40_18605	COG0748	coenzyme F420 binding
I6L40_18610	COG3721	Heme iron utilization protein
I6L40_18620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L40_18635	COG3275	phosphorelay sensor kinase activity
I6L40_18640	COG3279	Response regulator of the LytR AlgR family
I6L40_18645	COG1966	Carbon starvation protein
I6L40_18660	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L40_18680	COG0737	Belongs to the 5'-nucleotidase family
I6L40_18700	COG2204	response regulator
I6L40_18705	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L40_18720	COG1047	Peptidyl-prolyl cis-trans
I6L40_18725	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L40_18735	COG0835	chemotaxis
I6L40_18735	COG0784	Response regulator, receiver
I6L40_18740	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L40_18750	COG3089	Belongs to the UPF0270 family
I6L40_18755	COG3954	Phosphoribulokinase
I6L40_18770	COG1765	OsmC-like protein
I6L40_18815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L40_18820	COG2313	pseudouridylate synthase activity
I6L40_18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L40_18870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L40_18880	COG2986	histidine ammonia-lyase
I6L40_18905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L40_18910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L40_18915	COG1028	Short-chain dehydrogenase reductase Sdr
I6L40_18920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L40_18940	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L40_18960	COG2985	domain, Protein
I6L40_18960	COG0569	domain protein
I6L40_18965	COG1272	protein, Hemolysin III
I6L40_18970	COG0076	glutamate decarboxylase activity
I6L40_18975	COG2917	probably involved in intracellular septation
I6L40_18980	COG2350	Protein conserved in bacteria
I6L40_18990	COG1349	DNA-binding transcription factor activity
I6L40_19000	COG2222	sugar isomerase
I6L40_19005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_19015	COG3716	PTS system mannose fructose sorbose family IID component
I6L40_19020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_19025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L40_19035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L40_19035	COG1263	PTS System
I6L40_19040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L40_19045	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L40_19050	COG1381	Involved in DNA repair and RecF pathway recombination
I6L40_19065	COG0681	Belongs to the peptidase S26 family
I6L40_19070	COG0481	GTPase activity
I6L40_19080	COG3026	antisigma factor binding
I6L40_19085	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L40_19090	COG1595	DNA-templated transcription, initiation
I6L40_19095	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L40_19110	COG0354	folic acid binding
I6L40_19155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L40_19165	COG0126	phosphoglycerate kinase activity
I6L40_19170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L40_19175	COG1940	carbohydrate kinase activity
I6L40_19180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L40_19185	COG2816	NAD+ diphosphatase activity
I6L40_19195	COG4991	sh3 domain protein
I6L40_19200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L40_19215	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L40_19250	COG2816	NAD+ diphosphatase activity
I6L40_19290	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L40_19300	COG2203	Gaf domain
I6L40_19300	COG2199	diguanylate cyclase activity
I6L40_19305	COG0513	Belongs to the DEAD box helicase family
I6L40_19315	COG0471	metal ion transport
I6L40_19335	COG2957	Belongs to the agmatine deiminase family
I6L40_19350	COG1902	pentaerythritol trinitrate reductase activity
I6L40_19360	COG1388	LysM domain
I6L40_19360	COG4942	peptidase
I6L40_19365	COG1238	metal cluster binding
I6L40_19370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L40_19375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L40_19380	COG0585	pseudouridine synthase activity
I6L40_19390	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L40_19395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L40_19400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L40_19410	COG1376	ErfK ybiS ycfS ynhG family protein
I6L40_19415	COG0668	transmembrane transport
I6L40_19425	COG2731	YhcH YjgK YiaL family protein
I6L40_19435	COG1794	racemase activity, acting on amino acids and derivatives
I6L40_19450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L40_19470	COG0488	(ABC) transporter
I6L40_19480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L40_19500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L40_19505	COG0148	phosphopyruvate hydratase activity
I6L40_19510	COG0504	CTP synthase activity
I6L40_19515	COG3956	TIGRFAM MazG family protein
I6L40_19520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L40_19525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L40_19535	COG4807	Protein conserved in bacteria
I6L40_19540	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L40_19545	COG0783	Belongs to the Dps family
I6L40_19550	COG1151	hydroxylamine reductase activity
I6L40_19555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L40_19560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L40_19565	COG0671	phosphoesterase, PA-phosphatase related
I6L40_19570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L40_19575	COG0163	prenyltransferase activity
I6L40_19590	COG1131	(ABC) transporter
I6L40_19595	COG0842	Transport permease protein
I6L40_19600	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6L40_19605	COG1924	4 iron, 4 sulfur cluster binding
I6L40_19625	COG1823	symporter activity
I6L40_19635	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L40_19640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L40_19645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L40_19655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L40_19660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L40_19665	COG1489	DNA binding
I6L40_19675	COG1643	Atp-dependent helicase
I6L40_19680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L40_19685	COG0346	lactoylglutathione lyase activity
I6L40_19690	COG2076	Multidrug Resistance protein
I6L40_19695	COG2076	Multidrug Resistance protein
I6L40_19705	COG3437	response regulator, receiver
I6L40_19705	COG0784	Response regulator, receiver
I6L40_19710	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L40_19725	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L40_19760	COG0840	transmembrane signaling receptor activity
I6L40_19770	COG0529	Catalyzes the synthesis of activated sulfate
I6L40_19775	COG2895	sulfate adenylyltransferase (ATP) activity
I6L40_19780	COG0175	sulfate reduction
I6L40_19785	COG1648	precorrin-2 dehydrogenase activity
I6L40_19785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L40_19790	COG0330	HflC and HflK could
I6L40_19795	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L40_19800	COG0840	transmembrane signaling receptor activity
I6L40_19805	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L40_19815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L40_19820	COG1640	4-alpha-glucanotransferase
I6L40_19825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L40_19845	COG1051	belongs to the nudix hydrolase family
I6L40_19870	COG0561	phosphatase activity
I6L40_19885	COG0733	neurotransmitter:sodium symporter activity
I6L40_19895	COG0733	neurotransmitter:sodium symporter activity
I6L40_19960	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L40_19965	COG2885	chlorophyll binding
I6L40_19970	COG0823	Involved in the tonB-independent uptake of proteins
I6L40_19985	COG0811	peptide transport
I6L40_19990	COG0824	Thioesterase
I6L40_19995	COG3790	cyd operon protein YbgE
I6L40_20000	COG4890	Cyd operon protein YbgT
I6L40_20005	COG1294	oxidase, subunit
I6L40_20015	COG2255	four-way junction helicase activity
I6L40_20020	COG0632	four-way junction helicase activity
I6L40_20025	COG0840	transmembrane signaling receptor activity
I6L40_20035	COG2771	luxR family
I6L40_20050	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L40_20055	COG5001	Diguanylate cyclase
I6L40_20055	COG4251	negative regulation of phosphorylation
I6L40_20055	COG3706	GGDEF domain
I6L40_20055	COG2203	Gaf domain
I6L40_20065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L40_20075	COG2995	paraquat-inducible protein a
I6L40_20080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L40_20080	COG3008	intermembrane lipid transfer
I6L40_20085	COG3009	Protein conserved in bacteria
I6L40_20090	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L40_20095	COG0442	prolyl-tRNA aminoacylation
I6L40_20105	COG1309	transcriptional regulator
I6L40_20120	COG4221	oxidoreductase activity
I6L40_20135	COG1024	Enoyl-CoA hydratase
I6L40_20145	COG0110	maltose O-acetyltransferase activity
I6L40_20155	COG4166	transmembrane transport
I6L40_20165	COG0840	transmembrane signaling receptor activity
I6L40_20170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L40_20175	COG0735	belongs to the Fur family
I6L40_20200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L40_20205	COG0513	Belongs to the DEAD box helicase family
I6L40_20210	COG2153	protein acetylation
I6L40_20225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L40_20230	COG0557	exoribonuclease II activity
I6L40_20235	COG3706	GGDEF domain
I6L40_20245	COG3240	lipase activity
I6L40_20260	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L40_20265	COG1194	a g-specific adenine glycosylase
I6L40_20270	COG0617	tRNA 3'-terminal CCA addition
I6L40_20290	COG3068	Protein conserved in bacteria
I6L40_20300	COG0739	heme binding
I6L40_20320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L40_20325	COG1121	(ABC) transporter
I6L40_20330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L40_20335	COG0583	DNA-binding transcription factor activity
I6L40_20340	COG0697	spore germination
I6L40_20345	COG1573	uracil-dna glycosylase
I6L40_20360	COG2827	Endonuclease containing a URI domain
I6L40_20375	COG1842	Phage shock protein A
I6L40_20380	COG0204	Acyl-transferase
I6L40_20400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L40_20405	COG0583	DNA-binding transcription factor activity
I6L40_20445	COG3104	oligopeptide transport
I6L40_20465	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L40_20490	COG0187	DNA topoisomerase II activity
I6L40_20500	COG1566	PFAM secretion protein HlyD family protein
I6L40_20515	COG1051	belongs to the nudix hydrolase family
I6L40_20520	COG3150	esterase
I6L40_20530	COG3151	Protein conserved in bacteria
I6L40_20535	COG0494	nUDIX hydrolase
I6L40_20540	COG1538	Outer membrane efflux protein
I6L40_20545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L40_20545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L40_20550	COG1560	Kdo2-lipid A biosynthetic process
I6L40_20555	COG2213	PTS system mannitol-specific
I6L40_20555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L40_20560	COG0246	Mannitol dehydrogenase
I6L40_20565	COG3722	fumarate hydratase activity
I6L40_20590	COG1671	Belongs to the UPF0178 family
I6L40_20605	COG1988	membrane-bound metal-dependent
I6L40_20610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L40_20615	COG0513	Belongs to the DEAD box helicase family
I6L40_20635	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L40_20640	COG1169	isochorismate synthase
I6L40_20645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L40_20650	COG0596	Alpha beta hydrolase
I6L40_20655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L40_20665	COG0318	PFAM AMP-dependent synthetase and ligase
I6L40_20680	COG3539	Fimbrial protein
I6L40_20685	COG3121	Chaperone
I6L40_20690	COG3188	usher protein
I6L40_20710	COG3291	Pkd domain containing protein
I6L40_20715	COG2949	membrane
I6L40_20720	COG0784	Response regulator, receiver
I6L40_20720	COG0835	chemotaxis
I6L40_20730	COG1444	tRNA N-acetyltransferase activity
I6L40_20750	COG1803	Methylglyoxal synthase
I6L40_20755	COG1979	alcohol dehydrogenase
I6L40_20770	COG4221	oxidoreductase activity
I6L40_20790	COG1285	pathogenesis
I6L40_20810	COG1368	sulfuric ester hydrolase activity
I6L40_20815	COG1522	sequence-specific DNA binding
I6L40_20825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L40_20830	COG1418	mRNA catabolic process
I6L40_20835	COG1058	Belongs to the CinA family
I6L40_20835	COG1546	Belongs to the CinA family
I6L40_20845	COG0561	phosphatase activity
I6L40_20855	COG2926	Belongs to the UPF0265 family
I6L40_20890	COG1396	sequence-specific DNA binding
I6L40_20895	COG3135	benzoate transporter
I6L40_20910	COG0697	spore germination
I6L40_20960	COG1192	Involved in chromosome partitioning