locus-tag	class	description
I6L46_00030	COG3039	Transposase
I6L46_00035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6L46_00050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_00080	COG0745	RESPONSE REGULATOR receiver
I6L46_00085	COG3104	oligopeptide transport
I6L46_00090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L46_00095	COG1555	photosystem II stabilization
I6L46_00100	COG0280	phosphate acetyltransferase
I6L46_00100	COG0857	belongs to the CobB CobQ family
I6L46_00105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L46_00115	COG3013	Belongs to the UPF0304 family
I6L46_00120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6L46_00125	COG2716	regulation of RNA biosynthetic process
I6L46_00130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L46_00135	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6L46_00140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L46_00175	COG0784	Response regulator, receiver
I6L46_00175	COG2198	Histidine kinase
I6L46_00175	COG5002	protein histidine kinase activity
I6L46_00200	COG0840	transmembrane signaling receptor activity
I6L46_00210	COG1464	Belongs to the NlpA lipoprotein family
I6L46_00215	COG2011	ABC-type metal ion transport system permease component
I6L46_00220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L46_00240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L46_00240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6L46_00245	COG0802	atpase or kinase
I6L46_00250	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6L46_00255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L46_00260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L46_00265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L46_00270	COG1923	regulation of RNA biosynthetic process
I6L46_00275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L46_00280	COG0330	HflC and HflK could
I6L46_00285	COG0330	HflC and HflK could
I6L46_00290	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6L46_00295	COG0142	geranyltranstransferase activity
I6L46_00300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L46_00305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L46_00310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L46_00315	COG3314	Sporulation integral membrane protein YlbJ
I6L46_00330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6L46_00345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6L46_00350	COG2967	ApaG domain
I6L46_00355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L46_00360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6L46_00365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L46_00370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6L46_00375	COG3178	'Phosphotransferase
I6L46_00380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6L46_00385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L46_00390	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L46_00395	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6L46_00400	COG1073	alpha beta
I6L46_00415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L46_00430	COG4628	conserved protein (DUF2132)
I6L46_00435	COG0688	phosphatidylethanolamine metabolic process
I6L46_00440	COG1162	GTPase activity
I6L46_00445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6L46_00485	COG1278	Cold shock
I6L46_00495	COG0840	transmembrane signaling receptor activity
I6L46_00500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L46_00505	COG2252	PERMEase
I6L46_00515	COG0488	(ABC) transporter
I6L46_00530	COG0741	lytic transglycosylase activity
I6L46_00540	COG3416	Protein conserved in bacteria
I6L46_00560	COG4608	Belongs to the ABC transporter superfamily
I6L46_00565	COG0444	Belongs to the ABC transporter superfamily
I6L46_00575	COG4239	(ABC) transporter, permease
I6L46_00580	COG4174	ABC transporter (Permease)
I6L46_00595	COG0811	peptide transport
I6L46_00600	COG0811	peptide transport
I6L46_00605	COG0848	biopolymer transport protein
I6L46_00625	COG0616	signal peptide processing
I6L46_00630	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L46_00630	COG1902	pentaerythritol trinitrate reductase activity
I6L46_00635	COG0778	Nitroreductase
I6L46_00645	COG2264	protein methyltransferase activity
I6L46_00650	COG0604	alcohol dehydrogenase
I6L46_00655	COG0583	DNA-binding transcription factor activity
I6L46_00660	COG2190	(PTS) system
I6L46_00660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L46_00660	COG1263	PTS System
I6L46_00665	COG4145	pantothenate transmembrane transporter activity
I6L46_00675	COG0439	Biotin carboxylase
I6L46_00680	COG0511	ligase activity, forming carbon-carbon bonds
I6L46_00685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6L46_00690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L46_00705	COG3381	protein complex oligomerization
I6L46_00715	COG3005	denitrification pathway
I6L46_00720	COG0745	RESPONSE REGULATOR receiver
I6L46_00730	COG1879	ABC-type sugar transport system periplasmic component
I6L46_00735	COG0784	Response regulator, receiver
I6L46_00735	COG2205	protein histidine kinase activity
I6L46_00735	COG2198	Histidine kinase
I6L46_00745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L46_00750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L46_00755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L46_00755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6L46_00770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6L46_00775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L46_00780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6L46_00785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6L46_00800	COG0601	transmembrane transport
I6L46_00810	COG2900	Belongs to the SlyX family
I6L46_00820	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L46_00825	COG2204	response regulator
I6L46_00845	COG0737	Belongs to the 5'-nucleotidase family
I6L46_00850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6L46_00855	COG0142	geranyltranstransferase activity
I6L46_00860	COG1722	exodeoxyribonuclease VII activity
I6L46_00865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L46_00870	COG1360	Flagellar Motor Protein
I6L46_00885	COG1534	Rna-binding protein
I6L46_00890	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6L46_00900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6L46_00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L46_00910	COG0149	triose-phosphate isomerase activity
I6L46_00915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6L46_00930	COG0779	Required for maturation of 30S ribosomal subunits
I6L46_00935	COG0195	Participates in both transcription termination and antitermination
I6L46_00940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L46_00945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L46_00950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L46_00955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L46_00980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L46_00990	COG3721	Heme iron utilization protein
I6L46_00995	COG0748	coenzyme F420 binding
I6L46_01035	COG4104	PAAR repeat-containing protein
I6L46_01075	COG1605	Chorismate mutase
I6L46_01075	COG0077	Prephenate dehydratase
I6L46_01105	COG3272	Protein of unknown function (DUF1722)
I6L46_01110	COG0789	Transcriptional regulator
I6L46_01115	COG0415	Belongs to the DNA photolyase family
I6L46_01125	COG4221	oxidoreductase activity
I6L46_01140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6L46_01170	COG1477	protein flavinylation
I6L46_01175	COG2871	sodium ion transport
I6L46_01180	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L46_01185	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L46_01190	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L46_01195	COG1805	sodium ion transport
I6L46_01200	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6L46_01205	COG0271	Belongs to the BolA IbaG family
I6L46_01210	COG2813	Specifically methylates the guanine in position
I6L46_01220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L46_01225	COG2211	Major facilitator Superfamily
I6L46_01230	COG3248	Nucleoside-binding outer membrane protein
I6L46_01235	COG1666	GTP binding
I6L46_01240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6L46_01255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L46_01260	COG0840	transmembrane signaling receptor activity
I6L46_01265	COG0583	DNA-binding transcription factor activity
I6L46_01275	COG2363	Small membrane protein
I6L46_01280	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
I6L46_01290	COG0473	3-isopropylmalate dehydrogenase activity
I6L46_01295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L46_01300	COG1611	Belongs to the LOG family
I6L46_01315	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L46_01315	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L46_01325	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
I6L46_01350	COG3098	single-species biofilm formation
I6L46_01355	COG0564	pseudouridine synthase activity
I6L46_01365	COG4580	involved in the transport of maltose and maltodextrins
I6L46_01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L46_01375	COG1263	PTS System
I6L46_01385	COG2171	N-acyltransferase activity
I6L46_01395	COG0024	Methionine aminopeptidase
I6L46_01400	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L46_01405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L46_01410	COG0528	UMP kinase activity
I6L46_01415	COG0233	cytoplasmic translational termination
I6L46_01420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L46_01425	COG0575	Belongs to the CDS family
I6L46_01430	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6L46_01435	COG0750	zinc metalloprotease
I6L46_01450	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L46_01455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L46_01460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L46_01465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L46_01470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L46_01480	COG0825	malonyl-CoA metabolic process
I6L46_01490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L46_01495	COG1115	amino acid carrier protein
I6L46_01510	COG0714	Associated with various cellular activities
I6L46_01525	COG3104	oligopeptide transport
I6L46_01530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L46_01535	COG1678	Uncharacterized ACR, COG1678
I6L46_01540	COG0189	ligase activity
I6L46_01545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L46_01555	COG3091	SprT-like family
I6L46_01565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L46_01575	COG0604	alcohol dehydrogenase
I6L46_01575	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_01575	COG3321	synthase
I6L46_01580	COG0583	DNA-binding transcription factor activity
I6L46_01595	COG0251	oxidation-reduction process
I6L46_01605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6L46_01610	COG0739	heme binding
I6L46_01615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L46_01645	COG0814	amino acid
I6L46_01665	COG0531	amino acid
I6L46_01670	COG3710	Transcriptional regulator
I6L46_01675	COG0531	amino acid
I6L46_01680	COG1982	Orn Lys Arg decarboxylase major
I6L46_01685	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L46_01695	COG3590	peptidase
I6L46_01705	COG2203	Gaf domain
I6L46_01705	COG2199	diguanylate cyclase activity
I6L46_01740	COG0366	Alpha amylase catalytic
I6L46_01755	COG0463	Glycosyl transferase, family 2
I6L46_01770	COG2989	Protein conserved in bacteria
I6L46_01775	COG3108	Peptidase M15
I6L46_01785	COG2860	membrane
I6L46_01795	COG1196	nuclear chromosome segregation
I6L46_01800	COG3115	cell septum assembly
I6L46_01805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L46_01815	COG1328	CTP reductase activity
I6L46_01820	COG0602	queuosine metabolic process
I6L46_01850	COG1566	PFAM secretion protein HlyD family protein
I6L46_01855	COG1846	Transcriptional regulator
I6L46_01870	COG0281	malic enzyme
I6L46_01875	COG3290	protein histidine kinase activity
I6L46_01885	COG0697	spore germination
I6L46_01900	COG0346	lactoylglutathione lyase activity
I6L46_01905	COG0745	RESPONSE REGULATOR receiver
I6L46_01910	COG5002	protein histidine kinase activity
I6L46_01935	COG3142	Participates in the control of copper homeostasis
I6L46_01940	COG0545	Peptidyl-prolyl cis-trans isomerase
I6L46_01965	COG0678	peroxiredoxin activity
I6L46_01975	COG0019	diaminopimelate decarboxylase activity
I6L46_01980	COG1115	amino acid carrier protein
I6L46_01985	COG0095	Lipoate-protein ligase
I6L46_01990	COG2233	PERMEase
I6L46_02005	COG0534	Mate efflux family protein
I6L46_02015	COG0281	malic enzyme
I6L46_02050	COG0531	amino acid
I6L46_02055	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L46_02060	COG3706	GGDEF domain
I6L46_02065	COG1566	PFAM secretion protein HlyD family protein
I6L46_02075	COG1032	radical SAM domain protein
I6L46_02100	COG0673	inositol 2-dehydrogenase activity
I6L46_02105	COG2920	part of a sulfur-relay system
I6L46_02110	COG1289	transmembrane transporter activity
I6L46_02115	COG0670	Belongs to the BI1 family
I6L46_02130	COG3623	hexulose-6-phosphate isomerase
I6L46_02135	COG0561	phosphatase activity
I6L46_02160	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6L46_02170	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6L46_02180	COG3156	type II secretion system protein K
I6L46_02185	COG4795	General secretion pathway protein
I6L46_02190	COG2165	general secretion pathway protein
I6L46_02200	COG2165	general secretion pathway protein
I6L46_02205	COG1459	type II secretion system
I6L46_02210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L46_02230	COG3267	Type II secretory pathway component ExeA
I6L46_02230	COG3409	Peptidoglycan-binding domain 1 protein
I6L46_02235	COG2770	Histidine kinase
I6L46_02235	COG3437	response regulator, receiver
I6L46_02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L46_02255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6L46_02260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_02270	COG2190	(PTS) system
I6L46_02275	COG3706	GGDEF domain
I6L46_02280	COG3590	peptidase
I6L46_02290	COG3264	Mechanosensitive ion channel
I6L46_02290	COG1196	nuclear chromosome segregation
I6L46_02295	COG0469	pyruvate kinase activity
I6L46_02305	COG3384	dioxygenase
I6L46_02315	COG0420	3'-5' exonuclease activity
I6L46_02325	COG2974	May be involved in recombination
I6L46_02340	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6L46_02350	COG0531	amino acid
I6L46_02360	COG0531	amino acid
I6L46_02375	COG1396	sequence-specific DNA binding
I6L46_02375	COG1917	Cupin 2, conserved barrel domain protein
I6L46_02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_02395	COG2862	Uncharacterized protein family, UPF0114
I6L46_02415	COG3038	cytochrome b561
I6L46_02420	COG1720	tRNA m6t6A37 methyltransferase activity
I6L46_02440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6L46_02445	COG4988	ABC transporter
I6L46_02460	COG0745	RESPONSE REGULATOR receiver
I6L46_02470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L46_02500	COG0798	PFAM Bile acid sodium symporter
I6L46_02510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L46_02530	COG1988	membrane-bound metal-dependent
I6L46_02545	COG0159	tryptophan synthase activity
I6L46_02550	COG0133	tryptophan synthase activity
I6L46_02555	COG0135	phosphoribosylanthranilate isomerase activity
I6L46_02555	COG0134	indole-3-glycerol-phosphate synthase activity
I6L46_02560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L46_02565	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L46_02565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L46_02570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L46_02580	COG0009	L-threonylcarbamoyladenylate synthase
I6L46_02590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L46_02605	COG1946	Acyl-CoA thioesterase
I6L46_02610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
I6L46_02615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6L46_02625	COG0083	homoserine kinase activity
I6L46_02630	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L46_02650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L46_02670	COG1342	Belongs to the UPF0251 family
I6L46_02685	COG1309	transcriptional regulator
I6L46_02690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_02695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_02705	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L46_02740	COG1086	Polysaccharide biosynthesis protein
I6L46_02785	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6L46_02795	COG0489	protein tyrosine kinase activity
I6L46_02795	COG3206	protein involved in exopolysaccharide biosynthesis
I6L46_02815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L46_02835	COG0577	efflux transmembrane transporter activity
I6L46_02835	COG1136	(ABC) transporter
I6L46_02840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_02845	COG1227	inorganic diphosphatase activity
I6L46_02850	COG0497	DNA recombination
I6L46_02855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L46_02860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L46_02865	COG0443	Heat shock 70 kDa protein
I6L46_02870	COG0484	heat shock protein binding
I6L46_02900	COG1285	pathogenesis
I6L46_02910	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L46_02945	COG1566	PFAM secretion protein HlyD family protein
I6L46_02950	COG0577	efflux transmembrane transporter activity
I6L46_02950	COG1136	(ABC) transporter
I6L46_02955	COG0577	efflux transmembrane transporter activity
I6L46_02955	COG1136	(ABC) transporter
I6L46_02960	COG0577	efflux transmembrane transporter activity
I6L46_02960	COG1136	(ABC) transporter
I6L46_02970	COG0095	Lipoate-protein ligase
I6L46_02980	COG0702	epimerase
I6L46_02985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L46_03015	COG4964	Belongs to the GSP D family
I6L46_03025	COG2894	cell division
I6L46_03065	COG1454	alcohol dehydrogenase
I6L46_03075	COG0564	pseudouridine synthase activity
I6L46_03080	COG1957	nucleoside hydrolase
I6L46_03105	COG1280	lysine exporter protein (LysE YggA)
I6L46_03120	COG3263	regulation of cellular component size
I6L46_03130	COG1876	peptidase activity
I6L46_03135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L46_03140	COG1393	Belongs to the ArsC family
I6L46_03150	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L46_03155	COG1473	amidohydrolase
I6L46_03165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L46_03175	COG0017	Asparaginyl-tRNA synthetase
I6L46_03195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L46_03200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L46_03205	COG0156	8-amino-7-oxononanoate synthase activity
I6L46_03210	COG2226	methyltransferase
I6L46_03210	COG1073	alpha beta
I6L46_03215	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6L46_03220	COG0501	Belongs to the peptidase M48B family
I6L46_03230	COG0633	Ferredoxin
I6L46_03230	COG3217	Mosc domain protein beta barrel domain protein
I6L46_03230	COG0633	Ferredoxin
I6L46_03230	COG3217	Mosc domain protein beta barrel domain protein
I6L46_03245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L46_03245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6L46_03245	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L46_03245	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L46_03255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L46_03260	COG1607	acyl-coa hydrolase
I6L46_03270	COG3021	interspecies interaction between organisms
I6L46_03275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L46_03280	COG2027	D-alanyl-D-alanine carboxypeptidase
I6L46_03285	COG1061	Type III restriction enzyme res subunit
I6L46_03290	COG1566	PFAM secretion protein HlyD family protein
I6L46_03300	COG1966	Carbon starvation protein
I6L46_03305	COG3279	Response regulator of the LytR AlgR family
I6L46_03310	COG3275	phosphorelay sensor kinase activity
I6L46_03315	COG2199	diguanylate cyclase activity
I6L46_03315	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_03320	COG2194	sulfuric ester hydrolase activity
I6L46_03325	COG1846	Transcriptional regulator
I6L46_03325	COG1940	carbohydrate kinase activity
I6L46_03330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L46_03335	COG0363	glucosamine-6-phosphate deaminase activity
I6L46_03340	COG2190	(PTS) system
I6L46_03340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L46_03340	COG1263	PTS System
I6L46_03350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L46_03355	COG0735	belongs to the Fur family
I6L46_03365	COG0716	FMN binding
I6L46_03380	COG0596	Alpha beta hydrolase
I6L46_03385	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6L46_03390	COG0033	Phosphoglucomutase
I6L46_03400	COG1846	Transcriptional regulator
I6L46_03405	COG2951	lytic endotransglycosylase activity
I6L46_03410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L46_03415	COG4136	ATPase activity
I6L46_03420	COG4135	transport system, permease component
I6L46_03425	COG4134	Bacterial extracellular solute-binding protein
I6L46_03435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6L46_03455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L46_03465	COG0729	surface antigen
I6L46_03470	COG2911	Protein conserved in bacteria
I6L46_03490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6L46_03500	COG0741	lytic transglycosylase activity
I6L46_03510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L46_03515	COG4771	TonB-dependent receptor
I6L46_03520	COG1169	isochorismate synthase
I6L46_03525	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6L46_03530	COG3433	isochorismatase activity
I6L46_03530	COG1535	isochorismatase
I6L46_03535	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_03540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L46_03540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6L46_03565	COG1278	Cold shock
I6L46_03590	COG4166	transmembrane transport
I6L46_03595	COG1349	DNA-binding transcription factor activity
I6L46_03600	COG1882	Formate acetyltransferase
I6L46_03605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L46_03610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6L46_03620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_03635	COG4166	transmembrane transport
I6L46_03640	COG0622	Phosphoesterase
I6L46_03655	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L46_03660	COG0835	chemotaxis
I6L46_03660	COG0784	Response regulator, receiver
I6L46_03665	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6L46_03670	COG1815	bacterial-type flagellum-dependent cell motility
I6L46_03680	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6L46_03690	COG4787	bacterial-type flagellum-dependent cell motility
I6L46_03700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L46_03705	COG1706	bacterial-type flagellum-dependent cell motility
I6L46_03720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L46_03725	COG2239	Acts as a magnesium transporter
I6L46_03735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6L46_03740	COG2716	regulation of RNA biosynthetic process
I6L46_03765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6L46_03770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L46_03775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L46_03780	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L46_03800	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6L46_03815	COG0590	tRNA wobble adenosine to inosine editing
I6L46_03820	COG0573	inorganic phosphate transmembrane transporter activity
I6L46_03825	COG0581	inorganic phosphate transmembrane transporter activity
I6L46_03830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L46_03835	COG0704	Plays a role in the regulation of phosphate uptake
I6L46_03840	COG1253	flavin adenine dinucleotide binding
I6L46_03855	COG0531	amino acid
I6L46_03870	COG1126	abc transporter atp-binding protein
I6L46_03875	COG0765	amino acid transport
I6L46_03880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_03885	COG2203	Gaf domain
I6L46_03885	COG2199	diguanylate cyclase activity
I6L46_03890	COG2271	Major facilitator Superfamily
I6L46_03900	COG2197	response regulator
I6L46_03905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L46_03925	COG1785	Belongs to the alkaline phosphatase family
I6L46_03930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L46_03935	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6L46_03945	COG1199	ATP-dependent helicase activity
I6L46_03955	COG1605	Chorismate mutase
I6L46_03955	COG0287	Prephenate dehydrogenase
I6L46_03960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L46_03970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L46_03975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L46_04010	COG0537	adenosine 5'-monophosphoramidase activity
I6L46_04025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6L46_04040	COG1301	dicarboxylic acid transport
I6L46_04055	COG2354	Protein conserved in bacteria
I6L46_04065	COG2233	PERMEase
I6L46_04070	COG3150	esterase
I6L46_04075	COG1252	NADH dehydrogenase
I6L46_04085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L46_04095	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L46_04105	COG2373	Large extracellular alpha-helical protein
I6L46_04110	COG4953	penicillin-binding protein 1C
I6L46_04120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L46_04120	COG0301	tRNA thio-modification
I6L46_04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L46_04145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L46_04150	COG1334	flagellar protein FlaG
I6L46_04175	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_04180	COG1083	cytidylyl-transferase
I6L46_04185	COG0673	inositol 2-dehydrogenase activity
I6L46_04200	COG2089	acid synthase
I6L46_04205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L46_04210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6L46_04235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6L46_04250	COG0483	inositol monophosphate 1-phosphatase activity
I6L46_04260	COG0625	glutathione transferase activity
I6L46_04265	COG2814	Major facilitator Superfamily
I6L46_04290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L46_04295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L46_04300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6L46_04305	COG0509	glycine decarboxylation via glycine cleavage system
I6L46_04310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L46_04310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6L46_04315	COG0840	transmembrane signaling receptor activity
I6L46_04345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6L46_04350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L46_04350	COG0574	Belongs to the PEP-utilizing enzyme family
I6L46_04365	COG1464	Belongs to the NlpA lipoprotein family
I6L46_04370	COG3083	sulfuric ester hydrolase activity
I6L46_04375	COG3082	Protein of unknown function (DUF1414)
I6L46_04380	COG3081	Nucleoid-associated protein
I6L46_04390	COG1175	transmembrane transport
I6L46_04395	COG3833	ABC-type maltose transport systems, permease component
I6L46_04400	COG3842	ATPase activity
I6L46_04425	COG0425	Belongs to the sulfur carrier protein TusA family
I6L46_04430	COG4783	chaperone-mediated protein folding
I6L46_04440	COG1393	Belongs to the ArsC family
I6L46_04450	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
I6L46_04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_04465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6L46_04470	COG2431	L-lysine efflux transmembrane transporter activity
I6L46_04480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_04490	COG4160	amino acid transport
I6L46_04495	COG0564	pseudouridine synthase activity
I6L46_04510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
I6L46_04520	COG0625	glutathione transferase activity
I6L46_04535	COG0367	asparagine synthase
I6L46_04545	COG4651	solute:proton antiporter activity
I6L46_04545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6L46_04550	COG0647	UMP catabolic process
I6L46_04565	COG1902	pentaerythritol trinitrate reductase activity
I6L46_04570	COG1253	flavin adenine dinucleotide binding
I6L46_04580	COG0277	FAD linked oxidase domain protein
I6L46_04580	COG0247	lactate metabolic process
I6L46_04590	COG2050	protein possibly involved in aromatic compounds catabolism
I6L46_04595	COG0513	Belongs to the DEAD box helicase family
I6L46_04600	COG2056	Na+-H+ antiporter family
I6L46_04605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L46_04610	COG0671	phosphoesterase, PA-phosphatase related
I6L46_04615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L46_04620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L46_04630	COG0101	tRNA pseudouridine synthase activity
I6L46_04635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6L46_04640	COG0285	dihydrofolate synthase activity
I6L46_04645	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6L46_04650	COG0393	Putative heavy-metal-binding
I6L46_04660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L46_04660	COG1648	precorrin-2 dehydrogenase activity
I6L46_04680	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L46_04685	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L46_04690	COG1368	sulfuric ester hydrolase activity
I6L46_04705	COG2814	Major facilitator Superfamily
I6L46_04720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L46_04725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L46_04730	COG0539	negative regulation of cytoplasmic translation
I6L46_04735	COG0776	regulation of translation
I6L46_04745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6L46_04765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L46_04770	COG0602	queuosine metabolic process
I6L46_04775	COG3530	Putative quorum-sensing-regulated virulence factor
I6L46_04780	COG2096	Adenosyltransferase
I6L46_04785	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6L46_04790	COG1757	Na H antiporter
I6L46_04795	COG1435	thymidine kinase activity
I6L46_04870	COG3829	transcription factor binding
I6L46_04900	COG3501	Rhs element vgr protein
I6L46_04950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L46_04955	COG0326	Molecular chaperone. Has ATPase activity
I6L46_04960	COG4172	Belongs to the ABC transporter superfamily
I6L46_04965	COG4172	Belongs to the ABC transporter superfamily
I6L46_04975	COG4168	peptide transport system, permease
I6L46_04985	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6L46_04990	COG1842	Phage shock protein A
I6L46_05005	COG3106	COG3106 Predicted ATPase
I6L46_05010	COG3768	UPF0283 membrane protein
I6L46_05020	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6L46_05040	COG2199	diguanylate cyclase activity
I6L46_05045	COG2885	chlorophyll binding
I6L46_05050	COG0861	Integral membrane protein TerC family
I6L46_05080	COG2910	NAD(P)H-binding
I6L46_05085	COG0583	DNA-binding transcription factor activity
I6L46_05090	COG0583	DNA-binding transcription factor activity
I6L46_05095	COG2271	Major facilitator Superfamily
I6L46_05105	COG1335	isochorismatase
I6L46_05120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L46_05130	COG0583	DNA-binding transcription factor activity
I6L46_05135	COG2723	6-phospho-beta-galactosidase activity
I6L46_05140	COG1944	ATP diphosphatase activity
I6L46_05145	COG2116	formate transmembrane transporter activity
I6L46_05150	COG1882	Formate acetyltransferase
I6L46_05155	COG2983	Belongs to the UPF0260 family
I6L46_05160	COG4166	transmembrane transport
I6L46_05165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
I6L46_05170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L46_05180	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L46_05185	COG1136	(ABC) transporter
I6L46_05190	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L46_05195	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6L46_05205	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L46_05210	COG0740	serine-type endopeptidase activity
I6L46_05215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L46_05220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6L46_05225	COG0776	regulation of translation
I6L46_05230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L46_05235	COG0488	(ABC) transporter
I6L46_05240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L46_05245	COG3162	membrane
I6L46_05260	COG1024	Enoyl-CoA hydratase
I6L46_05310	COG1115	amino acid carrier protein
I6L46_05325	COG1584	GPR1 FUN34 yaaH family protein
I6L46_05355	COG1024	Enoyl-CoA hydratase
I6L46_05360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6L46_05365	COG1960	acyl-CoA dehydrogenase activity
I6L46_05370	COG1960	acyl-CoA dehydrogenase activity
I6L46_05375	COG1024	Enoyl-CoA hydratase
I6L46_05380	COG1024	Enoyl-CoA hydratase
I6L46_05390	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_05405	COG0730	response to heat
I6L46_05415	COG0784	Response regulator, receiver
I6L46_05415	COG2205	protein histidine kinase activity
I6L46_05455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6L46_05460	COG1215	transferase activity, transferring glycosyl groups
I6L46_05465	COG0438	transferase activity, transferring glycosyl groups
I6L46_05510	COG0438	transferase activity, transferring glycosyl groups
I6L46_05530	COG0438	transferase activity, transferring glycosyl groups
I6L46_05535	COG0438	transferase activity, transferring glycosyl groups
I6L46_05540	COG5001	Diguanylate cyclase
I6L46_05540	COG2203	Gaf domain
I6L46_05540	COG4251	negative regulation of phosphorylation
I6L46_05540	COG3706	GGDEF domain
I6L46_05545	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_05550	COG3437	response regulator, receiver
I6L46_05555	COG2205	protein histidine kinase activity
I6L46_05555	COG3437	response regulator, receiver
I6L46_05555	COG3850	Histidine kinase
I6L46_05555	COG4999	Histidine kinase
I6L46_05560	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6L46_05565	COG0437	4 iron, 4 sulfur cluster binding
I6L46_05570	COG5557	Pfam Polysulphide reductase, NrfD
I6L46_05575	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6L46_05580	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L46_05585	COG1773	rubredoxin
I6L46_05595	COG0601	transmembrane transport
I6L46_05600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L46_05605	COG0444	Belongs to the ABC transporter superfamily
I6L46_05610	COG1124	(ABC) transporter
I6L46_05615	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6L46_05620	COG0375	protein maturation
I6L46_05625	COG0309	Hydrogenase expression formation protein (HypE)
I6L46_05635	COG0298	carbon dioxide binding
I6L46_05640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6L46_05650	COG1921	L-seryl-tRNASec selenium transferase activity
I6L46_05660	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6L46_05670	COG3260	NADH ubiquinone oxidoreductase 20
I6L46_05675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_05680	COG3261	NADH dehydrogenase
I6L46_05680	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6L46_05685	COG0650	Formate hydrogenlyase subunit 4
I6L46_05690	COG0651	ATP synthesis coupled electron transport
I6L46_05695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L46_05700	COG3158	transport of potassium into the cell
I6L46_05720	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L46_05745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L46_05750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_05755	COG3046	protein related to deoxyribodipyrimidine photolyase
I6L46_05765	COG3033	Beta-eliminating lyase
I6L46_05770	COG0295	cytidine deaminase activity
I6L46_05775	COG1346	cytolysis
I6L46_05780	COG1380	Effector of murein hydrolase LrgA
I6L46_05785	COG3345	alpha-galactosidase
I6L46_05795	COG2925	Exonuclease
I6L46_05800	COG0641	radical SAM
I6L46_05825	COG2304	oxidoreductase activity
I6L46_05830	COG2304	oxidoreductase activity
I6L46_05845	COG0714	Associated with various cellular activities
I6L46_05850	COG3119	arylsulfatase activity
I6L46_05860	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_05865	COG0617	tRNA 3'-terminal CCA addition
I6L46_05865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L46_05865	COG0517	IMP dehydrogenase activity
I6L46_05870	COG1643	Atp-dependent helicase
I6L46_05880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6L46_05895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I6L46_05900	COG2067	long-chain fatty acid transport protein
I6L46_05905	COG2067	long-chain fatty acid transport protein
I6L46_05915	COG1595	DNA-templated transcription, initiation
I6L46_05925	COG2304	oxidoreductase activity
I6L46_05945	COG0714	Associated with various cellular activities
I6L46_05950	COG0183	Belongs to the thiolase family
I6L46_05955	COG1024	Enoyl-CoA hydratase
I6L46_05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L46_05960	COG2719	SpoVR family
I6L46_05965	COG2718	Belongs to the UPF0229 family
I6L46_05970	COG2766	serine protein kinase
I6L46_05975	COG0514	ATP-dependent DNA helicase (RecQ)
I6L46_05980	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6L46_05985	COG0814	amino acid
I6L46_05990	COG0494	nUDIX hydrolase
I6L46_06005	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L46_06025	COG0406	alpha-ribazole phosphatase activity
I6L46_06030	COG3706	GGDEF domain
I6L46_06035	COG2840	Smr protein MutS2
I6L46_06040	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L46_06045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L46_06055	COG0513	Belongs to the DEAD box helicase family
I6L46_06065	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6L46_06075	COG0814	amino acid
I6L46_06080	COG1609	Transcriptional regulator
I6L46_06085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_06085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_06090	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L46_06095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_06095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_06095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6L46_06100	COG3313	Fe-S protein
I6L46_06105	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6L46_06110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L46_06115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L46_06120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L46_06130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L46_06140	COG0366	Alpha amylase catalytic
I6L46_06155	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L46_06160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L46_06165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L46_06170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L46_06180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L46_06185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L46_06185	COG0072	phenylalanine-tRNA ligase activity
I6L46_06190	COG0776	regulation of translation
I6L46_06195	COG0784	Response regulator, receiver
I6L46_06195	COG2205	protein histidine kinase activity
I6L46_06220	COG3300	MHYT domain
I6L46_06220	COG5001	Diguanylate cyclase
I6L46_06225	COG1609	Transcriptional regulator
I6L46_06230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L46_06235	COG1879	ABC-type sugar transport system periplasmic component
I6L46_06240	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6L46_06245	COG1129	ABC transporter
I6L46_06250	COG1869	D-ribose catabolic process
I6L46_06255	COG0625	glutathione transferase activity
I6L46_06265	COG1177	transmembrane transport
I6L46_06295	COG0037	tRNA processing
I6L46_06300	COG0589	response to stress
I6L46_06305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L46_06320	COG2217	Heavy metal translocating P-type atpase
I6L46_06330	COG2010	Cytochrome c
I6L46_06345	COG3278	Belongs to the heme-copper respiratory oxidase family
I6L46_06355	COG1956	GAF domain-containing protein
I6L46_06360	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6L46_06370	COG0308	aminopeptidase N
I6L46_06380	COG2902	Dehydrogenase
I6L46_06385	COG0167	dihydroorotate dehydrogenase activity
I6L46_06400	COG0254	rRNA binding
I6L46_06405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L46_06410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L46_06410	COG0116	Belongs to the methyltransferase superfamily
I6L46_06420	COG0488	(ABC) transporter
I6L46_06430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L46_06435	COG1067	ATP-dependent peptidase activity
I6L46_06475	COG4128	Pfam Zonular occludens toxin
I6L46_06520	COG3141	response to X-ray
I6L46_06525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L46_06535	COG4221	oxidoreductase activity
I6L46_06580	COG0372	Belongs to the citrate synthase family
I6L46_06585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6L46_06595	COG2995	paraquat-inducible protein a
I6L46_06600	COG3008	intermembrane lipid transfer
I6L46_06605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L46_06605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L46_06620	COG0084	hydrolase, TatD family'
I6L46_06625	COG0470	DNA polymerase III
I6L46_06630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L46_06635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L46_06640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L46_06645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L46_06650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L46_06655	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_06665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L46_06670	COG0416	fatty acid biosynthetic process
I6L46_06675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L46_06680	COG1399	metal-binding, possibly nucleic acid-binding protein
I6L46_06685	COG0424	maF-like protein
I6L46_06700	COG1530	ribonuclease E activity
I6L46_06710	COG0306	phosphate transporter
I6L46_06715	COG0717	Belongs to the dCTP deaminase family
I6L46_06720	COG0572	uridine kinase
I6L46_06725	COG0489	protein tyrosine kinase activity
I6L46_06730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L46_06730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L46_06740	COG1254	Belongs to the acylphosphatase family
I6L46_06745	COG0840	transmembrane signaling receptor activity
I6L46_06750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L46_06760	COG0709	Synthesizes selenophosphate from selenide and ATP
I6L46_06765	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6L46_06770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L46_06780	COG0318	PFAM AMP-dependent synthetase and ligase
I6L46_06785	COG2267	carboxylic ester hydrolase activity
I6L46_06795	COG1214	PFAM Peptidase M22, glycoprotease
I6L46_06800	COG1199	ATP-dependent helicase activity
I6L46_06810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L46_06815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L46_06820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L46_06825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L46_06825	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L46_06830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L46_06835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L46_06840	COG0107	imidazoleglycerol-phosphate synthase activity
I6L46_06855	COG2199	diguanylate cyclase activity
I6L46_06860	COG0318	PFAM AMP-dependent synthetase and ligase
I6L46_06865	COG1288	antiporter activity
I6L46_06875	COG3134	Outer membrane lipoprotein
I6L46_06880	COG2080	2 iron, 2 sulfur cluster binding
I6L46_06885	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L46_06890	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L46_06895	COG2252	PERMEase
I6L46_06900	COG0402	S-adenosylhomocysteine deaminase activity
I6L46_06905	COG2233	PERMEase
I6L46_06910	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6L46_06910	COG2080	2 iron, 2 sulfur cluster binding
I6L46_06915	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6L46_06920	COG0402	S-adenosylhomocysteine deaminase activity
I6L46_06925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L46_06925	COG0493	'glutamate synthase
I6L46_06930	COG2068	MobA-Related Protein
I6L46_06935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L46_06940	COG3608	succinylglutamate desuccinylase aspartoacylase
I6L46_06940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6L46_06950	COG0697	spore germination
I6L46_06955	COG0549	Belongs to the carbamate kinase family
I6L46_06965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L46_06970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L46_06975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L46_07020	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6L46_07025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6L46_07035	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6L46_07040	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6L46_07050	COG0205	6-phosphofructokinase activity
I6L46_07060	COG3123	guanosine phosphorylase activity
I6L46_07065	COG1760	l-serine dehydratase
I6L46_07070	COG1760	l-serine dehydratase
I6L46_07075	COG3100	YcgL domain-containing protein
I6L46_07080	COG0850	regulation of cytokinetic process
I6L46_07085	COG2894	cell division
I6L46_07090	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6L46_07095	COG3099	Belongs to the UPF0263 family
I6L46_07100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L46_07140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L46_07145	COG0697	spore germination
I6L46_07150	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6L46_07155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L46_07165	COG0307	riboflavin synthase, alpha
I6L46_07210	COG3829	transcription factor binding
I6L46_07225	COG4681	YaeQ
I6L46_07240	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L46_07245	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6L46_07255	COG0586	Pfam SNARE associated Golgi protein
I6L46_07265	COG0556	nucleotide-excision repair
I6L46_07275	COG0569	domain protein
I6L46_07275	COG2985	domain, Protein
I6L46_07285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L46_07290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_07290	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6L46_07305	COG3069	C4-dicarboxylate transmembrane transporter activity
I6L46_07320	COG1451	nucleotide metabolic process
I6L46_07335	COG0417	DNA replication proofreading
I6L46_07365	COG1560	Kdo2-lipid A biosynthetic process
I6L46_07370	COG1560	Kdo2-lipid A biosynthetic process
I6L46_07385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6L46_07390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L46_07395	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L46_07400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L46_07405	COG2832	Protein of unknown function (DUF454)
I6L46_07410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L46_07425	COG1011	Hydrolase
I6L46_07430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L46_07480	COG3593	DNA synthesis involved in DNA repair
I6L46_07495	COG0583	DNA-binding transcription factor activity
I6L46_07500	COG0730	response to heat
I6L46_07505	COG3148	PFAM DTW domain containing protein
I6L46_07510	COG1940	carbohydrate kinase activity
I6L46_07510	COG1846	Transcriptional regulator
I6L46_07515	COG0840	transmembrane signaling receptor activity
I6L46_07520	COG3012	SEC-C Motif Domain Protein
I6L46_07530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6L46_07535	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I6L46_07540	COG0247	lactate metabolic process
I6L46_07555	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6L46_07560	COG0437	4 iron, 4 sulfur cluster binding
I6L46_07565	COG3301	Polysulphide reductase, NrfD
I6L46_07570	COG1138	Cytochrome C-type biogenesis protein
I6L46_07580	COG3088	subunit of a heme lyase
I6L46_07580	COG4235	cytochrome complex assembly
I6L46_07595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L46_07605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6L46_07615	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L46_07620	COG3842	ATPase activity
I6L46_07630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_07645	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L46_07650	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L46_07655	COG0567	Dehydrogenase, E1 component
I6L46_07665	COG1053	succinate dehydrogenase
I6L46_07670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6L46_07675	COG2009	succinate dehydrogenase
I6L46_07715	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6L46_07730	COG2501	S4 domain
I6L46_07740	COG1132	(ABC) transporter
I6L46_07745	COG1132	(ABC) transporter
I6L46_07755	COG3118	belongs to the thioredoxin family
I6L46_07760	COG0471	metal ion transport
I6L46_07765	COG0058	SHG alpha-glucan phosphorylase activity
I6L46_07780	COG0697	spore germination
I6L46_07790	COG2062	phosphohistidine phosphatase, SixA
I6L46_07795	COG1025	Belongs to the peptidase M16 family
I6L46_07815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L46_07815	COG2169	Transcriptional regulator
I6L46_07835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L46_07835	COG0519	Catalyzes the synthesis of GMP from XMP
I6L46_07840	COG0516	GMP reductase activity
I6L46_07840	COG0517	IMP dehydrogenase activity
I6L46_07845	COG3038	cytochrome b561
I6L46_07850	COG1570	exodeoxyribonuclease VII activity
I6L46_07855	COG2188	Transcriptional regulator
I6L46_07860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_07860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_07860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_07865	COG0383	alpha-mannosidase activity
I6L46_07870	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L46_07880	COG0386	Belongs to the glutathione peroxidase family
I6L46_07885	COG0513	Belongs to the DEAD box helicase family
I6L46_07900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L46_07905	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L46_07910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L46_07960	COG5001	Diguanylate cyclase
I6L46_07960	COG3300	MHYT domain
I6L46_07975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L46_07985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L46_07990	COG0563	adenylate kinase activity
I6L46_08000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L46_08005	COG1286	toxin biosynthetic process
I6L46_08015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L46_08020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L46_08025	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6L46_08030	COG0531	amino acid
I6L46_08030	COG1674	ftsk spoiiie
I6L46_08040	COG0686	Belongs to the AlaDH PNT family
I6L46_08045	COG0492	ferredoxin-NADP+ reductase activity
I6L46_08050	COG3706	GGDEF domain
I6L46_08055	COG3134	Outer membrane lipoprotein
I6L46_08060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6L46_08065	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6L46_08070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L46_08075	COG0542	response to heat
I6L46_08080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6L46_08085	COG1278	Cold shock
I6L46_08090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L46_08110	COG0745	RESPONSE REGULATOR receiver
I6L46_08115	COG2205	protein histidine kinase activity
I6L46_08125	COG0392	lysyltransferase activity
I6L46_08125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6L46_08135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6L46_08155	COG4974	Belongs to the 'phage' integrase family
I6L46_08170	COG0659	secondary active sulfate transmembrane transporter activity
I6L46_08205	COG0672	)-iron permease
I6L46_08230	COG2814	Major facilitator Superfamily
I6L46_08245	COG1136	(ABC) transporter
I6L46_08250	COG0577	efflux transmembrane transporter activity
I6L46_08260	COG1285	pathogenesis
I6L46_08275	COG0596	Alpha beta hydrolase
I6L46_08295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L46_08300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L46_08300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6L46_08305	COG0527	aspartate kinase activity
I6L46_08325	COG0778	Nitroreductase
I6L46_08330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6L46_08335	COG3300	MHYT domain
I6L46_08335	COG5001	Diguanylate cyclase
I6L46_08340	COG0583	DNA-binding transcription factor activity
I6L46_08345	COG3437	response regulator, receiver
I6L46_08370	COG4989	oxidoreductase activity
I6L46_08375	COG0724	RNA recognition motif
I6L46_08385	COG1126	abc transporter atp-binding protein
I6L46_08390	COG0765	amino acid transport
I6L46_08395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_08400	COG4597	amino acid ABC transporter
I6L46_08405	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6L46_08415	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6L46_08490	COG5642	Protein of unknown function (DUF2384)
I6L46_08505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L46_08510	COG1360	Flagellar Motor Protein
I6L46_08515	COG4771	TonB-dependent receptor
I6L46_08520	COG1770	oligopeptidase
I6L46_08540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_08545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_08550	COG0649	NAD binding
I6L46_08550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_08565	COG1034	ATP synthesis coupled electron transport
I6L46_08570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6L46_08575	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_08580	COG0839	Belongs to the complex I subunit 6 family
I6L46_08585	COG0713	ATP synthesis coupled electron transport
I6L46_08595	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_08600	COG1007	ATP synthesis coupled electron transport
I6L46_08615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_08615	COG2199	diguanylate cyclase activity
I6L46_08620	COG0047	phosphoribosylformylglycinamidine synthase activity
I6L46_08620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L46_08625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L46_08630	COG1645	bacterial-type flagellum-dependent swarming motility
I6L46_08635	COG1160	GTP binding
I6L46_08640	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L46_08645	COG2976	Protein conserved in bacteria
I6L46_08650	COG0124	histidyl-tRNA synthetase
I6L46_08670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L46_08675	COG0105	UTP biosynthetic process
I6L46_08690	COG0633	Ferredoxin
I6L46_08695	COG0443	Heat shock 70 kDa protein
I6L46_08700	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6L46_08710	COG0822	iron-sulfur transferase activity
I6L46_08715	COG1104	cysteine desulfurase activity
I6L46_08735	COG3154	lipid carrier protein
I6L46_08740	COG0826	peptidase U32
I6L46_08745	COG0826	peptidase U32
I6L46_08760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L46_08765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6L46_08770	COG1862	Preprotein translocase
I6L46_08775	COG0343	queuine tRNA-ribosyltransferase activity
I6L46_08780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L46_08785	COG0517	IMP dehydrogenase activity
I6L46_08795	COG3634	alkyl hydroperoxide reductase activity
I6L46_08840	COG1242	4 iron, 4 sulfur cluster binding
I6L46_08845	COG0067	glutamate synthase
I6L46_08845	COG0070	glutamate synthase
I6L46_08845	COG0069	glutamate synthase activity
I6L46_08850	COG0493	'glutamate synthase
I6L46_08860	COG0513	Belongs to the DEAD box helicase family
I6L46_08885	COG0023	Translation Initiation Factor
I6L46_08890	COG2119	membrane
I6L46_08940	COG0215	cysteine-tRNA ligase activity
I6L46_08945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6L46_08955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6L46_08965	COG2261	transglycosylase associated protein
I6L46_08970	COG0642	Histidine kinase
I6L46_09075	COG0322	excinuclease ABC activity
I6L46_09080	COG2197	response regulator
I6L46_09085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6L46_09090	COG2835	tetraacyldisaccharide 4'-kinase activity
I6L46_09095	COG1663	tetraacyldisaccharide 4'-kinase activity
I6L46_09100	COG1132	(ABC) transporter
I6L46_09105	COG2333	competence protein COMEC
I6L46_09105	COG0658	competence protein
I6L46_09120	COG1448	Aminotransferase
I6L46_09130	COG0583	DNA-binding transcription factor activity
I6L46_09135	COG3085	chromosome segregation
I6L46_09140	COG4574	serine-type endopeptidase inhibitor activity
I6L46_09145	COG0584	glycerophosphoryl diester phosphodiesterase
I6L46_09155	COG1349	DNA-binding transcription factor activity
I6L46_09160	COG2271	Major facilitator Superfamily
I6L46_09165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L46_09170	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6L46_09175	COG0840	transmembrane signaling receptor activity
I6L46_09185	COG0583	DNA-binding transcription factor activity
I6L46_09210	COG0656	L-ascorbic acid biosynthetic process
I6L46_09215	COG2814	Major facilitator Superfamily
I6L46_09220	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L46_09235	COG3220	belongs to the UPF0276 family
I6L46_09255	COG1294	oxidase, subunit
I6L46_09265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L46_09275	COG2979	Protein of unknown function (DUF533)
I6L46_09290	COG0583	DNA-binding transcription factor activity
I6L46_09295	COG2807	transmembrane transport
I6L46_09300	COG1187	pseudouridine synthase activity
I6L46_09310	COG0346	lactoylglutathione lyase activity
I6L46_09320	COG1061	Type III restriction enzyme res subunit
I6L46_09325	COG4657	Part of a membrane complex involved in electron transport
I6L46_09330	COG2878	Part of a membrane complex involved in electron transport
I6L46_09340	COG4658	electron transport chain
I6L46_09345	COG4659	FMN binding
I6L46_09350	COG4660	Part of a membrane complex involved in electron transport
I6L46_09355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L46_09360	COG0346	lactoylglutathione lyase activity
I6L46_09400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L46_09405	COG0505	Belongs to the CarA family
I6L46_09410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L46_09425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L46_09430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L46_09435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L46_09440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L46_09445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L46_09455	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
I6L46_09485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L46_09490	COG0861	Integral membrane protein TerC family
I6L46_09505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L46_09510	COG0601	transmembrane transport
I6L46_09520	COG2095	MarC family integral membrane protein
I6L46_09525	COG1012	belongs to the aldehyde dehydrogenase family
I6L46_09525	COG1454	alcohol dehydrogenase
I6L46_09530	COG0217	transcriptional regulatory protein
I6L46_09535	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L46_09545	COG1801	Protein of unknown function DUF72
I6L46_09550	COG4106	trans-aconitate 2-methyltransferase activity
I6L46_09555	COG0500	methyltransferase
I6L46_09575	COG0450	alkyl hydroperoxide reductase
I6L46_09580	COG0583	DNA-binding transcription factor activity
I6L46_09585	COG0791	NLP P60 protein
I6L46_09595	COG0583	DNA-binding transcription factor activity
I6L46_09600	COG2610	gluconate transmembrane transporter activity
I6L46_09605	COG3048	D-serine ammonia-lyase activity
I6L46_09615	COG0538	isocitrate dehydrogenase activity
I6L46_09620	COG2207	Transcriptional regulator
I6L46_09625	COG1482	cell wall glycoprotein biosynthetic process
I6L46_09630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_09645	COG3152	Membrane
I6L46_09680	COG1309	transcriptional regulator
I6L46_09710	COG0534	Mate efflux family protein
I6L46_09720	COG2841	Protein conserved in bacteria
I6L46_09730	COG5001	Diguanylate cyclase
I6L46_09730	COG3300	MHYT domain
I6L46_09735	COG3132	Protein of unknown function, DUF480
I6L46_09765	COG0708	Exodeoxyribonuclease III
I6L46_09800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_09805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_09815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L46_09820	COG1120	ATPase activity
I6L46_09825	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L46_09830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L46_09835	COG2375	cellular response to nickel ion
I6L46_09840	COG3437	response regulator, receiver
I6L46_09840	COG0784	Response regulator, receiver
I6L46_09850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L46_09855	COG0328	RNA-DNA hybrid ribonuclease activity
I6L46_09860	COG2226	methyltransferase
I6L46_09865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6L46_09870	COG0741	lytic transglycosylase activity
I6L46_09870	COG1388	LysM domain
I6L46_09895	COG5000	phosphorelay sensor kinase activity
I6L46_09895	COG5002	protein histidine kinase activity
I6L46_09900	COG0745	RESPONSE REGULATOR receiver
I6L46_09905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_09910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_09920	COG1376	ErfK ybiS ycfS ynhG family protein
I6L46_09920	COG1388	LysM domain
I6L46_09930	COG0471	metal ion transport
I6L46_09940	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
I6L46_09945	COG0791	NLP P60 protein
I6L46_09955	COG3118	belongs to the thioredoxin family
I6L46_09965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6L46_09970	COG0788	formyltetrahydrofolate deformylase activity
I6L46_09980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L46_09995	COG0739	heme binding
I6L46_09995	COG0741	lytic transglycosylase activity
I6L46_09995	COG1196	nuclear chromosome segregation
I6L46_10000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6L46_10010	COG0436	Aminotransferase
I6L46_10015	COG1288	antiporter activity
I6L46_10020	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L46_10030	COG2964	Protein conserved in bacteria
I6L46_10035	COG3681	Belongs to the UPF0597 family
I6L46_10045	COG0814	amino acid
I6L46_10065	COG1166	arginine decarboxylase activity
I6L46_10070	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L46_10085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6L46_10095	COG2353	YceI-like domain
I6L46_10100	COG0583	DNA-binding transcription factor activity
I6L46_10110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L46_10115	COG0840	transmembrane signaling receptor activity
I6L46_10120	COG0302	gtp cyclohydrolase
I6L46_10130	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L46_10145	COG2267	carboxylic ester hydrolase activity
I6L46_10150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6L46_10165	COG0314	molybdopterin synthase activity
I6L46_10170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6L46_10175	COG0315	cyclic pyranopterin monophosphate synthase activity
I6L46_10180	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L46_10185	COG3005	denitrification pathway
I6L46_10195	COG0348	domain, Protein
I6L46_10200	COG0437	4 iron, 4 sulfur cluster binding
I6L46_10205	COG0243	molybdopterin cofactor binding
I6L46_10215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L46_10220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6L46_10225	COG3850	Histidine kinase
I6L46_10230	COG2197	response regulator
I6L46_10260	COG0121	glutamine amidotransferase
I6L46_10265	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L46_10270	COG1960	acyl-CoA dehydrogenase activity
I6L46_10275	COG1473	amidohydrolase
I6L46_10280	COG2914	Belongs to the UPF0125 (RnfH) family
I6L46_10285	COG2867	negative regulation of translational initiation
I6L46_10290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L46_10300	COG0784	Response regulator, receiver
I6L46_10300	COG2205	protein histidine kinase activity
I6L46_10310	COG3383	formate dehydrogenase (NAD+) activity
I6L46_10320	COG0477	Major facilitator Superfamily
I6L46_10320	COG2814	Major facilitator Superfamily
I6L46_10325	COG0457	Tetratricopeptide repeat
I6L46_10330	COG1940	carbohydrate kinase activity
I6L46_10340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6L46_10350	COG1960	acyl-CoA dehydrogenase activity
I6L46_10355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_10365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6L46_10370	COG1317	bacterial-type flagellum organization
I6L46_10460	COG0457	Tetratricopeptide repeat
I6L46_10530	COG4790	Type iii secretion
I6L46_10535	COG4794	Type iii secretion
I6L46_10540	COG4791	protein targeting
I6L46_10545	COG4792	protein secretion
I6L46_10585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_10585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_10585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_10590	COG2271	Major facilitator Superfamily
I6L46_10595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L46_10615	COG0482	sulfurtransferase activity
I6L46_10620	COG2915	High frequency lysogenization protein hflD homolog
I6L46_10625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L46_10630	COG2850	peptidyl-arginine hydroxylation
I6L46_10650	COG0625	glutathione transferase activity
I6L46_10655	COG0259	pyridoxamine-phosphate oxidase activity
I6L46_10685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L46_10685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L46_10695	COG1882	Formate acetyltransferase
I6L46_10700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L46_10710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L46_10715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6L46_10725	COG2853	Lipoprotein
I6L46_10735	COG3088	subunit of a heme lyase
I6L46_10735	COG4235	cytochrome complex assembly
I6L46_10740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L46_10745	COG1138	Cytochrome C-type biogenesis protein
I6L46_10750	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6L46_10755	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L46_10760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L46_10765	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6L46_10780	COG0835	chemotaxis
I6L46_10790	COG1192	Involved in chromosome partitioning
I6L46_10795	COG1360	Flagellar Motor Protein
I6L46_10800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L46_10805	COG2201	protein-glutamate methylesterase activity
I6L46_10810	COG0643	Histidine kinase
I6L46_10810	COG2198	Histidine kinase
I6L46_10810	COG0784	Response regulator, receiver
I6L46_10815	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6L46_10840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6L46_10850	COG1684	flagellar biosynthetic protein fliR
I6L46_10855	COG1987	bacterial-type flagellum assembly
I6L46_10905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L46_10915	COG1677	Flagellar hook-basal body complex protein FliE
I6L46_10935	COG0469	pyruvate kinase activity
I6L46_10940	COG1737	Transcriptional regulator
I6L46_10945	COG0837	glucose binding
I6L46_10975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_10995	COG0281	malic enzyme
I6L46_11015	COG0437	4 iron, 4 sulfur cluster binding
I6L46_11020	COG3383	formate dehydrogenase (NAD+) activity
I6L46_11020	COG3383	formate dehydrogenase (NAD+) activity
I6L46_11055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6L46_11065	COG3852	Histidine kinase
I6L46_11070	COG2204	response regulator
I6L46_11080	COG4662	Binding-protein-dependent transport system inner membrane component
I6L46_11090	COG0746	molybdenum cofactor guanylyltransferase activity
I6L46_11095	COG0303	'Molybdopterin
I6L46_11100	COG1289	transmembrane transporter activity
I6L46_11105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6L46_11135	COG3220	belongs to the UPF0276 family
I6L46_11165	COG2205	protein histidine kinase activity
I6L46_11165	COG0784	Response regulator, receiver
I6L46_11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L46_11185	COG0444	Belongs to the ABC transporter superfamily
I6L46_11190	COG4608	Belongs to the ABC transporter superfamily
I6L46_11200	COG2971	BadF BadG BcrA BcrD
I6L46_11210	COG0840	transmembrane signaling receptor activity
I6L46_11230	COG3724	N-succinylarginine dihydrolase activity
I6L46_11255	COG0826	peptidase U32
I6L46_11260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6L46_11270	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L46_11275	COG2211	Major facilitator Superfamily
I6L46_11280	COG0616	signal peptide processing
I6L46_11285	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_11290	COG0583	DNA-binding transcription factor activity
I6L46_11300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L46_11315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L46_11320	COG1881	PFAM PEBP family protein
I6L46_11330	COG3408	Glycogen debranching enzyme
I6L46_11330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6L46_11340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L46_11355	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6L46_11360	COG2912	Transglutaminase-like superfamily
I6L46_11370	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L46_11375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L46_11380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6L46_11385	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6L46_11390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L46_11400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L46_11405	COG0737	Belongs to the 5'-nucleotidase family
I6L46_11410	COG0193	aminoacyl-tRNA hydrolase activity
I6L46_11415	COG0012	GTP binding
I6L46_11460	COG0490	domain, Protein
I6L46_11460	COG0471	metal ion transport
I6L46_11470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6L46_11480	COG3097	Belongs to the UPF0267 family
I6L46_11495	COG0366	Alpha amylase catalytic
I6L46_11500	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6L46_11500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6L46_11500	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6L46_11500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6L46_11510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L46_11525	COG1012	belongs to the aldehyde dehydrogenase family
I6L46_11535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L46_11540	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L46_11550	COG0180	Tryptophanyl-tRNA synthetase
I6L46_11560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6L46_11565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6L46_11575	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L46_11580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L46_11610	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6L46_11615	COG0583	DNA-binding transcription factor activity
I6L46_11635	COG0583	DNA-binding transcription factor activity
I6L46_11645	COG0739	heme binding
I6L46_11655	COG1511	domain protein
I6L46_11655	COG3264	Mechanosensitive ion channel
I6L46_11660	COG0584	glycerophosphoryl diester phosphodiesterase
I6L46_11670	COG1053	succinate dehydrogenase
I6L46_11675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6L46_11680	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L46_11685	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
I6L46_11690	COG3366	ferrous iron transmembrane transporter activity
I6L46_11695	COG0700	Nucleoside recognition
I6L46_11700	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L46_11710	COG3214	Protein conserved in bacteria
I6L46_11725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_11740	COG1022	Amp-dependent synthetase and ligase
I6L46_11750	COG4221	oxidoreductase activity
I6L46_11765	COG0642	Histidine kinase
I6L46_11785	COG0516	GMP reductase activity
I6L46_11795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L46_11805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L46_11830	COG0583	DNA-binding transcription factor activity
I6L46_11835	COG3706	GGDEF domain
I6L46_11845	COG1335	isochorismatase
I6L46_11850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6L46_11855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6L46_11860	COG1702	phosphate starvation-inducible protein PhoH
I6L46_11865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L46_11870	COG4535	Mg2 and Co2 transporter CorC
I6L46_11875	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6L46_11880	COG0789	Transcriptional regulator
I6L46_11895	COG1970	mechanosensitive ion channel activity
I6L46_11900	COG4974	Belongs to the 'phage' integrase family
I6L46_11905	COG0716	FMN binding
I6L46_11910	COG0312	modulator of DNA gyrase
I6L46_11915	COG0312	modulator of DNA gyrase
I6L46_11920	COG2888	peptidyl-tyrosine sulfation
I6L46_11925	COG0495	leucyl-tRNA aminoacylation
I6L46_11940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L46_11945	COG0799	negative regulation of ribosome biogenesis
I6L46_11950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L46_11955	COG0768	penicillin binding
I6L46_11960	COG0772	Belongs to the SEDS family
I6L46_11965	COG2951	lytic endotransglycosylase activity
I6L46_11970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L46_11975	COG1686	Belongs to the peptidase S11 family
I6L46_11980	COG2921	Belongs to the UPF0250 family
I6L46_11985	COG0321	lipoyl(octanoyl) transferase activity
I6L46_11990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6L46_12010	COG3139	Protein of unknown function (DUF1315)
I6L46_12015	COG0252	asparaginase activity
I6L46_12020	COG0786	glutamate:sodium symporter activity
I6L46_12035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L46_12040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L46_12045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6L46_12060	COG3610	response to peptide
I6L46_12065	COG2966	Psort location CytoplasmicMembrane, score
I6L46_12075	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6L46_12090	COG2897	thiosulfate sulfurtransferase activity
I6L46_12095	COG2066	Belongs to the glutaminase family
I6L46_12100	COG3171	Protein conserved in bacteria
I6L46_12105	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L46_12110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L46_12115	COG2200	EAL domain
I6L46_12120	COG1090	epimerase
I6L46_12125	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6L46_12130	COG4181	ATPase activity
I6L46_12135	COG2755	lipolytic protein G-D-S-L family
I6L46_12140	COG0784	Response regulator, receiver
I6L46_12140	COG0835	chemotaxis
I6L46_12185	COG3397	chitin binding
I6L46_12205	COG5002	protein histidine kinase activity
I6L46_12205	COG0784	Response regulator, receiver
I6L46_12205	COG2205	protein histidine kinase activity
I6L46_12215	COG3655	Transcriptional regulator
I6L46_12225	COG2814	Major facilitator Superfamily
I6L46_12245	COG0739	heme binding
I6L46_12255	COG3501	Rhs element vgr protein
I6L46_12265	COG0697	spore germination
I6L46_12270	COG0840	transmembrane signaling receptor activity
I6L46_12280	COG0300	oxidoreductase activity
I6L46_12305	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6L46_12345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L46_12350	COG0826	peptidase U32
I6L46_12355	COG1280	lysine exporter protein (LysE YggA)
I6L46_12365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L46_12375	COG0745	RESPONSE REGULATOR receiver
I6L46_12385	COG0643	Histidine kinase
I6L46_12385	COG2198	Histidine kinase
I6L46_12395	COG0835	chemotaxis
I6L46_12400	COG0840	transmembrane signaling receptor activity
I6L46_12410	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6L46_12415	COG2201	protein-glutamate methylesterase activity
I6L46_12420	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L46_12435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L46_12450	COG1047	Peptidyl-prolyl cis-trans
I6L46_12455	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6L46_12465	COG0784	Response regulator, receiver
I6L46_12465	COG0835	chemotaxis
I6L46_12470	COG0429	hydrolase of the alpha beta-hydrolase fold
I6L46_12475	COG4251	negative regulation of phosphorylation
I6L46_12475	COG3706	GGDEF domain
I6L46_12475	COG2203	Gaf domain
I6L46_12475	COG5001	Diguanylate cyclase
I6L46_12480	COG3089	Belongs to the UPF0270 family
I6L46_12485	COG3954	Phosphoribulokinase
I6L46_12500	COG1765	OsmC-like protein
I6L46_12540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L46_12545	COG2313	pseudouridylate synthase activity
I6L46_12555	COG1858	cytochrome C peroxidase
I6L46_12580	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6L46_12600	COG2985	domain, Protein
I6L46_12600	COG0569	domain protein
I6L46_12605	COG1272	protein, Hemolysin III
I6L46_12610	COG0076	glutamate decarboxylase activity
I6L46_12615	COG2917	probably involved in intracellular septation
I6L46_12620	COG2350	Protein conserved in bacteria
I6L46_12630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6L46_12635	COG1381	Involved in DNA repair and RecF pathway recombination
I6L46_12650	COG0681	Belongs to the peptidase S26 family
I6L46_12655	COG0481	GTPase activity
I6L46_12665	COG3026	antisigma factor binding
I6L46_12670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6L46_12675	COG1595	DNA-templated transcription, initiation
I6L46_12680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6L46_12690	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6L46_12695	COG0354	folic acid binding
I6L46_12735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L46_12740	COG0191	fructose-bisphosphate aldolase activity
I6L46_12745	COG0126	phosphoglycerate kinase activity
I6L46_12750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L46_12755	COG1940	carbohydrate kinase activity
I6L46_12760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6L46_12765	COG2816	NAD+ diphosphatase activity
I6L46_12775	COG4991	sh3 domain protein
I6L46_12780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L46_12790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6L46_12815	COG0745	RESPONSE REGULATOR receiver
I6L46_12875	COG1858	cytochrome C peroxidase
I6L46_12880	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6L46_12890	COG2199	diguanylate cyclase activity
I6L46_12890	COG2203	Gaf domain
I6L46_12895	COG0513	Belongs to the DEAD box helicase family
I6L46_12925	COG0154	amidase activity
I6L46_12930	COG2957	Belongs to the agmatine deiminase family
I6L46_12945	COG1902	pentaerythritol trinitrate reductase activity
I6L46_12960	COG1238	metal cluster binding
I6L46_12965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6L46_12970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6L46_12975	COG0585	pseudouridine synthase activity
I6L46_12985	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6L46_12990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6L46_12995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6L46_13005	COG1376	ErfK ybiS ycfS ynhG family protein
I6L46_13010	COG0668	transmembrane transport
I6L46_13020	COG2731	YhcH YjgK YiaL family protein
I6L46_13030	COG1794	racemase activity, acting on amino acids and derivatives
I6L46_13045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L46_13065	COG0488	(ABC) transporter
I6L46_13075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6L46_13125	COG0210	DNA helicase
I6L46_13135	COG0148	phosphopyruvate hydratase activity
I6L46_13140	COG0504	CTP synthase activity
I6L46_13145	COG3956	TIGRFAM MazG family protein
I6L46_13150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L46_13155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L46_13165	COG4807	Protein conserved in bacteria
I6L46_13170	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6L46_13175	COG0783	Belongs to the Dps family
I6L46_13180	COG1151	hydroxylamine reductase activity
I6L46_13185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L46_13190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L46_13195	COG0671	phosphoesterase, PA-phosphatase related
I6L46_13200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L46_13205	COG0163	prenyltransferase activity
I6L46_13220	COG1131	(ABC) transporter
I6L46_13225	COG0842	Transport permease protein
I6L46_13250	COG1823	symporter activity
I6L46_13255	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6L46_13260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6L46_13265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6L46_13275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L46_13280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6L46_13285	COG1489	DNA binding
I6L46_13295	COG1643	Atp-dependent helicase
I6L46_13300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L46_13305	COG0346	lactoylglutathione lyase activity
I6L46_13315	COG2076	Multidrug Resistance protein
I6L46_13320	COG2076	Multidrug Resistance protein
I6L46_13330	COG3437	response regulator, receiver
I6L46_13330	COG0784	Response regulator, receiver
I6L46_13335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6L46_13350	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6L46_13365	COG1136	(ABC) transporter
I6L46_13385	COG0840	transmembrane signaling receptor activity
I6L46_13405	COG0529	Catalyzes the synthesis of activated sulfate
I6L46_13410	COG3273	potassium ion transport
I6L46_13410	COG0471	metal ion transport
I6L46_13415	COG2895	sulfate adenylyltransferase (ATP) activity
I6L46_13420	COG0175	sulfate reduction
I6L46_13425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6L46_13425	COG1648	precorrin-2 dehydrogenase activity
I6L46_13430	COG0330	HflC and HflK could
I6L46_13435	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6L46_13440	COG0840	transmembrane signaling receptor activity
I6L46_13445	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6L46_13450	COG0676	glucose-6-phosphate 1-epimerase activity
I6L46_13455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6L46_13460	COG1640	4-alpha-glucanotransferase
I6L46_13465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L46_13515	COG0561	phosphatase activity
I6L46_13530	COG0733	neurotransmitter:sodium symporter activity
I6L46_13540	COG0733	neurotransmitter:sodium symporter activity
I6L46_13605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6L46_13610	COG2885	chlorophyll binding
I6L46_13615	COG0823	Involved in the tonB-independent uptake of proteins
I6L46_13630	COG0811	peptide transport
I6L46_13635	COG0824	Thioesterase
I6L46_13640	COG3790	cyd operon protein YbgE
I6L46_13645	COG4890	Cyd operon protein YbgT
I6L46_13650	COG1294	oxidase, subunit
I6L46_13660	COG2255	four-way junction helicase activity
I6L46_13665	COG0632	four-way junction helicase activity
I6L46_13670	COG0840	transmembrane signaling receptor activity
I6L46_13680	COG2771	luxR family
I6L46_13695	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
I6L46_13700	COG2203	Gaf domain
I6L46_13700	COG3706	GGDEF domain
I6L46_13700	COG4251	negative regulation of phosphorylation
I6L46_13700	COG5001	Diguanylate cyclase
I6L46_13710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6L46_13720	COG2995	paraquat-inducible protein a
I6L46_13725	COG3008	intermembrane lipid transfer
I6L46_13725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L46_13735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L46_13740	COG0442	prolyl-tRNA aminoacylation
I6L46_13745	COG4221	oxidoreductase activity
I6L46_13760	COG1024	Enoyl-CoA hydratase
I6L46_13770	COG0110	maltose O-acetyltransferase activity
I6L46_13780	COG4166	transmembrane transport
I6L46_13790	COG0840	transmembrane signaling receptor activity
I6L46_13795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L46_13800	COG0735	belongs to the Fur family
I6L46_13825	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L46_13830	COG0513	Belongs to the DEAD box helicase family
I6L46_13835	COG2153	protein acetylation
I6L46_13845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L46_13850	COG0557	exoribonuclease II activity
I6L46_13855	COG3706	GGDEF domain
I6L46_13865	COG3240	lipase activity
I6L46_13870	COG3111	PFAM Bacterial OB fold (BOF) protein
I6L46_13880	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
I6L46_13885	COG1194	a g-specific adenine glycosylase
I6L46_13890	COG0617	tRNA 3'-terminal CCA addition
I6L46_13910	COG3068	Protein conserved in bacteria
I6L46_13920	COG0739	heme binding
I6L46_13940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6L46_13945	COG1121	(ABC) transporter
I6L46_13950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L46_13955	COG0583	DNA-binding transcription factor activity
I6L46_13960	COG0697	spore germination
I6L46_13965	COG1573	uracil-dna glycosylase
I6L46_13980	COG2827	Endonuclease containing a URI domain
I6L46_13995	COG1842	Phage shock protein A
I6L46_14000	COG0204	Acyl-transferase
I6L46_14020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L46_14025	COG0583	DNA-binding transcription factor activity
I6L46_14065	COG3104	oligopeptide transport
I6L46_14075	COG1192	Involved in chromosome partitioning
I6L46_14085	COG0187	DNA topoisomerase II activity
I6L46_14090	COG3150	esterase
I6L46_14100	COG3151	Protein conserved in bacteria
I6L46_14105	COG0494	nUDIX hydrolase
I6L46_14110	COG1538	Outer membrane efflux protein
I6L46_14115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6L46_14115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6L46_14120	COG1560	Kdo2-lipid A biosynthetic process
I6L46_14125	COG2213	PTS system mannitol-specific
I6L46_14125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_14130	COG0246	Mannitol dehydrogenase
I6L46_14135	COG3722	fumarate hydratase activity
I6L46_14140	COG3263	regulation of cellular component size
I6L46_14145	COG0484	heat shock protein binding
I6L46_14165	COG1671	Belongs to the UPF0178 family
I6L46_14170	COG1988	membrane-bound metal-dependent
I6L46_14175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L46_14180	COG0513	Belongs to the DEAD box helicase family
I6L46_14200	COG1575	Belongs to the MenA family. Type 1 subfamily
I6L46_14205	COG1169	isochorismate synthase
I6L46_14210	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6L46_14215	COG0596	Alpha beta hydrolase
I6L46_14220	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6L46_14225	COG1441	menaquinone biosynthetic process
I6L46_14230	COG0318	PFAM AMP-dependent synthetase and ligase
I6L46_14245	COG3539	Fimbrial protein
I6L46_14250	COG3121	Chaperone
I6L46_14255	COG3188	usher protein
I6L46_14275	COG3291	Pkd domain containing protein
I6L46_14280	COG2949	membrane
I6L46_14285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L46_14295	COG0784	Response regulator, receiver
I6L46_14295	COG0835	chemotaxis
I6L46_14300	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_14305	COG1444	tRNA N-acetyltransferase activity
I6L46_14330	COG1803	Methylglyoxal synthase
I6L46_14335	COG1979	alcohol dehydrogenase
I6L46_14350	COG4221	oxidoreductase activity
I6L46_14390	COG1368	sulfuric ester hydrolase activity
I6L46_14395	COG1522	sequence-specific DNA binding
I6L46_14405	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L46_14415	COG1058	Belongs to the CinA family
I6L46_14415	COG1546	Belongs to the CinA family
I6L46_14425	COG0561	phosphatase activity
I6L46_14435	COG2926	Belongs to the UPF0265 family
I6L46_14470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L46_14475	COG0564	pseudouridine synthase activity
I6L46_14485	COG0110	maltose O-acetyltransferase activity
I6L46_14490	COG0366	Alpha amylase catalytic
I6L46_14495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L46_14495	COG1263	PTS System
I6L46_14510	COG2217	Heavy metal translocating P-type atpase
I6L46_14515	COG0252	asparaginase activity
I6L46_14520	COG1253	flavin adenine dinucleotide binding
I6L46_14525	COG0586	Pfam SNARE associated Golgi protein
I6L46_14530	COG1686	Belongs to the peptidase S11 family
I6L46_14565	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6L46_14570	COG0527	aspartate kinase activity
I6L46_14575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L46_14585	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L46_14590	COG1546	Belongs to the CinA family
I6L46_14595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L46_14600	COG4667	esterase of the alpha-beta hydrolase superfamily
I6L46_14610	COG1346	cytolysis
I6L46_14615	COG1380	Effector of murein hydrolase LrgA
I6L46_14620	COG0583	DNA-binding transcription factor activity
I6L46_14630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L46_14635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L46_14645	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L46_14650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L46_14660	COG0137	argininosuccinate synthase activity
I6L46_14665	COG0165	Argininosuccinate lyase
I6L46_14675	COG3314	Sporulation integral membrane protein YlbJ
I6L46_14700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L46_14705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6L46_14720	COG0477	Major facilitator Superfamily
I6L46_14735	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_14740	COG0523	cobalamin synthesis protein
I6L46_14750	COG2200	EAL domain
I6L46_14755	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6L46_14760	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6L46_14765	COG0840	transmembrane signaling receptor activity
I6L46_14775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L46_14780	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L46_14785	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6L46_14790	COG2186	Transcriptional regulator
I6L46_14815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L46_14820	COG1459	type II secretion system
I6L46_14825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6L46_14835	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
I6L46_14840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6L46_14845	COG0494	nUDIX hydrolase
I6L46_14850	COG0653	protein targeting
I6L46_14860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6L46_14865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6L46_14870	COG0849	cell division
I6L46_14880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L46_14885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L46_14890	COG0772	Belongs to the SEDS family
I6L46_14895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L46_14900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L46_14905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L46_14915	COG0768	penicillin binding
I6L46_14920	COG3116	cell division
I6L46_14925	COG0275	rRNA processing
I6L46_14930	COG2001	Belongs to the MraZ family
I6L46_14935	COG1388	LysM domain
I6L46_14935	COG0741	lytic transglycosylase activity
I6L46_14950	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6L46_14955	COG1191	sigma factor activity
I6L46_14980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6L46_15000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6L46_15005	COG1256	bacterial-type flagellum assembly
I6L46_15005	COG4786	Flagellar basal body rod
I6L46_15015	COG1706	bacterial-type flagellum-dependent cell motility
I6L46_15020	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6L46_15025	COG4786	Flagellar basal body rod
I6L46_15030	COG4787	bacterial-type flagellum-dependent cell motility
I6L46_15035	COG1749	Flagellar hook protein flgE
I6L46_15050	COG1815	bacterial-type flagellum-dependent cell motility
I6L46_15055	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6L46_15085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6L46_15095	COG1677	Flagellar hook-basal body complex protein FliE
I6L46_15120	COG1987	bacterial-type flagellum assembly
I6L46_15145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6L46_15150	COG3107	peptidoglycan biosynthetic process
I6L46_15155	COG0792	nuclease activity
I6L46_15160	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6L46_15165	COG2823	Periplasmic or secreted lipoprotein
I6L46_15170	COG2969	positive regulation of protein catabolic process
I6L46_15175	COG0625	glutathione transferase activity
I6L46_15180	COG2857	Cytochrome c1
I6L46_15185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6L46_15190	COG0723	plastoquinol--plastocyanin reductase activity
I6L46_15195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L46_15200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L46_15205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6L46_15215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L46_15220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L46_15250	COG3964	amidohydrolase
I6L46_15265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_15265	COG3711	transcriptional antiterminator
I6L46_15270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_15275	COG1660	Displays ATPase and GTPase activities
I6L46_15280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_15295	COG1137	ATPase activity
I6L46_15300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6L46_15305	COG3117	lipopolysaccharide transmembrane transporter activity
I6L46_15310	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6L46_15315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6L46_15315	COG0517	IMP dehydrogenase activity
I6L46_15320	COG1127	ABC transporter
I6L46_15325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6L46_15330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6L46_15335	COG2854	intermembrane phospholipid transfer
I6L46_15345	COG5007	Belongs to the BolA IbaG family
I6L46_15350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L46_15355	COG0312	modulator of DNA gyrase
I6L46_15360	COG3028	Belongs to the UPF0307 family
I6L46_15365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L46_15385	COG1011	Hydrolase
I6L46_15400	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6L46_15405	COG0019	diaminopimelate decarboxylase activity
I6L46_15415	COG1965	Belongs to the frataxin family
I6L46_15420	COG0400	carboxylic ester hydrolase activity
I6L46_15425	COG3072	Adenylate cyclase
I6L46_15430	COG0181	hydroxymethylbilane synthase activity
I6L46_15440	COG2959	enzyme of heme biosynthesis
I6L46_15455	COG1494	fructose-1,6-bisphosphatase
I6L46_15515	COG0795	lipopolysaccharide-transporting ATPase activity
I6L46_15520	COG0795	lipopolysaccharide-transporting ATPase activity
I6L46_15525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6L46_15530	COG2927	DNA polymerase III (CHI subunit)
I6L46_15560	COG0753	catalase activity
I6L46_15585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L46_15590	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6L46_15595	COG5380	lipid catabolic process
I6L46_15615	COG4533	DNA binding
I6L46_15625	COG2873	o-acetylhomoserine
I6L46_15655	COG3842	ATPase activity
I6L46_15665	COG1175	transmembrane transport
I6L46_15720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L46_15725	COG1074	ATP-dependent DNA helicase activity
I6L46_15730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6L46_15735	COG2259	Doxx family
I6L46_15740	COG1741	Belongs to the pirin family
I6L46_15750	COG0583	DNA-binding transcription factor activity
I6L46_15775	COG3706	GGDEF domain
I6L46_15780	COG4771	TonB-dependent receptor
I6L46_15815	COG0203	ribosomal protein L17
I6L46_15820	COG0202	RNA polymerase activity
I6L46_15825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L46_15830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L46_15835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L46_15840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6L46_15845	COG0201	protein transport
I6L46_15850	COG0200	Binds to the 23S rRNA
I6L46_15855	COG1841	ribosomal large subunit assembly
I6L46_15860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L46_15865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6L46_15870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L46_15875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L46_15880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L46_15885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L46_15890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L46_15895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L46_15900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L46_15905	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L46_15910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L46_15915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L46_15920	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L46_15925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6L46_15930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L46_15935	COG0089	rRNA binding
I6L46_15940	COG0088	Forms part of the polypeptide exit tunnel
I6L46_15945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L46_15950	COG0051	transcription antitermination factor activity, RNA binding
I6L46_15970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L46_15975	COG2183	response to ionizing radiation
I6L46_16000	COG0596	Alpha beta hydrolase
I6L46_16005	COG1040	competence protein
I6L46_16010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6L46_16010	COG0316	Belongs to the HesB IscA family
I6L46_16015	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L46_16020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6L46_16025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L46_16030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6L46_16035	COG4942	peptidase
I6L46_16045	COG1609	Transcriptional regulator
I6L46_16050	COG0800	Aldolase
I6L46_16055	COG0129	dihydroxy-acid dehydratase activity
I6L46_16060	COG3265	gluconokinase activity
I6L46_16065	COG2610	gluconate transmembrane transporter activity
I6L46_16070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L46_16075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L46_16085	COG0456	acetyltransferase
I6L46_16090	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6L46_16095	COG1490	D-aminoacyl-tRNA deacylase activity
I6L46_16100	COG1295	ribonuclease BN
I6L46_16105	COG0281	malic enzyme
I6L46_16110	COG0814	amino acid
I6L46_16115	COG0702	epimerase
I6L46_16125	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L46_16130	COG0254	rRNA binding
I6L46_16145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6L46_16150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6L46_16160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6L46_16170	COG0514	ATP-dependent DNA helicase (RecQ)
I6L46_16175	COG2050	protein possibly involved in aromatic compounds catabolism
I6L46_16190	COG2258	MOSC domain
I6L46_16195	COG1177	transmembrane transport
I6L46_16200	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L46_16205	COG3842	ATPase activity
I6L46_16225	COG0174	glutamine synthetase
I6L46_16245	COG3045	CreA protein
I6L46_16250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6L46_16255	COG0443	Heat shock 70 kDa protein
I6L46_16270	COG0366	Alpha amylase catalytic
I6L46_16285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L46_16295	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6L46_16300	COG1129	ABC transporter
I6L46_16310	COG3250	beta-galactosidase activity
I6L46_16315	COG1609	Transcriptional regulator
I6L46_16320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L46_16325	COG1085	galactose-1-phosphate uridylyltransferase
I6L46_16330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L46_16335	COG2017	converts alpha-aldose to the beta-anomer
I6L46_16340	COG1968	undecaprenyl-diphosphatase activity
I6L46_16350	COG1595	DNA-templated transcription, initiation
I6L46_16360	COG0018	arginyl-trna synthetase
I6L46_16370	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6L46_16375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6L46_16380	COG2239	Acts as a magnesium transporter
I6L46_16390	COG0737	Belongs to the 5'-nucleotidase family
I6L46_16395	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L46_16400	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L46_16405	COG3845	ABC transporter
I6L46_16410	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L46_16425	COG0210	DNA helicase
I6L46_16485	COG1280	lysine exporter protein (LysE YggA)
I6L46_16520	COG3306	glycosyltransferase involved in LPS biosynthesis
I6L46_16525	COG3307	-O-antigen
I6L46_16540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L46_16555	COG1063	alcohol dehydrogenase
I6L46_16560	COG3245	cytochrome
I6L46_16575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L46_16580	COG2166	iron-sulfur cluster assembly
I6L46_16585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6L46_16615	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L46_16620	COG4206	TonB-dependent receptor
I6L46_16625	COG0583	DNA-binding transcription factor activity
I6L46_16640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L46_16645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6L46_16650	COG2223	nitrite transmembrane transporter activity
I6L46_16655	COG3279	Response regulator of the LytR AlgR family
I6L46_16660	COG3275	phosphorelay sensor kinase activity
I6L46_16665	COG2081	HI0933 family
I6L46_16670	COG1528	Iron-storage protein
I6L46_16675	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6L46_16680	COG0589	response to stress
I6L46_16720	COG3642	lipopolysaccharide core region biosynthetic process
I6L46_16725	COG0859	PFAM glycosyl transferase family 9
I6L46_16730	COG0194	GDP metabolic process
I6L46_16735	COG1758	RNA polymerase activity
I6L46_16740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6L46_16745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L46_16755	COG2267	carboxylic ester hydrolase activity
I6L46_16760	COG0561	phosphatase activity
I6L46_16790	COG1309	transcriptional regulator
I6L46_16795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6L46_16800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6L46_16805	COG4191	Histidine kinase
I6L46_16805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_16810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L46_16830	COG2205	protein histidine kinase activity
I6L46_16835	COG0745	RESPONSE REGULATOR receiver
I6L46_16840	COG2814	Major facilitator Superfamily
I6L46_16855	COG3977	Valine--pyruvate aminotransferase
I6L46_16860	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L46_16865	COG0071	Belongs to the small heat shock protein (HSP20) family
I6L46_16890	COG0592	DNA-directed DNA polymerase activity
I6L46_16895	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L46_16910	COG1126	abc transporter atp-binding protein
I6L46_16915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L46_16920	COG0594	ribonuclease P activity
I6L46_16925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L46_16930	COG0706	membrane insertase activity
I6L46_16935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L46_16940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L46_16945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6L46_16950	COG1120	ATPase activity
I6L46_16955	COG4615	Cyclic peptide transporter
I6L46_16965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6L46_16970	COG0445	tRNA wobble uridine modification
I6L46_16975	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L46_16980	COG1192	Involved in chromosome partitioning
I6L46_16985	COG1475	DNA binding
I6L46_16995	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L46_17005	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L46_17010	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L46_17015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L46_17020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L46_17025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L46_17030	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L46_17035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L46_17040	COG4452	Inner membrane protein CreD
I6L46_17055	COG2205	protein histidine kinase activity
I6L46_17060	COG0745	RESPONSE REGULATOR receiver
I6L46_17065	COG1349	DNA-binding transcription factor activity
I6L46_17070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L46_17075	COG2771	luxR family
I6L46_17085	COG0811	peptide transport
I6L46_17090	COG0811	peptide transport
I6L46_17095	COG0848	biopolymer transport protein
I6L46_17100	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6L46_17135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6L46_17140	COG0402	S-adenosylhomocysteine deaminase activity
I6L46_17145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6L46_17150	COG2226	methyltransferase
I6L46_17155	COG3165	ubiquinone biosynthetic process from chorismate
I6L46_17160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6L46_17165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L46_17170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L46_17175	COG0805	protein transport
I6L46_17180	COG0084	hydrolase, TatD family'
I6L46_17190	COG3397	chitin binding
I6L46_17195	COG3469	chitinase activity
I6L46_17210	COG0742	ribosomal rna small subunit methyltransferase
I6L46_17220	COG0248	Ppx GppA phosphatase
I6L46_17225	COG0513	Belongs to the DEAD box helicase family
I6L46_17230	COG3118	belongs to the thioredoxin family
I6L46_17245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6L46_17255	COG5001	Diguanylate cyclase
I6L46_17260	COG2960	long-chain fatty acid transporting porin activity
I6L46_17275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L46_17305	COG1609	Transcriptional regulator
I6L46_17335	COG2199	diguanylate cyclase activity
I6L46_17335	COG2200	EAL domain
I6L46_17335	COG2202	Pas domain
I6L46_17350	COG0751	glycine-tRNA ligase activity
I6L46_17355	COG0752	glycyl-tRNA synthetase alpha subunit
I6L46_17360	COG2818	Glycosylase
I6L46_17365	COG2885	chlorophyll binding
I6L46_17375	COG0425	Belongs to the sulfur carrier protein TusA family
I6L46_17400	COG0183	Belongs to the thiolase family
I6L46_17405	COG1024	Enoyl-CoA hydratase
I6L46_17405	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L46_17410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6L46_17415	COG0006	proline dipeptidase activity
I6L46_17420	COG1739	Uncharacterized protein family UPF0029
I6L46_17425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L46_17430	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6L46_17465	COG1042	CoA-binding domain protein
I6L46_17465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L46_17465	COG0045	succinate-CoA ligase (ADP-forming) activity
I6L46_17485	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L46_17490	COG0166	Belongs to the GPI family
I6L46_17495	COG0668	transmembrane transport
I6L46_17500	COG1309	transcriptional regulator
I6L46_17505	COG0756	dUTP diphosphatase activity
I6L46_17510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L46_17515	COG2003	Belongs to the UPF0758 family
I6L46_17520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L46_17525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L46_17535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L46_17540	COG2990	Protein conserved in bacteria
I6L46_17545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L46_17550	COG0859	PFAM glycosyl transferase family 9
I6L46_17555	COG0463	Glycosyl transferase, family 2
I6L46_17560	COG0859	PFAM glycosyl transferase family 9
I6L46_17565	COG1519	Transferase
I6L46_17580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_17585	COG1609	Transcriptional regulator
I6L46_17590	COG0604	alcohol dehydrogenase
I6L46_17610	COG3161	chorismate lyase activity
I6L46_17615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6L46_17620	COG2937	Belongs to the GPAT DAPAT family
I6L46_17625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L46_17640	COG0534	Mate efflux family protein
I6L46_17645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6L46_17650	COG2205	protein histidine kinase activity
I6L46_17655	COG0745	RESPONSE REGULATOR receiver
I6L46_17665	COG1045	serine acetyltransferase
I6L46_17675	COG3074	FtsZ-dependent cytokinesis
I6L46_17680	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6L46_17685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L46_17685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L46_17690	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6L46_17725	COG1609	Transcriptional regulator
I6L46_17730	COG3250	beta-galactosidase activity
I6L46_17735	COG2731	YhcH YjgK YiaL family protein
I6L46_17740	COG0531	amino acid
I6L46_17745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L46_17750	COG0531	amino acid
I6L46_17755	COG0385	Bile acid
I6L46_17760	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6L46_17780	COG0583	DNA-binding transcription factor activity
I6L46_17785	COG1561	YicC-like family, N-terminal region
I6L46_17790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6L46_17795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L46_17810	COG5001	Diguanylate cyclase
I6L46_17810	COG3706	GGDEF domain
I6L46_17810	COG2203	Gaf domain
I6L46_17810	COG4251	negative regulation of phosphorylation
I6L46_17815	COG3084	Protein conserved in bacteria
I6L46_17825	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6L46_17830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L46_17840	COG1335	isochorismatase
I6L46_17850	COG1683	Conserved Protein
I6L46_17855	COG0204	Acyl-transferase
I6L46_17860	COG0204	Acyl-transferase
I6L46_17865	COG0606	chelatase, subunit chli
I6L46_17875	COG3978	acetolactate synthase activity
I6L46_17885	COG0129	dihydroxy-acid dehydratase activity
I6L46_17900	COG2391	methyltransferase activity
I6L46_17905	COG0840	transmembrane signaling receptor activity
I6L46_17910	COG2962	Rard protein
I6L46_17920	COG1012	belongs to the aldehyde dehydrogenase family
I6L46_17925	COG1396	sequence-specific DNA binding
I6L46_17930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L46_17940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6L46_17940	COG0519	Catalyzes the synthesis of GMP from XMP
I6L46_17950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6L46_17970	COG1322	Protein conserved in bacteria
I6L46_17975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L46_17980	COG2204	response regulator
I6L46_17995	COG0174	glutamine synthetase
I6L46_18000	COG1217	gtp-binding protein TYPA
I6L46_18005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L46_18010	COG0569	domain protein
I6L46_18015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L46_18015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L46_18020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L46_18025	COG0242	peptide deformylase activity
I6L46_18030	COG1652	LysM domain
I6L46_18035	COG0758	DNA mediated transformation
I6L46_18040	COG2922	Belongs to the Smg family
I6L46_18045	COG0551	DNA topoisomerase type I activity
I6L46_18055	COG0009	L-threonylcarbamoyladenylate synthase
I6L46_18060	COG0408	coproporphyrinogen oxidase activity
I6L46_18065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L46_18075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L46_18085	COG3078	GTPase activator activity
I6L46_18095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L46_18125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L46_18130	COG1288	antiporter activity
I6L46_18135	COG1438	arginine binding
I6L46_18140	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
I6L46_18145	COG0540	Belongs to the ATCase OTCase family
I6L46_18165	COG0583	DNA-binding transcription factor activity
I6L46_18185	COG2207	Transcriptional regulator
I6L46_18190	COG1979	alcohol dehydrogenase
I6L46_18195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6L46_18200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6L46_18210	COG2964	Protein conserved in bacteria
I6L46_18215	COG3681	Belongs to the UPF0597 family
I6L46_18225	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6L46_18230	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6L46_18235	COG0564	pseudouridine synthase activity
I6L46_18245	COG0542	response to heat
I6L46_18250	COG2502	aspartate--ammonia ligase
I6L46_18255	COG1522	sequence-specific DNA binding
I6L46_18265	COG5413	integral membrane protein
I6L46_18270	COG0516	GMP reductase activity
I6L46_18270	COG0517	IMP dehydrogenase activity
I6L46_18275	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_18290	COG2205	protein histidine kinase activity
I6L46_18300	COG2204	response regulator
I6L46_18345	COG0243	molybdopterin cofactor binding
I6L46_18350	COG3005	denitrification pathway
I6L46_18355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_18355	COG4191	Histidine kinase
I6L46_18385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L46_18390	COG0569	domain protein
I6L46_18395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L46_18420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L46_18435	COG0250	Participates in transcription elongation, termination and antitermination
I6L46_18440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L46_18445	COG0081	regulation of translation
I6L46_18450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L46_18455	COG0222	ribosome binding
I6L46_18460	COG0085	RNA polymerase activity
I6L46_18465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L46_18470	COG2964	Protein conserved in bacteria
I6L46_18480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6L46_18485	COG2923	Belongs to the DsrF TusC family
I6L46_18490	COG2168	tRNA wobble position uridine thiolation
I6L46_18495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L46_18500	COG0049	tRNA binding
I6L46_18505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L46_18510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L46_18515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L46_18565	COG3714	YhhN family
I6L46_18590	COG1301	dicarboxylic acid transport
I6L46_18600	COG2095	MarC family integral membrane protein
I6L46_18610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6L46_18620	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6L46_18630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L46_18645	COG1770	oligopeptidase
I6L46_18660	COG4221	oxidoreductase activity
I6L46_18665	COG0583	DNA-binding transcription factor activity
I6L46_18670	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L46_18695	COG0742	ribosomal rna small subunit methyltransferase
I6L46_18700	COG0552	protein localization to endoplasmic reticulum
I6L46_18705	COG2884	Cell division ATP-binding protein ftsE
I6L46_18710	COG2177	Part of the ABC transporter FtsEX involved in
I6L46_18720	COG0288	reversible hydration of carbon dioxide
I6L46_18725	COG2188	Transcriptional regulator
I6L46_18730	COG1228	amidohydrolase
I6L46_18735	COG0010	Belongs to the arginase family
I6L46_18740	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6L46_18745	COG2986	histidine ammonia-lyase
I6L46_18750	COG0387	Pfam Sodium calcium exchanger
I6L46_18755	COG2200	EAL domain
I6L46_18760	COG2200	EAL domain
I6L46_18760	COG2199	diguanylate cyclase activity
I6L46_18800	COG2842	Transposition protein
I6L46_18810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L46_18815	COG1459	type II secretion system
I6L46_18830	COG4969	Belongs to the N-Me-Phe pilin family
I6L46_18835	COG4968	Prepilin-type N-terminal cleavage methylation domain
I6L46_18860	COG1077	Cell shape determining protein MreB Mrl
I6L46_18865	COG1792	Involved in formation and maintenance of cell shape
I6L46_18870	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6L46_18875	COG0424	maF-like protein
I6L46_18880	COG1530	ribonuclease E activity
I6L46_18885	COG3164	Protein of unknown function
I6L46_18895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L46_18900	COG0312	modulator of DNA gyrase
I6L46_18915	COG0477	Major facilitator Superfamily
I6L46_18960	COG0189	ligase activity
I6L46_18970	COG0642	Histidine kinase
I6L46_18975	COG0745	RESPONSE REGULATOR receiver
I6L46_18995	COG3766	membrane
I6L46_19005	COG0754	glutathionylspermidine amidase activity
I6L46_19010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6L46_19015	COG0352	thiamine-phosphate diphosphorylase activity
I6L46_19020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6L46_19030	COG2022	thiamine diphosphate biosynthetic process
I6L46_19035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6L46_19055	COG0110	maltose O-acetyltransferase activity
I6L46_19065	COG3706	GGDEF domain
I6L46_19070	COG0814	amino acid
I6L46_19075	COG3932	Exopolysaccharide synthesis, ExoD
I6L46_19085	COG3706	GGDEF domain
I6L46_19090	COG0004	ammonium transporteR
I6L46_19095	COG3133	Outer membrane lipoprotein
I6L46_19100	COG0456	acetyltransferase
I6L46_19120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L46_19125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L46_19140	COG0494	nUDIX hydrolase
I6L46_19145	COG0628	permease
I6L46_19155	COG2957	Belongs to the agmatine deiminase family
I6L46_19160	COG0583	DNA-binding transcription factor activity
I6L46_19165	COG3284	Transcriptional regulator
I6L46_19175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L46_19175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6L46_19175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L46_19180	COG1461	Dihydroxyacetone kinase
I6L46_19185	COG2376	Dihydroxyacetone kinase
I6L46_19190	COG2252	PERMEase
I6L46_19195	COG1278	Cold shock
I6L46_19205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6L46_19220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L46_19235	COG0840	transmembrane signaling receptor activity
I6L46_19260	COG3135	benzoate transporter
I6L46_19265	COG1396	sequence-specific DNA binding
I6L46_19305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L46_19305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6L46_19320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6L46_19325	COG0038	chloride channel
I6L46_19335	COG0316	Belongs to the HesB IscA family
I6L46_19340	COG1757	Na H antiporter
I6L46_19380	COG0297	glycogen (starch) synthase activity
I6L46_19385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L46_19390	COG2813	Specifically methylates the guanine in position
I6L46_19395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L46_19405	COG3025	triphosphatase activity
I6L46_19410	COG1392	Phosphate transport regulator
I6L46_19415	COG0306	phosphate transporter
I6L46_19420	COG0460	homoserine dehydrogenase
I6L46_19420	COG0527	aspartate kinase activity
I6L46_19425	COG0626	cystathionine gamma-synthase activity
I6L46_19440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L46_19445	COG0814	amino acid
I6L46_19450	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6L46_19455	COG0494	nUDIX hydrolase
I6L46_19460	COG1011	Hydrolase
I6L46_19475	COG0110	maltose O-acetyltransferase activity
I6L46_19480	COG3174	membrane
I6L46_19485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6L46_19495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6L46_19500	COG4208	sulfate ABC transporter
I6L46_19505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6L46_19510	COG0583	DNA-binding transcription factor activity
I6L46_19515	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6L46_19520	COG0765	amino acid transport
I6L46_19535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_19540	COG3397	chitin binding
I6L46_19545	COG0840	transmembrane signaling receptor activity
I6L46_19560	COG0543	2 iron, 2 sulfur cluster binding
I6L46_19560	COG0633	Ferredoxin
I6L46_19585	COG1328	CTP reductase activity
I6L46_19590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L46_19605	COG1448	Aminotransferase
I6L46_19645	COG0513	Belongs to the DEAD box helicase family
I6L46_19655	COG3568	Endonuclease Exonuclease Phosphatase
I6L46_19675	COG3112	Uncharacterised protein family (UPF0231)
I6L46_19680	COG3835	regulator
I6L46_19685	COG2610	gluconate transmembrane transporter activity
I6L46_19690	COG1929	Belongs to the glycerate kinase type-1 family
I6L46_19705	COG0583	DNA-binding transcription factor activity
I6L46_19710	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L46_19720	COG1872	DUF167
I6L46_19725	COG0762	integral membrane protein
I6L46_19730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L46_19735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L46_19750	COG3022	response to hydroperoxide
I6L46_19770	COG0347	Belongs to the P(II) protein family
I6L46_19775	COG1840	ABC-type Fe3 transport system, periplasmic component
I6L46_19785	COG3842	ATPase activity
I6L46_19790	COG2837	iron assimilation
I6L46_19795	COG1438	arginine binding
I6L46_19800	COG1126	abc transporter atp-binding protein
I6L46_19805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L46_19810	COG4215	(ABC) transporter
I6L46_19815	COG4160	amino acid transport
I6L46_19820	COG0039	L-malate dehydrogenase activity
I6L46_19825	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6L46_19830	COG1017	nitric oxide dioxygenase activity
I6L46_19830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L46_19840	COG4536	flavin adenine dinucleotide binding
I6L46_19845	COG4137	Cytochrome C assembly protein
I6L46_19850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L46_19855	COG0228	four-way junction DNA binding
I6L46_19860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L46_19865	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L46_19870	COG0335	large ribosomal subunit rRNA binding
I6L46_19880	COG3066	DNA modification
I6L46_19885	COG1051	belongs to the nudix hydrolase family
I6L46_19895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L46_19900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L46_19905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6L46_19915	COG0583	DNA-binding transcription factor activity
I6L46_19920	COG0640	Transcriptional regulator
I6L46_19925	COG0268	Binds directly to 16S ribosomal RNA
I6L46_19930	COG0728	peptidoglycan biosynthetic process
I6L46_19935	COG0196	riboflavin kinase activity
I6L46_19940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L46_19945	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L46_19950	COG1047	Peptidyl-prolyl cis-trans
I6L46_19955	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6L46_20000	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L46_20000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L46_20015	COG1854	S-ribosylhomocysteine lyase activity
I6L46_20020	COG2165	general secretion pathway protein
I6L46_20025	COG0084	hydrolase, TatD family'
I6L46_20030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6L46_20040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L46_20045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L46_20050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L46_20055	COG0813	purine-nucleoside phosphorylase activity
I6L46_20065	COG0560	Phosphoserine phosphatase
I6L46_20080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6L46_20095	COG0776	regulation of translation
I6L46_20105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L46_20110	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L46_20115	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L46_20120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L46_20125	COG0359	binds to the 23S rRNA
I6L46_20130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6L46_20155	COG1064	alcohol dehydrogenase
I6L46_20160	COG1238	metal cluster binding
I6L46_20165	COG0612	Peptidase, M16
I6L46_20170	COG2918	glutathione biosynthetic process
I6L46_20175	COG1022	Amp-dependent synthetase and ligase
I6L46_20185	COG0456	acetyltransferase
I6L46_20200	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6L46_20210	COG1028	Short-chain dehydrogenase reductase Sdr
I6L46_20225	COG0477	Major facilitator Superfamily
I6L46_20230	COG0583	DNA-binding transcription factor activity
I6L46_20240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L46_20245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6L46_20255	COG0673	inositol 2-dehydrogenase activity
I6L46_20265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L46_20270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L46_20280	COG3036	rescue of stalled ribosome
I6L46_20290	COG0138	bifunctional purine biosynthesis protein purh
I6L46_20295	COG0151	Belongs to the GarS family
I6L46_20315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L46_20325	COG1610	YqeY-like protein
I6L46_20330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6L46_20335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L46_20340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6L46_20345	COG1027	Aspartate ammonia-lyase
I6L46_20350	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6L46_20355	COG0534	Mate efflux family protein
I6L46_20360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L46_20365	COG0459	protein refolding
I6L46_20415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6L46_20420	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6L46_20425	COG1178	ABC-type Fe3 transport system permease component
I6L46_20445	COG0066	3-isopropylmalate dehydratase activity
I6L46_20450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L46_20455	COG0473	3-isopropylmalate dehydrogenase activity
I6L46_20460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6L46_20470	COG0671	phosphoesterase, PA-phosphatase related
I6L46_20485	COG0028	Belongs to the TPP enzyme family
I6L46_20490	COG0440	acetolactate synthase activity
I6L46_20535	COG3311	Transcriptional regulator
I6L46_20580	COG2003	Belongs to the UPF0758 family
I6L46_20630	COG1388	LysM domain
I6L46_20630	COG1470	cell adhesion involved in biofilm formation
I6L46_20680	COG2200	EAL domain
I6L46_20680	COG2771	luxR family