locus-tag	class	description
WP2W18C05_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP2W18C05_00020	COG0592	DNA-directed DNA polymerase activity
WP2W18C05_00040	COG0187	DNA topoisomerase II activity
WP2W18C05_00050	COG2207	Transcriptional regulator
WP2W18C05_00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2W18C05_00070	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18C05_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18C05_00090	COG3977	Valine--pyruvate aminotransferase
WP2W18C05_00120	COG2814	Major facilitator Superfamily
WP2W18C05_00130	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_00140	COG2205	protein histidine kinase activity
WP2W18C05_00180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18C05_00190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_00190	COG4191	Histidine kinase
WP2W18C05_00200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_00210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_00220	COG1309	transcriptional regulator
WP2W18C05_00240	COG0561	phosphatase activity
WP2W18C05_00250	COG2267	carboxylic ester hydrolase activity
WP2W18C05_00270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18C05_00280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18C05_00290	COG1758	RNA polymerase activity
WP2W18C05_00310	COG0859	PFAM glycosyl transferase family 9
WP2W18C05_00320	COG3642	lipopolysaccharide core region biosynthetic process
WP2W18C05_00400	COG0589	response to stress
WP2W18C05_00420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP2W18C05_00430	COG3706	GGDEF domain
WP2W18C05_00440	COG1528	Iron-storage protein
WP2W18C05_00450	COG2081	HI0933 family
WP2W18C05_00460	COG2223	nitrite transmembrane transporter activity
WP2W18C05_00470	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_00500	COG3188	usher protein
WP2W18C05_00550	COG2205	protein histidine kinase activity
WP2W18C05_00550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_00570	COG3275	phosphorelay sensor kinase activity
WP2W18C05_00580	COG3279	Response regulator of the LytR AlgR family
WP2W18C05_00590	COG2223	nitrite transmembrane transporter activity
WP2W18C05_00600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP2W18C05_00610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP2W18C05_00660	COG1609	Transcriptional regulator
WP2W18C05_00670	COG3250	beta-galactosidase activity
WP2W18C05_00680	COG2731	YhcH YjgK YiaL family protein
WP2W18C05_00690	COG0531	amino acid
WP2W18C05_00700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18C05_00710	COG0531	amino acid
WP2W18C05_00720	COG0385	Bile acid
WP2W18C05_00730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2W18C05_00780	COG0583	DNA-binding transcription factor activity
WP2W18C05_00830	COG0210	DNA helicase
WP2W18C05_00850	COG3385	transposase activity
WP2W18C05_00860	COG3385	transposase activity
WP2W18C05_00870	COG1943	Transposase
WP2W18C05_00880	COG0583	DNA-binding transcription factor activity
WP2W18C05_00960	COG0583	DNA-binding transcription factor activity
WP2W18C05_00990	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_01010	COG2962	Rard protein
WP2W18C05_01030	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_01040	COG1396	sequence-specific DNA binding
WP2W18C05_01070	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18C05_01070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18C05_01090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18C05_01130	COG1322	Protein conserved in bacteria
WP2W18C05_01140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18C05_01150	COG0569	domain protein
WP2W18C05_01160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18C05_01160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18C05_01170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP2W18C05_01180	COG0242	peptide deformylase activity
WP2W18C05_01200	COG0758	DNA mediated transformation
WP2W18C05_01210	COG2922	Belongs to the Smg family
WP2W18C05_01220	COG0551	DNA topoisomerase type I activity
WP2W18C05_01230	COG0009	L-threonylcarbamoyladenylate synthase
WP2W18C05_01240	COG0408	coproporphyrinogen oxidase activity
WP2W18C05_01250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP2W18C05_01260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP2W18C05_01280	COG3078	GTPase activator activity
WP2W18C05_01300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2W18C05_01310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2W18C05_01320	COG2204	response regulator
WP2W18C05_01330	COG3852	Histidine kinase
WP2W18C05_01350	COG0174	glutamine synthetase
WP2W18C05_01370	COG1295	ribonuclease BN
WP2W18C05_01380	COG1490	D-aminoacyl-tRNA deacylase activity
WP2W18C05_01410	COG0456	acetyltransferase
WP2W18C05_01430	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP2W18C05_01440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18C05_01450	COG2610	gluconate transmembrane transporter activity
WP2W18C05_01460	COG3265	gluconokinase activity
WP2W18C05_01470	COG0129	dihydroxy-acid dehydratase activity
WP2W18C05_01480	COG0800	Aldolase
WP2W18C05_01510	COG1609	Transcriptional regulator
WP2W18C05_01530	COG4942	peptidase
WP2W18C05_01540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP2W18C05_01550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18C05_01560	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP2W18C05_01570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP2W18C05_01580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP2W18C05_01580	COG0316	Belongs to the HesB IscA family
WP2W18C05_01590	COG1040	competence protein
WP2W18C05_01610	COG0596	Alpha beta hydrolase
WP2W18C05_01640	COG2183	response to ionizing radiation
WP2W18C05_01650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2W18C05_01660	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_01670	COG2205	protein histidine kinase activity
WP2W18C05_01690	COG0051	transcription antitermination factor activity, RNA binding
WP2W18C05_01700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP2W18C05_01710	COG0088	Forms part of the polypeptide exit tunnel
WP2W18C05_01720	COG0089	rRNA binding
WP2W18C05_01730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP2W18C05_01740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP2W18C05_01750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP2W18C05_01760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP2W18C05_01770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP2W18C05_01780	COG0255	Belongs to the universal ribosomal protein uL29 family
WP2W18C05_01790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP2W18C05_01800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP2W18C05_01810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP2W18C05_01820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP2W18C05_01830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP2W18C05_01840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP2W18C05_01850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP2W18C05_01860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP2W18C05_01870	COG1841	ribosomal large subunit assembly
WP2W18C05_01880	COG0200	Binds to the 23S rRNA
WP2W18C05_01890	COG0201	protein transport
WP2W18C05_01900	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP2W18C05_01910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP2W18C05_01920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP2W18C05_01930	COG0202	RNA polymerase activity
WP2W18C05_01940	COG0203	ribosomal protein L17
WP2W18C05_01950	COG2801	Transposase and inactivated derivatives
WP2W18C05_02000	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2W18C05_02010	COG0583	DNA-binding transcription factor activity
WP2W18C05_02020	COG4221	oxidoreductase activity
WP2W18C05_02050	COG1770	oligopeptidase
WP2W18C05_02060	COG2358	TRAP transporter, solute receptor (TAXI family
WP2W18C05_02090	COG3714	YhhN family
WP2W18C05_02120	COG0583	DNA-binding transcription factor activity
WP2W18C05_02140	COG1301	dicarboxylic acid transport
WP2W18C05_02180	COG2095	MarC family integral membrane protein
WP2W18C05_02200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18C05_02220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2W18C05_02240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2W18C05_02290	COG3385	transposase activity
WP2W18C05_02300	COG0742	ribosomal rna small subunit methyltransferase
WP2W18C05_02310	COG0552	protein localization to endoplasmic reticulum
WP2W18C05_02320	COG2884	Cell division ATP-binding protein ftsE
WP2W18C05_02330	COG2177	Part of the ABC transporter FtsEX involved in
WP2W18C05_02350	COG0288	reversible hydration of carbon dioxide
WP2W18C05_02360	COG2188	Transcriptional regulator
WP2W18C05_02370	COG1228	amidohydrolase
WP2W18C05_02380	COG0010	Belongs to the arginase family
WP2W18C05_02390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP2W18C05_02400	COG2986	histidine ammonia-lyase
WP2W18C05_02410	COG0387	Pfam Sodium calcium exchanger
WP2W18C05_02420	COG2200	EAL domain
WP2W18C05_02550	COG1459	type II secretion system
WP2W18C05_02640	COG1077	Cell shape determining protein MreB Mrl
WP2W18C05_02650	COG1792	Involved in formation and maintenance of cell shape
WP2W18C05_02660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP2W18C05_02670	COG0424	maF-like protein
WP2W18C05_02680	COG1530	ribonuclease E activity
WP2W18C05_02690	COG3164	Protein of unknown function
WP2W18C05_02700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18C05_02710	COG0312	modulator of DNA gyrase
WP2W18C05_02740	COG0477	Major facilitator Superfamily
WP2W18C05_02760	COG2321	neutral zinc metallopeptidase
WP2W18C05_02830	COG0189	ligase activity
WP2W18C05_02840	COG0642	Histidine kinase
WP2W18C05_02850	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_02880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP2W18C05_02890	COG0352	thiamine-phosphate diphosphorylase activity
WP2W18C05_02890	COG0351	phosphomethylpyrimidine kinase
WP2W18C05_02910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2W18C05_02930	COG2022	thiamine diphosphate biosynthetic process
WP2W18C05_02940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2W18C05_02970	COG0110	maltose O-acetyltransferase activity
WP2W18C05_02990	COG2199	diguanylate cyclase activity
WP2W18C05_02990	COG2203	Gaf domain
WP2W18C05_03000	COG3932	Exopolysaccharide synthesis, ExoD
WP2W18C05_03030	COG1733	regulation of RNA biosynthetic process
WP2W18C05_03080	COG2226	methyltransferase
WP2W18C05_03100	COG1494	fructose-1,6-bisphosphatase
WP2W18C05_03120	COG3071	HemY protein
WP2W18C05_03130	COG2959	enzyme of heme biosynthesis
WP2W18C05_03150	COG0181	hydroxymethylbilane synthase activity
WP2W18C05_03160	COG3072	Adenylate cyclase
WP2W18C05_03170	COG0400	carboxylic ester hydrolase activity
WP2W18C05_03180	COG1965	Belongs to the frataxin family
WP2W18C05_03190	COG0019	diaminopimelate decarboxylase activity
WP2W18C05_03200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP2W18C05_03230	COG1011	Hydrolase
WP2W18C05_03250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP2W18C05_03260	COG0561	phosphatase activity
WP2W18C05_03280	COG1988	membrane-bound metal-dependent
WP2W18C05_03290	COG1058	Belongs to the CinA family
WP2W18C05_03290	COG1546	Belongs to the CinA family
WP2W18C05_03310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP2W18C05_03330	COG1522	sequence-specific DNA binding
WP2W18C05_03340	COG1368	sulfuric ester hydrolase activity
WP2W18C05_03370	COG1285	pathogenesis
WP2W18C05_03410	COG4221	oxidoreductase activity
WP2W18C05_03440	COG1979	alcohol dehydrogenase
WP2W18C05_03460	COG2873	o-acetylhomoserine
WP2W18C05_03520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP2W18C05_03540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP2W18C05_03550	COG2949	membrane
WP2W18C05_03560	COG3291	Pkd domain containing protein
WP2W18C05_03570	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18C05_03590	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP2W18C05_03600	COG0596	Alpha beta hydrolase
WP2W18C05_03610	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP2W18C05_03620	COG1169	isochorismate synthase
WP2W18C05_03630	COG1575	Belongs to the MenA family. Type 1 subfamily
WP2W18C05_03670	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_03680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18C05_03710	COG1671	Belongs to the UPF0178 family
WP2W18C05_03750	COG3263	regulation of cellular component size
WP2W18C05_03760	COG3722	fumarate hydratase activity
WP2W18C05_03770	COG0246	Mannitol dehydrogenase
WP2W18C05_03780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_03780	COG2213	PTS system mannitol-specific
WP2W18C05_03790	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP2W18C05_03810	COG3916	Acyl-homoserine-lactone synthase
WP2W18C05_03820	COG2771	luxR family
WP2W18C05_03850	COG1560	Kdo2-lipid A biosynthetic process
WP2W18C05_03860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP2W18C05_03860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP2W18C05_03870	COG1538	Outer membrane efflux protein
WP2W18C05_03880	COG0494	nUDIX hydrolase
WP2W18C05_03890	COG3151	Protein conserved in bacteria
WP2W18C05_03910	COG3150	esterase
WP2W18C05_03920	COG1051	belongs to the nudix hydrolase family
WP2W18C05_03950	COG1566	PFAM secretion protein HlyD family protein
WP2W18C05_03960	COG1289	transmembrane transporter activity
WP2W18C05_03990	COG3385	transposase activity
WP2W18C05_04010	COG3385	transposase activity
WP2W18C05_04120	COG0484	heat shock protein binding
WP2W18C05_04140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18C05_04180	COG0204	Acyl-transferase
WP2W18C05_04190	COG1842	Phage shock protein A
WP2W18C05_04220	COG2827	Endonuclease containing a URI domain
WP2W18C05_04230	COG2962	Rard protein
WP2W18C05_04240	COG1573	uracil-dna glycosylase
WP2W18C05_04260	COG0583	DNA-binding transcription factor activity
WP2W18C05_04270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP2W18C05_04280	COG1121	(ABC) transporter
WP2W18C05_04290	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP2W18C05_04340	COG0739	heme binding
WP2W18C05_04360	COG3068	Protein conserved in bacteria
WP2W18C05_04400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP2W18C05_04420	COG1546	Belongs to the CinA family
WP2W18C05_04430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP2W18C05_04440	COG2137	regulation of response to DNA damage stimulus
WP2W18C05_04450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP2W18C05_04460	COG0527	aspartate kinase activity
WP2W18C05_04470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP2W18C05_04480	COG1686	Belongs to the peptidase S11 family
WP2W18C05_04490	COG0586	Pfam SNARE associated Golgi protein
WP2W18C05_04500	COG1253	flavin adenine dinucleotide binding
WP2W18C05_04510	COG0525	valine-tRNA ligase activity
WP2W18C05_04520	COG2927	DNA polymerase III (CHI subunit)
WP2W18C05_04530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18C05_04540	COG0795	lipopolysaccharide-transporting ATPase activity
WP2W18C05_04550	COG0795	lipopolysaccharide-transporting ATPase activity
WP2W18C05_04580	COG0004	ammonium transporteR
WP2W18C05_04590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18C05_04620	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2W18C05_04630	COG0084	hydrolase, TatD family'
WP2W18C05_04640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18C05_04660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP2W18C05_04670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP2W18C05_04680	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP2W18C05_04700	COG4520	surface antigen
WP2W18C05_04710	COG3447	MASE1 domain protein
WP2W18C05_04710	COG5001	Diguanylate cyclase
WP2W18C05_04710	COG5002	protein histidine kinase activity
WP2W18C05_04730	COG0560	Phosphoserine phosphatase
WP2W18C05_04760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP2W18C05_04780	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP2W18C05_04790	COG0776	regulation of translation
WP2W18C05_04820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18C05_04830	COG0735	belongs to the Fur family
WP2W18C05_04870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP2W18C05_04880	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_04890	COG3022	response to hydroperoxide
WP2W18C05_04900	COG2805	Type II/IV secretion system protein
WP2W18C05_04920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP2W18C05_04930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP2W18C05_04940	COG0762	integral membrane protein
WP2W18C05_04950	COG1872	DUF167
WP2W18C05_04990	COG3112	Uncharacterised protein family (UPF0231)
WP2W18C05_05000	COG3835	regulator
WP2W18C05_05010	COG2610	gluconate transmembrane transporter activity
WP2W18C05_05020	COG1929	Belongs to the glycerate kinase type-1 family
WP2W18C05_05050	COG0583	DNA-binding transcription factor activity
WP2W18C05_05060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18C05_05090	COG0347	Belongs to the P(II) protein family
WP2W18C05_05120	COG3842	ATPase activity
WP2W18C05_05130	COG2837	iron assimilation
WP2W18C05_05140	COG1438	arginine binding
WP2W18C05_05150	COG1126	abc transporter atp-binding protein
WP2W18C05_05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_05170	COG4215	(ABC) transporter
WP2W18C05_05180	COG4160	amino acid transport
WP2W18C05_05190	COG0039	L-malate dehydrogenase activity
WP2W18C05_05200	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP2W18C05_05210	COG1017	nitric oxide dioxygenase activity
WP2W18C05_05210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18C05_05230	COG4536	flavin adenine dinucleotide binding
WP2W18C05_05240	COG4137	Cytochrome C assembly protein
WP2W18C05_05250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP2W18C05_05260	COG0228	four-way junction DNA binding
WP2W18C05_05270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP2W18C05_05280	COG0336	Belongs to the RNA methyltransferase TrmD family
WP2W18C05_05290	COG0335	large ribosomal subunit rRNA binding
WP2W18C05_05310	COG3066	DNA modification
WP2W18C05_05320	COG1051	belongs to the nudix hydrolase family
WP2W18C05_05340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP2W18C05_05350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP2W18C05_05360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2W18C05_05380	COG0583	DNA-binding transcription factor activity
WP2W18C05_05390	COG0640	Transcriptional regulator
WP2W18C05_05400	COG0268	Binds directly to 16S ribosomal RNA
WP2W18C05_05410	COG0728	peptidoglycan biosynthetic process
WP2W18C05_05420	COG0196	riboflavin kinase activity
WP2W18C05_05430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP2W18C05_05440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP2W18C05_05450	COG1047	Peptidyl-prolyl cis-trans
WP2W18C05_05460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP2W18C05_05470	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2W18C05_05540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18C05_05540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP2W18C05_05570	COG1854	S-ribosylhomocysteine lyase activity
WP2W18C05_05580	COG3706	GGDEF domain
WP2W18C05_05590	COG0557	exoribonuclease II activity
WP2W18C05_05600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2W18C05_05620	COG2153	protein acetylation
WP2W18C05_05640	COG1914	H( )-stimulated, divalent metal cation uptake system
WP2W18C05_05660	COG0360	Binds together with S18 to 16S ribosomal RNA
WP2W18C05_05670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP2W18C05_05680	COG0359	binds to the 23S rRNA
WP2W18C05_05760	COG1238	metal cluster binding
WP2W18C05_05770	COG0612	Peptidase, M16
WP2W18C05_05780	COG2918	glutathione biosynthetic process
WP2W18C05_05790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2W18C05_05800	COG1027	Aspartate ammonia-lyase
WP2W18C05_05810	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP2W18C05_05820	COG0534	Mate efflux family protein
WP2W18C05_05830	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP2W18C05_05840	COG0459	protein refolding
WP2W18C05_05880	COG0564	pseudouridine synthase activity
WP2W18C05_05890	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP2W18C05_05900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP2W18C05_05920	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP2W18C05_05930	COG4208	sulfate ABC transporter
WP2W18C05_05940	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP2W18C05_05950	COG0583	DNA-binding transcription factor activity
WP2W18C05_05960	COG3397	chitin binding
WP2W18C05_05970	COG0840	transmembrane signaling receptor activity
WP2W18C05_06020	COG1328	CTP reductase activity
WP2W18C05_06030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2W18C05_06060	COG1448	Aminotransferase
WP2W18C05_06070	COG2194	sulfuric ester hydrolase activity
WP2W18C05_06110	COG1215	transferase activity, transferring glycosyl groups
WP2W18C05_06130	COG0457	Tetratricopeptide repeat
WP2W18C05_06130	COG3118	belongs to the thioredoxin family
WP2W18C05_06200	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_06210	COG0840	transmembrane signaling receptor activity
WP2W18C05_06230	COG4166	transmembrane transport
WP2W18C05_06260	COG1024	Enoyl-CoA hydratase
WP2W18C05_06290	COG4221	oxidoreductase activity
WP2W18C05_06300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18C05_06310	COG0442	prolyl-tRNA aminoacylation
WP2W18C05_06320	COG0840	transmembrane signaling receptor activity
WP2W18C05_06330	COG0632	four-way junction helicase activity
WP2W18C05_06340	COG2255	four-way junction helicase activity
WP2W18C05_06350	COG1271	oxidase subunit
WP2W18C05_06360	COG1294	oxidase, subunit
WP2W18C05_06370	COG4890	Cyd operon protein YbgT
WP2W18C05_06380	COG3790	cyd operon protein YbgE
WP2W18C05_06390	COG0824	Thioesterase
WP2W18C05_06400	COG0811	peptide transport
WP2W18C05_06430	COG0823	Involved in the tonB-independent uptake of proteins
WP2W18C05_06440	COG2885	chlorophyll binding
WP2W18C05_06450	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP2W18C05_06460	COG0840	transmembrane signaling receptor activity
WP2W18C05_06470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP2W18C05_06490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2W18C05_06500	COG1640	4-alpha-glucanotransferase
WP2W18C05_06510	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP2W18C05_06560	COG1051	belongs to the nudix hydrolase family
WP2W18C05_06570	COG2130	NADP-dependent
WP2W18C05_06580	COG1846	Transcriptional regulator
WP2W18C05_06640	COG0561	phosphatase activity
WP2W18C05_06670	COG0733	neurotransmitter:sodium symporter activity
WP2W18C05_06680	COG0733	neurotransmitter:sodium symporter activity
WP2W18C05_06710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18C05_06740	COG1794	racemase activity, acting on amino acids and derivatives
WP2W18C05_06760	COG1022	Amp-dependent synthetase and ligase
WP2W18C05_06780	COG0456	acetyltransferase
WP2W18C05_06810	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP2W18C05_06820	COG5001	Diguanylate cyclase
WP2W18C05_06820	COG5002	protein histidine kinase activity
WP2W18C05_06860	COG0456	acetyltransferase
WP2W18C05_06880	COG0456	acetyltransferase
WP2W18C05_06890	COG1902	pentaerythritol trinitrate reductase activity
WP2W18C05_06920	COG2957	Belongs to the agmatine deiminase family
WP2W18C05_06930	COG0154	amidase activity
WP2W18C05_06940	COG2801	Transposase and inactivated derivatives
WP2W18C05_07020	COG2207	Transcriptional regulator
WP2W18C05_07020	COG1917	Cupin 2, conserved barrel domain protein
WP2W18C05_07040	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_07060	COG2199	diguanylate cyclase activity
WP2W18C05_07060	COG2203	Gaf domain
WP2W18C05_07130	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP2W18C05_07150	COG1136	(ABC) transporter
WP2W18C05_07150	COG0577	efflux transmembrane transporter activity
WP2W18C05_07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_07170	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_07180	COG2205	protein histidine kinase activity
WP2W18C05_07250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18C05_07270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP2W18C05_07290	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP2W18C05_07300	COG1178	ABC-type Fe3 transport system permease component
WP2W18C05_07310	COG4143	(ABC) transporter
WP2W18C05_07340	COG0066	3-isopropylmalate dehydratase activity
WP2W18C05_07350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP2W18C05_07360	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18C05_07370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2W18C05_07390	COG0671	phosphoesterase, PA-phosphatase related
WP2W18C05_07420	COG0028	Belongs to the TPP enzyme family
WP2W18C05_07430	COG0440	acetolactate synthase activity
WP2W18C05_07440	COG0857	belongs to the CobB CobQ family
WP2W18C05_07440	COG0280	phosphate acetyltransferase
WP2W18C05_07450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP2W18C05_07470	COG3013	Belongs to the UPF0304 family
WP2W18C05_07480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP2W18C05_07490	COG2716	regulation of RNA biosynthetic process
WP2W18C05_07500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18C05_07510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP2W18C05_07520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP2W18C05_07550	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP2W18C05_07590	COG0784	Response regulator, receiver
WP2W18C05_07590	COG2198	Histidine kinase
WP2W18C05_07590	COG5002	protein histidine kinase activity
WP2W18C05_07600	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WP2W18C05_07620	COG2205	protein histidine kinase activity
WP2W18C05_07620	COG0784	Response regulator, receiver
WP2W18C05_07660	COG1464	Belongs to the NlpA lipoprotein family
WP2W18C05_07670	COG2011	ABC-type metal ion transport system permease component
WP2W18C05_07680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18C05_07720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP2W18C05_07720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP2W18C05_07730	COG0802	atpase or kinase
WP2W18C05_07750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP2W18C05_07760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP2W18C05_07770	COG1923	regulation of RNA biosynthetic process
WP2W18C05_07780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP2W18C05_07790	COG0330	HflC and HflK could
WP2W18C05_07800	COG0330	HflC and HflK could
WP2W18C05_07810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP2W18C05_07820	COG0142	geranyltranstransferase activity
WP2W18C05_07830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP2W18C05_07840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP2W18C05_07850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP2W18C05_07870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18C05_07880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2W18C05_07900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2W18C05_07910	COG2967	ApaG domain
WP2W18C05_07920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP2W18C05_07930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP2W18C05_07950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP2W18C05_07960	COG3178	'Phosphotransferase
WP2W18C05_07970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP2W18C05_07980	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2W18C05_07990	COG2252	PERMEase
WP2W18C05_08010	COG0488	(ABC) transporter
WP2W18C05_08020	COG0582	viral genome integration into host DNA
WP2W18C05_08040	COG3385	transposase activity
WP2W18C05_08060	COG0629	single-stranded DNA binding
WP2W18C05_08390	COG1802	Transcriptional regulator
WP2W18C05_08390	COG4626	Terminase
WP2W18C05_08420	COG0616	signal peptide processing
WP2W18C05_08500	COG4386	tail sheath protein
WP2W18C05_08540	COG2314	TM2 domain
WP2W18C05_08590	COG3299	homolog of phage Mu protein gp47
WP2W18C05_08600	COG3778	Protein conserved in bacteria
WP2W18C05_08670	COG0741	lytic transglycosylase activity
WP2W18C05_08680	COG0463	Glycosyl transferase, family 2
WP2W18C05_08700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WP2W18C05_08750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18C05_08770	COG3721	Heme iron utilization protein
WP2W18C05_08780	COG0748	coenzyme F420 binding
WP2W18C05_08830	COG2814	Major facilitator Superfamily
WP2W18C05_08840	COG2205	protein histidine kinase activity
WP2W18C05_08840	COG2202	Pas domain
WP2W18C05_08860	COG2226	methyltransferase
WP2W18C05_08880	COG1765	OsmC-like protein
WP2W18C05_08910	COG3954	Phosphoribulokinase
WP2W18C05_08920	COG3089	Belongs to the UPF0270 family
WP2W18C05_08930	COG4251	negative regulation of phosphorylation
WP2W18C05_08930	COG5001	Diguanylate cyclase
WP2W18C05_08930	COG2203	Gaf domain
WP2W18C05_08930	COG3706	GGDEF domain
WP2W18C05_08940	COG0429	hydrolase of the alpha beta-hydrolase fold
WP2W18C05_08950	COG0835	chemotaxis
WP2W18C05_08950	COG0784	Response regulator, receiver
WP2W18C05_08970	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP2W18C05_08980	COG1047	Peptidyl-prolyl cis-trans
WP2W18C05_08990	COG2900	Belongs to the SlyX family
WP2W18C05_09010	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2W18C05_09020	COG2204	response regulator
WP2W18C05_09060	COG0737	Belongs to the 5'-nucleotidase family
WP2W18C05_09080	COG0737	Belongs to the 5'-nucleotidase family
WP2W18C05_09130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18C05_09140	COG0506	proline dehydrogenase activity
WP2W18C05_09140	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18C05_09140	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WP2W18C05_09160	COG0114	fumarate hydratase activity
WP2W18C05_09180	COG1566	PFAM secretion protein HlyD family protein
WP2W18C05_09310	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_09320	COG0826	peptidase U32
WP2W18C05_09340	COG3813	Protein conserved in bacteria
WP2W18C05_09380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP2W18C05_09460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP2W18C05_09510	COG0300	oxidoreductase activity
WP2W18C05_09530	COG0840	transmembrane signaling receptor activity
WP2W18C05_09560	COG2610	gluconate transmembrane transporter activity
WP2W18C05_09570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2W18C05_09580	COG3622	Belongs to the hyi family
WP2W18C05_09590	COG0235	Class ii aldolase
WP2W18C05_09600	COG3395	kinase activity
WP2W18C05_09610	COG2084	Dehydrogenase
WP2W18C05_09620	COG1349	DNA-binding transcription factor activity
WP2W18C05_09640	COG2133	pyrroloquinoline quinone binding
WP2W18C05_09690	COG3385	transposase activity
WP2W18C05_09730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2W18C05_09740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18C05_09800	COG3039	Transposase
WP2W18C05_09820	COG3385	transposase activity
WP2W18C05_09840	COG3385	transposase activity
WP2W18C05_09880	COG2003	Belongs to the UPF0758 family
WP2W18C05_09960	COG5377	YqaJ viral recombinase family
WP2W18C05_10010	COG1605	Chorismate mutase
WP2W18C05_10010	COG0077	Prephenate dehydratase
WP2W18C05_10060	COG3272	Protein of unknown function (DUF1722)
WP2W18C05_10070	COG0789	Transcriptional regulator
WP2W18C05_10080	COG0415	Belongs to the DNA photolyase family
WP2W18C05_10100	COG4221	oxidoreductase activity
WP2W18C05_10130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2W18C05_10180	COG0783	Belongs to the Dps family
WP2W18C05_10190	COG1151	hydroxylamine reductase activity
WP2W18C05_10210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18C05_10240	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP2W18C05_10250	COG2723	6-phospho-beta-galactosidase activity
WP2W18C05_10260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2W18C05_10260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2W18C05_10270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2W18C05_10280	COG2273	Hydrolase Family 16
WP2W18C05_10280	COG5297	Belongs to the glycosyl hydrolase family 6
WP2W18C05_10290	COG1472	Belongs to the glycosyl hydrolase 3 family
WP2W18C05_10300	COG0840	transmembrane signaling receptor activity
WP2W18C05_10310	COG2182	Extracellular solute-binding protein
WP2W18C05_10320	COG1609	Transcriptional regulator
WP2W18C05_10360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_10380	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_10390	COG5002	protein histidine kinase activity
WP2W18C05_10390	COG5000	phosphorelay sensor kinase activity
WP2W18C05_10400	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18C05_10410	COG2771	luxR family
WP2W18C05_10430	COG3501	Rhs element vgr protein
WP2W18C05_10460	COG3385	transposase activity
WP2W18C05_10580	COG3385	transposase activity
WP2W18C05_10600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP2W18C05_10610	COG1666	GTP binding
WP2W18C05_10630	COG2211	Major facilitator Superfamily
WP2W18C05_10650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2W18C05_10670	COG2813	Specifically methylates the guanine in position
WP2W18C05_10680	COG0271	Belongs to the BolA IbaG family
WP2W18C05_10690	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18C05_10700	COG1805	sodium ion transport
WP2W18C05_10710	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18C05_10720	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18C05_10730	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18C05_10740	COG2871	sodium ion transport
WP2W18C05_10750	COG1477	protein flavinylation
WP2W18C05_10780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18C05_10790	COG0840	transmembrane signaling receptor activity
WP2W18C05_10800	COG0583	DNA-binding transcription factor activity
WP2W18C05_10830	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP2W18C05_10850	COG0473	3-isopropylmalate dehydrogenase activity
WP2W18C05_10860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18C05_10870	COG1611	Belongs to the LOG family
WP2W18C05_10880	COG3706	GGDEF domain
WP2W18C05_10900	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2W18C05_10900	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2W18C05_10920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP2W18C05_10970	COG3098	single-species biofilm formation
WP2W18C05_10980	COG0564	pseudouridine synthase activity
WP2W18C05_11000	COG4580	involved in the transport of maltose and maltodextrins
WP2W18C05_11030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18C05_11030	COG1263	PTS System
WP2W18C05_11050	COG2171	N-acyltransferase activity
WP2W18C05_11060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP2W18C05_11070	COG0024	Methionine aminopeptidase
WP2W18C05_11080	COG0052	Belongs to the universal ribosomal protein uS2 family
WP2W18C05_11090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP2W18C05_11100	COG0528	UMP kinase activity
WP2W18C05_11110	COG0233	cytoplasmic translational termination
WP2W18C05_11120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP2W18C05_11130	COG0575	Belongs to the CDS family
WP2W18C05_11140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP2W18C05_11150	COG0750	zinc metalloprotease
WP2W18C05_11180	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18C05_11190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2W18C05_11200	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18C05_11210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18C05_11220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP2W18C05_11240	COG0825	malonyl-CoA metabolic process
WP2W18C05_11270	COG0814	amino acid
WP2W18C05_11280	COG0531	amino acid
WP2W18C05_11320	COG3590	peptidase
WP2W18C05_11330	COG0037	tRNA processing
WP2W18C05_11340	COG3706	GGDEF domain
WP2W18C05_11410	COG0366	Alpha amylase catalytic
WP2W18C05_11440	COG0463	Glycosyl transferase, family 2
WP2W18C05_11470	COG3385	transposase activity
WP2W18C05_11490	COG2989	Protein conserved in bacteria
WP2W18C05_11500	COG3108	Peptidase M15
WP2W18C05_11520	COG2860	membrane
WP2W18C05_11540	COG1196	nuclear chromosome segregation
WP2W18C05_11550	COG3115	cell septum assembly
WP2W18C05_11560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP2W18C05_11580	COG1328	CTP reductase activity
WP2W18C05_11590	COG0602	queuosine metabolic process
WP2W18C05_11640	COG1566	PFAM secretion protein HlyD family protein
WP2W18C05_11660	COG3290	protein histidine kinase activity
WP2W18C05_11690	COG0667	Aldo Keto reductase
WP2W18C05_11700	COG0697	spore germination
WP2W18C05_11720	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_11730	COG3284	Transcriptional regulator
WP2W18C05_11740	COG3706	GGDEF domain
WP2W18C05_11750	COG0346	lactoylglutathione lyase activity
WP2W18C05_11760	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_11770	COG5002	protein histidine kinase activity
WP2W18C05_11790	COG4783	chaperone-mediated protein folding
WP2W18C05_11810	COG1940	carbohydrate kinase activity
WP2W18C05_11820	COG3142	Participates in the control of copper homeostasis
WP2W18C05_11830	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2W18C05_11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_11880	COG4597	amino acid ABC transporter
WP2W18C05_11890	COG0765	amino acid transport
WP2W18C05_11900	COG1126	abc transporter atp-binding protein
WP2W18C05_11920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP2W18C05_11930	COG0678	peroxiredoxin activity
WP2W18C05_11950	COG0019	diaminopimelate decarboxylase activity
WP2W18C05_11960	COG1115	amino acid carrier protein
WP2W18C05_11970	COG0095	Lipoate-protein ligase
WP2W18C05_11980	COG2233	PERMEase
WP2W18C05_12010	COG0534	Mate efflux family protein
WP2W18C05_12020	COG2207	Transcriptional regulator
WP2W18C05_12030	COG0281	malic enzyme
WP2W18C05_12060	COG3385	transposase activity
WP2W18C05_12110	COG0733	neurotransmitter:sodium symporter activity
WP2W18C05_12120	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18C05_12130	COG3706	GGDEF domain
WP2W18C05_12150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_12160	COG1032	radical SAM domain protein
WP2W18C05_12180	COG1032	radical SAM domain protein
WP2W18C05_12270	COG0673	inositol 2-dehydrogenase activity
WP2W18C05_12280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP2W18C05_12290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2W18C05_12300	COG1196	nuclear chromosome segregation
WP2W18C05_12300	COG0741	lytic transglycosylase activity
WP2W18C05_12300	COG0739	heme binding
WP2W18C05_12350	COG0788	formyltetrahydrofolate deformylase activity
WP2W18C05_12360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2W18C05_12380	COG3118	belongs to the thioredoxin family
WP2W18C05_12400	COG0791	NLP P60 protein
WP2W18C05_12410	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP2W18C05_12440	COG1376	ErfK ybiS ycfS ynhG family protein
WP2W18C05_12440	COG1388	LysM domain
WP2W18C05_12450	COG0784	Response regulator, receiver
WP2W18C05_12450	COG2205	protein histidine kinase activity
WP2W18C05_12480	COG2205	protein histidine kinase activity
WP2W18C05_12480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_12490	COG3384	dioxygenase
WP2W18C05_12510	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP2W18C05_12530	COG0531	amino acid
WP2W18C05_12550	COG0531	amino acid
WP2W18C05_12580	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_12590	COG1396	sequence-specific DNA binding
WP2W18C05_12590	COG1917	Cupin 2, conserved barrel domain protein
WP2W18C05_12600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18C05_12670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP2W18C05_12670	COG4651	solute:proton antiporter activity
WP2W18C05_12680	COG0405	Gamma-glutamyltransferase
WP2W18C05_12700	COG2974	May be involved in recombination
WP2W18C05_12710	COG1247	-acetyltransferase
WP2W18C05_12720	COG0420	3'-5' exonuclease activity
WP2W18C05_12740	COG3038	cytochrome b561
WP2W18C05_12750	COG2190	(PTS) system
WP2W18C05_12770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_12780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP2W18C05_12790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18C05_12820	COG1720	tRNA m6t6A37 methyltransferase activity
WP2W18C05_12870	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP2W18C05_12880	COG4988	ABC transporter
WP2W18C05_12890	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_12920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18C05_12950	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP2W18C05_12960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP2W18C05_12980	COG0083	homoserine kinase activity
WP2W18C05_12990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2W18C05_13020	COG2801	Transposase and inactivated derivatives
WP2W18C05_13050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WP2W18C05_13090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
WP2W18C05_13110	COG3220	belongs to the UPF0276 family
WP2W18C05_13170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18C05_13180	COG1289	transmembrane transporter activity
WP2W18C05_13190	COG1763	Mo-molybdopterin cofactor biosynthetic process
WP2W18C05_13200	COG0746	molybdenum cofactor guanylyltransferase activity
WP2W18C05_13210	COG0281	malic enzyme
WP2W18C05_13230	COG3385	transposase activity
WP2W18C05_13240	COG4584	PFAM Integrase catalytic
WP2W18C05_13250	COG1484	DNA-dependent DNA replication
WP2W18C05_13260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2W18C05_13290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP2W18C05_13440	COG3385	transposase activity
WP2W18C05_13470	COG2003	Belongs to the UPF0758 family
WP2W18C05_13560	COG5377	YqaJ viral recombinase family
WP2W18C05_13600	COG5433	transposase activity
WP2W18C05_13630	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP2W18C05_13700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WP2W18C05_13740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP2W18C05_13900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2W18C05_13920	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP2W18C05_13940	COG0443	Heat shock 70 kDa protein
WP2W18C05_13950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18C05_14010	COG2801	Transposase and inactivated derivatives
WP2W18C05_14030	COG0582	viral genome integration into host DNA
WP2W18C05_14040	COG0012	GTP binding
WP2W18C05_14050	COG0193	aminoacyl-tRNA hydrolase activity
WP2W18C05_14060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP2W18C05_14070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP2W18C05_14080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP2W18C05_14090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP2W18C05_14100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP2W18C05_14110	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2W18C05_14130	COG2912	Transglutaminase-like superfamily
WP2W18C05_14140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP2W18C05_14150	COG3385	transposase activity
WP2W18C05_14200	COG3264	Mechanosensitive ion channel
WP2W18C05_14200	COG1196	nuclear chromosome segregation
WP2W18C05_14220	COG2850	peptidyl-arginine hydroxylation
WP2W18C05_14230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP2W18C05_14240	COG2915	High frequency lysogenization protein hflD homolog
WP2W18C05_14250	COG0482	sulfurtransferase activity
WP2W18C05_14270	COG1187	pseudouridine synthase activity
WP2W18C05_14280	COG0456	acetyltransferase
WP2W18C05_14350	COG0538	isocitrate dehydrogenase activity
WP2W18C05_14370	COG3048	D-serine ammonia-lyase activity
WP2W18C05_14380	COG0583	DNA-binding transcription factor activity
WP2W18C05_14390	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18C05_14400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18C05_14410	COG2375	cellular response to nickel ion
WP2W18C05_14430	COG1136	(ABC) transporter
WP2W18C05_14430	COG0577	efflux transmembrane transporter activity
WP2W18C05_14440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_14460	COG0497	DNA recombination
WP2W18C05_14470	COG3706	GGDEF domain
WP2W18C05_14480	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP2W18C05_14490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP2W18C05_14500	COG0443	Heat shock 70 kDa protein
WP2W18C05_14510	COG0484	heat shock protein binding
WP2W18C05_14570	COG1285	pathogenesis
WP2W18C05_14590	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18C05_14630	COG2391	methyltransferase activity
WP2W18C05_14680	COG0095	Lipoate-protein ligase
WP2W18C05_14710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_14740	COG0708	Exodeoxyribonuclease III
WP2W18C05_14760	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_14790	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
WP2W18C05_14820	COG1846	Transcriptional regulator
WP2W18C05_14860	COG0583	DNA-binding transcription factor activity
WP2W18C05_14870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2W18C05_14880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP2W18C05_14890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP2W18C05_14900	COG1845	cytochrome c oxidase, subunit III
WP2W18C05_14910	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP2W18C05_14920	COG0109	protoheme IX farnesyltransferase activity
WP2W18C05_14930	COG0109	protoheme IX farnesyltransferase activity
WP2W18C05_14940	COG2814	Major facilitator Superfamily
WP2W18C05_14950	COG5507	3-demethylubiquinone-9 3-methyltransferase
WP2W18C05_14960	COG2175	clavaminate synthase activity
WP2W18C05_14970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18C05_14980	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
WP2W18C05_14990	COG4521	taurine ABC transporter
WP2W18C05_15130	COG3385	transposase activity
WP2W18C05_15150	COG0159	tryptophan synthase activity
WP2W18C05_15160	COG0133	tryptophan synthase activity
WP2W18C05_15170	COG0135	phosphoribosylanthranilate isomerase activity
WP2W18C05_15170	COG0134	indole-3-glycerol-phosphate synthase activity
WP2W18C05_15180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2W18C05_15190	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2W18C05_15190	COG0512	Glutamine amidotransferase of anthranilate synthase
WP2W18C05_15200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP2W18C05_15210	COG0613	PHP domain protein
WP2W18C05_15220	COG0009	L-threonylcarbamoyladenylate synthase
WP2W18C05_15240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP2W18C05_15270	COG1946	Acyl-CoA thioesterase
WP2W18C05_15300	COG1309	transcriptional regulator
WP2W18C05_15310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_15320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_15380	COG3385	transposase activity
WP2W18C05_15460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP2W18C05_15470	COG3385	transposase activity
WP2W18C05_15490	COG1960	acyl-CoA dehydrogenase activity
WP2W18C05_15500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2W18C05_15520	COG0469	pyruvate kinase activity
WP2W18C05_15530	COG1737	Transcriptional regulator
WP2W18C05_15540	COG0837	glucose binding
WP2W18C05_15560	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_15580	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP2W18C05_15600	COG3385	transposase activity
WP2W18C05_15650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
WP2W18C05_15700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP2W18C05_15740	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WP2W18C05_15760	COG3132	Protein of unknown function, DUF480
WP2W18C05_15810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WP2W18C05_15840	COG1278	Cold shock
WP2W18C05_15890	COG4166	transmembrane transport
WP2W18C05_15900	COG0697	spore germination
WP2W18C05_15920	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2W18C05_15950	COG4166	transmembrane transport
WP2W18C05_15960	COG0622	Phosphoesterase
WP2W18C05_15990	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP2W18C05_16010	COG0835	chemotaxis
WP2W18C05_16010	COG0784	Response regulator, receiver
WP2W18C05_16020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP2W18C05_16030	COG1815	bacterial-type flagellum-dependent cell motility
WP2W18C05_16060	COG1749	Flagellar hook protein flgE
WP2W18C05_16090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP2W18C05_16100	COG1706	bacterial-type flagellum-dependent cell motility
WP2W18C05_16110	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP2W18C05_16110	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP2W18C05_16140	COG2239	Acts as a magnesium transporter
WP2W18C05_16160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP2W18C05_16170	COG2716	regulation of RNA biosynthetic process
WP2W18C05_16200	COG3852	Histidine kinase
WP2W18C05_16220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP2W18C05_16230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP2W18C05_16240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP2W18C05_16250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP2W18C05_16300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP2W18C05_16320	COG0590	tRNA wobble adenosine to inosine editing
WP2W18C05_16330	COG0573	inorganic phosphate transmembrane transporter activity
WP2W18C05_16340	COG0581	inorganic phosphate transmembrane transporter activity
WP2W18C05_16360	COG0704	Plays a role in the regulation of phosphate uptake
WP2W18C05_16370	COG1253	flavin adenine dinucleotide binding
WP2W18C05_16400	COG0531	amino acid
WP2W18C05_16430	COG1126	abc transporter atp-binding protein
WP2W18C05_16440	COG0765	amino acid transport
WP2W18C05_16450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_16460	COG3706	GGDEF domain
WP2W18C05_16470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2W18C05_16510	COG3385	transposase activity
WP2W18C05_16530	COG1785	Belongs to the alkaline phosphatase family
WP2W18C05_16540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP2W18C05_16560	COG0477	Major facilitator Superfamily
WP2W18C05_16570	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP2W18C05_16590	COG1199	ATP-dependent helicase activity
WP2W18C05_16650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP2W18C05_16680	COG1448	Aminotransferase
WP2W18C05_16690	COG0433	COG0433 Predicted ATPase
WP2W18C05_16720	COG2333	competence protein COMEC
WP2W18C05_16720	COG0658	competence protein
WP2W18C05_16730	COG1132	(ABC) transporter
WP2W18C05_16740	COG1663	tetraacyldisaccharide 4'-kinase activity
WP2W18C05_16750	COG2835	tetraacyldisaccharide 4'-kinase activity
WP2W18C05_16760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP2W18C05_16770	COG2197	response regulator
WP2W18C05_16780	COG0322	excinuclease ABC activity
WP2W18C05_16900	COG0582	viral genome integration into host DNA
WP2W18C05_16920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WP2W18C05_16930	COG1061	Type III restriction enzyme res subunit
WP2W18C05_16940	COG1002	Type II restriction enzyme, methylase subunits
WP2W18C05_16970	COG3385	transposase activity
WP2W18C05_16990	COG0604	alcohol dehydrogenase
WP2W18C05_17000	COG1309	transcriptional regulator
WP2W18C05_17010	COG2261	transglycosylase associated protein
WP2W18C05_17020	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2W18C05_17040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2W18C05_17060	COG2801	Transposase and inactivated derivatives
WP2W18C05_17130	COG3385	transposase activity
WP2W18C05_17140	COG0840	transmembrane signaling receptor activity
WP2W18C05_17190	COG0741	lytic transglycosylase activity
WP2W18C05_17230	COG4962	Type ii secretion system protein e
WP2W18C05_17260	COG3451	type IV secretory pathway VirB4
WP2W18C05_17290	COG3846	protein secretion by the type IV secretion system
WP2W18C05_17320	COG2948	multi-organism process
WP2W18C05_17330	COG0583	DNA-binding transcription factor activity
WP2W18C05_17340	COG1846	Transcriptional regulator
WP2W18C05_17400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_17450	COG0583	DNA-binding transcription factor activity
WP2W18C05_17470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18C05_17480	COG0625	glutathione transferase activity
WP2W18C05_17560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2W18C05_17630	COG3385	transposase activity
WP2W18C05_17660	COG2199	diguanylate cyclase activity
WP2W18C05_17660	COG2203	Gaf domain
WP2W18C05_17730	COG2119	membrane
WP2W18C05_17740	COG0023	Translation Initiation Factor
WP2W18C05_17760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP2W18C05_17810	COG4139	cobalamin transport
WP2W18C05_17820	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP2W18C05_17830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18C05_17840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP2W18C05_17850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18C05_17860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP2W18C05_17870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP2W18C05_17890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP2W18C05_17900	COG0505	Belongs to the CarA family
WP2W18C05_17910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP2W18C05_17920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2W18C05_17930	COG3706	GGDEF domain
WP2W18C05_17990	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_18010	COG4104	PAAR repeat-containing protein
WP2W18C05_18050	COG0493	'glutamate synthase
WP2W18C05_18060	COG0070	glutamate synthase
WP2W18C05_18060	COG0069	glutamate synthase activity
WP2W18C05_18060	COG0067	glutamate synthase
WP2W18C05_18070	COG1242	4 iron, 4 sulfur cluster binding
WP2W18C05_18160	COG1113	amino acid transport
WP2W18C05_18180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP2W18C05_18190	COG0574	Belongs to the PEP-utilizing enzyme family
WP2W18C05_18190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP2W18C05_18210	COG2199	diguanylate cyclase activity
WP2W18C05_18210	COG2203	Gaf domain
WP2W18C05_18220	COG1119	ATPase activity
WP2W18C05_18260	COG1464	Belongs to the NlpA lipoprotein family
WP2W18C05_18280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2W18C05_18290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2W18C05_18310	COG0101	tRNA pseudouridine synthase activity
WP2W18C05_18320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP2W18C05_18330	COG0285	dihydrofolate synthase activity
WP2W18C05_18340	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP2W18C05_18350	COG2920	part of a sulfur-relay system
WP2W18C05_18360	COG1289	transmembrane transporter activity
WP2W18C05_18370	COG0670	Belongs to the BI1 family
WP2W18C05_18450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP2W18C05_18470	COG2175	clavaminate synthase activity
WP2W18C05_18480	COG3246	L-lysine catabolic process to acetate
WP2W18C05_18490	COG2814	Major facilitator Superfamily
WP2W18C05_18510	COG2855	membrane
WP2W18C05_18610	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18C05_18630	COG5001	Diguanylate cyclase
WP2W18C05_18640	COG0564	pseudouridine synthase activity
WP2W18C05_18670	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP2W18C05_18690	COG0625	glutathione transferase activity
WP2W18C05_18720	COG0367	asparagine synthase
WP2W18C05_18740	COG0647	UMP catabolic process
WP2W18C05_18750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2W18C05_18770	COG1902	pentaerythritol trinitrate reductase activity
WP2W18C05_18780	COG1253	flavin adenine dinucleotide binding
WP2W18C05_18800	COG0277	FAD linked oxidase domain protein
WP2W18C05_18800	COG0247	lactate metabolic process
WP2W18C05_18820	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18C05_18850	COG5001	Diguanylate cyclase
WP2W18C05_18860	COG0583	DNA-binding transcription factor activity
WP2W18C05_18870	COG2814	Major facilitator Superfamily
WP2W18C05_18880	COG2056	Na+-H+ antiporter family
WP2W18C05_18890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18C05_18920	COG0483	inositol monophosphate 1-phosphatase activity
WP2W18C05_18940	COG0625	glutathione transferase activity
WP2W18C05_18950	COG0625	glutathione transferase activity
WP2W18C05_18970	COG0601	transmembrane transport
WP2W18C05_18980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18C05_19000	COG2814	Major facilitator Superfamily
WP2W18C05_19030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18C05_19040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18C05_19050	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP2W18C05_19060	COG0509	glycine decarboxylation via glycine cleavage system
WP2W18C05_19070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2W18C05_19070	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2W18C05_19140	COG3634	alkyl hydroperoxide reductase activity
WP2W18C05_19150	COG0450	alkyl hydroperoxide reductase
WP2W18C05_19160	COG0517	IMP dehydrogenase activity
WP2W18C05_19170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP2W18C05_19180	COG0343	queuine tRNA-ribosyltransferase activity
WP2W18C05_19190	COG1862	Preprotein translocase
WP2W18C05_19200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18C05_19210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18C05_19220	COG2897	thiosulfate sulfurtransferase activity
WP2W18C05_19240	COG0826	peptidase U32
WP2W18C05_19250	COG0826	peptidase U32
WP2W18C05_19260	COG3154	lipid carrier protein
WP2W18C05_19290	COG1104	cysteine desulfurase activity
WP2W18C05_19300	COG0822	iron-sulfur transferase activity
WP2W18C05_19320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2W18C05_19330	COG0443	Heat shock 70 kDa protein
WP2W18C05_19340	COG0633	Ferredoxin
WP2W18C05_19360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18C05_19370	COG0105	UTP biosynthetic process
WP2W18C05_19380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP2W18C05_19400	COG1426	Protein conserved in bacteria
WP2W18C05_19410	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WP2W18C05_19420	COG0124	histidyl-tRNA synthetase
WP2W18C05_19430	COG2976	Protein conserved in bacteria
WP2W18C05_19440	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18C05_19450	COG1160	GTP binding
WP2W18C05_19460	COG1645	bacterial-type flagellum-dependent swarming motility
WP2W18C05_19480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2W18C05_19490	COG0047	phosphoribosylformylglycinamidine synthase activity
WP2W18C05_19490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP2W18C05_19500	COG1007	ATP synthesis coupled electron transport
WP2W18C05_19510	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18C05_19530	COG0713	ATP synthesis coupled electron transport
WP2W18C05_19540	COG0839	Belongs to the complex I subunit 6 family
WP2W18C05_19550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18C05_19560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP2W18C05_19570	COG1034	ATP synthesis coupled electron transport
WP2W18C05_19600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18C05_19600	COG0649	NAD binding
WP2W18C05_19610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18C05_19620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2W18C05_19630	COG1360	Flagellar Motor Protein
WP2W18C05_19640	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18C05_19660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP2W18C05_19700	COG0724	RNA recognition motif
WP2W18C05_19710	COG4989	oxidoreductase activity
WP2W18C05_19760	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_19770	COG0583	DNA-binding transcription factor activity
WP2W18C05_19790	COG5001	Diguanylate cyclase
WP2W18C05_19790	COG3300	MHYT domain
WP2W18C05_19800	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP2W18C05_19830	COG3385	transposase activity
WP2W18C05_19880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2W18C05_19890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP2W18C05_19900	COG0539	negative regulation of cytoplasmic translation
WP2W18C05_19910	COG0776	regulation of translation
WP2W18C05_19930	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP2W18C05_19970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP2W18C05_19980	COG0602	queuosine metabolic process
WP2W18C05_19990	COG3530	Putative quorum-sensing-regulated virulence factor
WP2W18C05_20000	COG2096	Adenosyltransferase
WP2W18C05_20010	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2W18C05_20020	COG1757	Na H antiporter
WP2W18C05_20030	COG1435	thymidine kinase activity
WP2W18C05_20080	COG1349	DNA-binding transcription factor activity
WP2W18C05_20090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP2W18C05_20100	COG3550	peptidyl-serine autophosphorylation
WP2W18C05_20120	COG3385	transposase activity
WP2W18C05_20270	COG0629	single-stranded DNA binding
WP2W18C05_20310	COG3039	Transposase
WP2W18C05_20370	COG3039	Transposase
WP2W18C05_20380	COG3039	Transposase
WP2W18C05_20410	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18C05_20420	COG0542	response to heat
WP2W18C05_20440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2W18C05_20490	COG0501	Belongs to the peptidase M48B family
WP2W18C05_20500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18C05_20510	COG3039	Transposase
WP2W18C05_20550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP2W18C05_20580	COG1205	dead DEAH box helicase
WP2W18C05_20580	COG1111	helicase
WP2W18C05_20590	COG0210	DNA helicase
WP2W18C05_20680	COG2226	methyltransferase
WP2W18C05_20710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP2W18C05_20740	COG2910	NAD(P)H-binding
WP2W18C05_20750	COG0583	DNA-binding transcription factor activity
WP2W18C05_20760	COG4977	sequence-specific DNA binding
WP2W18C05_20760	COG1917	Cupin 2, conserved barrel domain protein
WP2W18C05_20770	COG2200	EAL domain
WP2W18C05_20780	COG3706	GGDEF domain
WP2W18C05_20790	COG4774	siderophore transport
WP2W18C05_20810	COG0583	DNA-binding transcription factor activity
WP2W18C05_20820	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP2W18C05_20840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2W18C05_20840	COG0617	tRNA 3'-terminal CCA addition
WP2W18C05_20840	COG0517	IMP dehydrogenase activity
WP2W18C05_20850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18C05_20860	COG3046	protein related to deoxyribodipyrimidine photolyase
WP2W18C05_20880	COG4235	cytochrome complex assembly
WP2W18C05_20880	COG3088	subunit of a heme lyase
WP2W18C05_20890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18C05_20900	COG1138	Cytochrome C-type biogenesis protein
WP2W18C05_20910	COG3301	Polysulphide reductase, NrfD
WP2W18C05_20920	COG0437	4 iron, 4 sulfur cluster binding
WP2W18C05_20930	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP2W18C05_20950	COG3385	transposase activity
WP2W18C05_21020	COG1846	Transcriptional regulator
WP2W18C05_21040	COG0500	methyltransferase
WP2W18C05_21060	COG2062	phosphohistidine phosphatase, SixA
WP2W18C05_21080	COG0697	spore germination
WP2W18C05_21100	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP2W18C05_21110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP2W18C05_21130	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2W18C05_21140	COG1136	(ABC) transporter
WP2W18C05_21150	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2W18C05_21160	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP2W18C05_21180	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP2W18C05_21190	COG0740	serine-type endopeptidase activity
WP2W18C05_21200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP2W18C05_21210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2W18C05_21220	COG0776	regulation of translation
WP2W18C05_21230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18C05_21240	COG0488	(ABC) transporter
WP2W18C05_21250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18C05_21260	COG3162	membrane
WP2W18C05_21290	COG1024	Enoyl-CoA hydratase
WP2W18C05_21300	COG1115	amino acid carrier protein
WP2W18C05_21320	COG3228	Belongs to the MtfA family
WP2W18C05_21330	COG1584	GPR1 FUN34 yaaH family protein
WP2W18C05_21350	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP2W18C05_21430	COG1024	Enoyl-CoA hydratase
WP2W18C05_21440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP2W18C05_21450	COG1960	acyl-CoA dehydrogenase activity
WP2W18C05_21470	COG1960	acyl-CoA dehydrogenase activity
WP2W18C05_21480	COG1024	Enoyl-CoA hydratase
WP2W18C05_21490	COG1024	Enoyl-CoA hydratase
WP2W18C05_21510	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18C05_21530	COG0730	response to heat
WP2W18C05_21550	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18C05_21560	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18C05_21570	COG1129	ABC transporter
WP2W18C05_21580	COG1879	ABC-type sugar transport system periplasmic component
WP2W18C05_21590	COG0583	DNA-binding transcription factor activity
WP2W18C05_21610	COG0583	DNA-binding transcription factor activity
WP2W18C05_21620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP2W18C05_21630	COG0243	molybdopterin cofactor binding
WP2W18C05_21650	COG0583	DNA-binding transcription factor activity
WP2W18C05_21660	COG2723	6-phospho-beta-galactosidase activity
WP2W18C05_21680	COG0583	DNA-binding transcription factor activity
WP2W18C05_21710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP2W18C05_21720	COG0673	inositol 2-dehydrogenase activity
WP2W18C05_21730	COG0583	DNA-binding transcription factor activity
WP2W18C05_21750	COG1560	Kdo2-lipid A biosynthetic process
WP2W18C05_21760	COG1560	Kdo2-lipid A biosynthetic process
WP2W18C05_21790	COG0417	DNA replication proofreading
WP2W18C05_21800	COG0534	Mate efflux family protein
WP2W18C05_21820	COG0307	riboflavin synthase, alpha
WP2W18C05_21850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18C05_21860	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP2W18C05_21870	COG0697	spore germination
WP2W18C05_21880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2W18C05_21930	COG2996	Protein conserved in bacteria
WP2W18C05_21960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2W18C05_21970	COG3099	Belongs to the UPF0263 family
WP2W18C05_21980	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP2W18C05_21990	COG2894	cell division
WP2W18C05_22000	COG0850	regulation of cytokinetic process
WP2W18C05_22010	COG3100	YcgL domain-containing protein
WP2W18C05_22020	COG2951	lytic endotransglycosylase activity
WP2W18C05_22030	COG1760	l-serine dehydratase
WP2W18C05_22040	COG1760	l-serine dehydratase
WP2W18C05_22050	COG3123	guanosine phosphorylase activity
WP2W18C05_22090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP2W18C05_22100	COG2067	long-chain fatty acid transport protein
WP2W18C05_22110	COG2067	long-chain fatty acid transport protein
WP2W18C05_22130	COG1595	DNA-templated transcription, initiation
WP2W18C05_22190	COG0714	Associated with various cellular activities
WP2W18C05_22200	COG0183	Belongs to the thiolase family
WP2W18C05_22210	COG1024	Enoyl-CoA hydratase
WP2W18C05_22210	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18C05_22230	COG4681	YaeQ
WP2W18C05_22270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18C05_22300	COG3134	Outer membrane lipoprotein
WP2W18C05_22310	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18C05_22320	COG2378	regulation of single-species biofilm formation
WP2W18C05_22340	COG0140	phosphoribosyl-ATP diphosphatase activity
WP2W18C05_22340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP2W18C05_22350	COG0107	imidazoleglycerol-phosphate synthase activity
WP2W18C05_22360	COG2205	protein histidine kinase activity
WP2W18C05_22360	COG2198	Histidine kinase
WP2W18C05_22360	COG0784	Response regulator, receiver
WP2W18C05_22380	COG3437	response regulator, receiver
WP2W18C05_22390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP2W18C05_22400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP2W18C05_22410	COG0131	Imidazoleglycerol-phosphate dehydratase
WP2W18C05_22410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2W18C05_22420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP2W18C05_22430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP2W18C05_22440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP2W18C05_22460	COG1199	ATP-dependent helicase activity
WP2W18C05_22470	COG1214	PFAM Peptidase M22, glycoprotease
WP2W18C05_22490	COG0596	Alpha beta hydrolase
WP2W18C05_22500	COG0318	PFAM AMP-dependent synthetase and ligase
WP2W18C05_22530	COG0697	spore germination
WP2W18C05_22550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2W18C05_22560	COG2832	Protein of unknown function (DUF454)
WP2W18C05_22570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP2W18C05_22590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP2W18C05_22610	COG3039	Transposase
WP2W18C05_22620	COG2801	Transposase and inactivated derivatives
WP2W18C05_22640	COG0583	DNA-binding transcription factor activity
WP2W18C05_22670	COG2197	response regulator
WP2W18C05_22680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2W18C05_22680	COG0517	IMP dehydrogenase activity
WP2W18C05_22680	COG0617	tRNA 3'-terminal CCA addition
WP2W18C05_22690	COG1643	Atp-dependent helicase
WP2W18C05_22710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP2W18C05_22730	COG3437	response regulator, receiver
WP2W18C05_22740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18C05_22750	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP2W18C05_22760	COG0709	Synthesizes selenophosphate from selenide and ATP
WP2W18C05_22800	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2W18C05_22810	COG0840	transmembrane signaling receptor activity
WP2W18C05_22820	COG1254	Belongs to the acylphosphatase family
WP2W18C05_22840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18C05_22840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18C05_22850	COG0489	protein tyrosine kinase activity
WP2W18C05_22860	COG0572	uridine kinase
WP2W18C05_22870	COG0717	Belongs to the dCTP deaminase family
WP2W18C05_22880	COG0306	phosphate transporter
WP2W18C05_22890	COG1530	ribonuclease E activity
WP2W18C05_22900	COG0564	pseudouridine synthase activity
WP2W18C05_22930	COG1399	metal-binding, possibly nucleic acid-binding protein
WP2W18C05_22940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP2W18C05_22950	COG0416	fatty acid biosynthetic process
WP2W18C05_22960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP2W18C05_22980	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18C05_22990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP2W18C05_23000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2W18C05_23010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP2W18C05_23020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP2W18C05_23030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP2W18C05_23040	COG0470	DNA polymerase III
WP2W18C05_23050	COG0084	hydrolase, TatD family'
WP2W18C05_23080	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP2W18C05_23080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18C05_23090	COG3008	intermembrane lipid transfer
WP2W18C05_23100	COG2995	paraquat-inducible protein a
WP2W18C05_23120	COG3141	response to X-ray
WP2W18C05_23150	COG1067	ATP-dependent peptidase activity
WP2W18C05_23160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2W18C05_23200	COG0116	Belongs to the methyltransferase superfamily
WP2W18C05_23200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2W18C05_23220	COG0167	dihydroorotate dehydrogenase activity
WP2W18C05_23230	COG2902	Dehydrogenase
WP2W18C05_23250	COG0308	aminopeptidase N
WP2W18C05_23270	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP2W18C05_23280	COG1956	GAF domain-containing protein
WP2W18C05_23300	COG3278	Belongs to the heme-copper respiratory oxidase family
WP2W18C05_23330	COG2010	Cytochrome c
WP2W18C05_23350	COG2217	Heavy metal translocating P-type atpase
WP2W18C05_23380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18C05_23390	COG0589	response to stress
WP2W18C05_23400	COG0037	tRNA processing
WP2W18C05_23430	COG0625	glutathione transferase activity
WP2W18C05_23440	COG1869	D-ribose catabolic process
WP2W18C05_23450	COG1129	ABC transporter
WP2W18C05_23460	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18C05_23470	COG1879	ABC-type sugar transport system periplasmic component
WP2W18C05_23480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18C05_23490	COG1609	Transcriptional regulator
WP2W18C05_23500	COG3300	MHYT domain
WP2W18C05_23500	COG5001	Diguanylate cyclase
WP2W18C05_23560	COG0776	regulation of translation
WP2W18C05_23570	COG0072	phenylalanine-tRNA ligase activity
WP2W18C05_23570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18C05_23580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP2W18C05_23590	COG4974	Belongs to the 'phage' integrase family
WP2W18C05_23620	COG3385	transposase activity
WP2W18C05_23750	COG3385	transposase activity
WP2W18C05_23790	COG4695	Portal protein
WP2W18C05_24000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WP2W18C05_24060	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
WP2W18C05_24070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP2W18C05_24080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP2W18C05_24090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP2W18C05_24100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP2W18C05_24160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18C05_24180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18C05_24190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2W18C05_24200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2W18C05_24210	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP2W18C05_24220	COG3313	Fe-S protein
WP2W18C05_24230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18C05_24230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP2W18C05_24230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2W18C05_24240	COG1105	Belongs to the carbohydrate kinase PfkB family
WP2W18C05_24250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_24250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_24260	COG1609	Transcriptional regulator
WP2W18C05_24270	COG0814	amino acid
WP2W18C05_24290	COG5654	RES domain protein
WP2W18C05_24300	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_24320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP2W18C05_24330	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2W18C05_24340	COG2840	Smr protein MutS2
WP2W18C05_24410	COG2824	Alkylphosphonate utilization operon protein PhnA
WP2W18C05_24430	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_24490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2W18C05_24500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
WP2W18C05_24550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2W18C05_24570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2W18C05_24600	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP2W18C05_24620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18C05_24630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP2W18C05_24650	COG0205	6-phosphofructokinase activity
WP2W18C05_24660	COG1473	amidohydrolase
WP2W18C05_24680	COG1473	amidohydrolase
WP2W18C05_24690	COG1473	amidohydrolase
WP2W18C05_24700	COG1011	Hydrolase
WP2W18C05_24710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2W18C05_24730	COG3593	DNA synthesis involved in DNA repair
WP2W18C05_24760	COG0583	DNA-binding transcription factor activity
WP2W18C05_24770	COG0730	response to heat
WP2W18C05_24790	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP2W18C05_24810	COG0386	Belongs to the glutathione peroxidase family
WP2W18C05_24820	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_24850	COG1742	UPF0060 membrane protein
WP2W18C05_24910	COG2329	Antibiotic biosynthesis monooxygenase
WP2W18C05_24920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP2W18C05_24960	COG3243	poly(R)-hydroxyalkanoic acid synthase
WP2W18C05_24980	COG2501	S4 domain
WP2W18C05_25010	COG1132	(ABC) transporter
WP2W18C05_25020	COG1132	(ABC) transporter
WP2W18C05_25040	COG3118	belongs to the thioredoxin family
WP2W18C05_25050	COG0471	metal ion transport
WP2W18C05_25070	COG0058	SHG alpha-glucan phosphorylase activity
WP2W18C05_25140	COG0814	amino acid
WP2W18C05_25150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP2W18C05_25160	COG0514	ATP-dependent DNA helicase (RecQ)
WP2W18C05_25170	COG2766	serine protein kinase
WP2W18C05_25180	COG2718	Belongs to the UPF0229 family
WP2W18C05_25190	COG2719	SpoVR family
WP2W18C05_25200	COG2186	Transcriptional regulator
WP2W18C05_25210	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2W18C05_25220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP2W18C05_25230	COG0586	Pfam SNARE associated Golgi protein
WP2W18C05_25250	COG0556	nucleotide-excision repair
WP2W18C05_25260	COG2985	domain, Protein
WP2W18C05_25260	COG0569	domain protein
WP2W18C05_25270	COG0739	heme binding
WP2W18C05_25270	COG0741	lytic transglycosylase activity
WP2W18C05_25270	COG1196	nuclear chromosome segregation
WP2W18C05_25280	COG3181	Tripartite tricarboxylate transporter family receptor
WP2W18C05_25310	COG4565	transcriptional regulatory protein
WP2W18C05_25320	COG3290	protein histidine kinase activity
WP2W18C05_25330	COG1846	Transcriptional regulator
WP2W18C05_25330	COG1940	carbohydrate kinase activity
WP2W18C05_25340	COG0840	transmembrane signaling receptor activity
WP2W18C05_25350	COG3012	SEC-C Motif Domain Protein
WP2W18C05_25360	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP2W18C05_25370	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP2W18C05_25390	COG0247	lactate metabolic process
WP2W18C05_25420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2W18C05_25420	COG0519	Catalyzes the synthesis of GMP from XMP
WP2W18C05_25430	COG0516	GMP reductase activity
WP2W18C05_25430	COG0517	IMP dehydrogenase activity
WP2W18C05_25450	COG1874	Beta-galactosidase
WP2W18C05_25450	COG0366	Alpha amylase catalytic
WP2W18C05_25500	COG1570	exodeoxyribonuclease VII activity
WP2W18C05_25520	COG2885	chlorophyll binding
WP2W18C05_25560	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP2W18C05_25580	COG3768	UPF0283 membrane protein
WP2W18C05_25590	COG3106	COG3106 Predicted ATPase
WP2W18C05_25620	COG1842	Phage shock protein A
WP2W18C05_25630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP2W18C05_25670	COG4171	peptide transport system, permease
WP2W18C05_25700	COG4172	Belongs to the ABC transporter superfamily
WP2W18C05_25720	COG1609	Transcriptional regulator
WP2W18C05_25730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18C05_25730	COG1263	PTS System
WP2W18C05_25740	COG2723	6-phospho-beta-galactosidase activity
WP2W18C05_25750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP2W18C05_25760	COG1286	toxin biosynthetic process
WP2W18C05_25770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP2W18C05_25780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP2W18C05_25790	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP2W18C05_25800	COG1674	ftsk spoiiie
WP2W18C05_25800	COG0531	amino acid
WP2W18C05_25820	COG0686	Belongs to the AlaDH PNT family
WP2W18C05_25830	COG0492	ferredoxin-NADP+ reductase activity
WP2W18C05_25840	COG3706	GGDEF domain
WP2W18C05_25850	COG3134	Outer membrane lipoprotein
WP2W18C05_25860	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP2W18C05_25870	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP2W18C05_25880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP2W18C05_25890	COG0542	response to heat
WP2W18C05_25900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP2W18C05_25910	COG1278	Cold shock
WP2W18C05_25920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2W18C05_25930	COG2076	Multidrug Resistance protein
WP2W18C05_25960	COG1944	ATP diphosphatase activity
WP2W18C05_25970	COG2116	formate transmembrane transporter activity
WP2W18C05_25980	COG1882	Formate acetyltransferase
WP2W18C05_25990	COG2983	Belongs to the UPF0260 family
WP2W18C05_26010	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WP2W18C05_26020	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2W18C05_26030	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18C05_26040	COG0567	Dehydrogenase, E1 component
WP2W18C05_26070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP2W18C05_26080	COG2009	succinate dehydrogenase
WP2W18C05_26120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2W18C05_26130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18C05_26130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP2W18C05_26150	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2W18C05_26180	COG1451	nucleotide metabolic process
WP2W18C05_26210	COG0254	rRNA binding
WP2W18C05_26220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP2W18C05_26240	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2W18C05_26250	COG1129	ABC transporter
WP2W18C05_26260	COG1879	ABC-type sugar transport system periplasmic component
WP2W18C05_26270	COG1069	ribulokinase activity
WP2W18C05_26290	COG2160	L-arabinose isomerase activity
WP2W18C05_26300	COG0583	DNA-binding transcription factor activity
WP2W18C05_26310	COG0436	Aminotransferase
WP2W18C05_26320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2W18C05_26350	COG0392	lysyltransferase activity
WP2W18C05_26350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP2W18C05_26360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2W18C05_26730	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
WP2W18C05_26780	COG1846	Transcriptional regulator
WP2W18C05_26810	COG1396	sequence-specific DNA binding
WP2W18C05_26870	COG2314	TM2 domain
WP2W18C05_26970	COG0629	single-stranded DNA binding
WP2W18C05_26990	COG0582	viral genome integration into host DNA
WP2W18C05_27000	COG2925	Exonuclease
WP2W18C05_27020	COG3345	alpha-galactosidase
WP2W18C05_27030	COG1380	Effector of murein hydrolase LrgA
WP2W18C05_27040	COG1346	cytolysis
WP2W18C05_27050	COG0295	cytidine deaminase activity
WP2W18C05_27060	COG1022	Amp-dependent synthetase and ligase
WP2W18C05_27090	COG0861	Integral membrane protein TerC family
WP2W18C05_27100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18C05_27110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP2W18C05_27120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP2W18C05_27200	COG4771	TonB-dependent receptor
WP2W18C05_27210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18C05_27220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2W18C05_27230	COG1120	ATPase activity
WP2W18C05_27260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18C05_27280	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18C05_27290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2W18C05_27300	COG1535	isochorismatase
WP2W18C05_27300	COG3433	isochorismatase activity
WP2W18C05_27310	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP2W18C05_27360	COG5001	Diguanylate cyclase
WP2W18C05_27360	COG3300	MHYT domain
WP2W18C05_27390	COG0840	transmembrane signaling receptor activity
WP2W18C05_27400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18C05_27410	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP2W18C05_27420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP2W18C05_27430	COG0563	adenylate kinase activity
WP2W18C05_27440	COG0326	Molecular chaperone. Has ATPase activity
WP2W18C05_27450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP2W18C05_27470	COG3158	transport of potassium into the cell
WP2W18C05_27480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP2W18C05_27490	COG0298	carbon dioxide binding
WP2W18C05_27510	COG0309	Hydrogenase expression formation protein (HypE)
WP2W18C05_27520	COG0375	protein maturation
WP2W18C05_27540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP2W18C05_27550	COG3842	ATPase activity
WP2W18C05_27560	COG0444	Belongs to the ABC transporter superfamily
WP2W18C05_27570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18C05_27580	COG0601	transmembrane transport
WP2W18C05_27600	COG1773	rubredoxin
WP2W18C05_27610	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP2W18C05_27620	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP2W18C05_27630	COG5557	Pfam Polysulphide reductase, NrfD
WP2W18C05_27640	COG0437	4 iron, 4 sulfur cluster binding
WP2W18C05_27650	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP2W18C05_27680	COG3501	Rhs element vgr protein
WP2W18C05_27860	COG3415	Transposase
WP2W18C05_27860	COG2801	Transposase and inactivated derivatives
WP2W18C05_27870	COG3385	transposase activity
WP2W18C05_27890	COG3209	COG3209 Rhs family protein
WP2W18C05_27910	COG3501	Rhs element vgr protein
WP2W18C05_27980	COG3385	transposase activity
WP2W18C05_27990	COG3385	transposase activity
WP2W18C05_28030	COG0659	secondary active sulfate transmembrane transporter activity
WP2W18C05_28050	COG0300	oxidoreductase activity
WP2W18C05_28060	COG2308	Evidence 4 Homologs of previously reported genes of
WP2W18C05_28130	COG0672	)-iron permease
WP2W18C05_28180	COG2814	Major facilitator Superfamily
WP2W18C05_28230	COG1136	(ABC) transporter
WP2W18C05_28300	COG1139	Iron-sulfur cluster binding protein
WP2W18C05_28310	COG0247	lactate metabolic process
WP2W18C05_28320	COG1620	l-lactate permease
WP2W18C05_28330	COG0583	DNA-binding transcription factor activity
WP2W18C05_28380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2W18C05_28390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP2W18C05_28390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2W18C05_28400	COG0527	aspartate kinase activity
WP2W18C05_28420	COG1368	sulfuric ester hydrolase activity
WP2W18C05_28430	COG0393	Putative heavy-metal-binding
WP2W18C05_28450	COG1252	NADH dehydrogenase
WP2W18C05_28460	COG3150	esterase
WP2W18C05_28470	COG1164	Oligoendopeptidase f
WP2W18C05_28480	COG1164	Oligoendopeptidase f
WP2W18C05_28490	COG2354	Protein conserved in bacteria
WP2W18C05_28520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18C05_28530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2W18C05_28600	COG0537	adenosine 5'-monophosphoramidase activity
WP2W18C05_28630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP2W18C05_28650	COG1301	dicarboxylic acid transport
WP2W18C05_28670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2W18C05_28680	COG0861	Integral membrane protein TerC family
WP2W18C05_28700	COG0444	Belongs to the ABC transporter superfamily
WP2W18C05_28710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18C05_28720	COG0601	transmembrane transport
WP2W18C05_28740	COG2095	MarC family integral membrane protein
WP2W18C05_28750	COG1454	alcohol dehydrogenase
WP2W18C05_28750	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_28770	COG3275	phosphorelay sensor kinase activity
WP2W18C05_28780	COG3279	Response regulator of the LytR AlgR family
WP2W18C05_28790	COG1966	Carbon starvation protein
WP2W18C05_28800	COG3264	Mechanosensitive ion channel
WP2W18C05_28800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP2W18C05_28820	COG1566	PFAM secretion protein HlyD family protein
WP2W18C05_28830	COG1061	Type III restriction enzyme res subunit
WP2W18C05_28840	COG2027	D-alanyl-D-alanine carboxypeptidase
WP2W18C05_28850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP2W18C05_28870	COG0436	Aminotransferase
WP2W18C05_28880	COG1288	antiporter activity
WP2W18C05_28890	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP2W18C05_28930	COG0697	spore germination
WP2W18C05_28940	COG4657	Part of a membrane complex involved in electron transport
WP2W18C05_28950	COG2878	Part of a membrane complex involved in electron transport
WP2W18C05_28970	COG4658	electron transport chain
WP2W18C05_28980	COG4659	FMN binding
WP2W18C05_28990	COG4660	Part of a membrane complex involved in electron transport
WP2W18C05_29000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP2W18C05_29010	COG0346	lactoylglutathione lyase activity
WP2W18C05_29020	COG0840	transmembrane signaling receptor activity
WP2W18C05_29050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP2W18C05_29070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP2W18C05_29080	COG1086	Polysaccharide biosynthesis protein
WP2W18C05_29090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP2W18C05_29110	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
WP2W18C05_29120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP2W18C05_29150	COG2089	acid synthase
WP2W18C05_29210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP2W18C05_29250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18C05_29250	COG0301	tRNA thio-modification
WP2W18C05_29270	COG4953	penicillin-binding protein 1C
WP2W18C05_29280	COG2373	Large extracellular alpha-helical protein
WP2W18C05_29300	COG0628	permease
WP2W18C05_29350	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18C05_29370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2W18C05_29390	COG4160	amino acid transport
WP2W18C05_29410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_29430	COG2431	L-lysine efflux transmembrane transporter activity
WP2W18C05_29440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2W18C05_29450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_29500	COG1393	Belongs to the ArsC family
WP2W18C05_29520	COG4783	chaperone-mediated protein folding
WP2W18C05_29530	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18C05_29560	COG0596	Alpha beta hydrolase
WP2W18C05_29580	COG3842	ATPase activity
WP2W18C05_29590	COG3833	ABC-type maltose transport systems, permease component
WP2W18C05_29600	COG1175	transmembrane transport
WP2W18C05_29620	COG3081	Nucleoid-associated protein
WP2W18C05_29630	COG3082	Protein of unknown function (DUF1414)
WP2W18C05_29640	COG3083	sulfuric ester hydrolase activity
WP2W18C05_29650	COG4771	TonB-dependent receptor
WP2W18C05_29660	COG1770	oligopeptidase
WP2W18C05_29700	COG4574	serine-type endopeptidase inhibitor activity
WP2W18C05_29710	COG3085	chromosome segregation
WP2W18C05_29730	COG1605	Chorismate mutase
WP2W18C05_29730	COG0287	Prephenate dehydrogenase
WP2W18C05_29740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2W18C05_29750	COG0584	glycerophosphoryl diester phosphodiesterase
WP2W18C05_29770	COG1349	DNA-binding transcription factor activity
WP2W18C05_29780	COG2271	Major facilitator Superfamily
WP2W18C05_29790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2W18C05_29800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP2W18C05_29810	COG0583	DNA-binding transcription factor activity
WP2W18C05_29850	COG0656	L-ascorbic acid biosynthetic process
WP2W18C05_29860	COG2814	Major facilitator Superfamily
WP2W18C05_29880	COG1294	oxidase, subunit
WP2W18C05_29890	COG1271	oxidase subunit
WP2W18C05_29900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18C05_29920	COG2979	Protein of unknown function (DUF533)
WP2W18C05_29960	COG0583	DNA-binding transcription factor activity
WP2W18C05_29980	COG2807	transmembrane transport
WP2W18C05_29990	COG1187	pseudouridine synthase activity
WP2W18C05_30000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WP2W18C05_30030	COG1403	HNH endonuclease
WP2W18C05_30080	COG1166	arginine decarboxylase activity
WP2W18C05_30090	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2W18C05_30120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP2W18C05_30150	COG0583	DNA-binding transcription factor activity
WP2W18C05_30170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP2W18C05_30180	COG0840	transmembrane signaling receptor activity
WP2W18C05_30190	COG0302	gtp cyclohydrolase
WP2W18C05_30210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2W18C05_30240	COG2267	carboxylic ester hydrolase activity
WP2W18C05_30250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP2W18C05_30280	COG0314	molybdopterin synthase activity
WP2W18C05_30290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP2W18C05_30300	COG0315	cyclic pyranopterin monophosphate synthase activity
WP2W18C05_30310	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2W18C05_30320	COG3005	denitrification pathway
WP2W18C05_30340	COG0348	domain, Protein
WP2W18C05_30350	COG0437	4 iron, 4 sulfur cluster binding
WP2W18C05_30360	COG0243	molybdopterin cofactor binding
WP2W18C05_30380	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18C05_30380	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18C05_30390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP2W18C05_30400	COG3850	Histidine kinase
WP2W18C05_30410	COG2197	response regulator
WP2W18C05_30460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
WP2W18C05_30480	COG0121	glutamine amidotransferase
WP2W18C05_30490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2W18C05_30500	COG1960	acyl-CoA dehydrogenase activity
WP2W18C05_30510	COG3437	response regulator, receiver
WP2W18C05_30510	COG0784	Response regulator, receiver
WP2W18C05_30530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2W18C05_30540	COG0328	RNA-DNA hybrid ribonuclease activity
WP2W18C05_30550	COG2226	methyltransferase
WP2W18C05_30560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2W18C05_30570	COG1388	LysM domain
WP2W18C05_30570	COG0741	lytic transglycosylase activity
WP2W18C05_30600	COG1607	acyl-coa hydrolase
WP2W18C05_30630	COG0741	lytic transglycosylase activity
WP2W18C05_30650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP2W18C05_30670	COG2911	Protein conserved in bacteria
WP2W18C05_30680	COG0729	surface antigen
WP2W18C05_30700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2W18C05_30720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2W18C05_30730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18C05_30740	COG4134	Bacterial extracellular solute-binding protein
WP2W18C05_30760	COG4136	ATPase activity
WP2W18C05_30770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP2W18C05_30780	COG2951	lytic endotransglycosylase activity
WP2W18C05_30790	COG1846	Transcriptional regulator
WP2W18C05_30810	COG0033	Phosphoglucomutase
WP2W18C05_30820	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP2W18C05_30830	COG0596	Alpha beta hydrolase
WP2W18C05_30860	COG0716	FMN binding
WP2W18C05_30880	COG0735	belongs to the Fur family
WP2W18C05_30890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18C05_30910	COG1263	PTS System
WP2W18C05_30910	COG2190	(PTS) system
WP2W18C05_30910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18C05_30920	COG0363	glucosamine-6-phosphate deaminase activity
WP2W18C05_30930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2W18C05_30940	COG1846	Transcriptional regulator
WP2W18C05_30940	COG1940	carbohydrate kinase activity
WP2W18C05_30950	COG2194	sulfuric ester hydrolase activity
WP2W18C05_30960	COG0217	transcriptional regulatory protein
WP2W18C05_30970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP2W18C05_30980	COG1801	Protein of unknown function DUF72
WP2W18C05_30990	COG4106	trans-aconitate 2-methyltransferase activity
WP2W18C05_31000	COG0500	methyltransferase
WP2W18C05_31040	COG0583	DNA-binding transcription factor activity
WP2W18C05_31050	COG0791	NLP P60 protein
WP2W18C05_31080	COG1309	transcriptional regulator
WP2W18C05_31100	COG1454	alcohol dehydrogenase
WP2W18C05_31150	COG0534	Mate efflux family protein
WP2W18C05_31180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP2W18C05_31180	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP2W18C05_31180	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP2W18C05_31180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP2W18C05_31200	COG0633	Ferredoxin
WP2W18C05_31200	COG3217	Mosc domain protein beta barrel domain protein
WP2W18C05_31200	COG3217	Mosc domain protein beta barrel domain protein
WP2W18C05_31200	COG0633	Ferredoxin
WP2W18C05_31210	COG0501	Belongs to the peptidase M48B family
WP2W18C05_31220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP2W18C05_31230	COG1073	alpha beta
WP2W18C05_31230	COG2226	methyltransferase
WP2W18C05_31240	COG0156	8-amino-7-oxononanoate synthase activity
WP2W18C05_31250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2W18C05_31290	COG0017	Asparaginyl-tRNA synthetase
WP2W18C05_31300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2W18C05_31320	COG1473	amidohydrolase
WP2W18C05_31330	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2W18C05_31350	COG1393	Belongs to the ArsC family
WP2W18C05_31360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP2W18C05_31370	COG1876	peptidase activity
WP2W18C05_31390	COG3263	regulation of cellular component size
WP2W18C05_31410	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_31460	COG1957	nucleoside hydrolase
WP2W18C05_31490	COG1454	alcohol dehydrogenase
WP2W18C05_31500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18C05_31510	COG0702	epimerase
WP2W18C05_31530	COG2867	negative regulation of translational initiation
WP2W18C05_31540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP2W18C05_31550	COG0582	viral genome integration into host DNA
WP2W18C05_31610	COG4735	regulation of single-species biofilm formation
WP2W18C05_31680	COG0800	Aldolase
WP2W18C05_31710	COG3153	acetyltransferase
WP2W18C05_31770	COG0259	pyridoxamine-phosphate oxidase activity
WP2W18C05_31810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18C05_31810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2W18C05_31820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP2W18C05_31850	COG0457	Tetratricopeptide repeat
WP2W18C05_31870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2W18C05_31880	COG1138	Cytochrome C-type biogenesis protein
WP2W18C05_31890	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP2W18C05_31900	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18C05_31910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18C05_31920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2W18C05_31950	COG0835	chemotaxis
WP2W18C05_31970	COG1192	Involved in chromosome partitioning
WP2W18C05_31980	COG1360	Flagellar Motor Protein
WP2W18C05_31990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18C05_32000	COG2201	protein-glutamate methylesterase activity
WP2W18C05_32010	COG0784	Response regulator, receiver
WP2W18C05_32010	COG2198	Histidine kinase
WP2W18C05_32010	COG0643	Histidine kinase
WP2W18C05_32020	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP2W18C05_32070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP2W18C05_32090	COG1684	flagellar biosynthetic protein fliR
WP2W18C05_32210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP2W18C05_32230	COG1677	Flagellar hook-basal body complex protein FliE
WP2W18C05_32260	COG1393	Belongs to the ArsC family
WP2W18C05_32270	COG0798	PFAM Bile acid sodium symporter
WP2W18C05_32280	COG0640	Transcriptional regulator
WP2W18C05_32290	COG3385	transposase activity
WP2W18C05_32310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2W18C05_32340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2W18C05_32350	COG0444	Belongs to the ABC transporter superfamily
WP2W18C05_32360	COG4608	Belongs to the ABC transporter superfamily
WP2W18C05_32380	COG2971	BadF BadG BcrA BcrD
WP2W18C05_32400	COG0840	transmembrane signaling receptor activity
WP2W18C05_32440	COG3724	N-succinylarginine dihydrolase activity
WP2W18C05_32450	COG0616	signal peptide processing
WP2W18C05_32460	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18C05_32470	COG0583	DNA-binding transcription factor activity
WP2W18C05_32490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP2W18C05_32510	COG0583	DNA-binding transcription factor activity
WP2W18C05_32530	COG1881	PFAM PEBP family protein
WP2W18C05_32550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2W18C05_32560	COG0739	heme binding
WP2W18C05_32570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP2W18C05_32600	COG3385	transposase activity
WP2W18C05_32610	COG3385	transposase activity
WP2W18C05_32650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP2W18C05_32670	COG3091	SprT-like family
WP2W18C05_32690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP2W18C05_32700	COG0189	ligase activity
WP2W18C05_32720	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP2W18C05_32760	COG1115	amino acid carrier protein
WP2W18C05_32770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP2W18C05_32800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP2W18C05_32820	COG1301	dicarboxylic acid transport
WP2W18C05_32830	COG3385	transposase activity
WP2W18C05_32840	COG3385	transposase activity
WP2W18C05_32860	COG0471	metal ion transport
WP2W18C05_32860	COG0490	domain, Protein
WP2W18C05_32910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18C05_32940	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_32960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP2W18C05_32990	COG0180	Tryptophanyl-tRNA synthetase
WP2W18C05_33010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP2W18C05_33020	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP2W18C05_33040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP2W18C05_33050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP2W18C05_33110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP2W18C05_33120	COG0583	DNA-binding transcription factor activity
WP2W18C05_33150	COG0583	DNA-binding transcription factor activity
WP2W18C05_33180	COG3121	Chaperone
WP2W18C05_33190	COG3188	usher protein
WP2W18C05_33210	COG3121	Chaperone
WP2W18C05_33230	COG0739	heme binding
WP2W18C05_33250	COG3264	Mechanosensitive ion channel
WP2W18C05_33250	COG1511	domain protein
WP2W18C05_33260	COG0584	glycerophosphoryl diester phosphodiesterase
WP2W18C05_33280	COG1053	succinate dehydrogenase
WP2W18C05_33290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP2W18C05_33300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2W18C05_33310	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2W18C05_33340	COG3214	Protein conserved in bacteria
WP2W18C05_33350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2W18C05_33390	COG0300	oxidoreductase activity
WP2W18C05_33450	COG4067	protein conserved in archaea
WP2W18C05_33450	COG0189	ligase activity
WP2W18C05_33460	COG0516	GMP reductase activity
WP2W18C05_33480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP2W18C05_33490	COG2011	ABC-type metal ion transport system permease component
WP2W18C05_33500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2W18C05_33510	COG1464	Belongs to the NlpA lipoprotein family
WP2W18C05_33540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2W18C05_33560	COG2199	diguanylate cyclase activity
WP2W18C05_33590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18C05_33620	COG1335	isochorismatase
WP2W18C05_33630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2W18C05_33640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2W18C05_33650	COG1702	phosphate starvation-inducible protein PhoH
WP2W18C05_33660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP2W18C05_33670	COG4535	Mg2 and Co2 transporter CorC
WP2W18C05_33680	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP2W18C05_33690	COG2888	peptidyl-tyrosine sulfation
WP2W18C05_33700	COG0495	leucyl-tRNA aminoacylation
WP2W18C05_33730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP2W18C05_33740	COG0799	negative regulation of ribosome biogenesis
WP2W18C05_33750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP2W18C05_33760	COG0768	penicillin binding
WP2W18C05_33770	COG0772	Belongs to the SEDS family
WP2W18C05_33780	COG2951	lytic endotransglycosylase activity
WP2W18C05_33790	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2W18C05_33800	COG1686	Belongs to the peptidase S11 family
WP2W18C05_33810	COG2921	Belongs to the UPF0250 family
WP2W18C05_33820	COG0321	lipoyl(octanoyl) transferase activity
WP2W18C05_33840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP2W18C05_33860	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2W18C05_33890	COG0789	Transcriptional regulator
WP2W18C05_33900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WP2W18C05_33920	COG1970	mechanosensitive ion channel activity
WP2W18C05_33930	COG4974	Belongs to the 'phage' integrase family
WP2W18C05_33950	COG0312	modulator of DNA gyrase
WP2W18C05_33960	COG0312	modulator of DNA gyrase
WP2W18C05_34000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2W18C05_34010	COG1422	Protein of unknown function (DUF1090)
WP2W18C05_34020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2W18C05_34030	COG2211	Major facilitator Superfamily
WP2W18C05_34040	COG1185	polyribonucleotide nucleotidyltransferase activity
WP2W18C05_34050	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP2W18C05_34060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP2W18C05_34070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP2W18C05_34080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP2W18C05_34090	COG0195	Participates in both transcription termination and antitermination
WP2W18C05_34100	COG0779	Required for maturation of 30S ribosomal subunits
WP2W18C05_34110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP2W18C05_34120	COG0149	triose-phosphate isomerase activity
WP2W18C05_34130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP2W18C05_34140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP2W18C05_34160	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP2W18C05_34170	COG1534	Rna-binding protein
WP2W18C05_34200	COG1360	Flagellar Motor Protein
WP2W18C05_34210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18C05_34220	COG1722	exodeoxyribonuclease VII activity
WP2W18C05_34230	COG0142	geranyltranstransferase activity
WP2W18C05_34240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP2W18C05_34280	COG4172	Belongs to the ABC transporter superfamily
WP2W18C05_34290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP2W18C05_34300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP2W18C05_34310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2W18C05_34320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP2W18C05_34350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18C05_34350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2W18C05_34360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP2W18C05_34380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP2W18C05_34400	COG3381	protein complex oligomerization
WP2W18C05_34440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18C05_34450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP2W18C05_34460	COG0511	ligase activity, forming carbon-carbon bonds
WP2W18C05_34470	COG0439	Biotin carboxylase
WP2W18C05_34480	COG3924	membrane
WP2W18C05_34490	COG4145	pantothenate transmembrane transporter activity
WP2W18C05_34500	COG2190	(PTS) system
WP2W18C05_34500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18C05_34500	COG1263	PTS System
WP2W18C05_34510	COG0583	DNA-binding transcription factor activity
WP2W18C05_34520	COG0604	alcohol dehydrogenase
WP2W18C05_34530	COG2264	protein methyltransferase activity
WP2W18C05_34570	COG0778	Nitroreductase
WP2W18C05_34580	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18C05_34580	COG1902	pentaerythritol trinitrate reductase activity
WP2W18C05_34590	COG0616	signal peptide processing
WP2W18C05_34630	COG3139	Protein of unknown function (DUF1315)
WP2W18C05_34640	COG0252	asparaginase activity
WP2W18C05_34650	COG0786	glutamate:sodium symporter activity
WP2W18C05_34670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP2W18C05_34680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP2W18C05_34690	COG0384	phenazine biosynthesis protein PhzF
WP2W18C05_34700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP2W18C05_34710	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18C05_34720	COG0175	sulfate reduction
WP2W18C05_34730	COG2113	Glycine betaine
WP2W18C05_34740	COG4176	ABC-type proline glycine betaine transport system permease component
WP2W18C05_34750	COG4175	Glycine betaine
WP2W18C05_34770	COG3610	response to peptide
WP2W18C05_34780	COG2966	Psort location CytoplasmicMembrane, score
WP2W18C05_34800	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2W18C05_34840	COG2313	pseudouridylate synthase activity
WP2W18C05_34850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2W18C05_34860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18C05_34860	COG2146	nitrite reductase [NAD(P)H] activity
WP2W18C05_34870	COG2146	nitrite reductase [NAD(P)H] activity
WP2W18C05_34870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18C05_34880	COG1116	anion transmembrane transporter activity
WP2W18C05_34890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WP2W18C05_34900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WP2W18C05_34900	COG1116	anion transmembrane transporter activity
WP2W18C05_34920	COG1648	precorrin-2 dehydrogenase activity
WP2W18C05_34920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18C05_34930	COG0243	molybdopterin cofactor binding
WP2W18C05_34980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP2W18C05_35020	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP2W18C05_35040	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2W18C05_35060	COG4608	Belongs to the ABC transporter superfamily
WP2W18C05_35070	COG0444	Belongs to the ABC transporter superfamily
WP2W18C05_35090	COG4239	(ABC) transporter, permease
WP2W18C05_35100	COG4174	ABC transporter (Permease)
WP2W18C05_35110	COG4206	TonB-dependent receptor
WP2W18C05_35130	COG0811	peptide transport
WP2W18C05_35140	COG0811	peptide transport
WP2W18C05_35150	COG0848	biopolymer transport protein
WP2W18C05_35220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18C05_35230	COG0840	transmembrane signaling receptor activity
WP2W18C05_35250	COG1278	Cold shock
WP2W18C05_35260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP2W18C05_35270	COG1162	GTPase activity
WP2W18C05_35280	COG0688	phosphatidylethanolamine metabolic process
WP2W18C05_35290	COG4628	conserved protein (DUF2132)
WP2W18C05_35330	COG5001	Diguanylate cyclase
WP2W18C05_35330	COG3300	MHYT domain
WP2W18C05_35340	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP2W18C05_35370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WP2W18C05_35370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WP2W18C05_35430	COG4974	Belongs to the 'phage' integrase family
WP2W18C05_35480	COG0582	viral genome integration into host DNA
WP2W18C05_35520	COG1132	(ABC) transporter
WP2W18C05_35580	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18C05_35590	COG2897	thiosulfate sulfurtransferase activity
WP2W18C05_35600	COG2066	Belongs to the glutaminase family
WP2W18C05_35610	COG3171	Protein conserved in bacteria
WP2W18C05_35620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP2W18C05_35630	COG2234	aminopeptidase activity
WP2W18C05_35650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2W18C05_35660	COG2200	EAL domain
WP2W18C05_35670	COG1090	epimerase
WP2W18C05_35680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP2W18C05_35690	COG4181	ATPase activity
WP2W18C05_35700	COG2755	lipolytic protein G-D-S-L family
WP2W18C05_35710	COG0835	chemotaxis
WP2W18C05_35710	COG0784	Response regulator, receiver
WP2W18C05_35730	COG0517	IMP dehydrogenase activity
WP2W18C05_35730	COG0516	GMP reductase activity
WP2W18C05_35740	COG0488	(ABC) transporter
WP2W18C05_35760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP2W18C05_35850	COG0789	Transcriptional regulator
WP2W18C05_35870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2W18C05_35890	COG0668	transmembrane transport
WP2W18C05_35910	COG2731	YhcH YjgK YiaL family protein
WP2W18C05_35930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18C05_35940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18C05_35950	COG3227	Zinc metalloprotease (Elastase)
WP2W18C05_35960	COG0583	DNA-binding transcription factor activity
WP2W18C05_35970	COG0477	Major facilitator Superfamily
WP2W18C05_35990	COG0569	domain protein
WP2W18C05_35990	COG2985	domain, Protein
WP2W18C05_36000	COG1272	protein, Hemolysin III
WP2W18C05_36010	COG0076	glutamate decarboxylase activity
WP2W18C05_36020	COG2917	probably involved in intracellular septation
WP2W18C05_36030	COG2350	Protein conserved in bacteria
WP2W18C05_36050	COG1555	photosystem II stabilization
WP2W18C05_36060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP2W18C05_36070	COG3104	oligopeptide transport
WP2W18C05_36080	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_36140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_36170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP2W18C05_36180	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_36190	COG0316	Belongs to the HesB IscA family
WP2W18C05_36210	COG0038	chloride channel
WP2W18C05_36220	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP2W18C05_36250	COG0671	phosphoesterase, PA-phosphatase related
WP2W18C05_36270	COG0583	DNA-binding transcription factor activity
WP2W18C05_36300	COG0346	lactoylglutathione lyase activity
WP2W18C05_36310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2W18C05_36320	COG1643	Atp-dependent helicase
WP2W18C05_36340	COG1489	DNA binding
WP2W18C05_36350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP2W18C05_36360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2W18C05_36380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP2W18C05_36390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP2W18C05_36400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP2W18C05_36420	COG0842	Transport permease protein
WP2W18C05_36430	COG1131	(ABC) transporter
WP2W18C05_36460	COG0163	prenyltransferase activity
WP2W18C05_36470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2W18C05_36480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP2W18C05_36510	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP2W18C05_36540	COG1136	(ABC) transporter
WP2W18C05_36580	COG0840	transmembrane signaling receptor activity
WP2W18C05_36640	COG0529	Catalyzes the synthesis of activated sulfate
WP2W18C05_36650	COG0471	metal ion transport
WP2W18C05_36650	COG3273	potassium ion transport
WP2W18C05_36660	COG2895	sulfate adenylyltransferase (ATP) activity
WP2W18C05_36670	COG0175	sulfate reduction
WP2W18C05_36680	COG1648	precorrin-2 dehydrogenase activity
WP2W18C05_36680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18C05_36690	COG0330	HflC and HflK could
WP2W18C05_36700	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP2W18C05_36720	COG0673	inositol 2-dehydrogenase activity
WP2W18C05_36740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP2W18C05_36750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2W18C05_36760	COG3036	rescue of stalled ribosome
WP2W18C05_36790	COG0138	bifunctional purine biosynthesis protein purh
WP2W18C05_36850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP2W18C05_36860	COG0358	DNA primase activity
WP2W18C05_36870	COG1610	YqeY-like protein
WP2W18C05_36880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP2W18C05_36890	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP2W18C05_36910	COG1388	LysM domain
WP2W18C05_36910	COG4942	peptidase
WP2W18C05_36920	COG1238	metal cluster binding
WP2W18C05_36930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP2W18C05_36940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP2W18C05_36950	COG0585	pseudouridine synthase activity
WP2W18C05_36970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP2W18C05_36980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP2W18C05_36990	COG0148	phosphopyruvate hydratase activity
WP2W18C05_37000	COG0504	CTP synthase activity
WP2W18C05_37010	COG3956	TIGRFAM MazG family protein
WP2W18C05_37020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2W18C05_37030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18C05_37050	COG4807	Protein conserved in bacteria
WP2W18C05_37060	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP2W18C05_37070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP2W18C05_37080	COG1381	Involved in DNA repair and RecF pathway recombination
WP2W18C05_37100	COG0571	ribonuclease III activity
WP2W18C05_37110	COG0681	Belongs to the peptidase S26 family
WP2W18C05_37120	COG0481	GTPase activity
WP2W18C05_37150	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP2W18C05_37160	COG1595	DNA-templated transcription, initiation
WP2W18C05_37170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP2W18C05_37190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP2W18C05_37200	COG0354	folic acid binding
WP2W18C05_37210	COG0583	DNA-binding transcription factor activity
WP2W18C05_37280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2W18C05_37300	COG0126	phosphoglycerate kinase activity
WP2W18C05_37310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2W18C05_37320	COG1940	carbohydrate kinase activity
WP2W18C05_37330	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP2W18C05_37350	COG4991	sh3 domain protein
WP2W18C05_37360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2W18C05_37390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP2W18C05_37400	COG1028	Short-chain dehydrogenase reductase Sdr
WP2W18C05_37420	COG1505	serine-type exopeptidase activity
WP2W18C05_37430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2W18C05_37440	COG0765	amino acid transport
WP2W18C05_37470	COG0765	amino acid transport
WP2W18C05_37480	COG1126	abc transporter atp-binding protein
WP2W18C05_37490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2W18C05_37500	COG3174	membrane
WP2W18C05_37510	COG0110	maltose O-acetyltransferase activity
WP2W18C05_37570	COG1942	4-Oxalocrotonate Tautomerase
WP2W18C05_37590	COG0583	DNA-binding transcription factor activity
WP2W18C05_37600	COG0165	Argininosuccinate lyase
WP2W18C05_37610	COG0137	argininosuccinate synthase activity
WP2W18C05_37630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2W18C05_37640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP2W18C05_37660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP2W18C05_37670	COG5001	Diguanylate cyclase
WP2W18C05_37670	COG3447	MASE1 domain protein
WP2W18C05_37670	COG5002	protein histidine kinase activity
WP2W18C05_37680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP2W18C05_37750	COG0583	DNA-binding transcription factor activity
WP2W18C05_37760	COG1380	Effector of murein hydrolase LrgA
WP2W18C05_37770	COG1346	cytolysis
WP2W18C05_37780	COG0460	homoserine dehydrogenase
WP2W18C05_37780	COG0527	aspartate kinase activity
WP2W18C05_37790	COG0626	cystathionine gamma-synthase activity
WP2W18C05_37820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2W18C05_37830	COG0814	amino acid
WP2W18C05_37840	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP2W18C05_37850	COG0494	nUDIX hydrolase
WP2W18C05_37860	COG1011	Hydrolase
WP2W18C05_37870	COG1902	pentaerythritol trinitrate reductase activity
WP2W18C05_37890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2W18C05_37920	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP2W18C05_37940	COG3156	type II secretion system protein K
WP2W18C05_37950	COG4795	General secretion pathway protein
WP2W18C05_37960	COG2165	general secretion pathway protein
WP2W18C05_37980	COG2165	general secretion pathway protein
WP2W18C05_37990	COG1459	type II secretion system
WP2W18C05_38000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2W18C05_38020	COG3031	protein transport across the cell outer membrane
WP2W18C05_38040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP2W18C05_38050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
WP2W18C05_38080	COG0456	acetyltransferase
WP2W18C05_38090	COG3133	Outer membrane lipoprotein
WP2W18C05_38100	COG3025	triphosphatase activity
WP2W18C05_38110	COG1392	Phosphate transport regulator
WP2W18C05_38120	COG0306	phosphate transporter
WP2W18C05_38130	COG0617	tRNA 3'-terminal CCA addition
WP2W18C05_38140	COG3409	Peptidoglycan-binding domain 1 protein
WP2W18C05_38140	COG3267	Type II secretory pathway component ExeA
WP2W18C05_38160	COG1194	a g-specific adenine glycosylase
WP2W18C05_38170	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP2W18C05_38200	COG3240	lipase activity
WP2W18C05_38220	COG3009	Protein conserved in bacteria
WP2W18C05_38230	COG3008	intermembrane lipid transfer
WP2W18C05_38230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2W18C05_38240	COG2995	paraquat-inducible protein a
WP2W18C05_38260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2W18C05_38270	COG5001	Diguanylate cyclase
WP2W18C05_38270	COG3706	GGDEF domain
WP2W18C05_38270	COG4251	negative regulation of phosphorylation
WP2W18C05_38270	COG2203	Gaf domain
WP2W18C05_38280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2W18C05_38290	COG2813	Specifically methylates the guanine in position
WP2W18C05_38300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP2W18C05_38310	COG3385	transposase activity
WP2W18C05_38320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP2W18C05_38330	COG0297	glycogen (starch) synthase activity
WP2W18C05_38360	COG1757	Na H antiporter
WP2W18C05_38370	COG0583	DNA-binding transcription factor activity
WP2W18C05_38380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP2W18C05_38390	COG3842	ATPase activity
WP2W18C05_38400	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2W18C05_38410	COG1177	transmembrane transport
WP2W18C05_38420	COG1012	belongs to the aldehyde dehydrogenase family
WP2W18C05_38430	COG0109	protoheme IX farnesyltransferase activity
WP2W18C05_38490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
WP2W18C05_38510	COG1565	acr, cog1565
WP2W18C05_38510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP2W18C05_38520	COG1444	tRNA N-acetyltransferase activity
WP2W18C05_38560	COG1803	Methylglyoxal synthase
WP2W18C05_38590	COG0252	asparaginase activity
WP2W18C05_38630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2W18C05_38630	COG1263	PTS System
WP2W18C05_38640	COG0366	Alpha amylase catalytic
WP2W18C05_38650	COG0110	maltose O-acetyltransferase activity
WP2W18C05_38660	COG1522	sequence-specific DNA binding
WP2W18C05_38840	COG2314	TM2 domain
WP2W18C05_38920	COG3422	double-strand break repair
WP2W18C05_38940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP2W18C05_38950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP2W18C05_38980	COG0477	Major facilitator Superfamily
WP2W18C05_38990	COG0523	cobalamin synthesis protein
WP2W18C05_39010	COG1280	lysine exporter protein (LysE YggA)
WP2W18C05_39030	COG2200	EAL domain
WP2W18C05_39040	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP2W18C05_39050	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2W18C05_39060	COG0840	transmembrane signaling receptor activity
WP2W18C05_39070	COG0840	transmembrane signaling receptor activity
WP2W18C05_39090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2W18C05_39100	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2W18C05_39110	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP2W18C05_39120	COG2186	Transcriptional regulator
WP2W18C05_39160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2W18C05_39170	COG1459	type II secretion system
WP2W18C05_39180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WP2W18C05_39200	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP2W18C05_39210	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP2W18C05_39220	COG0494	nUDIX hydrolase
WP2W18C05_39240	COG0653	protein targeting
WP2W18C05_39260	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP2W18C05_39270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP2W18C05_39280	COG0849	cell division
WP2W18C05_39290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WP2W18C05_39300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2W18C05_39310	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP2W18C05_39320	COG0772	Belongs to the SEDS family
WP2W18C05_39330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP2W18C05_39340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP2W18C05_39350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP2W18C05_39360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP2W18C05_39370	COG0768	penicillin binding
WP2W18C05_39380	COG3116	cell division
WP2W18C05_39390	COG0275	rRNA processing
WP2W18C05_39400	COG2001	Belongs to the MraZ family
WP2W18C05_39430	COG0741	lytic transglycosylase activity
WP2W18C05_39430	COG1388	LysM domain
WP2W18C05_39450	COG1360	Flagellar Motor Protein
WP2W18C05_39460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2W18C05_39470	COG1191	sigma factor activity
WP2W18C05_39520	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
WP2W18C05_39530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP2W18C05_39540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP2W18C05_39580	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP2W18C05_39590	COG4786	Flagellar basal body rod
WP2W18C05_39590	COG1256	bacterial-type flagellum assembly
WP2W18C05_39610	COG1706	bacterial-type flagellum-dependent cell motility
WP2W18C05_39620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP2W18C05_39630	COG4786	Flagellar basal body rod
WP2W18C05_39650	COG1749	Flagellar hook protein flgE
WP2W18C05_39680	COG1815	bacterial-type flagellum-dependent cell motility
WP2W18C05_39690	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP2W18C05_39750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP2W18C05_39770	COG1677	Flagellar hook-basal body complex protein FliE
WP2W18C05_39820	COG1987	bacterial-type flagellum assembly
WP2W18C05_39860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP2W18C05_39870	COG3107	peptidoglycan biosynthetic process
WP2W18C05_39880	COG0792	nuclease activity
WP2W18C05_39890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2W18C05_39900	COG2823	Periplasmic or secreted lipoprotein
WP2W18C05_39910	COG2969	positive regulation of protein catabolic process
WP2W18C05_39920	COG0625	glutathione transferase activity
WP2W18C05_39930	COG2857	Cytochrome c1
WP2W18C05_39940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP2W18C05_39950	COG0723	plastoquinol--plastocyanin reductase activity
WP2W18C05_39960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP2W18C05_39970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP2W18C05_39980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP2W18C05_40000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18C05_40010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2W18C05_40070	COG3964	amidohydrolase
WP2W18C05_40110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_40120	COG1660	Displays ATPase and GTPase activities
WP2W18C05_40130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2W18C05_40150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP2W18C05_40160	COG1137	ATPase activity
WP2W18C05_40170	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP2W18C05_40190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP2W18C05_40200	COG0517	IMP dehydrogenase activity
WP2W18C05_40200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP2W18C05_40210	COG1127	ABC transporter
WP2W18C05_40220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP2W18C05_40230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2W18C05_40240	COG2854	intermembrane phospholipid transfer
WP2W18C05_40260	COG5007	Belongs to the BolA IbaG family
WP2W18C05_40270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP2W18C05_40280	COG0312	modulator of DNA gyrase
WP2W18C05_40290	COG3028	Belongs to the UPF0307 family
WP2W18C05_40310	COG2926	Belongs to the UPF0265 family
WP2W18C05_40340	COG1396	sequence-specific DNA binding
WP2W18C05_40350	COG3135	benzoate transporter
WP2W18C05_40410	COG3047	cAMP biosynthetic process
WP2W18C05_40440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP2W18C05_40450	COG2197	response regulator
WP2W18C05_40520	COG1278	Cold shock
WP2W18C05_40530	COG2205	protein histidine kinase activity
WP2W18C05_40540	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_40580	COG3706	GGDEF domain
WP2W18C05_40590	COG0347	Belongs to the P(II) protein family
WP2W18C05_40600	COG0004	ammonium transporteR
WP2W18C05_40620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2W18C05_40630	COG1074	ATP-dependent DNA helicase activity
WP2W18C05_40640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP2W18C05_40650	COG2259	Doxx family
WP2W18C05_40660	COG1741	Belongs to the pirin family
WP2W18C05_40680	COG0583	DNA-binding transcription factor activity
WP2W18C05_40740	COG1175	transmembrane transport
WP2W18C05_40760	COG3842	ATPase activity
WP2W18C05_40820	COG0456	acetyltransferase
WP2W18C05_40830	COG0753	catalase activity
WP2W18C05_40870	COG0494	nUDIX hydrolase
WP2W18C05_40880	COG0628	permease
WP2W18C05_40900	COG2957	Belongs to the agmatine deiminase family
WP2W18C05_40930	COG2957	Belongs to the agmatine deiminase family
WP2W18C05_40940	COG0583	DNA-binding transcription factor activity
WP2W18C05_40970	COG1461	Dihydroxyacetone kinase
WP2W18C05_40980	COG2376	Dihydroxyacetone kinase
WP2W18C05_40990	COG2252	PERMEase
WP2W18C05_41000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
WP2W18C05_41010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2W18C05_41020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18C05_41030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP2W18C05_41040	COG0049	tRNA binding
WP2W18C05_41050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP2W18C05_41060	COG2168	tRNA wobble position uridine thiolation
WP2W18C05_41080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2W18C05_41090	COG0251	oxidation-reduction process
WP2W18C05_41100	COG2964	Protein conserved in bacteria
WP2W18C05_41110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP2W18C05_41120	COG0085	RNA polymerase activity
WP2W18C05_41130	COG0222	ribosome binding
WP2W18C05_41140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP2W18C05_41150	COG0081	regulation of translation
WP2W18C05_41160	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP2W18C05_41170	COG0250	Participates in transcription elongation, termination and antitermination
WP2W18C05_41190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2W18C05_41220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP2W18C05_41230	COG0569	domain protein
WP2W18C05_41240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18C05_41250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP2W18C05_41260	COG3005	denitrification pathway
WP2W18C05_41270	COG0243	molybdopterin cofactor binding
WP2W18C05_41300	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_41340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP2W18C05_41370	COG2204	response regulator
WP2W18C05_41390	COG2205	protein histidine kinase activity
WP2W18C05_41430	COG4109	DRTGG domain
WP2W18C05_41450	COG1522	sequence-specific DNA binding
WP2W18C05_41460	COG2502	aspartate--ammonia ligase
WP2W18C05_41470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2W18C05_41480	COG0542	response to heat
WP2W18C05_41500	COG0564	pseudouridine synthase activity
WP2W18C05_41510	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2W18C05_41520	COG3681	Belongs to the UPF0597 family
WP2W18C05_41530	COG2964	Protein conserved in bacteria
WP2W18C05_41540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP2W18C05_41550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP2W18C05_41560	COG1979	alcohol dehydrogenase
WP2W18C05_41570	COG2207	Transcriptional regulator
WP2W18C05_41580	COG3040	lipid binding
WP2W18C05_41620	COG0583	DNA-binding transcription factor activity
WP2W18C05_41650	COG0540	Belongs to the ATCase OTCase family
WP2W18C05_41660	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP2W18C05_41670	COG1438	arginine binding
WP2W18C05_41690	COG1288	antiporter activity
WP2W18C05_41700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP2W18C05_41780	COG3250	beta-galactosidase activity
WP2W18C05_41790	COG1609	Transcriptional regulator
WP2W18C05_41800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2W18C05_41820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP2W18C05_41830	COG2017	converts alpha-aldose to the beta-anomer
WP2W18C05_41840	COG0667	Aldo Keto reductase
WP2W18C05_41850	COG1968	undecaprenyl-diphosphatase activity
WP2W18C05_41860	COG3806	Anti-sigma factor
WP2W18C05_41870	COG1595	DNA-templated transcription, initiation
WP2W18C05_41910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP2W18C05_41920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP2W18C05_41930	COG0477	Major facilitator Superfamily
WP2W18C05_41970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2W18C05_41980	COG1131	(ABC) transporter
WP2W18C05_41990	COG0842	Transport permease protein
WP2W18C05_42000	COG0842	Transport permease protein
WP2W18C05_42010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2W18C05_42040	COG2116	formate transmembrane transporter activity
WP2W18C05_42050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2W18C05_42050	COG1648	precorrin-2 dehydrogenase activity
WP2W18C05_42060	COG2239	Acts as a magnesium transporter
WP2W18C05_42070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2W18C05_42080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP2W18C05_42100	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP2W18C05_42120	COG0514	ATP-dependent DNA helicase (RecQ)
WP2W18C05_42130	COG2050	protein possibly involved in aromatic compounds catabolism
WP2W18C05_42150	COG2258	MOSC domain
WP2W18C05_42160	COG1177	transmembrane transport
WP2W18C05_42170	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2W18C05_42180	COG3842	ATPase activity
WP2W18C05_42220	COG0174	glutamine synthetase
WP2W18C05_42260	COG3045	CreA protein
WP2W18C05_42270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2W18C05_42280	COG0443	Heat shock 70 kDa protein
WP2W18C05_42310	COG0366	Alpha amylase catalytic
WP2W18C05_42340	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2W18C05_42350	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_42370	COG2205	protein histidine kinase activity
WP2W18C05_42390	COG0281	malic enzyme
WP2W18C05_42400	COG0702	epimerase
WP2W18C05_42410	COG0254	rRNA binding
WP2W18C05_42420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP2W18C05_42430	COG1309	transcriptional regulator
WP2W18C05_42470	COG0129	dihydroxy-acid dehydratase activity
WP2W18C05_42490	COG3978	acetolactate synthase activity
WP2W18C05_42510	COG0606	chelatase, subunit chli
WP2W18C05_42520	COG0204	Acyl-transferase
WP2W18C05_42530	COG0204	Acyl-transferase
WP2W18C05_42540	COG1683	Conserved Protein
WP2W18C05_42560	COG1335	isochorismatase
WP2W18C05_42580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2W18C05_42590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP2W18C05_42610	COG3084	Protein conserved in bacteria
WP2W18C05_42620	COG2203	Gaf domain
WP2W18C05_42620	COG5001	Diguanylate cyclase
WP2W18C05_42620	COG4251	negative regulation of phosphorylation
WP2W18C05_42620	COG3706	GGDEF domain
WP2W18C05_42650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP2W18C05_42660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP2W18C05_42670	COG1561	YicC-like family, N-terminal region
WP2W18C05_42690	COG1519	Transferase
WP2W18C05_42700	COG0859	PFAM glycosyl transferase family 9
WP2W18C05_42710	COG0463	Glycosyl transferase, family 2
WP2W18C05_42720	COG0859	PFAM glycosyl transferase family 9
WP2W18C05_42730	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP2W18C05_42740	COG2990	Protein conserved in bacteria
WP2W18C05_42750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP2W18C05_42770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP2W18C05_42780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP2W18C05_42790	COG2003	Belongs to the UPF0758 family
WP2W18C05_42800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP2W18C05_42810	COG0756	dUTP diphosphatase activity
WP2W18C05_42820	COG1309	transcriptional regulator
WP2W18C05_42830	COG0668	transmembrane transport
WP2W18C05_42850	COG0166	Belongs to the GPI family
WP2W18C05_42860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP2W18C05_42870	COG0583	DNA-binding transcription factor activity
WP2W18C05_42890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2W18C05_42890	COG1042	CoA-binding domain protein
WP2W18C05_42890	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2W18C05_42900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP2W18C05_42910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18C05_42910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2W18C05_42920	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP2W18C05_42930	COG3074	FtsZ-dependent cytokinesis
WP2W18C05_42950	COG1045	serine acetyltransferase
WP2W18C05_42970	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_42980	COG2205	protein histidine kinase activity
WP2W18C05_42990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP2W18C05_43000	COG0534	Mate efflux family protein
WP2W18C05_43030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2W18C05_43040	COG2937	Belongs to the GPAT DAPAT family
WP2W18C05_43050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP2W18C05_43060	COG3161	chorismate lyase activity
WP2W18C05_43070	COG1580	Controls the rotational direction of flagella during chemotaxis
WP2W18C05_43110	COG1609	Transcriptional regulator
WP2W18C05_43180	COG3307	-O-antigen
WP2W18C05_43200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2W18C05_43220	COG0156	8-amino-7-oxononanoate synthase activity
WP2W18C05_43240	COG1063	alcohol dehydrogenase
WP2W18C05_43280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP2W18C05_43290	COG2166	iron-sulfur cluster assembly
WP2W18C05_43300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP2W18C05_43320	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP2W18C05_43330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2W18C05_43340	COG1739	Uncharacterized protein family UPF0029
WP2W18C05_43350	COG0006	proline dipeptidase activity
WP2W18C05_43360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2W18C05_43370	COG1024	Enoyl-CoA hydratase
WP2W18C05_43370	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2W18C05_43380	COG0183	Belongs to the thiolase family
WP2W18C05_43390	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_43430	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18C05_43440	COG0425	Belongs to the sulfur carrier protein TusA family
WP2W18C05_43450	COG0251	oxidation-reduction process
WP2W18C05_43460	COG2885	chlorophyll binding
WP2W18C05_43480	COG1335	isochorismatase
WP2W18C05_43490	COG2818	Glycosylase
WP2W18C05_43500	COG0752	glycyl-tRNA synthetase alpha subunit
WP2W18C05_43510	COG0751	glycine-tRNA ligase activity
WP2W18C05_43530	COG5001	Diguanylate cyclase
WP2W18C05_43530	COG4251	negative regulation of phosphorylation
WP2W18C05_43530	COG3706	GGDEF domain
WP2W18C05_43530	COG2203	Gaf domain
WP2W18C05_43570	COG0814	amino acid
WP2W18C05_43580	COG0814	amino acid
WP2W18C05_43590	COG3033	Beta-eliminating lyase
WP2W18C05_43610	COG0348	domain, Protein
WP2W18C05_43640	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2W18C05_43650	COG1773	rubredoxin
WP2W18C05_43650	COG0426	domain, Protein
WP2W18C05_43660	COG3604	Transcriptional regulator
WP2W18C05_43670	COG1609	Transcriptional regulator
WP2W18C05_43750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2W18C05_43790	COG2960	long-chain fatty acid transporting porin activity
WP2W18C05_43810	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP2W18C05_43840	COG3118	belongs to the thioredoxin family
WP2W18C05_43850	COG0513	Belongs to the DEAD box helicase family
WP2W18C05_43860	COG0248	Ppx GppA phosphatase
WP2W18C05_43880	COG0742	ribosomal rna small subunit methyltransferase
WP2W18C05_43900	COG0339	signal peptide processing
WP2W18C05_43920	COG0084	hydrolase, TatD family'
WP2W18C05_43930	COG0805	protein transport
WP2W18C05_43940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18C05_43950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2W18C05_43960	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP2W18C05_43970	COG3165	ubiquinone biosynthetic process from chorismate
WP2W18C05_43990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP2W18C05_44000	COG0402	S-adenosylhomocysteine deaminase activity
WP2W18C05_44030	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP2W18C05_44040	COG0848	biopolymer transport protein
WP2W18C05_44050	COG0811	peptide transport
WP2W18C05_44060	COG0811	peptide transport
WP2W18C05_44080	COG2771	luxR family
WP2W18C05_44090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP2W18C05_44100	COG1349	DNA-binding transcription factor activity
WP2W18C05_44110	COG0745	RESPONSE REGULATOR receiver
WP2W18C05_44120	COG2205	protein histidine kinase activity
WP2W18C05_44140	COG4452	Inner membrane protein CreD
WP2W18C05_44150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP2W18C05_44160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP2W18C05_44170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP2W18C05_44180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP2W18C05_44190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP2W18C05_44200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP2W18C05_44210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP2W18C05_44230	COG0356	it plays a direct role in the translocation of protons across the membrane
WP2W18C05_44250	COG1475	DNA binding
WP2W18C05_44260	COG1192	Involved in chromosome partitioning
WP2W18C05_44270	COG0357	Ribosomal RNA small subunit methyltransferase G
WP2W18C05_44280	COG0445	tRNA wobble uridine modification
WP2W18C05_44290	COG0716	FMN binding
WP2W18C05_44300	COG4774	siderophore transport
WP2W18C05_44310	COG4615	Cyclic peptide transporter
WP2W18C05_44320	COG1120	ATPase activity
WP2W18C05_44330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP2W18C05_44350	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP2W18C05_44360	COG0706	membrane insertase activity
WP2W18C05_44370	COG0594	ribonuclease P activity
WP2W18C05_44380	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP2W18C05_P10030	COG1192	Involved in chromosome partitioning
WP2W18C05_P10060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P10120	COG1192	Involved in chromosome partitioning
WP2W18C05_P10300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P10430	COG2176	DNA-directed DNA polymerase activity
WP2W18C05_P10430	COG5002	protein histidine kinase activity
WP2W18C05_P20020	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2W18C05_P20030	COG0542	response to heat
WP2W18C05_P20130	COG1192	Involved in chromosome partitioning
WP2W18C05_P20190	COG2176	DNA-directed DNA polymerase activity
WP2W18C05_P20190	COG5002	protein histidine kinase activity
WP2W18C05_P20320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P20330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P30040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P40150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2W18C05_P50110	COG3041	Addiction module toxin RelE StbE family
WP2W18C05_P50120	COG3077	Addiction module antitoxin, RelB DinJ family
WP2W18C05_P60120	COG1846	Transcriptional regulator