locus-tag	class	description
GIS01_00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
GIS01_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
GIS01_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
GIS01_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GIS01_00030	ENOG4105D29	Helix-turn-helix type 11 domain protein
GIS01_00035	ENOG4105ECQ	AraC Family Transcriptional Regulator
GIS01_00040	ENOG4105IGJ	Zn-dependent Hydrolase of the beta-lactamase fold protein
GIS01_00045	ENOG4108ZNX	Heat shock protein
GIS01_00050	ENOG4108ZNX	Heat shock protein
GIS01_00065	ENOG4105JKW	Valine--pyruvate aminotransferase
GIS01_00080	ENOG4105C2C	drug resistance transporter, Bcr CflA
GIS01_00085	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
GIS01_00090	ENOG4105C08	Histidine kinase
GIS01_00100	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
GIS01_00105	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
GIS01_00115	ENOG4105DC8	reductase
GIS01_00120	ENOG4105BZU	Histidine kinase
GIS01_00125	ENOG4105BZS	acriflavin resistance protein
GIS01_00130	ENOG410624X	efflux transporter, rnd family, mfp subunit
GIS01_00135	ENOG4105Y7M	Transcriptional regulator, TetR family
GIS01_00165	ENOG4105DQF	Hydrolase
GIS01_00170	ENOG4108EUD	Lysophospholipase
GIS01_00180	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
GIS01_00185	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
GIS01_00190	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
GIS01_00195	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
GIS01_00205	ENOG4105DKP	glycosyl transferase, family 9
GIS01_00210	ENOG4108W7E	Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity)
GIS01_00220	ENOG4105EMK	carboxylate amino acid amine transporter
GIS01_00250	ENOG4108M6U	Universal stress protein A
GIS01_00255	ENOG4105RKW	reductase (By
GIS01_00260	ENOG41090A1	ferritin
GIS01_00265	ENOG4105CBX	hi0933 family
GIS01_00270	ENOG4108HRK	Histidine kinase
GIS01_00275	ENOG4105DY9	regulatoR
GIS01_00280	ENOG4105FCD	Major Facilitator
GIS01_00285	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
GIS01_00290	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
GIS01_00305	ENOG41063Z6	transcriptional regulator, lysR family
GIS01_00315	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
GIS01_00345	ENOG4105CUZ	uba thif-type nad fad binding protein
GIS01_00350	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
GIS01_00355	ENOG4105C9B	Cysteine desulfurase
GIS01_00360	ENOG4105C4R	Atp-dependent dna helicase
GIS01_00365	ENOG4105BZU	Histidine kinase
GIS01_00370	ENOG4105MPD	Cytochrome
GIS01_00375	ENOG4105CPQ	Dehydrogenase
GIS01_00380	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
GIS01_00385	ENOG41062JF	Transcriptional regulator
GIS01_00390	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
GIS01_00400	ENOG4105PF3	O-Antigen polymerase
GIS01_00465	ENOG41061EV	selenium-binding protein YdfZ
GIS01_00470	ENOG4108UK5	Transposase
GIS01_00480	ENOG4105M03	Domain of unknown function (DUF955)
GIS01_00495	ENOG4105C4R	Atp-dependent dna helicase
GIS01_00510	ENOG4105DIH	basic membrane
GIS01_00515	ENOG4108JQ9	ABC transporter
GIS01_00520	ENOG4105UIB	(ABC) transporter
GIS01_00530	ENOG4105CJW	magnesium transporter
GIS01_00535	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GIS01_00540	ENOG4107V9H	nitrite transporter
GIS01_00545	ENOG4105WZK	nitrite reductase NADPH small subunit
GIS01_00550	ENOG4107QZF	nitrite reductase NADPH large subunit
GIS01_00555	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
GIS01_00560	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
GIS01_00570	ENOG4105C75	arginyL-tRNA synthetase
GIS01_00580	ENOG4105K6V	RNA polymerase
GIS01_00590	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
GIS01_00595	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
GIS01_00600	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
GIS01_00605	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
GIS01_00610	ENOG4105CMR	udp-glucose 4-epimerase
GIS01_00615	ENOG41060NJ	transcriptional regulator
GIS01_00620	ENOG4105CNT	hydrolase family 2
GIS01_00630	ENOG4105C2J	ABC transporter
GIS01_00635	ENOG4108HWV	)-transporter
GIS01_00640	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_00645	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
GIS01_00660	ENOG4107R28	alpha amylase, catalytic region
GIS01_00675	ENOG4105R8A	Heat shock protein
GIS01_00680	ENOG4105C5I	Dehydrogenase
GIS01_00685	ENOG4108RH0	Crea protein
GIS01_00700	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_00705	ENOG4105CFQ	glutamine synthetase
GIS01_00710	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
GIS01_00720	ENOG4108HM4	ABC transporter
GIS01_00725	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_00730	ENOG4105F38	ABC transporter, permease
GIS01_00735	ENOG4105D38	putrescine abc transporter
GIS01_00740	ENOG4108RPX	mosc domain containing protein
GIS01_00755	ENOG4108VUY	thioesterase Superfamily protein
GIS01_00760	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GIS01_00765	ENOG4105N7H	Cytochrome
GIS01_00770	ENOG4105CNG	UPF0061 protein
GIS01_00780	ENOG4105EX9	Membrane
GIS01_00785	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
GIS01_00790	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_00800	ENOG4105VFB	Binds the 23S rRNA (By similarity)
GIS01_00805	ENOG4105C25	Primosomal protein n'
GIS01_00815	ENOG4105CGD	Nad-dependent epimerase dehydratase
GIS01_00820	ENOG4105CIC	tryptophan-specific transport protein
GIS01_00825	ENOG4105C6K	Malic enzyme
GIS01_00830	ENOG4107S2Z	UPF0761 membrane protein
GIS01_00835	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
GIS01_00840	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
GIS01_00845	ENOG4105SUU	thioesterase domain
GIS01_00855	ENOG4105CB5	ATP-dependent DNA helicase recG
GIS01_00860	ENOG4105JIM	Phosphatidylserine synthase
GIS01_00865	ENOG4105C6Z	Gluconate
GIS01_00870	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
GIS01_00875	ENOG4105C01	Dihydroxy-acid dehydratase
GIS01_00880	ENOG4108UHU	Aldolase
GIS01_00895	ENOG4105DIQ	Transcriptional regulator
GIS01_00905	ENOG41063SB	peptidase
GIS01_00910	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
GIS01_00915	ENOG4107YZP	Rhodanese domain protein
GIS01_00920	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
GIS01_00925	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
GIS01_00930	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
GIS01_00935	ENOG4105MJ2	Competence protein
GIS01_00940	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
GIS01_00960	ENOG4105BZM	domain protein
GIS01_00965	ENOG4108RRZ	Transcription elongation factor GreB
GIS01_00970	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GIS01_00975	ENOG4105E0F	Histidine kinase
GIS01_00985	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
GIS01_00990	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
GIS01_00995	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
GIS01_01000	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
GIS01_01005	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GIS01_01010	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
GIS01_01015	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
GIS01_01020	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
GIS01_01025	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
GIS01_01030	ENOG41083MP	50s ribosomal protein l29
GIS01_01035	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
GIS01_01040	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
GIS01_01045	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
GIS01_01050	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GIS01_01055	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
GIS01_01060	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
GIS01_01065	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
GIS01_01070	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
GIS01_01075	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
GIS01_01080	ENOG4105VPB	50S ribosomal protein L30
GIS01_01085	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
GIS01_01090	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
GIS01_01095	ENOG41067V7	50S ribosomal protein L36
GIS01_01100	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GIS01_01105	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
GIS01_01110	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
GIS01_01115	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GIS01_01120	ENOG4108ZT0	50S ribosomal protein l17
GIS01_01155	ENOG4105D05	Receptor
GIS01_01160	ENOG4105BZU	Histidine kinase
GIS01_01165	ENOG4105E0F	Histidine kinase
GIS01_01170	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GIS01_01190	ENOG4105CWB	LysR family transcriptional Regulator
GIS01_01200	ENOG4105C2I	pirin domain protein
GIS01_01205	ENOG4108VBZ	doxx family
GIS01_01210	ENOG4105DSY	exodeoxyribonuclease V, gamma
GIS01_01215	ENOG4107QKA	exodeoxyribonuclease V beta
GIS01_01220	ENOG4107QYX	exodeoxyribonuclease v alpha
GIS01_01230	ENOG4105BZU	Histidine kinase
GIS01_01260	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
GIS01_01270	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_01300	ENOG4108IQK	o-acetylhomoserine
GIS01_01310	ENOG4105KNR	Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)
GIS01_01315	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
GIS01_01335	ENOG4107IFA	Lipase (EC 3.1.1.3)
GIS01_01340	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GIS01_01345	ENOG4108UDW	Transcriptional regulator, luxr family
GIS01_01365	ENOG4105CH6	catalase
GIS01_01370	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
GIS01_01395	ENOG4105MYG	DNA polymerase iii, chi subunit
GIS01_01400	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
GIS01_01405	ENOG4108M8S	permease YjgP YjgQ family protein
GIS01_01410	ENOG4108K5H	permease YjgP YjgQ family protein
GIS01_01440	ENOG41061WM	D-Alanyl-D-Alanine
GIS01_01445	ENOG4107SC7	Inner membrane transporter yjeM
GIS01_01465	ENOG4105CBT	Fructose-1,6-bisphosphatase
GIS01_01480	ENOG4105ECF	c-methyltransferase
GIS01_01485	ENOG41076E6	Uroporphyrinogen-III Synthase
GIS01_01490	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
GIS01_01495	ENOG4107T0K	Adenylate cyclase
GIS01_01500	ENOG4106CJB	Phospholipase Carboxylesterase
GIS01_01505	ENOG4105XQ6	frataxin-like protein
GIS01_01515	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
GIS01_01520	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
GIS01_01530	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GIS01_01535	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
GIS01_01545	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
GIS01_01555	ENOG4108Z86	Glutamine amidotransferase
GIS01_01560	ENOG4105N42	UPF0307 protein
GIS01_01585	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GIS01_01660	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
GIS01_01665	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
GIS01_01670	ENOG4105VFK	BolA family
GIS01_01680	ENOG4105E3I	toluene tolerance
GIS01_01685	ENOG4107PE3	Mammalian cell entry related domain protein
GIS01_01690	ENOG4105CY3	ABC transporter, permease
GIS01_01695	ENOG4105DHJ	ABC, transporter
GIS01_01700	ENOG4105C2X	Arabinose 5-phosphate isomerase
GIS01_01705	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
GIS01_01710	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
GIS01_01715	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
GIS01_01720	ENOG4108IUZ	ABC transporter
GIS01_01725	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GIS01_01730	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
GIS01_01735	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
GIS01_01740	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
GIS01_01745	ENOG41080Z8	PHOSPHOCARRIER protein
GIS01_01765	ENOG41069H0	dihydroorotase EC 3.5.2.3
GIS01_01795	ENOG4105C0H	protease
GIS01_01800	ENOG4105C0H	protease
GIS01_01810	ENOG4105D6Z	AFG1 family ATPase
GIS01_01815	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
GIS01_01820	ENOG4108UJD	30S ribosomal protein S9
GIS01_01825	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GIS01_01830	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
GIS01_01835	ENOG4105EIX	cytochrome c1
GIS01_01840	ENOG4107MKT	Stringent starvation protein a
GIS01_01845	ENOG4105KB2	stringent starvation protein b
GIS01_01850	ENOG4105W4M	Transport-associated protein
GIS01_01855	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
GIS01_01860	ENOG41082RQ	UPF0102 protein
GIS01_01865	ENOG4105E1C	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)
GIS01_01870	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
GIS01_01885	ENOG4105DD5	Flagellar motor switch protein
GIS01_01890	ENOG4105CN7	Flagellar biosynthetic protein FliP
GIS01_01895	ENOG4105VS8	Flagellar biosynthetic protein fliq
GIS01_01900	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
GIS01_01905	ENOG4105D00	flagellar biosynthetic protein flhB
GIS01_01915	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_01920	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
GIS01_01925	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
GIS01_01930	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
GIS01_01940	ENOG4108JIR	Flagellum-specific ATP synthase
GIS01_01965	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
GIS01_01970	ENOG4108ZC9	flagellar basal-body rod protein flgc
GIS01_01975	ENOG4105W00	Flagellar hook capping protein
GIS01_01980	ENOG4105BZE	flagellar hook protein, FlgE
GIS01_01985	ENOG4108KPB	Flagellar basal-body rod protein FlgF
GIS01_01990	ENOG4105CGA	flagellar basal-body rod protein FlgG
GIS01_01995	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
GIS01_02000	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
GIS01_02015	ENOG4105DTJ	flagellar hook-associated protein
GIS01_02025	ENOG4105I03	Flagellin
GIS01_02030	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
GIS01_02035	ENOG4105MQ3	flagellar protein FliS
GIS01_02060	ENOG4107RD7	Flagellar Motor Protein, MotA
GIS01_02075	ENOG4105E9H	Lytic Murein transglycosylase
GIS01_02080	ENOG4108V6E	Cell division protein mraZ
GIS01_02085	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
GIS01_02090	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
GIS01_02095	ENOG4105CJN	penicillin-binding protein
GIS01_02100	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
GIS01_02105	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
GIS01_02110	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
GIS01_02115	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
GIS01_02120	ENOG4105CNI	cell division protein FtsW
GIS01_02125	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
GIS01_02130	ENOG4105DFU	Cell wall formation (By similarity)
GIS01_02135	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
GIS01_02140	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
GIS01_02145	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
GIS01_02150	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GIS01_02160	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
GIS01_02165	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GIS01_02170	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
GIS01_02175	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
GIS01_02185	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
GIS01_02190	ENOG4105D7Q	type ii secretion system
GIS01_02195	ENOG4107QHF	type ii secretion system protein e
GIS01_02205	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
GIS01_02220	ENOG41073TP	transcriptional regulator
GIS01_02225	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
GIS01_02230	ENOG4107QSN	dihydrolipoamide acetyltransferase
GIS01_02235	ENOG4107QN2	dihydrolipoyl dehydrogenase
GIS01_02240	ENOG4105BZU	Histidine kinase
GIS01_02245	ENOG4108N3W	hemolysin secretion protein
GIS01_02250	ENOG4105D78	K07001 NTE family protein
GIS01_02255	ENOG4107QIJ	Aconitate hydratase 2
GIS01_02260	ENOG4105BZU	Histidine kinase
GIS01_02270	ENOG4105CKI	cobalamin synthesis protein
GIS01_02275	ENOG4108IJF	Heavy metal efflux pump, CzcA
GIS01_02290	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
GIS01_02300	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GIS01_02305	ENOG4107ZVW	dihydroneopterin aldolase
GIS01_02310	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
GIS01_02335	ENOG4105DWD	nucleoside recognition domain protein
GIS01_02340	ENOG4105KWI	UPF0339 protein
GIS01_02385	ENOG4105YB8	TM2 domain containing protein
GIS01_02410	ENOG4105NI8	Cytosine-specific methyltransferase
GIS01_02415	ENOG4105DWD	nucleoside recognition domain protein
GIS01_02435	ENOG4105CH7	arginosuccinase
GIS01_02440	ENOG4105CDH	Citrulline--aspartate ligase
GIS01_02450	ENOG4105CAS	nag kinase
GIS01_02455	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
GIS01_02465	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
GIS01_02475	ENOG4108Z66	YbaK ebsC protein
GIS01_02485	ENOG4105CMU	LysR family (Transcriptional regulator
GIS01_02495	ENOG41067MG	lrgb family
GIS01_02505	ENOG4108NRW	Phospholipase, patatin family
GIS01_02510	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
GIS01_02515	ENOG4107TH8	cina domain protein
GIS01_02520	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
GIS01_02530	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GIS01_02535	ENOG4105CFH	Aspartokinase
GIS01_02540	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
GIS01_02575	ENOG41061WM	D-Alanyl-D-Alanine
GIS01_02580	ENOG4106W5V	Membrane
GIS01_02590	ENOG4105HDK	L-asparaginase
GIS01_02605	ENOG4105D4X	repressor
GIS01_02610	ENOG4105C5Y	PTS System
GIS01_02615	ENOG4105CG3	alpha amylase, catalytic region
GIS01_02620	ENOG4108UW5	maltose o-acetyltransferase
GIS01_02635	ENOG4105D3G	Pseudouridine synthase
GIS01_02640	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
GIS01_02670	ENOG41090HJ	UPF0265 protein
GIS01_02680	ENOG410667J	hydrolase
GIS01_02690	ENOG4108I62	cina-like protein
GIS01_02700	ENOG4105CVG	Homoserine O-transsuccinylase
GIS01_02710	ENOG4108YXU	transcriptional regulator AsnC family
GIS01_02715	ENOG4105E0M	Sulfatase
GIS01_02750	ENOG4105EMU	Dehydrogenase
GIS01_02755	ENOG4105DZW	Dipeptidase
GIS01_02765	ENOG4108I6A	alcohol dehydrogenase
GIS01_02770	ENOG4108Z5K	methylglyoxal synthase
GIS01_02780	ENOG4108UQY	Iron-storage protein
GIS01_02795	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
GIS01_02800	ENOG410904N	short-chain dehydrogenase reductase
GIS01_02805	ENOG4107R88	Chemotaxis protein (CheV)
GIS01_02820	ENOG4107GZ4	SanA protein
GIS01_02825	ENOG4107MM9	BNR Asp-box repeat-containing protein
GIS01_02835	ENOG4105HMV	Fimbrial protein
GIS01_02845	ENOG4106PG1	outer membrane usher protein
GIS01_02850	ENOG4108FZ9	Chaperone
GIS01_02855	ENOG4105NEV	Fimbrial
GIS01_02870	ENOG4105CEY	Amp-dependent synthetase and ligase
GIS01_02875	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
GIS01_02880	ENOG4108IPT	Naphthoate synthase
GIS01_02885	ENOG4107J5P	Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity)
GIS01_02890	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
GIS01_02895	ENOG4105E4F	Isochorismate synthase
GIS01_02900	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
GIS01_02925	ENOG4105C1J	atp-dependent rna helicase
GIS01_02930	ENOG4105D9N	nucleoside
GIS01_02935	ENOG4107K5X	Membrane-bound metal-dependent hydrolase
GIS01_02940	ENOG4108UPT	UPF0178 protein
GIS01_02960	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
GIS01_02970	ENOG4105E61	Mannitol repressor protein
GIS01_02975	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
GIS01_02980	ENOG4105CTS	PTS system mannitol-specific
GIS01_02985	ENOG4105D1S	lipid A biosynthesis
GIS01_02990	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
GIS01_02995	ENOG4105DFG	type I secretion outer membrane protein
GIS01_03000	ENOG41087AY	ADP-Ribose pyrophosphatase
GIS01_03005	ENOG4108SX3	cytoplasmic protein
GIS01_03010	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
GIS01_03015	ENOG4105IPS	esterase
GIS01_03020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GIS01_03025	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GIS01_03030	ENOG4105DUX	Transporter
GIS01_03050	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
GIS01_03055	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
GIS01_03060	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
GIS01_03065	ENOG4105C5Q	Transcriptional regulator
GIS01_03070	ENOG4105N2G	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GIS01_03090	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
GIS01_03095	ENOG41087YS	Phage shock protein A
GIS01_03110	ENOG41082IR	Excinuclease ABC C subunit domain protein
GIS01_03125	ENOG4108RG0	uracil-dna glycosylase
GIS01_03130	ENOG4105DFI	Membrane
GIS01_03135	ENOG4105ETT	transcriptional Regulator, LysR family
GIS01_03140	ENOG4105FAV	ABC, transporter
GIS01_03145	ENOG4105FDK	ABC transporter
GIS01_03150	ENOG4105NXV	High-affinity zinc uptake system protein
GIS01_03170	ENOG4105DR5	peptidase
GIS01_03180	ENOG4105R2J	Conserved Protein
GIS01_03200	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
GIS01_03205	ENOG4105CEN	a g-specific adenine glycosylase
GIS01_03210	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
GIS01_03220	ENOG4105H4F	exported protein
GIS01_03230	ENOG4105UYK	outer membrane protein a
GIS01_03235	ENOG4106TD9	Diguanylate cyclase
GIS01_03240	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
GIS01_03260	ENOG4105C2N	RNA methyltransferase TrmH family group 3
GIS01_03270	ENOG4107YB6	acetyltransferase, (GNAT) family
GIS01_03275	ENOG4105C1J	atp-dependent rna helicase
GIS01_03280	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
GIS01_03285	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
GIS01_03290	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
GIS01_03305	ENOG4105MYN	Zinc uptake regulation protein
GIS01_03370	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
GIS01_03375	ENOG4105VNT	transposase (IS4 family) protein
GIS01_03380	ENOG4108IQE	Amp-dependent synthetase and ligase
GIS01_03390	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
GIS01_03405	ENOG4105EV2	VWA domain protein interacting with AAA ATPase
GIS01_03410	ENOG4105BZU	Histidine kinase
GIS01_03415	ENOG4105CBZ	Short-chain dehydrogenase reductase Sdr
GIS01_03420	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
GIS01_03425	ENOG4108MJ3	acetyltransferase
GIS01_03430	ENOG4105EV4	Multidrug resistance protein mdtH
GIS01_03445	ENOG4108Z9I	-acetyltransferase
GIS01_03450	ENOG4105D9U	N-acetyltransferase
GIS01_03460	ENOG4105D9R	oxidoreductase
GIS01_03470	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
GIS01_03475	ENOG4105CSA	Coproporphyrinogen iii oxidase
GIS01_03480	ENOG4105VCN	Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system
GIS01_03490	ENOG4105DC1	bifunctional purine biosynthesis protein purh
GIS01_03495	ENOG4105C12	Phosphoribosylglycinamide synthetase
GIS01_03515	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GIS01_03520	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
GIS01_03525	ENOG4105KTH	gatB Yqey
GIS01_03530	ENOG4105VCC	30S ribosomal protein S21
GIS01_03535	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GIS01_03540	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
GIS01_03545	ENOG4108IJ0	Aspartate ammonia-lyase
GIS01_03550	ENOG4105FS0	cytoplasmic membrane protein
GIS01_03560	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
GIS01_03565	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
GIS01_03575	ENOG4105BZU	Histidine kinase
GIS01_03615	ENOG4108IAB	Phoh family
GIS01_03620	ENOG4107T0D	ABC, transporter
GIS01_03625	ENOG4106SMU	thiamine transporter membrane protein
GIS01_03630	ENOG4105DP9	ABC transporter
GIS01_03645	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GIS01_03650	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
GIS01_03655	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
GIS01_03660	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
GIS01_03685	ENOG4105C7K	acetolactate synthase
GIS01_03690	ENOG4108ZP8	Acetolactate synthase small subunit
GIS01_03705	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
GIS01_03710	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
GIS01_03720	ENOG4107KET	secretion protein, HlyD family
GIS01_03750	ENOG4105I93	response regulator
GIS01_03755	ENOG4105DUX	Transporter
GIS01_03760	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
GIS01_03765	ENOG41083P1	competence protein ComEA helix-hairpin-helix repeat protein
GIS01_03770	ENOG4105C6K	Malic enzyme
GIS01_03775	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
GIS01_03780	ENOG4105PQ6	UPF0208 membrane protein
GIS01_03785	ENOG4105XWI	UPF0304 protein
GIS01_03790	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GIS01_03795	ENOG4105RH4	Glycine cleavage system transcriptional repressor
GIS01_03800	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GIS01_03805	ENOG4107EG0	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
GIS01_03810	ENOG4107QWK	SAICAR synthetase
GIS01_03820	ENOG4105EXG	Transcriptional regulator
GIS01_03845	ENOG4105BZU	Histidine kinase
GIS01_03850	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
GIS01_03860	ENOG4105BZU	Histidine kinase
GIS01_03865	ENOG4105BZU	Histidine kinase
GIS01_03870	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_03875	ENOG4105MDZ	Transcriptional activator rfaH
GIS01_03880	ENOG4105D01	(LipO)protein
GIS01_03885	ENOG4108UMI	ABC transporter, permease
GIS01_03890	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_03905	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
GIS01_03910	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
GIS01_03915	ENOG4105K8N	protein family UPF0079, ATPase
GIS01_03920	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
GIS01_03925	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
GIS01_03930	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
GIS01_03935	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
GIS01_03940	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
GIS01_03945	ENOG4107QJR	hflk protein
GIS01_03950	ENOG4105EPW	hflc protein
GIS01_03960	ENOG4105EAH	synthase
GIS01_03965	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
GIS01_03970	ENOG4105K46	50S ribosomal protein l27
GIS01_03975	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GIS01_03980	ENOG4105DWD	nucleoside recognition domain protein
GIS01_03990	ENOG4105DEN	Luciferase family
GIS01_04010	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
GIS01_04015	ENOG4105NWN	ApaG protein
GIS01_04020	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
GIS01_04025	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
GIS01_04030	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
GIS01_04035	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
GIS01_04040	ENOG4105EHM	Aminoglycoside phosphotransferase
GIS01_04045	ENOG4108S0S	Nucleotidyl transferase
GIS01_04050	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
GIS01_04055	ENOG4105CIN	aminoacyl-histidine dipeptidase
GIS01_04065	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
GIS01_04070	ENOG4105V1F	Fermentation respiration switch protein
GIS01_04085	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
GIS01_04100	ENOG4105VYA	Uncharacterized conserved protein (DUF2132)
GIS01_04105	ENOG4105DJ4	phosphatidylserine decarboxylase
GIS01_04115	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
GIS01_04145	ENOG4105VEQ	Cold shock protein
GIS01_04155	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_04160	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
GIS01_04165	ENOG4105C7N	Xanthine uracil vitamin C permease
GIS01_04175	ENOG4105C5H	ABC transporter
GIS01_04190	ENOG4105E4C	Lytic transglycosylase catalytic
GIS01_04200	ENOG4105G4C	Periplasmic ligand-binding sensor protein
GIS01_04210	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
GIS01_04220	ENOG4108JQ7	(ABC) transporter
GIS01_04235	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
GIS01_04240	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
GIS01_04245	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
GIS01_04265	ENOG4109015	Biopolymer transport protein exbD tolR
GIS01_04280	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
GIS01_04285	ENOG4105D07	Signal peptide peptidase, SppA
GIS01_04290	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
GIS01_04295	ENOG41069NU	Nitroreductase
GIS01_04300	ENOG4108UW5	maltose o-acetyltransferase
GIS01_04310	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
GIS01_04315	ENOG4105CIS	alcohol dehydrogenase
GIS01_04320	ENOG4105HEI	LysR family (Transcriptional regulator
GIS01_04325	ENOG4105CI1	PTS System
GIS01_04330	ENOG4108IA2	Sodium pantothenate symporter
GIS01_04340	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
GIS01_04345	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
GIS01_04350	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
GIS01_04355	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GIS01_04365	ENOG4105BZU	Histidine kinase
GIS01_04375	ENOG4109039	Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)
GIS01_04380	ENOG4108EM1	reductase
GIS01_04385	ENOG4105CUW	cytochrome C-TYPE protein
GIS01_04390	ENOG4106WF9	DNA-binding transcriptional regulator TorR
GIS01_04400	ENOG4108SV3	Tmao reductase system periplasmic protein tort
GIS01_04405	ENOG4105BZU	Histidine kinase
GIS01_04415	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
GIS01_04420	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
GIS01_04425	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
GIS01_04440	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
GIS01_04445	ENOG4107YIM	Involved in the transcription termination process (By similarity)
GIS01_04450	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
GIS01_04455	ENOG4108ZAI	phosphatidylglycerophosphatase a
GIS01_04460	ENOG4108JQ6	ABC transporter
GIS01_04470	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GIS01_04480	ENOG41069P5	Protein slyX homolog
GIS01_04490	ENOG4108V1T	peptidylprolyl cis-trans isomerase
GIS01_04495	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_04515	ENOG4105CGH	5'-nucleotidase
GIS01_04520	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
GIS01_04525	ENOG4105CTB	Polyprenyl synthetase
GIS01_04530	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
GIS01_04535	ENOG4105E14	MotA TolQ exbB proton channel
GIS01_04540	ENOG4107XSU	flagellar motor protein motb
GIS01_04545	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
GIS01_04555	ENOG4105HBR	Rna-binding protein
GIS01_04560	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
GIS01_04565	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
GIS01_04570	ENOG4105EEI	dihydropteroate synthase
GIS01_04575	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
GIS01_04580	ENOG4105CP7	Triose-phosphate isomerase
GIS01_04600	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
GIS01_04605	ENOG4105CHV	Transcription elongation factor NusA
GIS01_04610	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
GIS01_04615	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
GIS01_04620	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
GIS01_04625	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
GIS01_04630	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
GIS01_04635	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
GIS01_04640	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
GIS01_04645	ENOG4105BZU	Histidine kinase
GIS01_04650	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_04655	ENOG4108V3W	Chemotaxis protein, CheW
GIS01_04665	ENOG4105CBS	Chea signal transduction histidine kinase
GIS01_04675	ENOG4108VYJ	response regulator receiver protein
GIS01_04680	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_04685	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GIS01_04695	ENOG4105N14	lysine exporter protein LysE YggA
GIS01_04700	ENOG4105CFP	Peptidase U32
GIS01_04705	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
GIS01_04745	ENOG4105CTD	carboxy-peptidase
GIS01_04770	ENOG4105E1F	short-chain dehydrogenase reductase
GIS01_04780	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_04825	ENOG4105DVA	methyltransferase
GIS01_04835	ENOG4108W0P	ABC transporter
GIS01_04840	ENOG4105EHG	Permease protein
GIS01_04865	ENOG4105E2Y	ABC, transporter
GIS01_04885	ENOG4107ZSV	Receptor
GIS01_04910	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
GIS01_04915	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GIS01_04935	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GIS01_04950	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
GIS01_04975	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GIS01_04980	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
GIS01_04990	ENOG4105W5Q	DNA repair protein (RadC
GIS01_05035	ENOG4108NF7	phage-type endonuclease
GIS01_05065	ENOG4105CQC	Prephenate dehydratase
GIS01_05080	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GIS01_05095	ENOG4107SEY	Conserved Protein
GIS01_05100	ENOG4108XDN	Transcriptional regulator
GIS01_05105	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
GIS01_05115	ENOG4107FW0	short-chain dehydrogenase reductase
GIS01_05130	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
GIS01_05160	ENOG4105CJ2	(LipO)protein
GIS01_05165	ENOG4105D26	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
GIS01_05170	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_05175	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_05180	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_05185	ENOG4108J5C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_05190	ENOG4105DWQ	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_05195	ENOG4105M85	Bola protein
GIS01_05200	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
GIS01_05210	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
GIS01_05215	ENOG4105EYM	Major Facilitator superfamily
GIS01_05220	ENOG4105DRB	nucleoside-specific channel-forming protein
GIS01_05225	ENOG4108VPT	UPF0234 protein
GIS01_05230	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
GIS01_05235	ENOG4107S0N	DJ-1 family
GIS01_05245	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
GIS01_05250	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_05255	ENOG4105ETT	transcriptional Regulator, LysR family
GIS01_05265	ENOG4105M08	Membrane
GIS01_05270	ENOG4105EZ6	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity)
GIS01_05280	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
GIS01_05285	ENOG4105CIQ	May have a role in processing of nucleic acids. It is probably not an exonuclease
GIS01_05290	ENOG4105EWT	decarboxylase family
GIS01_05295	ENOG4105BZU	Histidine kinase
GIS01_05305	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
GIS01_05310	ENOG4108T6E	Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)
GIS01_05315	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
GIS01_05340	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GIS01_05365	ENOG4108ZUE	Phage regulatory protein rha
GIS01_05420	ENOG4105EXF	Zn-ribbon-containing, possibly nucleic-acid-binding protein
GIS01_05445	ENOG4105WP7	tRNA pseudouridine synthase C
GIS01_05450	ENOG4105DR9	pseudouridine synthase
GIS01_05455	ENOG4105QDK	Flavodoxin
GIS01_05460	ENOG4108KDD	Involved in the transport of maltose and maltodextrins (By similarity)
GIS01_05465	ENOG4107W52	maltose operon periplasmic protein
GIS01_05470	ENOG4105CI1	PTS System
GIS01_05475	ENOG4108T8E	UPF0325 protein
GIS01_05480	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
GIS01_05485	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
GIS01_05490	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
GIS01_05495	ENOG4105CE9	30S ribosomal protein S2
GIS01_05500	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
GIS01_05505	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
GIS01_05510	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
GIS01_05515	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
GIS01_05520	ENOG4105KNE	Phosphatidate cytidylyltransferase
GIS01_05525	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
GIS01_05530	ENOG4105DZP	Membrane-associated zinc metalloprotease
GIS01_05540	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
GIS01_05545	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GIS01_05550	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
GIS01_05555	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GIS01_05560	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GIS01_05565	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GIS01_05570	ENOG4105C0B	DNA polymerase III (alpha subunit)
GIS01_05575	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
GIS01_05585	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
GIS01_05590	ENOG4105BZG	amino acid carrier protein
GIS01_05595	ENOG4105F8C	transglutaminase domain-containing protein
GIS01_05605	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
GIS01_05610	ENOG41066YJ	Beta-lactamase
GIS01_05620	ENOG4105G2Y	Transcriptional regulator
GIS01_05625	ENOG4105DUX	Transporter
GIS01_05630	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
GIS01_05640	ENOG4105D7Z	glutathione synthase
GIS01_05645	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
GIS01_05655	ENOG4105GPY	SprT protein
GIS01_05660	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
GIS01_05665	ENOG4105CV1	Transketolase (EC 2.2.1.1)
GIS01_05680	ENOG4106KR7	LysR family Transcriptional regulator
GIS01_05685	ENOG4105TMR	Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity)
GIS01_05710	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
GIS01_05715	ENOG4105DR5	peptidase
GIS01_05720	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
GIS01_05735	ENOG4105C7K	acetolactate synthase
GIS01_05745	ENOG4105EQ2	LysR family Transcriptional regulator
GIS01_05750	ENOG4105C44	Serine transporter
GIS01_05765	ENOG4105EXG	Transcriptional regulator
GIS01_05770	ENOG4105DVH	amino acid
GIS01_05775	ENOG4108M3R	transcriptional activator CadC
GIS01_05780	ENOG4105D5Q	Arginine ornithine antiporter
GIS01_05785	ENOG4105CXN	decarboxylase
GIS01_05790	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
GIS01_05800	ENOG4105C9K	Endothelin-converting enzyme 1
GIS01_05805	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
GIS01_05810	ENOG4105BZU	Histidine kinase
GIS01_05845	ENOG4107T9C	Alpha amylase catalytic region
GIS01_05875	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
GIS01_05880	ENOG4105EAQ	(twin-arginine translocation) pathway signal
GIS01_05890	ENOG4105EN6	Membrane
GIS01_05895	ENOG4105EXN	Sulfate transport protein CysZ
GIS01_05900	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
GIS01_05905	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
GIS01_05910	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
GIS01_05920	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
GIS01_05925	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
GIS01_05955	ENOG4105J12	Multidrug resistance protein mdtN
GIS01_05960	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
GIS01_05970	ENOG4107R1I	NAD-dependent malic enzyme
GIS01_05975	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
GIS01_05980	ENOG4106YYS	transcriptional regulatory protein
GIS01_05985	ENOG4108IPJ	Membrane
GIS01_05995	ENOG4105BZU	Histidine kinase
GIS01_06000	ENOG4108ZI4	Glyoxalase Bleomycin resistance protein (Dioxygenase
GIS01_06005	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GIS01_06010	ENOG4105BZU	Histidine kinase
GIS01_06020	ENOG4105ERG	peptidase m48, ste24p
GIS01_06035	ENOG4106N3A	copper homeostasis protein cutc
GIS01_06040	ENOG4108V1T	peptidylprolyl cis-trans isomerase
GIS01_06055	ENOG4105PTV	Nudix Hydrolase
GIS01_06080	ENOG4105BZG	amino acid carrier protein
GIS01_06085	ENOG4108KMH	lipoate-protein ligase a
GIS01_06090	ENOG4105C2W	permease
GIS01_06095	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
GIS01_06100	ENOG4105RKX	Protein of unknown function (DUF2498)
GIS01_06105	ENOG4105UQX	Mate efflux family protein
GIS01_06110	ENOG4105ECQ	AraC Family Transcriptional Regulator
GIS01_06115	ENOG4107R1I	NAD-dependent malic enzyme
GIS01_06120	ENOG4105UYK	outer membrane protein a
GIS01_06130	ENOG4105UYK	outer membrane protein a
GIS01_06145	ENOG4107R7I	amino acid
GIS01_06150	ENOG4105D78	K07001 NTE family protein
GIS01_06155	ENOG4105BZU	Histidine kinase
GIS01_06160	ENOG4105J12	Multidrug resistance protein mdtN
GIS01_06170	ENOG4105CCT	upf0313 protein
GIS01_06220	ENOG4105EP9	oxidoreductase
GIS01_06225	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
GIS01_06230	ENOG4105EM2	membrane
GIS01_06235	ENOG4108MN8	Membrane
GIS01_06280	ENOG4108VAU	general secretion pathway protein G
GIS01_06285	ENOG4105D7Q	type ii secretion system
GIS01_06290	ENOG4107QHF	type ii secretion system protein e
GIS01_06295	ENOG4105GVR	general secretion pathway protein D
GIS01_06315	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_06335	ENOG4105C6T	cysteine synthase
GIS01_06340	ENOG4105KZ7	phosphocarrier protein hpr
GIS01_06350	ENOG4105C5Y	PTS System
GIS01_06355	ENOG4105BZU	Histidine kinase
GIS01_06360	ENOG4105C9K	Endothelin-converting enzyme 1
GIS01_06370	ENOG4105EGS	Mechanosensitive ion channel
GIS01_06375	ENOG4105CA9	Pyruvate kinase
GIS01_06385	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
GIS01_06390	ENOG4105EYH	Exonuclease
GIS01_06395	ENOG4107RH8	nuclease SbcCD subunit D
GIS01_06405	ENOG4105DH7	May be involved in recombination (By similarity)
GIS01_06410	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
GIS01_06415	ENOG4108V1T	peptidylprolyl cis-trans isomerase
GIS01_06430	ENOG4105CUB	amino acid
GIS01_06440	ENOG4105CUB	amino acid
GIS01_06445	ENOG4108JPW	Aminotransferase
GIS01_06450	ENOG4105C26	Dehydrogenase
GIS01_06455	ENOG4107VRI	Transcriptional regulator
GIS01_06460	ENOG4105CJP	fad dependent oxidoreductase
GIS01_06480	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
GIS01_06490	ENOG4105CPW	cytochrome b561
GIS01_06495	ENOG4108R96	Methyltransferase, YaeB family
GIS01_06515	ENOG4108JJ8	(ABC) transporter
GIS01_06520	ENOG4108JJ9	ABC, transporter
GIS01_06535	ENOG41065U4	response regulator
GIS01_06545	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
GIS01_06575	ENOG4105D6J	arsenicaL-resistance protein
GIS01_06585	ENOG4105D9N	nucleoside
GIS01_06605	ENOG4105S2T	inner membrane protein YbcI
GIS01_06620	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
GIS01_06625	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
GIS01_06630	ENOG4105DK0	Indole-3-glycerol phosphate synthase
GIS01_06635	ENOG4108I0Q	anthranilate phosphoribosyltransferase
GIS01_06640	ENOG4108EFP	Anthranilate synthase component II
GIS01_06645	ENOG4105CRQ	synthase (Component I)
GIS01_06650	ENOG4105DB7	PHP domain protein
GIS01_06655	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
GIS01_06665	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
GIS01_06670	ENOG4105FE9	pseudouridine synthase
GIS01_06680	ENOG4105C29	acyl-CoA thioesterase
GIS01_06685	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
GIS01_06690	ENOG4106FVC	RNA methyltransferase
GIS01_06705	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
GIS01_06710	ENOG4105D98	threonine synthase
GIS01_06730	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
GIS01_06735	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_06750	ENOG4105VYW	UPF0251 protein
GIS01_06765	ENOG4108IG5	Transcriptional regulator
GIS01_06770	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
GIS01_06775	ENOG4105BZS	acriflavin resistance protein
GIS01_06780	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
GIS01_06785	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
GIS01_06790	ENOG4108IJ1	Dehydrogenase
GIS01_06795	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
GIS01_06800	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
GIS01_06810	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
GIS01_06820	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
GIS01_06825	ENOG4108Z7G	MaoC domain protein dehydratase
GIS01_06855	ENOG4107QRS	glycosyltransferase group 2 family protein
GIS01_06860	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
GIS01_06865	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
GIS01_06875	ENOG4105C5E	polysaccharide biosynthesis protein
GIS01_06885	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
GIS01_06900	ENOG4105D3Q	Sugar transferase
GIS01_06920	ENOG4108QY5	Ferric enterobactin transport protein
GIS01_06930	ENOG4105D75	Capsular exopolysaccharide family
GIS01_06950	ENOG4105E3R	(LipO)protein
GIS01_06960	ENOG4108YX2	DNA-binding protein
GIS01_06965	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
GIS01_06970	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GIS01_06975	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
GIS01_06980	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
GIS01_06985	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
GIS01_06990	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
GIS01_06995	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GIS01_07000	ENOG4105CFG	Acts as a chaperone (By similarity)
GIS01_07005	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
GIS01_07015	ENOG4105D7K	pfkb domain protein
GIS01_07025	ENOG4108HKT	sucrose-6-phosphate hydrolase
GIS01_07030	ENOG4105WBN	Transcriptional regulator (LacI family
GIS01_07065	ENOG4105KFG	YeeE YedE family protein
GIS01_07080	ENOG4105EFX	secretion protein, HlyD family
GIS01_07085	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GIS01_07090	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GIS01_07095	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
GIS01_07100	ENOG4105BZU	Histidine kinase
GIS01_07105	ENOG4107RMF	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity)
GIS01_07115	ENOG4105K4T	epimerase
GIS01_07120	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
GIS01_07125	ENOG4105C0A	alcohol dehydrogenase
GIS01_07130	ENOG4107SXA	Phosphorylase
GIS01_07135	ENOG4105D3G	Pseudouridine synthase
GIS01_07140	ENOG4105DU0	nucleoside hydrolase
GIS01_07160	ENOG4105RX8	Protein of unknown function (DUF1523)
GIS01_07170	ENOG410829K	Lysine exporter protein (Lyse ygga)
GIS01_07185	ENOG4105C3N	Participates in control of cell volume in low-osmolarity conditions (By similarity)
GIS01_07200	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
GIS01_07205	ENOG4105KUZ	arsenate reductase
GIS01_07215	ENOG4105CEE	C4-dicarboxylate transporter
GIS01_07220	ENOG4105CH2	amidohydrolase
GIS01_07230	ENOG4105DS2	Anaerobic c4-dicarboxylate transporter
GIS01_07240	ENOG4105C5S	asparaginyl-tRNA synthetase
GIS01_07255	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
GIS01_07260	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
GIS01_07265	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
GIS01_07270	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
GIS01_07275	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
GIS01_07280	ENOG4105D0M	Protease HtpX homolog
GIS01_07285	ENOG4107SDU	Methyl-accepting chemotaxis
GIS01_07290	ENOG4105QVC	MOSC domain-containing protein
GIS01_07290	ENOG4105QVC	MOSC domain-containing protein
GIS01_07305	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GIS01_07315	ENOG4108535	NAD dependent epimerase/dehydratase family
GIS01_07320	ENOG4105NAU	thioesterase Superfamily protein
GIS01_07335	ENOG41090BQ	Glutaredoxin
GIS01_07340	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
GIS01_07345	ENOG4105CFI	type iii restriction protein res subunit
GIS01_07350	ENOG4105EFX	secretion protein, HlyD family
GIS01_07355	ENOG4105KK7	inner membrane protein YiaW
GIS01_07365	ENOG4108NEV	two component transcriptional regulator, LytTR family
GIS01_07370	ENOG4108HRK	Histidine kinase
GIS01_07375	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_07380	ENOG4105DIJ	Phosphoethanolamine transferase
GIS01_07385	ENOG4105E2R	ROK family
GIS01_07390	ENOG4105CE4	GlcNAc 6-P deacetylase
GIS01_07395	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
GIS01_07400	ENOG4105CI1	PTS System
GIS01_07405	ENOG4105E2D	ec 3.2.1.52
GIS01_07410	ENOG4105CX6	glutaminyL-tRNA synthetase
GIS01_07415	ENOG41090R7	Ferric uptake
GIS01_07425	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
GIS01_07430	ENOG4105NNH	LexA regulated protein
GIS01_07440	ENOG4105EV9	Alpha Beta Hydrolase
GIS01_07445	ENOG4107CDU	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)
GIS01_07450	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
GIS01_07465	ENOG4105CVE	Lytic murein transglycosylase
GIS01_07470	ENOG4108T9J	Cdp-alcohol phosphatidyltransferase
GIS01_07475	ENOG4108VGW	abc transporter atp-binding protein
GIS01_07485	ENOG4105VNH	ABC transporter solute-binding protein
GIS01_07495	ENOG4107ZN8	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
GIS01_07505	ENOG4105KQ5	peptidylprolyl cis-trans isomerase
GIS01_07515	ENOG4105CFU	surface antigen
GIS01_07520	ENOG4105MA0	exported protein
GIS01_07540	ENOG4108WPH	sigma 54 modulation protein ribosomal protein S30EA
GIS01_07545	ENOG4105BZU	Histidine kinase
GIS01_07550	ENOG4107SC1	transglycosylase
GIS01_07555	ENOG41060NJ	transcriptional regulator
GIS01_07560	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
GIS01_07565	ENOG4105D05	Receptor
GIS01_07570	ENOG4105E4F	Isochorismate synthase
GIS01_07575	ENOG4108IQC	2,3-dihydroxybenzoate-AMP ligase
GIS01_07580	ENOG4105WQI	isochorismatase
GIS01_07585	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
GIS01_07590	ENOG4105C0W	non-ribosomal peptide synthetase
GIS01_07600	ENOG4107RUY	(E1 component), alpha subunit
GIS01_07605	ENOG4105CPP	Dehydrogenase, E1 component
GIS01_07610	ENOG4107QSN	dihydrolipoamide acetyltransferase
GIS01_07615	ENOG4105VEQ	Cold shock protein
GIS01_07640	ENOG4105E43	Extracellular solute-binding protein, family 5
GIS01_07645	ENOG4105N2W	Transcriptional regulator
GIS01_07650	ENOG4105C6N	Formate acetyltransferase
GIS01_07655	ENOG4105F1A	Pyruvate formate-lyase
GIS01_07660	ENOG4107T9Z	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
GIS01_07670	ENOG4105DHT	Metal Dependent Phosphohydrolase
GIS01_07675	ENOG4105I08	Pseudouridine synthase
GIS01_07685	ENOG4107QSI	ABC, transporter
GIS01_07690	ENOG4108RE9	Phosphodiesterase
GIS01_07705	ENOG4107ESN	Flagella basal body P-ring formation protein flgA
GIS01_07710	ENOG4107R88	Chemotaxis protein (CheV)
GIS01_07715	ENOG4105BZU	Histidine kinase
GIS01_07720	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
GIS01_07725	ENOG4108ZC9	flagellar basal-body rod protein flgc
GIS01_07730	ENOG4105W00	Flagellar hook capping protein
GIS01_07735	ENOG4105BZE	flagellar hook protein, FlgE
GIS01_07740	ENOG4108KPB	Flagellar basal-body rod protein FlgF
GIS01_07745	ENOG4105CGA	flagellar basal-body rod protein FlgG
GIS01_07750	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
GIS01_07755	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
GIS01_07760	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
GIS01_07770	ENOG4105DTJ	flagellar hook-associated protein
GIS01_07775	ENOG4105CJW	magnesium transporter
GIS01_07780	ENOG4105C9X	ppx gppa phosphatase
GIS01_07785	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
GIS01_07790	ENOG4105RH4	Glycine cleavage system transcriptional repressor
GIS01_07800	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_07805	ENOG4105BZU	Histidine kinase
GIS01_07810	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_07815	ENOG4107QNR	UPF0135 protein
GIS01_07820	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
GIS01_07825	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
GIS01_07830	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
GIS01_07845	ENOG4108I9X	Isocitrate lyase
GIS01_07850	ENOG4107QP3	malate synthase g
GIS01_07860	ENOG4108Z6B	deaminase
GIS01_07865	ENOG4105C8U	phosphate abc transporter
GIS01_07870	ENOG4105E2Z	phosphate ABC transporter (Permease
GIS01_07875	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
GIS01_07885	ENOG4105C37	(CBS) domain
GIS01_07895	ENOG4105C3R	Methionine synthase
GIS01_07900	ENOG4105D5Q	Arginine ornithine antiporter
GIS01_07915	ENOG4105CDA	abc transporter atp-binding protein
GIS01_07920	ENOG4105E5Q	amino acid AbC transporter
GIS01_07925	ENOG4106PMH	Extracellular solute-binding protein family 3
GIS01_07930	ENOG4105BZU	Histidine kinase
GIS01_07935	ENOG4105CXY	transporter
GIS01_07940	ENOG4105BZU	Histidine kinase
GIS01_07945	ENOG4108KX4	response regulator
GIS01_07950	ENOG4105NXH	GreA GreB family elongation factor
GIS01_07970	ENOG4105G6Z	alkaline phosphatase
GIS01_07975	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
GIS01_07980	ENOG4105DGU	Histone deacetylase
GIS01_07990	ENOG4105DVT	helicase
GIS01_08005	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
GIS01_08015	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GIS01_08020	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GIS01_08055	ENOG4105K59	histidine triad (HIT) protein
GIS01_08060	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_08070	ENOG4105CD3	dihydroorotase
GIS01_08085	ENOG4105CK2	sodium dicarboxylate symporter
GIS01_08090	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_08100	ENOG4105CKW	Inner membrane protein yedI
GIS01_08105	ENOG4105DPN	Oligoendopeptidase f
GIS01_08110	ENOG4105C2W	permease
GIS01_08120	ENOG4105CEP	NADH dehydrogenase
GIS01_08130	ENOG4105F1A	Pyruvate formate-lyase
GIS01_08135	ENOG4105BZU	Histidine kinase
GIS01_08140	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
GIS01_08150	ENOG4105DN3	alpha-2-macroglobulin domain protein
GIS01_08155	ENOG4108JQB	penicillin-binding protein 1C
GIS01_08185	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GIS01_08255	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
GIS01_08265	ENOG4105EN6	Membrane
GIS01_08290	ENOG41063QE	flagellar protein FlaG
GIS01_08300	ENOG4105MQ3	flagellar protein FliS
GIS01_08320	ENOG4105F0R	Cytidylyltransferase
GIS01_08325	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
GIS01_08330	ENOG4108S0S	Nucleotidyl transferase
GIS01_08335	ENOG4108Z7G	MaoC domain protein dehydratase
GIS01_08340	ENOG4107WZ3	Transferase
GIS01_08345	ENOG4105D2T	synthase
GIS01_08350	ENOG4107SE4	UDP-N-acetylglucosamine 2-epimerase
GIS01_08355	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
GIS01_08380	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
GIS01_08390	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_08405	ENOG4105CYM	Glutathione S-transferase
GIS01_08410	ENOG4105E5M	Multidrug resistance protein D
GIS01_08415	ENOG4105EJC	lysr family transcriptional regulator
GIS01_08420	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GIS01_08425	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
GIS01_08435	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
GIS01_08445	ENOG4105D0A	hydroxylase
GIS01_08450	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
GIS01_08460	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
GIS01_08465	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
GIS01_08470	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIS01_08475	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
GIS01_08495	ENOG4105C85	amino acid
GIS01_08505	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
GIS01_08510	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
GIS01_08525	ENOG4105D01	(LipO)protein
GIS01_08530	ENOG4105E68	Sulfatase
GIS01_08535	ENOG4105PAN	UPF0352 protein
GIS01_08540	ENOG4106V8H	Nucleoid-associated protein
GIS01_08545	ENOG4107FKK	extracellular solute-binding protein family 1
GIS01_08550	ENOG4105D56	permease protein
GIS01_08555	ENOG4105EG2	ABC transporter, permease
GIS01_08560	ENOG4108IJ9	(ABC) transporter
GIS01_08565	ENOG4105CSR	polyphosphate kinase 2
GIS01_08590	ENOG4105ERG	peptidase m48, ste24p
GIS01_08600	ENOG4105K89	arsenate reductase
GIS01_08615	ENOG4106PMH	Extracellular solute-binding protein family 3
GIS01_08620	ENOG4105DYB	Isoaspartyl dipeptidase
GIS01_08625	ENOG4105DWU	Membrane
GIS01_08630	ENOG4108JEH	abc transporter atp-binding protein
GIS01_08635	ENOG4106PMH	Extracellular solute-binding protein family 3
GIS01_08640	ENOG4105DSP	amino acid AbC transporter
GIS01_08645	ENOG4106YG3	ABC transporter
GIS01_08650	ENOG4108W1A	pseudouridine synthase
GIS01_08660	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
GIS01_08665	ENOG4105F1J	Homogentisate 1,2-dioxygenase
GIS01_08675	ENOG4108RXX	maleylacetoacetate isomerase
GIS01_08685	ENOG4105CAQ	asparagine synthetase
GIS01_08695	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
GIS01_08700	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
GIS01_08705	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
GIS01_08715	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
GIS01_08720	ENOG4105EE5	Membrane protein terC
GIS01_08730	ENOG4105CQB	FAD linked oxidase domain protein
GIS01_08740	ENOG4105KA0	thioesterase Superfamily protein
GIS01_08750	ENOG4105D3Y	Na H antiporter
GIS01_08755	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
GIS01_08760	ENOG4105EYK	Phosphatidylglycerophosphatase B
GIS01_08765	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
GIS01_08770	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
GIS01_08780	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
GIS01_08785	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
GIS01_08790	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
GIS01_08795	ENOG4108S3P	Sporulation domain protein
GIS01_08800	ENOG4105K8R	UPF0145 protein
GIS01_08810	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GIS01_08815	ENOG410810Y	Sulfite reductase
GIS01_08820	ENOG4107SHJ	sulfite reductase subunit b
GIS01_08825	ENOG4105D5B	Sulfite reductase, subunit A
GIS01_08830	ENOG4108NRW	Phospholipase, patatin family
GIS01_08835	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
GIS01_08840	ENOG4107T7U	Sulfatase
GIS01_08850	ENOG4105CFH	Aspartokinase
GIS01_08855	ENOG4107QZM	n-acetylglutamate synthase
GIS01_08860	ENOG4107QXP	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
GIS01_08930	ENOG4105F2Z	3-oxoadipate enol-lactonase
GIS01_08960	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
GIS01_08975	ENOG4105C2C	drug resistance transporter, Bcr CflA
GIS01_09035	ENOG4105CHH	sulfate transporter
GIS01_09085	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
GIS01_09090	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
GIS01_09095	ENOG4108JQ2	peptide transport system atp-binding protein
GIS01_09100	ENOG4108JQ3	Peptide ABC transporter ATP-binding protein
GIS01_09105	ENOG4108EU3	peptide transport system, permease
GIS01_09110	ENOG4108I5W	peptide transport system, permease protein
GIS01_09115	ENOG4108J59	Extracellular solute-binding protein, family 5
GIS01_09120	ENOG4105E51	psp operon transcriptional activator
GIS01_09125	ENOG41087YS	Phage shock protein A
GIS01_09130	ENOG4105YYT	phage shock protein B
GIS01_09140	ENOG4105CM6	amino acid regulated cytosolic protein
GIS01_09145	ENOG4106K28	UPF0283 membrane protein
GIS01_09150	ENOG4108M0I	Transcriptional regulator
GIS01_09155	ENOG4107TYH	extracellular solute-binding protein family 1
GIS01_09160	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_09165	ENOG4105D81	ABC transporter, permease
GIS01_09170	ENOG4105NRK	Binding-protein-dependent transport systems, inner membrane component
GIS01_09175	ENOG4105C26	Dehydrogenase
GIS01_09180	ENOG4105MIR	Phenylalanine 4-monooxygenase
GIS01_09185	ENOG41090A4	Pterin carbinolamine dehydratase
GIS01_09205	ENOG4108KHX	Diguanylate cyclase
GIS01_09210	ENOG41090EK	ompa motb domain protein
GIS01_09215	ENOG4105EE5	Membrane protein terC
GIS01_09225	ENOG4105MH2	YfcL protein
GIS01_09245	ENOG4108RYK	Nad-dependent epimerase dehydratase
GIS01_09250	ENOG4105CR8	Transcriptional regulator
GIS01_09255	ENOG41064T2	transcriptional regulator, lysR family
GIS01_09265	ENOG4105EUB	pirin domain protein
GIS01_09270	ENOG4105CHJ	isochorismatase hydrolase
GIS01_09275	ENOG4105EXG	Transcriptional regulator
GIS01_09280	ENOG4105DZ2	Transcriptional regulator
GIS01_09285	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
GIS01_09295	ENOG4108KB2	LysR family Transcriptional regulator
GIS01_09300	ENOG4105CS2	ec 3.2.1.21
GIS01_09305	ENOG4105DDY	UPF0142 protein ycaO
GIS01_09310	ENOG4105TMB	Formate nitrite transporter
GIS01_09315	ENOG4105C6N	Formate acetyltransferase
GIS01_09325	ENOG4108J59	Extracellular solute-binding protein, family 5
GIS01_09330	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GIS01_09335	ENOG4108JA2	transcriptioN-repair coupling factor
GIS01_09345	ENOG4105D60	lipoprotein releasing system transmembrane protein
GIS01_09350	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
GIS01_09355	ENOG4105D60	lipoprotein releasing system transmembrane protein
GIS01_09360	ENOG4105DK2	UPF0207 protein
GIS01_09370	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
GIS01_09375	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
GIS01_09380	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
GIS01_09385	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
GIS01_09390	ENOG4105K70	DNA-binding protein
GIS01_09395	ENOG4105EIN	peptidylprolyl cis-trans isomerase
GIS01_09400	ENOG4105C5H	ABC transporter
GIS01_09405	ENOG4107QN1	sodium solute
GIS01_09410	ENOG41062QD	Membrane
GIS01_09425	ENOG41060WC	Enoyl-CoA hydratase
GIS01_09430	ENOG4105ED4	portal protein
GIS01_09475	ENOG4105BZG	amino acid carrier protein
GIS01_09490	ENOG4106HK8	GPR1 FUN34 yaaH family protein
GIS01_09510	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
GIS01_09520	ENOG4105E39	Enoyl-CoA hydratase
GIS01_09525	ENOG4107QX3	carboxylase
GIS01_09530	ENOG4105C1G	acyl-Coa dehydrogenase
GIS01_09535	ENOG4105C1G	acyl-Coa dehydrogenase
GIS01_09540	ENOG4105E39	Enoyl-CoA hydratase
GIS01_09545	ENOG4105E39	Enoyl-CoA hydratase
GIS01_09550	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
GIS01_09555	ENOG4105CHR	reductase
GIS01_09560	ENOG4105D5Q	Arginine ornithine antiporter
GIS01_09565	ENOG4105HF0	Membrane
GIS01_09590	ENOG4105F9F	transposase
GIS01_09600	ENOG4105BZU	Histidine kinase
GIS01_09605	ENOG4105BZU	Histidine kinase
GIS01_09620	ENOG4105W5Q	DNA repair protein (RadC
GIS01_09675	ENOG4105ENX	hydrolase
GIS01_09680	ENOG4105EQ2	LysR family Transcriptional regulator
GIS01_09685	ENOG4105BZU	Histidine kinase
GIS01_09715	ENOG4105F8J	Adenylate Guanylate cyclase
GIS01_09720	ENOG4105CG5	Glycosyl transferase (Group 1
GIS01_09730	ENOG4107QZ7	Cellulose synthase catalytic subunit
GIS01_09735	ENOG4108KMV	Glycosyl transferase (Group 1
GIS01_09780	ENOG4107EF8	Glycosyl transferase (Group 1
GIS01_09800	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
GIS01_09805	ENOG4107UU3	sucrose-phosphate synthase (EC 2.4.1.14)
GIS01_09815	ENOG4108ESY	Metal dependent phosphohydrolase
GIS01_09820	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_09825	ENOG4105BZU	Histidine kinase
GIS01_09830	ENOG4105E3S	small subunit
GIS01_09835	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GIS01_09840	ENOG4105CJ5	hydrogenase 2 b cytochrome subunit
GIS01_09845	ENOG4105DPX	Hydrogenase, large subunit
GIS01_09850	ENOG4108USZ	hydrogenase
GIS01_09855	ENOG4108WGS	hydrogenase 2-specific chaperone
GIS01_09865	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GIS01_09870	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
GIS01_09880	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_09885	ENOG4107RSS	Hydrogenase accessory protein HypB
GIS01_09890	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
GIS01_09895	ENOG4105C45	hydrogenase expression formation protein (HypE)
GIS01_09900	ENOG4105CQS	hydrogenase expression formation protein HypD
GIS01_09905	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
GIS01_09915	ENOG4105EM7	Selenocysteine-specific translation elongation factor
GIS01_09920	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
GIS01_09930	ENOG4108MG9	hydrogenase 3 maturation protease
GIS01_09935	ENOG4105I6X	formate hydrogenlyase maturation
GIS01_09940	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
GIS01_09950	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_09955	ENOG4107TDF	Formate hydrogenlyase subunit 4
GIS01_09960	ENOG4108JPZ	Monovalent cation H antiporter subunit D
GIS01_09965	ENOG4108MFN	small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex)
GIS01_09970	ENOG4105DFH	Transport of potassium into the cell (By similarity)
GIS01_09985	ENOG4108RC0	Electron transport protein
GIS01_10005	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GIS01_10010	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
GIS01_10015	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
GIS01_10020	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
GIS01_10030	ENOG4105C0F	tryptophanase EC 4.1.99.1
GIS01_10035	ENOG4107T42	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity)
GIS01_10040	ENOG41067MG	lrgb family
GIS01_10050	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
GIS01_10060	ENOG4105CJB	Exodeoxyribonuclease I
GIS01_10070	ENOG4105DHT	Metal Dependent Phosphohydrolase
GIS01_10080	ENOG4105CQ7	ATP-dependent helicase
GIS01_10090	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
GIS01_10100	ENOG4105CHU	acetyl-coa acetyltransferase
GIS01_10105	ENOG4105D58	Diguanylate phosphodiesterase
GIS01_10110	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
GIS01_10115	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
GIS01_10125	ENOG4105EMN	RNA polymerase sigma factor
GIS01_10155	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
GIS01_10160	ENOG4105CHU	acetyl-coa acetyltransferase
GIS01_10165	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GIS01_10170	ENOG4105ED1	spovr family
GIS01_10175	ENOG4106AKX	UPF0229 protein
GIS01_10180	ENOG4105CYN	Serine protein kinase
GIS01_10185	ENOG4105C9U	ATP-dependent DNA helicase RecQ
GIS01_10190	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
GIS01_10200	ENOG4105C44	Serine transporter
GIS01_10205	ENOG4105P8F	nudix hydrolase
GIS01_10220	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
GIS01_10235	ENOG4105CVJ	phosphoglycerate mutase
GIS01_10240	ENOG4105BZU	Histidine kinase
GIS01_10245	ENOG4108DG9	Smr protein MutS2
GIS01_10250	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
GIS01_10255	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
GIS01_10265	ENOG4105C1J	atp-dependent rna helicase
GIS01_10275	ENOG4105WJG	Glutathione
GIS01_10290	ENOG4105E0U	tyrosine-specific transport protein
GIS01_10295	ENOG4107B7Y	DNA-binding transcriptional regulator FruR
GIS01_10300	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
GIS01_10305	ENOG4105DE4	1-phosphofructokinase
GIS01_10310	ENOG4105DM4	PTS System
GIS01_10315	ENOG4105XZD	Fe-S protein
GIS01_10320	ENOG4105CA3	membrane-bound lytic murein transglycosylase
GIS01_10325	ENOG4105XPH	Ferredoxin
GIS01_10330	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GIS01_10335	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
GIS01_10340	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GIS01_10345	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
GIS01_10350	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
GIS01_10370	ENOG4105C22	threonyL-tRNA synthetase
GIS01_10375	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
GIS01_10385	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
GIS01_10390	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
GIS01_10395	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
GIS01_10400	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GIS01_10405	ENOG4105BZU	Histidine kinase
GIS01_10420	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
GIS01_10430	ENOG4105BZU	Histidine kinase
GIS01_10435	ENOG4105ETE	Transcriptional regulator (LacI family
GIS01_10440	ENOG4108RVA	ribokinase
GIS01_10445	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
GIS01_10450	ENOG4105CNN	ABC, transporter
GIS01_10455	ENOG4105C2J	ABC transporter
GIS01_10460	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
GIS01_10465	ENOG4108K3A	Glutathione S-transferase
GIS01_10475	ENOG4107RUE	extracellular solute-binding protein family 1
GIS01_10480	ENOG4105D38	putrescine abc transporter
GIS01_10485	ENOG4105F38	ABC transporter, permease
GIS01_10505	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
GIS01_10510	ENOG4105Q9Y	Universal stress protein
GIS01_10515	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
GIS01_10530	ENOG4105C59	p-type ATPase
GIS01_10540	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
GIS01_10555	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
GIS01_10565	ENOG4108ZGC	gaf domain protein
GIS01_10570	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
GIS01_10575	ENOG4105CN1	protease
GIS01_10580	ENOG4105CD8	aminopeptidase N
GIS01_10590	ENOG4105C7I	Dehydrogenase
GIS01_10595	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
GIS01_10600	ENOG4108T7E	Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)
GIS01_10605	ENOG4105NRA	50s ribosomal protein l31 type b
GIS01_10615	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
GIS01_10625	ENOG4105C5H	ABC transporter
GIS01_10630	ENOG4105WFT	During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)
GIS01_10635	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
GIS01_10640	ENOG4105DAN	ATP-dependent protease
GIS01_10670	ENOG4105X2V	dna damage-inducible protein
GIS01_10675	ENOG4108KTS	Acetyltransferase and hydrolase with the alpha beta hydrolase fold
GIS01_10680	ENOG4105PDP	Short chain dehydrogenase
GIS01_10720	ENOG4105DXD	2-methylcitrate dehydratase
GIS01_10725	ENOG4105BZN	citrate synthase
GIS01_10730	ENOG4105CR4	methylisocitrate lyase
GIS01_10740	ENOG4105F1S	paraquat-inducible protein a
GIS01_10745	ENOG4105DY2	Paraquat-inducible protein b
GIS01_10750	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GIS01_10765	ENOG4105F8V	Hydrolase, tatD family
GIS01_10770	ENOG4107QRG	dna polymerase iii
GIS01_10775	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
GIS01_10780	ENOG4105HHA	aminodeoxychorismate lyase
GIS01_10785	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
GIS01_10790	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
GIS01_10795	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
GIS01_10800	ENOG4105CHR	reductase
GIS01_10805	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
GIS01_10810	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
GIS01_10815	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
GIS01_10820	ENOG4105VGS	50s ribosomal protein l32
GIS01_10825	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
GIS01_10965	ENOG4105BZU	Histidine kinase
GIS01_11025	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_11120	ENOG41076J9	exonuclease VIII
GIS01_11130	ENOG4108Z33	Thiol disulfide Interchange Protein
GIS01_11140	ENOG4107R08	Integrase
GIS01_11145	ENOG4108UHJ	MAF-like protein
GIS01_11155	ENOG4105EI2	Pseudouridine synthase
GIS01_11160	ENOG4105C03	ribonuclease
GIS01_11170	ENOG4105CJ3	phosphate transporter
GIS01_11175	ENOG4105DHP	deoxycytidine triphosphate deaminase
GIS01_11180	ENOG4105DBI	uridine monophosphokinase
GIS01_11185	ENOG4105D1F	ATP-binding protein
GIS01_11190	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
GIS01_11200	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
GIS01_11205	ENOG4108N3W	hemolysin secretion protein
GIS01_11210	ENOG4105DR4	Methyltransferase
GIS01_11215	ENOG4105FAT	Acyl-transferase
GIS01_11225	ENOG4105D4F	Synthesizes selenophosphate from selenide and ATP (By similarity)
GIS01_11230	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
GIS01_11235	ENOG4105C5X	domain protein
GIS01_11245	ENOG4105CEY	Amp-dependent synthetase and ligase
GIS01_11250	ENOG4108MXF	Alpha Beta Hydrolase
GIS01_11260	ENOG41072GX	Peptidase M22 Glycoprotease
GIS01_11265	ENOG4105DVT	helicase
GIS01_11275	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
GIS01_11285	ENOG4105CIH	Imidazole acetol-phosphate transaminase
GIS01_11290	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
GIS01_11295	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
GIS01_11300	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
GIS01_11305	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
GIS01_11310	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
GIS01_11320	ENOG4105BZU	Histidine kinase
GIS01_11325	ENOG4105CEY	Amp-dependent synthetase and ligase
GIS01_11335	ENOG4107MBR	17 kDa surface antigen
GIS01_11340	ENOG4108UTP	(2Fe-2S)-binding domain protein
GIS01_11345	ENOG4108HR6	Dehydrogenase
GIS01_11350	ENOG4105C7W	Xanthine dehydrogenase
GIS01_11355	ENOG4105C7N	Xanthine uracil vitamin C permease
GIS01_11360	ENOG4107QUY	Guanine deaminase
GIS01_11365	ENOG4105C2W	permease
GIS01_11370	ENOG4105C7W	Xanthine dehydrogenase
GIS01_11375	ENOG410873Y	FAD binding domain in molybdopterin dehydrogenase
GIS01_11380	ENOG4107UUR	Chlorohydrolase aminohydrolase
GIS01_11385	ENOG4105BZ8	glutamate synthase
GIS01_11395	ENOG4105MFX	4-diphosphocytidyl-2c-methyl-d-erythritol synthase
GIS01_11400	ENOG4105MJ6	selenium-dependent hydroxylase accessory protein YqeC
GIS01_11405	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
GIS01_11415	ENOG4108Q5Y	Membrane
GIS01_11420	ENOG4105C5B	carbamate kinase
GIS01_11430	ENOG4107S4Y	M20 DapE family protein YgeY
GIS01_11435	ENOG4107RCH	Diaminopropionate ammonia-lyase
GIS01_11440	ENOG4105IW6	Carbamoyltransferase
GIS01_11475	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
GIS01_11485	ENOG4105K6T	rare lipoprotein A
GIS01_11490	ENOG4105DUC	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)
GIS01_11495	ENOG4105DAH	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)
GIS01_11500	ENOG4105GHU	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)
GIS01_11505	ENOG4106371	Methyltransferase
GIS01_11510	ENOG4107S90	membrAne
GIS01_11520	ENOG4105CTQ	phosphohexokinase
GIS01_11525	ENOG4105CK2	sodium dicarboxylate symporter
GIS01_11530	ENOG4105NBK	UPF0345 protein
GIS01_11535	ENOG4105EJQ	L-serine dehydratase
GIS01_11540	ENOG4105EJQ	L-serine dehydratase
GIS01_11545	ENOG4105VNG	YcgL domain-containing protein
GIS01_11550	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
GIS01_11555	ENOG4107QMS	site-determining protein
GIS01_11560	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
GIS01_11570	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
GIS01_11575	ENOG4105XW2	UPF0263 protein
GIS01_11610	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
GIS01_11615	ENOG4108SXK	Transporter Drug Metabolite Exporter family
GIS01_11620	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
GIS01_11625	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
GIS01_11635	ENOG4108R6K	riboflavin synthase, subunit alpha
GIS01_11645	ENOG4105W1I	UPF0253 protein
GIS01_11650	ENOG4107QI1	Mate efflux family protein
GIS01_11680	ENOG4108JUB	Transcriptional regulator
GIS01_11695	ENOG4108VWS	Yaeq family
GIS01_11710	ENOG4105DKR	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
GIS01_11715	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
GIS01_11720	ENOG4105DQR	SNARE associated Golgi
GIS01_11730	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
GIS01_11745	ENOG4105D0C	transport protein
GIS01_11755	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
GIS01_11760	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
GIS01_11775	ENOG4105CEE	C4-dicarboxylate transporter
GIS01_11790	ENOG4108VKG	metal-dependent hydrolase
GIS01_11805	ENOG4105CQ2	DNA polymerase
GIS01_11830	ENOG4105D1S	lipid A biosynthesis
GIS01_11835	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
GIS01_11845	ENOG4105DUM	transcriptional regulator, lysR family
GIS01_11850	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
GIS01_11855	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
GIS01_11860	ENOG4107QMP	dna polymerase iii subunits gamma and tau
GIS01_11865	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
GIS01_11870	ENOG4105WD1	Membrane
GIS01_11875	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
GIS01_11890	ENOG4105PAD	Hydrolase
GIS01_11895	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
GIS01_11920	ENOG4105CPB	ATP-dependent endonuclease of the OLD family
GIS01_11935	ENOG4105VP0	transcriptional regulator, lysR family
GIS01_11940	ENOG4105EJ9	Membrane
GIS01_11945	ENOG4106IUH	DTW domain containing protein
GIS01_11950	ENOG4105E2R	ROK family
GIS01_11955	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_11960	ENOG4105K5B	UPF0225 protein
GIS01_11965	ENOG4107R5Y	anaerobic glycerol-3-phosphate dehydrogenase, subunit A
GIS01_11970	ENOG4108KJ0	anaerobic glycerol-3-phosphate dehydrogenase, subunit B
GIS01_11975	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
GIS01_11990	ENOG4105JJ8	Cytochrome c nitrite reductase, pentaheme subunit
GIS01_11995	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
GIS01_12000	ENOG4105DVI	reductase, NrfD
GIS01_12005	ENOG4105DA4	cytochrome c-type biogenesis protein
GIS01_12010	ENOG4107QX9	Thiol disulfide interChange protein
GIS01_12015	ENOG4108DMF	Cytochrome C biogenesis protein
GIS01_12025	ENOG4108KAZ	Involved in phosphonate degradation (By similarity)
GIS01_12030	ENOG4108JPW	Aminotransferase
GIS01_12035	ENOG4107STF	Involved in phosphonate degradation (By similarity)
GIS01_12045	ENOG4105C4Y	ABC transporter
GIS01_12055	ENOG4107RCV	ABC transporter, permease
GIS01_12060	ENOG4105CJP	fad dependent oxidoreductase
GIS01_12075	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
GIS01_12080	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
GIS01_12085	ENOG4105C7S	Dehydrogenase
GIS01_12090	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
GIS01_12095	ENOG4105E33	succinate dehydrogenase
GIS01_12100	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
GIS01_12105	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
GIS01_12110	ENOG4108UTY	succinate dehydrogenase, cytochrome b556 subunit
GIS01_12115	ENOG4105BZN	citrate synthase
GIS01_12125	ENOG4105K5X	acetyltransferase
GIS01_12145	ENOG4107XGF	functions in a salvage pathway. Uses pyridoxamine (By similarity)
GIS01_12160	ENOG4105WQ3	Rna-binding protein
GIS01_12170	ENOG4105BZ1	(ABC) transporter
GIS01_12175	ENOG4105BZ1	(ABC) transporter
GIS01_12180	ENOG4105BZU	Histidine kinase
GIS01_12185	ENOG4105K63	Thioredoxin
GIS01_12190	ENOG4105C8P	)-transporter
GIS01_12195	ENOG4107QQN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
GIS01_12210	ENOG4108IPJ	Membrane
GIS01_12220	ENOG4108BY2	phosphohistidine phosphatase
GIS01_12225	ENOG4107QXK	peptidase
GIS01_12230	ENOG4105FQ6	thiopurine methyltransferase
GIS01_12245	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
GIS01_12250	ENOG4108JJB	ABC transporter
GIS01_12260	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GIS01_12265	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GIS01_12275	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
GIS01_12280	ENOG4105FDP	GntR family transcriptional regulator
GIS01_12290	ENOG4105C8I	hydrolase, family 38
GIS01_12295	ENOG4105CPF	Cell wall formation (By similarity)
GIS01_12305	ENOG4108V06	Glutathione peroxidase
GIS01_12310	ENOG4105C1J	atp-dependent rna helicase
GIS01_12315	ENOG4105D4P	Coproporphyrinogen iii oxidase
GIS01_12320	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_12325	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
GIS01_12330	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
GIS01_12335	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
GIS01_12340	ENOG4105C10	Electron transfer flavoprotein
GIS01_12345	ENOG4105BZJ	Electron transfer flavoprotein
GIS01_12350	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
GIS01_12355	ENOG4107QUT	magnesium and cobalt transport protein CorA
GIS01_12360	ENOG4105QZU	Inner membrane protein YfeZ
GIS01_12370	ENOG4105F3T	(LipO)protein
GIS01_12385	ENOG4105BZU	Histidine kinase
GIS01_12400	ENOG4107RE1	Inosine-guanosine kinase
GIS01_12410	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
GIS01_12415	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
GIS01_12420	ENOG4105FR9	TRNA-(Ms 2 io 6 A)-hydroxylase
GIS01_12425	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
GIS01_12430	ENOG4105E96	Colicin v production protein
GIS01_12435	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
GIS01_12440	ENOG4105D1H	recombination factor protein RarA
GIS01_12445	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
GIS01_12450	ENOG4105CNU	cell division protein FtsK
GIS01_12455	ENOG4105EW9	transcriptional regulator AsnC family
GIS01_12460	ENOG4105DCF	alanine dehydrogenase
GIS01_12465	ENOG4105C3M	thioredoxin reductase
GIS01_12470	ENOG4105BZU	Histidine kinase
GIS01_12475	ENOG4107MBR	17 kDa surface antigen
GIS01_12480	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
GIS01_12485	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
GIS01_12490	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
GIS01_12495	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GIS01_12500	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
GIS01_12505	ENOG4105VEQ	Cold shock protein
GIS01_12510	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
GIS01_12530	ENOG4107EXC	regulatoR
GIS01_12535	ENOG4105JJR	Histidine kinase
GIS01_12545	ENOG4105FF5	Membrane
GIS01_12560	ENOG4108RMJ	sensory transduction regulator
GIS01_12570	ENOG4107104	thymidine kinase
GIS01_12575	ENOG4107S6Z	Na H antiporter
GIS01_12585	ENOG4108WBT	adenosyltransferase
GIS01_12590	ENOG4105VRT	cytoplasmic protein
GIS01_12595	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
GIS01_12600	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
GIS01_12615	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
GIS01_12620	ENOG4105CFV	Tetratricopeptide repeat protein
GIS01_12630	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
GIS01_12635	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
GIS01_12640	ENOG4105CAT	Cytidine monophosphate kinase
GIS01_12645	ENOG4108JEN	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
GIS01_12650	ENOG4107R11	Transcriptional regulator
GIS01_12655	ENOG4105DUM	transcriptional regulator, lysR family
GIS01_12660	ENOG4108SC4	)-transporter
GIS01_12675	ENOG4108DBC	nitroreductase
GIS01_12680	ENOG4105CFC	Transporter
GIS01_12685	ENOG4105BZU	Histidine kinase
GIS01_12690	ENOG4105CBN	LysR family transcriptional regulator
GIS01_12695	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_12710	ENOG4108RU0	short-chain dehydrogenase reductase
GIS01_12720	ENOG4107RGM	aldo keto reductase
GIS01_12725	ENOG4105VFU	Rna-binding protein
GIS01_12735	ENOG4105CDA	abc transporter atp-binding protein
GIS01_12740	ENOG4105EAD	ABC transporter
GIS01_12745	ENOG4106TNF	Periplasmic binding protein
GIS01_12750	ENOG4105EZ7	amino acid ABC transporter
GIS01_12755	ENOG4105HPZ	Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)
GIS01_12765	ENOG4105HA9	of methanol dehydrogenase type
GIS01_12780	ENOG4105E14	MotA TolQ exbB proton channel
GIS01_12785	ENOG4105ER2	Ompa motb domain protein
GIS01_12795	ENOG4105CUG	Oligopeptidase b
GIS01_12815	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GIS01_12820	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_12825	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_12830	ENOG4105GKE	subunit e
GIS01_12835	ENOG4107QIZ	NADH dehydrogenase
GIS01_12840	ENOG4108IEH	NADH dehydrogenase subunit g
GIS01_12845	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
GIS01_12850	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_12855	ENOG4107UFS	subunit j
GIS01_12860	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_12865	ENOG4105D65	subunit l
GIS01_12870	ENOG4105C8S	subunit m
GIS01_12875	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
GIS01_12885	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_12890	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_12895	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
GIS01_12900	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
GIS01_12905	ENOG4105VPD	cellular component movement
GIS01_12910	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
GIS01_12915	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
GIS01_12920	ENOG4105N21	Membrane
GIS01_12925	ENOG4105CUT	histidyl-tRNA synthetase
GIS01_12930	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
GIS01_12935	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
GIS01_12945	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
GIS01_12950	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
GIS01_12965	ENOG4108ZIT	Ferredoxin, 2FE-2S
GIS01_12970	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
GIS01_12975	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
GIS01_12980	ENOG4108Z4V	iron-sulfur cluster assembly
GIS01_12985	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
GIS01_12990	ENOG4105C3J	Cysteine desulfurase
GIS01_12995	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
GIS01_13000	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
GIS01_13010	ENOG4105XPQ	lipid carrier protein
GIS01_13015	ENOG4105CFP	Peptidase U32
GIS01_13020	ENOG4106RZ4	Peptidase U32
GIS01_13035	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GIS01_13040	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
GIS01_13045	ENOG4105VIE	preprotein translocase, subunit YajC
GIS01_13050	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
GIS01_13055	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
GIS01_13060	ENOG4105W87	Cbs domain
GIS01_13065	ENOG4105D3R	alkyl hydroperoxide reductase
GIS01_13105	ENOG4105C42	Type I secretion membrane fusion protein (HlyD
GIS01_13110	ENOG4108JJA	ABC, transporter
GIS01_13115	ENOG4105N5T	Radical SAM Protein
GIS01_13120	ENOG4105CBC	glutamate synthase
GIS01_13125	ENOG4105BZ8	glutamate synthase
GIS01_13135	ENOG4105C1J	atp-dependent rna helicase
GIS01_13160	ENOG4108ZJT	translation initiation factor, Sui1
GIS01_13220	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
GIS01_13230	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
GIS01_13240	ENOG4105Y3U	Transglycosylase-associated protein
GIS01_13245	ENOG4105DHQ	Histidine kinase
GIS01_13290	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
GIS01_13295	ENOG4105WH1	Two component transcriptional regulator luxr family
GIS01_13300	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
GIS01_13305	ENOG4105W49	UPF0434 protein
GIS01_13310	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
GIS01_13320	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
GIS01_13335	ENOG4105CGF	Aromatic amino acid aminotransferase
GIS01_13360	ENOG4105CGK	Exodeoxyribonuclease III
GIS01_13380	ENOG4108JJB	ABC transporter
GIS01_13385	ENOG4108JJB	ABC transporter
GIS01_13410	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
GIS01_13415	ENOG4108IJF	Heavy metal efflux pump, CzcA
GIS01_13425	ENOG4105S10	periplasmic binding protein
GIS01_13430	ENOG4105E0A	ABC, transporter
GIS01_13435	ENOG4105TVJ	transport system, permease
GIS01_13440	ENOG4105DQ5	transport system permease protein
GIS01_13445	ENOG4105D05	Receptor
GIS01_13450	ENOG4105Q26	Siderophore-interacting protein
GIS01_13455	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_13465	ENOG4107RZZ	dna polymerase iii epsilon subunit
GIS01_13470	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
GIS01_13475	ENOG4105D1A	Methyltransferase
GIS01_13480	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
GIS01_13485	ENOG4105E9H	Lytic Murein transglycosylase
GIS01_13500	ENOG4105KR1	Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)
GIS01_13510	ENOG4105BZU	Histidine kinase
GIS01_13515	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
GIS01_13520	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
GIS01_13525	ENOG4105BZS	acriflavin resistance protein
GIS01_13545	ENOG4105CVI	Transcriptional regulator
GIS01_13550	ENOG4108WFC	UPF0438 protein yifE
GIS01_13555	ENOG4108QSZ	General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)
GIS01_13560	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
GIS01_13565	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
GIS01_13570	ENOG4105E98	transcriptional regulator DeoR family
GIS01_13575	ENOG4105CXY	transporter
GIS01_13580	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
GIS01_13585	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
GIS01_13590	ENOG41069D7	Methyl-accepting chemotaxis
GIS01_13600	ENOG4105HEI	LysR family (Transcriptional regulator
GIS01_13625	ENOG4105CV8	reductase
GIS01_13635	ENOG4105F27	Major Facilitator
GIS01_13640	ENOG4108X0B	nad(p)h dehydrogenase (quinone)
GIS01_13655	ENOG4105E18	UPF0276 protein
GIS01_13675	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GIS01_13680	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GIS01_13685	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
GIS01_13695	ENOG4108Q2J	Inner membrane protein YebE
GIS01_13705	ENOG4106428	Protein of unknown function (DUF2496)
GIS01_13720	ENOG4105DJ2	Major Facilitator Superfamily
GIS01_13725	ENOG4105FE9	pseudouridine synthase
GIS01_13735	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
GIS01_13745	ENOG4105CFI	type iii restriction protein res subunit
GIS01_13750	ENOG4105DGN	Electron transport complex
GIS01_13755	ENOG4108R3D	Electron transport complex
GIS01_13765	ENOG4105D6A	Electron transport complex
GIS01_13775	ENOG4105DZB	Electron transport complex
GIS01_13780	ENOG4105CSM	endonuclease III
GIS01_13785	ENOG4108UYE	Lactoylglutathione lyase
GIS01_13790	ENOG4105EIY	sodium-type flagellar protein motY
GIS01_13820	ENOG4107QS8	(LipO)protein
GIS01_13825	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
GIS01_13830	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
GIS01_13835	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
GIS01_13850	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
GIS01_13855	ENOG4105E66	phosphoriboisomerase A
GIS01_13860	ENOG4108JQ1	Dehydrogenase
GIS01_13865	ENOG41080IJ	Diacylglycerol kinase
GIS01_13870	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
GIS01_13875	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
GIS01_13880	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
GIS01_13895	ENOG4105CZX	twitching motility protein
GIS01_13905	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
GIS01_13910	ENOG4105DU1	integral membrane protein, terc
GIS01_13915	ENOG4108JQ7	(ABC) transporter
GIS01_13920	ENOG4105C3U	ABC transporter
GIS01_13925	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
GIS01_13930	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
GIS01_13935	ENOG4107QSI	ABC, transporter
GIS01_13940	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
GIS01_13945	ENOG4108EKI	Dehydrogenase
GIS01_13955	ENOG4105CDY	transcriptional regulatory protein
GIS01_13960	ENOG4105C9M	aspartyl-trna synthetase
GIS01_13970	ENOG41081XQ	Conserved Protein
GIS01_13975	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
GIS01_13980	ENOG4105PFA	Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity)
GIS01_14000	ENOG4105D3R	alkyl hydroperoxide reductase
GIS01_14005	ENOG4105C5Q	Transcriptional regulator
GIS01_14010	ENOG4108QBX	(LipO)protein
GIS01_14020	ENOG4105W8I	Transcriptional regulator
GIS01_14030	ENOG4105BZC	d-serine deaminase
GIS01_14040	ENOG4108HMX	isocitrate dehydrogenase (NADP)
GIS01_14045	ENOG4106R3P	AraC family transcriptional regulator
GIS01_14050	ENOG4105EIP	mannose-6-phosphate isomerase
GIS01_14055	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_14060	ENOG4105DM4	PTS System
GIS01_14075	ENOG4105KAF	membrAne
GIS01_14105	ENOG4107RGH	Aldehyde dehydrogenase
GIS01_14110	ENOG4107Z3H	Transcriptional regulator, TetR family
GIS01_14140	ENOG4105UQX	Mate efflux family protein
GIS01_14150	ENOG4105Z2P	Protein of unknown function (DUF465)
GIS01_14155	ENOG4105WEM	extracellular solute-binding protein
GIS01_14160	ENOG4105BZU	Histidine kinase
GIS01_14165	ENOG4108YXG	UPF0502 protein
GIS01_14190	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
GIS01_14200	ENOG4105C8P	)-transporter
GIS01_14210	ENOG4105EBA	Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity)
GIS01_14215	ENOG4107TT5	NLP P60 protein
GIS01_14220	ENOG4107YAK	holo-(acyl carrier protein) synthase 2
GIS01_14225	ENOG4107QR8	Thioredoxin
GIS01_14235	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
GIS01_14240	ENOG4105CIY	formyltetrahydrofolate deformylase
GIS01_14250	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
GIS01_14265	ENOG4105E4C	Lytic transglycosylase catalytic
GIS01_14270	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
GIS01_14280	ENOG4105CHM	Aminotransferase
GIS01_14285	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
GIS01_14290	ENOG4105RKW	reductase (By
GIS01_14375	ENOG4105EFV	Major head subunit
GIS01_14380	ENOG4108TVE	i protein
GIS01_14410	ENOG4105QIB	mu-like prophage Flumu protein gp29
GIS01_14415	ENOG4105CF2	Mu-like prophage FluMu protein GP28
GIS01_14420	ENOG4108Z6H	mu-like prophage Flumu protein gp27
GIS01_14545	ENOG4105M7P	phage repressor
GIS01_14560	ENOG4105WWK	YheO domain protein
GIS01_14565	ENOG4105CEM	UPF0597 protein
GIS01_14570	ENOG4105KME	endoribonuclease L-psp
GIS01_14575	ENOG4105C44	Serine transporter
GIS01_14595	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
GIS01_14600	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
GIS01_14615	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
GIS01_14625	ENOG4108YYC	ycei family
GIS01_14630	ENOG4105CC0	LysR family Transcriptional regulator
GIS01_14640	ENOG4105CKU	formyltetrahydrofolate synthetase
GIS01_14645	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_14650	ENOG4105EUJ	GTP cyclohydrolase i
GIS01_14655	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GIS01_14660	ENOG4105D06	uba thif-type nad fad binding protein
GIS01_14675	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
GIS01_14680	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
GIS01_14685	ENOG4105E0C	molybdate abc transporter
GIS01_14690	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
GIS01_14695	ENOG4108ZAF	Molybdopterin
GIS01_14700	ENOG4105M00	molybdopterin converting factor, subunit 1
GIS01_14705	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GIS01_14710	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
GIS01_14715	ENOG4105CUW	cytochrome C-TYPE protein
GIS01_14725	ENOG4105GXZ	Ferredoxin-type protein NapH
GIS01_14730	ENOG4108BGM	Quinol dehydrogenase periplasmic component
GIS01_14735	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
GIS01_14750	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
GIS01_14755	ENOG4105BZU	Histidine kinase
GIS01_14760	ENOG4105WH1	Two component transcriptional regulator luxr family
GIS01_14770	ENOG4105BZU	Histidine kinase
GIS01_14780	ENOG4105CHW	UPF0052 protein
GIS01_14790	ENOG4105E7A	Glutamine amidotransferase
GIS01_14795	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
GIS01_14800	ENOG4107QPN	acyl-Coa dehydrogenase
GIS01_14805	ENOG4105CH2	amidohydrolase
GIS01_14810	ENOG4105VDB	UPF0125 protein
GIS01_14815	ENOG4108Z1B	Cyclase dehydrase
GIS01_14820	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
GIS01_15050	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
GIS01_15060	ENOG4105NY2	NinB protein
GIS01_15085	ENOG4105DVF	Cytosine-specific methyltransferase
GIS01_15120	ENOG41076J9	exonuclease VIII
GIS01_15150	ENOG4105DH7	May be involved in recombination (By similarity)
GIS01_15215	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GIS01_15220	ENOG4105BZU	Histidine kinase
GIS01_15225	ENOG4105BZU	Histidine kinase
GIS01_15230	ENOG4108IEG	Formate dehydrogenase Alpha subunit
GIS01_15240	ENOG4107SSZ	Phosphatase
GIS01_15250	ENOG4107QPN	acyl-Coa dehydrogenase
GIS01_15255	ENOG4105BZS	acriflavin resistance protein
GIS01_15265	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
GIS01_15300	ENOG41066XE	Type III export protein
GIS01_15330	ENOG4108KB1	transcriptional regulator, arac family
GIS01_15345	ENOG4106V6P	Exoenzyme S synthesis protein C
GIS01_15465	ENOG4105C87	Aminotransferase class I and II
GIS01_15470	ENOG4105CI1	PTS System
GIS01_15475	ENOG4107P2S	Transcriptional regulator
GIS01_15485	ENOG4108SU4	UPF0309 protein
GIS01_15500	ENOG4105DM4	PTS System
GIS01_15505	ENOG4105CXY	transporter
GIS01_15510	ENOG4108YRF	PTS System
GIS01_15520	ENOG4108R99	pseudouridine synthase
GIS01_15530	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
GIS01_15535	ENOG41075W9	High frequency lysogenization protein HflD homolog
GIS01_15540	ENOG4107QTF	adenylosuccinate lyase
GIS01_15545	ENOG4105EZE	Cupin 4 family protein
GIS01_15565	ENOG4108TGY	Glutathione S-transferase
GIS01_15570	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
GIS01_15615	ENOG4105M2J	Glutaredoxin
GIS01_15620	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
GIS01_15625	ENOG410903C	(LipO)protein
GIS01_15635	ENOG4105KWW	Biogenesis protein
GIS01_15640	ENOG4107QX9	Thiol disulfide interChange protein
GIS01_15645	ENOG4105DA4	cytochrome c-type biogenesis protein
GIS01_15650	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
GIS01_15655	ENOG4105X3C	heme exporter protein
GIS01_15660	ENOG41060IM	Heme exporter protein
GIS01_15665	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
GIS01_15680	ENOG4108V3W	Chemotaxis protein, CheW
GIS01_15690	ENOG4107QJE	Chromosome Partitioning Protein
GIS01_15695	ENOG4108SEK	ompa motb domain protein
GIS01_15700	ENOG4105E14	MotA TolQ exbB proton channel
GIS01_15705	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
GIS01_15710	ENOG4105CBS	Chea signal transduction histidine kinase
GIS01_15715	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
GIS01_15720	ENOG4108VYJ	response regulator receiver protein
GIS01_15725	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
GIS01_15735	ENOG4105FZW	flagellar biosynthesis regulator FlhF
GIS01_15740	ENOG4105D7B	Flagellar biosynthesis protein flha
GIS01_15745	ENOG4105D00	flagellar biosynthetic protein flhB
GIS01_15750	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
GIS01_15755	ENOG4105VS8	Flagellar biosynthetic protein fliq
GIS01_15760	ENOG4105CN7	Flagellar biosynthetic protein FliP
GIS01_15765	ENOG4105VTB	flagellar biosynthesis protein fliO
GIS01_15770	ENOG4105DD5	Flagellar motor switch protein
GIS01_15775	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
GIS01_15795	ENOG4108JIR	Flagellum-specific ATP synthase
GIS01_15805	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
GIS01_15810	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
GIS01_15815	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
GIS01_15835	ENOG4105CA9	Pyruvate kinase
GIS01_15840	ENOG4106KNT	transcriptional regulator
GIS01_15845	ENOG4105CHC	glucokinase (EC 2.7.1.2)
GIS01_15870	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_15875	ENOG4106TNF	Periplasmic binding protein
GIS01_15880	ENOG4105C2W	permease
GIS01_15895	ENOG4107R1I	NAD-dependent malic enzyme
GIS01_15915	ENOG4105QAX	Iron-sulfur
GIS01_15920	ENOG4108IEG	Formate dehydrogenase Alpha subunit
GIS01_15920	ENOG4108IEG	Formate dehydrogenase Alpha subunit
GIS01_15960	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
GIS01_15970	ENOG4105BZU	Histidine kinase
GIS01_15975	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_15985	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
GIS01_15990	ENOG4108IUZ	ABC transporter
GIS01_15995	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
GIS01_16000	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
GIS01_16005	ENOG4105DR8	Membrane
GIS01_16010	ENOG4108ESY	Metal dependent phosphohydrolase
GIS01_16020	ENOG4107SDU	Methyl-accepting chemotaxis
GIS01_16050	ENOG4105XIQ	Protein of unknown function (DUF2517)
GIS01_16070	ENOG4105BZU	Histidine kinase
GIS01_16085	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
GIS01_16095	ENOG4108JQ7	(ABC) transporter
GIS01_16105	ENOG4105RD7	BadF BadG BcrA BcrD
GIS01_16110	ENOG4105E2D	ec 3.2.1.52
GIS01_16115	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
GIS01_16125	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
GIS01_16130	ENOG4105EY2	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)
GIS01_16155	ENOG4105BZU	Histidine kinase
GIS01_16160	ENOG41068CG	regulatoR
GIS01_16190	ENOG4108NJZ	Sensory box GGDEF EAL domain protein
GIS01_16195	ENOG4105CFP	Peptidase U32
GIS01_16200	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
GIS01_16210	ENOG41090EX	DsrE family
GIS01_16215	ENOG4105BZU	Histidine kinase
GIS01_16220	ENOG4105E5W	Transporter
GIS01_16225	ENOG4105ERU	peptidase
GIS01_16230	ENOG4105UBK	short-chain dehydrogenase reductase
GIS01_16235	ENOG4105C5Q	Transcriptional regulator
GIS01_16245	ENOG4105C87	Aminotransferase class I and II
GIS01_16260	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
GIS01_16265	ENOG4108V1U	phospholipid-binding protein
GIS01_16285	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
GIS01_16295	ENOG4108VKA	Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity)
GIS01_16300	ENOG4105CK2	sodium dicarboxylate symporter
GIS01_16305	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
GIS01_16310	ENOG41063JG	Transcriptional regulator
GIS01_16320	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
GIS01_16325	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
GIS01_16330	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
GIS01_16335	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
GIS01_16340	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
GIS01_16350	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
GIS01_16355	ENOG4105CGH	5'-nucleotidase
GIS01_16360	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
GIS01_16365	ENOG4105C3G	gtp-binding protein
GIS01_16410	ENOG4107QWE	)-transporter
GIS01_16415	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
GIS01_16420	ENOG4108I5U	Uridine phosphorylase
GIS01_16430	ENOG41060QA	UPF0267 protein
GIS01_16440	ENOG4105CG3	alpha amylase, catalytic region
GIS01_16445	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
GIS01_16455	ENOG4107VXZ	Hydrolase
GIS01_16470	ENOG4105C26	Dehydrogenase
GIS01_16480	ENOG4105C8Y	Acetylornithine aminotransferase
GIS01_16485	ENOG4105DDQ	anthranilate synthase
GIS01_16495	ENOG4105C31	Tryptophanyl-tRNA synthetase
GIS01_16500	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
GIS01_16505	ENOG4105DJV	ribulose-phosphate 3-epimerase
GIS01_16510	ENOG4105DFE	Dna adenine methylase
GIS01_16520	ENOG4105D49	3-dehydroquinate synthase
GIS01_16525	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
GIS01_16530	ENOG4105E4G	Type IV pilus
GIS01_16555	ENOG4108JQC	penicillin-binding protein 1A
GIS01_16560	ENOG4105C5Q	Transcriptional regulator
GIS01_16565	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_16580	ENOG4105EJC	lysr family transcriptional regulator
GIS01_16590	ENOG4105DR5	peptidase
GIS01_16600	ENOG4105EGS	Mechanosensitive ion channel
GIS01_16605	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
GIS01_16610	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_16620	ENOG4105E33	succinate dehydrogenase
GIS01_16625	ENOG4108WJH	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
GIS01_16630	ENOG4108VP9	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)
GIS01_16635	ENOG41074DU	domain protein
GIS01_16640	ENOG4108P2H	Inner membrane protein YjiG
GIS01_16645	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
GIS01_16655	ENOG4105T0Z	Conserved Protein
GIS01_16670	ENOG4105CJP	fad dependent oxidoreductase
GIS01_16685	ENOG4108IQE	Amp-dependent synthetase and ligase
GIS01_16695	ENOG4105EMU	Dehydrogenase
GIS01_16705	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
GIS01_16710	ENOG4105DHQ	Histidine kinase
GIS01_16730	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GIS01_16740	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
GIS01_16750	ENOG4105C5I	Dehydrogenase
GIS01_16775	ENOG4106KR7	LysR family Transcriptional regulator
GIS01_16780	ENOG4105BZU	Histidine kinase
GIS01_16785	ENOG4105VEQ	Cold shock protein
GIS01_16790	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
GIS01_16795	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
GIS01_16800	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
GIS01_16805	ENOG4105C9A	Phoh family
GIS01_16810	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
GIS01_16815	ENOG4108JU5	Magnesium and cobalt efflux protein
GIS01_16820	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
GIS01_16825	ENOG4108IUB	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
GIS01_16835	ENOG4107SWG	transcriptional regulator MERR family
GIS01_16840	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
GIS01_16850	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
GIS01_16855	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GIS01_16860	ENOG41071R3	Low-potential electron donor to a number of redox enzymes (By similarity)
GIS01_16865	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
GIS01_16875	ENOG4107PAI	alpha helical protein
GIS01_16880	ENOG4105C8T	Leucyl-tRNA synthetase
GIS01_16895	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
GIS01_16900	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
GIS01_16905	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
GIS01_16910	ENOG4105CJN	penicillin-binding protein
GIS01_16915	ENOG4105CNI	cell division protein FtsW
GIS01_16920	ENOG4105CVE	Lytic murein transglycosylase
GIS01_16925	ENOG4105K6T	rare lipoprotein A
GIS01_16930	ENOG4105DZ1	carboxypeptidase
GIS01_16935	ENOG4108Z43	UPF0250 protein
GIS01_16940	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
GIS01_16945	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
GIS01_16965	ENOG4105VUT	cytoplasmic protein
GIS01_16970	ENOG4105HDK	L-asparaginase
GIS01_16975	ENOG4105D6U	Sodium Glutamate Symporter
GIS01_16980	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_16990	ENOG4105CRK	lysyL-tRNA synthetase
GIS01_16995	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
GIS01_17000	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
GIS01_17005	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
GIS01_17015	ENOG4107XM3	UPF0442 protein
GIS01_17020	ENOG4105DWK	Membrane
GIS01_17030	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
GIS01_17040	ENOG4105SUV	lipoprotein YgdR
GIS01_17045	ENOG4107RM6	sulfurtransferase
GIS01_17050	ENOG4105CSV	Glutaminase
GIS01_17055	ENOG41090ED	Protein with unknown function (DUF469)
GIS01_17060	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
GIS01_17065	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
GIS01_17070	ENOG4105BZU	Histidine kinase
GIS01_17075	ENOG4105ECP	epimerase
GIS01_17080	ENOG4105CV6	ABC transporter, permease
GIS01_17085	ENOG4108I0Y	(ABC) transporter
GIS01_17090	ENOG4108UJV	acyl-CoA thioesterase i
GIS01_17095	ENOG4107R88	Chemotaxis protein (CheV)
GIS01_17145	ENOG4108M1A	Chitin-binding protein
GIS01_17150	ENOG4108MA4	Peptidase M66
GIS01_17165	ENOG4105BZU	Histidine kinase
GIS01_17175	ENOG4105VMP	Transcriptional regulator
GIS01_17185	ENOG4105D8G	Major Facilitator superfamily
GIS01_17210	ENOG4105PYN	Pyridoxamine 5-phosphate oxidase-related
GIS01_17215	ENOG41090JE	Utilization Protein
GIS01_17225	ENOG4105EHG	Permease protein
GIS01_17245	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
GIS01_17250	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
GIS01_17255	ENOG4105CDU	Replicative dna helicase
GIS01_17270	ENOG4108YZY	peptidylprolyl cis-trans isomerase
GIS01_17275	ENOG4105VKU	nucleicacid-binding protein
GIS01_17285	ENOG4107R88	Chemotaxis protein (CheV)
GIS01_17290	ENOG4105DNZ	Alpha Beta Hydrolase
GIS01_17300	ENOG4105YP7	UPF0270 protein
GIS01_17305	ENOG4105CJE	phosphoribulokinase (EC 2.7.1.19)
GIS01_17320	ENOG4108UKZ	OsmC family
GIS01_17325	ENOG4107RYR	Transcriptional regulator, Crp Fnr family
GIS01_17360	ENOG4105DD7	kinase (PfkB family
GIS01_17365	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
GIS01_17395	ENOG4105KQT	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)
GIS01_17400	ENOG4105BZU	Histidine kinase
GIS01_17415	ENOG4105D0C	transport protein
GIS01_17420	ENOG4108UT2	hemolysin iii
GIS01_17425	ENOG4105DY8	decarboxylase
GIS01_17430	ENOG4107835	probably involved in intracellular septation (By similarity)
GIS01_17435	ENOG4105K9H	YciI-like protein
GIS01_17440	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
GIS01_17445	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
GIS01_17450	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
GIS01_17460	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
GIS01_17465	ENOG4105C3F	Signal peptidase i
GIS01_17470	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
GIS01_17480	ENOG4105VQK	sigma E regulatory protein, MucB RseB
GIS01_17485	ENOG41069PW	sigma-e factor negative regulatory protein
GIS01_17490	ENOG4105EMN	RNA polymerase sigma factor
GIS01_17495	ENOG4108IYU	L-aspartate oxidase
GIS01_17505	ENOG4105Y75	tpr repeat protein
GIS01_17510	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
GIS01_17535	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
GIS01_17555	ENOG4105CJP	fad dependent oxidoreductase
GIS01_17560	ENOG4105D2N	Aldolase
GIS01_17565	ENOG4105BZA	Phosphoglycerate kinase
GIS01_17570	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
GIS01_17575	ENOG4105DKQ	ROK family
GIS01_17580	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
GIS01_17585	ENOG4105E09	nadh pyrophosphatase
GIS01_17590	ENOG4105C26	Dehydrogenase
GIS01_17595	ENOG4106MWK	domain protein
GIS01_17600	ENOG4105EYW	Ion transport protein
GIS01_17605	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_17615	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
GIS01_17640	ENOG4105BZU	Histidine kinase
GIS01_17685	ENOG4107QWG	2-Nitropropane dioxygenase
GIS01_17705	ENOG4105CA0	peroxidase
GIS01_17710	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
GIS01_17720	ENOG4105BZU	Histidine kinase
GIS01_17725	ENOG4105C1J	atp-dependent rna helicase
GIS01_17735	ENOG4107YH7	Beta-lactamase (EC 3.5.2.6)
GIS01_17755	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
GIS01_17760	ENOG4105DWY	Agmatine deiminase
GIS01_17780	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
GIS01_17795	ENOG4108UM1	dedA family
GIS01_17800	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
GIS01_17805	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
GIS01_17810	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
GIS01_17815	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
GIS01_17820	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
GIS01_17825	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
GIS01_17830	ENOG4105CK7	Sodium proline symporter
GIS01_17840	ENOG4107N1Q	ErfK YbiS YcfS YnhG family protein
GIS01_17845	ENOG4105CUY	Mechanosensitive ion channel
GIS01_17855	ENOG4105XEP	YhcH YjgK YiaL family protein
GIS01_17880	ENOG4107SQD	Transcriptional regulator, GntR family
GIS01_17900	ENOG4105C5H	ABC transporter
GIS01_17910	ENOG4105D6S	protein involved in catabolism of external DNA
GIS01_17955	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
GIS01_17960	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
GIS01_17965	ENOG4105DXN	mazG family
GIS01_17970	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
GIS01_17975	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GIS01_17980	ENOG4105BZU	Histidine kinase
GIS01_17985	ENOG4108W15	Protein of unknown function (DUF1456)
GIS01_17990	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
GIS01_17995	ENOG4108RMU	ferritin dps family protein
GIS01_18000	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
GIS01_18005	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
GIS01_18010	ENOG4105CMR	udp-glucose 4-epimerase
GIS01_18015	ENOG41076MN	Phosphoesterase, PA-phosphatase related
GIS01_18020	ENOG4105DFU	Cell wall formation (By similarity)
GIS01_18025	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
GIS01_18030	ENOG410630P	Transcriptional regulator
GIS01_18035	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
GIS01_18040	ENOG4105DA5	(ABC) transporter
GIS01_18045	ENOG4105E3A	(ABC) transporter
GIS01_18050	ENOG4105DCU	2-hydroxyglutaryl-CoA dehydratase
GIS01_18055	ENOG4105CIZ	coA-substrate-specific enzyme activase
GIS01_18075	ENOG4108ETY	sodium dicarboxylate symporter
GIS01_18080	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
GIS01_18085	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
GIS01_18090	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GIS01_18095	ENOG4105DJ0	Poly(A) Polymerase
GIS01_18100	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
GIS01_18105	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_18110	ENOG4105PW4	Sugar fermentation stimulation protein homolog
GIS01_18120	ENOG4105CQ7	ATP-dependent helicase
GIS01_18125	ENOG4105BZ4	penicillin-binding protein
GIS01_18130	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
GIS01_18135	ENOG4108ZBZ	Catalyzes the excretion of spermidine (By similarity)
GIS01_18140	ENOG41090TI	Catalyzes the excretion of spermidine (By similarity)
GIS01_18150	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
GIS01_18155	ENOG4105F0N	pyrophosphate phospho-hydrolase
GIS01_18170	ENOG4108UUE	Transcriptional regulator
GIS01_18205	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
GIS01_18220	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
GIS01_18230	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
GIS01_18235	ENOG4105C11	sulfate adenylyltransferase), subunit 2
GIS01_18240	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
GIS01_18245	ENOG4107QX8	SPFH domain, Band 7 family protein
GIS01_18250	ENOG4105G5H	Membrane
GIS01_18255	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_18260	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
GIS01_18265	ENOG4105DSB	aldose 1-epimerase
GIS01_18275	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
GIS01_18280	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
GIS01_18290	ENOG4105E0X	reductase
GIS01_18315	ENOG4105EW9	transcriptional regulator AsnC family
GIS01_18330	ENOG4108K4B	hydrolase
GIS01_18345	ENOG4105C8J	)-transporter
GIS01_18355	ENOG4105C8J	)-transporter
GIS01_18380	ENOG4105UFD	tol-pal system protein YbgF
GIS01_18385	ENOG4105KCK	Peptidoglycan-associated lipoprotein
GIS01_18390	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
GIS01_18400	ENOG4105M8F	Biopolymer transport protein exbD tolR
GIS01_18405	ENOG4105E02	MotA TolQ exbB proton channel
GIS01_18410	ENOG4107YD3	Thioesterase
GIS01_18415	ENOG4105KJB	cyd operon protein YbgE
GIS01_18425	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
GIS01_18430	ENOG4105C4M	(Ubiquinol oxidase) subunit I
GIS01_18435	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
GIS01_18440	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
GIS01_18445	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_18450	ENOG4108ZUB	Lysine exporter protein (Lyse ygga)
GIS01_18455	ENOG4105VJY	transcriptional regulator
GIS01_18460	ENOG4105NNS	Autoinducer synthesis protein
GIS01_18465	ENOG4105CXD	Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity)
GIS01_18470	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
GIS01_18485	ENOG4107VXZ	Hydrolase
GIS01_18490	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
GIS01_18495	ENOG4105F1S	paraquat-inducible protein a
GIS01_18500	ENOG4105DY2	Paraquat-inducible protein b
GIS01_18510	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
GIS01_18515	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
GIS01_18520	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
GIS01_18535	ENOG4105E39	Enoyl-CoA hydratase
GIS01_18540	ENOG4106WH9	Protein of unknown function (DUF2753)
GIS01_18545	ENOG4105EQK	-acetyltransferase
GIS01_18555	ENOG4107QSI	ABC, transporter
GIS01_18565	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
GIS01_18575	ENOG4105D9M	gamma-glutamylcysteine synthetase
GIS01_18585	ENOG4105W39	Membrane
GIS01_18590	ENOG4105DQ4	alcohol dehydrogenase
GIS01_18615	ENOG4105DP0	ferredoxin-NADP reductase
GIS01_18620	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
GIS01_18625	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
GIS01_18630	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
GIS01_18635	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
GIS01_18640	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
GIS01_18650	ENOG4105K70	DNA-binding protein
GIS01_18655	ENOG4105PBF	Anti-RNA polymerase sigma 70 factor
GIS01_18665	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
GIS01_18680	ENOG4105EAC	phosphoserine phosphatase
GIS01_18690	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
GIS01_18695	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
GIS01_18700	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
GIS01_18705	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
GIS01_18715	ENOG4105D9N	nucleoside
GIS01_18720	ENOG4105EYA	deoxyribonuclease
GIS01_18725	ENOG4106855	Competence protein
GIS01_18730	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
GIS01_18740	ENOG4108YZA	Nitrogen regulatory protein pii
GIS01_18745	ENOG4105C4K	Nad synthetase
GIS01_18785	ENOG4106855	Competence protein
GIS01_18790	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
GIS01_18795	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
GIS01_18800	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
GIS01_18805	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
GIS01_18810	ENOG4105DTN	riboflavin biosynthesis protein ribF
GIS01_18815	ENOG4105CJR	Integral membrane protein (MviN
GIS01_18820	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
GIS01_18825	ENOG41080HT	Transcriptional regulator, arsr family
GIS01_18830	ENOG41063Z6	transcriptional regulator, lysR family
GIS01_18840	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
GIS01_18845	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
GIS01_18850	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
GIS01_18855	ENOG4108HRM	phosphoenolpyruvate--protein phosphotransferase
GIS01_18860	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
GIS01_18865	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
GIS01_18875	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
GIS01_18880	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
GIS01_18885	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
GIS01_18890	ENOG4105K5M	30s ribosomal protein S16
GIS01_18895	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GIS01_18900	ENOG4106KVJ	cytochrome C assembly protein
GIS01_18905	ENOG4108JU6	CBS domain protein
GIS01_18915	ENOG4108EGH	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
GIS01_18920	ENOG4108UV7	flagellar protein motX
GIS01_18925	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
GIS01_18930	ENOG4105DMR	ABC, transporter
GIS01_18935	ENOG4105GBT	ABC transporter
GIS01_18940	ENOG4106PMH	Extracellular solute-binding protein family 3
GIS01_18945	ENOG4105E5Z	arginine transporter ATP-binding subunit
GIS01_18950	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
GIS01_18965	ENOG4105VZ9	UPF0235 protein
GIS01_18970	ENOG4108VIA	integral membrane protein
GIS01_18975	ENOG4105II7	pyrroline-5-carboxylate reductase
GIS01_18980	ENOG4105DFA	alanine racemase domain protein
GIS01_18985	ENOG4105CZX	twitching motility protein
GIS01_18990	ENOG4105CZX	twitching motility protein
GIS01_18995	ENOG4105D1Q	UPF0246 protein
GIS01_19010	ENOG4108YZN	class I peptide chain release factor
GIS01_19015	ENOG4108YZA	Nitrogen regulatory protein pii
GIS01_19030	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
GIS01_19035	ENOG4105EZR	dyp-type peroxidase family protein
GIS01_19040	ENOG4105VNT	transposase (IS4 family) protein
GIS01_19045	ENOG4105D9N	nucleoside
GIS01_19050	ENOG4105HEI	LysR family (Transcriptional regulator
GIS01_19065	ENOG4105BZW	Glycerate kinase
GIS01_19070	ENOG4107QQ0	gntp family
GIS01_19075	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
GIS01_19080	ENOG4105XTV	UPF0231 protein
GIS01_19110	ENOG4105C1J	atp-dependent rna helicase
GIS01_19120	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
GIS01_19150	ENOG4105CGF	Aromatic amino acid aminotransferase
GIS01_19165	ENOG41076CZ	activating enzyme
GIS01_19170	ENOG4105G0K	glycine radical enzyme YjjI family
GIS01_19185	ENOG4108JA0	Oxidoreductase, FAD NAD(P)-binding domain protein
GIS01_19200	ENOG4108N3W	hemolysin secretion protein
GIS01_19205	ENOG4108M1A	Chitin-binding protein
GIS01_19210	ENOG4107R11	Transcriptional regulator
GIS01_19215	ENOG4108IJ6	ABC transporter
GIS01_19220	ENOG4105ECW	sulfate abc transporter
GIS01_19225	ENOG4108I5D	sulfate abc transporter
GIS01_19235	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
GIS01_19240	ENOG4107PU6	Membrane
GIS01_19245	ENOG4108UW5	maltose o-acetyltransferase
GIS01_19260	ENOG4107Y3D	HAD-superfamily hydrolase subfamily IA variant 3
GIS01_19265	ENOG4107RK2	ADP-ribose diphosphatase NudE
GIS01_19270	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
GIS01_19275	ENOG4105C44	Serine transporter
GIS01_19280	ENOG4108Z7R	Chaperone CsaA
GIS01_19290	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
GIS01_19295	ENOG4105C28	cystathionine
GIS01_19300	ENOG4105CFH	Aspartokinase
GIS01_19305	ENOG4105CJ3	phosphate transporter
GIS01_19310	ENOG4107IX6	phosphate transport regulator
GIS01_19320	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
GIS01_19325	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
GIS01_19330	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
GIS01_19335	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
GIS01_19375	ENOG4105DFD	Na H antiporter
GIS01_19380	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
GIS01_19390	ENOG4105CMQ	Chloride channel
GIS01_19395	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
GIS01_19445	ENOG4108JCI	Transcriptional regulator
GIS01_19450	ENOG4105DKK	Benzoate
GIS01_19460	ENOG4105SYT	Methylenetetrahydrofolate reductase
GIS01_19475	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_19480	ENOG4105EIF	outer membrane protein W
GIS01_19485	ENOG4105BZU	Histidine kinase
GIS01_19490	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
GIS01_19510	ENOG4105P8Q	Curli production assembly transport component CsgG
GIS01_19520	ENOG4108XDW	curli assembly protein CsgE
GIS01_19525	ENOG41086KC	Transcriptional regulator
GIS01_19530	ENOG4108UUM	single-stranded DNA-binding protein
GIS01_19565	ENOG4108Z3N	Transcriptional regulator
GIS01_19620	ENOG4105VEQ	Cold shock protein
GIS01_19625	ENOG4105C7N	Xanthine uracil vitamin C permease
GIS01_19630	ENOG4105CMT	Dihydroxyacetone kinase
GIS01_19635	ENOG4108UTZ	Dihydroxyacetone kinase
GIS01_19640	ENOG4105VDH	Dihydroxyacetone kinase
GIS01_19650	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
GIS01_19660	ENOG4105IPI	Membrane
GIS01_19675	ENOG4105VEJ	Heat shock protein
GIS01_19680	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
GIS01_19685	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
GIS01_19700	ENOG4105VXR	cytoplasmic protein
GIS01_19710	ENOG4108XTF	Outer Membrane Lipoprotein
GIS01_19715	ENOG4105BZU	Histidine kinase
GIS01_19720	ENOG4106TD9	Diguanylate cyclase
GIS01_19730	ENOG4108TPP	exopolysaccharide synthesis
GIS01_19735	ENOG4105C44	Serine transporter
GIS01_19740	ENOG4105BZU	Histidine kinase
GIS01_19750	ENOG4105EQK	-acetyltransferase
GIS01_19765	ENOG4105D41	biosynthesis protein thiH
GIS01_19770	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
GIS01_19780	ENOG4105D06	uba thif-type nad fad binding protein
GIS01_19785	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
GIS01_19790	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
GIS01_19810	ENOG4105ETX	regulatoR
GIS01_19820	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
GIS01_19825	ENOG4105C3R	Methionine synthase
GIS01_19830	ENOG4105EEQ	Na H antiporter
GIS01_19865	ENOG4105CSH	Transporter
GIS01_19880	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
GIS01_19895	ENOG4105QD6	exported protein
GIS01_19900	ENOG4105C03	ribonuclease
GIS01_19905	ENOG4108Z03	MAF-like protein
GIS01_19910	ENOG4105VQ7	Rod shape-determining protein MreD
GIS01_19915	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
GIS01_19920	ENOG4105DFF	Rod shape-determining protein mreb
GIS01_19945	ENOG4106855	Competence protein
GIS01_19950	ENOG4105KHS	type IV fimbrial pilin protein
GIS01_19965	ENOG4105D7Q	type ii secretion system
GIS01_19970	ENOG4107QHF	type ii secretion system protein e
GIS01_19985	ENOG4105GVR	general secretion pathway protein D
GIS01_20015	ENOG41062P1	Diguanylate cyclase phosphodiesterase
GIS01_20020	ENOG4105CXC	rtn protein
GIS01_20025	ENOG4105EWV	Sodium calcium exchanger membrane region
GIS01_20030	ENOG4105C84	Histidine ammonia-lyase
GIS01_20035	ENOG4105CGP	Urocanate hydratase
GIS01_20040	ENOG41088SP	formiminoglutamate hydrolase
GIS01_20045	ENOG4105CI2	imidazolone-5-propionate hydrolase
GIS01_20050	ENOG4105CZE	histidine utilization repressor
GIS01_20055	ENOG41077A9	carbonic anhydrase
GIS01_20065	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
GIS01_20070	ENOG4105CAK	Cell division ATP-binding protein ftsE
GIS01_20075	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
GIS01_20080	ENOG4106H78	methyltransferase
GIS01_20105	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
GIS01_20110	ENOG4108W5M	transcriptional regulator
GIS01_20115	ENOG4105EMU	Dehydrogenase
GIS01_20130	ENOG4105CUG	Oligopeptidase b
GIS01_20145	ENOG4107RZC	phospholipase d
GIS01_20150	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
GIS01_20170	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
GIS01_20175	ENOG4105VVZ	metal-binding protein
GIS01_20190	ENOG4105JQN	Transcriptional regulator
GIS01_20205	ENOG4107FS9	Membrane
GIS01_20220	ENOG4105EJ2	Transcriptional regulator
GIS01_20260	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
GIS01_20265	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GIS01_20270	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
GIS01_20275	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
GIS01_20280	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
GIS01_20285	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
GIS01_20290	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
GIS01_20295	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
GIS01_20300	ENOG4105KME	endoribonuclease L-psp
GIS01_20305	ENOG4105WWK	YheO domain protein
GIS01_20310	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GIS01_20315	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
GIS01_20320	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
GIS01_20325	ENOG4108VZM	50s ribosomal protein L10
GIS01_20330	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
GIS01_20335	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
GIS01_20340	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
GIS01_20345	ENOG4105PM1	preprotein translocase subunit SecE
GIS01_20355	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
GIS01_20375	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
GIS01_20380	ENOG4105D4A	Cell wall formation (By similarity)
GIS01_20385	ENOG4107ZYR	domain protein
GIS01_20410	ENOG4108IYH	Dna topoisomerase
GIS01_20420	ENOG4105BZU	Histidine kinase
GIS01_20425	ENOG4105CUW	cytochrome C-TYPE protein
GIS01_20430	ENOG4107QY8	reductase
GIS01_20440	ENOG4105IFJ	Histidine kinase
GIS01_20445	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
GIS01_20475	ENOG4108UQ5	membrane protein YcdZ
GIS01_20480	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_20490	ENOG4107WP9	Histidine kinase
GIS01_20505	ENOG410642E	Short chain dehydrogenase
GIS01_20510	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
GIS01_20525	ENOG4108VVK	transcriptional Regulator, AsnC
GIS01_20530	ENOG4105CU9	asparagine synthetase A
GIS01_20535	ENOG4107T8T	UPF0173 metal-dependent hydrolase
GIS01_20540	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
GIS01_20545	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
GIS01_20550	ENOG4105C34	Pseudouridine synthase
GIS01_20555	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_20560	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
GIS01_20570	ENOG4105CEM	UPF0597 protein
GIS01_20575	ENOG4105WWK	YheO domain protein
GIS01_20585	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
GIS01_20590	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
GIS01_20595	ENOG4108I6A	alcohol dehydrogenase
GIS01_20600	ENOG4105CF7	AraC family transcriptional regulator
GIS01_20605	ENOG4105QNF	Outer membrane lipoprotein
GIS01_20610	ENOG4105C8Q	Methyl-accepting chemotaxis
GIS01_20620	ENOG4105DUM	transcriptional regulator, lysR family
GIS01_20640	ENOG4105CXT	aspartate transcarbamylase
GIS01_20645	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
GIS01_20650	ENOG410682Y	Regulates arginine biosynthesis genes (By similarity)
GIS01_20655	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
GIS01_20660	ENOG4105DBV	ornithine carbamoyltransferase
GIS01_20665	ENOG4105C5B	carbamate kinase
GIS01_20685	ENOG4105D4P	Coproporphyrinogen iii oxidase
GIS01_20690	ENOG4105XCT	Protein of unknown function (DUF2489)
GIS01_20695	ENOG4105ZR3	A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)
GIS01_20700	ENOG4106RE7	Cytochrome
GIS01_20705	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
GIS01_20715	ENOG4105E2X	shikimate dehydrogenase
GIS01_20720	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
GIS01_20725	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
GIS01_20735	ENOG4108WI1	Dna topoisomerase
GIS01_20740	ENOG4108RPN	Protein smg homolog
GIS01_20745	ENOG4105C79	DNA protecting protein DprA
GIS01_20750	ENOG4108WZM	domain protein
GIS01_20755	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
GIS01_20760	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
GIS01_20765	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
GIS01_20770	ENOG4105C1A	potassium transporter peripheral membrane
GIS01_20775	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
GIS01_20785	ENOG4105C5F	glutamine synthetase
GIS01_20795	ENOG4105CUX	Signal transduction histidine kinase
GIS01_20800	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
GIS01_20805	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
GIS01_20815	ENOG4105CGY	Dna recombination protein
GIS01_20835	ENOG4108TFM	Kinase, PfkB family
GIS01_20840	ENOG4107R11	Transcriptional regulator
GIS01_20845	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
GIS01_20850	ENOG4105C26	Dehydrogenase
GIS01_20860	ENOG4108JCI	Transcriptional regulator
GIS01_20865	ENOG4105C26	Dehydrogenase
GIS01_20875	ENOG4105FR1	rard protein
GIS01_20880	ENOG4108W2P	Methyl-accepting chemotaxis
GIS01_20885	ENOG4105CUC	YeeE YedE family protein
GIS01_20890	ENOG4105UYK	outer membrane protein a
GIS01_20895	ENOG4105C7B	Threonine dehydratase
GIS01_20900	ENOG4105C01	Dihydroxy-acid dehydratase
GIS01_20905	ENOG4105CM2	brancheD-chain amino acid aminotransferase
GIS01_20910	ENOG4105P3Y	Acetolactate synthase 2 regulatory subunit
GIS01_20925	ENOG4105C0P	Mg chelatase subunit ChlI
GIS01_20930	ENOG4106HNH	Acyl-transferase
GIS01_20935	ENOG4106HNH	Acyl-transferase
GIS01_20940	ENOG4105EWC	Purine nucleoside phosphorylase
GIS01_20950	ENOG4108RWI	nicotinamidase
GIS01_20955	ENOG4107RH7	Nicotinate phosphoribosyltransferase
GIS01_20960	ENOG4108Z33	Thiol disulfide Interchange Protein
GIS01_20965	ENOG4105E27	serine threonine protein kinase
GIS01_20975	ENOG4105PC1	Conserved Protein
GIS01_20985	ENOG4108Z6Z	Transcriptional regulator
GIS01_20995	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
GIS01_21000	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
GIS01_21005	ENOG4105DSJ	YicC domain protein
GIS01_21010	ENOG4105CC0	LysR family Transcriptional regulator
GIS01_21020	ENOG4105C4W	S-formylglutathione hydrolase
GIS01_21035	ENOG4105DHU	Bile acid
GIS01_21040	ENOG4105E5D	amino acid
GIS01_21045	ENOG4108Y51	tRNA-binding protein
GIS01_21050	ENOG4105E5D	amino acid
GIS01_21055	ENOG4105FK9	beta-D-galactosidase beta subunit
GIS01_21060	ENOG4105CNT	hydrolase family 2
GIS01_21065	ENOG4105CQ4	Transcriptional regulator
GIS01_21100	ENOG4108Z0R	Transferase
GIS01_21105	ENOG4105C2M	dna polymerase I
GIS01_21110	ENOG4108556	Isoprenoid biosynthesis protein with amidotransferase-like domain
GIS01_21115	ENOG41065UX	Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)
GIS01_21125	ENOG4105D7W	serine acetyltransferase
GIS01_21135	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
GIS01_21140	ENOG4105E0F	Histidine kinase
GIS01_21145	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
GIS01_21150	ENOG4107R73	Mate efflux family protein
GIS01_21165	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
GIS01_21170	ENOG4105E55	glycerol-3-phosphate acyltransferase
GIS01_21175	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
GIS01_21180	ENOG4105VEI	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
GIS01_21205	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
GIS01_21210	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
GIS01_21215	ENOG4105XA0	heptosyltransferase ii
GIS01_21220	ENOG4106WTF	Glycosyl transferase, family 2
GIS01_21225	ENOG4105M5K	heptosyltransferase
GIS01_21230	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
GIS01_21235	ENOG4108MJ5	VirK protein
GIS01_21240	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
GIS01_21250	ENOG4105W0E	50S ribosomal protein L33
GIS01_21255	ENOG4105KDC	50s ribosomal protein l28
GIS01_21260	ENOG4105W5Q	DNA repair protein (RadC
GIS01_21265	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
GIS01_21275	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
GIS01_21345	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
GIS01_21355	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
GIS01_21360	ENOG4105D64	Mechanosensitive ion channel
GIS01_21365	ENOG4107QP8	phosphohexose isomerase
GIS01_21370	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
GIS01_21375	ENOG4105EMY	transcriptional regulator
GIS01_21390	ENOG4105CD5	CoA-binding domain protein
GIS01_21420	ENOG4108RR8	protoporphyrinogen oxidase
GIS01_21425	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
GIS01_21430	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
GIS01_21435	ENOG4105D9Y	Splits dipeptides with a prolyl residue in the C- terminal position (By similarity)
GIS01_21440	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
GIS01_21445	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
GIS01_21450	ENOG4105CHU	acetyl-coa acetyltransferase
GIS01_21455	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
GIS01_21460	ENOG4105E0F	Histidine kinase
GIS01_21475	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
GIS01_21480	ENOG4105M4H	endoribonuclease L-psp
GIS01_21490	ENOG4108ZG0	Ompa motb domain protein
GIS01_21495	ENOG4108R3E	Dna-3-methyladenine glycosylase i
GIS01_21500	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
GIS01_21505	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
GIS01_21520	ENOG4105BZU	Histidine kinase
GIS01_21525	ENOG41072JS	exoenzyme T
GIS01_21540	ENOG4108NVR	Methyl-accepting chemotaxis
GIS01_21545	ENOG4105ETE	Transcriptional regulator (LacI family
GIS01_21550	ENOG4105CP9	extracellular ligand-binding receptor
GIS01_21555	ENOG4105C32	Amino acid ABC transporter (Permease)
GIS01_21560	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
GIS01_21565	ENOG4105C0Z	ABC transporter
GIS01_21570	ENOG4108IV0	ABC, transporter
GIS01_21575	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
GIS01_21590	ENOG4105W0Z	cytoplasmic protein
GIS01_21600	ENOG4107QK7	reductase
GIS01_21605	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
GIS01_21615	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
GIS01_21620	ENOG4105K63	Thioredoxin
GIS01_21625	ENOG4105C1J	atp-dependent rna helicase
GIS01_21630	ENOG4105C9X	ppx gppa phosphatase
GIS01_21640	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
GIS01_21645	ENOG4105BZU	Histidine kinase
GIS01_21650	ENOG4105DGW	oligopeptidase A
GIS01_21655	ENOG4105E03	chitinase
GIS01_21660	ENOG4108M1A	Chitin-binding protein
GIS01_21665	ENOG4105D52	delta-aminolevulinic acid dehydratase
GIS01_21670	ENOG4105F8V	Hydrolase, tatD family
GIS01_21675	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
GIS01_21680	ENOG4105X8U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
GIS01_21685	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
GIS01_21690	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
GIS01_21695	ENOG4105JC1	sterol-binding domain protein
GIS01_21700	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
GIS01_21705	ENOG4105WMR	Protein CrcB homolog
GIS01_21710	ENOG4105DZC	cytosine deaminase
GIS01_21715	ENOG4105DQW	permease for cytosine purines, uracil, thiamine, allantoin
GIS01_21755	ENOG410822N	TonB family
GIS01_21760	ENOG4109015	Biopolymer transport protein exbD tolR
GIS01_21780	ENOG4105VJY	transcriptional regulator
GIS01_21785	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
GIS01_21790	ENOG410804X	Transcriptional regulator
GIS01_21795	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
GIS01_21800	ENOG4105EB3	Histidine kinase
GIS01_21815	ENOG4105CT7	inner membrane cred family protein
GIS01_21820	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
GIS01_21825	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
GIS01_21830	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
GIS01_21835	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
GIS01_21840	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
GIS01_21845	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GIS01_21850	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GIS01_21855	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
GIS01_21860	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
GIS01_21870	ENOG4105FA0	parb-like partition protein
GIS01_21875	ENOG4107QJE	Chromosome Partitioning Protein
GIS01_21880	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
GIS01_21885	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
GIS01_21890	ENOG4105QTB	Flavodoxin
GIS01_21900	ENOG4105IBP	Cyclic peptide transporter
GIS01_21905	ENOG4105E0A	ABC, transporter
GIS01_21910	ENOG4105J76	Periplasmic binding protein
GIS01_21915	ENOG4105S6R	Iron-hydroxamate transporter permease subunit
GIS01_21920	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
GIS01_21925	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
GIS01_21930	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
GIS01_21935	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
GIS01_21940	ENOG4105VG0	50S ribosomal protein l34
GIS01_21945	ENOG4105CDA	abc transporter atp-binding protein
GIS01_21950	ENOG4105E5Q	amino acid AbC transporter
GIS01_21955	ENOG4105EAB	amino acid AbC transporter
GIS01_21965	ENOG4105K4U	addiction module toxin, RelE StbE family
GIS01_21995	ENOG4105BZU	Histidine kinase
GIS01_22005	ENOG4105XUP	Phage derived protein Gp49-like (DUF891)
GIS01_22080	ENOG4105ETE	Transcriptional regulator (LacI family