locus-tag	class	description
GIS01_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GIS01_00010	COG0592	DNA-directed DNA polymerase activity
GIS01_00020	COG0187	DNA topoisomerase II activity
GIS01_00030	COG2378	regulation of single-species biofilm formation
GIS01_00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GIS01_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
GIS01_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
GIS01_00055	COG3177	Filamentation induced by cAMP protein fic
GIS01_00065	COG3977	Valine--pyruvate aminotransferase
GIS01_00080	COG2814	Major facilitator Superfamily
GIS01_00085	COG0745	RESPONSE REGULATOR receiver
GIS01_00090	COG2205	protein histidine kinase activity
GIS01_00115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIS01_00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_00120	COG4191	Histidine kinase
GIS01_00125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_00130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_00135	COG1309	transcriptional regulator
GIS01_00165	COG0561	phosphatase activity
GIS01_00170	COG2267	carboxylic ester hydrolase activity
GIS01_00180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIS01_00185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GIS01_00190	COG1758	RNA polymerase activity
GIS01_00195	COG0194	GDP metabolic process
GIS01_00205	COG0859	PFAM glycosyl transferase family 9
GIS01_00210	COG3642	lipopolysaccharide core region biosynthetic process
GIS01_00250	COG0589	response to stress
GIS01_00255	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GIS01_00260	COG1528	Iron-storage protein
GIS01_00265	COG2081	HI0933 family
GIS01_00270	COG3275	phosphorelay sensor kinase activity
GIS01_00275	COG3279	Response regulator of the LytR AlgR family
GIS01_00280	COG2223	nitrite transmembrane transporter activity
GIS01_00285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GIS01_00290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GIS01_00305	COG0583	DNA-binding transcription factor activity
GIS01_00315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GIS01_00345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GIS01_00350	COG2166	iron-sulfur cluster assembly
GIS01_00355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GIS01_00370	COG3245	cytochrome
GIS01_00375	COG1063	alcohol dehydrogenase
GIS01_00390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GIS01_00400	COG3307	-O-antigen
GIS01_00435	COG1280	lysine exporter protein (LysE YggA)
GIS01_00470	COG1943	Transposase
GIS01_00480	COG2856	Zn peptidase
GIS01_00495	COG0210	DNA helicase
GIS01_00530	COG2239	Acts as a magnesium transporter
GIS01_00535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_00535	COG1648	precorrin-2 dehydrogenase activity
GIS01_00540	COG2116	formate transmembrane transporter activity
GIS01_00545	COG2146	nitrite reductase [NAD(P)H] activity
GIS01_00550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIS01_00555	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GIS01_00560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GIS01_00570	COG0018	arginyl-trna synthetase
GIS01_00580	COG1595	DNA-templated transcription, initiation
GIS01_00590	COG1968	undecaprenyl-diphosphatase activity
GIS01_00595	COG2017	converts alpha-aldose to the beta-anomer
GIS01_00600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GIS01_00605	COG1085	galactose-1-phosphate uridylyltransferase
GIS01_00610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIS01_00615	COG1609	Transcriptional regulator
GIS01_00620	COG3250	beta-galactosidase activity
GIS01_00630	COG1129	ABC transporter
GIS01_00635	COG4211	Belongs to the binding-protein-dependent transport system permease family
GIS01_00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_00660	COG0366	Alpha amylase catalytic
GIS01_00675	COG0443	Heat shock 70 kDa protein
GIS01_00680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GIS01_00685	COG3045	CreA protein
GIS01_00700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_00705	COG0174	glutamine synthetase
GIS01_00725	COG3842	ATPase activity
GIS01_00730	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_00735	COG1177	transmembrane transport
GIS01_00740	COG2258	MOSC domain
GIS01_00755	COG2050	protein possibly involved in aromatic compounds catabolism
GIS01_00760	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_00770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GIS01_00780	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GIS01_00785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GIS01_00800	COG0254	rRNA binding
GIS01_00805	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GIS01_00815	COG0702	epimerase
GIS01_00820	COG0814	amino acid
GIS01_00825	COG0281	malic enzyme
GIS01_00830	COG1295	ribonuclease BN
GIS01_00835	COG1490	D-aminoacyl-tRNA deacylase activity
GIS01_00840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GIS01_00845	COG0456	acetyltransferase
GIS01_00855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GIS01_00860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_00865	COG2610	gluconate transmembrane transporter activity
GIS01_00870	COG3265	gluconokinase activity
GIS01_00875	COG0129	dihydroxy-acid dehydratase activity
GIS01_00880	COG0800	Aldolase
GIS01_00895	COG1609	Transcriptional regulator
GIS01_00905	COG4942	peptidase
GIS01_00910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GIS01_00915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_00920	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GIS01_00925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GIS01_00930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GIS01_00930	COG0316	Belongs to the HesB IscA family
GIS01_00935	COG1040	competence protein
GIS01_00940	COG0596	Alpha beta hydrolase
GIS01_00960	COG2183	response to ionizing radiation
GIS01_00965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_00970	COG0745	RESPONSE REGULATOR receiver
GIS01_00985	COG0051	transcription antitermination factor activity, RNA binding
GIS01_00990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GIS01_00995	COG0088	Forms part of the polypeptide exit tunnel
GIS01_01000	COG0089	rRNA binding
GIS01_01005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GIS01_01010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GIS01_01015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GIS01_01020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GIS01_01025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GIS01_01030	COG0255	Belongs to the universal ribosomal protein uL29 family
GIS01_01035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GIS01_01040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GIS01_01045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GIS01_01050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GIS01_01055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GIS01_01060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GIS01_01065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GIS01_01070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GIS01_01075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GIS01_01080	COG1841	ribosomal large subunit assembly
GIS01_01085	COG0200	Binds to the 23S rRNA
GIS01_01090	COG0201	protein transport
GIS01_01095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GIS01_01100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GIS01_01105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GIS01_01110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GIS01_01115	COG0202	RNA polymerase activity
GIS01_01120	COG0203	ribosomal protein L17
GIS01_01155	COG4771	TonB-dependent receptor
GIS01_01160	COG3706	GGDEF domain
GIS01_01170	COG0745	RESPONSE REGULATOR receiver
GIS01_01190	COG0583	DNA-binding transcription factor activity
GIS01_01200	COG1741	Belongs to the pirin family
GIS01_01205	COG2259	Doxx family
GIS01_01210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GIS01_01215	COG1074	ATP-dependent DNA helicase activity
GIS01_01220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GIS01_01230	COG3706	GGDEF domain
GIS01_01260	COG1175	transmembrane transport
GIS01_01270	COG3842	ATPase activity
GIS01_01300	COG2873	o-acetylhomoserine
GIS01_01310	COG4533	DNA binding
GIS01_01315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GIS01_01330	COG5380	lipid catabolic process
GIS01_01335	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GIS01_01340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GIS01_01365	COG0753	catalase activity
GIS01_01370	COG0456	acetyltransferase
GIS01_01370	COG0454	-acetyltransferase
GIS01_01395	COG2927	DNA polymerase III (CHI subunit)
GIS01_01400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GIS01_01405	COG0795	lipopolysaccharide-transporting ATPase activity
GIS01_01410	COG0795	lipopolysaccharide-transporting ATPase activity
GIS01_01445	COG0531	amino acid
GIS01_01465	COG1494	fructose-1,6-bisphosphatase
GIS01_01480	COG2959	enzyme of heme biosynthesis
GIS01_01490	COG0181	hydroxymethylbilane synthase activity
GIS01_01495	COG3072	Adenylate cyclase
GIS01_01500	COG0400	carboxylic ester hydrolase activity
GIS01_01505	COG1965	Belongs to the frataxin family
GIS01_01515	COG0019	diaminopimelate decarboxylase activity
GIS01_01520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GIS01_01535	COG1011	Hydrolase
GIS01_01555	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GIS01_01560	COG3028	Belongs to the UPF0307 family
GIS01_01585	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_01630	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_01660	COG0312	modulator of DNA gyrase
GIS01_01665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GIS01_01670	COG5007	Belongs to the BolA IbaG family
GIS01_01680	COG2854	intermembrane phospholipid transfer
GIS01_01685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GIS01_01690	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GIS01_01695	COG1127	ABC transporter
GIS01_01700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GIS01_01700	COG0517	IMP dehydrogenase activity
GIS01_01705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GIS01_01710	COG3117	lipopolysaccharide transmembrane transporter activity
GIS01_01715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GIS01_01720	COG1137	ATPase activity
GIS01_01735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_01740	COG1660	Displays ATPase and GTPase activities
GIS01_01745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_01750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_01750	COG3711	transcriptional antiterminator
GIS01_01765	COG3964	amidohydrolase
GIS01_01795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIS01_01800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GIS01_01810	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GIS01_01815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GIS01_01820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GIS01_01825	COG0723	plastoquinol--plastocyanin reductase activity
GIS01_01830	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GIS01_01835	COG2857	Cytochrome c1
GIS01_01840	COG0625	glutathione transferase activity
GIS01_01845	COG2969	positive regulation of protein catabolic process
GIS01_01850	COG2823	Periplasmic or secreted lipoprotein
GIS01_01855	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIS01_01860	COG0792	nuclease activity
GIS01_01865	COG3107	peptidoglycan biosynthetic process
GIS01_01870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GIS01_01895	COG1987	bacterial-type flagellum assembly
GIS01_01915	COG2204	response regulator
GIS01_01920	COG1677	Flagellar hook-basal body complex protein FliE
GIS01_01930	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_01965	COG1815	bacterial-type flagellum-dependent cell motility
GIS01_01970	COG1558	bacterial-type flagellum-dependent cell motility
GIS01_01975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GIS01_01980	COG1749	Flagellar hook protein flgE
GIS01_01985	COG4787	bacterial-type flagellum-dependent cell motility
GIS01_01990	COG4786	Flagellar basal body rod
GIS01_01995	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GIS01_02000	COG1706	bacterial-type flagellum-dependent cell motility
GIS01_02015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_02025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_02030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GIS01_02055	COG1191	sigma factor activity
GIS01_02060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_02075	COG1388	LysM domain
GIS01_02075	COG0741	lytic transglycosylase activity
GIS01_02080	COG2001	Belongs to the MraZ family
GIS01_02085	COG0275	rRNA processing
GIS01_02090	COG3116	cell division
GIS01_02095	COG0768	penicillin binding
GIS01_02105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GIS01_02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GIS01_02115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GIS01_02120	COG0772	Belongs to the SEDS family
GIS01_02125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GIS01_02130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GIS01_02140	COG0849	cell division
GIS01_02145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GIS01_02150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GIS01_02160	COG0653	protein targeting
GIS01_02165	COG0494	nUDIX hydrolase
GIS01_02170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GIS01_02175	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GIS01_02185	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GIS01_02190	COG1459	type II secretion system
GIS01_02195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_02220	COG2186	Transcriptional regulator
GIS01_02225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GIS01_02230	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIS01_02235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GIS01_02245	COG0840	transmembrane signaling receptor activity
GIS01_02250	COG1752	Esterase of the alpha-beta hydrolase superfamily
GIS01_02255	COG1049	propionate catabolic process, 2-methylcitrate cycle
GIS01_02260	COG2200	EAL domain
GIS01_02270	COG0523	cobalamin synthesis protein
GIS01_02275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_02290	COG0477	Major facilitator Superfamily
GIS01_02305	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GIS01_02310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GIS01_02340	COG3422	double-strand break repair
GIS01_02385	COG2314	TM2 domain
GIS01_02435	COG0165	Argininosuccinate lyase
GIS01_02440	COG0137	argininosuccinate synthase activity
GIS01_02450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GIS01_02455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GIS01_02465	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GIS01_02475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GIS01_02485	COG0583	DNA-binding transcription factor activity
GIS01_02490	COG1380	Effector of murein hydrolase LrgA
GIS01_02495	COG1346	cytolysis
GIS01_02505	COG4667	esterase of the alpha-beta hydrolase superfamily
GIS01_02510	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GIS01_02515	COG1546	Belongs to the CinA family
GIS01_02520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GIS01_02530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GIS01_02535	COG0527	aspartate kinase activity
GIS01_02540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GIS01_02575	COG1686	Belongs to the peptidase S11 family
GIS01_02580	COG0586	Pfam SNARE associated Golgi protein
GIS01_02585	COG1253	flavin adenine dinucleotide binding
GIS01_02590	COG0252	asparaginase activity
GIS01_02610	COG1263	PTS System
GIS01_02610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_02615	COG0366	Alpha amylase catalytic
GIS01_02620	COG0110	maltose O-acetyltransferase activity
GIS01_02635	COG0564	pseudouridine synthase activity
GIS01_02640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIS01_02670	COG2926	Belongs to the UPF0265 family
GIS01_02680	COG0561	phosphatase activity
GIS01_02690	COG1546	Belongs to the CinA family
GIS01_02690	COG1058	Belongs to the CinA family
GIS01_02700	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GIS01_02710	COG1522	sequence-specific DNA binding
GIS01_02715	COG1368	sulfuric ester hydrolase activity
GIS01_02750	COG4221	oxidoreductase activity
GIS01_02765	COG1979	alcohol dehydrogenase
GIS01_02770	COG1803	Methylglyoxal synthase
GIS01_02795	COG1444	tRNA N-acetyltransferase activity
GIS01_02800	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_02805	COG0784	Response regulator, receiver
GIS01_02805	COG0835	chemotaxis
GIS01_02815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GIS01_02820	COG2949	membrane
GIS01_02825	COG3291	Pkd domain containing protein
GIS01_02835	COG3539	Fimbrial protein
GIS01_02845	COG3188	usher protein
GIS01_02850	COG3121	Chaperone
GIS01_02855	COG3539	Fimbrial protein
GIS01_02870	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_02875	COG1441	menaquinone biosynthetic process
GIS01_02880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GIS01_02885	COG0596	Alpha beta hydrolase
GIS01_02890	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GIS01_02895	COG1169	isochorismate synthase
GIS01_02900	COG1575	Belongs to the MenA family. Type 1 subfamily
GIS01_02925	COG0513	Belongs to the DEAD box helicase family
GIS01_02930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_02935	COG1988	membrane-bound metal-dependent
GIS01_02940	COG1671	Belongs to the UPF0178 family
GIS01_02960	COG0484	heat shock protein binding
GIS01_02970	COG3722	fumarate hydratase activity
GIS01_02975	COG0246	Mannitol dehydrogenase
GIS01_02980	COG2213	PTS system mannitol-specific
GIS01_02980	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_02985	COG1560	Kdo2-lipid A biosynthetic process
GIS01_02990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GIS01_02990	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GIS01_02995	COG1538	Outer membrane efflux protein
GIS01_03000	COG0494	nUDIX hydrolase
GIS01_03005	COG3151	Protein conserved in bacteria
GIS01_03015	COG3150	esterase
GIS01_03020	COG0187	DNA topoisomerase II activity
GIS01_03030	COG3104	oligopeptide transport
GIS01_03060	COG2084	Dehydrogenase
GIS01_03065	COG0583	DNA-binding transcription factor activity
GIS01_03070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_03090	COG0204	Acyl-transferase
GIS01_03095	COG1842	Phage shock protein A
GIS01_03110	COG2827	Endonuclease containing a URI domain
GIS01_03125	COG1573	uracil-dna glycosylase
GIS01_03130	COG0697	spore germination
GIS01_03135	COG0583	DNA-binding transcription factor activity
GIS01_03140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GIS01_03145	COG1121	(ABC) transporter
GIS01_03150	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GIS01_03170	COG0739	heme binding
GIS01_03180	COG3068	Protein conserved in bacteria
GIS01_03200	COG0617	tRNA 3'-terminal CCA addition
GIS01_03205	COG1194	a g-specific adenine glycosylase
GIS01_03210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GIS01_03220	COG3111	PFAM Bacterial OB fold (BOF) protein
GIS01_03225	COG3240	lipase activity
GIS01_03235	COG3706	GGDEF domain
GIS01_03240	COG0557	exoribonuclease II activity
GIS01_03260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GIS01_03270	COG2153	protein acetylation
GIS01_03275	COG0513	Belongs to the DEAD box helicase family
GIS01_03280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GIS01_03305	COG0735	belongs to the Fur family
GIS01_03370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GIS01_03375	COG3385	transposase activity
GIS01_03380	COG1022	Amp-dependent synthetase and ligase
GIS01_03390	COG0456	acetyltransferase
GIS01_03405	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GIS01_03410	COG3706	GGDEF domain
GIS01_03410	COG0745	RESPONSE REGULATOR receiver
GIS01_03415	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_03430	COG0477	Major facilitator Superfamily
GIS01_03435	COG0583	DNA-binding transcription factor activity
GIS01_03445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_03450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_03460	COG0673	inositol 2-dehydrogenase activity
GIS01_03470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GIS01_03475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GIS01_03480	COG3036	rescue of stalled ribosome
GIS01_03490	COG0138	bifunctional purine biosynthesis protein purh
GIS01_03495	COG0151	Belongs to the GarS family
GIS01_03515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GIS01_03520	COG0358	DNA primase activity
GIS01_03525	COG1610	YqeY-like protein
GIS01_03530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GIS01_03535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GIS01_03540	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GIS01_03545	COG1027	Aspartate ammonia-lyase
GIS01_03550	COG3030	protein affecting phage T7 exclusion by the F plasmid
GIS01_03560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GIS01_03565	COG0459	protein refolding
GIS01_03615	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GIS01_03620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GIS01_03625	COG1178	ABC-type Fe3 transport system permease component
GIS01_03630	COG4143	(ABC) transporter
GIS01_03645	COG0066	3-isopropylmalate dehydratase activity
GIS01_03650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GIS01_03655	COG0473	3-isopropylmalate dehydrogenase activity
GIS01_03660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GIS01_03685	COG0028	Belongs to the TPP enzyme family
GIS01_03690	COG0440	acetolactate synthase activity
GIS01_03705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GIS01_03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_03750	COG0745	RESPONSE REGULATOR receiver
GIS01_03755	COG3104	oligopeptide transport
GIS01_03760	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GIS01_03765	COG1555	photosystem II stabilization
GIS01_03770	COG0280	phosphate acetyltransferase
GIS01_03770	COG0857	belongs to the CobB CobQ family
GIS01_03775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GIS01_03780	COG3092	negative regulation of chromosome organization
GIS01_03785	COG3013	Belongs to the UPF0304 family
GIS01_03790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GIS01_03795	COG2716	regulation of RNA biosynthetic process
GIS01_03800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIS01_03805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GIS01_03810	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GIS01_03845	COG0784	Response regulator, receiver
GIS01_03845	COG5002	protein histidine kinase activity
GIS01_03845	COG2198	Histidine kinase
GIS01_03870	COG0840	transmembrane signaling receptor activity
GIS01_03880	COG1464	Belongs to the NlpA lipoprotein family
GIS01_03885	COG2011	ABC-type metal ion transport system permease component
GIS01_03890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GIS01_03910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GIS01_03910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GIS01_03915	COG0802	atpase or kinase
GIS01_03925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GIS01_03930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GIS01_03935	COG1923	regulation of RNA biosynthetic process
GIS01_03940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GIS01_03945	COG0330	HflC and HflK could
GIS01_03950	COG0330	HflC and HflK could
GIS01_03955	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GIS01_03960	COG0142	geranyltranstransferase activity
GIS01_03965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GIS01_03970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GIS01_03975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GIS01_03990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GIS01_04010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GIS01_04020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GIS01_04025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GIS01_04030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_04035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GIS01_04040	COG3178	'Phosphotransferase
GIS01_04045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GIS01_04050	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GIS01_04055	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_04065	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GIS01_04085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GIS01_04100	COG4628	conserved protein (DUF2132)
GIS01_04105	COG0688	phosphatidylethanolamine metabolic process
GIS01_04115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GIS01_04145	COG1278	Cold shock
GIS01_04155	COG0840	transmembrane signaling receptor activity
GIS01_04160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_04165	COG2252	PERMEase
GIS01_04175	COG0488	(ABC) transporter
GIS01_04190	COG0741	lytic transglycosylase activity
GIS01_04200	COG3416	Protein conserved in bacteria
GIS01_04220	COG4608	Belongs to the ABC transporter superfamily
GIS01_04225	COG0444	Belongs to the ABC transporter superfamily
GIS01_04235	COG4239	(ABC) transporter, permease
GIS01_04240	COG4174	ABC transporter (Permease)
GIS01_04245	COG4206	TonB-dependent receptor
GIS01_04255	COG0811	peptide transport
GIS01_04260	COG0811	peptide transport
GIS01_04265	COG0848	biopolymer transport protein
GIS01_04285	COG0616	signal peptide processing
GIS01_04290	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_04290	COG1902	pentaerythritol trinitrate reductase activity
GIS01_04295	COG0778	Nitroreductase
GIS01_04300	COG0110	maltose O-acetyltransferase activity
GIS01_04310	COG2264	protein methyltransferase activity
GIS01_04315	COG0604	alcohol dehydrogenase
GIS01_04320	COG0583	DNA-binding transcription factor activity
GIS01_04325	COG2190	(PTS) system
GIS01_04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_04325	COG1263	PTS System
GIS01_04330	COG4145	pantothenate transmembrane transporter activity
GIS01_04340	COG0439	Biotin carboxylase
GIS01_04345	COG0511	ligase activity, forming carbon-carbon bonds
GIS01_04350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GIS01_04355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIS01_04375	COG3381	protein complex oligomerization
GIS01_04385	COG3005	denitrification pathway
GIS01_04390	COG0745	RESPONSE REGULATOR receiver
GIS01_04400	COG1879	ABC-type sugar transport system periplasmic component
GIS01_04405	COG2198	Histidine kinase
GIS01_04405	COG0784	Response regulator, receiver
GIS01_04405	COG2205	protein histidine kinase activity
GIS01_04415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GIS01_04420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GIS01_04425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GIS01_04425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GIS01_04440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GIS01_04445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_04450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GIS01_04455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GIS01_04480	COG2900	Belongs to the SlyX family
GIS01_04490	COG0545	Peptidyl-prolyl cis-trans isomerase
GIS01_04495	COG2204	response regulator
GIS01_04515	COG0737	Belongs to the 5'-nucleotidase family
GIS01_04520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GIS01_04525	COG0142	geranyltranstransferase activity
GIS01_04530	COG1722	exodeoxyribonuclease VII activity
GIS01_04535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_04540	COG1360	Flagellar Motor Protein
GIS01_04545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_04555	COG1534	Rna-binding protein
GIS01_04560	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GIS01_04565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIS01_04570	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GIS01_04575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GIS01_04580	COG0149	triose-phosphate isomerase activity
GIS01_04585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GIS01_04600	COG0779	Required for maturation of 30S ribosomal subunits
GIS01_04605	COG0195	Participates in both transcription termination and antitermination
GIS01_04610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GIS01_04615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GIS01_04620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GIS01_04625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GIS01_04630	COG1185	polyribonucleotide nucleotidyltransferase activity
GIS01_04635	COG2201	protein-glutamate methylesterase activity
GIS01_04640	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GIS01_04650	COG0840	transmembrane signaling receptor activity
GIS01_04655	COG0835	chemotaxis
GIS01_04665	COG0643	Histidine kinase
GIS01_04665	COG2198	Histidine kinase
GIS01_04695	COG1280	lysine exporter protein (LysE YggA)
GIS01_04700	COG0826	peptidase U32
GIS01_04705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GIS01_04745	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GIS01_04770	COG0300	oxidoreductase activity
GIS01_04780	COG0840	transmembrane signaling receptor activity
GIS01_04825	COG2226	methyltransferase
GIS01_04865	COG1116	anion transmembrane transporter activity
GIS01_04885	COG4771	TonB-dependent receptor
GIS01_04910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GIS01_04915	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_04950	COG0720	synthase
GIS01_04975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GIS01_04980	COG0602	queuosine metabolic process
GIS01_04990	COG2003	Belongs to the UPF0758 family
GIS01_05035	COG5377	YqaJ viral recombinase family
GIS01_05065	COG0077	Prephenate dehydratase
GIS01_05065	COG1605	Chorismate mutase
GIS01_05095	COG3272	Protein of unknown function (DUF1722)
GIS01_05100	COG0789	Transcriptional regulator
GIS01_05105	COG0415	Belongs to the DNA photolyase family
GIS01_05115	COG0300	oxidoreductase activity
GIS01_05130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GIS01_05160	COG1477	protein flavinylation
GIS01_05165	COG2871	sodium ion transport
GIS01_05170	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_05175	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_05185	COG1805	sodium ion transport
GIS01_05190	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_05195	COG0271	Belongs to the BolA IbaG family
GIS01_05200	COG2813	Specifically methylates the guanine in position
GIS01_05210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GIS01_05215	COG2211	Major facilitator Superfamily
GIS01_05220	COG3248	Nucleoside-binding outer membrane protein
GIS01_05225	COG1666	GTP binding
GIS01_05230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GIS01_05245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GIS01_05250	COG0840	transmembrane signaling receptor activity
GIS01_05255	COG0583	DNA-binding transcription factor activity
GIS01_05265	COG2363	Small membrane protein
GIS01_05270	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GIS01_05280	COG0473	3-isopropylmalate dehydrogenase activity
GIS01_05285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_05290	COG1611	Belongs to the LOG family
GIS01_05295	COG3706	GGDEF domain
GIS01_05305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GIS01_05305	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GIS01_05315	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GIS01_05340	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_05365	COG3646	Phage regulatory protein
GIS01_05365	COG3645	SOS response
GIS01_05390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_05420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GIS01_05445	COG3098	single-species biofilm formation
GIS01_05450	COG0564	pseudouridine synthase activity
GIS01_05460	COG4580	involved in the transport of maltose and maltodextrins
GIS01_05470	COG1263	PTS System
GIS01_05470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_05480	COG2171	N-acyltransferase activity
GIS01_05485	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GIS01_05490	COG0024	Methionine aminopeptidase
GIS01_05495	COG0052	Belongs to the universal ribosomal protein uS2 family
GIS01_05500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GIS01_05505	COG0528	UMP kinase activity
GIS01_05510	COG0233	cytoplasmic translational termination
GIS01_05520	COG0575	Belongs to the CDS family
GIS01_05525	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GIS01_05530	COG0750	zinc metalloprotease
GIS01_05545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_05550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GIS01_05555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_05560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_05565	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GIS01_05575	COG0825	malonyl-CoA metabolic process
GIS01_05585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GIS01_05590	COG1115	amino acid carrier protein
GIS01_05605	COG0714	Associated with various cellular activities
GIS01_05620	COG0583	DNA-binding transcription factor activity
GIS01_05625	COG3104	oligopeptide transport
GIS01_05630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GIS01_05635	COG1678	Uncharacterized ACR, COG1678
GIS01_05640	COG0189	ligase activity
GIS01_05645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GIS01_05655	COG3091	SprT-like family
GIS01_05665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GIS01_05680	COG0583	DNA-binding transcription factor activity
GIS01_05695	COG0251	oxidation-reduction process
GIS01_05710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GIS01_05715	COG0739	heme binding
GIS01_05720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GIS01_05750	COG0814	amino acid
GIS01_05770	COG0531	amino acid
GIS01_05775	COG3710	Transcriptional regulator
GIS01_05780	COG0531	amino acid
GIS01_05785	COG1982	Orn Lys Arg decarboxylase major
GIS01_05790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GIS01_05800	COG3590	peptidase
GIS01_05810	COG2199	diguanylate cyclase activity
GIS01_05810	COG2203	Gaf domain
GIS01_05845	COG0366	Alpha amylase catalytic
GIS01_05860	COG0463	Glycosyl transferase, family 2
GIS01_05875	COG2989	Protein conserved in bacteria
GIS01_05880	COG3108	Peptidase M15
GIS01_05890	COG2860	membrane
GIS01_05900	COG1196	nuclear chromosome segregation
GIS01_05905	COG3115	cell septum assembly
GIS01_05910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GIS01_05920	COG1328	CTP reductase activity
GIS01_05925	COG0602	queuosine metabolic process
GIS01_05955	COG1566	PFAM secretion protein HlyD family protein
GIS01_05960	COG1846	Transcriptional regulator
GIS01_05970	COG0281	malic enzyme
GIS01_05975	COG3290	protein histidine kinase activity
GIS01_05985	COG0697	spore germination
GIS01_05995	COG3706	GGDEF domain
GIS01_06000	COG0346	lactoylglutathione lyase activity
GIS01_06005	COG0745	RESPONSE REGULATOR receiver
GIS01_06010	COG5002	protein histidine kinase activity
GIS01_06020	COG4783	chaperone-mediated protein folding
GIS01_06035	COG3142	Participates in the control of copper homeostasis
GIS01_06040	COG0545	Peptidyl-prolyl cis-trans isomerase
GIS01_06055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GIS01_06065	COG0678	peroxiredoxin activity
GIS01_06075	COG0019	diaminopimelate decarboxylase activity
GIS01_06080	COG1115	amino acid carrier protein
GIS01_06085	COG0095	Lipoate-protein ligase
GIS01_06090	COG2233	PERMEase
GIS01_06095	COG3706	GGDEF domain
GIS01_06105	COG0534	Mate efflux family protein
GIS01_06115	COG0281	malic enzyme
GIS01_06145	COG0531	amino acid
GIS01_06150	COG1752	Esterase of the alpha-beta hydrolase superfamily
GIS01_06155	COG3706	GGDEF domain
GIS01_06160	COG1566	PFAM secretion protein HlyD family protein
GIS01_06170	COG1032	radical SAM domain protein
GIS01_06215	COG0583	DNA-binding transcription factor activity
GIS01_06220	COG0673	inositol 2-dehydrogenase activity
GIS01_06225	COG2920	part of a sulfur-relay system
GIS01_06230	COG1289	transmembrane transporter activity
GIS01_06235	COG0670	Belongs to the BI1 family
GIS01_06250	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GIS01_06260	COG3156	type II secretion system protein K
GIS01_06265	COG4795	General secretion pathway protein
GIS01_06270	COG2165	general secretion pathway protein
GIS01_06280	COG2165	general secretion pathway protein
GIS01_06285	COG1459	type II secretion system
GIS01_06290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_06300	COG3031	protein transport across the cell outer membrane
GIS01_06310	COG3267	Type II secretory pathway component ExeA
GIS01_06310	COG3409	Peptidoglycan-binding domain 1 protein
GIS01_06315	COG2770	Histidine kinase
GIS01_06315	COG3437	response regulator, receiver
GIS01_06330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GIS01_06335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GIS01_06340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_06350	COG2190	(PTS) system
GIS01_06355	COG3706	GGDEF domain
GIS01_06360	COG3590	peptidase
GIS01_06370	COG3264	Mechanosensitive ion channel
GIS01_06370	COG1196	nuclear chromosome segregation
GIS01_06375	COG0469	pyruvate kinase activity
GIS01_06385	COG3384	dioxygenase
GIS01_06390	COG0419	ATPase involved in DNA repair
GIS01_06395	COG0420	3'-5' exonuclease activity
GIS01_06405	COG2974	May be involved in recombination
GIS01_06410	COG0405	Gamma-glutamyltransferase
GIS01_06420	COG1283	sodium-dependent phosphate transmembrane transporter activity
GIS01_06430	COG0531	amino acid
GIS01_06440	COG0531	amino acid
GIS01_06455	COG1917	Cupin 2, conserved barrel domain protein
GIS01_06455	COG1396	sequence-specific DNA binding
GIS01_06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_06480	COG0745	RESPONSE REGULATOR receiver
GIS01_06490	COG3038	cytochrome b561
GIS01_06495	COG1720	tRNA m6t6A37 methyltransferase activity
GIS01_06515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GIS01_06520	COG4988	ABC transporter
GIS01_06535	COG0745	RESPONSE REGULATOR receiver
GIS01_06545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GIS01_06575	COG0798	PFAM Bile acid sodium symporter
GIS01_06585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_06605	COG1988	membrane-bound metal-dependent
GIS01_06620	COG0159	tryptophan synthase activity
GIS01_06625	COG0133	tryptophan synthase activity
GIS01_06630	COG0135	phosphoribosylanthranilate isomerase activity
GIS01_06630	COG0134	indole-3-glycerol-phosphate synthase activity
GIS01_06635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GIS01_06640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GIS01_06640	COG0512	Glutamine amidotransferase of anthranilate synthase
GIS01_06645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GIS01_06655	COG0009	L-threonylcarbamoyladenylate synthase
GIS01_06665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GIS01_06680	COG1946	Acyl-CoA thioesterase
GIS01_06685	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GIS01_06690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GIS01_06705	COG0083	homoserine kinase activity
GIS01_06710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GIS01_06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIS01_06750	COG1342	Belongs to the UPF0251 family
GIS01_06765	COG1309	transcriptional regulator
GIS01_06770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_06775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_06785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GIS01_06790	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GIS01_06800	COG1091	dTDP-4-dehydrorhamnose reductase activity
GIS01_06820	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_06825	COG2030	dehydratase
GIS01_06855	COG1216	Glycosyl transferase, family 2
GIS01_06860	COG0482	sulfurtransferase activity
GIS01_06865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GIS01_06875	COG1086	Polysaccharide biosynthesis protein
GIS01_06900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GIS01_06920	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GIS01_06930	COG0489	protein tyrosine kinase activity
GIS01_06930	COG3206	protein involved in exopolysaccharide biosynthesis
GIS01_06950	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_06965	COG1538	Outer membrane efflux protein
GIS01_06970	COG0577	efflux transmembrane transporter activity
GIS01_06970	COG1136	(ABC) transporter
GIS01_06975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_06980	COG1227	inorganic diphosphatase activity
GIS01_06985	COG0497	DNA recombination
GIS01_06990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GIS01_06995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GIS01_07000	COG0443	Heat shock 70 kDa protein
GIS01_07005	COG0484	heat shock protein binding
GIS01_07035	COG1285	pathogenesis
GIS01_07065	COG2391	methyltransferase activity
GIS01_07080	COG1566	PFAM secretion protein HlyD family protein
GIS01_07085	COG1136	(ABC) transporter
GIS01_07085	COG0577	efflux transmembrane transporter activity
GIS01_07090	COG0577	efflux transmembrane transporter activity
GIS01_07090	COG1136	(ABC) transporter
GIS01_07095	COG1136	(ABC) transporter
GIS01_07095	COG0577	efflux transmembrane transporter activity
GIS01_07105	COG0095	Lipoate-protein ligase
GIS01_07115	COG0702	epimerase
GIS01_07120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_07125	COG1454	alcohol dehydrogenase
GIS01_07135	COG0564	pseudouridine synthase activity
GIS01_07170	COG1280	lysine exporter protein (LysE YggA)
GIS01_07185	COG3263	regulation of cellular component size
GIS01_07195	COG1876	peptidase activity
GIS01_07200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIS01_07205	COG1393	Belongs to the ArsC family
GIS01_07215	COG3069	C4-dicarboxylate transmembrane transporter activity
GIS01_07220	COG1473	amidohydrolase
GIS01_07230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GIS01_07240	COG0017	Asparaginyl-tRNA synthetase
GIS01_07255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GIS01_07260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GIS01_07265	COG0156	8-amino-7-oxononanoate synthase activity
GIS01_07270	COG2226	methyltransferase
GIS01_07270	COG1073	alpha beta
GIS01_07275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GIS01_07280	COG0501	Belongs to the peptidase M48B family
GIS01_07290	COG3217	Mosc domain protein beta barrel domain protein
GIS01_07290	COG0633	Ferredoxin
GIS01_07290	COG0633	Ferredoxin
GIS01_07290	COG3217	Mosc domain protein beta barrel domain protein
GIS01_07305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GIS01_07305	COG1013	pyruvate-flavodoxin oxidoreductase activity
GIS01_07305	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GIS01_07305	COG0674	pyruvate-flavodoxin oxidoreductase activity
GIS01_07315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GIS01_07320	COG1607	acyl-coa hydrolase
GIS01_07330	COG3021	interspecies interaction between organisms
GIS01_07335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GIS01_07340	COG2027	D-alanyl-D-alanine carboxypeptidase
GIS01_07345	COG1061	Type III restriction enzyme res subunit
GIS01_07350	COG1566	PFAM secretion protein HlyD family protein
GIS01_07360	COG1966	Carbon starvation protein
GIS01_07365	COG3279	Response regulator of the LytR AlgR family
GIS01_07370	COG3275	phosphorelay sensor kinase activity
GIS01_07375	COG2199	diguanylate cyclase activity
GIS01_07375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_07385	COG1846	Transcriptional regulator
GIS01_07385	COG1940	carbohydrate kinase activity
GIS01_07390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GIS01_07395	COG0363	glucosamine-6-phosphate deaminase activity
GIS01_07400	COG1263	PTS System
GIS01_07400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_07400	COG2190	(PTS) system
GIS01_07410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_07415	COG0735	belongs to the Fur family
GIS01_07425	COG0716	FMN binding
GIS01_07440	COG0596	Alpha beta hydrolase
GIS01_07445	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GIS01_07450	COG0033	Phosphoglucomutase
GIS01_07460	COG1846	Transcriptional regulator
GIS01_07465	COG2951	lytic endotransglycosylase activity
GIS01_07470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GIS01_07475	COG4136	ATPase activity
GIS01_07485	COG4134	Bacterial extracellular solute-binding protein
GIS01_07495	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GIS01_07505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_07515	COG0729	surface antigen
GIS01_07520	COG2911	Protein conserved in bacteria
GIS01_07540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GIS01_07550	COG0741	lytic transglycosylase activity
GIS01_07560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_07565	COG4771	TonB-dependent receptor
GIS01_07570	COG1169	isochorismate synthase
GIS01_07575	COG1021	2,3-dihydroxybenzoate-AMP ligase
GIS01_07580	COG3433	isochorismatase activity
GIS01_07580	COG1535	isochorismatase
GIS01_07585	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_07590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GIS01_07590	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GIS01_07615	COG1278	Cold shock
GIS01_07640	COG4166	transmembrane transport
GIS01_07645	COG1349	DNA-binding transcription factor activity
GIS01_07655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_07660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GIS01_07670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_07675	COG1187	pseudouridine synthase activity
GIS01_07685	COG4166	transmembrane transport
GIS01_07690	COG0622	Phosphoesterase
GIS01_07705	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GIS01_07710	COG0835	chemotaxis
GIS01_07710	COG0784	Response regulator, receiver
GIS01_07715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GIS01_07720	COG1815	bacterial-type flagellum-dependent cell motility
GIS01_07725	COG1558	bacterial-type flagellum-dependent cell motility
GIS01_07730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GIS01_07740	COG4787	bacterial-type flagellum-dependent cell motility
GIS01_07745	COG4786	Flagellar basal body rod
GIS01_07750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GIS01_07755	COG1706	bacterial-type flagellum-dependent cell motility
GIS01_07770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_07775	COG2239	Acts as a magnesium transporter
GIS01_07780	COG0248	Ppx GppA phosphatase
GIS01_07785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GIS01_07790	COG2716	regulation of RNA biosynthetic process
GIS01_07800	COG2204	response regulator
GIS01_07805	COG3852	Histidine kinase
GIS01_07810	COG2204	response regulator
GIS01_07815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GIS01_07820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GIS01_07825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GIS01_07830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GIS01_07850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GIS01_07860	COG0590	tRNA wobble adenosine to inosine editing
GIS01_07865	COG0573	inorganic phosphate transmembrane transporter activity
GIS01_07870	COG0581	inorganic phosphate transmembrane transporter activity
GIS01_07880	COG0704	Plays a role in the regulation of phosphate uptake
GIS01_07885	COG1253	flavin adenine dinucleotide binding
GIS01_07900	COG0531	amino acid
GIS01_07915	COG1126	abc transporter atp-binding protein
GIS01_07920	COG0765	amino acid transport
GIS01_07925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_07930	COG3706	GGDEF domain
GIS01_07935	COG2271	Major facilitator Superfamily
GIS01_07945	COG2197	response regulator
GIS01_07950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GIS01_07970	COG1785	Belongs to the alkaline phosphatase family
GIS01_07975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GIS01_07980	COG0123	including yeast histone deacetylase and acetoin utilization protein
GIS01_07990	COG1199	ATP-dependent helicase activity
GIS01_08000	COG0287	Prephenate dehydrogenase
GIS01_08000	COG1605	Chorismate mutase
GIS01_08005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_08015	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_08020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_08055	COG0537	adenosine 5'-monophosphoramidase activity
GIS01_08070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GIS01_08085	COG1301	dicarboxylic acid transport
GIS01_08100	COG2354	Protein conserved in bacteria
GIS01_08110	COG2233	PERMEase
GIS01_08120	COG1252	NADH dehydrogenase
GIS01_08130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_08135	COG3300	MHYT domain
GIS01_08135	COG5001	Diguanylate cyclase
GIS01_08140	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_08150	COG2373	Large extracellular alpha-helical protein
GIS01_08155	COG4953	penicillin-binding protein 1C
GIS01_08185	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_08225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_08255	COG0301	tRNA thio-modification
GIS01_08275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_08280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_08285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GIS01_08290	COG1334	flagellar protein FlaG
GIS01_08315	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_08320	COG1083	cytidylyl-transferase
GIS01_08325	COG0673	inositol 2-dehydrogenase activity
GIS01_08335	COG2030	dehydratase
GIS01_08345	COG2089	acid synthase
GIS01_08350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GIS01_08355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GIS01_08380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GIS01_08395	COG0483	inositol monophosphate 1-phosphatase activity
GIS01_08405	COG0625	glutathione transferase activity
GIS01_08410	COG2814	Major facilitator Superfamily
GIS01_08415	COG0583	DNA-binding transcription factor activity
GIS01_08420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GIS01_08425	COG0243	molybdopterin cofactor binding
GIS01_08435	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GIS01_08445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_08450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_08460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GIS01_08465	COG0509	glycine decarboxylation via glycine cleavage system
GIS01_08470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIS01_08470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GIS01_08475	COG0840	transmembrane signaling receptor activity
GIS01_08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GIS01_08510	COG0574	Belongs to the PEP-utilizing enzyme family
GIS01_08510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIS01_08525	COG1464	Belongs to the NlpA lipoprotein family
GIS01_08530	COG3083	sulfuric ester hydrolase activity
GIS01_08535	COG3082	Protein of unknown function (DUF1414)
GIS01_08540	COG3081	Nucleoid-associated protein
GIS01_08550	COG1175	transmembrane transport
GIS01_08560	COG3842	ATPase activity
GIS01_08590	COG4783	chaperone-mediated protein folding
GIS01_08600	COG1393	Belongs to the ArsC family
GIS01_08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_08620	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GIS01_08625	COG2431	L-lysine efflux transmembrane transporter activity
GIS01_08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_08640	COG4215	(ABC) transporter
GIS01_08645	COG4160	amino acid transport
GIS01_08650	COG0564	pseudouridine synthase activity
GIS01_08665	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GIS01_08675	COG0625	glutathione transferase activity
GIS01_08685	COG0367	asparagine synthase
GIS01_08695	COG4651	solute:proton antiporter activity
GIS01_08695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GIS01_08700	COG0647	UMP catabolic process
GIS01_08705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIS01_08715	COG1902	pentaerythritol trinitrate reductase activity
GIS01_08720	COG1253	flavin adenine dinucleotide binding
GIS01_08730	COG0247	lactate metabolic process
GIS01_08730	COG0277	FAD linked oxidase domain protein
GIS01_08740	COG2050	protein possibly involved in aromatic compounds catabolism
GIS01_08750	COG2056	Na+-H+ antiporter family
GIS01_08755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_08760	COG0671	phosphoesterase, PA-phosphatase related
GIS01_08765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIS01_08770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GIS01_08780	COG0101	tRNA pseudouridine synthase activity
GIS01_08785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GIS01_08790	COG0285	dihydrofolate synthase activity
GIS01_08795	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GIS01_08800	COG0393	Putative heavy-metal-binding
GIS01_08810	COG1648	precorrin-2 dehydrogenase activity
GIS01_08810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_08815	COG2221	Nitrite and sulphite reductase 4Fe-4S
GIS01_08830	COG4667	esterase of the alpha-beta hydrolase superfamily
GIS01_08835	COG1619	proteins homologs of microcin C7 resistance protein MccF
GIS01_08840	COG1368	sulfuric ester hydrolase activity
GIS01_08850	COG0527	aspartate kinase activity
GIS01_08855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GIS01_08855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GIS01_08860	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GIS01_08930	COG0596	Alpha beta hydrolase
GIS01_08960	COG1136	(ABC) transporter
GIS01_08975	COG2814	Major facilitator Superfamily
GIS01_08995	COG0672	)-iron permease
GIS01_09035	COG0659	secondary active sulfate transmembrane transporter activity
GIS01_09065	COG1629	transport
GIS01_09065	COG4771	TonB-dependent receptor
GIS01_09085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GIS01_09090	COG0326	Molecular chaperone. Has ATPase activity
GIS01_09095	COG4172	Belongs to the ABC transporter superfamily
GIS01_09100	COG4172	Belongs to the ABC transporter superfamily
GIS01_09105	COG4171	peptide transport system, permease
GIS01_09110	COG4168	peptide transport system, permease
GIS01_09120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GIS01_09125	COG1842	Phage shock protein A
GIS01_09140	COG3106	COG3106 Predicted ATPase
GIS01_09145	COG3768	UPF0283 membrane protein
GIS01_09150	COG0583	DNA-binding transcription factor activity
GIS01_09155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GIS01_09160	COG3842	ATPase activity
GIS01_09165	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_09170	COG1177	transmembrane transport
GIS01_09175	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_09185	COG2154	pterin-4-alpha-carbinolamine dehydratase
GIS01_09205	COG2199	diguanylate cyclase activity
GIS01_09210	COG2885	chlorophyll binding
GIS01_09215	COG0861	Integral membrane protein TerC family
GIS01_09245	COG2910	NAD(P)H-binding
GIS01_09250	COG0583	DNA-binding transcription factor activity
GIS01_09255	COG0583	DNA-binding transcription factor activity
GIS01_09270	COG1335	isochorismatase
GIS01_09280	COG0583	DNA-binding transcription factor activity
GIS01_09285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GIS01_09295	COG0583	DNA-binding transcription factor activity
GIS01_09300	COG2723	6-phospho-beta-galactosidase activity
GIS01_09305	COG1944	ATP diphosphatase activity
GIS01_09310	COG2116	formate transmembrane transporter activity
GIS01_09315	COG1882	Formate acetyltransferase
GIS01_09325	COG4166	transmembrane transport
GIS01_09330	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GIS01_09335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GIS01_09345	COG4591	ABC-type transport system involved in lipoprotein release permease component
GIS01_09350	COG1136	(ABC) transporter
GIS01_09355	COG4591	ABC-type transport system involved in lipoprotein release permease component
GIS01_09360	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GIS01_09370	COG0544	peptidyl-prolyl cis-trans isomerase activity
GIS01_09375	COG0740	serine-type endopeptidase activity
GIS01_09380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GIS01_09385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GIS01_09390	COG0776	regulation of translation
GIS01_09395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GIS01_09400	COG0488	(ABC) transporter
GIS01_09405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIS01_09410	COG3162	membrane
GIS01_09425	COG1024	Enoyl-CoA hydratase
GIS01_09430	COG4695	Portal protein
GIS01_09475	COG1115	amino acid carrier protein
GIS01_09490	COG1584	GPR1 FUN34 yaaH family protein
GIS01_09520	COG1024	Enoyl-CoA hydratase
GIS01_09525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GIS01_09530	COG1960	acyl-CoA dehydrogenase activity
GIS01_09535	COG1960	acyl-CoA dehydrogenase activity
GIS01_09540	COG1024	Enoyl-CoA hydratase
GIS01_09545	COG1024	Enoyl-CoA hydratase
GIS01_09555	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_09565	COG0730	response to heat
GIS01_09590	COG2826	transposase and inactivated derivatives, IS30 family
GIS01_09600	COG5001	Diguanylate cyclase
GIS01_09600	COG5002	protein histidine kinase activity
GIS01_09620	COG2003	Belongs to the UPF0758 family
GIS01_09635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GIS01_09685	COG3437	response regulator, receiver
GIS01_09685	COG3850	Histidine kinase
GIS01_09685	COG2205	protein histidine kinase activity
GIS01_09685	COG4999	Histidine kinase
GIS01_09725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GIS01_09730	COG1215	transferase activity, transferring glycosyl groups
GIS01_09735	COG0438	transferase activity, transferring glycosyl groups
GIS01_09780	COG0438	transferase activity, transferring glycosyl groups
GIS01_09800	COG0438	transferase activity, transferring glycosyl groups
GIS01_09805	COG0438	transferase activity, transferring glycosyl groups
GIS01_09810	COG2203	Gaf domain
GIS01_09810	COG5001	Diguanylate cyclase
GIS01_09810	COG4251	negative regulation of phosphorylation
GIS01_09810	COG3706	GGDEF domain
GIS01_09815	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_09820	COG3437	response regulator, receiver
GIS01_09825	COG3437	response regulator, receiver
GIS01_09825	COG3850	Histidine kinase
GIS01_09825	COG4999	Histidine kinase
GIS01_09825	COG2205	protein histidine kinase activity
GIS01_09830	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GIS01_09835	COG0437	4 iron, 4 sulfur cluster binding
GIS01_09840	COG5557	Pfam Polysulphide reductase, NrfD
GIS01_09845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GIS01_09850	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GIS01_09855	COG1773	rubredoxin
GIS01_09870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_09880	COG3842	ATPase activity
GIS01_09885	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GIS01_09890	COG0375	protein maturation
GIS01_09895	COG0309	Hydrogenase expression formation protein (HypE)
GIS01_09905	COG0298	carbon dioxide binding
GIS01_09910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GIS01_09920	COG1921	L-seryl-tRNASec selenium transferase activity
GIS01_09930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GIS01_09940	COG3260	NADH ubiquinone oxidoreductase 20
GIS01_09945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_09950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GIS01_09950	COG3261	NADH dehydrogenase
GIS01_09955	COG0650	Formate hydrogenlyase subunit 4
GIS01_09960	COG0651	ATP synthesis coupled electron transport
GIS01_09965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_09970	COG3158	transport of potassium into the cell
GIS01_09985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_10010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GIS01_10015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_10020	COG3046	protein related to deoxyribodipyrimidine photolyase
GIS01_10030	COG3033	Beta-eliminating lyase
GIS01_10035	COG0295	cytidine deaminase activity
GIS01_10040	COG1346	cytolysis
GIS01_10045	COG1380	Effector of murein hydrolase LrgA
GIS01_10050	COG3345	alpha-galactosidase
GIS01_10060	COG2925	Exonuclease
GIS01_10070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_10080	COG1643	Atp-dependent helicase
GIS01_10090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GIS01_10105	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GIS01_10110	COG2067	long-chain fatty acid transport protein
GIS01_10115	COG2067	long-chain fatty acid transport protein
GIS01_10125	COG1595	DNA-templated transcription, initiation
GIS01_10135	COG2304	oxidoreductase activity
GIS01_10155	COG0714	Associated with various cellular activities
GIS01_10160	COG0183	Belongs to the thiolase family
GIS01_10165	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIS01_10165	COG1024	Enoyl-CoA hydratase
GIS01_10170	COG2719	SpoVR family
GIS01_10175	COG2718	Belongs to the UPF0229 family
GIS01_10180	COG2766	serine protein kinase
GIS01_10185	COG0514	ATP-dependent DNA helicase (RecQ)
GIS01_10190	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GIS01_10200	COG0814	amino acid
GIS01_10205	COG0494	nUDIX hydrolase
GIS01_10220	COG2824	Alkylphosphonate utilization operon protein PhnA
GIS01_10235	COG0406	alpha-ribazole phosphatase activity
GIS01_10240	COG3706	GGDEF domain
GIS01_10245	COG2840	Smr protein MutS2
GIS01_10250	COG2890	protein-(glutamine-N5) methyltransferase activity
GIS01_10255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GIS01_10265	COG0513	Belongs to the DEAD box helicase family
GIS01_10275	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GIS01_10290	COG0814	amino acid
GIS01_10295	COG1609	Transcriptional regulator
GIS01_10300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_10300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_10305	COG1105	Belongs to the carbohydrate kinase PfkB family
GIS01_10310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GIS01_10310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_10310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_10315	COG3313	Fe-S protein
GIS01_10320	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GIS01_10325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_10330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIS01_10335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GIS01_10345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIS01_10355	COG0366	Alpha amylase catalytic
GIS01_10370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GIS01_10375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GIS01_10380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GIS01_10385	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GIS01_10390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GIS01_10395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_10395	COG0072	phenylalanine-tRNA ligase activity
GIS01_10400	COG0776	regulation of translation
GIS01_10405	COG0784	Response regulator, receiver
GIS01_10405	COG2205	protein histidine kinase activity
GIS01_10420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GIS01_10430	COG3300	MHYT domain
GIS01_10430	COG5001	Diguanylate cyclase
GIS01_10435	COG1609	Transcriptional regulator
GIS01_10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_10445	COG1879	ABC-type sugar transport system periplasmic component
GIS01_10450	COG1172	Belongs to the binding-protein-dependent transport system permease family
GIS01_10455	COG1129	ABC transporter
GIS01_10460	COG1869	D-ribose catabolic process
GIS01_10465	COG0625	glutathione transferase activity
GIS01_10475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GIS01_10480	COG1177	transmembrane transport
GIS01_10485	COG1176	ABC-type spermidine putrescine transport system, permease component I
GIS01_10505	COG0037	tRNA processing
GIS01_10510	COG0589	response to stress
GIS01_10515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_10530	COG2217	Heavy metal translocating P-type atpase
GIS01_10540	COG2010	Cytochrome c
GIS01_10555	COG3278	Belongs to the heme-copper respiratory oxidase family
GIS01_10565	COG1956	GAF domain-containing protein
GIS01_10570	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GIS01_10580	COG0308	aminopeptidase N
GIS01_10590	COG2902	Dehydrogenase
GIS01_10595	COG0167	dihydroorotate dehydrogenase activity
GIS01_10605	COG0254	rRNA binding
GIS01_10610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GIS01_10615	COG0116	Belongs to the methyltransferase superfamily
GIS01_10615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GIS01_10625	COG0488	(ABC) transporter
GIS01_10635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GIS01_10640	COG1067	ATP-dependent peptidase activity
GIS01_10670	COG3141	response to X-ray
GIS01_10675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GIS01_10680	COG4221	oxidoreductase activity
GIS01_10725	COG0372	Belongs to the citrate synthase family
GIS01_10730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GIS01_10740	COG2995	paraquat-inducible protein a
GIS01_10745	COG3008	intermembrane lipid transfer
GIS01_10750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GIS01_10750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_10765	COG0084	hydrolase, TatD family'
GIS01_10770	COG0470	DNA polymerase III
GIS01_10775	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GIS01_10780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GIS01_10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GIS01_10790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GIS01_10795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GIS01_10800	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_10810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GIS01_10815	COG0416	fatty acid biosynthetic process
GIS01_10820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GIS01_10825	COG1399	metal-binding, possibly nucleic acid-binding protein
GIS01_10960	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_10965	COG2200	EAL domain
GIS01_11120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_11130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIS01_11140	COG0582	viral genome integration into host DNA
GIS01_11145	COG0424	maF-like protein
GIS01_11160	COG1530	ribonuclease E activity
GIS01_11170	COG0306	phosphate transporter
GIS01_11175	COG0717	Belongs to the dCTP deaminase family
GIS01_11180	COG0572	uridine kinase
GIS01_11185	COG0489	protein tyrosine kinase activity
GIS01_11190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_11190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_11200	COG1254	Belongs to the acylphosphatase family
GIS01_11205	COG0840	transmembrane signaling receptor activity
GIS01_11210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GIS01_11225	COG0709	Synthesizes selenophosphate from selenide and ATP
GIS01_11230	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GIS01_11235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIS01_11245	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_11250	COG2267	carboxylic ester hydrolase activity
GIS01_11260	COG1214	PFAM Peptidase M22, glycoprotease
GIS01_11265	COG1199	ATP-dependent helicase activity
GIS01_11275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GIS01_11280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GIS01_11285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GIS01_11290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GIS01_11290	COG0131	Imidazoleglycerol-phosphate dehydratase
GIS01_11295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GIS01_11300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GIS01_11305	COG0107	imidazoleglycerol-phosphate synthase activity
GIS01_11320	COG3706	GGDEF domain
GIS01_11325	COG0318	PFAM AMP-dependent synthetase and ligase
GIS01_11335	COG3134	Outer membrane lipoprotein
GIS01_11340	COG2080	2 iron, 2 sulfur cluster binding
GIS01_11345	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIS01_11350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIS01_11355	COG2252	PERMEase
GIS01_11360	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_11365	COG2233	PERMEase
GIS01_11370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GIS01_11370	COG2080	2 iron, 2 sulfur cluster binding
GIS01_11375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GIS01_11380	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_11385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_11385	COG0493	'glutamate synthase
GIS01_11395	COG2068	MobA-Related Protein
GIS01_11400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GIS01_11405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GIS01_11405	COG3608	succinylglutamate desuccinylase aspartoacylase
GIS01_11415	COG0697	spore germination
GIS01_11420	COG0549	Belongs to the carbamate kinase family
GIS01_11430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GIS01_11435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GIS01_11440	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GIS01_11475	COG0242	peptide deformylase activity
GIS01_11485	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GIS01_11490	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GIS01_11495	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GIS01_11505	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GIS01_11510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GIS01_11520	COG0205	6-phosphofructokinase activity
GIS01_11530	COG3123	guanosine phosphorylase activity
GIS01_11535	COG1760	l-serine dehydratase
GIS01_11540	COG1760	l-serine dehydratase
GIS01_11545	COG3100	YcgL domain-containing protein
GIS01_11550	COG0850	regulation of cytokinetic process
GIS01_11555	COG2894	cell division
GIS01_11560	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GIS01_11570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIS01_11610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GIS01_11615	COG0697	spore germination
GIS01_11620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GIS01_11625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_11635	COG0307	riboflavin synthase, alpha
GIS01_11650	COG0534	Mate efflux family protein
GIS01_11695	COG4681	YaeQ
GIS01_11710	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIS01_11715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GIS01_11720	COG0586	Pfam SNARE associated Golgi protein
GIS01_11730	COG0556	nucleotide-excision repair
GIS01_11745	COG2985	domain, Protein
GIS01_11745	COG0569	domain protein
GIS01_11755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GIS01_11760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_11760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GIS01_11775	COG3069	C4-dicarboxylate transmembrane transporter activity
GIS01_11790	COG1451	nucleotide metabolic process
GIS01_11805	COG0417	DNA replication proofreading
GIS01_11830	COG1560	Kdo2-lipid A biosynthetic process
GIS01_11835	COG1560	Kdo2-lipid A biosynthetic process
GIS01_11850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GIS01_11855	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GIS01_11865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GIS01_11870	COG2832	Protein of unknown function (DUF454)
GIS01_11875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GIS01_11890	COG1011	Hydrolase
GIS01_11895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GIS01_11920	COG3593	DNA synthesis involved in DNA repair
GIS01_11935	COG0583	DNA-binding transcription factor activity
GIS01_11940	COG0730	response to heat
GIS01_11950	COG1846	Transcriptional regulator
GIS01_11950	COG1940	carbohydrate kinase activity
GIS01_11955	COG0840	transmembrane signaling receptor activity
GIS01_11960	COG3012	SEC-C Motif Domain Protein
GIS01_11965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GIS01_11970	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GIS01_11975	COG0247	lactate metabolic process
GIS01_11990	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GIS01_11995	COG0437	4 iron, 4 sulfur cluster binding
GIS01_12000	COG3301	Polysulphide reductase, NrfD
GIS01_12005	COG1138	Cytochrome C-type biogenesis protein
GIS01_12010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_12015	COG3088	subunit of a heme lyase
GIS01_12015	COG4235	cytochrome complex assembly
GIS01_12025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_12035	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GIS01_12045	COG1840	ABC-type Fe3 transport system, periplasmic component
GIS01_12050	COG3842	ATPase activity
GIS01_12060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_12080	COG0045	succinate-CoA ligase (ADP-forming) activity
GIS01_12085	COG0508	dehydrogenase complex catalyzes the overall conversion of
GIS01_12090	COG0567	Dehydrogenase, E1 component
GIS01_12100	COG1053	succinate dehydrogenase
GIS01_12105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GIS01_12110	COG2009	succinate dehydrogenase
GIS01_12125	COG0456	acetyltransferase
GIS01_12145	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GIS01_12160	COG2501	S4 domain
GIS01_12170	COG1132	(ABC) transporter
GIS01_12175	COG1132	(ABC) transporter
GIS01_12185	COG3118	belongs to the thioredoxin family
GIS01_12190	COG0471	metal ion transport
GIS01_12195	COG0058	SHG alpha-glucan phosphorylase activity
GIS01_12210	COG0697	spore germination
GIS01_12220	COG2062	phosphohistidine phosphatase, SixA
GIS01_12225	COG1025	Belongs to the peptidase M16 family
GIS01_12230	COG0500	methyltransferase
GIS01_12250	COG1129	ABC transporter
GIS01_12260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GIS01_12260	COG0519	Catalyzes the synthesis of GMP from XMP
GIS01_12265	COG0516	GMP reductase activity
GIS01_12265	COG0517	IMP dehydrogenase activity
GIS01_12275	COG1570	exodeoxyribonuclease VII activity
GIS01_12280	COG2188	Transcriptional regulator
GIS01_12290	COG0383	alpha-mannosidase activity
GIS01_12295	COG1181	Belongs to the D-alanine--D-alanine ligase family
GIS01_12305	COG0386	Belongs to the glutathione peroxidase family
GIS01_12310	COG0513	Belongs to the DEAD box helicase family
GIS01_12325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_12330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GIS01_12335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GIS01_12355	COG0598	Magnesium transport protein CorA
GIS01_12385	COG5001	Diguanylate cyclase
GIS01_12385	COG3300	MHYT domain
GIS01_12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_12410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GIS01_12415	COG0563	adenylate kinase activity
GIS01_12425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GIS01_12430	COG1286	toxin biosynthetic process
GIS01_12435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GIS01_12440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GIS01_12445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GIS01_12450	COG0531	amino acid
GIS01_12450	COG1674	ftsk spoiiie
GIS01_12460	COG0686	Belongs to the AlaDH PNT family
GIS01_12465	COG0492	ferredoxin-NADP+ reductase activity
GIS01_12470	COG3706	GGDEF domain
GIS01_12475	COG3134	Outer membrane lipoprotein
GIS01_12480	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GIS01_12485	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GIS01_12490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GIS01_12495	COG0542	response to heat
GIS01_12500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GIS01_12505	COG1278	Cold shock
GIS01_12510	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GIS01_12530	COG0745	RESPONSE REGULATOR receiver
GIS01_12535	COG2205	protein histidine kinase activity
GIS01_12545	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GIS01_12545	COG0392	lysyltransferase activity
GIS01_12570	COG1435	thymidine kinase activity
GIS01_12575	COG1757	Na H antiporter
GIS01_12580	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_12585	COG2096	Adenosyltransferase
GIS01_12590	COG3530	Putative quorum-sensing-regulated virulence factor
GIS01_12595	COG0602	queuosine metabolic process
GIS01_12600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GIS01_12620	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GIS01_12630	COG0776	regulation of translation
GIS01_12635	COG0539	negative regulation of cytoplasmic translation
GIS01_12640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GIS01_12645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIS01_12660	COG2814	Major facilitator Superfamily
GIS01_12675	COG0778	Nitroreductase
GIS01_12680	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GIS01_12685	COG5001	Diguanylate cyclase
GIS01_12685	COG3300	MHYT domain
GIS01_12690	COG0583	DNA-binding transcription factor activity
GIS01_12695	COG3437	response regulator, receiver
GIS01_12720	COG4989	oxidoreductase activity
GIS01_12725	COG0724	RNA recognition motif
GIS01_12735	COG1126	abc transporter atp-binding protein
GIS01_12740	COG0765	amino acid transport
GIS01_12745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_12750	COG4597	amino acid ABC transporter
GIS01_12755	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GIS01_12765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GIS01_12780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_12785	COG1360	Flagellar Motor Protein
GIS01_12795	COG1770	oligopeptidase
GIS01_12815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_12820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_12825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_12825	COG0649	NAD binding
GIS01_12840	COG1034	ATP synthesis coupled electron transport
GIS01_12845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GIS01_12850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_12855	COG0839	Belongs to the complex I subunit 6 family
GIS01_12860	COG0713	ATP synthesis coupled electron transport
GIS01_12870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_12875	COG1007	ATP synthesis coupled electron transport
GIS01_12890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_12890	COG2199	diguanylate cyclase activity
GIS01_12895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GIS01_12895	COG0047	phosphoribosylformylglycinamidine synthase activity
GIS01_12900	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GIS01_12905	COG1645	bacterial-type flagellum-dependent swarming motility
GIS01_12910	COG1160	GTP binding
GIS01_12915	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_12920	COG2976	Protein conserved in bacteria
GIS01_12925	COG0124	histidyl-tRNA synthetase
GIS01_12945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GIS01_12950	COG0105	UTP biosynthetic process
GIS01_12965	COG0633	Ferredoxin
GIS01_12970	COG0443	Heat shock 70 kDa protein
GIS01_12975	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GIS01_12985	COG0822	iron-sulfur transferase activity
GIS01_12990	COG1104	cysteine desulfurase activity
GIS01_13035	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_13040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GIS01_13045	COG1862	Preprotein translocase
GIS01_13050	COG0343	queuine tRNA-ribosyltransferase activity
GIS01_13055	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GIS01_13060	COG0517	IMP dehydrogenase activity
GIS01_13065	COG0450	alkyl hydroperoxide reductase
GIS01_13070	COG3634	alkyl hydroperoxide reductase activity
GIS01_13115	COG1242	4 iron, 4 sulfur cluster binding
GIS01_13120	COG0067	glutamate synthase
GIS01_13120	COG0070	glutamate synthase
GIS01_13120	COG0069	glutamate synthase activity
GIS01_13125	COG0493	'glutamate synthase
GIS01_13135	COG0513	Belongs to the DEAD box helicase family
GIS01_13160	COG0023	Translation Initiation Factor
GIS01_13165	COG2119	membrane
GIS01_13215	COG0215	cysteine-tRNA ligase activity
GIS01_13220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GIS01_13230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GIS01_13240	COG2261	transglycosylase associated protein
GIS01_13245	COG0642	Histidine kinase
GIS01_13290	COG0322	excinuclease ABC activity
GIS01_13295	COG2197	response regulator
GIS01_13300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GIS01_13305	COG2835	tetraacyldisaccharide 4'-kinase activity
GIS01_13310	COG1663	tetraacyldisaccharide 4'-kinase activity
GIS01_13320	COG2333	competence protein COMEC
GIS01_13320	COG0658	competence protein
GIS01_13335	COG1448	Aminotransferase
GIS01_13360	COG0708	Exodeoxyribonuclease III
GIS01_13385	COG1122	ATPase activity
GIS01_13410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_13415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_13430	COG1120	ATPase activity
GIS01_13435	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_13440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_13445	COG4771	TonB-dependent receptor
GIS01_13450	COG2375	cellular response to nickel ion
GIS01_13455	COG0784	Response regulator, receiver
GIS01_13455	COG3437	response regulator, receiver
GIS01_13465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_13470	COG0328	RNA-DNA hybrid ribonuclease activity
GIS01_13475	COG2226	methyltransferase
GIS01_13480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GIS01_13485	COG1388	LysM domain
GIS01_13485	COG0741	lytic transglycosylase activity
GIS01_13510	COG5000	phosphorelay sensor kinase activity
GIS01_13510	COG5002	protein histidine kinase activity
GIS01_13515	COG0745	RESPONSE REGULATOR receiver
GIS01_13520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GIS01_13525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_13545	COG0583	DNA-binding transcription factor activity
GIS01_13550	COG3085	chromosome segregation
GIS01_13555	COG4574	serine-type endopeptidase inhibitor activity
GIS01_13560	COG0584	glycerophosphoryl diester phosphodiesterase
GIS01_13570	COG1349	DNA-binding transcription factor activity
GIS01_13575	COG2271	Major facilitator Superfamily
GIS01_13580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GIS01_13585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GIS01_13590	COG0840	transmembrane signaling receptor activity
GIS01_13600	COG0583	DNA-binding transcription factor activity
GIS01_13625	COG0656	L-ascorbic acid biosynthetic process
GIS01_13635	COG2814	Major facilitator Superfamily
GIS01_13640	COG2249	NAD(P)H dehydrogenase (quinone) activity
GIS01_13655	COG3220	belongs to the UPF0276 family
GIS01_13675	COG1294	oxidase, subunit
GIS01_13685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_13695	COG2979	Protein of unknown function (DUF533)
GIS01_13710	COG0583	DNA-binding transcription factor activity
GIS01_13720	COG2807	transmembrane transport
GIS01_13725	COG1187	pseudouridine synthase activity
GIS01_13735	COG0346	lactoylglutathione lyase activity
GIS01_13745	COG1061	Type III restriction enzyme res subunit
GIS01_13750	COG4657	Part of a membrane complex involved in electron transport
GIS01_13755	COG2878	Part of a membrane complex involved in electron transport
GIS01_13765	COG4658	electron transport chain
GIS01_13770	COG4659	FMN binding
GIS01_13780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GIS01_13785	COG0346	lactoylglutathione lyase activity
GIS01_13825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GIS01_13830	COG0505	Belongs to the CarA family
GIS01_13835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GIS01_13850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GIS01_13855	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GIS01_13860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GIS01_13865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GIS01_13870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GIS01_13875	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GIS01_13905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GIS01_13910	COG0861	Integral membrane protein TerC family
GIS01_13920	COG0444	Belongs to the ABC transporter superfamily
GIS01_13925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_13930	COG0601	transmembrane transport
GIS01_13940	COG2095	MarC family integral membrane protein
GIS01_13945	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_13945	COG1454	alcohol dehydrogenase
GIS01_13955	COG0217	transcriptional regulatory protein
GIS01_13960	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GIS01_13970	COG1801	Protein of unknown function DUF72
GIS01_13975	COG4106	trans-aconitate 2-methyltransferase activity
GIS01_13980	COG0500	methyltransferase
GIS01_14000	COG0450	alkyl hydroperoxide reductase
GIS01_14005	COG0583	DNA-binding transcription factor activity
GIS01_14010	COG0791	NLP P60 protein
GIS01_14020	COG0583	DNA-binding transcription factor activity
GIS01_14030	COG3048	D-serine ammonia-lyase activity
GIS01_14040	COG0538	isocitrate dehydrogenase activity
GIS01_14045	COG2207	Transcriptional regulator
GIS01_14050	COG1482	cell wall glycoprotein biosynthetic process
GIS01_14055	COG0840	transmembrane signaling receptor activity
GIS01_14060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_14075	COG3152	Membrane
GIS01_14110	COG1309	transcriptional regulator
GIS01_14140	COG0534	Mate efflux family protein
GIS01_14150	COG2841	Protein conserved in bacteria
GIS01_14155	COG1653	transport
GIS01_14160	COG3300	MHYT domain
GIS01_14160	COG5001	Diguanylate cyclase
GIS01_14165	COG3132	Protein of unknown function, DUF480
GIS01_14190	COG1376	ErfK ybiS ycfS ynhG family protein
GIS01_14190	COG1388	LysM domain
GIS01_14200	COG0471	metal ion transport
GIS01_14210	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GIS01_14215	COG0791	NLP P60 protein
GIS01_14225	COG3118	belongs to the thioredoxin family
GIS01_14235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GIS01_14240	COG0788	formyltetrahydrofolate deformylase activity
GIS01_14250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_14265	COG1196	nuclear chromosome segregation
GIS01_14265	COG0739	heme binding
GIS01_14265	COG0741	lytic transglycosylase activity
GIS01_14270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GIS01_14280	COG0436	Aminotransferase
GIS01_14285	COG1288	antiporter activity
GIS01_14290	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GIS01_14375	COG4397	Mu-like prophage major head subunit gpT
GIS01_14380	COG4388	Caudovirus prohead serine protease
GIS01_14410	COG4383	Mu-like prophage protein gp29
GIS01_14415	COG4373	Mu-like prophage FluMu protein gp28
GIS01_14425	COG0640	Transcriptional regulator
GIS01_14545	COG2932	Transcriptional regulator
GIS01_14560	COG2964	Protein conserved in bacteria
GIS01_14565	COG3681	Belongs to the UPF0597 family
GIS01_14575	COG0814	amino acid
GIS01_14595	COG1166	arginine decarboxylase activity
GIS01_14600	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_14615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GIS01_14625	COG2353	YceI-like domain
GIS01_14630	COG0583	DNA-binding transcription factor activity
GIS01_14640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GIS01_14645	COG0840	transmembrane signaling receptor activity
GIS01_14650	COG0302	gtp cyclohydrolase
GIS01_14655	COG0303	'Molybdopterin
GIS01_14660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GIS01_14675	COG2267	carboxylic ester hydrolase activity
GIS01_14680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GIS01_14695	COG0314	molybdopterin synthase activity
GIS01_14700	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GIS01_14705	COG0315	cyclic pyranopterin monophosphate synthase activity
GIS01_14710	COG0521	Mo-molybdopterin cofactor biosynthetic process
GIS01_14715	COG3005	denitrification pathway
GIS01_14725	COG0348	domain, Protein
GIS01_14730	COG0437	4 iron, 4 sulfur cluster binding
GIS01_14735	COG0243	molybdopterin cofactor binding
GIS01_14745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_14750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GIS01_14755	COG3850	Histidine kinase
GIS01_14760	COG2197	response regulator
GIS01_14770	COG2205	protein histidine kinase activity
GIS01_14770	COG0784	Response regulator, receiver
GIS01_14790	COG0121	glutamine amidotransferase
GIS01_14795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GIS01_14800	COG1960	acyl-CoA dehydrogenase activity
GIS01_14805	COG1473	amidohydrolase
GIS01_14815	COG2867	negative regulation of translational initiation
GIS01_14820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GIS01_15050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GIS01_15085	COG0270	DNA (cytosine-5-)-methyltransferase activity
GIS01_15120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GIS01_15150	COG2974	May be involved in recombination
GIS01_15220	COG0784	Response regulator, receiver
GIS01_15220	COG2205	protein histidine kinase activity
GIS01_15230	COG3383	formate dehydrogenase (NAD+) activity
GIS01_15240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GIS01_15250	COG1960	acyl-CoA dehydrogenase activity
GIS01_15255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GIS01_15265	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GIS01_15270	COG1317	bacterial-type flagellum organization
GIS01_15360	COG0457	Tetratricopeptide repeat
GIS01_15430	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_15435	COG4790	Type iii secretion
GIS01_15440	COG4794	Type iii secretion
GIS01_15445	COG4791	protein targeting
GIS01_15450	COG4792	protein secretion
GIS01_15465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GIS01_15470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GIS01_15470	COG1263	PTS System
GIS01_15475	COG1609	Transcriptional regulator
GIS01_15485	COG4821	SIS domain
GIS01_15500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_15500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_15500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_15505	COG2271	Major facilitator Superfamily
GIS01_15510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GIS01_15520	COG1187	pseudouridine synthase activity
GIS01_15530	COG0482	sulfurtransferase activity
GIS01_15535	COG2915	High frequency lysogenization protein hflD homolog
GIS01_15540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GIS01_15545	COG2850	peptidyl-arginine hydroxylation
GIS01_15565	COG0625	glutathione transferase activity
GIS01_15570	COG0259	pyridoxamine-phosphate oxidase activity
GIS01_15610	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_15610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_15615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GIS01_15625	COG2853	Lipoprotein
GIS01_15635	COG3088	subunit of a heme lyase
GIS01_15635	COG4235	cytochrome complex assembly
GIS01_15640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GIS01_15645	COG1138	Cytochrome C-type biogenesis protein
GIS01_15650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GIS01_15655	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_15660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_15665	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GIS01_15680	COG0835	chemotaxis
GIS01_15690	COG1192	Involved in chromosome partitioning
GIS01_15695	COG1360	Flagellar Motor Protein
GIS01_15700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GIS01_15705	COG2201	protein-glutamate methylesterase activity
GIS01_15710	COG0643	Histidine kinase
GIS01_15710	COG2198	Histidine kinase
GIS01_15715	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GIS01_15730	COG0455	bacterial-type flagellum organization
GIS01_15740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GIS01_15750	COG1684	flagellar biosynthetic protein fliR
GIS01_15755	COG1987	bacterial-type flagellum assembly
GIS01_15805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GIS01_15815	COG1677	Flagellar hook-basal body complex protein FliE
GIS01_15835	COG0469	pyruvate kinase activity
GIS01_15840	COG1737	Transcriptional regulator
GIS01_15845	COG0837	glucose binding
GIS01_15875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_15895	COG0281	malic enzyme
GIS01_15915	COG0437	4 iron, 4 sulfur cluster binding
GIS01_15920	COG3383	formate dehydrogenase (NAD+) activity
GIS01_15920	COG3383	formate dehydrogenase (NAD+) activity
GIS01_15960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GIS01_15970	COG3852	Histidine kinase
GIS01_15975	COG2204	response regulator
GIS01_15985	COG4662	Binding-protein-dependent transport system inner membrane component
GIS01_15995	COG0746	molybdenum cofactor guanylyltransferase activity
GIS01_16000	COG0303	'Molybdopterin
GIS01_16005	COG1289	transmembrane transporter activity
GIS01_16010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GIS01_16040	COG3220	belongs to the UPF0276 family
GIS01_16070	COG2205	protein histidine kinase activity
GIS01_16070	COG0784	Response regulator, receiver
GIS01_16085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GIS01_16090	COG0444	Belongs to the ABC transporter superfamily
GIS01_16095	COG4608	Belongs to the ABC transporter superfamily
GIS01_16105	COG2971	BadF BadG BcrA BcrD
GIS01_16115	COG0840	transmembrane signaling receptor activity
GIS01_16125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GIS01_16130	COG3724	N-succinylarginine dihydrolase activity
GIS01_16160	COG2197	response regulator
GIS01_16190	COG2200	EAL domain
GIS01_16190	COG2203	Gaf domain
GIS01_16190	COG2199	diguanylate cyclase activity
GIS01_16200	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GIS01_16210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GIS01_16215	COG3706	GGDEF domain
GIS01_16220	COG2211	Major facilitator Superfamily
GIS01_16225	COG0616	signal peptide processing
GIS01_16230	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_16235	COG0583	DNA-binding transcription factor activity
GIS01_16245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GIS01_16265	COG1881	PFAM PEBP family protein
GIS01_16285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GIS01_16300	COG1301	dicarboxylic acid transport
GIS01_16305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GIS01_16310	COG2912	Transglutaminase-like superfamily
GIS01_16320	COG2890	protein-(glutamine-N5) methyltransferase activity
GIS01_16325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GIS01_16330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GIS01_16335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GIS01_16340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GIS01_16350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GIS01_16355	COG0737	Belongs to the 5'-nucleotidase family
GIS01_16360	COG0193	aminoacyl-tRNA hydrolase activity
GIS01_16365	COG0012	GTP binding
GIS01_16410	COG0490	domain, Protein
GIS01_16410	COG0471	metal ion transport
GIS01_16420	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GIS01_16440	COG0366	Alpha amylase catalytic
GIS01_16445	COG1013	pyruvate-flavodoxin oxidoreductase activity
GIS01_16445	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GIS01_16445	COG0674	pyruvate-flavodoxin oxidoreductase activity
GIS01_16445	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GIS01_16455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_16470	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_16480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GIS01_16485	COG0512	Glutamine amidotransferase of anthranilate synthase
GIS01_16495	COG0180	Tryptophanyl-tRNA synthetase
GIS01_16505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GIS01_16510	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GIS01_16520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GIS01_16525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GIS01_16555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GIS01_16560	COG0583	DNA-binding transcription factor activity
GIS01_16580	COG0583	DNA-binding transcription factor activity
GIS01_16590	COG0739	heme binding
GIS01_16600	COG3264	Mechanosensitive ion channel
GIS01_16600	COG1511	domain protein
GIS01_16605	COG0584	glycerophosphoryl diester phosphodiesterase
GIS01_16615	COG1053	succinate dehydrogenase
GIS01_16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GIS01_16625	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GIS01_16630	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GIS01_16635	COG3366	ferrous iron transmembrane transporter activity
GIS01_16640	COG0700	Nucleoside recognition
GIS01_16645	COG2195	Cleaves the N-terminal amino acid of tripeptides
GIS01_16655	COG3214	Protein conserved in bacteria
GIS01_16670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_16685	COG1022	Amp-dependent synthetase and ligase
GIS01_16695	COG4221	oxidoreductase activity
GIS01_16705	COG0745	RESPONSE REGULATOR receiver
GIS01_16710	COG0642	Histidine kinase
GIS01_16730	COG0516	GMP reductase activity
GIS01_16740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GIS01_16750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GIS01_16775	COG0583	DNA-binding transcription factor activity
GIS01_16780	COG3706	GGDEF domain
GIS01_16790	COG1335	isochorismatase
GIS01_16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GIS01_16800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GIS01_16805	COG1702	phosphate starvation-inducible protein PhoH
GIS01_16810	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GIS01_16815	COG4535	Mg2 and Co2 transporter CorC
GIS01_16820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GIS01_16825	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GIS01_16835	COG0789	Transcriptional regulator
GIS01_16850	COG1970	mechanosensitive ion channel activity
GIS01_16855	COG4974	Belongs to the 'phage' integrase family
GIS01_16860	COG0716	FMN binding
GIS01_16870	COG0312	modulator of DNA gyrase
GIS01_16875	COG2888	peptidyl-tyrosine sulfation
GIS01_16880	COG0495	leucyl-tRNA aminoacylation
GIS01_16895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GIS01_16900	COG0799	negative regulation of ribosome biogenesis
GIS01_16905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GIS01_16910	COG0768	penicillin binding
GIS01_16915	COG0772	Belongs to the SEDS family
GIS01_16920	COG2951	lytic endotransglycosylase activity
GIS01_16925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GIS01_16930	COG1686	Belongs to the peptidase S11 family
GIS01_16935	COG2921	Belongs to the UPF0250 family
GIS01_16940	COG0321	lipoyl(octanoyl) transferase activity
GIS01_16945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GIS01_16965	COG3139	Protein of unknown function (DUF1315)
GIS01_16970	COG0252	asparaginase activity
GIS01_16975	COG0786	glutamate:sodium symporter activity
GIS01_16990	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GIS01_16995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GIS01_17000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GIS01_17015	COG3610	response to peptide
GIS01_17020	COG2966	Psort location CytoplasmicMembrane, score
GIS01_17030	COG0521	Mo-molybdopterin cofactor biosynthetic process
GIS01_17045	COG2897	thiosulfate sulfurtransferase activity
GIS01_17050	COG2066	Belongs to the glutaminase family
GIS01_17055	COG3171	Protein conserved in bacteria
GIS01_17060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GIS01_17065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_17070	COG2200	EAL domain
GIS01_17075	COG1090	epimerase
GIS01_17080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GIS01_17085	COG4181	ATPase activity
GIS01_17090	COG2755	lipolytic protein G-D-S-L family
GIS01_17095	COG0784	Response regulator, receiver
GIS01_17095	COG0835	chemotaxis
GIS01_17145	COG3397	chitin binding
GIS01_17165	COG5002	protein histidine kinase activity
GIS01_17165	COG2205	protein histidine kinase activity
GIS01_17165	COG0784	Response regulator, receiver
GIS01_17175	COG3655	Transcriptional regulator
GIS01_17185	COG2814	Major facilitator Superfamily
GIS01_17210	COG0748	coenzyme F420 binding
GIS01_17215	COG3721	Heme iron utilization protein
GIS01_17225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GIS01_17245	COG0432	Pfam Uncharacterised protein family UPF0047
GIS01_17250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GIS01_17255	COG0305	Participates in initiation and elongation during chromosome replication
GIS01_17270	COG1047	Peptidyl-prolyl cis-trans
GIS01_17275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GIS01_17285	COG0784	Response regulator, receiver
GIS01_17285	COG0835	chemotaxis
GIS01_17290	COG0429	hydrolase of the alpha beta-hydrolase fold
GIS01_17295	COG5001	Diguanylate cyclase
GIS01_17295	COG4251	negative regulation of phosphorylation
GIS01_17295	COG3706	GGDEF domain
GIS01_17295	COG2203	Gaf domain
GIS01_17300	COG3089	Belongs to the UPF0270 family
GIS01_17305	COG3954	Phosphoribulokinase
GIS01_17320	COG1765	OsmC-like protein
GIS01_17325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_17360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_17365	COG2313	pseudouridylate synthase activity
GIS01_17395	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GIS01_17415	COG0569	domain protein
GIS01_17415	COG2985	domain, Protein
GIS01_17420	COG1272	protein, Hemolysin III
GIS01_17425	COG0076	glutamate decarboxylase activity
GIS01_17430	COG2917	probably involved in intracellular septation
GIS01_17435	COG2350	Protein conserved in bacteria
GIS01_17445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GIS01_17450	COG1381	Involved in DNA repair and RecF pathway recombination
GIS01_17465	COG0681	Belongs to the peptidase S26 family
GIS01_17470	COG0481	GTPase activity
GIS01_17480	COG3026	antisigma factor binding
GIS01_17485	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GIS01_17490	COG1595	DNA-templated transcription, initiation
GIS01_17495	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GIS01_17505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GIS01_17510	COG0354	folic acid binding
GIS01_17535	COG4232	protein-disulfide reductase activity
GIS01_17555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GIS01_17560	COG0191	fructose-bisphosphate aldolase activity
GIS01_17565	COG0126	phosphoglycerate kinase activity
GIS01_17570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GIS01_17575	COG1940	carbohydrate kinase activity
GIS01_17580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GIS01_17585	COG2816	NAD+ diphosphatase activity
GIS01_17595	COG4991	sh3 domain protein
GIS01_17600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GIS01_17615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GIS01_17640	COG4191	Histidine kinase
GIS01_17705	COG1858	cytochrome C peroxidase
GIS01_17710	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GIS01_17720	COG2203	Gaf domain
GIS01_17720	COG2199	diguanylate cyclase activity
GIS01_17725	COG0513	Belongs to the DEAD box helicase family
GIS01_17755	COG0154	amidase activity
GIS01_17760	COG2957	Belongs to the agmatine deiminase family
GIS01_17780	COG1902	pentaerythritol trinitrate reductase activity
GIS01_17795	COG1238	metal cluster binding
GIS01_17800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GIS01_17805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GIS01_17810	COG0585	pseudouridine synthase activity
GIS01_17820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GIS01_17825	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GIS01_17830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GIS01_17840	COG1376	ErfK ybiS ycfS ynhG family protein
GIS01_17845	COG0668	transmembrane transport
GIS01_17855	COG2731	YhcH YjgK YiaL family protein
GIS01_17865	COG1794	racemase activity, acting on amino acids and derivatives
GIS01_17880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GIS01_17900	COG0488	(ABC) transporter
GIS01_17910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GIS01_17955	COG0148	phosphopyruvate hydratase activity
GIS01_17960	COG0504	CTP synthase activity
GIS01_17965	COG3956	TIGRFAM MazG family protein
GIS01_17970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GIS01_17975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_17985	COG4807	Protein conserved in bacteria
GIS01_17990	COG3023	N-Acetylmuramoyl-L-alanine amidase
GIS01_17995	COG0783	Belongs to the Dps family
GIS01_18000	COG1151	hydroxylamine reductase activity
GIS01_18005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_18010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GIS01_18015	COG0671	phosphoesterase, PA-phosphatase related
GIS01_18020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GIS01_18025	COG0163	prenyltransferase activity
GIS01_18040	COG1131	(ABC) transporter
GIS01_18045	COG0842	Transport permease protein
GIS01_18050	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GIS01_18055	COG1924	4 iron, 4 sulfur cluster binding
GIS01_18080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GIS01_18085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GIS01_18090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GIS01_18100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GIS01_18105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GIS01_18110	COG1489	DNA binding
GIS01_18120	COG1643	Atp-dependent helicase
GIS01_18125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GIS01_18130	COG0346	lactoylglutathione lyase activity
GIS01_18135	COG2076	Multidrug Resistance protein
GIS01_18140	COG2076	Multidrug Resistance protein
GIS01_18150	COG3437	response regulator, receiver
GIS01_18150	COG0784	Response regulator, receiver
GIS01_18155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GIS01_18170	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GIS01_18205	COG0840	transmembrane signaling receptor activity
GIS01_18220	COG0529	Catalyzes the synthesis of activated sulfate
GIS01_18225	COG0471	metal ion transport
GIS01_18225	COG3273	potassium ion transport
GIS01_18230	COG2895	sulfate adenylyltransferase (ATP) activity
GIS01_18235	COG0175	sulfate reduction
GIS01_18240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GIS01_18240	COG1648	precorrin-2 dehydrogenase activity
GIS01_18245	COG0330	HflC and HflK could
GIS01_18250	COG1585	Membrane protein implicated in regulation of membrane protease activity
GIS01_18255	COG0840	transmembrane signaling receptor activity
GIS01_18260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GIS01_18265	COG0676	glucose-6-phosphate 1-epimerase activity
GIS01_18270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GIS01_18275	COG1640	4-alpha-glucanotransferase
GIS01_18280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GIS01_18315	COG1522	sequence-specific DNA binding
GIS01_18330	COG0561	phosphatase activity
GIS01_18345	COG0733	neurotransmitter:sodium symporter activity
GIS01_18355	COG0733	neurotransmitter:sodium symporter activity
GIS01_18380	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GIS01_18385	COG2885	chlorophyll binding
GIS01_18390	COG0823	Involved in the tonB-independent uptake of proteins
GIS01_18405	COG0811	peptide transport
GIS01_18410	COG0824	Thioesterase
GIS01_18415	COG3790	cyd operon protein YbgE
GIS01_18420	COG4890	Cyd operon protein YbgT
GIS01_18425	COG1294	oxidase, subunit
GIS01_18435	COG2255	four-way junction helicase activity
GIS01_18440	COG0632	four-way junction helicase activity
GIS01_18445	COG0840	transmembrane signaling receptor activity
GIS01_18455	COG2771	luxR family
GIS01_18460	COG3916	Acyl-homoserine-lactone synthase
GIS01_18470	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GIS01_18475	COG5001	Diguanylate cyclase
GIS01_18475	COG4251	negative regulation of phosphorylation
GIS01_18475	COG3706	GGDEF domain
GIS01_18475	COG2203	Gaf domain
GIS01_18485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GIS01_18495	COG2995	paraquat-inducible protein a
GIS01_18500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GIS01_18500	COG3008	intermembrane lipid transfer
GIS01_18510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GIS01_18515	COG0442	prolyl-tRNA aminoacylation
GIS01_18520	COG4221	oxidoreductase activity
GIS01_18535	COG1024	Enoyl-CoA hydratase
GIS01_18545	COG0110	maltose O-acetyltransferase activity
GIS01_18555	COG4166	transmembrane transport
GIS01_18565	COG0840	transmembrane signaling receptor activity
GIS01_18575	COG2918	glutathione biosynthetic process
GIS01_18580	COG0612	Peptidase, M16
GIS01_18585	COG1238	metal cluster binding
GIS01_18590	COG1064	alcohol dehydrogenase
GIS01_18615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_18620	COG0359	binds to the 23S rRNA
GIS01_18625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GIS01_18630	COG0360	Binds together with S18 to 16S ribosomal RNA
GIS01_18635	COG1914	H( )-stimulated, divalent metal cation uptake system
GIS01_18640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GIS01_18650	COG0776	regulation of translation
GIS01_18665	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GIS01_18680	COG0560	Phosphoserine phosphatase
GIS01_18690	COG0813	purine-nucleoside phosphorylase activity
GIS01_18695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GIS01_18700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GIS01_18705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GIS01_18715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_18720	COG0084	hydrolase, TatD family'
GIS01_18725	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_18730	COG1854	S-ribosylhomocysteine lyase activity
GIS01_18745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GIS01_18745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GIS01_18785	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_18790	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GIS01_18795	COG1047	Peptidyl-prolyl cis-trans
GIS01_18800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GIS01_18805	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GIS01_18810	COG0196	riboflavin kinase activity
GIS01_18815	COG0728	peptidoglycan biosynthetic process
GIS01_18820	COG0268	Binds directly to 16S ribosomal RNA
GIS01_18825	COG0640	Transcriptional regulator
GIS01_18830	COG0583	DNA-binding transcription factor activity
GIS01_18840	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GIS01_18845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GIS01_18850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GIS01_18855	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GIS01_18860	COG1051	belongs to the nudix hydrolase family
GIS01_18865	COG3066	DNA modification
GIS01_18875	COG0335	large ribosomal subunit rRNA binding
GIS01_18880	COG0336	Belongs to the RNA methyltransferase TrmD family
GIS01_18885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GIS01_18890	COG0228	four-way junction DNA binding
GIS01_18895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GIS01_18900	COG4137	Cytochrome C assembly protein
GIS01_18905	COG4536	flavin adenine dinucleotide binding
GIS01_18915	COG1017	nitric oxide dioxygenase activity
GIS01_18915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GIS01_18920	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GIS01_18925	COG0039	L-malate dehydrogenase activity
GIS01_18930	COG4160	amino acid transport
GIS01_18935	COG4215	(ABC) transporter
GIS01_18940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_18945	COG1126	abc transporter atp-binding protein
GIS01_18950	COG1438	arginine binding
GIS01_18965	COG1872	DUF167
GIS01_18970	COG0762	integral membrane protein
GIS01_18975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GIS01_18980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GIS01_18995	COG3022	response to hydroperoxide
GIS01_19015	COG0347	Belongs to the P(II) protein family
GIS01_19020	COG1840	ABC-type Fe3 transport system, periplasmic component
GIS01_19030	COG3842	ATPase activity
GIS01_19035	COG2837	iron assimilation
GIS01_19040	COG3385	transposase activity
GIS01_19045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GIS01_19050	COG0583	DNA-binding transcription factor activity
GIS01_19065	COG1929	Belongs to the glycerate kinase type-1 family
GIS01_19070	COG2610	gluconate transmembrane transporter activity
GIS01_19075	COG3835	regulator
GIS01_19080	COG3112	Uncharacterised protein family (UPF0231)
GIS01_19100	COG3568	Endonuclease Exonuclease Phosphatase
GIS01_19110	COG0513	Belongs to the DEAD box helicase family
GIS01_19150	COG1448	Aminotransferase
GIS01_19165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GIS01_19170	COG1328	CTP reductase activity
GIS01_19185	COG0543	2 iron, 2 sulfur cluster binding
GIS01_19185	COG0633	Ferredoxin
GIS01_19200	COG0840	transmembrane signaling receptor activity
GIS01_19205	COG3397	chitin binding
GIS01_19210	COG0583	DNA-binding transcription factor activity
GIS01_19215	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GIS01_19220	COG4208	sulfate ABC transporter
GIS01_19225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GIS01_19235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GIS01_19240	COG3174	membrane
GIS01_19245	COG0110	maltose O-acetyltransferase activity
GIS01_19260	COG1011	Hydrolase
GIS01_19265	COG0494	nUDIX hydrolase
GIS01_19270	COG1218	3'(2'),5'-bisphosphate nucleotidase
GIS01_19275	COG0814	amino acid
GIS01_19280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_19295	COG0626	cystathionine gamma-synthase activity
GIS01_19300	COG0527	aspartate kinase activity
GIS01_19300	COG0460	homoserine dehydrogenase
GIS01_19305	COG0306	phosphate transporter
GIS01_19310	COG1392	Phosphate transport regulator
GIS01_19320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GIS01_19325	COG2813	Specifically methylates the guanine in position
GIS01_19330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GIS01_19335	COG0297	glycogen (starch) synthase activity
GIS01_19375	COG1757	Na H antiporter
GIS01_19380	COG0316	Belongs to the HesB IscA family
GIS01_19390	COG0038	chloride channel
GIS01_19395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GIS01_19445	COG1396	sequence-specific DNA binding
GIS01_19450	COG3135	benzoate transporter
GIS01_19475	COG0840	transmembrane signaling receptor activity
GIS01_19480	COG3047	cAMP biosynthetic process
GIS01_19485	COG3706	GGDEF domain
GIS01_19490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GIS01_19510	COG1462	curli production assembly transport component CsgG
GIS01_19525	COG2197	response regulator
GIS01_19565	COG5499	transcription regulator containing HTH domain
GIS01_19620	COG1278	Cold shock
GIS01_19625	COG2252	PERMEase
GIS01_19630	COG2376	Dihydroxyacetone kinase
GIS01_19635	COG1461	Dihydroxyacetone kinase
GIS01_19640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GIS01_19640	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GIS01_19640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GIS01_19650	COG3284	Transcriptional regulator
GIS01_19660	COG0628	permease
GIS01_19665	COG0494	nUDIX hydrolase
GIS01_19680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GIS01_19710	COG3133	Outer membrane lipoprotein
GIS01_19715	COG0004	ammonium transporteR
GIS01_19720	COG3706	GGDEF domain
GIS01_19730	COG3932	Exopolysaccharide synthesis, ExoD
GIS01_19735	COG0814	amino acid
GIS01_19740	COG3706	GGDEF domain
GIS01_19750	COG0110	maltose O-acetyltransferase activity
GIS01_19765	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GIS01_19770	COG2022	thiamine diphosphate biosynthetic process
GIS01_19780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GIS01_19785	COG0352	thiamine-phosphate diphosphorylase activity
GIS01_19790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GIS01_19810	COG0745	RESPONSE REGULATOR receiver
GIS01_19820	COG0189	ligase activity
GIS01_19865	COG0477	Major facilitator Superfamily
GIS01_19880	COG0312	modulator of DNA gyrase
GIS01_19885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GIS01_19895	COG3164	Protein of unknown function
GIS01_19900	COG1530	ribonuclease E activity
GIS01_19905	COG0424	maF-like protein
GIS01_19910	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GIS01_19915	COG1792	Involved in formation and maintenance of cell shape
GIS01_19920	COG1077	Cell shape determining protein MreB Mrl
GIS01_19945	COG4968	Prepilin-type N-terminal cleavage methylation domain
GIS01_19950	COG4969	Belongs to the N-Me-Phe pilin family
GIS01_19965	COG1459	type II secretion system
GIS01_19970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GIS01_20015	COG2200	EAL domain
GIS01_20015	COG2199	diguanylate cyclase activity
GIS01_20020	COG2200	EAL domain
GIS01_20025	COG0387	Pfam Sodium calcium exchanger
GIS01_20030	COG2986	histidine ammonia-lyase
GIS01_20035	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GIS01_20040	COG0010	Belongs to the arginase family
GIS01_20045	COG1228	amidohydrolase
GIS01_20050	COG2188	Transcriptional regulator
GIS01_20055	COG0288	reversible hydration of carbon dioxide
GIS01_20065	COG2177	Part of the ABC transporter FtsEX involved in
GIS01_20070	COG2884	Cell division ATP-binding protein ftsE
GIS01_20075	COG0552	protein localization to endoplasmic reticulum
GIS01_20080	COG0742	ribosomal rna small subunit methyltransferase
GIS01_20105	COG2249	NAD(P)H dehydrogenase (quinone) activity
GIS01_20110	COG0583	DNA-binding transcription factor activity
GIS01_20115	COG4221	oxidoreductase activity
GIS01_20130	COG1770	oligopeptidase
GIS01_20145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GIS01_20150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GIS01_20160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_20170	COG2095	MarC family integral membrane protein
GIS01_20180	COG1301	dicarboxylic acid transport
GIS01_20205	COG3714	YhhN family
GIS01_20260	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GIS01_20265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GIS01_20270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GIS01_20275	COG0049	tRNA binding
GIS01_20280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GIS01_20285	COG2168	tRNA wobble position uridine thiolation
GIS01_20290	COG2923	Belongs to the DsrF TusC family
GIS01_20295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GIS01_20305	COG2964	Protein conserved in bacteria
GIS01_20310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GIS01_20315	COG0085	RNA polymerase activity
GIS01_20320	COG0222	ribosome binding
GIS01_20325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GIS01_20330	COG0081	regulation of translation
GIS01_20335	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GIS01_20340	COG0250	Participates in transcription elongation, termination and antitermination
GIS01_20345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GIS01_20355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GIS01_20380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GIS01_20385	COG0569	domain protein
GIS01_20390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_20420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GIS01_20420	COG4191	Histidine kinase
GIS01_20425	COG3005	denitrification pathway
GIS01_20430	COG0243	molybdopterin cofactor binding
GIS01_20440	COG2205	protein histidine kinase activity
GIS01_20445	COG0745	RESPONSE REGULATOR receiver
GIS01_20480	COG2204	response regulator
GIS01_20490	COG2205	protein histidine kinase activity
GIS01_20505	COG1028	Short-chain dehydrogenase reductase Sdr
GIS01_20510	COG0517	IMP dehydrogenase activity
GIS01_20510	COG0516	GMP reductase activity
GIS01_20515	COG5413	integral membrane protein
GIS01_20525	COG1522	sequence-specific DNA binding
GIS01_20530	COG2502	aspartate--ammonia ligase
GIS01_20535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GIS01_20540	COG0542	response to heat
GIS01_20550	COG0564	pseudouridine synthase activity
GIS01_20555	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GIS01_20560	COG0446	pyridine nucleotide-disulphide oxidoreductase
GIS01_20570	COG3681	Belongs to the UPF0597 family
GIS01_20575	COG2964	Protein conserved in bacteria
GIS01_20585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GIS01_20590	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GIS01_20595	COG1979	alcohol dehydrogenase
GIS01_20600	COG2207	Transcriptional regulator
GIS01_20605	COG3040	lipid binding
GIS01_20620	COG0583	DNA-binding transcription factor activity
GIS01_20640	COG0540	Belongs to the ATCase OTCase family
GIS01_20645	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GIS01_20650	COG1438	arginine binding
GIS01_20655	COG1288	antiporter activity
GIS01_20660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GIS01_20685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GIS01_20695	COG3078	GTPase activator activity
GIS01_20705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GIS01_20715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GIS01_20720	COG0408	coproporphyrinogen oxidase activity
GIS01_20725	COG0009	L-threonylcarbamoyladenylate synthase
GIS01_20735	COG0551	DNA topoisomerase type I activity
GIS01_20740	COG2922	Belongs to the Smg family
GIS01_20745	COG0758	DNA mediated transformation
GIS01_20750	COG1652	LysM domain
GIS01_20755	COG0242	peptide deformylase activity
GIS01_20760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GIS01_20765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GIS01_20765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GIS01_20770	COG0569	domain protein
GIS01_20775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_20785	COG0174	glutamine synthetase
GIS01_20795	COG3852	Histidine kinase
GIS01_20800	COG2204	response regulator
GIS01_20805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GIS01_20815	COG1322	Protein conserved in bacteria
GIS01_20835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GIS01_20840	COG0583	DNA-binding transcription factor activity
GIS01_20845	COG0519	Catalyzes the synthesis of GMP from XMP
GIS01_20845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GIS01_20860	COG1396	sequence-specific DNA binding
GIS01_20865	COG1012	belongs to the aldehyde dehydrogenase family
GIS01_20875	COG2962	Rard protein
GIS01_20885	COG2391	methyltransferase activity
GIS01_20900	COG0129	dihydroxy-acid dehydratase activity
GIS01_20905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GIS01_20910	COG3978	acetolactate synthase activity
GIS01_20925	COG0606	chelatase, subunit chli
GIS01_20930	COG0204	Acyl-transferase
GIS01_20935	COG0204	Acyl-transferase
GIS01_20940	COG1683	Conserved Protein
GIS01_20950	COG1335	isochorismatase
GIS01_20960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GIS01_20965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GIS01_20975	COG3084	Protein conserved in bacteria
GIS01_20980	COG5001	Diguanylate cyclase
GIS01_20980	COG4251	negative regulation of phosphorylation
GIS01_20980	COG3706	GGDEF domain
GIS01_20980	COG2203	Gaf domain
GIS01_20995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GIS01_21000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GIS01_21005	COG1561	YicC-like family, N-terminal region
GIS01_21010	COG0583	DNA-binding transcription factor activity
GIS01_21035	COG0385	Bile acid
GIS01_21040	COG0531	amino acid
GIS01_21045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GIS01_21050	COG0531	amino acid
GIS01_21055	COG2731	YhcH YjgK YiaL family protein
GIS01_21060	COG3250	beta-galactosidase activity
GIS01_21065	COG1609	Transcriptional regulator
GIS01_21100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GIS01_21105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_21105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GIS01_21110	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GIS01_21115	COG3074	FtsZ-dependent cytokinesis
GIS01_21125	COG1045	serine acetyltransferase
GIS01_21135	COG0745	RESPONSE REGULATOR receiver
GIS01_21140	COG2205	protein histidine kinase activity
GIS01_21145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GIS01_21150	COG0534	Mate efflux family protein
GIS01_21165	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GIS01_21170	COG2937	Belongs to the GPAT DAPAT family
GIS01_21175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GIS01_21180	COG3161	chorismate lyase activity
GIS01_21205	COG0604	alcohol dehydrogenase
GIS01_21210	COG1519	Transferase
GIS01_21215	COG0859	PFAM glycosyl transferase family 9
GIS01_21220	COG0463	Glycosyl transferase, family 2
GIS01_21225	COG0859	PFAM glycosyl transferase family 9
GIS01_21230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GIS01_21235	COG2990	Protein conserved in bacteria
GIS01_21240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GIS01_21250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GIS01_21255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GIS01_21260	COG2003	Belongs to the UPF0758 family
GIS01_21265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GIS01_21275	COG4974	Belongs to the 'phage' integrase family
GIS01_21315	COG2916	Histone family protein nucleoid-structuring protein H-NS
GIS01_21345	COG0756	dUTP diphosphatase activity
GIS01_21355	COG1309	transcriptional regulator
GIS01_21360	COG0668	transmembrane transport
GIS01_21365	COG0166	Belongs to the GPI family
GIS01_21370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GIS01_21375	COG0583	DNA-binding transcription factor activity
GIS01_21390	COG1042	CoA-binding domain protein
GIS01_21390	COG0045	succinate-CoA ligase (ADP-forming) activity
GIS01_21390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GIS01_21420	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GIS01_21425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GIS01_21430	COG1739	Uncharacterized protein family UPF0029
GIS01_21435	COG0006	proline dipeptidase activity
GIS01_21440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GIS01_21445	COG1024	Enoyl-CoA hydratase
GIS01_21445	COG1250	3-hydroxyacyl-CoA dehydrogenase
GIS01_21450	COG0183	Belongs to the thiolase family
GIS01_21455	COG0745	RESPONSE REGULATOR receiver
GIS01_21460	COG2205	protein histidine kinase activity
GIS01_21475	COG0425	Belongs to the sulfur carrier protein TusA family
GIS01_21480	COG0251	oxidation-reduction process
GIS01_21490	COG2885	chlorophyll binding
GIS01_21495	COG2818	Glycosylase
GIS01_21500	COG0752	glycyl-tRNA synthetase alpha subunit
GIS01_21505	COG0751	glycine-tRNA ligase activity
GIS01_21520	COG2202	Pas domain
GIS01_21520	COG2200	EAL domain
GIS01_21520	COG2199	diguanylate cyclase activity
GIS01_21545	COG1609	Transcriptional regulator
GIS01_21555	COG0559	Belongs to the binding-protein-dependent transport system permease family
GIS01_21575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GIS01_21590	COG2960	long-chain fatty acid transporting porin activity
GIS01_21595	COG5001	Diguanylate cyclase
GIS01_21605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GIS01_21615	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GIS01_21620	COG3118	belongs to the thioredoxin family
GIS01_21625	COG0513	Belongs to the DEAD box helicase family
GIS01_21630	COG0248	Ppx GppA phosphatase
GIS01_21640	COG0742	ribosomal rna small subunit methyltransferase
GIS01_21655	COG3469	chitinase activity
GIS01_21660	COG3397	chitin binding
GIS01_21670	COG0084	hydrolase, TatD family'
GIS01_21675	COG0805	protein transport
GIS01_21680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_21685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GIS01_21690	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GIS01_21695	COG3165	ubiquinone biosynthetic process from chorismate
GIS01_21700	COG2226	methyltransferase
GIS01_21705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GIS01_21710	COG0402	S-adenosylhomocysteine deaminase activity
GIS01_21715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GIS01_21755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GIS01_21760	COG0848	biopolymer transport protein
GIS01_21765	COG0811	peptide transport
GIS01_21770	COG0811	peptide transport
GIS01_21780	COG2771	luxR family
GIS01_21785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GIS01_21790	COG1349	DNA-binding transcription factor activity
GIS01_21795	COG0745	RESPONSE REGULATOR receiver
GIS01_21800	COG2205	protein histidine kinase activity
GIS01_21815	COG4452	Inner membrane protein CreD
GIS01_21820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GIS01_21825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GIS01_21830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GIS01_21835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GIS01_21840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GIS01_21845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GIS01_21850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GIS01_21860	COG0356	it plays a direct role in the translocation of protons across the membrane
GIS01_21870	COG1475	DNA binding
GIS01_21875	COG1192	Involved in chromosome partitioning
GIS01_21880	COG0357	Ribosomal RNA small subunit methyltransferase G
GIS01_21885	COG0445	tRNA wobble uridine modification
GIS01_21890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GIS01_21900	COG4615	Cyclic peptide transporter
GIS01_21905	COG1120	ATPase activity
GIS01_21910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GIS01_21920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GIS01_21925	COG0706	membrane insertase activity
GIS01_21930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GIS01_21935	COG0594	ribonuclease P activity
GIS01_21940	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GIS01_21965	COG2026	Addiction module toxin, RelE StbE family
GIS01_22005	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GIS01_22060	COG1192	Involved in chromosome partitioning
GIS01_22080	COG1609	Transcriptional regulator