locus-tag class description WM43_00005 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) WM43_00010 ENOG4105VRT cytoplasmic protein WM43_00015 ENOG4108WBT adenosyltransferase WM43_00025 ENOG4107S6Z Na H antiporter WM43_00030 ENOG4107104 thymidine kinase WM43_00040 ENOG4108RMJ sensory transduction regulator WM43_00075 ENOG4107QMH DNA methylase WM43_00135 ENOG4108YGG dna repair protein WM43_00210 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) WM43_00215 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) WM43_00220 ENOG4108JQ2 peptide transport system atp-binding protein WM43_00225 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein WM43_00230 ENOG4108EU3 peptide transport system, permease WM43_00235 ENOG4108I5W peptide transport system, permease protein WM43_00240 ENOG4105DEF Extracellular solute-binding protein, family 5 WM43_00245 ENOG4105E51 psp operon transcriptional activator WM43_00250 ENOG41087YS Phage shock protein A WM43_00255 ENOG4105YYT phage shock protein B WM43_00265 ENOG4105CM6 amino acid regulated cytosolic protein WM43_00270 ENOG4106K28 UPF0283 membrane protein WM43_00275 ENOG4108M0I Transcriptional regulator WM43_00280 ENOG4107TYH extracellular solute-binding protein family 1 WM43_00285 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WM43_00290 ENOG4105D81 ABC transporter, permease WM43_00295 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component WM43_00300 ENOG4105C26 Dehydrogenase WM43_00310 ENOG41090A4 Pterin carbinolamine dehydratase WM43_00325 ENOG4108KHX Diguanylate cyclase WM43_00330 ENOG41090EK ompa motb domain protein WM43_00335 ENOG4105EE5 Membrane protein terC WM43_00345 ENOG4105MH2 YfcL protein WM43_00355 ENOG4105C28 cystathionine WM43_00365 ENOG4108RYK Nad-dependent epimerase dehydratase WM43_00370 ENOG4105CR8 Transcriptional regulator WM43_00375 ENOG41064T2 transcriptional regulator, lysR family WM43_00380 ENOG4105DJB Major Facilitator Superfamily WM43_00385 ENOG4105EUB pirin domain protein WM43_00390 ENOG4105CHJ isochorismatase hydrolase WM43_00395 ENOG4105EXG Transcriptional regulator WM43_00400 ENOG4105DZ2 Transcriptional regulator WM43_00405 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) WM43_00415 ENOG4108KB2 LysR family Transcriptional regulator WM43_00420 ENOG4105CS2 ec 3.2.1.21 WM43_00425 ENOG4105DDY UPF0142 protein ycaO WM43_00430 ENOG4105TMB Formate nitrite transporter WM43_00435 ENOG4105C6N Formate acetyltransferase WM43_00460 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) WM43_00465 ENOG4105C8P )-transporter WM43_00470 ENOG4105K63 Thioredoxin WM43_00475 ENOG4105BZU Histidine kinase WM43_00480 ENOG4105BZ1 (ABC) transporter WM43_00485 ENOG4105BZ1 (ABC) transporter WM43_00495 ENOG4105WQ3 Rna-binding protein WM43_00510 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) WM43_00535 ENOG4105K5X acetyltransferase WM43_00545 ENOG4105BZN citrate synthase WM43_00550 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit WM43_00555 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein WM43_00560 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) WM43_00565 ENOG4105E33 succinate dehydrogenase WM43_00570 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 WM43_00575 ENOG4105C7S Dehydrogenase WM43_00580 ENOG4105CMV Succinyl-CoA synthetase subunit beta WM43_00585 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha WM43_00600 ENOG4106HK8 GPR1 FUN34 yaaH family protein WM43_00620 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase WM43_00630 ENOG4105E39 Enoyl-CoA hydratase WM43_00635 ENOG4107QX3 carboxylase WM43_00640 ENOG4105C1G acyl-Coa dehydrogenase WM43_00645 ENOG4105C1G acyl-Coa dehydrogenase WM43_00650 ENOG4105E39 Enoyl-CoA hydratase WM43_00655 ENOG4105E39 Enoyl-CoA hydratase WM43_00660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase WM43_00665 ENOG4105CHR reductase WM43_00670 ENOG4105D5Q Arginine ornithine antiporter WM43_00675 ENOG4105HF0 Membrane WM43_00705 ENOG4105BZU Histidine kinase WM43_00735 ENOG4105F8J Adenylate Guanylate cyclase WM43_00740 ENOG4105CG5 Glycosyl transferase (Group 1 WM43_00750 ENOG4107QZ7 Cellulose synthase catalytic subunit WM43_00755 ENOG4108KMV Glycosyl transferase (Group 1 WM43_00810 ENOG4107EF8 Glycosyl transferase (Group 1 WM43_00835 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) WM43_00845 ENOG4105E3S small subunit WM43_00850 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein WM43_00855 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit WM43_00860 ENOG4105DPX Hydrogenase, large subunit WM43_00865 ENOG4108USZ hydrogenase WM43_00870 ENOG4108WGS hydrogenase 2-specific chaperone WM43_00880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WM43_00885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WM43_00895 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WM43_00900 ENOG4107RSS Hydrogenase accessory protein HypB WM43_00905 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) WM43_00910 ENOG4105C45 hydrogenase expression formation protein (HypE) WM43_00915 ENOG4105CQS hydrogenase expression formation protein HypD WM43_00920 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF WM43_00930 ENOG4105EM7 Selenocysteine-specific translation elongation factor WM43_00950 ENOG4108MG9 hydrogenase 3 maturation protease WM43_00955 ENOG4105I6X formate hydrogenlyase maturation WM43_00960 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit WM43_00970 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_00975 ENOG4107TDF Formate hydrogenlyase subunit 4 WM43_00980 ENOG4108JPZ Monovalent cation H antiporter subunit D WM43_00985 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) WM43_00990 ENOG4105DFH Transport of potassium into the cell (By similarity) WM43_01005 ENOG4108RC0 Electron transport protein WM43_01010 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) WM43_01015 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) WM43_01030 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WM43_01035 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WM43_01040 ENOG4105MWK D-amino acid dehydrogenase, small subunit WM43_01045 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein WM43_01050 ENOG4105C0F tryptophanase EC 4.1.99.1 WM43_01055 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) WM43_01060 ENOG41067MG lrgb family WM43_01070 ENOG4107R49 K07407 alpha-galactosidase EC 3.2.1.22 WM43_01080 ENOG4105CJB Exodeoxyribonuclease I WM43_01100 ENOG410600T transposase WM43_01110 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) WM43_01135 ENOG410890F Dynamin family WM43_01140 ENOG4105F5W AtP-binding protein WM43_01145 ENOG4105D70 Integrase catalytic subunit WM43_01200 ENOG4105C4X radical SAM domain protein WM43_01225 ENOG4107QVM von Willebrand factor, type A WM43_01245 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WM43_01250 ENOG4105ENH Sulfatase WM43_01255 ENOG4105DHT Metal Dependent Phosphohydrolase WM43_01265 ENOG4105CQ7 ATP-dependent helicase WM43_01275 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) WM43_01285 ENOG4105CHU acetyl-coa acetyltransferase WM43_01290 ENOG4105D58 Diguanylate phosphodiesterase WM43_01295 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation WM43_01300 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation WM43_01310 ENOG4105EMN RNA polymerase sigma factor WM43_01340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WM43_01345 ENOG4105CHU acetyl-coa acetyltransferase WM43_01350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WM43_01355 ENOG4105ED1 spovr family WM43_01360 ENOG4106AKX UPF0229 protein WM43_01365 ENOG4105CYN Serine protein kinase WM43_01370 ENOG4105C9U ATP-dependent DNA helicase RecQ WM43_01375 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) WM43_01380 ENOG4105C44 Serine transporter WM43_01385 ENOG4105P8F nudix hydrolase WM43_01400 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA WM43_01420 ENOG4105CVJ phosphoglycerate mutase WM43_01425 ENOG4105BZU Histidine kinase WM43_01430 ENOG4108DG9 Smr protein MutS2 WM43_01435 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) WM43_01440 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase WM43_01450 ENOG4105C1J atp-dependent rna helicase WM43_01460 ENOG4105WJG Glutathione WM43_01470 ENOG4105E0U tyrosine-specific transport protein WM43_01475 ENOG4107B7Y DNA-binding transcriptional regulator FruR WM43_01480 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein WM43_01485 ENOG4105DE4 1-phosphofructokinase WM43_01490 ENOG4105DM4 PTS System WM43_01495 ENOG4105C03 ribonuclease WM43_01500 ENOG4105EI2 Pseudouridine synthase WM43_01510 ENOG4108UHJ MAF-like protein WM43_01515 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein WM43_01520 ENOG4105VGS 50s ribosomal protein l32 WM43_01525 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) WM43_01530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WM43_01535 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase WM43_01540 ENOG4105CHR reductase WM43_01545 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) WM43_01550 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WM43_01555 ENOG4105YAZ 4-amino-4-deoxychorismate lyase WM43_01560 ENOG4105HHA aminodeoxychorismate lyase WM43_01565 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) WM43_01570 ENOG4107QRG dna polymerase iii WM43_01575 ENOG4105F8V Hydrolase, tatD family WM43_01590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WM43_01595 ENOG4105DY2 Paraquat-inducible protein b WM43_01600 ENOG4105F1S paraquat-inducible protein a WM43_01610 ENOG4105CR4 methylisocitrate lyase WM43_01615 ENOG4105BZN citrate synthase WM43_01620 ENOG4105DXD 2-methylcitrate dehydratase WM43_01660 ENOG410600T transposase WM43_01665 ENOG4105PDP Short chain dehydrogenase WM43_01670 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold WM43_01675 ENOG4105X2V dna damage-inducible protein WM43_01695 ENOG4105DAN ATP-dependent protease WM43_01700 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) WM43_01705 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) WM43_01710 ENOG4105C5H ABC transporter WM43_01720 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) WM43_01730 ENOG4105NRA 50s ribosomal protein l31 type b WM43_01740 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) WM43_01745 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) WM43_01750 ENOG4105C7I Dehydrogenase WM43_01760 ENOG4105CD8 aminopeptidase N WM43_01765 ENOG4105CN1 protease WM43_01770 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) WM43_01775 ENOG4108ZGC gaf domain protein WM43_01785 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i WM43_01800 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) WM43_01810 ENOG4105C59 p-type ATPase WM43_01825 ENOG4105DS0 Transcriptional regulator, Crp Fnr family WM43_01830 ENOG4105Q9Y Universal stress protein WM43_01835 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) WM43_01855 ENOG4105F38 ABC transporter, permease WM43_01860 ENOG4105D38 putrescine abc transporter WM43_01865 ENOG4107RUE extracellular solute-binding protein family 1 WM43_01875 ENOG4108RXX maleylacetoacetate isomerase WM43_01880 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) WM43_01885 ENOG4105C2J ABC transporter WM43_01890 ENOG4105CNN ABC, transporter WM43_01895 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator WM43_01900 ENOG4108RVA ribokinase WM43_01905 ENOG4105ETE Transcriptional regulator (LacI family WM43_01910 ENOG4105BZU Histidine kinase WM43_01920 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) WM43_01935 ENOG4105BZU Histidine kinase WM43_01940 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WM43_01945 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) WM43_01950 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) WM43_01955 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) WM43_01965 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) WM43_01970 ENOG4105C22 threonyL-tRNA synthetase WM43_01990 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WM43_01995 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) WM43_02000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WM43_02005 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WM43_02010 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WM43_02015 ENOG4105XPH Ferredoxin WM43_02020 ENOG4105CA3 membrane-bound lytic murein transglycosylase WM43_02025 ENOG4105XZD Fe-S protein WM43_02030 ENOG4107SZR mannose-6-phosphate isomerase WM43_02035 ENOG4105F3R pts system mannose fructose sorbose family iid WM43_02040 ENOG4105ETZ PTS System WM43_02045 ENOG4108EQA pts system WM43_02060 ENOG4107P2S Transcriptional regulator WM43_02065 ENOG4108Y83 glucose-6-phosphate isomerase WM43_02070 ENOG4105CJ3 phosphate transporter WM43_02075 ENOG4105DHP deoxycytidine triphosphate deaminase WM43_02080 ENOG4105DBI uridine monophosphokinase WM43_02085 ENOG4105D1F ATP-binding protein WM43_02090 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) WM43_02100 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 WM43_02105 ENOG4108NVR Methyl-accepting chemotaxis WM43_02110 ENOG4105I03 Flagellin WM43_02115 ENOG4105DR4 Methyltransferase WM43_02120 ENOG4105FAT Acyl-transferase WM43_02130 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) WM43_02135 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) WM43_02140 ENOG4105C5X domain protein WM43_02155 ENOG4105CEY Amp-dependent synthetase and ligase WM43_02160 ENOG4108MXF Alpha Beta Hydrolase WM43_02170 ENOG41072GX Peptidase M22 Glycoprotease WM43_02175 ENOG4105DVT helicase WM43_02185 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) WM43_02195 ENOG4105CIH Imidazole acetol-phosphate transaminase WM43_02200 ENOG4105ECC imidazole-glycerol-phosphate dehydratase WM43_02205 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) WM43_02210 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase WM43_02215 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) WM43_02220 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase WM43_02230 ENOG4105BZU Histidine kinase WM43_02235 ENOG4105CEY Amp-dependent synthetase and ligase WM43_02240 ENOG4105CSX c4-dicarboxylate anaerobic carrier WM43_02255 ENOG4107MBR 17 kDa surface antigen WM43_02260 ENOG4108UTP (2Fe-2S)-binding domain protein WM43_02265 ENOG4108HR6 Dehydrogenase WM43_02270 ENOG4105C7W Xanthine dehydrogenase WM43_02275 ENOG4105C7N Xanthine uracil vitamin C permease WM43_02280 ENOG4107QUY Guanine deaminase WM43_02285 ENOG4105C2W permease WM43_02290 ENOG4105C7W Xanthine dehydrogenase WM43_02295 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase WM43_02300 ENOG4107UUR Chlorohydrolase aminohydrolase WM43_02305 ENOG4105BZ8 glutamate synthase WM43_02310 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase WM43_02315 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC WM43_02320 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family WM43_02325 ENOG4108Q5Y Membrane WM43_02330 ENOG4105S10 periplasmic binding protein WM43_02335 ENOG4105EHG Permease protein WM43_02350 ENOG4105C5B carbamate kinase WM43_02360 ENOG4107S4Y M20 DapE family protein YgeY WM43_02365 ENOG4107RCH Diaminopropionate ammonia-lyase WM43_02370 ENOG4105IW6 Carbamoyltransferase WM43_02400 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WM43_02410 ENOG4108Z0Z intracellular protease Pfpi family WM43_02425 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) WM43_02430 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) WM43_02435 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) WM43_02440 ENOG4106371 Methyltransferase WM43_02445 ENOG4107S90 membrAne WM43_02455 ENOG4105CTQ phosphohexokinase WM43_02465 ENOG4105NBK UPF0345 protein WM43_02470 ENOG4105EJQ L-serine dehydratase WM43_02475 ENOG4105EJQ L-serine dehydratase WM43_02480 ENOG4105VNG YcgL domain-containing protein WM43_02485 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) WM43_02490 ENOG4107QMS site-determining protein WM43_02495 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) WM43_02505 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase WM43_02510 ENOG4105XW2 UPF0263 protein WM43_02545 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) WM43_02550 ENOG4108SXK Transporter Drug Metabolite Exporter family WM43_02555 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR WM43_02560 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 WM43_02570 ENOG4108R6K riboflavin synthase, subunit alpha WM43_02580 ENOG4105W1I UPF0253 protein WM43_02585 ENOG4107QI1 Mate efflux family protein WM43_02615 ENOG4108JUB Transcriptional regulator WM43_02630 ENOG4108VWS Yaeq family WM43_02640 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WM43_02645 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) WM43_02650 ENOG4105DQR SNARE associated Golgi WM43_02660 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) WM43_02670 ENOG4105D0C transport protein WM43_02675 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) WM43_02680 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) WM43_02695 ENOG4105CEE C4-dicarboxylate transporter WM43_02710 ENOG4108VKG metal-dependent hydrolase WM43_02725 ENOG4105CQ2 DNA polymerase WM43_02735 ENOG4105BZU Histidine kinase WM43_02750 ENOG4105D1S lipid A biosynthesis WM43_02755 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase WM43_02765 ENOG4105DUM transcriptional regulator, lysR family WM43_02770 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) WM43_02775 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) WM43_02780 ENOG4107QMP dna polymerase iii subunits gamma and tau WM43_02785 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) WM43_02790 ENOG4105WD1 Membrane WM43_02795 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) WM43_02810 ENOG4105PAD Hydrolase WM43_02815 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WM43_02865 ENOG4105CPB ATP-dependent endonuclease of the OLD family WM43_02880 ENOG4105VP0 transcriptional regulator, lysR family WM43_02885 ENOG4105EJ9 Membrane WM43_02890 ENOG4106IUH DTW domain containing protein WM43_02895 ENOG4105E2R ROK family WM43_02900 ENOG4105C8Q Methyl-accepting chemotaxis WM43_02905 ENOG4105K5B UPF0225 protein WM43_02910 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A WM43_02915 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B WM43_02920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) WM43_02935 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit WM43_02940 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein WM43_02945 ENOG4105DVI reductase, NrfD WM43_02950 ENOG4105DA4 cytochrome c-type biogenesis protein WM43_02955 ENOG4107QX9 Thiol disulfide interChange protein WM43_02960 ENOG4108DMF Cytochrome C biogenesis protein WM43_02975 ENOG4108KAZ Involved in phosphonate degradation (By similarity) WM43_02980 ENOG4108JPW Aminotransferase WM43_02985 ENOG4107STF Involved in phosphonate degradation (By similarity) WM43_02995 ENOG4105C4Y ABC transporter WM43_03005 ENOG4107RCV ABC transporter, permease WM43_03010 ENOG4105CJP fad dependent oxidoreductase WM43_03030 ENOG4105BZG amino acid carrier protein WM43_03065 ENOG41060WC Enoyl-CoA hydratase WM43_03080 ENOG41062QD Membrane WM43_03085 ENOG4107QN1 sodium solute WM43_03090 ENOG4105C5H ABC transporter WM43_03095 ENOG4105EIN peptidylprolyl cis-trans isomerase WM43_03100 ENOG4105K70 DNA-binding protein WM43_03105 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) WM43_03110 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) WM43_03115 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) WM43_03120 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation WM43_03135 ENOG4105D60 lipoprotein releasing system transmembrane protein WM43_03140 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WM43_03145 ENOG4105D60 lipoprotein releasing system transmembrane protein WM43_03155 ENOG4108JA2 transcriptioN-repair coupling factor WM43_03160 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 WM43_03165 ENOG4108J59 Extracellular solute-binding protein, family 5 WM43_03170 ENOG4108IPJ Membrane WM43_03180 ENOG4108BY2 phosphohistidine phosphatase WM43_03185 ENOG4107QXK peptidase WM43_03190 ENOG4105FQ6 thiopurine methyltransferase WM43_03200 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WM43_03205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WM43_03215 ENOG4105DB4 WM43_03225 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WM43_03230 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WM43_03235 ENOG4105DS1 cytochrome b561 WM43_03245 ENOG4105FDP GntR family transcriptional regulator WM43_03250 ENOG4105DM4 PTS System WM43_03255 ENOG4105C8I hydrolase, family 38 WM43_03260 ENOG4105CPF Cell wall formation (By similarity) WM43_03270 ENOG4108V06 Glutathione peroxidase WM43_03275 ENOG4105C1J atp-dependent rna helicase WM43_03280 ENOG4105D4P Coproporphyrinogen iii oxidase WM43_03285 ENOG4108NVR Methyl-accepting chemotaxis WM43_03290 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WM43_03295 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase WM43_03300 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) WM43_03305 ENOG4105C10 Electron transfer flavoprotein WM43_03310 ENOG4105BZJ Electron transfer flavoprotein WM43_03315 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase WM43_03320 ENOG4107QUT magnesium and cobalt transport protein CorA WM43_03325 ENOG4105QZU Inner membrane protein YfeZ WM43_03335 ENOG4105F3T (LipO)protein WM43_03350 ENOG4105BZU Histidine kinase WM43_03365 ENOG4107RE1 Inosine-guanosine kinase WM43_03375 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) WM43_03380 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) WM43_03385 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase WM43_03390 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase WM43_03395 ENOG4105E96 Colicin v production protein WM43_03400 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) WM43_03405 ENOG4105D1H recombination factor protein RarA WM43_03410 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) WM43_03415 ENOG4105CNU cell division protein FtsK WM43_03420 ENOG4105EW9 transcriptional regulator AsnC family WM43_03425 ENOG4105DCF alanine dehydrogenase WM43_03430 ENOG4105C3M thioredoxin reductase WM43_03435 ENOG4105BZU Histidine kinase WM43_03440 ENOG4107MBR 17 kDa surface antigen WM43_03445 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) WM43_03450 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate WM43_03455 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) WM43_03460 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WM43_03465 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) WM43_03470 ENOG4105VEQ Cold shock protein WM43_03475 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) WM43_03525 ENOG410600T transposase WM43_03530 ENOG410600T transposase WM43_03545 ENOG410600T transposase WM43_03555 ENOG410600T transposase WM43_03560 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WM43_03575 ENOG4108UTZ Dihydroxyacetone kinase WM43_03580 ENOG4105CMT Dihydroxyacetone kinase WM43_03585 ENOG4105C7N Xanthine uracil vitamin C permease WM43_03635 ENOG4105P8Q Curli production assembly transport component CsgG WM43_03645 ENOG4108XDW curli assembly protein CsgE WM43_03650 ENOG41086KC Transcriptional regulator WM43_03670 ENOG4105F2I Transposase WM43_03745 ENOG4105CAF HipA N-terminal domain protein WM43_03760 ENOG4107EXC regulatoR WM43_03765 ENOG4105JJR Histidine kinase WM43_03775 ENOG4105FF5 Membrane WM43_03800 ENOG4106RHG Yeca family WM43_03805 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) WM43_03815 ENOG4105DZR Type I site-specific deoxyribonuclease WM43_03830 ENOG4105F2I Transposase WM43_03855 ENOG4105BZU Histidine kinase WM43_03895 ENOG4105CHH sulfate transporter WM43_03910 ENOG4105DFP Integrase WM43_03940 ENOG410600T transposase WM43_04010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WM43_04035 ENOG4105C3J Cysteine desulfurase WM43_04080 ENOG4105C2C drug resistance transporter, Bcr CflA WM43_04095 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) WM43_04120 ENOG4105F2Z 3-oxoadipate enol-lactonase WM43_04140 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) WM43_04145 ENOG4107QZM n-acetylglutamate synthase WM43_04150 ENOG4105CFH Aspartokinase WM43_04160 ENOG4107T7U Sulfatase WM43_04165 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A WM43_04170 ENOG4108NRW Phospholipase, patatin family WM43_04175 ENOG4105D5B Sulfite reductase, subunit A WM43_04180 ENOG4107SHJ sulfite reductase subunit b WM43_04185 ENOG410810Y Sulfite reductase WM43_04190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WM43_04200 ENOG4105K8R UPF0145 protein WM43_04205 ENOG4108S3P Sporulation domain protein WM43_04210 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase WM43_04215 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) WM43_04220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) WM43_04230 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) WM43_04240 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) WM43_04245 ENOG4105EYK Phosphatidylglycerophosphatase B WM43_04250 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) WM43_04255 ENOG4105D3Y Na H antiporter WM43_04260 ENOG4105BZU Histidine kinase WM43_04275 ENOG4105KA0 thioesterase Superfamily protein WM43_04285 ENOG4105CQB FAD linked oxidase domain protein WM43_04295 ENOG4105EE5 Membrane protein terC WM43_04300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WM43_04310 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WM43_04315 ENOG4105D4U had-superfamily hydrolase, subfamily iia WM43_04320 ENOG4105CKD glutathione-regulated potassium-efflux system protein WM43_04330 ENOG4105CAQ asparagine synthetase WM43_04360 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) WM43_04365 ENOG4105WH1 Two component transcriptional regulator luxr family WM43_04370 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) WM43_04375 ENOG4105W49 UPF0434 protein WM43_04380 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) WM43_04390 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 WM43_04405 ENOG4105CGF Aromatic amino acid aminotransferase WM43_04415 ENOG4105CVI Transcriptional regulator WM43_04420 ENOG4108WFC UPF0438 protein yifE WM43_04425 ENOG4108QSZ General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity) WM43_04430 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase WM43_04435 ENOG4105C6V Glycerol-3-phosphate dehydrogenase WM43_04440 ENOG4105E98 transcriptional regulator DeoR family WM43_04445 ENOG4105CXY transporter WM43_04450 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WM43_04455 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) WM43_04470 ENOG4105HEI LysR family (Transcriptional regulator WM43_04490 ENOG4105CV8 reductase WM43_04500 ENOG4105F27 Major Facilitator WM43_04505 ENOG4108X0B nad(p)h dehydrogenase (quinone) WM43_04520 ENOG4105E18 UPF0276 protein WM43_04540 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WM43_04545 ENOG4105C4M (Ubiquinol oxidase) subunit I WM43_04550 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WM43_04560 ENOG4108Q2J Inner membrane protein YebE WM43_04565 ENOG4105NAU thioesterase Superfamily protein WM43_04575 ENOG4105DJ2 Major Facilitator Superfamily WM43_04580 ENOG4105FE9 pseudouridine synthase WM43_04590 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) WM43_04625 ENOG4105DGN Electron transport complex WM43_04630 ENOG4108R3D Electron transport complex WM43_04640 ENOG4105D6A Electron transport complex WM43_04650 ENOG4105DZB Electron transport complex WM43_04655 ENOG4105CSM endonuclease III WM43_04660 ENOG4108UYE Lactoylglutathione lyase WM43_04665 ENOG4105EIY sodium-type flagellar protein motY WM43_04690 ENOG4108J1Q WM43_04700 ENOG410600T transposase WM43_04710 ENOG4105DVT helicase WM43_04720 ENOG4105DGU Histone deacetylase WM43_04725 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) WM43_04730 ENOG4105G6Z alkaline phosphatase WM43_04750 ENOG4105NXH GreA GreB family elongation factor WM43_04755 ENOG4108KX4 response regulator WM43_04760 ENOG4105BZU Histidine kinase WM43_04765 ENOG4105CXY transporter WM43_04770 ENOG4105BZU Histidine kinase WM43_04775 ENOG4106PMH Extracellular solute-binding protein family 3 WM43_04780 ENOG4105E5Q amino acid AbC transporter WM43_04785 ENOG4105CDA abc transporter atp-binding protein WM43_04800 ENOG4105D5Q Arginine ornithine antiporter WM43_04805 ENOG4105C3R Methionine synthase WM43_04815 ENOG4105C37 (CBS) domain WM43_04825 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) WM43_04830 ENOG4105E2Z phosphate ABC transporter (Permease WM43_04835 ENOG4105C8U phosphate abc transporter WM43_04840 ENOG4108Z6B deaminase WM43_04850 ENOG4107QP3 malate synthase g WM43_04855 ENOG4108I9X Isocitrate lyase WM43_04870 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) WM43_04875 ENOG4105CXB phosphoribosylaminoimidazole synthetase WM43_04880 ENOG4108V3E phosphoribosylglycinamide formyltransferase WM43_04885 ENOG4107QNR UPF0135 protein WM43_04890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_04895 ENOG4105BZU Histidine kinase WM43_04900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_04910 ENOG4105RH4 Glycine cleavage system transcriptional repressor WM43_04915 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) WM43_04920 ENOG4105C9X ppx gppa phosphatase WM43_04925 ENOG4105CJW magnesium transporter WM43_04930 ENOG4105DTJ flagellar hook-associated protein WM43_04940 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj WM43_04945 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WM43_04950 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) WM43_04955 ENOG4105CGA flagellar basal-body rod protein FlgG WM43_04960 ENOG4108KPB Flagellar basal-body rod protein FlgF WM43_04965 ENOG4105BZE flagellar hook protein, FlgE WM43_04975 ENOG4108ZC9 flagellar basal-body rod protein flgc WM43_04980 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) WM43_04985 ENOG4105BZU Histidine kinase WM43_04990 ENOG4107R88 Chemotaxis protein (CheV) WM43_04995 ENOG4107ESN Flagella basal body P-ring formation protein flgA WM43_05010 ENOG4108RE9 Phosphodiesterase WM43_05015 ENOG4107QSI ABC, transporter WM43_05025 ENOG4105I08 Pseudouridine synthase WM43_05030 ENOG4105DHT Metal Dependent Phosphohydrolase WM43_05040 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WM43_05045 ENOG4105F1A Pyruvate formate-lyase WM43_05050 ENOG4105C6N Formate acetyltransferase WM43_05055 ENOG4105N2W Transcriptional regulator WM43_05060 ENOG4105E43 Extracellular solute-binding protein, family 5 WM43_05085 ENOG4105VEQ Cold shock protein WM43_05090 ENOG4107QSN dihydrolipoamide acetyltransferase WM43_05095 ENOG4105CPP Dehydrogenase, E1 component WM43_05100 ENOG4107RUY (E1 component), alpha subunit WM43_05110 ENOG4105C0W non-ribosomal peptide synthetase WM43_05115 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase WM43_05120 ENOG4105WQI isochorismatase WM43_05125 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase WM43_05130 ENOG4105E4F Isochorismate synthase WM43_05135 ENOG4105D05 Receptor WM43_05140 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WM43_05145 ENOG41060NJ transcriptional regulator WM43_05150 ENOG4107SC1 transglycosylase WM43_05155 ENOG4105BZU Histidine kinase WM43_05160 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA WM43_05180 ENOG4105MA0 exported protein WM43_05185 ENOG4105CFU surface antigen WM43_05195 ENOG4105KQ5 peptidylprolyl cis-trans isomerase WM43_05210 ENOG4108MVM Transposase WM43_05215 ENOG4108ZQS transposase WM43_05225 ENOG4108RS6 transposase WM43_05230 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) WM43_05240 ENOG4105VNH ABC transporter solute-binding protein WM43_05250 ENOG4108VGW abc transporter atp-binding protein WM43_05255 ENOG4108T9J Cdp-alcohol phosphatidyltransferase WM43_05260 ENOG4105CVE Lytic murein transglycosylase WM43_05265 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 WM43_05270 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) WM43_05275 ENOG4105EV9 Alpha Beta Hydrolase WM43_05285 ENOG4105NNH LexA regulated protein WM43_05290 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) WM43_05300 ENOG41090R7 Ferric uptake WM43_05305 ENOG4105CX6 glutaminyL-tRNA synthetase WM43_05310 ENOG4105E2D ec 3.2.1.52 WM43_05315 ENOG4105CI1 PTS System WM43_05320 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) WM43_05325 ENOG4105CE4 GlcNAc 6-P deacetylase WM43_05330 ENOG4105E2R ROK family WM43_05335 ENOG4105DIJ Phosphoethanolamine transferase WM43_05340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_05345 ENOG4108HRK Histidine kinase WM43_05350 ENOG4108NEV two component transcriptional regulator, LytTR family WM43_05360 ENOG4105KK7 inner membrane protein YiaW WM43_05365 ENOG4105EFX secretion protein, HlyD family WM43_05370 ENOG4105CFI type iii restriction protein res subunit WM43_05375 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase WM43_05380 ENOG41090BQ Glutaredoxin WM43_05395 ENOG4105NAU thioesterase Superfamily protein WM43_05400 ENOG4108535 NAD dependent epimerase/dehydratase family WM43_05410 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) WM43_05425 ENOG4105QVC MOSC domain-containing protein WM43_05425 ENOG4105QVC MOSC domain-containing protein WM43_05430 ENOG4107SDU Methyl-accepting chemotaxis WM43_05435 ENOG4105D0M Protease HtpX homolog WM43_05440 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) WM43_05445 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) WM43_05450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WM43_05455 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) WM43_05460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WM43_05475 ENOG4105C5S asparaginyl-tRNA synthetase WM43_05485 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WM43_05495 ENOG4105CH2 amidohydrolase WM43_05500 ENOG4105CEE C4-dicarboxylate transporter WM43_05510 ENOG4105KUZ arsenate reductase WM43_05515 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) WM43_05525 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) WM43_05540 ENOG410829K Lysine exporter protein (Lyse ygga) WM43_05550 ENOG4105RX8 Protein of unknown function (DUF1523) WM43_05565 ENOG4105DU0 nucleoside hydrolase WM43_05570 ENOG4105D3G Pseudouridine synthase WM43_05575 ENOG4107SXA Phosphorylase WM43_05580 ENOG4105C0A alcohol dehydrogenase WM43_05620 ENOG4107U53 septum site-determining protein minD WM43_05660 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WM43_05665 ENOG4105K4T epimerase WM43_05675 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) WM43_05685 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WM43_05690 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WM43_05695 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WM43_05700 ENOG4105EFX secretion protein, HlyD family WM43_05735 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase WM43_05750 ENOG4105WBN Transcriptional regulator (LacI family WM43_05755 ENOG4108HKT sucrose-6-phosphate hydrolase WM43_05765 ENOG4105D7K pfkb domain protein WM43_05775 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WM43_05780 ENOG4105CFG Acts as a chaperone (By similarity) WM43_05785 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ WM43_05790 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) WM43_05795 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) WM43_05800 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase WM43_05805 ENOG4105DJY efflux transporter, rnd family, mfp subunit WM43_05810 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) WM43_05815 ENOG4105ENJ RND efflux system, outer membrane lipoprotein WM43_05820 ENOG4108YX2 DNA-binding protein WM43_05830 ENOG4108ZQS transposase WM43_05835 ENOG4108MVM Transposase WM43_05845 ENOG4105E3R (LipO)protein WM43_05870 ENOG4108QY5 Ferric enterobactin transport protein WM43_05875 ENOG4105F2I Transposase WM43_05900 ENOG4105C1B dTDP-glucose 4-6-dehydratase WM43_05910 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase WM43_05920 ENOG4105D3Q Sugar transferase WM43_05930 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase WM43_05940 ENOG4105C5E polysaccharide biosynthesis protein WM43_05945 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase WM43_05955 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase WM43_05960 ENOG4105C1B dTDP-glucose 4-6-dehydratase WM43_05965 ENOG4105BZS acriflavin resistance protein WM43_05970 ENOG4105C1P efflux transporter, rnd family, mfp subunit WM43_05975 ENOG4108IG5 Transcriptional regulator WM43_05990 ENOG4105VYW UPF0251 protein WM43_06010 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) WM43_06015 ENOG4105F2I Transposase WM43_06020 ENOG4105D98 threonine synthase WM43_06025 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) WM43_06035 ENOG4106FVC RNA methyltransferase WM43_06040 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) WM43_06045 ENOG4105C29 acyl-CoA thioesterase WM43_06050 ENOG4105FE9 pseudouridine synthase WM43_06055 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) WM43_06065 ENOG4107RTD sua5 ycio yrdc ywlc family protein WM43_06070 ENOG4105DB7 PHP domain protein WM43_06075 ENOG4105CRQ synthase (Component I) WM43_06080 ENOG4108EFP Anthranilate synthase component II WM43_06085 ENOG4108I0Q anthranilate phosphoribosyltransferase WM43_06090 ENOG4105DK0 Indole-3-glycerol phosphate synthase WM43_06095 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) WM43_06100 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) WM43_06115 ENOG4105S2T inner membrane protein YbcI WM43_06135 ENOG4105D9N nucleoside WM43_06145 ENOG4105D6J arsenicaL-resistance protein WM43_06175 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) WM43_06185 ENOG41065U4 response regulator WM43_06200 ENOG4108JJ9 ABC, transporter WM43_06205 ENOG4108JJ8 (ABC) transporter WM43_06225 ENOG4108R96 Methyltransferase, YaeB family WM43_06230 ENOG4105CPW cytochrome b561 WM43_06240 ENOG4105XJC Two component transcriptional regulator (Winged helix family WM43_06265 ENOG410600T transposase WM43_06270 ENOG4106F1P AAA ATPase, central domain protein WM43_06290 ENOG4105CJP fad dependent oxidoreductase WM43_06295 ENOG4107VRI Transcriptional regulator WM43_06300 ENOG4105C26 Dehydrogenase WM43_06305 ENOG4108JPW Aminotransferase WM43_06310 ENOG4105CUB amino acid WM43_06320 ENOG4105CUB amino acid WM43_06335 ENOG4108V1T peptidylprolyl cis-trans isomerase WM43_06340 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) WM43_06345 ENOG4105DH7 May be involved in recombination (By similarity) WM43_06355 ENOG4107RH8 nuclease SbcCD subunit D WM43_06360 ENOG4105EYH Exonuclease WM43_06365 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b WM43_06375 ENOG4105CA9 Pyruvate kinase WM43_06380 ENOG4105EGS Mechanosensitive ion channel WM43_06390 ENOG4105C9K Endothelin-converting enzyme 1 WM43_06395 ENOG4105BZU Histidine kinase WM43_06400 ENOG4105C5Y PTS System WM43_06410 ENOG4105KZ7 phosphocarrier protein hpr WM43_06415 ENOG4105C6T cysteine synthase WM43_06435 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_06455 ENOG4105GVR general secretion pathway protein D WM43_06460 ENOG4107QHF type ii secretion system protein e WM43_06465 ENOG4105D7Q type ii secretion system WM43_06470 ENOG4108VAU general secretion pathway protein G WM43_06535 ENOG4108K4B hydrolase WM43_06540 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase WM43_06555 ENOG4108MN8 Membrane WM43_06560 ENOG4105EM2 membrane WM43_06565 ENOG4108Z0T Part of a sulfur-relay system (By similarity) WM43_06570 ENOG4105EP9 oxidoreductase WM43_06595 ENOG4105CCT upf0313 protein WM43_06605 ENOG4105J12 Multidrug resistance protein mdtN WM43_06610 ENOG4105BZU Histidine kinase WM43_06615 ENOG4105D78 K07001 NTE family protein WM43_06620 ENOG4107R7I amino acid WM43_06635 ENOG4105UYK outer membrane protein a WM43_06650 ENOG4105UYK outer membrane protein a WM43_06655 ENOG4107R1I NAD-dependent malic enzyme WM43_06660 ENOG4105ECQ AraC Family Transcriptional Regulator WM43_06665 ENOG4105UQX Mate efflux family protein WM43_06670 ENOG4105RKX Protein of unknown function (DUF2498) WM43_06675 ENOG4105BZU Histidine kinase WM43_06680 ENOG4105C2W permease WM43_06685 ENOG4108KMH lipoate-protein ligase a WM43_06690 ENOG4105BZG amino acid carrier protein WM43_06715 ENOG4105PTV Nudix Hydrolase WM43_06730 ENOG4108V1T peptidylprolyl cis-trans isomerase WM43_06735 ENOG4106N3A copper homeostasis protein cutc WM43_06750 ENOG4105ERG peptidase m48, ste24p WM43_06760 ENOG4105BZU Histidine kinase WM43_06765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family WM43_06770 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase WM43_06775 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WM43_06780 ENOG4105C26 Dehydrogenase WM43_06790 ENOG4108IPJ Membrane WM43_06795 ENOG4106YYS transcriptional regulatory protein WM43_06800 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism WM43_06805 ENOG4107R1I NAD-dependent malic enzyme WM43_06815 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) WM43_06820 ENOG4105J12 Multidrug resistance protein mdtN WM43_06845 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) WM43_06850 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase WM43_06860 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) WM43_06865 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) WM43_06870 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) WM43_06875 ENOG4105EXN Sulfate transport protein CysZ WM43_06880 ENOG4105EN6 Membrane WM43_06890 ENOG4105EAQ (twin-arginine translocation) pathway signal WM43_06895 ENOG4105DIT ErfK YbiS YcfS YnhG family protein WM43_06925 ENOG4107T9C Alpha amylase catalytic region WM43_06960 ENOG4105BZU Histidine kinase WM43_06965 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) WM43_06970 ENOG4105C9K Endothelin-converting enzyme 1 WM43_06985 ENOG4105CXN decarboxylase WM43_06990 ENOG4105D5Q Arginine ornithine antiporter WM43_06995 ENOG4108M3R transcriptional activator CadC WM43_07000 ENOG4105DVH amino acid WM43_07010 ENOG410600T transposase WM43_07030 ENOG4105C44 Serine transporter WM43_07035 ENOG4105EQ2 LysR family Transcriptional regulator WM43_07045 ENOG4105C7K acetolactate synthase WM43_07060 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WM43_07065 ENOG4105DR5 peptidase WM43_07070 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) WM43_07105 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) WM43_07110 ENOG4106KR7 LysR family Transcriptional regulator WM43_07130 ENOG4105CV1 Transketolase (EC 2.2.1.1) WM43_07135 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP WM43_07140 ENOG4105GPY SprT protein WM43_07150 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) WM43_07155 ENOG4105D7Z glutathione synthase WM43_07165 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) WM43_07170 ENOG4105DUX Transporter WM43_07175 ENOG4105G2Y Transcriptional regulator WM43_07185 ENOG4105C7R Atpase associated with various cellular activities aaa_3 WM43_07195 ENOG4105F8C transglutaminase domain-containing protein WM43_07200 ENOG4105BZG amino acid carrier protein WM43_07205 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) WM43_07215 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) WM43_07220 ENOG4105C0B DNA polymerase III (alpha subunit) WM43_07225 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WM43_07230 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WM43_07235 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WM43_07240 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) WM43_07245 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WM43_07250 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) WM43_07255 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WM43_07260 ENOG4105DZP Membrane-associated zinc metalloprotease WM43_07265 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) WM43_07270 ENOG4105KNE Phosphatidate cytidylyltransferase WM43_07275 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) WM43_07280 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) WM43_07285 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) WM43_07290 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) WM43_07295 ENOG4105CE9 30S ribosomal protein S2 WM43_07300 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) WM43_07305 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) WM43_07310 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) WM43_07315 ENOG4108T8E UPF0325 protein WM43_07320 ENOG4105CI1 PTS System WM43_07325 ENOG4107W52 maltose operon periplasmic protein WM43_07335 ENOG4105QDK Flavodoxin WM43_07340 ENOG4105DR9 pseudouridine synthase WM43_07345 ENOG4105WP7 tRNA pseudouridine synthase C WM43_07370 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein WM43_07410 ENOG4108ZQS transposase WM43_07415 ENOG4108MVM Transposase WM43_07460 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WM43_07480 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) WM43_07485 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) WM43_07495 ENOG4105BZU Histidine kinase WM43_07500 ENOG4105EWT decarboxylase family WM43_07505 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease WM43_07510 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) WM43_07520 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) WM43_07525 ENOG4105M08 Membrane WM43_07535 ENOG4105ETT transcriptional Regulator, LysR family WM43_07540 ENOG4105C8Q Methyl-accepting chemotaxis WM43_07545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WM43_07555 ENOG4107S0N DJ-1 family WM43_07560 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) WM43_07565 ENOG4108VPT UPF0234 protein WM43_07575 ENOG4105EYM Major Facilitator superfamily WM43_07580 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) WM43_07590 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) WM43_07595 ENOG4105M85 Bola protein WM43_07600 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WM43_07605 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WM43_07610 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WM43_07615 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WM43_07620 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) WM43_07625 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) WM43_07630 ENOG4105CJ2 (LipO)protein WM43_07660 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase WM43_07675 ENOG4107FW0 short-chain dehydrogenase reductase WM43_07685 ENOG4105CVP deoxyribo-dipyrimidine photolyase WM43_07690 ENOG4108XDN Transcriptional regulator WM43_07695 ENOG4107SEY Conserved Protein WM43_07710 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WM43_07725 ENOG4105CQC Prephenate dehydratase WM43_07755 ENOG4108NF7 phage-type endonuclease WM43_07800 ENOG4105W5Q DNA repair protein (RadC WM43_07815 ENOG4108QDQ Ubiquinol-cytochrome C chaperone WM43_07835 ENOG410600T transposase WM43_07855 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WM43_07860 ENOG4105C0D helicase WM43_07875 ENOG410600T transposase WM43_07895 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) WM43_07900 ENOG4107R3N Filamentation induced by cAMP protein fic WM43_07930 ENOG4108W2P Methyl-accepting chemotaxis WM43_07940 ENOG4105E1F short-chain dehydrogenase reductase WM43_07965 ENOG4105CTD carboxy-peptidase WM43_08005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) WM43_08010 ENOG4105CFP Peptidase U32 WM43_08015 ENOG4105N14 lysine exporter protein LysE YggA WM43_08025 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) WM43_08030 ENOG4105C8Q Methyl-accepting chemotaxis WM43_08035 ENOG4108VYJ response regulator receiver protein WM43_08045 ENOG4105CBS Chea signal transduction histidine kinase WM43_08055 ENOG4108V3W Chemotaxis protein, CheW WM43_08060 ENOG4105C8Q Methyl-accepting chemotaxis WM43_08065 ENOG4105BZU Histidine kinase WM43_08070 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) WM43_08075 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) WM43_08080 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) WM43_08085 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) WM43_08090 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) WM43_08095 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) WM43_08100 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) WM43_08105 ENOG4105CHV Transcription elongation factor NusA WM43_08110 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) WM43_08130 ENOG4105CP7 Triose-phosphate isomerase WM43_08135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) WM43_08140 ENOG4105EEI dihydropteroate synthase WM43_08145 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) WM43_08150 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) WM43_08155 ENOG4105HBR Rna-binding protein WM43_08165 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) WM43_08170 ENOG4107XSU flagellar motor protein motb WM43_08175 ENOG4105E14 MotA TolQ exbB proton channel WM43_08180 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) WM43_08185 ENOG4105CTB Polyprenyl synthetase WM43_08190 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) WM43_08195 ENOG4105CGH 5'-nucleotidase WM43_08215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_08220 ENOG4108V1T peptidylprolyl cis-trans isomerase WM43_08230 ENOG41069P5 Protein slyX homolog WM43_08240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WM43_08250 ENOG4108JQ6 ABC transporter WM43_08255 ENOG4108ZAI phosphatidylglycerophosphatase a WM43_08260 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) WM43_08265 ENOG4107YIM Involved in the transcription termination process (By similarity) WM43_08270 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) WM43_08285 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) WM43_08290 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) WM43_08300 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) WM43_08310 ENOG4105BZU Histidine kinase WM43_08315 ENOG4108SV3 Tmao reductase system periplasmic protein tort WM43_08325 ENOG4106WF9 DNA-binding transcriptional regulator TorR WM43_08330 ENOG4105CUW cytochrome C-TYPE protein WM43_08335 ENOG4108EM1 reductase WM43_08340 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) WM43_08350 ENOG4105BZU Histidine kinase WM43_08360 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WM43_08365 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) WM43_08370 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein WM43_08375 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase WM43_08380 ENOG4105RG0 Membrane WM43_08385 ENOG4108IA2 Sodium pantothenate symporter WM43_08390 ENOG4105CI1 PTS System WM43_08395 ENOG4105HEI LysR family (Transcriptional regulator WM43_08400 ENOG4105CIS alcohol dehydrogenase WM43_08405 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) WM43_08415 ENOG41069NU Nitroreductase WM43_08420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WM43_08425 ENOG4105D07 Signal peptide peptidase, SppA WM43_08430 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WM43_08440 ENOG4105CMM transposase WM43_08455 ENOG4109015 Biopolymer transport protein exbD tolR WM43_08475 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WM43_08480 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component WM43_08485 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component WM43_08500 ENOG4108JQ7 (ABC) transporter WM43_08510 ENOG4105C6Y Udp-glucose 6-dehydrogenase WM43_08520 ENOG4105G4C Periplasmic ligand-binding sensor protein WM43_08530 ENOG4105E4C Lytic transglycosylase catalytic WM43_08545 ENOG4105C5H ABC transporter WM43_08555 ENOG4105C7N Xanthine uracil vitamin C permease WM43_08560 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) WM43_08565 ENOG4105C8Q Methyl-accepting chemotaxis WM43_08575 ENOG4105VEQ Cold shock protein WM43_08615 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) WM43_08625 ENOG4105DJ4 phosphatidylserine decarboxylase WM43_08630 ENOG4105VYA Uncharacterized conserved protein (DUF2132) WM43_08645 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) WM43_08660 ENOG4105V1F Fermentation respiration switch protein WM43_08665 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) WM43_08670 ENOG4105CIN aminoacyl-histidine dipeptidase WM43_08675 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) WM43_08680 ENOG4108S0S Nucleotidyl transferase WM43_08685 ENOG4105EHM Aminoglycoside phosphotransferase WM43_08690 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) WM43_08695 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) WM43_08700 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) WM43_08705 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) WM43_08710 ENOG4105NWN ApaG protein WM43_08715 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) WM43_08730 ENOG4105DEN Luciferase family WM43_08740 ENOG4105DWD nucleoside recognition domain protein WM43_08745 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control WM43_08750 ENOG4105K46 50S ribosomal protein l27 WM43_08755 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) WM43_08760 ENOG4105EAH synthase WM43_08770 ENOG4105EPW hflc protein WM43_08775 ENOG4107QJR hflk protein WM43_08780 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) WM43_08785 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WM43_08790 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) WM43_08795 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WM43_08800 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) WM43_08805 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase WM43_08810 ENOG4105K8N protein family UPF0079, ATPase WM43_08815 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) WM43_08820 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) WM43_08835 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) WM43_08840 ENOG4108UMI ABC transporter, permease WM43_08845 ENOG4105D01 (LipO)protein WM43_08850 ENOG4105MDZ Transcriptional activator rfaH WM43_08855 ENOG4108NVR Methyl-accepting chemotaxis WM43_08860 ENOG4105BZU Histidine kinase WM43_08865 ENOG4105BZU Histidine kinase WM43_08875 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein WM43_08880 ENOG4105BZU Histidine kinase WM43_08900 ENOG4108Q67 UPF0319 protein WM43_08905 ENOG4105EXG Transcriptional regulator WM43_08915 ENOG4107QWK SAICAR synthetase WM43_08920 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WM43_08925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WM43_08930 ENOG4105RH4 Glycine cleavage system transcriptional repressor WM43_08935 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WM43_08940 ENOG4105XWI UPF0304 protein WM43_08945 ENOG4105PQ6 UPF0208 membrane protein WM43_08950 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WM43_08955 ENOG4105C6K Malic enzyme WM43_08960 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein WM43_08965 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase WM43_08970 ENOG4105DUX Transporter WM43_08975 ENOG4105I93 response regulator WM43_09005 ENOG4107V40 secretion protein, HlyD family WM43_09015 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WM43_09020 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) WM43_09045 ENOG4107R11 Transcriptional regulator WM43_09050 ENOG4108NIW Leucine export protein LeuE WM43_09055 ENOG4108ZP8 Acetolactate synthase small subunit WM43_09060 ENOG4105C7K acetolactate synthase WM43_09080 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) WM43_09090 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WM43_09095 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) WM43_09110 ENOG4105DP9 ABC transporter WM43_09115 ENOG4106SMU thiamine transporter membrane protein WM43_09120 ENOG4107T0D ABC, transporter WM43_09125 ENOG4108IAB Phoh family WM43_09135 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) WM43_09165 ENOG4105BZU Histidine kinase WM43_09175 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) WM43_09180 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) WM43_09195 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 WM43_09200 ENOG4108IJ0 Aspartate ammonia-lyase WM43_09205 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter WM43_09210 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WM43_09215 ENOG4105VCC 30S ribosomal protein S21 WM43_09220 ENOG4105KTH gatB Yqey WM43_09225 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) WM43_09230 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WM43_09270 ENOG4105DFP Integrase WM43_09285 ENOG4105C12 Phosphoribosylglycinamide synthetase WM43_09290 ENOG4105DC1 bifunctional purine biosynthesis protein purh WM43_09300 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system WM43_09305 ENOG4105CSA Coproporphyrinogen iii oxidase WM43_09310 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) WM43_09320 ENOG4105D9R oxidoreductase WM43_09330 ENOG4105D9U N-acetyltransferase WM43_09335 ENOG4108Z9I -acetyltransferase WM43_09350 ENOG4105EV4 Multidrug resistance protein mdtH WM43_09355 ENOG4108MJ3 acetyltransferase WM43_09360 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) WM43_09365 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr WM43_09370 ENOG4105BZU Histidine kinase WM43_09375 ENOG4105EV2 VWA domain protein interacting with AAA ATPase WM43_09390 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) WM43_09400 ENOG4108IQE Amp-dependent synthetase and ligase WM43_09405 ENOG4105D9M gamma-glutamylcysteine synthetase WM43_09415 ENOG4105W39 Membrane WM43_09420 ENOG4105DQ4 alcohol dehydrogenase WM43_09440 ENOG4105DP0 ferredoxin-NADP reductase WM43_09445 ENOG4105K9Q Binds to the 23S rRNA (By similarity) WM43_09450 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) WM43_09455 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) WM43_09460 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) WM43_09465 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WM43_09475 ENOG4105K70 DNA-binding protein WM43_09480 ENOG4105PBF Anti-RNA polymerase sigma 70 factor WM43_09490 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) WM43_09505 ENOG4105EAC phosphoserine phosphatase WM43_09515 ENOG4105D3A purine nucleoside phosphorylase DeoD-type WM43_09520 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) WM43_09525 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) WM43_09530 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) WM43_09540 ENOG4105D9N nucleoside WM43_09545 ENOG4105EYA deoxyribonuclease WM43_09555 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) WM43_09565 ENOG4108YZA Nitrogen regulatory protein pii WM43_09570 ENOG4105C4K Nad synthetase WM43_09610 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) WM43_09615 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase WM43_09620 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) WM43_09625 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) WM43_09630 ENOG4105DTN riboflavin biosynthesis protein ribF WM43_09635 ENOG4105CJR Integral membrane protein (MviN WM43_09640 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) WM43_09645 ENOG41080HT Transcriptional regulator, arsr family WM43_09650 ENOG41063Z6 transcriptional regulator, lysR family WM43_09660 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WM43_09665 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) WM43_09670 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) WM43_09675 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase WM43_09680 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WM43_09685 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) WM43_09695 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) WM43_09700 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) WM43_09705 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) WM43_09710 ENOG4105K5M 30s ribosomal protein S16 WM43_09715 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY WM43_09720 ENOG4106KVJ cytochrome C assembly protein WM43_09725 ENOG4108JU6 CBS domain protein WM43_09735 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WM43_09740 ENOG4108UV7 flagellar protein motX WM43_09745 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) WM43_09750 ENOG4105DMR ABC, transporter WM43_09755 ENOG4105GBT ABC transporter WM43_09760 ENOG4106PMH Extracellular solute-binding protein family 3 WM43_09765 ENOG4105E5Z arginine transporter ATP-binding subunit WM43_09770 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) WM43_09775 ENOG4105EZR dyp-type peroxidase family protein WM43_09780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WM43_09795 ENOG4108YZA Nitrogen regulatory protein pii WM43_09800 ENOG4108YZN class I peptide chain release factor WM43_09815 ENOG4105D1Q UPF0246 protein WM43_09820 ENOG4105CZX twitching motility protein WM43_09825 ENOG4105CZX twitching motility protein WM43_09830 ENOG4105DFA alanine racemase domain protein WM43_09835 ENOG4105II7 pyrroline-5-carboxylate reductase WM43_09840 ENOG4108VIA integral membrane protein WM43_09845 ENOG4105VZ9 UPF0235 protein WM43_09855 ENOG4105D9N nucleoside WM43_09860 ENOG4105HEI LysR family (Transcriptional regulator WM43_09875 ENOG4105BZW Glycerate kinase WM43_09880 ENOG4107QQ0 gntp family WM43_09885 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR WM43_09890 ENOG4105XTV UPF0231 protein WM43_09910 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) WM43_09920 ENOG4105C1J atp-dependent rna helicase WM43_09930 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) WM43_09960 ENOG4105CGF Aromatic amino acid aminotransferase WM43_09975 ENOG41076CZ activating enzyme WM43_09980 ENOG4105G0K glycine radical enzyme YjjI family WM43_10005 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein WM43_10020 ENOG4105C8Q Methyl-accepting chemotaxis WM43_10025 ENOG4108M1A Chitin-binding protein WM43_10030 ENOG4107R11 Transcriptional regulator WM43_10035 ENOG4108IJ6 ABC transporter WM43_10040 ENOG4105ECW sulfate abc transporter WM43_10045 ENOG4108I5D sulfate abc transporter WM43_10055 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein WM43_10060 ENOG4107PU6 Membrane WM43_10065 ENOG4108UW5 maltose o-acetyltransferase WM43_10080 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 WM43_10085 ENOG4107RK2 ADP-ribose diphosphatase NudE WM43_10090 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase WM43_10095 ENOG4105C44 Serine transporter WM43_10100 ENOG4108Z7R Chaperone CsaA WM43_10110 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) WM43_10115 ENOG4105C28 cystathionine WM43_10120 ENOG4105CFH Aspartokinase WM43_10125 ENOG4105CJ3 phosphate transporter WM43_10130 ENOG4107IX6 phosphate transport regulator WM43_10140 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) WM43_10145 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) WM43_10150 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) WM43_10155 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) WM43_10195 ENOG4105DFD Na H antiporter WM43_10200 ENOG4108YX9 iron--sulfur cluster insertion protein erpA WM43_10210 ENOG4105CMQ Chloride channel WM43_10215 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase WM43_10230 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) WM43_10260 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) WM43_10265 ENOG4105D3G Pseudouridine synthase WM43_10275 ENOG4108UW5 maltose o-acetyltransferase WM43_10280 ENOG4105CG3 alpha amylase, catalytic region WM43_10285 ENOG4105C5Y PTS System WM43_10290 ENOG4105D4X repressor WM43_10305 ENOG4105HDK L-asparaginase WM43_10315 ENOG4106W5V Membrane WM43_10320 ENOG41061WM D-Alanyl-D-Alanine WM43_10355 ENOG4105CFH Aspartokinase WM43_10360 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) WM43_10370 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) WM43_10375 ENOG4107TH8 cina domain protein WM43_10380 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) WM43_10385 ENOG4108NRW Phospholipase, patatin family WM43_10395 ENOG41067MG lrgb family WM43_10405 ENOG4105CMU LysR family (Transcriptional regulator WM43_10415 ENOG4108Z66 YbaK ebsC protein WM43_10435 ENOG4105D41 biosynthesis protein thiH WM43_10440 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) WM43_10450 ENOG4105D06 uba thif-type nad fad binding protein WM43_10455 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) WM43_10460 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) WM43_10480 ENOG4105ETX regulatoR WM43_10490 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) WM43_10495 ENOG4105C3R Methionine synthase WM43_10500 ENOG4105EEQ Na H antiporter WM43_10530 ENOG4105CSH Transporter WM43_10545 ENOG4105D1U peptidase U62 modulator of DNA gyrase WM43_10565 ENOG4105QD6 exported protein WM43_10570 ENOG4105C03 ribonuclease WM43_10575 ENOG4108Z03 MAF-like protein WM43_10580 ENOG4105VQ7 Rod shape-determining protein MreD WM43_10585 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) WM43_10590 ENOG4105DFF Rod shape-determining protein mreb WM43_10615 ENOG4106855 Competence protein WM43_10635 ENOG4105D7Q type ii secretion system WM43_10640 ENOG4107QHF type ii secretion system protein e WM43_10655 ENOG4105GVR general secretion pathway protein D WM43_10685 ENOG41062P1 Diguanylate cyclase phosphodiesterase WM43_10705 ENOG4105EWV Sodium calcium exchanger membrane region WM43_10710 ENOG4105C84 Histidine ammonia-lyase WM43_10715 ENOG4105CGP Urocanate hydratase WM43_10720 ENOG41088SP formiminoglutamate hydrolase WM43_10725 ENOG4105CI2 imidazolone-5-propionate hydrolase WM43_10730 ENOG4105CZE histidine utilization repressor WM43_10735 ENOG41077A9 carbonic anhydrase WM43_10745 ENOG4105CRP Part of the ABC transporter FtsEX involved in WM43_10750 ENOG4105CAK Cell division ATP-binding protein ftsE WM43_10755 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) WM43_10760 ENOG4106H78 methyltransferase WM43_10785 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein WM43_10790 ENOG4108W5M transcriptional regulator WM43_10795 ENOG4105EMU Dehydrogenase WM43_10810 ENOG4105CUG Oligopeptidase b WM43_10825 ENOG4107RZC phospholipase d WM43_10830 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) WM43_10850 ENOG41076UM multiple antibiotic resistance (MarC)-related protein WM43_10855 ENOG4105VVZ metal-binding protein WM43_10870 ENOG4105JQN Transcriptional regulator WM43_10885 ENOG4107FS9 Membrane WM43_10895 ENOG4105EJ2 Transcriptional regulator WM43_10900 ENOG4108Y73 Membrane WM43_10930 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase WM43_10935 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WM43_10940 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) WM43_10945 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) WM43_10950 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) WM43_10955 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) WM43_10960 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) WM43_10965 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) WM43_10970 ENOG4105KME endoribonuclease L-psp WM43_10975 ENOG4105WWK YheO domain protein WM43_10980 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WM43_10985 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WM43_10990 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) WM43_10995 ENOG4108VZM 50s ribosomal protein L10 WM43_11000 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) WM43_11005 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) WM43_11010 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) WM43_11015 ENOG4105PM1 preprotein translocase subunit SecE WM43_11025 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) WM43_11045 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase WM43_11050 ENOG4105D4A Cell wall formation (By similarity) WM43_11055 ENOG4107ZYR domain protein WM43_11080 ENOG4108IYH Dna topoisomerase WM43_11090 ENOG4105BZU Histidine kinase WM43_11095 ENOG4105CUW cytochrome C-TYPE protein WM43_11100 ENOG4107QY8 reductase WM43_11110 ENOG4105IFJ Histidine kinase WM43_11115 ENOG4105XJC Two component transcriptional regulator (Winged helix family WM43_11140 ENOG4108UQ5 membrane protein YcdZ WM43_11145 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_11155 ENOG4107WP9 Histidine kinase WM43_11165 ENOG410642E Short chain dehydrogenase WM43_11170 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WM43_11185 ENOG4108VVK transcriptional Regulator, AsnC WM43_11190 ENOG4105CU9 asparagine synthetase A WM43_11195 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit WM43_11200 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase WM43_11205 ENOG4105C34 Pseudouridine synthase WM43_11210 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane WM43_11215 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WM43_11225 ENOG4105CEM UPF0597 protein WM43_11230 ENOG4105WWK YheO domain protein WM43_11240 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WM43_11245 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) WM43_11250 ENOG4108I6A alcohol dehydrogenase WM43_11255 ENOG4105CF7 AraC family transcriptional regulator WM43_11260 ENOG4105QNF Outer membrane lipoprotein WM43_11265 ENOG4105C8Q Methyl-accepting chemotaxis WM43_11275 ENOG4105DUM transcriptional regulator, lysR family WM43_11290 ENOG4105CXT aspartate transcarbamylase WM43_11295 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) WM43_11300 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) WM43_11305 ENOG4105CSX c4-dicarboxylate anaerobic carrier WM43_11310 ENOG4105DBV ornithine carbamoyltransferase WM43_11315 ENOG4105C5B carbamate kinase WM43_11335 ENOG4105D4P Coproporphyrinogen iii oxidase WM43_11340 ENOG4105XCT Protein of unknown function (DUF2489) WM43_11345 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) WM43_11355 ENOG4106RE7 Cytochrome WM43_11360 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) WM43_11375 ENOG4105E2X shikimate dehydrogenase WM43_11380 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) WM43_11385 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) WM43_11395 ENOG4108WI1 Dna topoisomerase WM43_11400 ENOG4108RPN Protein smg homolog WM43_11405 ENOG4105C79 DNA protecting protein DprA WM43_11410 ENOG4108WZM domain protein WM43_11415 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) WM43_11420 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) WM43_11425 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B WM43_11430 ENOG4105C1A potassium transporter peripheral membrane WM43_11435 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) WM43_11445 ENOG4105C5F glutamine synthetase WM43_11455 ENOG4105CUX Signal transduction histidine kinase WM43_11460 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_11465 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) WM43_11470 ENOG4105CGY Dna recombination protein WM43_11490 ENOG4108TFM Kinase, PfkB family WM43_11495 ENOG4107R11 Transcriptional regulator WM43_11500 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) WM43_11505 ENOG4105C26 Dehydrogenase WM43_11515 ENOG4108JCI Transcriptional regulator WM43_11520 ENOG4105C26 Dehydrogenase WM43_11525 ENOG4105FR1 rard protein WM43_11535 ENOG4105CUC YeeE YedE family protein WM43_11540 ENOG4105UYK outer membrane protein a WM43_11545 ENOG4105C7B Threonine dehydratase WM43_11550 ENOG4105C01 Dihydroxy-acid dehydratase WM43_11555 ENOG4105CM2 brancheD-chain amino acid aminotransferase WM43_11560 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit WM43_11570 ENOG4105C0P Mg chelatase subunit ChlI WM43_11575 ENOG4106HNH Acyl-transferase WM43_11580 ENOG4106HNH Acyl-transferase WM43_11585 ENOG4105EWC Purine nucleoside phosphorylase WM43_11595 ENOG4108RWI nicotinamidase WM43_11600 ENOG4107RH7 Nicotinate phosphoribosyltransferase WM43_11605 ENOG4108Z33 Thiol disulfide Interchange Protein WM43_11610 ENOG4105E27 serine threonine protein kinase WM43_11620 ENOG4105PC1 Conserved Protein WM43_11630 ENOG4108Z6Z Transcriptional regulator WM43_11640 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) WM43_11645 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) WM43_11650 ENOG4105DSJ YicC domain protein WM43_11655 ENOG4105CC0 LysR family Transcriptional regulator WM43_11665 ENOG4105C4W S-formylglutathione hydrolase WM43_11670 ENOG4105CR8 Transcriptional regulator WM43_11715 ENOG4105DHU Bile acid WM43_11720 ENOG4105E5D amino acid WM43_11725 ENOG4108Y51 tRNA-binding protein WM43_11730 ENOG4105E5D amino acid WM43_11735 ENOG4105FK9 beta-D-galactosidase beta subunit WM43_11740 ENOG4105CNT hydrolase family 2 WM43_11745 ENOG4105CQ4 Transcriptional regulator WM43_11780 ENOG4108Z0R Transferase WM43_11785 ENOG4105C2M dna polymerase I WM43_11790 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain WM43_11795 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) WM43_11805 ENOG4105D7W serine acetyltransferase WM43_11815 ENOG4105E3W Two component transcriptional regulator (Winged helix family WM43_11820 ENOG4105E0F Histidine kinase WM43_11825 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) WM43_11830 ENOG4107R73 Mate efflux family protein WM43_11845 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) WM43_11850 ENOG4105E55 glycerol-3-phosphate acyltransferase WM43_11855 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) WM43_11860 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) WM43_11880 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family WM43_11885 ENOG4105DIQ Transcriptional regulator WM43_11890 ENOG4106ETB IIa component WM43_11905 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase WM43_11910 ENOG4105XA0 heptosyltransferase ii WM43_11915 ENOG4106WTF Glycosyl transferase, family 2 WM43_11920 ENOG4105M5K heptosyltransferase WM43_11925 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) WM43_11930 ENOG4108MJ5 VirK protein WM43_11935 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) WM43_11945 ENOG4105W0E 50S ribosomal protein L33 WM43_11950 ENOG4105KDC 50s ribosomal protein l28 WM43_11955 ENOG4105W5Q DNA repair protein (RadC WM43_11960 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase WM43_11965 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) WM43_11970 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) WM43_11975 ENOG4105D64 Mechanosensitive ion channel WM43_11980 ENOG4107QP8 phosphohexose isomerase WM43_11985 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase WM43_11990 ENOG4105EMY transcriptional regulator WM43_12005 ENOG4105CD5 CoA-binding domain protein WM43_12035 ENOG4108RR8 protoporphyrinogen oxidase WM43_12040 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) WM43_12045 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein WM43_12050 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) WM43_12055 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) WM43_12060 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase WM43_12065 ENOG4105CHU acetyl-coa acetyltransferase WM43_12070 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WM43_12075 ENOG4105E0F Histidine kinase WM43_12090 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WM43_12095 ENOG4105M4H endoribonuclease L-psp WM43_12100 ENOG4108ZG0 Ompa motb domain protein WM43_12105 ENOG4108R3E Dna-3-methyladenine glycosylase i WM43_12110 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit WM43_12115 ENOG4105C38 Glycyl-tRNA synthetase beta subunit WM43_12125 ENOG4105CXC rtn protein WM43_12135 ENOG4105C8Q Methyl-accepting chemotaxis WM43_12140 ENOG4105FDP GntR family transcriptional regulator WM43_12145 ENOG4105CI1 PTS System WM43_12150 ENOG4105F8D glycoside hydrolase family 4 WM43_12155 ENOG4105ETE Transcriptional regulator (LacI family WM43_12160 ENOG4105CP9 extracellular ligand-binding receptor WM43_12165 ENOG4105C32 Amino acid ABC transporter (Permease) WM43_12170 ENOG4105CF8 branched-chain amino acid ABC transporter, permease WM43_12175 ENOG4105C0Z ABC transporter WM43_12180 ENOG4108IV0 ABC, transporter WM43_12185 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) WM43_12200 ENOG4105W0Z cytoplasmic protein WM43_12210 ENOG4107QK7 reductase WM43_12215 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) WM43_12225 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) WM43_12230 ENOG4105K63 Thioredoxin WM43_12235 ENOG4105C1J atp-dependent rna helicase WM43_12240 ENOG4105C9X ppx gppa phosphatase WM43_12250 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) WM43_12255 ENOG4105BZU Histidine kinase WM43_12260 ENOG4105DGW oligopeptidase A WM43_12265 ENOG4105E03 chitinase WM43_12270 ENOG4108M1A Chitin-binding protein WM43_12275 ENOG4105D52 delta-aminolevulinic acid dehydratase WM43_12280 ENOG4105F8V Hydrolase, tatD family WM43_12285 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) WM43_12290 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) WM43_12295 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) WM43_12300 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) WM43_12305 ENOG4105JC1 sterol-binding domain protein WM43_12310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) WM43_12315 ENOG4105WMR Protein CrcB homolog WM43_12320 ENOG4105DZC cytosine deaminase WM43_12325 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin WM43_12365 ENOG410822N TonB family WM43_12370 ENOG4109015 Biopolymer transport protein exbD tolR WM43_12390 ENOG4105VJY transcriptional regulator WM43_12395 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) WM43_12400 ENOG410804X Transcriptional regulator WM43_12405 ENOG4105E3W Two component transcriptional regulator (Winged helix family WM43_12410 ENOG4105EB3 Histidine kinase WM43_12425 ENOG4105CT7 inner membrane cred family protein WM43_12440 ENOG4107RA4 Glycosyl transferase (Group 1 WM43_12470 ENOG4105D75 Capsular exopolysaccharide family WM43_12485 ENOG4105D3Q Sugar transferase WM43_12490 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) WM43_12495 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) WM43_12500 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) WM43_12505 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) WM43_12510 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) WM43_12515 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WM43_12520 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WM43_12525 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) WM43_12530 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) WM43_12540 ENOG4105FA0 parb-like partition protein WM43_12545 ENOG4107QJE Chromosome Partitioning Protein WM43_12550 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) WM43_12555 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) WM43_12560 ENOG4105QTB Flavodoxin WM43_12570 ENOG4105IBP Cyclic peptide transporter WM43_12575 ENOG4105E0A ABC, transporter WM43_12580 ENOG4105J76 Periplasmic binding protein WM43_12585 ENOG4105S6R Iron-hydroxamate transporter permease subunit WM43_12590 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) WM43_12595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins WM43_12600 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) WM43_12605 ENOG4105VG0 50S ribosomal protein l34 WM43_12610 ENOG4105CDA abc transporter atp-binding protein WM43_12615 ENOG4105E5Q amino acid AbC transporter WM43_12620 ENOG4105EAB amino acid AbC transporter WM43_12625 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) WM43_12630 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) WM43_12635 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) WM43_12640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WM43_12650 ENOG4105D29 Helix-turn-helix type 11 domain protein WM43_12655 ENOG4105ECQ AraC Family Transcriptional Regulator WM43_12660 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein WM43_12665 ENOG4108ZNX Heat shock protein WM43_12670 ENOG4108ZNX Heat shock protein WM43_12675 ENOG4105JKW Valine--pyruvate aminotransferase WM43_12690 ENOG4105C2C drug resistance transporter, Bcr CflA WM43_12695 ENOG4105EEX Two component transcriptional regulator (Winged helix family WM43_12700 ENOG4105C08 Histidine kinase WM43_12710 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WM43_12715 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) WM43_12720 ENOG4105DC8 reductase WM43_12725 ENOG4105BZU Histidine kinase WM43_12730 ENOG4105BZS acriflavin resistance protein WM43_12735 ENOG410624X efflux transporter, rnd family, mfp subunit WM43_12740 ENOG4105Y7M Transcriptional regulator, TetR family WM43_12770 ENOG4105DQF Hydrolase WM43_12775 ENOG4108EUD Lysophospholipase WM43_12785 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase WM43_12790 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WM43_12795 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) WM43_12800 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) WM43_12810 ENOG4105DKP glycosyl transferase, family 9 WM43_12815 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) WM43_12825 ENOG4105EMK carboxylate amino acid amine transporter WM43_12850 ENOG4108M6U Universal stress protein A WM43_12855 ENOG4105RKW reductase (By WM43_12860 ENOG41090A1 ferritin WM43_12865 ENOG4105CBX hi0933 family WM43_12870 ENOG4108HRK Histidine kinase WM43_12875 ENOG4105DY9 regulatoR WM43_12880 ENOG4105FCD Major Facilitator WM43_12885 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit WM43_12890 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) WM43_12905 ENOG41063Z6 transcriptional regulator, lysR family WM43_12910 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) WM43_12915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) WM43_12950 ENOG4105CUZ uba thif-type nad fad binding protein WM43_12955 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) WM43_12960 ENOG4105C9B Cysteine desulfurase WM43_12965 ENOG4105C4R Atp-dependent dna helicase WM43_12970 ENOG4105BZU Histidine kinase WM43_12975 ENOG4105MPD Cytochrome WM43_12980 ENOG4105CPQ Dehydrogenase WM43_12985 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) WM43_12990 ENOG41062JF Transcriptional regulator WM43_12995 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) WM43_13000 ENOG4105E2K Glycosyl transferase (Group 1 WM43_13040 ENOG41061EV selenium-binding protein YdfZ WM43_13060 ENOG4105C4R Atp-dependent dna helicase WM43_13065 ENOG4105DIH basic membrane WM43_13070 ENOG4108JQ9 ABC transporter WM43_13075 ENOG4105UIB (ABC) transporter WM43_13085 ENOG4105CGH 5'-nucleotidase WM43_13095 ENOG4105CJW magnesium transporter WM43_13100 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WM43_13105 ENOG4107V9H nitrite transporter WM43_13110 ENOG4105WZK nitrite reductase NADPH small subunit WM43_13115 ENOG4107QZF nitrite reductase NADPH large subunit WM43_13120 ENOG4107QWP ABC-2 type transporter WM43_13125 ENOG4107QWP ABC-2 type transporter WM43_13130 ENOG4105CJ1 ABC, transporter WM43_13135 ENOG4105D0S secretion protein (HlyD WM43_13145 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) WM43_13150 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) WM43_13160 ENOG4105C75 arginyL-tRNA synthetase WM43_13170 ENOG4105K6V RNA polymerase WM43_13180 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) WM43_13185 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) WM43_13190 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) WM43_13195 ENOG4105F0Z galactose-1-phosphate uridylyltransferase WM43_13200 ENOG4105CMR udp-glucose 4-epimerase WM43_13205 ENOG41060NJ transcriptional regulator WM43_13210 ENOG4105CNT hydrolase family 2 WM43_13220 ENOG4105C2J ABC transporter WM43_13225 ENOG4108HWV )-transporter WM43_13230 ENOG4105C8Q Methyl-accepting chemotaxis WM43_13235 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) WM43_13250 ENOG4107R28 alpha amylase, catalytic region WM43_13265 ENOG4105R8A Heat shock protein WM43_13270 ENOG4105C5I Dehydrogenase WM43_13275 ENOG4108RH0 Crea protein WM43_13290 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters WM43_13295 ENOG4105CFQ glutamine synthetase WM43_13300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) WM43_13310 ENOG4108HM4 ABC transporter WM43_13315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WM43_13320 ENOG4105F38 ABC transporter, permease WM43_13325 ENOG4105D38 putrescine abc transporter WM43_13330 ENOG4108RPX mosc domain containing protein WM43_13345 ENOG4108VUY thioesterase Superfamily protein WM43_13350 ENOG4105C9U ATP-dependent DNA helicase RecQ WM43_13355 ENOG4105N7H Cytochrome WM43_13360 ENOG4105CNG UPF0061 protein WM43_13370 ENOG4105EX9 Membrane WM43_13375 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) WM43_13380 ENOG4108NVR Methyl-accepting chemotaxis WM43_13390 ENOG4105VFB Binds the 23S rRNA (By similarity) WM43_13395 ENOG4105C25 Primosomal protein n' WM43_13405 ENOG4105CGD Nad-dependent epimerase dehydratase WM43_13410 ENOG4105CIC tryptophan-specific transport protein WM43_13415 ENOG4105C6K Malic enzyme WM43_13420 ENOG4107S2Z UPF0761 membrane protein WM43_13425 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) WM43_13430 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) WM43_13435 ENOG4105SUU thioesterase domain WM43_13445 ENOG4105CB5 ATP-dependent DNA helicase recG WM43_13450 ENOG4105JIM Phosphatidylserine synthase WM43_13455 ENOG4105C6Z Gluconate WM43_13460 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family WM43_13465 ENOG4105C01 Dihydroxy-acid dehydratase WM43_13470 ENOG4108UHU Aldolase WM43_13475 ENOG4105DIQ Transcriptional regulator WM43_13485 ENOG41063SB peptidase WM43_13490 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) WM43_13495 ENOG4107YZP Rhodanese domain protein WM43_13500 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) WM43_13505 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase WM43_13510 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) WM43_13515 ENOG4105MJ2 Competence protein WM43_13520 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WM43_13540 ENOG4105BZM domain protein WM43_13545 ENOG4108RRZ Transcription elongation factor GreB WM43_13550 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WM43_13555 ENOG4105E0F Histidine kinase WM43_13565 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) WM43_13570 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) WM43_13575 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) WM43_13580 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) WM43_13585 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity WM43_13590 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) WM43_13595 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) WM43_13600 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) WM43_13605 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) WM43_13610 ENOG41083MP 50s ribosomal protein l29 WM43_13615 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal WM43_13620 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) WM43_13625 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) WM43_13630 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits WM43_13635 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) WM43_13640 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) WM43_13645 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) WM43_13650 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) WM43_13655 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) WM43_13660 ENOG4105VPB 50S ribosomal protein L30 WM43_13665 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) WM43_13670 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) WM43_13675 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits WM43_13680 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) WM43_13685 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) WM43_13690 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) WM43_13695 ENOG4108ZT0 50S ribosomal protein l17 WM43_13725 ENOG4105D05 Receptor WM43_13735 ENOG4105E0F Histidine kinase WM43_13740 ENOG4105DPZ Two component transcriptional regulator (Winged helix family WM43_13755 ENOG4105CWB LysR family transcriptional Regulator WM43_13765 ENOG4105C2I pirin domain protein WM43_13770 ENOG4108VBZ doxx family WM43_13775 ENOG4105DSY exodeoxyribonuclease V, gamma WM43_13780 ENOG4107QKA exodeoxyribonuclease V beta WM43_13785 ENOG4107QYX exodeoxyribonuclease v alpha WM43_13795 ENOG410600T transposase WM43_13805 ENOG4105BZU Histidine kinase WM43_13835 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component WM43_13845 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) WM43_13875 ENOG4108IQK o-acetylhomoserine WM43_13880 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) WM43_13885 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) WM43_13905 ENOG4107IFA Lipase (EC 3.1.1.3) WM43_13910 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) WM43_13915 ENOG4108UDW Transcriptional regulator, luxr family WM43_13935 ENOG4105CH6 catalase WM43_13965 ENOG4105MYG DNA polymerase iii, chi subunit WM43_13970 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) WM43_13975 ENOG4108M8S permease YjgP YjgQ family protein WM43_13980 ENOG4108K5H permease YjgP YjgQ family protein WM43_13995 ENOG4105VTR Integrase WM43_14025 ENOG41061WM D-Alanyl-D-Alanine WM43_14030 ENOG4107SC7 Inner membrane transporter yjeM WM43_14050 ENOG4105CBT Fructose-1,6-bisphosphatase WM43_14065 ENOG4105ECF c-methyltransferase WM43_14070 ENOG41076E6 Uroporphyrinogen-III Synthase WM43_14075 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) WM43_14080 ENOG4107T0K Adenylate cyclase WM43_14085 ENOG4106CJB Phospholipase Carboxylesterase WM43_14090 ENOG4105XQ6 frataxin-like protein WM43_14095 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) WM43_14100 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) WM43_14110 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WM43_14115 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant WM43_14125 ENOG4107RYR Transcriptional regulator, Crp Fnr family WM43_14135 ENOG4108Z86 Glutamine amidotransferase WM43_14140 ENOG4105N42 UPF0307 protein WM43_14160 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WM43_14210 ENOG4108MVM Transposase WM43_14215 ENOG4108ZQS transposase WM43_14255 ENOG4105CMS peptidase U62, modulator of DNA gyrase WM43_14260 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) WM43_14265 ENOG4105VFK BolA family WM43_14275 ENOG4105E3I toluene tolerance WM43_14280 ENOG4107PE3 Mammalian cell entry related domain protein WM43_14285 ENOG4105CY3 ABC transporter, permease WM43_14290 ENOG4105DHJ ABC, transporter WM43_14295 ENOG4105C2X Arabinose 5-phosphate isomerase WM43_14300 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase WM43_14305 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) WM43_14310 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA WM43_14315 ENOG4108IUZ ABC transporter WM43_14320 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WM43_14325 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA WM43_14330 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN WM43_14335 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) WM43_14340 ENOG41080Z8 PHOSPHOCARRIER protein WM43_14360 ENOG41069H0 dihydroorotase EC 3.5.2.3 WM43_14390 ENOG4105C0H protease WM43_14395 ENOG4105C0H protease WM43_14405 ENOG4105D6Z AFG1 family ATPase WM43_14410 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) WM43_14415 ENOG4108UJD 30S ribosomal protein S9 WM43_14420 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WM43_14425 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) WM43_14430 ENOG4105EIX cytochrome c1 WM43_14435 ENOG4107MKT Stringent starvation protein a WM43_14440 ENOG4105KB2 stringent starvation protein b WM43_14445 ENOG4105W4M Transport-associated protein WM43_14450 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) WM43_14455 ENOG41082RQ UPF0102 protein WM43_14460 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) WM43_14465 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) WM43_14475 ENOG4108V6E Cell division protein mraZ WM43_14480 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) WM43_14485 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WM43_14490 ENOG4105CJN penicillin-binding protein WM43_14495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) WM43_14500 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) WM43_14505 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) WM43_14510 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) WM43_14515 ENOG4105CNI cell division protein FtsW WM43_14520 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) WM43_14525 ENOG4105DFU Cell wall formation (By similarity) WM43_14530 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) WM43_14535 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) WM43_14540 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) WM43_14545 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) WM43_14555 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving WM43_14560 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) WM43_14565 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) WM43_14570 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) WM43_14580 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) WM43_14585 ENOG4105D7Q type ii secretion system WM43_14590 ENOG4107QHF type ii secretion system protein e WM43_14600 ENOG410600T transposase WM43_14605 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase WM43_14620 ENOG41073TP transcriptional regulator WM43_14625 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) WM43_14630 ENOG4107QSN dihydrolipoamide acetyltransferase WM43_14635 ENOG4107QN2 dihydrolipoyl dehydrogenase WM43_14640 ENOG4105BZU Histidine kinase WM43_14645 ENOG4108N3W hemolysin secretion protein WM43_14650 ENOG4105D78 K07001 NTE family protein WM43_14655 ENOG4107QIJ Aconitate hydratase 2 WM43_14660 ENOG4105BZU Histidine kinase WM43_14670 ENOG4105CKI cobalamin synthesis protein WM43_14675 ENOG4108IJF Heavy metal efflux pump, CzcA WM43_14690 ENOG4105C0R drug resistance transporter emrb qaca subfamily WM43_14700 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WM43_14705 ENOG4107ZVW dihydroneopterin aldolase WM43_14710 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) WM43_14735 ENOG4105DWD nucleoside recognition domain protein WM43_14745 ENOG4105F2I Transposase WM43_14760 ENOG4105CH7 arginosuccinase WM43_14765 ENOG4105CDH Citrulline--aspartate ligase WM43_14775 ENOG4105CAS nag kinase WM43_14780 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase WM43_14790 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) WM43_14795 ENOG4105EQK -acetyltransferase WM43_14810 ENOG4105C44 Serine transporter WM43_14815 ENOG4108TPP exopolysaccharide synthesis WM43_14825 ENOG4105BZU Histidine kinase WM43_14830 ENOG4105BZU Histidine kinase WM43_14835 ENOG4108XTF Outer Membrane Lipoprotein WM43_14840 ENOG4108R6G acetyltransferase WM43_14845 ENOG4105VXR cytoplasmic protein WM43_14860 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase WM43_14865 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) WM43_14870 ENOG4105VEJ Heat shock protein WM43_14880 ENOG410841Q phosphoesterase PA-phosphatase related protein WM43_14885 ENOG4105IPI Membrane WM43_14905 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family WM43_14915 ENOG4105VDH Dihydroxyacetone kinase WM43_14920 ENOG4108UTZ Dihydroxyacetone kinase WM43_14925 ENOG4105CMT Dihydroxyacetone kinase WM43_14930 ENOG4105C7N Xanthine uracil vitamin C permease WM43_14935 ENOG4105VEQ Cold shock protein WM43_14955 ENOG4105F2I Transposase WM43_14965 ENOG4105F5W AtP-binding protein WM43_14970 ENOG4105D70 Integrase catalytic subunit WM43_14980 ENOG410600T transposase WM43_15005 ENOG4108MVM Transposase WM43_15010 ENOG4108ZQS transposase WM43_15020 ENOG4108FPN Integrase WM43_15035 ENOG4108IMY Transcriptional regulator WM43_15070 ENOG4105C7H Helicase, RecD TraA family WM43_15095 ENOG4108UUM single-stranded DNA-binding protein WM43_15100 ENOG41086KC Transcriptional regulator WM43_15105 ENOG4108XDW curli assembly protein CsgE WM43_15115 ENOG4105P8Q Curli production assembly transport component CsgG WM43_15120 ENOG4105VNT transposase (IS4 family) protein WM43_15140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) WM43_15145 ENOG4105BZU Histidine kinase WM43_15150 ENOG4105EIF outer membrane protein W WM43_15155 ENOG4105C8Q Methyl-accepting chemotaxis WM43_15165 ENOG4105VNT transposase (IS4 family) protein WM43_15175 ENOG4105SYT Methylenetetrahydrofolate reductase WM43_15185 ENOG4105DKK Benzoate WM43_15190 ENOG4108JCI Transcriptional regulator WM43_15230 ENOG41090HJ UPF0265 protein WM43_15240 ENOG410667J hydrolase WM43_15250 ENOG4108I62 cina-like protein WM43_15260 ENOG4105CVG Homoserine O-transsuccinylase WM43_15270 ENOG4108YXU transcriptional regulator AsnC family WM43_15275 ENOG4105E0M Sulfatase WM43_15310 ENOG4105EMU Dehydrogenase WM43_15315 ENOG4105DZW Dipeptidase WM43_15325 ENOG4108I6A alcohol dehydrogenase WM43_15330 ENOG4108Z5K methylglyoxal synthase WM43_15340 ENOG4108UQY Iron-storage protein WM43_15355 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) WM43_15360 ENOG410904N short-chain dehydrogenase reductase WM43_15365 ENOG4107R88 Chemotaxis protein (CheV) WM43_15380 ENOG4107GZ4 SanA protein WM43_15385 ENOG4107MM9 BNR Asp-box repeat-containing protein WM43_15390 ENOG4108MVM Transposase WM43_15395 ENOG4108ZQS transposase WM43_15400 ENOG4105F2I Transposase WM43_15410 ENOG4105CEY Amp-dependent synthetase and ligase WM43_15415 ENOG4105DNI Converts SHCHC to OSB (By similarity) WM43_15420 ENOG4108IPT Naphthoate synthase WM43_15425 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) WM43_15430 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) WM43_15435 ENOG4105E4F Isochorismate synthase WM43_15440 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase WM43_15460 ENOG4105C1J atp-dependent rna helicase WM43_15465 ENOG4105D9N nucleoside WM43_15470 ENOG4107K5X Membrane-bound metal-dependent hydrolase WM43_15475 ENOG4108UPT UPF0178 protein WM43_15495 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WM43_15500 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) WM43_15505 ENOG4105E61 Mannitol repressor protein WM43_15510 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase WM43_15515 ENOG4105CTS PTS system mannitol-specific WM43_15520 ENOG4105D1S lipid A biosynthesis WM43_15525 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) WM43_15530 ENOG4105DFG type I secretion outer membrane protein WM43_15535 ENOG41087AY ADP-Ribose pyrophosphatase WM43_15540 ENOG4108SX3 cytoplasmic protein WM43_15545 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) WM43_15550 ENOG4105IPS esterase WM43_15565 ENOG4105Y49 secretion protein, HlyD family WM43_15570 ENOG4105DSW Fusaric acid resistance protein WM43_15575 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WM43_15580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) WM43_15600 ENOG4105CBN LysR family transcriptional regulator WM43_15610 ENOG4105DUX Transporter WM43_15630 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) WM43_15635 ENOG4107EXU Short-chain dehydrogenase reductase Sdr WM43_15645 ENOG4105C5Q Transcriptional regulator WM43_15650 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen WM43_15670 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase WM43_15675 ENOG41087YS Phage shock protein A WM43_15690 ENOG41082IR Excinuclease ABC C subunit domain protein WM43_15705 ENOG4108RG0 uracil-dna glycosylase WM43_15710 ENOG4105DFI Membrane WM43_15715 ENOG4105ETT transcriptional Regulator, LysR family WM43_15720 ENOG4105FAV ABC, transporter WM43_15725 ENOG4105FDK ABC transporter WM43_15730 ENOG4105NXV High-affinity zinc uptake system protein WM43_15750 ENOG4105DR5 peptidase WM43_15760 ENOG4105R2J Conserved Protein WM43_15780 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate WM43_15785 ENOG4105CEN a g-specific adenine glycosylase WM43_15790 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) WM43_15800 ENOG4105H4F exported protein WM43_15810 ENOG4105UYK outer membrane protein a WM43_15815 ENOG4106TD9 Diguanylate cyclase WM43_15820 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) WM43_15825 ENOG4105C2N RNA methyltransferase TrmH family group 3 WM43_15835 ENOG4107YB6 acetyltransferase, (GNAT) family WM43_15840 ENOG4105C1J atp-dependent rna helicase WM43_15845 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) WM43_15850 ENOG4105CWM branched-chain amino acid transport system II carrier protein WM43_15855 ENOG4105CWM branched-chain amino acid transport system II carrier protein WM43_15875 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) WM43_15880 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WM43_15890 ENOG4107QSI ABC, transporter WM43_15900 ENOG4105EQK -acetyltransferase WM43_15905 ENOG4106WH9 Protein of unknown function (DUF2753) WM43_15910 ENOG4105E39 Enoyl-CoA hydratase WM43_15925 ENOG4108RZ4 Short-chain dehydrogenase reductase Sdr WM43_15930 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) WM43_15935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WM43_15945 ENOG4105DY2 Paraquat-inducible protein b WM43_15950 ENOG4105F1S paraquat-inducible protein a WM43_15955 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) WM43_15960 ENOG4107VXZ Hydrolase WM43_15975 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) WM43_15980 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) WM43_15985 ENOG4105NNS Autoinducer synthesis protein WM43_15990 ENOG4105VJY transcriptional regulator WM43_15995 ENOG4108ZUB Lysine exporter protein (Lyse ygga) WM43_16000 ENOG4105C8Q Methyl-accepting chemotaxis WM43_16005 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) WM43_16010 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) WM43_16015 ENOG4105C4M (Ubiquinol oxidase) subunit I WM43_16020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii WM43_16035 ENOG4107YD3 Thioesterase WM43_16040 ENOG4105E02 MotA TolQ exbB proton channel WM43_16045 ENOG4105M8F Biopolymer transport protein exbD tolR WM43_16055 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) WM43_16060 ENOG4105KCK Peptidoglycan-associated lipoprotein WM43_16065 ENOG4105UFD tol-pal system protein YbgF WM43_16130 ENOG4105C8J )-transporter WM43_16140 ENOG4105C8J )-transporter WM43_16155 ENOG4108K4B hydrolase WM43_16170 ENOG4105EW9 transcriptional regulator AsnC family WM43_16195 ENOG4105E0X reductase WM43_16205 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) WM43_16210 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) WM43_16220 ENOG4105DSB aldose 1-epimerase WM43_16225 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) WM43_16230 ENOG4105C8Q Methyl-accepting chemotaxis WM43_16235 ENOG4105G5H Membrane WM43_16240 ENOG4107QX8 SPFH domain, Band 7 family protein WM43_16245 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) WM43_16250 ENOG4105C11 sulfate adenylyltransferase), subunit 2 WM43_16255 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) WM43_16265 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) WM43_16290 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WM43_16325 ENOG4108UUE Transcriptional regulator WM43_16340 ENOG4105F0N pyrophosphate phospho-hydrolase WM43_16345 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_16355 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) WM43_16360 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) WM43_16365 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase WM43_16370 ENOG4105BZ4 penicillin-binding protein WM43_16375 ENOG4105CQ7 ATP-dependent helicase WM43_16385 ENOG4105PW4 Sugar fermentation stimulation protein homolog WM43_16390 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters WM43_16395 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) WM43_16400 ENOG4105DJ0 Poly(A) Polymerase WM43_16405 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase WM43_16410 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) WM43_16415 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) WM43_16425 ENOG4108ETY sodium dicarboxylate symporter WM43_16445 ENOG4105CIZ coA-substrate-specific enzyme activase WM43_16450 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase WM43_16455 ENOG4105E3A (ABC) transporter WM43_16460 ENOG4105DA5 (ABC) transporter WM43_16465 ENOG4108UGV hypoxanthine phosphoribosyltransferase WM43_16470 ENOG410630P Transcriptional regulator WM43_16475 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase WM43_16480 ENOG4105DFU Cell wall formation (By similarity) WM43_16485 ENOG41076MN Phosphoesterase, PA-phosphatase related WM43_16490 ENOG4105CMR udp-glucose 4-epimerase WM43_16495 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) WM43_16500 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) WM43_16505 ENOG4108RMU ferritin dps family protein WM43_16510 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase WM43_16515 ENOG4108W15 Protein of unknown function (DUF1456) WM43_16520 ENOG4105BZU Histidine kinase WM43_16525 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) WM43_16530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) WM43_16535 ENOG4105DXN mazG family WM43_16540 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) WM43_16545 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) WM43_16560 ENOG4105F2I Transposase WM43_16570 ENOG4105F2I Transposase WM43_16595 ENOG4105D6S protein involved in catabolism of external DNA WM43_16605 ENOG4105C5H ABC transporter WM43_16625 ENOG4107SQD Transcriptional regulator, GntR family WM43_16650 ENOG4105XEP YhcH YjgK YiaL family protein WM43_16660 ENOG4105CUY Mechanosensitive ion channel WM43_16665 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WM43_16675 ENOG4105CK7 Sodium proline symporter WM43_16680 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) WM43_16685 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) WM43_16690 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) WM43_16695 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) WM43_16700 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) WM43_16705 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) WM43_16710 ENOG4108UM1 dedA family WM43_16715 ENOG4108K5P (LipO)protein WM43_16725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase WM43_16745 ENOG4105DWY Agmatine deiminase WM43_16750 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) WM43_16760 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) WM43_16770 ENOG4105C1J atp-dependent rna helicase WM43_16775 ENOG4105BZU Histidine kinase WM43_16785 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase WM43_16790 ENOG4105CA0 peroxidase WM43_16810 ENOG4107QWG 2-Nitropropane dioxygenase WM43_16870 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) WM43_16880 ENOG4108NVR Methyl-accepting chemotaxis WM43_16885 ENOG4105EYW Ion transport protein WM43_16890 ENOG4106MWK domain protein WM43_16895 ENOG4105C26 Dehydrogenase WM43_16905 ENOG4105E09 nadh pyrophosphatase WM43_16910 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) WM43_16915 ENOG4105DKQ ROK family WM43_16920 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase WM43_16925 ENOG4105BZA Phosphoglycerate kinase WM43_16930 ENOG4105D2N Aldolase WM43_16935 ENOG4105CJP fad dependent oxidoreductase WM43_16950 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) WM43_16975 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) WM43_16980 ENOG4105Y75 tpr repeat protein WM43_16990 ENOG4108IYU L-aspartate oxidase WM43_16995 ENOG4105EMN RNA polymerase sigma factor WM43_17000 ENOG41069PW sigma-e factor negative regulatory protein WM43_17005 ENOG4105VQK sigma E regulatory protein, MucB RseB WM43_17015 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) WM43_17020 ENOG4105C3F Signal peptidase i WM43_17025 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) WM43_17035 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) WM43_17040 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) WM43_17045 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase WM43_17050 ENOG4105K9H YciI-like protein WM43_17055 ENOG4107835 probably involved in intracellular septation (By similarity) WM43_17060 ENOG4105DY8 decarboxylase WM43_17065 ENOG4108UT2 hemolysin iii WM43_17070 ENOG4105D0C transport protein WM43_17085 ENOG4105BZU Histidine kinase WM43_17090 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) WM43_17115 ENOG4105CA0 peroxidase WM43_17125 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) WM43_17130 ENOG4105DD7 kinase (PfkB family WM43_17160 ENOG4108MVM Transposase WM43_17165 ENOG4108ZQS transposase WM43_17175 ENOG4107RYR Transcriptional regulator, Crp Fnr family WM43_17180 ENOG4108UKZ OsmC family WM43_17195 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) WM43_17200 ENOG4105YP7 UPF0270 protein WM43_17210 ENOG4105DNZ Alpha Beta Hydrolase WM43_17215 ENOG4107R88 Chemotaxis protein (CheV) WM43_17225 ENOG4105VKU nucleicacid-binding protein WM43_17230 ENOG4108YZY peptidylprolyl cis-trans isomerase WM43_17245 ENOG4105CDU Replicative dna helicase WM43_17250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WM43_17255 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme WM43_17260 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) WM43_17275 ENOG4105EHG Permease protein WM43_17285 ENOG41090JE Utilization Protein WM43_17290 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related WM43_17315 ENOG4105D8G Major Facilitator superfamily WM43_17325 ENOG4105VMP Transcriptional regulator WM43_17335 ENOG4105BZU Histidine kinase WM43_17345 ENOG4105BZU Histidine kinase WM43_17355 ENOG4108MA4 Peptidase M66 WM43_17360 ENOG4108M1A Chitin-binding protein WM43_17400 ENOG4107R88 Chemotaxis protein (CheV) WM43_17405 ENOG4108UJV acyl-CoA thioesterase i WM43_17410 ENOG4108I0Y (ABC) transporter WM43_17415 ENOG4105CV6 ABC transporter, permease WM43_17420 ENOG4105ECP epimerase WM43_17425 ENOG4105BZU Histidine kinase WM43_17430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family WM43_17435 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) WM43_17440 ENOG41090ED Protein with unknown function (DUF469) WM43_17445 ENOG4105CSV Glutaminase WM43_17450 ENOG4107RM6 sulfurtransferase WM43_17455 ENOG4105SUV lipoprotein YgdR WM43_17465 ENOG4108RIR Molybdenum cofactor biosynthesis protein WM43_17475 ENOG4105DWK Membrane WM43_17480 ENOG4107XM3 UPF0442 protein WM43_17490 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) WM43_17495 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) WM43_17500 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) WM43_17505 ENOG4105CRK lysyL-tRNA synthetase WM43_17510 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) WM43_17515 ENOG4105C8Q Methyl-accepting chemotaxis WM43_17520 ENOG4105D6U Sodium Glutamate Symporter WM43_17525 ENOG4105HDK L-asparaginase WM43_17530 ENOG4105VUT cytoplasmic protein WM43_17550 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) WM43_17555 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) WM43_17560 ENOG4108Z43 UPF0250 protein WM43_17565 ENOG4105DZ1 carboxypeptidase WM43_17570 ENOG4105K6T rare lipoprotein A WM43_17575 ENOG4105CVE Lytic murein transglycosylase WM43_17580 ENOG4105CNI cell division protein FtsW WM43_17585 ENOG4105CJN penicillin-binding protein WM43_17590 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) WM43_17595 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) WM43_17600 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) WM43_17615 ENOG4105C8T Leucyl-tRNA synthetase WM43_17620 ENOG4107PAI alpha helical protein WM43_17635 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) WM43_17640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WM43_17650 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) WM43_17660 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) WM43_17665 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) WM43_17670 ENOG4108JU5 Magnesium and cobalt efflux protein WM43_17675 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) WM43_17680 ENOG4105C9A Phoh family WM43_17685 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) WM43_17690 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WM43_17695 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) WM43_17700 ENOG4105BZU Histidine kinase WM43_17705 ENOG4106KR7 LysR family Transcriptional regulator WM43_17730 ENOG4105C5I Dehydrogenase WM43_17740 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) WM43_17750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) WM43_17760 ENOG4105DHQ Histidine kinase WM43_17765 ENOG4105XJC Two component transcriptional regulator (Winged helix family WM43_17775 ENOG4105EMU Dehydrogenase WM43_17800 ENOG4105CJP fad dependent oxidoreductase WM43_17815 ENOG4105T0Z Conserved Protein WM43_17825 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WM43_17830 ENOG4108P2H Inner membrane protein YjiG WM43_17835 ENOG41074DU domain protein WM43_17840 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) WM43_17845 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) WM43_17850 ENOG4105E33 succinate dehydrogenase WM43_17860 ENOG4105C8Q Methyl-accepting chemotaxis WM43_17865 ENOG4108QXE glycerophosphoryl diester phosphodiesterase WM43_17870 ENOG4105EGS Mechanosensitive ion channel WM43_17880 ENOG4105DR5 peptidase WM43_17890 ENOG4105EJC lysr family transcriptional regulator WM43_17905 ENOG4108NVR Methyl-accepting chemotaxis WM43_17910 ENOG4105C5Q Transcriptional regulator WM43_17915 ENOG4108JQC penicillin-binding protein 1A WM43_17940 ENOG4105E4G Type IV pilus WM43_17945 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) WM43_17950 ENOG4105D49 3-dehydroquinate synthase WM43_17960 ENOG4105DFE Dna adenine methylase WM43_17965 ENOG4105DJV ribulose-phosphate 3-epimerase WM43_17970 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) WM43_17975 ENOG4105C31 Tryptophanyl-tRNA synthetase WM43_17990 ENOG4105C8Y Acetylornithine aminotransferase WM43_18000 ENOG4105C26 Dehydrogenase WM43_18015 ENOG4107VXZ Hydrolase WM43_18025 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) WM43_18030 ENOG4105CG3 alpha amylase, catalytic region WM43_18040 ENOG41060QA UPF0267 protein WM43_18050 ENOG4108I5U Uridine phosphorylase WM43_18055 ENOG4106Z1T Nicotinamide Mononucleotide Transporter WM43_18060 ENOG4107QWE )-transporter WM43_18105 ENOG4105C3G gtp-binding protein WM43_18110 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) WM43_18115 ENOG4105CGH 5'-nucleotidase WM43_18120 ENOG4105C5T Phosphoribosyl pyrophosphate synthase WM43_18130 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) WM43_18135 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) WM43_18140 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) WM43_18145 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) WM43_18150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) WM43_18160 ENOG41063JG Transcriptional regulator WM43_18165 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase WM43_18170 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) WM43_18175 ENOG4105F2I Transposase WM43_18185 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) WM43_18195 ENOG4107WCA isomerase WM43_18205 ENOG4108V1U phospholipid-binding protein WM43_18210 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis WM43_18225 ENOG4105C87 Aminotransferase class I and II WM43_18235 ENOG4105C5Q Transcriptional regulator WM43_18240 ENOG4105UBK short-chain dehydrogenase reductase WM43_18245 ENOG4105ERU peptidase WM43_18250 ENOG4105E5W Transporter WM43_18255 ENOG4105BZU Histidine kinase WM43_18260 ENOG41090EX DsrE family WM43_18270 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding WM43_18275 ENOG4105CFP Peptidase U32 WM43_18300 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) WM43_18305 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WM43_18315 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WM43_18320 ENOG4105E2D ec 3.2.1.52 WM43_18325 ENOG4105RD7 BadF BadG BcrA BcrD WM43_18335 ENOG4108JQ7 (ABC) transporter WM43_18345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WM43_18360 ENOG4105BZU Histidine kinase WM43_18380 ENOG4105XIQ Protein of unknown function (DUF2517) WM43_18410 ENOG4107SDU Methyl-accepting chemotaxis WM43_18420 ENOG4108ESY Metal dependent phosphohydrolase WM43_18425 ENOG4105DR8 Membrane WM43_18430 ENOG4105CVM Molybdenum cofactor synthesis domain protein WM43_18435 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) WM43_18440 ENOG4108IUZ ABC transporter WM43_18445 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component WM43_18455 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family WM43_18460 ENOG4105BZU Histidine kinase WM43_18470 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) WM43_18475 ENOG4105F2I Transposase WM43_18505 ENOG4108IEG Formate dehydrogenase Alpha subunit WM43_18505 ENOG4108IEG Formate dehydrogenase Alpha subunit WM43_18510 ENOG4105QAX Iron-sulfur WM43_18530 ENOG4107R1I NAD-dependent malic enzyme WM43_18545 ENOG4105C2W permease WM43_18550 ENOG4106TNF Periplasmic binding protein WM43_18555 ENOG4108NVR Methyl-accepting chemotaxis WM43_18580 ENOG4105CHC glucokinase (EC 2.7.1.2) WM43_18585 ENOG4106KNT transcriptional regulator WM43_18590 ENOG4105CA9 Pyruvate kinase WM43_18610 ENOG4105VQ0 flagellar hook-basal body complex protein fliE WM43_18615 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) WM43_18620 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WM43_18630 ENOG4108JIR Flagellum-specific ATP synthase WM43_18650 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) WM43_18655 ENOG4105DD5 Flagellar motor switch protein WM43_18660 ENOG4105VTB flagellar biosynthesis protein fliO WM43_18665 ENOG4105CN7 Flagellar biosynthetic protein FliP WM43_18670 ENOG4105VS8 Flagellar biosynthetic protein fliq WM43_18675 ENOG4105D19 Role in flagellar biosynthesis (By similarity) WM43_18680 ENOG4105D00 flagellar biosynthetic protein flhB WM43_18685 ENOG4105D7B Flagellar biosynthesis protein flha WM43_18690 ENOG4105FZW flagellar biosynthesis regulator FlhF WM43_18700 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) WM43_18705 ENOG4108VYJ response regulator receiver protein WM43_18710 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) WM43_18715 ENOG4105CBS Chea signal transduction histidine kinase WM43_18720 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) WM43_18725 ENOG4105E14 MotA TolQ exbB proton channel WM43_18730 ENOG4108SEK ompa motb domain protein WM43_18735 ENOG4107QJE Chromosome Partitioning Protein WM43_18745 ENOG4108V3W Chemotaxis protein, CheW WM43_18760 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) WM43_18765 ENOG41060IM Heme exporter protein WM43_18770 ENOG4105X3C heme exporter protein WM43_18775 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) WM43_18780 ENOG4105DA4 cytochrome c-type biogenesis protein WM43_18785 ENOG4107QX9 Thiol disulfide interChange protein WM43_18790 ENOG4105KWW Biogenesis protein WM43_18800 ENOG410903C (LipO)protein WM43_18805 ENOG4105VNT transposase (IS4 family) protein WM43_18810 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) WM43_18815 ENOG4105M2J Glutaredoxin WM43_18825 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) WM43_18830 ENOG4105C7B Threonine dehydratase WM43_18840 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) WM43_18845 ENOG4105C6N Formate acetyltransferase WM43_18850 ENOG4105KME endoribonuclease L-psp WM43_18875 ENOG410600T transposase WM43_18885 ENOG4108ZQS transposase WM43_18890 ENOG4108MVM Transposase WM43_18900 ENOG4105F2I Transposase WM43_18910 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) WM43_18915 ENOG4108TGY Glutathione S-transferase WM43_18935 ENOG4105EZE Cupin 4 family protein WM43_18940 ENOG4107QTF adenylosuccinate lyase WM43_18945 ENOG41075W9 High frequency lysogenization protein HflD homolog WM43_18950 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) WM43_18960 ENOG4108R99 pseudouridine synthase WM43_18970 ENOG4108YRF PTS System WM43_18975 ENOG4105CXY transporter WM43_18980 ENOG4105DM4 PTS System WM43_19000 ENOG4105F2I Transposase WM43_19010 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) WM43_19020 ENOG4105BZS acriflavin resistance protein WM43_19025 ENOG4107QPN acyl-Coa dehydrogenase WM43_19035 ENOG4107SSZ Phosphatase WM43_19045 ENOG4108JB9 formate dehydrogenase WM43_19050 ENOG4105BZU Histidine kinase WM43_19055 ENOG4105BZU Histidine kinase WM43_19065 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) WM43_19070 ENOG4108Z1B Cyclase dehydrase WM43_19075 ENOG4105VDB UPF0125 protein WM43_19080 ENOG4105CH2 amidohydrolase WM43_19085 ENOG4107QPN acyl-Coa dehydrogenase WM43_19090 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) WM43_19095 ENOG4105E7A Glutamine amidotransferase WM43_19105 ENOG4105CHW UPF0052 protein WM43_19125 ENOG4105WH1 Two component transcriptional regulator luxr family WM43_19130 ENOG4105BZU Histidine kinase WM43_19135 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WM43_19150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) WM43_19155 ENOG4108BGM Quinol dehydrogenase periplasmic component WM43_19160 ENOG4105GXZ Ferredoxin-type protein NapH WM43_19170 ENOG4105CUW cytochrome C-TYPE protein WM43_19175 ENOG4108RIR Molybdenum cofactor biosynthesis protein WM43_19180 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) WM43_19185 ENOG4105M00 molybdopterin converting factor, subunit 1 WM43_19190 ENOG4108ZAF Molybdopterin WM43_19195 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein WM43_19200 ENOG4105E0C molybdate abc transporter WM43_19205 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) WM43_19210 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) WM43_19215 ENOG4105D06 uba thif-type nad fad binding protein WM43_19220 ENOG4105CVM Molybdenum cofactor synthesis domain protein WM43_19225 ENOG4105EUJ GTP cyclohydrolase i WM43_19230 ENOG4105C8Q Methyl-accepting chemotaxis WM43_19235 ENOG4105CKU formyltetrahydrofolate synthetase WM43_19245 ENOG4105CC0 LysR family Transcriptional regulator WM43_19250 ENOG4108YYC ycei family WM43_19260 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) WM43_19275 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) WM43_19280 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) WM43_19290 ENOG4105EUZ Beta-lactamase domain protein WM43_19310 ENOG4105C44 Serine transporter WM43_19315 ENOG4105KME endoribonuclease L-psp WM43_19320 ENOG4105CEM UPF0597 protein WM43_19325 ENOG4105WWK YheO domain protein WM43_19340 ENOG4105RKW reductase (By WM43_19345 ENOG4105CSX c4-dicarboxylate anaerobic carrier WM43_19350 ENOG4105CHM Aminotransferase WM43_19360 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) WM43_19365 ENOG4105E4C Lytic transglycosylase catalytic WM43_19380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WM43_19390 ENOG4105CIY formyltetrahydrofolate deformylase WM43_19395 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) WM43_19405 ENOG4105K63 Thioredoxin WM43_19410 ENOG4107YAK holo-(acyl carrier protein) synthase 2 WM43_19415 ENOG4107TT5 NLP P60 protein WM43_19420 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) WM43_19430 ENOG4105C8P )-transporter WM43_19440 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein WM43_19455 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) WM43_19470 ENOG4105E9H Lytic Murein transglycosylase WM43_19475 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) WM43_19480 ENOG4105D1A Methyltransferase WM43_19485 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) WM43_19490 ENOG4107RZZ dna polymerase iii epsilon subunit WM43_19505 ENOG4105Q26 Siderophore-interacting protein WM43_19510 ENOG4105D05 Receptor WM43_19515 ENOG4105DQ5 transport system permease protein WM43_19520 ENOG4105TVJ transport system, permease WM43_19525 ENOG4105E0A ABC, transporter WM43_19530 ENOG4105S10 periplasmic binding protein WM43_19540 ENOG4108IJF Heavy metal efflux pump, CzcA WM43_19545 ENOG4105EP1 Efflux transporter rnd family, mfp subunit WM43_19555 ENOG4105ISI outer membrane protein, OMPP1 FadL TodX family WM43_19580 ENOG4105CGK Exodeoxyribonuclease III WM43_19610 ENOG4108YXG UPF0502 protein WM43_19615 ENOG4105BZU Histidine kinase WM43_19625 ENOG4105Z2P Protein of unknown function (DUF465) WM43_19635 ENOG4105UQX Mate efflux family protein WM43_19655 ENOG4105C0A alcohol dehydrogenase WM43_19665 ENOG4107Z3H Transcriptional regulator, TetR family WM43_19670 ENOG4107RGH Aldehyde dehydrogenase WM43_19700 ENOG4105KAF membrAne WM43_19720 ENOG4105CHH sulfate transporter WM43_19725 ENOG4105DM4 PTS System WM43_19735 ENOG4105C8Q Methyl-accepting chemotaxis WM43_19740 ENOG4105EIP mannose-6-phosphate isomerase WM43_19745 ENOG4106R3P AraC family transcriptional regulator WM43_19750 ENOG4108HMX isocitrate dehydrogenase (NADP) WM43_19755 ENOG4105W8I Transcriptional regulator WM43_19760 ENOG4108QBX (LipO)protein WM43_19765 ENOG4105C5Q Transcriptional regulator WM43_19770 ENOG4105D3R alkyl hydroperoxide reductase WM43_19790 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) WM43_19795 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) WM43_19800 ENOG41081XQ Conserved Protein WM43_19805 ENOG4105C9M aspartyl-trna synthetase WM43_19810 ENOG4105CDY transcriptional regulatory protein WM43_19815 ENOG4108EKI Dehydrogenase WM43_19820 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein WM43_19825 ENOG4107QSI ABC, transporter WM43_19830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component WM43_19835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component WM43_19840 ENOG4105C3U ABC transporter WM43_19845 ENOG4108JQ7 (ABC) transporter WM43_19850 ENOG4105DU1 integral membrane protein, terc WM43_19855 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) WM43_19865 ENOG4105CZX twitching motility protein WM43_19880 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) WM43_19885 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) WM43_19890 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WM43_19895 ENOG41080IJ Diacylglycerol kinase WM43_19900 ENOG4108JQ1 Dehydrogenase WM43_19905 ENOG4105E66 phosphoriboisomerase A WM43_19910 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase WM43_19925 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) WM43_19930 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain WM43_19935 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain WM43_19940 ENOG4107QS8 (LipO)protein WM43_19950 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) WM43_19960 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WM43_19965 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WM43_20000 ENOG4105K59 histidine triad (HIT) protein WM43_20005 ENOG4108NVR Methyl-accepting chemotaxis WM43_20015 ENOG4105CD3 dihydroorotase WM43_20030 ENOG4105CK2 sodium dicarboxylate symporter WM43_20035 ENOG4105C8Q Methyl-accepting chemotaxis WM43_20045 ENOG4105CKW Inner membrane protein yedI WM43_20050 ENOG4105DPN Oligoendopeptidase f WM43_20055 ENOG4105C2W permease WM43_20065 ENOG4105CEP NADH dehydrogenase WM43_20075 ENOG4105F1A Pyruvate formate-lyase WM43_20080 ENOG4105BZU Histidine kinase WM43_20085 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase WM43_20095 ENOG4105DN3 alpha-2-macroglobulin domain protein WM43_20100 ENOG4108JQB penicillin-binding protein 1C WM43_20110 ENOG4107R08 Integrase WM43_20180 ENOG41076J9 exonuclease VIII WM43_20235 ENOG4105DVF Cytosine-specific methyltransferase WM43_20440 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) WM43_20450 ENOG4105EN6 Membrane WM43_20455 ENOG4105I03 Flagellin WM43_20460 ENOG41063QE flagellar protein FlaG WM43_20470 ENOG4105MQ3 flagellar protein FliS WM43_20500 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) WM43_20510 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) WM43_20520 ENOG4105VNT transposase (IS4 family) protein WM43_20535 ENOG4105D7V transposase WM43_20545 ENOG4105CYM Glutathione S-transferase WM43_20550 ENOG4105E5M Multidrug resistance protein D WM43_20560 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) WM43_20570 ENOG4105D0A hydroxylase WM43_20575 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family WM43_20580 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) WM43_20585 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) WM43_20590 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor WM43_20610 ENOG4106RHG Yeca family WM43_20615 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) WM43_20625 ENOG4105DZR Type I site-specific deoxyribonuclease WM43_20685 ENOG4105C0D helicase WM43_20695 ENOG4105D70 Integrase catalytic subunit WM43_20700 ENOG4105F5W AtP-binding protein WM43_20705 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor WM43_20725 ENOG4105C85 amino acid WM43_20735 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) WM43_20740 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) WM43_20755 ENOG4105D01 (LipO)protein WM43_20760 ENOG4105E68 Sulfatase WM43_20765 ENOG4105PAN UPF0352 protein WM43_20770 ENOG4106V8H Nucleoid-associated protein WM43_20775 ENOG4107FKK extracellular solute-binding protein family 1 WM43_20780 ENOG4105D56 permease protein WM43_20785 ENOG4105EG2 ABC transporter, permease WM43_20790 ENOG4108IJ9 (ABC) transporter WM43_20795 ENOG4105CSR polyphosphate kinase 2 WM43_20815 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) WM43_20820 ENOG4105ERG peptidase m48, ste24p WM43_20830 ENOG4105K89 arsenate reductase WM43_20840 ENOG4108ZYK Acyl carrier protein phosphodiesterase WM43_20845 ENOG4105DYB Isoaspartyl dipeptidase WM43_20850 ENOG4105DWU Membrane WM43_20855 ENOG4108JEH abc transporter atp-binding protein WM43_20860 ENOG4105E89 ABC transporter WM43_20865 ENOG4105DSP amino acid AbC transporter WM43_20870 ENOG4106YG3 ABC transporter WM43_20880 ENOG4108W1A pseudouridine synthase WM43_20890 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase WM43_20895 ENOG4105F1J Homogentisate 1,2-dioxygenase WM43_20905 ENOG4108RXX maleylacetoacetate isomerase WM43_20930 ENOG4105DHQ Histidine kinase WM43_20935 ENOG4105Y3U Transglycosylase-associated protein WM43_20940 ENOG4108UNC WM43_20945 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) WM43_20955 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) WM43_20970 ENOG410600T transposase WM43_21035 ENOG4108ZJT translation initiation factor, Sui1 WM43_21060 ENOG4105C1J atp-dependent rna helicase WM43_21065 ENOG4105BZ8 glutamate synthase WM43_21070 ENOG4105CBC glutamate synthase WM43_21080 ENOG4105N5T Radical SAM Protein WM43_21085 ENOG4108JJA ABC, transporter WM43_21090 ENOG4105C42 Type I secretion membrane fusion protein (HlyD WM43_21135 ENOG4105D3R alkyl hydroperoxide reductase WM43_21140 ENOG4105W87 Cbs domain WM43_21145 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) WM43_21150 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) WM43_21155 ENOG4105VIE preprotein translocase, subunit YajC WM43_21160 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WM43_21165 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) WM43_21180 ENOG4106RZ4 Peptidase U32 WM43_21185 ENOG4105CFP Peptidase U32 WM43_21190 ENOG4105XPQ lipid carrier protein WM43_21200 ENOG4105CVS RNA methyltransferase TrmH family, group 1 WM43_21205 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family WM43_21210 ENOG4105C3J Cysteine desulfurase WM43_21215 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins WM43_21220 ENOG4108Z4V iron-sulfur cluster assembly WM43_21225 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) WM43_21230 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB WM43_21235 ENOG4108ZIT Ferredoxin, 2FE-2S WM43_21250 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) WM43_21255 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs WM43_21265 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) WM43_21270 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) WM43_21275 ENOG4105CUT histidyl-tRNA synthetase WM43_21280 ENOG4105N21 Membrane WM43_21285 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) WM43_21290 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) WM43_21295 ENOG4105VPD cellular component movement WM43_21300 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) WM43_21305 ENOG4107QIK phosphoribosylformylglycinamidine synthase WM43_21310 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_21315 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_21325 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_21330 ENOG4105C8S subunit m WM43_21335 ENOG4105D65 subunit l WM43_21340 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_21345 ENOG4107UFS subunit j WM43_21350 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_21355 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) WM43_21360 ENOG4108IEH NADH dehydrogenase subunit g WM43_21365 ENOG4107QIZ NADH dehydrogenase WM43_21370 ENOG4105GKE subunit e WM43_21375 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_21380 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) WM43_21385 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain WM43_21405 ENOG4105CUG Oligopeptidase b WM43_21410 ENOG4105D05 Receptor WM43_21415 ENOG4105ER2 Ompa motb domain protein WM43_21420 ENOG4105E14 MotA TolQ exbB proton channel WM43_21425 ENOG4108ZQS transposase WM43_21430 ENOG4108MVM Transposase WM43_21435 ENOG4105E14 MotA TolQ exbB proton channel WM43_21450 ENOG4105HA9 of methanol dehydrogenase type WM43_21460 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) WM43_21465 ENOG4105EZ7 amino acid ABC transporter WM43_21470 ENOG4106TNF Periplasmic binding protein WM43_21475 ENOG4105EAD ABC transporter WM43_21480 ENOG4105CDA abc transporter atp-binding protein WM43_21490 ENOG4105VFU Rna-binding protein WM43_21495 ENOG4107RGM aldo keto reductase WM43_21505 ENOG4108RU0 short-chain dehydrogenase reductase WM43_21520 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase WM43_21525 ENOG4105CBN LysR family transcriptional regulator WM43_21530 ENOG4105BZU Histidine kinase WM43_21535 ENOG4105CFC Transporter WM43_21540 ENOG4108DBC nitroreductase WM43_21555 ENOG4108SC4 )-transporter WM43_21560 ENOG4105DUM transcriptional regulator, lysR family WM43_21565 ENOG4107R11 Transcriptional regulator WM43_21570 ENOG4108JEN Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) WM43_21575 ENOG4105CAT Cytidine monophosphate kinase WM43_21580 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) WM43_21585 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) WM43_21595 ENOG4105CFV Tetratricopeptide repeat protein WM43_21600 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) WM43_21615 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) WM43_21645 ENOG4105XPH Ferredoxin WM43_21755 ENOG4105EQR Transposase IS116 IS110 IS902 WM43_21760 ENOG4105W1Y Transcriptional regulator WM43_21765 ENOG4108VSE mercuric transport protein WM43_21795 ENOG4105BZU Histidine kinase WM43_21830 ENOG4105VUN Transcriptional regulator WM43_21880 ENOG4105EQR Transposase IS116 IS110 IS902 WM43_21920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) WM43_22060 ENOG4105D07 Signal peptide peptidase, SppA WM43_22110 ENOG4105K70 DNA-binding protein WM43_22245 ENOG4105DN3 alpha-2-macroglobulin domain protein WM43_22250 ENOG4105FM1 phage shock protein C WM43_22255 ENOG4105YYT phage shock protein B WM43_22260 ENOG41087YS Phage shock protein A WM43_22265 ENOG4105E51 psp operon transcriptional activator WM43_22275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr WM43_22280 ENOG4108WTK competence damage-inducible protein WM43_22295 ENOG4108YDI single-species biofilm formation on inanimate substrate WM43_22300 ENOG4108J59 Extracellular solute-binding protein, family 5 WM43_22305 ENOG4108I5W peptide transport system, permease protein WM43_22375 ENOG4108J4B Beta-lactamase WM43_22380 ENOG4105MVE transcriptional regulator WM43_22395 ENOG4105FB2 class II Aldolase WM43_22405 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) WM43_22420 ENOG4106QJ6 Integrase catalytic subunit WM43_22490 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) WM43_22505 ENOG4107QJE Chromosome Partitioning Protein WM43_22580 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) WM43_22670 ENOG4105T95 Thiol disulfide interChange protein WM43_22730 ENOG4105GMT ATPase associated with various cellular activities aaa_5 WM43_22740 ENOG4108UUM single-stranded DNA-binding protein