locus-tag	class	description
WM43_00005	COG0602	queuosine metabolic process
WM43_00010	COG3530	Putative quorum-sensing-regulated virulence factor
WM43_00015	COG2096	Adenosyltransferase
WM43_00020	COG2916	Histone family protein nucleoid-structuring protein H-NS
WM43_00025	COG1757	Na H antiporter
WM43_00030	COG1435	thymidine kinase activity
WM43_00075	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WM43_00135	COG2003	Belongs to the UPF0758 family
WM43_00185	COG2916	Histone family protein nucleoid-structuring protein H-NS
WM43_00205	COG0582	viral genome integration into host DNA
WM43_00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WM43_00215	COG0326	Molecular chaperone. Has ATPase activity
WM43_00220	COG4172	Belongs to the ABC transporter superfamily
WM43_00225	COG4172	Belongs to the ABC transporter superfamily
WM43_00230	COG4171	peptide transport system, permease
WM43_00235	COG4168	peptide transport system, permease
WM43_00240	COG0747	negative chemotaxis
WM43_00245	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WM43_00250	COG1842	Phage shock protein A
WM43_00265	COG3106	COG3106 Predicted ATPase
WM43_00270	COG3768	UPF0283 membrane protein
WM43_00275	COG0583	DNA-binding transcription factor activity
WM43_00280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WM43_00285	COG3842	ATPase activity
WM43_00290	COG1176	ABC-type spermidine putrescine transport system, permease component I
WM43_00295	COG1177	transmembrane transport
WM43_00300	COG1012	belongs to the aldehyde dehydrogenase family
WM43_00310	COG2154	pterin-4-alpha-carbinolamine dehydratase
WM43_00325	COG2199	diguanylate cyclase activity
WM43_00330	COG2885	chlorophyll binding
WM43_00335	COG0861	Integral membrane protein TerC family
WM43_00365	COG2910	NAD(P)H-binding
WM43_00370	COG0583	DNA-binding transcription factor activity
WM43_00375	COG0583	DNA-binding transcription factor activity
WM43_00380	COG2271	Major facilitator Superfamily
WM43_00390	COG1335	isochorismatase
WM43_00400	COG0583	DNA-binding transcription factor activity
WM43_00405	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WM43_00415	COG0583	DNA-binding transcription factor activity
WM43_00420	COG2723	6-phospho-beta-galactosidase activity
WM43_00425	COG1944	ATP diphosphatase activity
WM43_00430	COG2116	formate transmembrane transporter activity
WM43_00435	COG1882	Formate acetyltransferase
WM43_00445	COG2983	Belongs to the UPF0260 family
WM43_00460	COG0058	SHG alpha-glucan phosphorylase activity
WM43_00465	COG0471	metal ion transport
WM43_00470	COG3118	belongs to the thioredoxin family
WM43_00480	COG1132	(ABC) transporter
WM43_00485	COG1132	(ABC) transporter
WM43_00495	COG2501	S4 domain
WM43_00510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WM43_00550	COG2009	succinate dehydrogenase
WM43_00555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WM43_00560	COG1053	succinate dehydrogenase
WM43_00570	COG0567	Dehydrogenase, E1 component
WM43_00575	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM43_00580	COG0045	succinate-CoA ligase (ADP-forming) activity
WM43_00600	COG1584	GPR1 FUN34 yaaH family protein
WM43_00630	COG1024	Enoyl-CoA hydratase
WM43_00635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WM43_00640	COG1960	acyl-CoA dehydrogenase activity
WM43_00645	COG1960	acyl-CoA dehydrogenase activity
WM43_00650	COG1024	Enoyl-CoA hydratase
WM43_00655	COG1024	Enoyl-CoA hydratase
WM43_00665	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_00675	COG0730	response to heat
WM43_00705	COG2205	protein histidine kinase activity
WM43_00705	COG0784	Response regulator, receiver
WM43_00745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WM43_00750	COG1215	transferase activity, transferring glycosyl groups
WM43_00755	COG0438	transferase activity, transferring glycosyl groups
WM43_00810	COG0438	transferase activity, transferring glycosyl groups
WM43_00835	COG0438	transferase activity, transferring glycosyl groups
WM43_00840	COG5001	Diguanylate cyclase
WM43_00840	COG2203	Gaf domain
WM43_00840	COG3706	GGDEF domain
WM43_00840	COG4251	negative regulation of phosphorylation
WM43_00845	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WM43_00850	COG0437	4 iron, 4 sulfur cluster binding
WM43_00855	COG5557	Pfam Polysulphide reductase, NrfD
WM43_00860	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WM43_00865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WM43_00870	COG1773	rubredoxin
WM43_00885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WM43_00895	COG3842	ATPase activity
WM43_00900	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WM43_00905	COG0375	protein maturation
WM43_00910	COG0309	Hydrogenase expression formation protein (HypE)
WM43_00920	COG0298	carbon dioxide binding
WM43_00925	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WM43_00950	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WM43_00960	COG3260	NADH ubiquinone oxidoreductase 20
WM43_00965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_00970	COG3261	NADH dehydrogenase
WM43_00970	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
WM43_00975	COG0650	Formate hydrogenlyase subunit 4
WM43_00980	COG0651	ATP synthesis coupled electron transport
WM43_00985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WM43_00990	COG3158	transport of potassium into the cell
WM43_01005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WM43_01010	COG3383	formate dehydrogenase (NAD+) activity
WM43_01015	COG3383	formate dehydrogenase (NAD+) activity
WM43_01035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WM43_01040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_01045	COG3046	protein related to deoxyribodipyrimidine photolyase
WM43_01050	COG3033	Beta-eliminating lyase
WM43_01055	COG0295	cytidine deaminase activity
WM43_01060	COG1346	cytolysis
WM43_01065	COG1380	Effector of murein hydrolase LrgA
WM43_01070	COG3345	alpha-galactosidase
WM43_01080	COG2925	Exonuclease
WM43_01100	COG5433	transposase activity
WM43_01110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WM43_01135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WM43_01140	COG1484	DNA-dependent DNA replication
WM43_01145	COG4584	PFAM Integrase catalytic
WM43_01200	COG0641	radical SAM
WM43_01225	COG2304	oxidoreductase activity
WM43_01230	COG2304	oxidoreductase activity
WM43_01245	COG0714	Associated with various cellular activities
WM43_01250	COG3119	arylsulfatase activity
WM43_01255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WM43_01265	COG1643	Atp-dependent helicase
WM43_01275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WM43_01290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WM43_01295	COG2067	long-chain fatty acid transport protein
WM43_01310	COG1595	DNA-templated transcription, initiation
WM43_01320	COG2304	oxidoreductase activity
WM43_01340	COG0714	Associated with various cellular activities
WM43_01345	COG0183	Belongs to the thiolase family
WM43_01350	COG1250	3-hydroxyacyl-CoA dehydrogenase
WM43_01350	COG1024	Enoyl-CoA hydratase
WM43_01355	COG2719	SpoVR family
WM43_01360	COG2718	Belongs to the UPF0229 family
WM43_01365	COG2766	serine protein kinase
WM43_01370	COG0514	ATP-dependent DNA helicase (RecQ)
WM43_01375	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WM43_01380	COG0814	amino acid
WM43_01385	COG0494	nUDIX hydrolase
WM43_01400	COG2824	Alkylphosphonate utilization operon protein PhnA
WM43_01420	COG0406	alpha-ribazole phosphatase activity
WM43_01425	COG3706	GGDEF domain
WM43_01430	COG2840	Smr protein MutS2
WM43_01435	COG2890	protein-(glutamine-N5) methyltransferase activity
WM43_01440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WM43_01450	COG0513	Belongs to the DEAD box helicase family
WM43_01460	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WM43_01470	COG0814	amino acid
WM43_01475	COG1609	Transcriptional regulator
WM43_01480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_01480	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_01485	COG1105	Belongs to the carbohydrate kinase PfkB family
WM43_01490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_01490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_01490	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WM43_01495	COG1530	ribonuclease E activity
WM43_01510	COG0424	maF-like protein
WM43_01515	COG1399	metal-binding, possibly nucleic acid-binding protein
WM43_01520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WM43_01525	COG0416	fatty acid biosynthetic process
WM43_01530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WM43_01540	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_01545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WM43_01550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM43_01555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WM43_01560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WM43_01565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WM43_01570	COG0470	DNA polymerase III
WM43_01575	COG0084	hydrolase, TatD family'
WM43_01590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WM43_01590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WM43_01595	COG3008	intermembrane lipid transfer
WM43_01600	COG2995	paraquat-inducible protein a
WM43_01610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WM43_01615	COG0372	Belongs to the citrate synthase family
WM43_01660	COG5433	transposase activity
WM43_01665	COG4221	oxidoreductase activity
WM43_01670	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WM43_01675	COG3141	response to X-ray
WM43_01695	COG1067	ATP-dependent peptidase activity
WM43_01700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM43_01720	COG0116	Belongs to the methyltransferase superfamily
WM43_01720	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WM43_01725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WM43_01730	COG0254	rRNA binding
WM43_01745	COG0167	dihydroorotate dehydrogenase activity
WM43_01750	COG2902	Dehydrogenase
WM43_01760	COG0308	aminopeptidase N
WM43_01770	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WM43_01775	COG1956	GAF domain-containing protein
WM43_01785	COG3278	Belongs to the heme-copper respiratory oxidase family
WM43_01800	COG2010	Cytochrome c
WM43_01810	COG2217	Heavy metal translocating P-type atpase
WM43_01825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM43_01830	COG0589	response to stress
WM43_01835	COG0037	tRNA processing
WM43_01855	COG1176	ABC-type spermidine putrescine transport system, permease component I
WM43_01860	COG1177	transmembrane transport
WM43_01865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WM43_01880	COG1869	D-ribose catabolic process
WM43_01885	COG1129	ABC transporter
WM43_01890	COG1172	Belongs to the binding-protein-dependent transport system permease family
WM43_01895	COG1879	ABC-type sugar transport system periplasmic component
WM43_01900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WM43_01905	COG1609	Transcriptional regulator
WM43_01910	COG5001	Diguanylate cyclase
WM43_01910	COG3300	MHYT domain
WM43_01920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WM43_01935	COG0784	Response regulator, receiver
WM43_01935	COG2205	protein histidine kinase activity
WM43_01940	COG0776	regulation of translation
WM43_01945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM43_01945	COG0072	phenylalanine-tRNA ligase activity
WM43_01950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WM43_01955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WM43_01960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WM43_01965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WM43_01970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WM43_01985	COG0366	Alpha amylase catalytic
WM43_01995	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WM43_02005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WM43_02010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WM43_02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM43_02020	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WM43_02025	COG3313	Fe-S protein
WM43_02030	COG2942	2-epimerase
WM43_02035	COG3716	PTS system mannose fructose sorbose family IID component
WM43_02040	COG3715	PTS system
WM43_02045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WM43_02045	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_02060	COG1609	Transcriptional regulator
WM43_02065	COG2140	Oxalate decarboxylase
WM43_02070	COG0306	phosphate transporter
WM43_02075	COG0717	Belongs to the dCTP deaminase family
WM43_02080	COG0572	uridine kinase
WM43_02085	COG0489	protein tyrosine kinase activity
WM43_02090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM43_02090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM43_02100	COG1254	Belongs to the acylphosphatase family
WM43_02110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WM43_02115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WM43_02130	COG0709	Synthesizes selenophosphate from selenide and ATP
WM43_02135	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WM43_02140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WM43_02155	COG0318	PFAM AMP-dependent synthetase and ligase
WM43_02160	COG2267	carboxylic ester hydrolase activity
WM43_02170	COG1214	PFAM Peptidase M22, glycoprotease
WM43_02175	COG1199	ATP-dependent helicase activity
WM43_02185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WM43_02190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WM43_02195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WM43_02200	COG0131	Imidazoleglycerol-phosphate dehydratase
WM43_02200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WM43_02205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WM43_02210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WM43_02215	COG0107	imidazoleglycerol-phosphate synthase activity
WM43_02230	COG3706	GGDEF domain
WM43_02235	COG0318	PFAM AMP-dependent synthetase and ligase
WM43_02240	COG1288	antiporter activity
WM43_02255	COG3134	Outer membrane lipoprotein
WM43_02260	COG2080	2 iron, 2 sulfur cluster binding
WM43_02265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WM43_02270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WM43_02275	COG2252	PERMEase
WM43_02280	COG0402	S-adenosylhomocysteine deaminase activity
WM43_02285	COG2233	PERMEase
WM43_02290	COG2080	2 iron, 2 sulfur cluster binding
WM43_02290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WM43_02295	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WM43_02300	COG0402	S-adenosylhomocysteine deaminase activity
WM43_02305	COG0493	'glutamate synthase
WM43_02305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WM43_02310	COG2068	MobA-Related Protein
WM43_02315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WM43_02320	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WM43_02320	COG3608	succinylglutamate desuccinylase aspartoacylase
WM43_02325	COG0697	spore germination
WM43_02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM43_02350	COG0549	Belongs to the carbamate kinase family
WM43_02360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM43_02365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WM43_02370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WM43_02400	COG0242	peptide deformylase activity
WM43_02410	COG0693	protein deglycase activity
WM43_02425	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WM43_02430	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WM43_02440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WM43_02445	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WM43_02455	COG0205	6-phosphofructokinase activity
WM43_02460	COG1301	dicarboxylic acid transport
WM43_02465	COG3123	guanosine phosphorylase activity
WM43_02470	COG1760	l-serine dehydratase
WM43_02475	COG1760	l-serine dehydratase
WM43_02480	COG3100	YcgL domain-containing protein
WM43_02485	COG0850	regulation of cytokinetic process
WM43_02490	COG2894	cell division
WM43_02495	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WM43_02505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WM43_02545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WM43_02550	COG0697	spore germination
WM43_02555	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WM43_02560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM43_02570	COG0307	riboflavin synthase, alpha
WM43_02585	COG0534	Mate efflux family protein
WM43_02630	COG4681	YaeQ
WM43_02640	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WM43_02645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WM43_02650	COG0586	Pfam SNARE associated Golgi protein
WM43_02660	COG0556	nucleotide-excision repair
WM43_02670	COG0569	domain protein
WM43_02670	COG2985	domain, Protein
WM43_02675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WM43_02680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_02680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WM43_02695	COG3069	C4-dicarboxylate transmembrane transporter activity
WM43_02710	COG1451	nucleotide metabolic process
WM43_02725	COG0417	DNA replication proofreading
WM43_02735	COG2203	Gaf domain
WM43_02735	COG2199	diguanylate cyclase activity
WM43_02750	COG1560	Kdo2-lipid A biosynthetic process
WM43_02755	COG1560	Kdo2-lipid A biosynthetic process
WM43_02770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WM43_02775	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WM43_02780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WM43_02785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WM43_02790	COG2832	Protein of unknown function (DUF454)
WM43_02795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM43_02810	COG1011	Hydrolase
WM43_02815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WM43_02865	COG3593	DNA synthesis involved in DNA repair
WM43_02880	COG0583	DNA-binding transcription factor activity
WM43_02885	COG0730	response to heat
WM43_02895	COG1846	Transcriptional regulator
WM43_02895	COG1940	carbohydrate kinase activity
WM43_02900	COG0840	transmembrane signaling receptor activity
WM43_02905	COG3012	SEC-C Motif Domain Protein
WM43_02910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WM43_02915	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WM43_02920	COG0247	lactate metabolic process
WM43_02935	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WM43_02940	COG0437	4 iron, 4 sulfur cluster binding
WM43_02945	COG3301	Polysulphide reductase, NrfD
WM43_02950	COG1138	Cytochrome C-type biogenesis protein
WM43_02960	COG4235	cytochrome complex assembly
WM43_02960	COG3088	subunit of a heme lyase
WM43_02975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM43_02985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WM43_02995	COG1840	ABC-type Fe3 transport system, periplasmic component
WM43_03000	COG3842	ATPase activity
WM43_03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_03030	COG1115	amino acid carrier protein
WM43_03065	COG1024	Enoyl-CoA hydratase
WM43_03080	COG3162	membrane
WM43_03085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM43_03090	COG0488	(ABC) transporter
WM43_03095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM43_03100	COG0776	regulation of translation
WM43_03105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WM43_03110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WM43_03115	COG0740	serine-type endopeptidase activity
WM43_03120	COG0544	peptidyl-prolyl cis-trans isomerase activity
WM43_03130	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WM43_03135	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM43_03140	COG1136	(ABC) transporter
WM43_03145	COG4591	ABC-type transport system involved in lipoprotein release permease component
WM43_03155	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WM43_03160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WM43_03165	COG4166	transmembrane transport
WM43_03170	COG0697	spore germination
WM43_03180	COG2062	phosphohistidine phosphatase, SixA
WM43_03185	COG1025	Belongs to the peptidase M16 family
WM43_03215	COG5290	Psort location Cytoplasmic, score
WM43_03225	COG0519	Catalyzes the synthesis of GMP from XMP
WM43_03225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM43_03230	COG0517	IMP dehydrogenase activity
WM43_03230	COG0516	GMP reductase activity
WM43_03235	COG3038	cytochrome b561
WM43_03240	COG1570	exodeoxyribonuclease VII activity
WM43_03245	COG2188	Transcriptional regulator
WM43_03250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_03250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_03250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_03255	COG0383	alpha-mannosidase activity
WM43_03260	COG1181	Belongs to the D-alanine--D-alanine ligase family
WM43_03270	COG0386	Belongs to the glutathione peroxidase family
WM43_03275	COG0513	Belongs to the DEAD box helicase family
WM43_03290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WM43_03295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WM43_03300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WM43_03320	COG0598	Magnesium transport protein CorA
WM43_03350	COG3300	MHYT domain
WM43_03350	COG5001	Diguanylate cyclase
WM43_03365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WM43_03375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WM43_03380	COG0563	adenylate kinase activity
WM43_03390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WM43_03395	COG1286	toxin biosynthetic process
WM43_03400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WM43_03405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WM43_03410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WM43_03415	COG0531	amino acid
WM43_03415	COG1674	ftsk spoiiie
WM43_03425	COG0686	Belongs to the AlaDH PNT family
WM43_03430	COG0492	ferredoxin-NADP+ reductase activity
WM43_03435	COG3706	GGDEF domain
WM43_03440	COG3134	Outer membrane lipoprotein
WM43_03445	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WM43_03450	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WM43_03455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WM43_03460	COG0542	response to heat
WM43_03465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WM43_03470	COG1278	Cold shock
WM43_03475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WM43_03525	COG5433	transposase activity
WM43_03530	COG5433	transposase activity
WM43_03545	COG5433	transposase activity
WM43_03555	COG5433	transposase activity
WM43_03560	COG3284	Transcriptional regulator
WM43_03575	COG1461	Dihydroxyacetone kinase
WM43_03580	COG2376	Dihydroxyacetone kinase
WM43_03585	COG2252	PERMEase
WM43_03635	COG1462	curli production assembly transport component CsgG
WM43_03650	COG2197	response regulator
WM43_03670	COG3039	Transposase
WM43_03745	COG3550	peptidyl-serine autophosphorylation
WM43_03760	COG0745	RESPONSE REGULATOR receiver
WM43_03765	COG2205	protein histidine kinase activity
WM43_03775	COG0392	lysyltransferase activity
WM43_03775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WM43_03800	COG3318	Belongs to the UPF0149 family
WM43_03800	COG3012	SEC-C Motif Domain Protein
WM43_03805	COG0714	Associated with various cellular activities
WM43_03815	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WM43_03830	COG3039	Transposase
WM43_03855	COG3706	GGDEF domain
WM43_03895	COG0659	secondary active sulfate transmembrane transporter activity
WM43_03910	COG0582	viral genome integration into host DNA
WM43_03940	COG5433	transposase activity
WM43_04010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WM43_04035	COG1104	cysteine desulfurase activity
WM43_04060	COG0672	)-iron permease
WM43_04080	COG2814	Major facilitator Superfamily
WM43_04095	COG1136	(ABC) transporter
WM43_04120	COG0596	Alpha beta hydrolase
WM43_04140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WM43_04145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WM43_04145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WM43_04150	COG0527	aspartate kinase activity
WM43_04160	COG1368	sulfuric ester hydrolase activity
WM43_04165	COG1619	proteins homologs of microcin C7 resistance protein MccF
WM43_04170	COG4667	esterase of the alpha-beta hydrolase superfamily
WM43_04185	COG2221	Nitrite and sulphite reductase 4Fe-4S
WM43_04190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WM43_04190	COG1648	precorrin-2 dehydrogenase activity
WM43_04200	COG0393	Putative heavy-metal-binding
WM43_04205	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WM43_04210	COG0285	dihydrofolate synthase activity
WM43_04215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WM43_04220	COG0101	tRNA pseudouridine synthase activity
WM43_04230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WM43_04240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WM43_04245	COG0671	phosphoesterase, PA-phosphatase related
WM43_04250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM43_04255	COG2056	Na+-H+ antiporter family
WM43_04260	COG5001	Diguanylate cyclase
WM43_04260	COG3300	MHYT domain
WM43_04275	COG2050	protein possibly involved in aromatic compounds catabolism
WM43_04285	COG0277	FAD linked oxidase domain protein
WM43_04285	COG0247	lactate metabolic process
WM43_04295	COG1253	flavin adenine dinucleotide binding
WM43_04300	COG1902	pentaerythritol trinitrate reductase activity
WM43_04310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WM43_04315	COG0647	UMP catabolic process
WM43_04320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WM43_04320	COG4651	solute:proton antiporter activity
WM43_04330	COG0367	asparagine synthase
WM43_04360	COG0322	excinuclease ABC activity
WM43_04365	COG2197	response regulator
WM43_04370	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WM43_04375	COG2835	tetraacyldisaccharide 4'-kinase activity
WM43_04380	COG1663	tetraacyldisaccharide 4'-kinase activity
WM43_04390	COG2333	competence protein COMEC
WM43_04390	COG0658	competence protein
WM43_04405	COG1448	Aminotransferase
WM43_04415	COG0583	DNA-binding transcription factor activity
WM43_04420	COG3085	chromosome segregation
WM43_04425	COG4574	serine-type endopeptidase inhibitor activity
WM43_04430	COG0584	glycerophosphoryl diester phosphodiesterase
WM43_04440	COG1349	DNA-binding transcription factor activity
WM43_04445	COG2271	Major facilitator Superfamily
WM43_04450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WM43_04455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WM43_04470	COG0583	DNA-binding transcription factor activity
WM43_04490	COG0656	L-ascorbic acid biosynthetic process
WM43_04500	COG2814	Major facilitator Superfamily
WM43_04505	COG2249	NAD(P)H dehydrogenase (quinone) activity
WM43_04520	COG3220	belongs to the UPF0276 family
WM43_04540	COG1294	oxidase, subunit
WM43_04550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WM43_04560	COG2979	Protein of unknown function (DUF533)
WM43_04565	COG1607	acyl-coa hydrolase
WM43_04575	COG2807	transmembrane transport
WM43_04580	COG1187	pseudouridine synthase activity
WM43_04590	COG0346	lactoylglutathione lyase activity
WM43_04625	COG4657	Part of a membrane complex involved in electron transport
WM43_04630	COG2878	Part of a membrane complex involved in electron transport
WM43_04640	COG4658	electron transport chain
WM43_04645	COG4659	FMN binding
WM43_04655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WM43_04660	COG0346	lactoylglutathione lyase activity
WM43_04690	COG2801	Transposase and inactivated derivatives
WM43_04700	COG5433	transposase activity
WM43_04710	COG1199	ATP-dependent helicase activity
WM43_04720	COG0123	including yeast histone deacetylase and acetoin utilization protein
WM43_04725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WM43_04730	COG1785	Belongs to the alkaline phosphatase family
WM43_04750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM43_04755	COG2197	response regulator
WM43_04765	COG2271	Major facilitator Superfamily
WM43_04770	COG3706	GGDEF domain
WM43_04775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_04780	COG0765	amino acid transport
WM43_04785	COG1126	abc transporter atp-binding protein
WM43_04800	COG0531	amino acid
WM43_04815	COG1253	flavin adenine dinucleotide binding
WM43_04820	COG0704	Plays a role in the regulation of phosphate uptake
WM43_04830	COG0581	inorganic phosphate transmembrane transporter activity
WM43_04835	COG0573	inorganic phosphate transmembrane transporter activity
WM43_04840	COG0590	tRNA wobble adenosine to inosine editing
WM43_04850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WM43_04870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WM43_04875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WM43_04880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WM43_04885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WM43_04890	COG2204	response regulator
WM43_04895	COG3852	Histidine kinase
WM43_04900	COG2204	response regulator
WM43_04910	COG2716	regulation of RNA biosynthetic process
WM43_04915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WM43_04920	COG0248	Ppx GppA phosphatase
WM43_04925	COG2239	Acts as a magnesium transporter
WM43_04930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WM43_04945	COG1706	bacterial-type flagellum-dependent cell motility
WM43_04950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WM43_04955	COG4786	Flagellar basal body rod
WM43_04960	COG4787	bacterial-type flagellum-dependent cell motility
WM43_04975	COG1558	bacterial-type flagellum-dependent cell motility
WM43_04980	COG1815	bacterial-type flagellum-dependent cell motility
WM43_04985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WM43_04990	COG0835	chemotaxis
WM43_04990	COG0784	Response regulator, receiver
WM43_04995	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WM43_05010	COG0622	Phosphoesterase
WM43_05015	COG4166	transmembrane transport
WM43_05025	COG1187	pseudouridine synthase activity
WM43_05030	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WM43_05040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WM43_05045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WM43_05055	COG1349	DNA-binding transcription factor activity
WM43_05060	COG4166	transmembrane transport
WM43_05085	COG1278	Cold shock
WM43_05110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WM43_05110	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
WM43_05115	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_05120	COG3433	isochorismatase activity
WM43_05120	COG1535	isochorismatase
WM43_05125	COG1021	2,3-dihydroxybenzoate-AMP ligase
WM43_05130	COG1169	isochorismate synthase
WM43_05135	COG4771	TonB-dependent receptor
WM43_05140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WM43_05145	COG1609	Transcriptional regulator
WM43_05150	COG0741	lytic transglycosylase activity
WM43_05160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WM43_05180	COG2911	Protein conserved in bacteria
WM43_05185	COG0729	surface antigen
WM43_05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM43_05210	COG2801	Transposase and inactivated derivatives
WM43_05215	COG2963	transposase activity
WM43_05225	COG1943	Transposase
WM43_05230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WM43_05240	COG4134	Bacterial extracellular solute-binding protein
WM43_05250	COG4136	ATPase activity
WM43_05255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WM43_05260	COG2951	lytic endotransglycosylase activity
WM43_05265	COG0033	Phosphoglucomutase
WM43_05270	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WM43_05275	COG0596	Alpha beta hydrolase
WM43_05290	COG0716	FMN binding
WM43_05300	COG0735	belongs to the Fur family
WM43_05305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM43_05315	COG1263	PTS System
WM43_05315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WM43_05315	COG2190	(PTS) system
WM43_05320	COG0363	glucosamine-6-phosphate deaminase activity
WM43_05325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WM43_05330	COG1940	carbohydrate kinase activity
WM43_05330	COG1846	Transcriptional regulator
WM43_05340	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WM43_05340	COG2199	diguanylate cyclase activity
WM43_05345	COG3275	phosphorelay sensor kinase activity
WM43_05350	COG3279	Response regulator of the LytR AlgR family
WM43_05355	COG1966	Carbon starvation protein
WM43_05365	COG1566	PFAM secretion protein HlyD family protein
WM43_05370	COG1061	Type III restriction enzyme res subunit
WM43_05375	COG2027	D-alanyl-D-alanine carboxypeptidase
WM43_05380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WM43_05385	COG3021	interspecies interaction between organisms
WM43_05395	COG1607	acyl-coa hydrolase
WM43_05400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM43_05410	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WM43_05410	COG1013	pyruvate-flavodoxin oxidoreductase activity
WM43_05410	COG0674	pyruvate-flavodoxin oxidoreductase activity
WM43_05410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WM43_05425	COG0633	Ferredoxin
WM43_05425	COG3217	Mosc domain protein beta barrel domain protein
WM43_05425	COG0633	Ferredoxin
WM43_05425	COG3217	Mosc domain protein beta barrel domain protein
WM43_05435	COG0501	Belongs to the peptidase M48B family
WM43_05440	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WM43_05445	COG1073	alpha beta
WM43_05445	COG2226	methyltransferase
WM43_05450	COG0156	8-amino-7-oxononanoate synthase activity
WM43_05455	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WM43_05460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WM43_05475	COG0017	Asparaginyl-tRNA synthetase
WM43_05485	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WM43_05495	COG1473	amidohydrolase
WM43_05500	COG3069	C4-dicarboxylate transmembrane transporter activity
WM43_05510	COG1393	Belongs to the ArsC family
WM43_05515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WM43_05520	COG1876	peptidase activity
WM43_05525	COG3263	regulation of cellular component size
WM43_05540	COG1280	lysine exporter protein (LysE YggA)
WM43_05570	COG0564	pseudouridine synthase activity
WM43_05580	COG1454	alcohol dehydrogenase
WM43_05620	COG2894	cell division
WM43_05630	COG4964	Belongs to the GSP D family
WM43_05660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM43_05665	COG0702	epimerase
WM43_05675	COG0095	Lipoate-protein ligase
WM43_05685	COG0577	efflux transmembrane transporter activity
WM43_05685	COG1136	(ABC) transporter
WM43_05690	COG0577	efflux transmembrane transporter activity
WM43_05690	COG1136	(ABC) transporter
WM43_05695	COG1136	(ABC) transporter
WM43_05695	COG0577	efflux transmembrane transporter activity
WM43_05700	COG1566	PFAM secretion protein HlyD family protein
WM43_05735	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM43_05745	COG1285	pathogenesis
WM43_05775	COG0484	heat shock protein binding
WM43_05780	COG0443	Heat shock 70 kDa protein
WM43_05785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WM43_05790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WM43_05795	COG0497	DNA recombination
WM43_05800	COG1227	inorganic diphosphatase activity
WM43_05805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_05810	COG1136	(ABC) transporter
WM43_05810	COG0577	efflux transmembrane transporter activity
WM43_05815	COG1538	Outer membrane efflux protein
WM43_05830	COG2963	transposase activity
WM43_05835	COG2801	Transposase and inactivated derivatives
WM43_05845	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM43_05870	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WM43_05875	COG3039	Transposase
WM43_05910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WM43_05920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WM43_05940	COG1086	Polysaccharide biosynthesis protein
WM43_05955	COG1091	dTDP-4-dehydrorhamnose reductase activity
WM43_05965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM43_05970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_05975	COG1309	transcriptional regulator
WM43_05990	COG1342	Belongs to the UPF0251 family
WM43_06010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM43_06015	COG3039	Transposase
WM43_06020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WM43_06025	COG0083	homoserine kinase activity
WM43_06035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WM43_06040	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WM43_06045	COG1946	Acyl-CoA thioesterase
WM43_06055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WM43_06065	COG0009	L-threonylcarbamoyladenylate synthase
WM43_06075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WM43_06080	COG0512	Glutamine amidotransferase of anthranilate synthase
WM43_06080	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WM43_06085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WM43_06090	COG0134	indole-3-glycerol-phosphate synthase activity
WM43_06090	COG0135	phosphoribosylanthranilate isomerase activity
WM43_06095	COG0133	tryptophan synthase activity
WM43_06100	COG0159	tryptophan synthase activity
WM43_06105	COG2801	Transposase and inactivated derivatives
WM43_06115	COG1988	membrane-bound metal-dependent
WM43_06135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM43_06145	COG0798	PFAM Bile acid sodium symporter
WM43_06175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WM43_06185	COG0745	RESPONSE REGULATOR receiver
WM43_06200	COG4988	ABC transporter
WM43_06205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WM43_06225	COG1720	tRNA m6t6A37 methyltransferase activity
WM43_06230	COG3038	cytochrome b561
WM43_06240	COG0745	RESPONSE REGULATOR receiver
WM43_06265	COG5433	transposase activity
WM43_06290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_06295	COG1917	Cupin 2, conserved barrel domain protein
WM43_06295	COG1396	sequence-specific DNA binding
WM43_06310	COG0531	amino acid
WM43_06320	COG0531	amino acid
WM43_06330	COG1283	sodium-dependent phosphate transmembrane transporter activity
WM43_06340	COG0405	Gamma-glutamyltransferase
WM43_06345	COG2974	May be involved in recombination
WM43_06355	COG0420	3'-5' exonuclease activity
WM43_06360	COG0419	ATPase involved in DNA repair
WM43_06365	COG3384	dioxygenase
WM43_06375	COG0469	pyruvate kinase activity
WM43_06380	COG1196	nuclear chromosome segregation
WM43_06380	COG3264	Mechanosensitive ion channel
WM43_06390	COG3590	peptidase
WM43_06395	COG3706	GGDEF domain
WM43_06400	COG2190	(PTS) system
WM43_06410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_06415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WM43_06420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM43_06435	COG2770	Histidine kinase
WM43_06435	COG3437	response regulator, receiver
WM43_06440	COG3267	Type II secretory pathway component ExeA
WM43_06440	COG3409	Peptidoglycan-binding domain 1 protein
WM43_06450	COG3031	protein transport across the cell outer membrane
WM43_06460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM43_06465	COG1459	type II secretion system
WM43_06470	COG2165	general secretion pathway protein
WM43_06480	COG2165	general secretion pathway protein
WM43_06485	COG4795	General secretion pathway protein
WM43_06490	COG3156	type II secretion system protein K
WM43_06500	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WM43_06510	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
WM43_06535	COG0561	phosphatase activity
WM43_06540	COG3623	hexulose-6-phosphate isomerase
WM43_06555	COG0670	Belongs to the BI1 family
WM43_06560	COG1289	transmembrane transporter activity
WM43_06565	COG2920	part of a sulfur-relay system
WM43_06570	COG0673	inositol 2-dehydrogenase activity
WM43_06595	COG1032	radical SAM domain protein
WM43_06605	COG1566	PFAM secretion protein HlyD family protein
WM43_06610	COG3706	GGDEF domain
WM43_06615	COG1752	Esterase of the alpha-beta hydrolase superfamily
WM43_06620	COG0531	amino acid
WM43_06655	COG0281	malic enzyme
WM43_06665	COG0534	Mate efflux family protein
WM43_06675	COG3706	GGDEF domain
WM43_06680	COG2233	PERMEase
WM43_06685	COG0095	Lipoate-protein ligase
WM43_06690	COG1115	amino acid carrier protein
WM43_06695	COG0019	diaminopimelate decarboxylase activity
WM43_06705	COG0678	peroxiredoxin activity
WM43_06730	COG0545	Peptidyl-prolyl cis-trans isomerase
WM43_06735	COG3142	Participates in the control of copper homeostasis
WM43_06750	COG4783	chaperone-mediated protein folding
WM43_06760	COG5002	protein histidine kinase activity
WM43_06765	COG0745	RESPONSE REGULATOR receiver
WM43_06770	COG0346	lactoylglutathione lyase activity
WM43_06775	COG3284	Transcriptional regulator
WM43_06780	COG1012	belongs to the aldehyde dehydrogenase family
WM43_06790	COG0697	spore germination
WM43_06800	COG3290	protein histidine kinase activity
WM43_06805	COG0281	malic enzyme
WM43_06815	COG1846	Transcriptional regulator
WM43_06820	COG1566	PFAM secretion protein HlyD family protein
WM43_06845	COG0602	queuosine metabolic process
WM43_06850	COG1328	CTP reductase activity
WM43_06860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WM43_06865	COG3115	cell septum assembly
WM43_06870	COG1196	nuclear chromosome segregation
WM43_06880	COG2860	membrane
WM43_06890	COG3108	Peptidase M15
WM43_06895	COG2989	Protein conserved in bacteria
WM43_06910	COG0463	Glycosyl transferase, family 2
WM43_06925	COG0366	Alpha amylase catalytic
WM43_06960	COG2203	Gaf domain
WM43_06960	COG2199	diguanylate cyclase activity
WM43_06970	COG3590	peptidase
WM43_06985	COG1982	Orn Lys Arg decarboxylase major
WM43_06990	COG0531	amino acid
WM43_06995	COG3710	Transcriptional regulator
WM43_07000	COG0531	amino acid
WM43_07010	COG5433	transposase activity
WM43_07030	COG0814	amino acid
WM43_07060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WM43_07065	COG0739	heme binding
WM43_07070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WM43_07095	COG0251	oxidation-reduction process
WM43_07110	COG0583	DNA-binding transcription factor activity
WM43_07130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WM43_07140	COG3091	SprT-like family
WM43_07150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WM43_07155	COG0189	ligase activity
WM43_07160	COG1678	Uncharacterized ACR, COG1678
WM43_07165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WM43_07170	COG3104	oligopeptide transport
WM43_07175	COG0583	DNA-binding transcription factor activity
WM43_07185	COG0714	Associated with various cellular activities
WM43_07200	COG1115	amino acid carrier protein
WM43_07205	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WM43_07215	COG0825	malonyl-CoA metabolic process
WM43_07225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WM43_07230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM43_07235	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM43_07240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WM43_07245	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM43_07255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM43_07260	COG0750	zinc metalloprotease
WM43_07265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WM43_07270	COG0575	Belongs to the CDS family
WM43_07280	COG0233	cytoplasmic translational termination
WM43_07285	COG0528	UMP kinase activity
WM43_07290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WM43_07295	COG0052	Belongs to the universal ribosomal protein uS2 family
WM43_07300	COG0024	Methionine aminopeptidase
WM43_07310	COG2171	N-acyltransferase activity
WM43_07320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WM43_07320	COG1263	PTS System
WM43_07340	COG0564	pseudouridine synthase activity
WM43_07345	COG3098	single-species biofilm formation
WM43_07370	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WM43_07390	COG3328	transposase activity
WM43_07400	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WM43_07410	COG2963	transposase activity
WM43_07415	COG2801	Transposase and inactivated derivatives
WM43_07460	COG0328	RNA-DNA hybrid ribonuclease activity
WM43_07485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WM43_07485	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WM43_07495	COG3706	GGDEF domain
WM43_07500	COG1611	Belongs to the LOG family
WM43_07505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WM43_07510	COG0473	3-isopropylmalate dehydrogenase activity
WM43_07520	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WM43_07525	COG2363	Small membrane protein
WM43_07535	COG0583	DNA-binding transcription factor activity
WM43_07540	COG0840	transmembrane signaling receptor activity
WM43_07545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WM43_07560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WM43_07565	COG1666	GTP binding
WM43_07575	COG2211	Major facilitator Superfamily
WM43_07580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM43_07590	COG2813	Specifically methylates the guanine in position
WM43_07595	COG0271	Belongs to the BolA IbaG family
WM43_07600	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WM43_07605	COG1805	sodium ion transport
WM43_07615	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WM43_07620	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WM43_07625	COG2871	sodium ion transport
WM43_07630	COG1477	protein flavinylation
WM43_07660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WM43_07675	COG0300	oxidoreductase activity
WM43_07685	COG0415	Belongs to the DNA photolyase family
WM43_07690	COG0789	Transcriptional regulator
WM43_07695	COG3272	Protein of unknown function (DUF1722)
WM43_07725	COG0077	Prephenate dehydratase
WM43_07725	COG1605	Chorismate mutase
WM43_07755	COG5377	YqaJ viral recombinase family
WM43_07800	COG2003	Belongs to the UPF0758 family
WM43_07815	COG4735	regulation of single-species biofilm formation
WM43_07835	COG5433	transposase activity
WM43_07855	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WM43_07860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WM43_07875	COG5433	transposase activity
WM43_07895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WM43_07940	COG0300	oxidoreductase activity
WM43_07965	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WM43_08005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WM43_08010	COG0826	peptidase U32
WM43_08015	COG1280	lysine exporter protein (LysE YggA)
WM43_08045	COG0643	Histidine kinase
WM43_08045	COG2198	Histidine kinase
WM43_08055	COG0835	chemotaxis
WM43_08060	COG0840	transmembrane signaling receptor activity
WM43_08070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WM43_08075	COG2201	protein-glutamate methylesterase activity
WM43_08080	COG1185	polyribonucleotide nucleotidyltransferase activity
WM43_08085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WM43_08090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WM43_08095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WM43_08100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WM43_08105	COG0195	Participates in both transcription termination and antitermination
WM43_08110	COG0779	Required for maturation of 30S ribosomal subunits
WM43_08125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WM43_08130	COG0149	triose-phosphate isomerase activity
WM43_08135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM43_08140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WM43_08145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM43_08150	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WM43_08155	COG1534	Rna-binding protein
WM43_08165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM43_08170	COG1360	Flagellar Motor Protein
WM43_08175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WM43_08180	COG1722	exodeoxyribonuclease VII activity
WM43_08185	COG0142	geranyltranstransferase activity
WM43_08190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WM43_08195	COG0737	Belongs to the 5'-nucleotidase family
WM43_08215	COG2204	response regulator
WM43_08220	COG0545	Peptidyl-prolyl cis-trans isomerase
WM43_08230	COG2900	Belongs to the SlyX family
WM43_08255	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WM43_08260	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WM43_08265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WM43_08270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WM43_08285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM43_08285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WM43_08290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WM43_08300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WM43_08310	COG2198	Histidine kinase
WM43_08310	COG2205	protein histidine kinase activity
WM43_08310	COG0784	Response regulator, receiver
WM43_08315	COG1879	ABC-type sugar transport system periplasmic component
WM43_08325	COG0745	RESPONSE REGULATOR receiver
WM43_08330	COG3005	denitrification pathway
WM43_08340	COG3381	protein complex oligomerization
WM43_08360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM43_08365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WM43_08370	COG0511	ligase activity, forming carbon-carbon bonds
WM43_08375	COG0439	Biotin carboxylase
WM43_08380	COG3924	membrane
WM43_08385	COG4145	pantothenate transmembrane transporter activity
WM43_08390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WM43_08390	COG2190	(PTS) system
WM43_08390	COG1263	PTS System
WM43_08395	COG0583	DNA-binding transcription factor activity
WM43_08400	COG0604	alcohol dehydrogenase
WM43_08405	COG2264	protein methyltransferase activity
WM43_08415	COG0778	Nitroreductase
WM43_08420	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM43_08420	COG1902	pentaerythritol trinitrate reductase activity
WM43_08425	COG0616	signal peptide processing
WM43_08440	COG2801	Transposase and inactivated derivatives
WM43_08455	COG0848	biopolymer transport protein
WM43_08460	COG0811	peptide transport
WM43_08465	COG0811	peptide transport
WM43_08475	COG4206	TonB-dependent receptor
WM43_08480	COG4174	ABC transporter (Permease)
WM43_08485	COG4239	(ABC) transporter, permease
WM43_08495	COG0444	Belongs to the ABC transporter superfamily
WM43_08500	COG4608	Belongs to the ABC transporter superfamily
WM43_08520	COG3416	Protein conserved in bacteria
WM43_08530	COG0741	lytic transglycosylase activity
WM43_08545	COG0488	(ABC) transporter
WM43_08555	COG2252	PERMEase
WM43_08560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM43_08565	COG0840	transmembrane signaling receptor activity
WM43_08575	COG1278	Cold shock
WM43_08615	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WM43_08625	COG0688	phosphatidylethanolamine metabolic process
WM43_08630	COG4628	conserved protein (DUF2132)
WM43_08645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WM43_08665	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WM43_08670	COG2195	Cleaves the N-terminal amino acid of tripeptides
WM43_08675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WM43_08680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WM43_08685	COG3178	'Phosphotransferase
WM43_08690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WM43_08695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WM43_08700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WM43_08705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WM43_08715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WM43_08730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WM43_08745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WM43_08750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WM43_08755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WM43_08760	COG0142	geranyltranstransferase activity
WM43_08765	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WM43_08770	COG0330	HflC and HflK could
WM43_08775	COG0330	HflC and HflK could
WM43_08780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WM43_08785	COG1923	regulation of RNA biosynthetic process
WM43_08790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WM43_08795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WM43_08800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WM43_08810	COG0802	atpase or kinase
WM43_08815	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WM43_08815	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WM43_08835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WM43_08840	COG2011	ABC-type metal ion transport system permease component
WM43_08845	COG1464	Belongs to the NlpA lipoprotein family
WM43_08880	COG5002	protein histidine kinase activity
WM43_08880	COG2198	Histidine kinase
WM43_08880	COG0784	Response regulator, receiver
WM43_08915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WM43_08920	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WM43_08925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WM43_08930	COG2716	regulation of RNA biosynthetic process
WM43_08935	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WM43_08940	COG3013	Belongs to the UPF0304 family
WM43_08945	COG3092	negative regulation of chromosome organization
WM43_08950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WM43_08955	COG0280	phosphate acetyltransferase
WM43_08955	COG0857	belongs to the CobB CobQ family
WM43_08960	COG1555	photosystem II stabilization
WM43_08965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WM43_08970	COG3104	oligopeptide transport
WM43_08975	COG0745	RESPONSE REGULATOR receiver
WM43_09005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_09020	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WM43_09055	COG0440	acetolactate synthase activity
WM43_09060	COG0028	Belongs to the TPP enzyme family
WM43_09080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WM43_09085	COG0473	3-isopropylmalate dehydrogenase activity
WM43_09090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WM43_09095	COG0066	3-isopropylmalate dehydratase activity
WM43_09110	COG4143	(ABC) transporter
WM43_09115	COG1178	ABC-type Fe3 transport system permease component
WM43_09120	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WM43_09125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WM43_09135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WM43_09175	COG0459	protein refolding
WM43_09180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WM43_09195	COG3030	protein affecting phage T7 exclusion by the F plasmid
WM43_09200	COG1027	Aspartate ammonia-lyase
WM43_09205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WM43_09210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WM43_09215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WM43_09220	COG1610	YqeY-like protein
WM43_09230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WM43_09270	COG0582	viral genome integration into host DNA
WM43_09285	COG0151	Belongs to the GarS family
WM43_09290	COG0138	bifunctional purine biosynthesis protein purh
WM43_09300	COG3036	rescue of stalled ribosome
WM43_09305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WM43_09310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WM43_09320	COG0673	inositol 2-dehydrogenase activity
WM43_09330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WM43_09335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WM43_09345	COG0583	DNA-binding transcription factor activity
WM43_09350	COG0477	Major facilitator Superfamily
WM43_09365	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_09370	COG0745	RESPONSE REGULATOR receiver
WM43_09370	COG3706	GGDEF domain
WM43_09375	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WM43_09390	COG0456	acetyltransferase
WM43_09400	COG1022	Amp-dependent synthetase and ligase
WM43_09405	COG2918	glutathione biosynthetic process
WM43_09410	COG0612	Peptidase, M16
WM43_09415	COG1238	metal cluster binding
WM43_09420	COG1064	alcohol dehydrogenase
WM43_09440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM43_09445	COG0359	binds to the 23S rRNA
WM43_09450	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WM43_09455	COG0360	Binds together with S18 to 16S ribosomal RNA
WM43_09460	COG1914	H( )-stimulated, divalent metal cation uptake system
WM43_09465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WM43_09475	COG0776	regulation of translation
WM43_09490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WM43_09505	COG0560	Phosphoserine phosphatase
WM43_09515	COG0813	purine-nucleoside phosphorylase activity
WM43_09520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WM43_09525	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WM43_09530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WM43_09540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM43_09545	COG0084	hydrolase, TatD family'
WM43_09555	COG1854	S-ribosylhomocysteine lyase activity
WM43_09570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM43_09570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WM43_09610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WM43_09615	COG1047	Peptidyl-prolyl cis-trans
WM43_09620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WM43_09625	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WM43_09630	COG0196	riboflavin kinase activity
WM43_09635	COG0728	peptidoglycan biosynthetic process
WM43_09640	COG0268	Binds directly to 16S ribosomal RNA
WM43_09645	COG0640	Transcriptional regulator
WM43_09650	COG0583	DNA-binding transcription factor activity
WM43_09660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WM43_09665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WM43_09670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WM43_09675	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
WM43_09680	COG1051	belongs to the nudix hydrolase family
WM43_09685	COG3066	DNA modification
WM43_09695	COG0335	large ribosomal subunit rRNA binding
WM43_09700	COG0336	Belongs to the RNA methyltransferase TrmD family
WM43_09705	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WM43_09710	COG0228	four-way junction DNA binding
WM43_09715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WM43_09720	COG4137	Cytochrome C assembly protein
WM43_09725	COG4536	flavin adenine dinucleotide binding
WM43_09735	COG1017	nitric oxide dioxygenase activity
WM43_09735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM43_09740	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WM43_09745	COG0039	L-malate dehydrogenase activity
WM43_09750	COG4160	amino acid transport
WM43_09755	COG4215	(ABC) transporter
WM43_09760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_09765	COG1126	abc transporter atp-binding protein
WM43_09770	COG1438	arginine binding
WM43_09775	COG2837	iron assimilation
WM43_09780	COG3842	ATPase activity
WM43_09790	COG1840	ABC-type Fe3 transport system, periplasmic component
WM43_09795	COG0347	Belongs to the P(II) protein family
WM43_09815	COG3022	response to hydroperoxide
WM43_09830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WM43_09835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WM43_09840	COG0762	integral membrane protein
WM43_09845	COG1872	DUF167
WM43_09855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM43_09860	COG0583	DNA-binding transcription factor activity
WM43_09875	COG1929	Belongs to the glycerate kinase type-1 family
WM43_09880	COG2610	gluconate transmembrane transporter activity
WM43_09885	COG3835	regulator
WM43_09890	COG3112	Uncharacterised protein family (UPF0231)
WM43_09910	COG3568	Endonuclease Exonuclease Phosphatase
WM43_09920	COG0513	Belongs to the DEAD box helicase family
WM43_09960	COG1448	Aminotransferase
WM43_09975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WM43_09980	COG1328	CTP reductase activity
WM43_10005	COG0633	Ferredoxin
WM43_10005	COG0543	2 iron, 2 sulfur cluster binding
WM43_10020	COG0840	transmembrane signaling receptor activity
WM43_10025	COG3397	chitin binding
WM43_10030	COG0583	DNA-binding transcription factor activity
WM43_10035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WM43_10040	COG4208	sulfate ABC transporter
WM43_10045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WM43_10055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WM43_10060	COG3174	membrane
WM43_10065	COG0110	maltose O-acetyltransferase activity
WM43_10080	COG1011	Hydrolase
WM43_10085	COG0494	nUDIX hydrolase
WM43_10090	COG1218	3'(2'),5'-bisphosphate nucleotidase
WM43_10095	COG0814	amino acid
WM43_10100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM43_10115	COG0626	cystathionine gamma-synthase activity
WM43_10120	COG0527	aspartate kinase activity
WM43_10120	COG0460	homoserine dehydrogenase
WM43_10125	COG0306	phosphate transporter
WM43_10130	COG1392	Phosphate transport regulator
WM43_10140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WM43_10145	COG2813	Specifically methylates the guanine in position
WM43_10150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WM43_10155	COG0297	glycogen (starch) synthase activity
WM43_10195	COG1757	Na H antiporter
WM43_10200	COG0316	Belongs to the HesB IscA family
WM43_10210	COG0038	chloride channel
WM43_10215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WM43_10230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WM43_10230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WM43_10260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WM43_10265	COG0564	pseudouridine synthase activity
WM43_10275	COG0110	maltose O-acetyltransferase activity
WM43_10280	COG0366	Alpha amylase catalytic
WM43_10285	COG1263	PTS System
WM43_10285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WM43_10305	COG0252	asparaginase activity
WM43_10310	COG1253	flavin adenine dinucleotide binding
WM43_10315	COG0586	Pfam SNARE associated Golgi protein
WM43_10320	COG1686	Belongs to the peptidase S11 family
WM43_10355	COG0527	aspartate kinase activity
WM43_10360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WM43_10370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WM43_10375	COG1546	Belongs to the CinA family
WM43_10380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WM43_10385	COG4667	esterase of the alpha-beta hydrolase superfamily
WM43_10395	COG1346	cytolysis
WM43_10400	COG1380	Effector of murein hydrolase LrgA
WM43_10405	COG0583	DNA-binding transcription factor activity
WM43_10415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WM43_10435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WM43_10440	COG2022	thiamine diphosphate biosynthetic process
WM43_10450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WM43_10455	COG0352	thiamine-phosphate diphosphorylase activity
WM43_10460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WM43_10480	COG0745	RESPONSE REGULATOR receiver
WM43_10490	COG0189	ligase activity
WM43_10530	COG0477	Major facilitator Superfamily
WM43_10545	COG0312	modulator of DNA gyrase
WM43_10550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WM43_10565	COG3164	Protein of unknown function
WM43_10570	COG1530	ribonuclease E activity
WM43_10575	COG0424	maF-like protein
WM43_10580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WM43_10585	COG1792	Involved in formation and maintenance of cell shape
WM43_10590	COG1077	Cell shape determining protein MreB Mrl
WM43_10615	COG4968	Prepilin-type N-terminal cleavage methylation domain
WM43_10635	COG1459	type II secretion system
WM43_10640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM43_10685	COG2199	diguanylate cyclase activity
WM43_10685	COG2200	EAL domain
WM43_10705	COG0387	Pfam Sodium calcium exchanger
WM43_10710	COG2986	histidine ammonia-lyase
WM43_10715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WM43_10720	COG0010	Belongs to the arginase family
WM43_10725	COG1228	amidohydrolase
WM43_10730	COG2188	Transcriptional regulator
WM43_10735	COG0288	reversible hydration of carbon dioxide
WM43_10745	COG2177	Part of the ABC transporter FtsEX involved in
WM43_10750	COG2884	Cell division ATP-binding protein ftsE
WM43_10755	COG0552	protein localization to endoplasmic reticulum
WM43_10760	COG0742	ribosomal rna small subunit methyltransferase
WM43_10785	COG2249	NAD(P)H dehydrogenase (quinone) activity
WM43_10790	COG0583	DNA-binding transcription factor activity
WM43_10795	COG4221	oxidoreductase activity
WM43_10810	COG1770	oligopeptidase
WM43_10825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WM43_10830	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM43_10840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM43_10850	COG2095	MarC family integral membrane protein
WM43_10860	COG1301	dicarboxylic acid transport
WM43_10885	COG3714	YhhN family
WM43_10930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WM43_10935	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM43_10940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WM43_10945	COG0049	tRNA binding
WM43_10950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WM43_10955	COG2168	tRNA wobble position uridine thiolation
WM43_10960	COG2923	Belongs to the DsrF TusC family
WM43_10965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WM43_10975	COG2964	Protein conserved in bacteria
WM43_10980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WM43_10985	COG0085	RNA polymerase activity
WM43_10990	COG0222	ribosome binding
WM43_10995	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WM43_11000	COG0081	regulation of translation
WM43_11005	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WM43_11010	COG0250	Participates in transcription elongation, termination and antitermination
WM43_11015	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WM43_11025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WM43_11050	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WM43_11055	COG0569	domain protein
WM43_11060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WM43_11090	COG4191	Histidine kinase
WM43_11090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_11095	COG3005	denitrification pathway
WM43_11100	COG0243	molybdopterin cofactor binding
WM43_11110	COG2205	protein histidine kinase activity
WM43_11115	COG0745	RESPONSE REGULATOR receiver
WM43_11145	COG2204	response regulator
WM43_11155	COG2205	protein histidine kinase activity
WM43_11165	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_11170	COG0517	IMP dehydrogenase activity
WM43_11170	COG0516	GMP reductase activity
WM43_11175	COG5413	integral membrane protein
WM43_11185	COG1522	sequence-specific DNA binding
WM43_11190	COG2502	aspartate--ammonia ligase
WM43_11195	COG0542	response to heat
WM43_11205	COG0564	pseudouridine synthase activity
WM43_11210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM43_11215	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM43_11225	COG3681	Belongs to the UPF0597 family
WM43_11230	COG2964	Protein conserved in bacteria
WM43_11240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WM43_11245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WM43_11250	COG1979	alcohol dehydrogenase
WM43_11255	COG2207	Transcriptional regulator
WM43_11260	COG3040	lipid binding
WM43_11275	COG0583	DNA-binding transcription factor activity
WM43_11290	COG0540	Belongs to the ATCase OTCase family
WM43_11295	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WM43_11300	COG1438	arginine binding
WM43_11305	COG1288	antiporter activity
WM43_11310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WM43_11335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WM43_11345	COG3078	GTPase activator activity
WM43_11360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WM43_11375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WM43_11380	COG0408	coproporphyrinogen oxidase activity
WM43_11385	COG0009	L-threonylcarbamoyladenylate synthase
WM43_11395	COG0551	DNA topoisomerase type I activity
WM43_11400	COG2922	Belongs to the Smg family
WM43_11405	COG0758	DNA mediated transformation
WM43_11410	COG1652	LysM domain
WM43_11415	COG0242	peptide deformylase activity
WM43_11420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WM43_11425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WM43_11425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WM43_11430	COG0569	domain protein
WM43_11435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WM43_11445	COG0174	glutamine synthetase
WM43_11455	COG3852	Histidine kinase
WM43_11465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WM43_11470	COG1322	Protein conserved in bacteria
WM43_11490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WM43_11495	COG0583	DNA-binding transcription factor activity
WM43_11500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WM43_11500	COG0519	Catalyzes the synthesis of GMP from XMP
WM43_11515	COG1396	sequence-specific DNA binding
WM43_11520	COG1012	belongs to the aldehyde dehydrogenase family
WM43_11525	COG2962	Rard protein
WM43_11535	COG2391	methyltransferase activity
WM43_11550	COG0129	dihydroxy-acid dehydratase activity
WM43_11555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WM43_11560	COG3978	acetolactate synthase activity
WM43_11570	COG0606	chelatase, subunit chli
WM43_11575	COG0204	Acyl-transferase
WM43_11580	COG0204	Acyl-transferase
WM43_11585	COG1683	Conserved Protein
WM43_11595	COG1335	isochorismatase
WM43_11605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WM43_11610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WM43_11620	COG3084	Protein conserved in bacteria
WM43_11625	COG4251	negative regulation of phosphorylation
WM43_11625	COG2203	Gaf domain
WM43_11625	COG5001	Diguanylate cyclase
WM43_11625	COG3706	GGDEF domain
WM43_11640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WM43_11645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WM43_11650	COG1561	YicC-like family, N-terminal region
WM43_11655	COG0583	DNA-binding transcription factor activity
WM43_11670	COG0583	DNA-binding transcription factor activity
WM43_11710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WM43_11715	COG0385	Bile acid
WM43_11720	COG0531	amino acid
WM43_11725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WM43_11730	COG0531	amino acid
WM43_11735	COG2731	YhcH YjgK YiaL family protein
WM43_11740	COG3250	beta-galactosidase activity
WM43_11745	COG1609	Transcriptional regulator
WM43_11780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WM43_11790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WM43_11795	COG3074	FtsZ-dependent cytokinesis
WM43_11805	COG1045	serine acetyltransferase
WM43_11815	COG0745	RESPONSE REGULATOR receiver
WM43_11820	COG2205	protein histidine kinase activity
WM43_11825	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WM43_11830	COG0534	Mate efflux family protein
WM43_11845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WM43_11850	COG2937	Belongs to the GPAT DAPAT family
WM43_11855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WM43_11860	COG3161	chorismate lyase activity
WM43_11880	COG0604	alcohol dehydrogenase
WM43_11885	COG1609	Transcriptional regulator
WM43_11890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_11905	COG1519	Transferase
WM43_11910	COG0859	PFAM glycosyl transferase family 9
WM43_11915	COG0463	Glycosyl transferase, family 2
WM43_11920	COG0859	PFAM glycosyl transferase family 9
WM43_11925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WM43_11930	COG2990	Protein conserved in bacteria
WM43_11935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WM43_11945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WM43_11950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WM43_11955	COG2003	Belongs to the UPF0758 family
WM43_11960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WM43_11965	COG0756	dUTP diphosphatase activity
WM43_11970	COG1309	transcriptional regulator
WM43_11975	COG0668	transmembrane transport
WM43_11980	COG0166	Belongs to the GPI family
WM43_11985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WM43_11990	COG0583	DNA-binding transcription factor activity
WM43_12005	COG1042	CoA-binding domain protein
WM43_12005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WM43_12005	COG0045	succinate-CoA ligase (ADP-forming) activity
WM43_12035	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WM43_12040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WM43_12045	COG1739	Uncharacterized protein family UPF0029
WM43_12050	COG0006	proline dipeptidase activity
WM43_12055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WM43_12060	COG1250	3-hydroxyacyl-CoA dehydrogenase
WM43_12060	COG1024	Enoyl-CoA hydratase
WM43_12065	COG0183	Belongs to the thiolase family
WM43_12070	COG0745	RESPONSE REGULATOR receiver
WM43_12075	COG2205	protein histidine kinase activity
WM43_12090	COG0425	Belongs to the sulfur carrier protein TusA family
WM43_12095	COG0251	oxidation-reduction process
WM43_12100	COG2885	chlorophyll binding
WM43_12105	COG2818	Glycosylase
WM43_12110	COG0752	glycyl-tRNA synthetase alpha subunit
WM43_12115	COG0751	glycine-tRNA ligase activity
WM43_12125	COG2200	EAL domain
WM43_12135	COG0840	transmembrane signaling receptor activity
WM43_12140	COG2188	Transcriptional regulator
WM43_12155	COG1609	Transcriptional regulator
WM43_12165	COG0559	Belongs to the binding-protein-dependent transport system permease family
WM43_12185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WM43_12200	COG2960	long-chain fatty acid transporting porin activity
WM43_12205	COG5001	Diguanylate cyclase
WM43_12215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WM43_12225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WM43_12230	COG3118	belongs to the thioredoxin family
WM43_12235	COG0513	Belongs to the DEAD box helicase family
WM43_12240	COG0248	Ppx GppA phosphatase
WM43_12250	COG0742	ribosomal rna small subunit methyltransferase
WM43_12265	COG3469	chitinase activity
WM43_12270	COG3397	chitin binding
WM43_12280	COG0084	hydrolase, TatD family'
WM43_12285	COG0805	protein transport
WM43_12290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM43_12295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WM43_12300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WM43_12305	COG3165	ubiquinone biosynthetic process from chorismate
WM43_12310	COG2226	methyltransferase
WM43_12315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WM43_12320	COG0402	S-adenosylhomocysteine deaminase activity
WM43_12325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WM43_12365	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WM43_12370	COG0848	biopolymer transport protein
WM43_12375	COG0811	peptide transport
WM43_12380	COG0811	peptide transport
WM43_12390	COG2771	luxR family
WM43_12395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WM43_12400	COG1349	DNA-binding transcription factor activity
WM43_12405	COG0745	RESPONSE REGULATOR receiver
WM43_12410	COG2205	protein histidine kinase activity
WM43_12425	COG4452	Inner membrane protein CreD
WM43_12440	COG0297	glycogen (starch) synthase activity
WM43_12440	COG0438	transferase activity, transferring glycosyl groups
WM43_12485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WM43_12490	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WM43_12495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WM43_12500	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WM43_12505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WM43_12510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WM43_12515	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WM43_12520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WM43_12530	COG0356	it plays a direct role in the translocation of protons across the membrane
WM43_12540	COG1475	DNA binding
WM43_12545	COG1192	Involved in chromosome partitioning
WM43_12550	COG0357	Ribosomal RNA small subunit methyltransferase G
WM43_12555	COG0445	tRNA wobble uridine modification
WM43_12560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WM43_12570	COG4615	Cyclic peptide transporter
WM43_12575	COG1120	ATPase activity
WM43_12580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM43_12590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WM43_12595	COG0706	membrane insertase activity
WM43_12600	COG0594	ribonuclease P activity
WM43_12605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WM43_12625	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WM43_12630	COG0592	DNA-directed DNA polymerase activity
WM43_12640	COG0187	DNA topoisomerase II activity
WM43_12650	COG2378	regulation of single-species biofilm formation
WM43_12660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WM43_12665	COG0071	Belongs to the small heat shock protein (HSP20) family
WM43_12670	COG0071	Belongs to the small heat shock protein (HSP20) family
WM43_12675	COG3977	Valine--pyruvate aminotransferase
WM43_12690	COG2814	Major facilitator Superfamily
WM43_12695	COG0745	RESPONSE REGULATOR receiver
WM43_12700	COG2205	protein histidine kinase activity
WM43_12720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WM43_12725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_12725	COG4191	Histidine kinase
WM43_12730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM43_12735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_12740	COG1309	transcriptional regulator
WM43_12770	COG0561	phosphatase activity
WM43_12775	COG2267	carboxylic ester hydrolase activity
WM43_12785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WM43_12790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM43_12795	COG1758	RNA polymerase activity
WM43_12800	COG0194	GDP metabolic process
WM43_12810	COG0859	PFAM glycosyl transferase family 9
WM43_12815	COG3642	lipopolysaccharide core region biosynthetic process
WM43_12850	COG0589	response to stress
WM43_12855	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WM43_12860	COG1528	Iron-storage protein
WM43_12865	COG2081	HI0933 family
WM43_12870	COG3275	phosphorelay sensor kinase activity
WM43_12875	COG3279	Response regulator of the LytR AlgR family
WM43_12880	COG2223	nitrite transmembrane transporter activity
WM43_12885	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WM43_12890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WM43_12905	COG0583	DNA-binding transcription factor activity
WM43_12910	COG4206	TonB-dependent receptor
WM43_12915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WM43_12950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WM43_12955	COG2166	iron-sulfur cluster assembly
WM43_12960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WM43_12975	COG3245	cytochrome
WM43_12980	COG1063	alcohol dehydrogenase
WM43_12995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WM43_13000	COG0438	transferase activity, transferring glycosyl groups
WM43_13060	COG0210	DNA helicase
WM43_13085	COG0737	Belongs to the 5'-nucleotidase family
WM43_13095	COG2239	Acts as a magnesium transporter
WM43_13100	COG1648	precorrin-2 dehydrogenase activity
WM43_13100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WM43_13105	COG2116	formate transmembrane transporter activity
WM43_13110	COG2146	nitrite reductase [NAD(P)H] activity
WM43_13115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WM43_13120	COG0842	Transport permease protein
WM43_13125	COG0842	Transport permease protein
WM43_13130	COG1131	(ABC) transporter
WM43_13135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_13145	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WM43_13150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WM43_13160	COG0018	arginyl-trna synthetase
WM43_13170	COG1595	DNA-templated transcription, initiation
WM43_13180	COG1968	undecaprenyl-diphosphatase activity
WM43_13185	COG2017	converts alpha-aldose to the beta-anomer
WM43_13190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WM43_13200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WM43_13205	COG1609	Transcriptional regulator
WM43_13210	COG3250	beta-galactosidase activity
WM43_13220	COG1129	ABC transporter
WM43_13225	COG4211	Belongs to the binding-protein-dependent transport system permease family
WM43_13235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WM43_13250	COG0366	Alpha amylase catalytic
WM43_13265	COG0443	Heat shock 70 kDa protein
WM43_13270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WM43_13275	COG3045	CreA protein
WM43_13290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM43_13295	COG0174	glutamine synthetase
WM43_13315	COG3842	ATPase activity
WM43_13320	COG1176	ABC-type spermidine putrescine transport system, permease component I
WM43_13325	COG1177	transmembrane transport
WM43_13330	COG2258	MOSC domain
WM43_13345	COG2050	protein possibly involved in aromatic compounds catabolism
WM43_13350	COG0514	ATP-dependent DNA helicase (RecQ)
WM43_13360	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WM43_13370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WM43_13375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WM43_13390	COG0254	rRNA binding
WM43_13395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WM43_13405	COG0702	epimerase
WM43_13410	COG0814	amino acid
WM43_13415	COG0281	malic enzyme
WM43_13420	COG1295	ribonuclease BN
WM43_13425	COG1490	D-aminoacyl-tRNA deacylase activity
WM43_13430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WM43_13435	COG0456	acetyltransferase
WM43_13445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WM43_13450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WM43_13455	COG2610	gluconate transmembrane transporter activity
WM43_13460	COG3265	gluconokinase activity
WM43_13465	COG0129	dihydroxy-acid dehydratase activity
WM43_13470	COG0800	Aldolase
WM43_13475	COG1609	Transcriptional regulator
WM43_13485	COG4942	peptidase
WM43_13490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WM43_13495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WM43_13500	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WM43_13505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WM43_13510	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WM43_13510	COG0316	Belongs to the HesB IscA family
WM43_13515	COG1040	competence protein
WM43_13520	COG0596	Alpha beta hydrolase
WM43_13540	COG2183	response to ionizing radiation
WM43_13545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WM43_13550	COG0745	RESPONSE REGULATOR receiver
WM43_13565	COG0051	transcription antitermination factor activity, RNA binding
WM43_13570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WM43_13575	COG0088	Forms part of the polypeptide exit tunnel
WM43_13580	COG0089	rRNA binding
WM43_13585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WM43_13590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WM43_13595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WM43_13600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WM43_13605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WM43_13610	COG0255	Belongs to the universal ribosomal protein uL29 family
WM43_13615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WM43_13620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WM43_13625	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WM43_13630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WM43_13635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WM43_13640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WM43_13645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WM43_13650	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WM43_13655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WM43_13660	COG1841	ribosomal large subunit assembly
WM43_13665	COG0200	Binds to the 23S rRNA
WM43_13670	COG0201	protein transport
WM43_13675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WM43_13680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WM43_13685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WM43_13690	COG0202	RNA polymerase activity
WM43_13695	COG0203	ribosomal protein L17
WM43_13725	COG4771	TonB-dependent receptor
WM43_13740	COG0745	RESPONSE REGULATOR receiver
WM43_13755	COG0583	DNA-binding transcription factor activity
WM43_13765	COG1741	Belongs to the pirin family
WM43_13770	COG2259	Doxx family
WM43_13775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WM43_13780	COG1074	ATP-dependent DNA helicase activity
WM43_13785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WM43_13795	COG5433	transposase activity
WM43_13805	COG3706	GGDEF domain
WM43_13835	COG1175	transmembrane transport
WM43_13845	COG3842	ATPase activity
WM43_13875	COG2873	o-acetylhomoserine
WM43_13880	COG4533	DNA binding
WM43_13885	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WM43_13900	COG5380	lipid catabolic process
WM43_13905	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WM43_13910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WM43_13935	COG0753	catalase activity
WM43_13965	COG2927	DNA polymerase III (CHI subunit)
WM43_13970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WM43_13975	COG0795	lipopolysaccharide-transporting ATPase activity
WM43_13980	COG0795	lipopolysaccharide-transporting ATPase activity
WM43_13995	COG0582	viral genome integration into host DNA
WM43_14030	COG0531	amino acid
WM43_14050	COG1494	fructose-1,6-bisphosphatase
WM43_14065	COG2959	enzyme of heme biosynthesis
WM43_14075	COG0181	hydroxymethylbilane synthase activity
WM43_14080	COG3072	Adenylate cyclase
WM43_14085	COG0400	carboxylic ester hydrolase activity
WM43_14090	COG1965	Belongs to the frataxin family
WM43_14095	COG0019	diaminopimelate decarboxylase activity
WM43_14100	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WM43_14110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WM43_14115	COG1011	Hydrolase
WM43_14135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WM43_14140	COG3028	Belongs to the UPF0307 family
WM43_14160	COG0328	RNA-DNA hybrid ribonuclease activity
WM43_14210	COG2801	Transposase and inactivated derivatives
WM43_14215	COG2963	transposase activity
WM43_14225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WM43_14255	COG0312	modulator of DNA gyrase
WM43_14260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WM43_14265	COG5007	Belongs to the BolA IbaG family
WM43_14275	COG2854	intermembrane phospholipid transfer
WM43_14280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM43_14285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WM43_14290	COG1127	ABC transporter
WM43_14295	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WM43_14295	COG0517	IMP dehydrogenase activity
WM43_14300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WM43_14305	COG3117	lipopolysaccharide transmembrane transporter activity
WM43_14310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WM43_14315	COG1137	ATPase activity
WM43_14330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_14335	COG1660	Displays ATPase and GTPase activities
WM43_14340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_14345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_14345	COG3711	transcriptional antiterminator
WM43_14360	COG3964	amidohydrolase
WM43_14390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM43_14395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WM43_14405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WM43_14410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WM43_14415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WM43_14420	COG0723	plastoquinol--plastocyanin reductase activity
WM43_14425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WM43_14430	COG2857	Cytochrome c1
WM43_14435	COG0625	glutathione transferase activity
WM43_14440	COG2969	positive regulation of protein catabolic process
WM43_14445	COG2823	Periplasmic or secreted lipoprotein
WM43_14450	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WM43_14455	COG0792	nuclease activity
WM43_14460	COG3107	peptidoglycan biosynthetic process
WM43_14465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WM43_14475	COG2001	Belongs to the MraZ family
WM43_14480	COG0275	rRNA processing
WM43_14485	COG3116	cell division
WM43_14490	COG0768	penicillin binding
WM43_14500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WM43_14505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WM43_14510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WM43_14515	COG0772	Belongs to the SEDS family
WM43_14520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WM43_14525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WM43_14535	COG0849	cell division
WM43_14540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WM43_14545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WM43_14555	COG0653	protein targeting
WM43_14560	COG0494	nUDIX hydrolase
WM43_14565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WM43_14570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WM43_14580	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WM43_14585	COG1459	type II secretion system
WM43_14590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WM43_14600	COG5433	transposase activity
WM43_14620	COG2186	Transcriptional regulator
WM43_14625	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WM43_14630	COG0508	dehydrogenase complex catalyzes the overall conversion of
WM43_14635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WM43_14645	COG0840	transmembrane signaling receptor activity
WM43_14650	COG1752	Esterase of the alpha-beta hydrolase superfamily
WM43_14655	COG1049	propionate catabolic process, 2-methylcitrate cycle
WM43_14660	COG2200	EAL domain
WM43_14670	COG0523	cobalamin synthesis protein
WM43_14675	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM43_14690	COG2814	Major facilitator Superfamily
WM43_14705	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WM43_14710	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WM43_14745	COG3039	Transposase
WM43_14760	COG0165	Argininosuccinate lyase
WM43_14765	COG0137	argininosuccinate synthase activity
WM43_14775	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WM43_14780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WM43_14790	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WM43_14795	COG0110	maltose O-acetyltransferase activity
WM43_14810	COG0814	amino acid
WM43_14815	COG3932	Exopolysaccharide synthesis, ExoD
WM43_14825	COG3706	GGDEF domain
WM43_14830	COG0004	ammonium transporteR
WM43_14835	COG3133	Outer membrane lipoprotein
WM43_14840	COG0456	acetyltransferase
WM43_14865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WM43_14880	COG0671	phosphoesterase, PA-phosphatase related
WM43_14885	COG0628	permease
WM43_14905	COG3284	Transcriptional regulator
WM43_14915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WM43_14915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_14915	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
WM43_14920	COG1461	Dihydroxyacetone kinase
WM43_14925	COG2376	Dihydroxyacetone kinase
WM43_14930	COG2252	PERMEase
WM43_14935	COG1278	Cold shock
WM43_14945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WM43_14955	COG3039	Transposase
WM43_14965	COG1484	DNA-dependent DNA replication
WM43_14970	COG4584	PFAM Integrase catalytic
WM43_14975	COG1061	Type III restriction enzyme res subunit
WM43_14980	COG5433	transposase activity
WM43_15005	COG2801	Transposase and inactivated derivatives
WM43_15010	COG2963	transposase activity
WM43_15035	COG1396	sequence-specific DNA binding
WM43_15045	COG2801	Transposase and inactivated derivatives
WM43_15070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WM43_15100	COG2197	response regulator
WM43_15115	COG1462	curli production assembly transport component CsgG
WM43_15120	COG3385	transposase activity
WM43_15140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WM43_15145	COG3706	GGDEF domain
WM43_15150	COG3047	cAMP biosynthetic process
WM43_15155	COG0840	transmembrane signaling receptor activity
WM43_15165	COG3385	transposase activity
WM43_15185	COG3135	benzoate transporter
WM43_15190	COG1396	sequence-specific DNA binding
WM43_15230	COG2926	Belongs to the UPF0265 family
WM43_15240	COG0561	phosphatase activity
WM43_15250	COG1546	Belongs to the CinA family
WM43_15250	COG1058	Belongs to the CinA family
WM43_15260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WM43_15270	COG1522	sequence-specific DNA binding
WM43_15275	COG1368	sulfuric ester hydrolase activity
WM43_15310	COG4221	oxidoreductase activity
WM43_15325	COG1979	alcohol dehydrogenase
WM43_15330	COG1803	Methylglyoxal synthase
WM43_15355	COG1444	tRNA N-acetyltransferase activity
WM43_15360	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_15365	COG0835	chemotaxis
WM43_15365	COG0784	Response regulator, receiver
WM43_15375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WM43_15380	COG2949	membrane
WM43_15385	COG3291	Pkd domain containing protein
WM43_15390	COG2801	Transposase and inactivated derivatives
WM43_15395	COG2963	transposase activity
WM43_15400	COG3039	Transposase
WM43_15410	COG0318	PFAM AMP-dependent synthetase and ligase
WM43_15415	COG1441	menaquinone biosynthetic process
WM43_15420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WM43_15425	COG0596	Alpha beta hydrolase
WM43_15430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WM43_15435	COG1169	isochorismate synthase
WM43_15440	COG1575	Belongs to the MenA family. Type 1 subfamily
WM43_15460	COG0513	Belongs to the DEAD box helicase family
WM43_15465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WM43_15470	COG1988	membrane-bound metal-dependent
WM43_15475	COG1671	Belongs to the UPF0178 family
WM43_15495	COG0484	heat shock protein binding
WM43_15500	COG3263	regulation of cellular component size
WM43_15505	COG3722	fumarate hydratase activity
WM43_15510	COG0246	Mannitol dehydrogenase
WM43_15515	COG2213	PTS system mannitol-specific
WM43_15515	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_15520	COG1560	Kdo2-lipid A biosynthetic process
WM43_15525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WM43_15525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WM43_15530	COG1538	Outer membrane efflux protein
WM43_15535	COG0494	nUDIX hydrolase
WM43_15540	COG3151	Protein conserved in bacteria
WM43_15550	COG3150	esterase
WM43_15555	COG1051	belongs to the nudix hydrolase family
WM43_15565	COG1566	PFAM secretion protein HlyD family protein
WM43_15570	COG1289	transmembrane transporter activity
WM43_15575	COG0187	DNA topoisomerase II activity
WM43_15600	COG0583	DNA-binding transcription factor activity
WM43_15610	COG3104	oligopeptide transport
WM43_15645	COG0583	DNA-binding transcription factor activity
WM43_15650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM43_15670	COG0204	Acyl-transferase
WM43_15675	COG1842	Phage shock protein A
WM43_15690	COG2827	Endonuclease containing a URI domain
WM43_15705	COG1573	uracil-dna glycosylase
WM43_15710	COG0697	spore germination
WM43_15715	COG0583	DNA-binding transcription factor activity
WM43_15720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WM43_15725	COG1121	(ABC) transporter
WM43_15730	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WM43_15750	COG0739	heme binding
WM43_15760	COG3068	Protein conserved in bacteria
WM43_15780	COG0617	tRNA 3'-terminal CCA addition
WM43_15785	COG1194	a g-specific adenine glycosylase
WM43_15790	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WM43_15800	COG3111	PFAM Bacterial OB fold (BOF) protein
WM43_15805	COG3240	lipase activity
WM43_15810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WM43_15810	COG2885	chlorophyll binding
WM43_15815	COG3706	GGDEF domain
WM43_15820	COG0557	exoribonuclease II activity
WM43_15835	COG2153	protein acetylation
WM43_15840	COG0513	Belongs to the DEAD box helicase family
WM43_15845	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WM43_15875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WM43_15880	COG0840	transmembrane signaling receptor activity
WM43_15890	COG4166	transmembrane transport
WM43_15900	COG0110	maltose O-acetyltransferase activity
WM43_15910	COG1024	Enoyl-CoA hydratase
WM43_15925	COG4221	oxidoreductase activity
WM43_15930	COG0442	prolyl-tRNA aminoacylation
WM43_15935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WM43_15945	COG3008	intermembrane lipid transfer
WM43_15945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WM43_15950	COG2995	paraquat-inducible protein a
WM43_15960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM43_15970	COG2203	Gaf domain
WM43_15970	COG4251	negative regulation of phosphorylation
WM43_15970	COG5001	Diguanylate cyclase
WM43_15970	COG3706	GGDEF domain
WM43_15975	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WM43_15985	COG3916	Acyl-homoserine-lactone synthase
WM43_15990	COG2771	luxR family
WM43_16000	COG0840	transmembrane signaling receptor activity
WM43_16005	COG0632	four-way junction helicase activity
WM43_16010	COG2255	four-way junction helicase activity
WM43_16020	COG1294	oxidase, subunit
WM43_16025	COG4890	Cyd operon protein YbgT
WM43_16035	COG0824	Thioesterase
WM43_16040	COG0811	peptide transport
WM43_16055	COG0823	Involved in the tonB-independent uptake of proteins
WM43_16060	COG2885	chlorophyll binding
WM43_16065	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WM43_16130	COG0733	neurotransmitter:sodium symporter activity
WM43_16140	COG0733	neurotransmitter:sodium symporter activity
WM43_16155	COG0561	phosphatase activity
WM43_16170	COG1522	sequence-specific DNA binding
WM43_16205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WM43_16210	COG1640	4-alpha-glucanotransferase
WM43_16215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WM43_16220	COG0676	glucose-6-phosphate 1-epimerase activity
WM43_16225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WM43_16230	COG0840	transmembrane signaling receptor activity
WM43_16235	COG1585	Membrane protein implicated in regulation of membrane protease activity
WM43_16240	COG0330	HflC and HflK could
WM43_16245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WM43_16245	COG1648	precorrin-2 dehydrogenase activity
WM43_16250	COG0175	sulfate reduction
WM43_16255	COG2895	sulfate adenylyltransferase (ATP) activity
WM43_16260	COG0471	metal ion transport
WM43_16260	COG3273	potassium ion transport
WM43_16265	COG0529	Catalyzes the synthesis of activated sulfate
WM43_16290	COG0840	transmembrane signaling receptor activity
WM43_16325	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WM43_16340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WM43_16345	COG3437	response regulator, receiver
WM43_16345	COG0784	Response regulator, receiver
WM43_16355	COG2076	Multidrug Resistance protein
WM43_16360	COG2076	Multidrug Resistance protein
WM43_16365	COG0346	lactoylglutathione lyase activity
WM43_16370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WM43_16375	COG1643	Atp-dependent helicase
WM43_16385	COG1489	DNA binding
WM43_16390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WM43_16395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WM43_16405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WM43_16410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WM43_16415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WM43_16445	COG1924	4 iron, 4 sulfur cluster binding
WM43_16450	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WM43_16455	COG0842	Transport permease protein
WM43_16460	COG1131	(ABC) transporter
WM43_16475	COG0163	prenyltransferase activity
WM43_16480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WM43_16485	COG0671	phosphoesterase, PA-phosphatase related
WM43_16490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WM43_16495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WM43_16500	COG1151	hydroxylamine reductase activity
WM43_16505	COG0783	Belongs to the Dps family
WM43_16510	COG3023	N-Acetylmuramoyl-L-alanine amidase
WM43_16515	COG4807	Protein conserved in bacteria
WM43_16525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WM43_16530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WM43_16535	COG3956	TIGRFAM MazG family protein
WM43_16540	COG0504	CTP synthase activity
WM43_16545	COG0148	phosphopyruvate hydratase activity
WM43_16560	COG3039	Transposase
WM43_16570	COG3039	Transposase
WM43_16595	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WM43_16605	COG0488	(ABC) transporter
WM43_16625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WM43_16640	COG1794	racemase activity, acting on amino acids and derivatives
WM43_16650	COG2731	YhcH YjgK YiaL family protein
WM43_16660	COG0668	transmembrane transport
WM43_16665	COG1376	ErfK ybiS ycfS ynhG family protein
WM43_16675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WM43_16680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WM43_16685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WM43_16695	COG0585	pseudouridine synthase activity
WM43_16700	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WM43_16705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WM43_16710	COG1238	metal cluster binding
WM43_16715	COG4942	peptidase
WM43_16715	COG1388	LysM domain
WM43_16725	COG1902	pentaerythritol trinitrate reductase activity
WM43_16745	COG2957	Belongs to the agmatine deiminase family
WM43_16750	COG0154	amidase activity
WM43_16770	COG0513	Belongs to the DEAD box helicase family
WM43_16775	COG2199	diguanylate cyclase activity
WM43_16775	COG2203	Gaf domain
WM43_16785	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WM43_16790	COG1858	cytochrome C peroxidase
WM43_16870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WM43_16885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM43_16890	COG4991	sh3 domain protein
WM43_16905	COG2816	NAD+ diphosphatase activity
WM43_16910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WM43_16915	COG1940	carbohydrate kinase activity
WM43_16920	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WM43_16925	COG0126	phosphoglycerate kinase activity
WM43_16930	COG0191	fructose-bisphosphate aldolase activity
WM43_16935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_16950	COG4232	protein-disulfide reductase activity
WM43_16975	COG0354	folic acid binding
WM43_16980	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WM43_16990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WM43_16995	COG1595	DNA-templated transcription, initiation
WM43_17000	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WM43_17005	COG3026	antisigma factor binding
WM43_17015	COG0481	GTPase activity
WM43_17020	COG0681	Belongs to the peptidase S26 family
WM43_17035	COG1381	Involved in DNA repair and RecF pathway recombination
WM43_17040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WM43_17050	COG2350	Protein conserved in bacteria
WM43_17055	COG2917	probably involved in intracellular septation
WM43_17060	COG0076	glutamate decarboxylase activity
WM43_17065	COG1272	protein, Hemolysin III
WM43_17070	COG2985	domain, Protein
WM43_17070	COG0569	domain protein
WM43_17090	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WM43_17115	COG1858	cytochrome C peroxidase
WM43_17125	COG2313	pseudouridylate synthase activity
WM43_17130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WM43_17160	COG2801	Transposase and inactivated derivatives
WM43_17165	COG2963	transposase activity
WM43_17175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WM43_17180	COG1765	OsmC-like protein
WM43_17195	COG3954	Phosphoribulokinase
WM43_17200	COG3089	Belongs to the UPF0270 family
WM43_17205	COG3706	GGDEF domain
WM43_17205	COG2203	Gaf domain
WM43_17205	COG5001	Diguanylate cyclase
WM43_17205	COG4251	negative regulation of phosphorylation
WM43_17210	COG0429	hydrolase of the alpha beta-hydrolase fold
WM43_17215	COG0835	chemotaxis
WM43_17215	COG0784	Response regulator, receiver
WM43_17225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WM43_17230	COG1047	Peptidyl-prolyl cis-trans
WM43_17245	COG0305	Participates in initiation and elongation during chromosome replication
WM43_17250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WM43_17255	COG0432	Pfam Uncharacterised protein family UPF0047
WM43_17275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM43_17285	COG3721	Heme iron utilization protein
WM43_17290	COG0748	coenzyme F420 binding
WM43_17315	COG2814	Major facilitator Superfamily
WM43_17325	COG3655	Transcriptional regulator
WM43_17335	COG0784	Response regulator, receiver
WM43_17335	COG5002	protein histidine kinase activity
WM43_17335	COG2205	protein histidine kinase activity
WM43_17345	COG3706	GGDEF domain
WM43_17360	COG3397	chitin binding
WM43_17400	COG0784	Response regulator, receiver
WM43_17400	COG0835	chemotaxis
WM43_17405	COG2755	lipolytic protein G-D-S-L family
WM43_17410	COG4181	ATPase activity
WM43_17415	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WM43_17420	COG1090	epimerase
WM43_17425	COG2200	EAL domain
WM43_17430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WM43_17435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WM43_17440	COG3171	Protein conserved in bacteria
WM43_17445	COG2066	Belongs to the glutaminase family
WM43_17450	COG2897	thiosulfate sulfurtransferase activity
WM43_17465	COG0521	Mo-molybdopterin cofactor biosynthetic process
WM43_17475	COG2966	Psort location CytoplasmicMembrane, score
WM43_17480	COG3610	response to peptide
WM43_17495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WM43_17500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WM43_17505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WM43_17510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WM43_17520	COG0786	glutamate:sodium symporter activity
WM43_17525	COG0252	asparaginase activity
WM43_17530	COG3139	Protein of unknown function (DUF1315)
WM43_17550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WM43_17555	COG0321	lipoyl(octanoyl) transferase activity
WM43_17560	COG2921	Belongs to the UPF0250 family
WM43_17565	COG1686	Belongs to the peptidase S11 family
WM43_17570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WM43_17575	COG2951	lytic endotransglycosylase activity
WM43_17580	COG0772	Belongs to the SEDS family
WM43_17585	COG0768	penicillin binding
WM43_17590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WM43_17595	COG0799	negative regulation of ribosome biogenesis
WM43_17600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WM43_17615	COG0495	leucyl-tRNA aminoacylation
WM43_17620	COG2888	peptidyl-tyrosine sulfation
WM43_17625	COG0312	modulator of DNA gyrase
WM43_17630	COG0312	modulator of DNA gyrase
WM43_17635	COG0716	FMN binding
WM43_17640	COG4974	Belongs to the 'phage' integrase family
WM43_17650	COG1970	mechanosensitive ion channel activity
WM43_17660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WM43_17665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WM43_17670	COG4535	Mg2 and Co2 transporter CorC
WM43_17675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WM43_17680	COG1702	phosphate starvation-inducible protein PhoH
WM43_17685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WM43_17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM43_17695	COG1335	isochorismatase
WM43_17700	COG3706	GGDEF domain
WM43_17705	COG0583	DNA-binding transcription factor activity
WM43_17730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WM43_17740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WM43_17750	COG0516	GMP reductase activity
WM43_17760	COG0642	Histidine kinase
WM43_17765	COG0745	RESPONSE REGULATOR receiver
WM43_17775	COG4221	oxidoreductase activity
WM43_17800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WM43_17815	COG3214	Protein conserved in bacteria
WM43_17825	COG2195	Cleaves the N-terminal amino acid of tripeptides
WM43_17830	COG0700	Nucleoside recognition
WM43_17835	COG3366	ferrous iron transmembrane transporter activity
WM43_17840	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WM43_17845	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WM43_17850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WM43_17855	COG1053	succinate dehydrogenase
WM43_17865	COG0584	glycerophosphoryl diester phosphodiesterase
WM43_17870	COG1511	domain protein
WM43_17870	COG3264	Mechanosensitive ion channel
WM43_17880	COG0739	heme binding
WM43_17890	COG0583	DNA-binding transcription factor activity
WM43_17910	COG0583	DNA-binding transcription factor activity
WM43_17915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WM43_17945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WM43_17950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WM43_17960	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WM43_17965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WM43_17975	COG0180	Tryptophanyl-tRNA synthetase
WM43_17990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WM43_18000	COG1012	belongs to the aldehyde dehydrogenase family
WM43_18015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WM43_18025	COG0674	pyruvate-flavodoxin oxidoreductase activity
WM43_18025	COG1013	pyruvate-flavodoxin oxidoreductase activity
WM43_18025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_18025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WM43_18030	COG0366	Alpha amylase catalytic
WM43_18050	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
WM43_18060	COG0471	metal ion transport
WM43_18060	COG0490	domain, Protein
WM43_18105	COG0012	GTP binding
WM43_18110	COG0193	aminoacyl-tRNA hydrolase activity
WM43_18115	COG0737	Belongs to the 5'-nucleotidase family
WM43_18120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WM43_18130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WM43_18135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WM43_18140	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WM43_18145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WM43_18150	COG2890	protein-(glutamine-N5) methyltransferase activity
WM43_18160	COG2912	Transglutaminase-like superfamily
WM43_18165	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WM43_18175	COG3039	Transposase
WM43_18185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WM43_18195	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WM43_18195	COG3408	Glycogen debranching enzyme
WM43_18205	COG1881	PFAM PEBP family protein
WM43_18225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WM43_18235	COG0583	DNA-binding transcription factor activity
WM43_18240	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_18245	COG0616	signal peptide processing
WM43_18250	COG2211	Major facilitator Superfamily
WM43_18255	COG3706	GGDEF domain
WM43_18260	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WM43_18270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WM43_18300	COG3724	N-succinylarginine dihydrolase activity
WM43_18305	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WM43_18315	COG0840	transmembrane signaling receptor activity
WM43_18325	COG2971	BadF BadG BcrA BcrD
WM43_18335	COG4608	Belongs to the ABC transporter superfamily
WM43_18340	COG0444	Belongs to the ABC transporter superfamily
WM43_18345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WM43_18360	COG0784	Response regulator, receiver
WM43_18360	COG2205	protein histidine kinase activity
WM43_18390	COG3220	belongs to the UPF0276 family
WM43_18420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WM43_18425	COG1289	transmembrane transporter activity
WM43_18430	COG0303	'Molybdopterin
WM43_18435	COG0746	molybdenum cofactor guanylyltransferase activity
WM43_18445	COG4662	Binding-protein-dependent transport system inner membrane component
WM43_18455	COG2204	response regulator
WM43_18460	COG3852	Histidine kinase
WM43_18470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WM43_18475	COG3039	Transposase
WM43_18505	COG3383	formate dehydrogenase (NAD+) activity
WM43_18505	COG3383	formate dehydrogenase (NAD+) activity
WM43_18510	COG0437	4 iron, 4 sulfur cluster binding
WM43_18530	COG0281	malic enzyme
WM43_18550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_18580	COG0837	glucose binding
WM43_18585	COG1737	Transcriptional regulator
WM43_18590	COG0469	pyruvate kinase activity
WM43_18610	COG1677	Flagellar hook-basal body complex protein FliE
WM43_18620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WM43_18670	COG1987	bacterial-type flagellum assembly
WM43_18675	COG1684	flagellar biosynthetic protein fliR
WM43_18685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WM43_18695	COG0455	bacterial-type flagellum organization
WM43_18710	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WM43_18715	COG2198	Histidine kinase
WM43_18715	COG0643	Histidine kinase
WM43_18725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WM43_18730	COG1360	Flagellar Motor Protein
WM43_18735	COG1192	Involved in chromosome partitioning
WM43_18745	COG0835	chemotaxis
WM43_18760	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM43_18765	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM43_18770	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WM43_18775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WM43_18780	COG1138	Cytochrome C-type biogenesis protein
WM43_18785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WM43_18790	COG4235	cytochrome complex assembly
WM43_18790	COG3088	subunit of a heme lyase
WM43_18800	COG2853	Lipoprotein
WM43_18805	COG3385	transposase activity
WM43_18815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WM43_18830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WM43_18840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WM43_18845	COG1882	Formate acetyltransferase
WM43_18855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WM43_18855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WM43_18875	COG5433	transposase activity
WM43_18885	COG2963	transposase activity
WM43_18890	COG2801	Transposase and inactivated derivatives
WM43_18900	COG3039	Transposase
WM43_18910	COG0259	pyridoxamine-phosphate oxidase activity
WM43_18915	COG0625	glutathione transferase activity
WM43_18935	COG2850	peptidyl-arginine hydroxylation
WM43_18940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WM43_18945	COG2915	High frequency lysogenization protein hflD homolog
WM43_18950	COG0482	sulfurtransferase activity
WM43_18960	COG1187	pseudouridine synthase activity
WM43_18970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_18975	COG2271	Major facilitator Superfamily
WM43_18980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_18980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WM43_18980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_19000	COG3039	Transposase
WM43_19010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WM43_19020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM43_19025	COG1960	acyl-CoA dehydrogenase activity
WM43_19035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WM43_19045	COG3383	formate dehydrogenase (NAD+) activity
WM43_19055	COG0784	Response regulator, receiver
WM43_19055	COG2205	protein histidine kinase activity
WM43_19065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WM43_19070	COG2867	negative regulation of translational initiation
WM43_19080	COG1473	amidohydrolase
WM43_19085	COG1960	acyl-CoA dehydrogenase activity
WM43_19090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WM43_19095	COG0121	glutamine amidotransferase
WM43_19125	COG2197	response regulator
WM43_19130	COG3850	Histidine kinase
WM43_19135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WM43_19140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WM43_19150	COG0243	molybdopterin cofactor binding
WM43_19155	COG0437	4 iron, 4 sulfur cluster binding
WM43_19160	COG0348	domain, Protein
WM43_19170	COG3005	denitrification pathway
WM43_19175	COG0521	Mo-molybdopterin cofactor biosynthetic process
WM43_19180	COG0315	cyclic pyranopterin monophosphate synthase activity
WM43_19185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WM43_19190	COG0314	molybdopterin synthase activity
WM43_19205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WM43_19210	COG2267	carboxylic ester hydrolase activity
WM43_19215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WM43_19220	COG0303	'Molybdopterin
WM43_19225	COG0302	gtp cyclohydrolase
WM43_19230	COG0840	transmembrane signaling receptor activity
WM43_19235	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WM43_19245	COG0583	DNA-binding transcription factor activity
WM43_19250	COG2353	YceI-like domain
WM43_19260	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WM43_19275	COG2195	Cleaves the N-terminal amino acid of tripeptides
WM43_19280	COG1166	arginine decarboxylase activity
WM43_19290	COG2015	COG2015, Alkyl sulfatase and related hydrolases
WM43_19310	COG0814	amino acid
WM43_19320	COG3681	Belongs to the UPF0597 family
WM43_19325	COG2964	Protein conserved in bacteria
WM43_19340	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WM43_19345	COG1288	antiporter activity
WM43_19350	COG0436	Aminotransferase
WM43_19360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WM43_19365	COG0739	heme binding
WM43_19365	COG0741	lytic transglycosylase activity
WM43_19365	COG1196	nuclear chromosome segregation
WM43_19380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WM43_19390	COG0788	formyltetrahydrofolate deformylase activity
WM43_19395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WM43_19415	COG0791	NLP P60 protein
WM43_19420	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WM43_19430	COG0471	metal ion transport
WM43_19440	COG1376	ErfK ybiS ycfS ynhG family protein
WM43_19440	COG1388	LysM domain
WM43_19470	COG0741	lytic transglycosylase activity
WM43_19470	COG1388	LysM domain
WM43_19475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WM43_19480	COG2226	methyltransferase
WM43_19485	COG0328	RNA-DNA hybrid ribonuclease activity
WM43_19490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM43_19505	COG2375	cellular response to nickel ion
WM43_19510	COG4771	TonB-dependent receptor
WM43_19515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM43_19520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WM43_19525	COG1120	ATPase activity
WM43_19540	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WM43_19545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WM43_19580	COG0708	Exodeoxyribonuclease III
WM43_19610	COG3132	Protein of unknown function, DUF480
WM43_19615	COG3300	MHYT domain
WM43_19615	COG5001	Diguanylate cyclase
WM43_19625	COG2841	Protein conserved in bacteria
WM43_19635	COG0534	Mate efflux family protein
WM43_19655	COG1454	alcohol dehydrogenase
WM43_19665	COG1309	transcriptional regulator
WM43_19700	COG3152	Membrane
WM43_19715	COG0589	response to stress
WM43_19720	COG0659	secondary active sulfate transmembrane transporter activity
WM43_19725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WM43_19735	COG0840	transmembrane signaling receptor activity
WM43_19740	COG1482	cell wall glycoprotein biosynthetic process
WM43_19745	COG2207	Transcriptional regulator
WM43_19750	COG0538	isocitrate dehydrogenase activity
WM43_19755	COG0583	DNA-binding transcription factor activity
WM43_19760	COG0791	NLP P60 protein
WM43_19765	COG0583	DNA-binding transcription factor activity
WM43_19770	COG0450	alkyl hydroperoxide reductase
WM43_19790	COG0500	methyltransferase
WM43_19795	COG4106	trans-aconitate 2-methyltransferase activity
WM43_19800	COG1801	Protein of unknown function DUF72
WM43_19805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WM43_19810	COG0217	transcriptional regulatory protein
WM43_19815	COG1454	alcohol dehydrogenase
WM43_19815	COG1012	belongs to the aldehyde dehydrogenase family
WM43_19820	COG2095	MarC family integral membrane protein
WM43_19830	COG0601	transmembrane transport
WM43_19835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WM43_19850	COG0861	Integral membrane protein TerC family
WM43_19855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WM43_19885	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WM43_19890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WM43_19895	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WM43_19900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WM43_19905	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WM43_19910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WM43_19925	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WM43_19930	COG0505	Belongs to the CarA family
WM43_19935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WM43_19945	COG0287	Prephenate dehydrogenase
WM43_19945	COG1605	Chorismate mutase
WM43_19950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WM43_19960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM43_19965	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM43_20000	COG0537	adenosine 5'-monophosphoramidase activity
WM43_20015	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WM43_20030	COG1301	dicarboxylic acid transport
WM43_20035	COG0840	transmembrane signaling receptor activity
WM43_20045	COG2354	Protein conserved in bacteria
WM43_20055	COG2233	PERMEase
WM43_20065	COG1252	NADH dehydrogenase
WM43_20075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WM43_20085	COG0446	pyridine nucleotide-disulphide oxidoreductase
WM43_20095	COG2373	Large extracellular alpha-helical protein
WM43_20100	COG4953	penicillin-binding protein 1C
WM43_20110	COG0582	viral genome integration into host DNA
WM43_20180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WM43_20235	COG0270	DNA (cytosine-5-)-methyltransferase activity
WM43_20440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WM43_20440	COG0301	tRNA thio-modification
WM43_20455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WM43_20460	COG1334	flagellar protein FlaG
WM43_20495	COG3335	DDE superfamily endonuclease
WM43_20500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WM43_20510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WM43_20520	COG3385	transposase activity
WM43_20525	COG0483	inositol monophosphate 1-phosphatase activity
WM43_20535	COG0675	Transposase, IS605 OrfB family
WM43_20545	COG0625	glutathione transferase activity
WM43_20550	COG2814	Major facilitator Superfamily
WM43_20560	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
WM43_20570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM43_20575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WM43_20580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WM43_20585	COG0509	glycine decarboxylation via glycine cleavage system
WM43_20590	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM43_20590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WM43_20610	COG3318	Belongs to the UPF0149 family
WM43_20610	COG3012	SEC-C Motif Domain Protein
WM43_20615	COG0714	Associated with various cellular activities
WM43_20625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WM43_20685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WM43_20695	COG4584	PFAM Integrase catalytic
WM43_20700	COG1484	DNA-dependent DNA replication
WM43_20705	COG0840	transmembrane signaling receptor activity
WM43_20735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WM43_20740	COG0574	Belongs to the PEP-utilizing enzyme family
WM43_20740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WM43_20755	COG1464	Belongs to the NlpA lipoprotein family
WM43_20760	COG3083	sulfuric ester hydrolase activity
WM43_20765	COG3082	Protein of unknown function (DUF1414)
WM43_20770	COG3081	Nucleoid-associated protein
WM43_20780	COG1175	transmembrane transport
WM43_20790	COG3842	ATPase activity
WM43_20815	COG0425	Belongs to the sulfur carrier protein TusA family
WM43_20820	COG4783	chaperone-mediated protein folding
WM43_20830	COG1393	Belongs to the ArsC family
WM43_20845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WM43_20850	COG2431	L-lysine efflux transmembrane transporter activity
WM43_20865	COG4215	(ABC) transporter
WM43_20870	COG4160	amino acid transport
WM43_20880	COG0564	pseudouridine synthase activity
WM43_20895	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WM43_20905	COG0625	glutathione transferase activity
WM43_20930	COG0642	Histidine kinase
WM43_20935	COG2261	transglycosylase associated protein
WM43_20945	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WM43_20955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WM43_20960	COG0215	cysteine-tRNA ligase activity
WM43_20970	COG5433	transposase activity
WM43_20985	COG2801	Transposase and inactivated derivatives
WM43_21030	COG2119	membrane
WM43_21035	COG0023	Translation Initiation Factor
WM43_21060	COG0513	Belongs to the DEAD box helicase family
WM43_21065	COG0493	'glutamate synthase
WM43_21070	COG0069	glutamate synthase activity
WM43_21070	COG0070	glutamate synthase
WM43_21070	COG0067	glutamate synthase
WM43_21080	COG1242	4 iron, 4 sulfur cluster binding
WM43_21130	COG3634	alkyl hydroperoxide reductase activity
WM43_21135	COG0450	alkyl hydroperoxide reductase
WM43_21140	COG0517	IMP dehydrogenase activity
WM43_21145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WM43_21150	COG0343	queuine tRNA-ribosyltransferase activity
WM43_21155	COG1862	Preprotein translocase
WM43_21160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM43_21165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WM43_21210	COG1104	cysteine desulfurase activity
WM43_21215	COG0822	iron-sulfur transferase activity
WM43_21225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WM43_21230	COG0443	Heat shock 70 kDa protein
WM43_21235	COG0633	Ferredoxin
WM43_21250	COG0105	UTP biosynthetic process
WM43_21255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WM43_21275	COG0124	histidyl-tRNA synthetase
WM43_21280	COG2976	Protein conserved in bacteria
WM43_21285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WM43_21290	COG1160	GTP binding
WM43_21295	COG1645	bacterial-type flagellum-dependent swarming motility
WM43_21300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WM43_21305	COG0047	phosphoribosylformylglycinamidine synthase activity
WM43_21305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WM43_21310	COG2199	diguanylate cyclase activity
WM43_21310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WM43_21325	COG1007	ATP synthesis coupled electron transport
WM43_21330	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_21340	COG0713	ATP synthesis coupled electron transport
WM43_21345	COG0839	Belongs to the complex I subunit 6 family
WM43_21350	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_21355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WM43_21360	COG1034	ATP synthesis coupled electron transport
WM43_21375	COG0649	NAD binding
WM43_21375	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_21380	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_21385	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WM43_21405	COG1770	oligopeptidase
WM43_21410	COG4771	TonB-dependent receptor
WM43_21415	COG1360	Flagellar Motor Protein
WM43_21420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WM43_21425	COG2963	transposase activity
WM43_21430	COG2801	Transposase and inactivated derivatives
WM43_21435	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WM43_21450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WM43_21460	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
WM43_21465	COG4597	amino acid ABC transporter
WM43_21470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WM43_21475	COG0765	amino acid transport
WM43_21480	COG1126	abc transporter atp-binding protein
WM43_21490	COG0724	RNA recognition motif
WM43_21495	COG4989	oxidoreductase activity
WM43_21520	COG3437	response regulator, receiver
WM43_21525	COG0583	DNA-binding transcription factor activity
WM43_21530	COG3300	MHYT domain
WM43_21530	COG5001	Diguanylate cyclase
WM43_21535	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WM43_21555	COG2814	Major facilitator Superfamily
WM43_21570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WM43_21575	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WM43_21580	COG0539	negative regulation of cytoplasmic translation
WM43_21585	COG0776	regulation of translation
WM43_21595	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WM43_21615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WM43_21645	COG0633	Ferredoxin
WM43_21795	COG5001	Diguanylate cyclase
WM43_21795	COG3300	MHYT domain
WM43_21805	COG3316	Transposase and inactivated derivatives
WM43_21810	COG3173	Aminoglycoside phosphotransferase
WM43_21825	COG3316	Transposase and inactivated derivatives
WM43_21830	COG1695	Transcriptional regulator
WM43_21920	COG4974	Belongs to the 'phage' integrase family
WM43_22060	COG0616	signal peptide processing
WM43_22110	COG0776	regulation of translation
WM43_22175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WM43_22240	COG3316	Transposase and inactivated derivatives
WM43_22245	COG2373	Large extracellular alpha-helical protein
WM43_22250	COG1983	PspC domain protein
WM43_22260	COG1842	Phage shock protein A
WM43_22265	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WM43_22275	COG1028	Short-chain dehydrogenase reductase Sdr
WM43_22280	COG1546	Belongs to the CinA family
WM43_22295	COG3111	PFAM Bacterial OB fold (BOF) protein
WM43_22305	COG4168	peptide transport system, permease
WM43_22370	COG3316	Transposase and inactivated derivatives
WM43_22380	COG1349	DNA-binding transcription factor activity
WM43_22385	COG2084	Dehydrogenase
WM43_22395	COG0235	Class ii aldolase
WM43_22400	COG3316	Transposase and inactivated derivatives
WM43_22405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WM43_22415	COG3316	Transposase and inactivated derivatives
WM43_22440	COG3316	Transposase and inactivated derivatives
WM43_22465	COG3316	Transposase and inactivated derivatives
WM43_22490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WM43_22505	COG1192	Involved in chromosome partitioning
WM43_22580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WM43_22670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WM43_22695	COG5001	Diguanylate cyclase
WM43_22730	COG0714	Associated with various cellular activities
WM43_22740	COG0629	single-stranded DNA binding