locus-tag	class	description
GRF56_00105	COG0795	lipopolysaccharide-transporting ATPase activity
GRF56_00110	COG0795	lipopolysaccharide-transporting ATPase activity
GRF56_00115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GRF56_00120	COG2927	DNA polymerase III (CHI subunit)
GRF56_00145	COG0454	-acetyltransferase
GRF56_00145	COG0456	acetyltransferase
GRF56_00150	COG0753	catalase activity
GRF56_00175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GRF56_00180	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GRF56_00185	COG5380	lipid catabolic process
GRF56_00200	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GRF56_00205	COG4533	DNA binding
GRF56_00215	COG2873	o-acetylhomoserine
GRF56_00245	COG3842	ATPase activity
GRF56_00255	COG1175	transmembrane transport
GRF56_00285	COG3706	GGDEF domain
GRF56_00300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GRF56_00305	COG1074	ATP-dependent DNA helicase activity
GRF56_00310	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GRF56_00315	COG2259	Doxx family
GRF56_00320	COG1741	Belongs to the pirin family
GRF56_00330	COG0583	DNA-binding transcription factor activity
GRF56_00350	COG0745	RESPONSE REGULATOR receiver
GRF56_00365	COG4771	TonB-dependent receptor
GRF56_00405	COG0203	ribosomal protein L17
GRF56_00410	COG0202	RNA polymerase activity
GRF56_00415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GRF56_00420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GRF56_00425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GRF56_00430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GRF56_00435	COG0201	protein transport
GRF56_00440	COG0200	Binds to the 23S rRNA
GRF56_00445	COG1841	ribosomal large subunit assembly
GRF56_00450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GRF56_00455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GRF56_00460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GRF56_00465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GRF56_00470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GRF56_00475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GRF56_00480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GRF56_00485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GRF56_00490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GRF56_00495	COG0255	Belongs to the universal ribosomal protein uL29 family
GRF56_00500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GRF56_00505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GRF56_00510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GRF56_00515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GRF56_00520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GRF56_00525	COG0089	rRNA binding
GRF56_00530	COG0088	Forms part of the polypeptide exit tunnel
GRF56_00535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GRF56_00540	COG0051	transcription antitermination factor activity, RNA binding
GRF56_00555	COG0745	RESPONSE REGULATOR receiver
GRF56_00560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GRF56_00565	COG2183	response to ionizing radiation
GRF56_00585	COG0596	Alpha beta hydrolase
GRF56_00590	COG1040	competence protein
GRF56_00595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GRF56_00595	COG0316	Belongs to the HesB IscA family
GRF56_00600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GRF56_00605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GRF56_00610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRF56_00615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GRF56_00620	COG4942	peptidase
GRF56_00630	COG1609	Transcriptional regulator
GRF56_00645	COG0800	Aldolase
GRF56_00655	COG3265	gluconokinase activity
GRF56_00660	COG2610	gluconate transmembrane transporter activity
GRF56_00665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRF56_00670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GRF56_00680	COG0456	acetyltransferase
GRF56_00685	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GRF56_00690	COG1490	D-aminoacyl-tRNA deacylase activity
GRF56_00695	COG1295	ribonuclease BN
GRF56_00700	COG0281	malic enzyme
GRF56_00705	COG0814	amino acid
GRF56_00710	COG0702	epimerase
GRF56_00720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GRF56_00725	COG0254	rRNA binding
GRF56_00740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GRF56_00745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GRF56_00755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GRF56_00765	COG0514	ATP-dependent DNA helicase (RecQ)
GRF56_00770	COG2050	protein possibly involved in aromatic compounds catabolism
GRF56_00785	COG2258	MOSC domain
GRF56_00790	COG1177	transmembrane transport
GRF56_00795	COG1176	ABC-type spermidine putrescine transport system, permease component I
GRF56_00800	COG3842	ATPase activity
GRF56_00820	COG0174	glutamine synthetase
GRF56_00825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GRF56_00840	COG3045	CreA protein
GRF56_00845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRF56_00850	COG0443	Heat shock 70 kDa protein
GRF56_00865	COG0366	Alpha amylase catalytic
GRF56_00880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GRF56_00890	COG4211	Belongs to the binding-protein-dependent transport system permease family
GRF56_00895	COG1129	ABC transporter
GRF56_00905	COG3250	beta-galactosidase activity
GRF56_00910	COG1609	Transcriptional regulator
GRF56_00915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GRF56_00920	COG1085	galactose-1-phosphate uridylyltransferase
GRF56_00925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GRF56_00930	COG2017	converts alpha-aldose to the beta-anomer
GRF56_00935	COG1968	undecaprenyl-diphosphatase activity
GRF56_00945	COG1595	DNA-templated transcription, initiation
GRF56_00955	COG0018	arginyl-trna synthetase
GRF56_00965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GRF56_00970	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GRF56_00980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_00985	COG1131	(ABC) transporter
GRF56_00990	COG0842	Transport permease protein
GRF56_00995	COG0842	Transport permease protein
GRF56_01000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GRF56_01005	COG2146	nitrite reductase [NAD(P)H] activity
GRF56_01010	COG2116	formate transmembrane transporter activity
GRF56_01015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GRF56_01015	COG1648	precorrin-2 dehydrogenase activity
GRF56_01020	COG2239	Acts as a magnesium transporter
GRF56_01030	COG0737	Belongs to the 5'-nucleotidase family
GRF56_01065	COG0210	DNA helicase
GRF56_01070	COG0501	Belongs to the peptidase M48B family
GRF56_01125	COG1280	lysine exporter protein (LysE YggA)
GRF56_01150	COG0463	Glycosyl transferase, family 2
GRF56_01155	COG3307	-O-antigen
GRF56_01165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GRF56_01180	COG1063	alcohol dehydrogenase
GRF56_01185	COG3245	cytochrome
GRF56_01195	COG0210	DNA helicase
GRF56_01200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GRF56_01205	COG2166	iron-sulfur cluster assembly
GRF56_01210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GRF56_01240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GRF56_01250	COG0583	DNA-binding transcription factor activity
GRF56_01265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GRF56_01270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GRF56_01275	COG2223	nitrite transmembrane transporter activity
GRF56_01280	COG3279	Response regulator of the LytR AlgR family
GRF56_01285	COG3275	phosphorelay sensor kinase activity
GRF56_01290	COG2081	HI0933 family
GRF56_01295	COG1528	Iron-storage protein
GRF56_01300	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GRF56_01305	COG0589	response to stress
GRF56_01345	COG3642	lipopolysaccharide core region biosynthetic process
GRF56_01350	COG0859	PFAM glycosyl transferase family 9
GRF56_01360	COG0194	GDP metabolic process
GRF56_01365	COG1758	RNA polymerase activity
GRF56_01370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GRF56_01375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRF56_01380	COG0110	maltose O-acetyltransferase activity
GRF56_01385	COG2267	carboxylic ester hydrolase activity
GRF56_01390	COG0561	phosphatase activity
GRF56_01420	COG1309	transcriptional regulator
GRF56_01425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_01430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_01435	COG4191	Histidine kinase
GRF56_01440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRF56_01465	COG2205	protein histidine kinase activity
GRF56_01470	COG0745	RESPONSE REGULATOR receiver
GRF56_01475	COG2814	Major facilitator Superfamily
GRF56_01490	COG3977	Valine--pyruvate aminotransferase
GRF56_01495	COG0071	Belongs to the small heat shock protein (HSP20) family
GRF56_01500	COG0071	Belongs to the small heat shock protein (HSP20) family
GRF56_01515	COG0187	DNA topoisomerase II activity
GRF56_01525	COG0592	DNA-directed DNA polymerase activity
GRF56_01530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GRF56_01550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GRF56_01555	COG0594	ribonuclease P activity
GRF56_01560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GRF56_01565	COG0706	membrane insertase activity
GRF56_01570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GRF56_01575	COG4974	Belongs to the 'phage' integrase family
GRF56_01590	COG3316	Transposase and inactivated derivatives
GRF56_01625	COG3316	Transposase and inactivated derivatives
GRF56_01645	COG0840	transmembrane signaling receptor activity
GRF56_01655	COG3316	Transposase and inactivated derivatives
GRF56_01680	COG0697	spore germination
GRF56_01740	COG3550	peptidyl-serine autophosphorylation
GRF56_01750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GRF56_01755	COG1120	ATPase activity
GRF56_01760	COG4615	Cyclic peptide transporter
GRF56_01770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GRF56_01775	COG0445	tRNA wobble uridine modification
GRF56_01780	COG0357	Ribosomal RNA small subunit methyltransferase G
GRF56_01785	COG1192	Involved in chromosome partitioning
GRF56_01790	COG1475	DNA binding
GRF56_01800	COG0356	it plays a direct role in the translocation of protons across the membrane
GRF56_01810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GRF56_01815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GRF56_01820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GRF56_01825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GRF56_01830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GRF56_01835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GRF56_01840	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GRF56_01845	COG4452	Inner membrane protein CreD
GRF56_01860	COG2205	protein histidine kinase activity
GRF56_01865	COG0745	RESPONSE REGULATOR receiver
GRF56_01870	COG1349	DNA-binding transcription factor activity
GRF56_01875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GRF56_01880	COG2771	luxR family
GRF56_01890	COG0811	peptide transport
GRF56_01895	COG0811	peptide transport
GRF56_01900	COG0848	biopolymer transport protein
GRF56_01905	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GRF56_01940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GRF56_01945	COG0402	S-adenosylhomocysteine deaminase activity
GRF56_01950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GRF56_01955	COG2226	methyltransferase
GRF56_01960	COG3165	ubiquinone biosynthetic process from chorismate
GRF56_01965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GRF56_01970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GRF56_01975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GRF56_01980	COG0805	protein transport
GRF56_01985	COG0084	hydrolase, TatD family'
GRF56_02000	COG3469	chitinase activity
GRF56_02015	COG0742	ribosomal rna small subunit methyltransferase
GRF56_02025	COG0248	Ppx GppA phosphatase
GRF56_02030	COG0513	Belongs to the DEAD box helicase family
GRF56_02035	COG3118	belongs to the thioredoxin family
GRF56_02040	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GRF56_02050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GRF56_02065	COG5001	Diguanylate cyclase
GRF56_02070	COG2960	long-chain fatty acid transporting porin activity
GRF56_02085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRF56_02105	COG0559	Belongs to the binding-protein-dependent transport system permease family
GRF56_02115	COG1609	Transcriptional regulator
GRF56_02130	COG2188	Transcriptional regulator
GRF56_02135	COG0840	transmembrane signaling receptor activity
GRF56_02155	COG2202	Pas domain
GRF56_02155	COG2200	EAL domain
GRF56_02155	COG2199	diguanylate cyclase activity
GRF56_02170	COG0751	glycine-tRNA ligase activity
GRF56_02175	COG0752	glycyl-tRNA synthetase alpha subunit
GRF56_02180	COG2818	Glycosylase
GRF56_02185	COG2885	chlorophyll binding
GRF56_02190	COG0251	oxidation-reduction process
GRF56_02195	COG0425	Belongs to the sulfur carrier protein TusA family
GRF56_02210	COG2205	protein histidine kinase activity
GRF56_02215	COG0745	RESPONSE REGULATOR receiver
GRF56_02220	COG0183	Belongs to the thiolase family
GRF56_02225	COG1024	Enoyl-CoA hydratase
GRF56_02225	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRF56_02230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRF56_02235	COG0006	proline dipeptidase activity
GRF56_02240	COG1739	Uncharacterized protein family UPF0029
GRF56_02245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GRF56_02250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GRF56_02285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GRF56_02285	COG1042	CoA-binding domain protein
GRF56_02285	COG0045	succinate-CoA ligase (ADP-forming) activity
GRF56_02300	COG0583	DNA-binding transcription factor activity
GRF56_02305	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GRF56_02310	COG0166	Belongs to the GPI family
GRF56_02315	COG0668	transmembrane transport
GRF56_02320	COG1309	transcriptional regulator
GRF56_02325	COG0756	dUTP diphosphatase activity
GRF56_02330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GRF56_02335	COG2003	Belongs to the UPF0758 family
GRF56_02340	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GRF56_02345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GRF56_02355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GRF56_02360	COG2990	Protein conserved in bacteria
GRF56_02365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GRF56_02370	COG0859	PFAM glycosyl transferase family 9
GRF56_02375	COG0463	Glycosyl transferase, family 2
GRF56_02380	COG0859	PFAM glycosyl transferase family 9
GRF56_02385	COG1519	Transferase
GRF56_02400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_02405	COG1609	Transcriptional regulator
GRF56_02410	COG0604	alcohol dehydrogenase
GRF56_02440	COG3161	chorismate lyase activity
GRF56_02445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GRF56_02450	COG2937	Belongs to the GPAT DAPAT family
GRF56_02455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GRF56_02470	COG0534	Mate efflux family protein
GRF56_02475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GRF56_02480	COG2205	protein histidine kinase activity
GRF56_02485	COG0745	RESPONSE REGULATOR receiver
GRF56_02495	COG1045	serine acetyltransferase
GRF56_02505	COG3074	FtsZ-dependent cytokinesis
GRF56_02510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GRF56_02515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRF56_02515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRF56_02520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GRF56_02555	COG1609	Transcriptional regulator
GRF56_02560	COG3250	beta-galactosidase activity
GRF56_02565	COG2731	YhcH YjgK YiaL family protein
GRF56_02570	COG0531	amino acid
GRF56_02575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRF56_02580	COG0531	amino acid
GRF56_02585	COG0385	Bile acid
GRF56_02590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GRF56_02610	COG0583	DNA-binding transcription factor activity
GRF56_02615	COG1561	YicC-like family, N-terminal region
GRF56_02620	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GRF56_02625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GRF56_02640	COG2203	Gaf domain
GRF56_02640	COG3706	GGDEF domain
GRF56_02640	COG4251	negative regulation of phosphorylation
GRF56_02640	COG5001	Diguanylate cyclase
GRF56_02645	COG3084	Protein conserved in bacteria
GRF56_02655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GRF56_02660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GRF56_02670	COG1335	isochorismatase
GRF56_02680	COG1683	Conserved Protein
GRF56_02685	COG0204	Acyl-transferase
GRF56_02690	COG0204	Acyl-transferase
GRF56_02695	COG0606	chelatase, subunit chli
GRF56_02710	COG3978	acetolactate synthase activity
GRF56_02715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GRF56_02720	COG0129	dihydroxy-acid dehydratase activity
GRF56_02735	COG1309	transcriptional regulator
GRF56_02745	COG2391	methyltransferase activity
GRF56_02750	COG0840	transmembrane signaling receptor activity
GRF56_02755	COG2962	Rard protein
GRF56_02765	COG1012	belongs to the aldehyde dehydrogenase family
GRF56_02770	COG1396	sequence-specific DNA binding
GRF56_02785	COG0519	Catalyzes the synthesis of GMP from XMP
GRF56_02785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GRF56_02790	COG0583	DNA-binding transcription factor activity
GRF56_02795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRF56_02815	COG1322	Protein conserved in bacteria
GRF56_02820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GRF56_02825	COG2204	response regulator
GRF56_02830	COG3852	Histidine kinase
GRF56_02840	COG0174	glutamine synthetase
GRF56_02850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GRF56_02855	COG0569	domain protein
GRF56_02860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRF56_02860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRF56_02865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GRF56_02870	COG0242	peptide deformylase activity
GRF56_02875	COG1652	LysM domain
GRF56_02880	COG0758	DNA mediated transformation
GRF56_02885	COG2922	Belongs to the Smg family
GRF56_02890	COG0551	DNA topoisomerase type I activity
GRF56_02900	COG0009	L-threonylcarbamoyladenylate synthase
GRF56_02905	COG0408	coproporphyrinogen oxidase activity
GRF56_02910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GRF56_02920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GRF56_02930	COG3078	GTPase activator activity
GRF56_02940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GRF56_02965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GRF56_02970	COG1288	antiporter activity
GRF56_02975	COG1438	arginine binding
GRF56_02980	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GRF56_02985	COG0540	Belongs to the ATCase OTCase family
GRF56_03005	COG0583	DNA-binding transcription factor activity
GRF56_03025	COG2207	Transcriptional regulator
GRF56_03030	COG1979	alcohol dehydrogenase
GRF56_03035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GRF56_03040	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GRF56_03050	COG2964	Protein conserved in bacteria
GRF56_03055	COG3681	Belongs to the UPF0597 family
GRF56_03065	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRF56_03070	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GRF56_03075	COG0564	pseudouridine synthase activity
GRF56_03085	COG0542	response to heat
GRF56_03095	COG2502	aspartate--ammonia ligase
GRF56_03100	COG1522	sequence-specific DNA binding
GRF56_03110	COG5413	integral membrane protein
GRF56_03115	COG0516	GMP reductase activity
GRF56_03115	COG0517	IMP dehydrogenase activity
GRF56_03120	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_03135	COG2205	protein histidine kinase activity
GRF56_03145	COG2204	response regulator
GRF56_03180	COG0745	RESPONSE REGULATOR receiver
GRF56_03185	COG2205	protein histidine kinase activity
GRF56_03195	COG0243	molybdopterin cofactor binding
GRF56_03200	COG3005	denitrification pathway
GRF56_03205	COG4191	Histidine kinase
GRF56_03205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_03235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GRF56_03240	COG0569	domain protein
GRF56_03245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GRF56_03270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GRF56_03280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GRF56_03285	COG0250	Participates in transcription elongation, termination and antitermination
GRF56_03290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GRF56_03295	COG0081	regulation of translation
GRF56_03300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GRF56_03305	COG0222	ribosome binding
GRF56_03310	COG0085	RNA polymerase activity
GRF56_03315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GRF56_03320	COG2964	Protein conserved in bacteria
GRF56_03330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GRF56_03335	COG2923	Belongs to the DsrF TusC family
GRF56_03340	COG2168	tRNA wobble position uridine thiolation
GRF56_03345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GRF56_03350	COG0049	tRNA binding
GRF56_03355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GRF56_03360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GRF56_03365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GRF56_03415	COG3714	YhhN family
GRF56_03440	COG1301	dicarboxylic acid transport
GRF56_03450	COG2095	MarC family integral membrane protein
GRF56_03460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GRF56_03470	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GRF56_03475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRF56_03490	COG1770	oligopeptidase
GRF56_03505	COG4221	oxidoreductase activity
GRF56_03510	COG0583	DNA-binding transcription factor activity
GRF56_03515	COG2249	NAD(P)H dehydrogenase (quinone) activity
GRF56_03540	COG0742	ribosomal rna small subunit methyltransferase
GRF56_03545	COG0552	protein localization to endoplasmic reticulum
GRF56_03550	COG2884	Cell division ATP-binding protein ftsE
GRF56_03555	COG2177	Part of the ABC transporter FtsEX involved in
GRF56_03565	COG0288	reversible hydration of carbon dioxide
GRF56_03570	COG2188	Transcriptional regulator
GRF56_03575	COG1228	amidohydrolase
GRF56_03580	COG0010	Belongs to the arginase family
GRF56_03585	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GRF56_03590	COG2986	histidine ammonia-lyase
GRF56_03595	COG0387	Pfam Sodium calcium exchanger
GRF56_03600	COG2200	EAL domain
GRF56_03605	COG2199	diguanylate cyclase activity
GRF56_03605	COG2200	EAL domain
GRF56_03650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRF56_03655	COG1459	type II secretion system
GRF56_03675	COG4968	Prepilin-type N-terminal cleavage methylation domain
GRF56_03700	COG1077	Cell shape determining protein MreB Mrl
GRF56_03705	COG1792	Involved in formation and maintenance of cell shape
GRF56_03710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GRF56_03715	COG0424	maF-like protein
GRF56_03720	COG1530	ribonuclease E activity
GRF56_03725	COG3164	Protein of unknown function
GRF56_03735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GRF56_03740	COG0312	modulator of DNA gyrase
GRF56_03755	COG0477	Major facilitator Superfamily
GRF56_03800	COG0189	ligase activity
GRF56_03810	COG0745	RESPONSE REGULATOR receiver
GRF56_03830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GRF56_03835	COG0352	thiamine-phosphate diphosphorylase activity
GRF56_03840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GRF56_03850	COG2022	thiamine diphosphate biosynthetic process
GRF56_03855	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GRF56_03875	COG0110	maltose O-acetyltransferase activity
GRF56_03885	COG3706	GGDEF domain
GRF56_03890	COG0814	amino acid
GRF56_03895	COG0165	Argininosuccinate lyase
GRF56_03900	COG0137	argininosuccinate synthase activity
GRF56_03910	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GRF56_03915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GRF56_03925	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GRF56_03935	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GRF56_03955	COG0583	DNA-binding transcription factor activity
GRF56_03960	COG1380	Effector of murein hydrolase LrgA
GRF56_03965	COG1346	cytolysis
GRF56_03975	COG4667	esterase of the alpha-beta hydrolase superfamily
GRF56_03980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GRF56_03985	COG1546	Belongs to the CinA family
GRF56_03990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GRF56_04000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GRF56_04005	COG0527	aspartate kinase activity
GRF56_04010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GRF56_04045	COG1686	Belongs to the peptidase S11 family
GRF56_04050	COG0586	Pfam SNARE associated Golgi protein
GRF56_04055	COG1253	flavin adenine dinucleotide binding
GRF56_04065	COG0252	asparaginase activity
GRF56_04080	COG1609	Transcriptional regulator
GRF56_04085	COG1263	PTS System
GRF56_04085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_04090	COG0366	Alpha amylase catalytic
GRF56_04095	COG0110	maltose O-acetyltransferase activity
GRF56_04105	COG0564	pseudouridine synthase activity
GRF56_04110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GRF56_04135	COG0582	viral genome integration into host DNA
GRF56_04140	COG4584	PFAM Integrase catalytic
GRF56_04145	COG1484	DNA-dependent DNA replication
GRF56_04150	COG5492	domain, Protein
GRF56_04150	COG4932	domain protein
GRF56_04155	COG2200	EAL domain
GRF56_04160	COG2916	Histone family protein nucleoid-structuring protein H-NS
GRF56_04175	COG4983	Phage plasmid primase, P4 family domain protein
GRF56_04230	COG2003	Belongs to the UPF0758 family
GRF56_04270	COG2188	Transcriptional regulator
GRF56_04275	COG1397	ADP-ribosylglycohydrolase
GRF56_04285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRF56_04315	COG3012	SEC-C Motif Domain Protein
GRF56_04315	COG3318	Belongs to the UPF0149 family
GRF56_04325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GRF56_04325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GRF56_04340	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GRF56_04345	COG0038	chloride channel
GRF56_04355	COG0316	Belongs to the HesB IscA family
GRF56_04360	COG1757	Na H antiporter
GRF56_04400	COG0297	glycogen (starch) synthase activity
GRF56_04405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GRF56_04410	COG2813	Specifically methylates the guanine in position
GRF56_04415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GRF56_04430	COG1392	Phosphate transport regulator
GRF56_04435	COG0306	phosphate transporter
GRF56_04440	COG0527	aspartate kinase activity
GRF56_04440	COG0460	homoserine dehydrogenase
GRF56_04445	COG0626	cystathionine gamma-synthase activity
GRF56_04460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRF56_04465	COG0814	amino acid
GRF56_04470	COG1218	3'(2'),5'-bisphosphate nucleotidase
GRF56_04475	COG0494	nUDIX hydrolase
GRF56_04480	COG1011	Hydrolase
GRF56_04495	COG0110	maltose O-acetyltransferase activity
GRF56_04500	COG3174	membrane
GRF56_04505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GRF56_04515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GRF56_04520	COG4208	sulfate ABC transporter
GRF56_04525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GRF56_04530	COG0583	DNA-binding transcription factor activity
GRF56_04535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GRF56_04540	COG0765	amino acid transport
GRF56_04550	COG1126	abc transporter atp-binding protein
GRF56_04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_04560	COG3397	chitin binding
GRF56_04565	COG0840	transmembrane signaling receptor activity
GRF56_04580	COG0633	Ferredoxin
GRF56_04580	COG0543	2 iron, 2 sulfur cluster binding
GRF56_04605	COG1328	CTP reductase activity
GRF56_04610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GRF56_04625	COG1448	Aminotransferase
GRF56_04665	COG0513	Belongs to the DEAD box helicase family
GRF56_04675	COG3568	Endonuclease Exonuclease Phosphatase
GRF56_04695	COG3112	Uncharacterised protein family (UPF0231)
GRF56_04700	COG3835	regulator
GRF56_04705	COG2610	gluconate transmembrane transporter activity
GRF56_04710	COG1929	Belongs to the glycerate kinase type-1 family
GRF56_04725	COG0583	DNA-binding transcription factor activity
GRF56_04730	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GRF56_04740	COG1872	DUF167
GRF56_04745	COG0762	integral membrane protein
GRF56_04750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GRF56_04755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GRF56_04770	COG3022	response to hydroperoxide
GRF56_04790	COG0347	Belongs to the P(II) protein family
GRF56_04795	COG1840	ABC-type Fe3 transport system, periplasmic component
GRF56_04805	COG3842	ATPase activity
GRF56_04810	COG2837	iron assimilation
GRF56_04815	COG1438	arginine binding
GRF56_04820	COG1126	abc transporter atp-binding protein
GRF56_04825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_04830	COG4215	(ABC) transporter
GRF56_04835	COG4160	amino acid transport
GRF56_04840	COG0039	L-malate dehydrogenase activity
GRF56_04845	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GRF56_04850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GRF56_04850	COG1017	nitric oxide dioxygenase activity
GRF56_04860	COG4536	flavin adenine dinucleotide binding
GRF56_04865	COG4137	Cytochrome C assembly protein
GRF56_04870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GRF56_04875	COG0228	four-way junction DNA binding
GRF56_04880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GRF56_04885	COG0336	Belongs to the RNA methyltransferase TrmD family
GRF56_04890	COG0335	large ribosomal subunit rRNA binding
GRF56_04905	COG3066	DNA modification
GRF56_04910	COG1051	belongs to the nudix hydrolase family
GRF56_04920	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GRF56_04925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GRF56_04930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GRF56_04940	COG0583	DNA-binding transcription factor activity
GRF56_04945	COG0640	Transcriptional regulator
GRF56_04950	COG0268	Binds directly to 16S ribosomal RNA
GRF56_04955	COG0728	peptidoglycan biosynthetic process
GRF56_04960	COG0196	riboflavin kinase activity
GRF56_04965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GRF56_04970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GRF56_04975	COG1047	Peptidyl-prolyl cis-trans
GRF56_04980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GRF56_05040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GRF56_05040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GRF56_05055	COG1854	S-ribosylhomocysteine lyase activity
GRF56_05070	COG0084	hydrolase, TatD family'
GRF56_05075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GRF56_05085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GRF56_05090	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GRF56_05095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GRF56_05100	COG0813	purine-nucleoside phosphorylase activity
GRF56_05110	COG0560	Phosphoserine phosphatase
GRF56_05125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GRF56_05140	COG0776	regulation of translation
GRF56_05150	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GRF56_05155	COG1914	H( )-stimulated, divalent metal cation uptake system
GRF56_05160	COG0360	Binds together with S18 to 16S ribosomal RNA
GRF56_05165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GRF56_05170	COG0359	binds to the 23S rRNA
GRF56_05175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GRF56_05200	COG1064	alcohol dehydrogenase
GRF56_05205	COG1238	metal cluster binding
GRF56_05210	COG0612	Peptidase, M16
GRF56_05215	COG2918	glutathione biosynthetic process
GRF56_05220	COG1022	Amp-dependent synthetase and ligase
GRF56_05230	COG0456	acetyltransferase
GRF56_05250	COG0745	RESPONSE REGULATOR receiver
GRF56_05250	COG3706	GGDEF domain
GRF56_05255	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_05280	COG0477	Major facilitator Superfamily
GRF56_05285	COG0583	DNA-binding transcription factor activity
GRF56_05295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GRF56_05300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GRF56_05310	COG0673	inositol 2-dehydrogenase activity
GRF56_05320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GRF56_05325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GRF56_05330	COG3036	rescue of stalled ribosome
GRF56_05340	COG0138	bifunctional purine biosynthesis protein purh
GRF56_05345	COG0151	Belongs to the GarS family
GRF56_05365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GRF56_05370	COG0358	DNA primase activity
GRF56_05375	COG1610	YqeY-like protein
GRF56_05380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GRF56_05385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GRF56_05395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GRF56_05400	COG1027	Aspartate ammonia-lyase
GRF56_05405	COG3030	protein affecting phage T7 exclusion by the F plasmid
GRF56_05415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GRF56_05420	COG0459	protein refolding
GRF56_05470	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GRF56_05475	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GRF56_05480	COG1178	ABC-type Fe3 transport system permease component
GRF56_05485	COG4143	(ABC) transporter
GRF56_05500	COG0066	3-isopropylmalate dehydratase activity
GRF56_05505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GRF56_05510	COG0473	3-isopropylmalate dehydrogenase activity
GRF56_05515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GRF56_05525	COG0671	phosphoesterase, PA-phosphatase related
GRF56_05540	COG0028	Belongs to the TPP enzyme family
GRF56_05550	COG0440	acetolactate synthase activity
GRF56_05585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GRF56_05600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_05630	COG0745	RESPONSE REGULATOR receiver
GRF56_05635	COG3104	oligopeptide transport
GRF56_05640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GRF56_05645	COG1555	photosystem II stabilization
GRF56_05650	COG0280	phosphate acetyltransferase
GRF56_05650	COG0857	belongs to the CobB CobQ family
GRF56_05655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GRF56_05660	COG3092	negative regulation of chromosome organization
GRF56_05665	COG3013	Belongs to the UPF0304 family
GRF56_05670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GRF56_05675	COG2716	regulation of RNA biosynthetic process
GRF56_05680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GRF56_05685	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GRF56_05690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GRF56_05725	COG5002	protein histidine kinase activity
GRF56_05725	COG2198	Histidine kinase
GRF56_05725	COG0784	Response regulator, receiver
GRF56_05750	COG0840	transmembrane signaling receptor activity
GRF56_05760	COG1464	Belongs to the NlpA lipoprotein family
GRF56_05765	COG2011	ABC-type metal ion transport system permease component
GRF56_05790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GRF56_05790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GRF56_05795	COG0802	atpase or kinase
GRF56_05810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GRF56_05815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GRF56_05820	COG1923	regulation of RNA biosynthetic process
GRF56_05825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GRF56_05830	COG0330	HflC and HflK could
GRF56_05835	COG0330	HflC and HflK could
GRF56_05840	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GRF56_05845	COG0142	geranyltranstransferase activity
GRF56_05850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GRF56_05855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GRF56_05860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GRF56_05875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GRF56_05890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GRF56_05900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GRF56_05905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GRF56_05910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GRF56_05915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GRF56_05920	COG3178	'Phosphotransferase
GRF56_05925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GRF56_05930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GRF56_05935	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRF56_05945	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GRF56_05965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GRF56_05980	COG4628	conserved protein (DUF2132)
GRF56_05985	COG0688	phosphatidylethanolamine metabolic process
GRF56_05995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GRF56_06035	COG1278	Cold shock
GRF56_06045	COG0840	transmembrane signaling receptor activity
GRF56_06050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GRF56_06055	COG2252	PERMEase
GRF56_06065	COG0488	(ABC) transporter
GRF56_06080	COG0741	lytic transglycosylase activity
GRF56_06090	COG3416	Protein conserved in bacteria
GRF56_06110	COG4608	Belongs to the ABC transporter superfamily
GRF56_06115	COG0444	Belongs to the ABC transporter superfamily
GRF56_06125	COG4239	(ABC) transporter, permease
GRF56_06130	COG4174	ABC transporter (Permease)
GRF56_06135	COG4206	TonB-dependent receptor
GRF56_06145	COG0811	peptide transport
GRF56_06150	COG0811	peptide transport
GRF56_06155	COG0848	biopolymer transport protein
GRF56_06175	COG0616	signal peptide processing
GRF56_06180	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRF56_06180	COG1902	pentaerythritol trinitrate reductase activity
GRF56_06185	COG0778	Nitroreductase
GRF56_06200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRF56_06205	COG2264	protein methyltransferase activity
GRF56_06210	COG0604	alcohol dehydrogenase
GRF56_06215	COG0583	DNA-binding transcription factor activity
GRF56_06220	COG1263	PTS System
GRF56_06220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_06220	COG2190	(PTS) system
GRF56_06225	COG4145	pantothenate transmembrane transporter activity
GRF56_06235	COG0439	Biotin carboxylase
GRF56_06240	COG0511	ligase activity, forming carbon-carbon bonds
GRF56_06245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GRF56_06250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GRF56_06270	COG3381	protein complex oligomerization
GRF56_06280	COG3005	denitrification pathway
GRF56_06285	COG0745	RESPONSE REGULATOR receiver
GRF56_06295	COG1879	ABC-type sugar transport system periplasmic component
GRF56_06310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GRF56_06315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GRF56_06320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GRF56_06320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GRF56_06335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GRF56_06340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRF56_06345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GRF56_06350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GRF56_06375	COG2900	Belongs to the SlyX family
GRF56_06385	COG0545	Peptidyl-prolyl cis-trans isomerase
GRF56_06390	COG2204	response regulator
GRF56_06410	COG0737	Belongs to the 5'-nucleotidase family
GRF56_06415	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GRF56_06420	COG0142	geranyltranstransferase activity
GRF56_06425	COG1722	exodeoxyribonuclease VII activity
GRF56_06430	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GRF56_06435	COG1360	Flagellar Motor Protein
GRF56_06440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GRF56_06450	COG1534	Rna-binding protein
GRF56_06455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GRF56_06460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GRF56_06465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GRF56_06470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GRF56_06475	COG0149	triose-phosphate isomerase activity
GRF56_06480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GRF56_06495	COG0779	Required for maturation of 30S ribosomal subunits
GRF56_06500	COG0195	Participates in both transcription termination and antitermination
GRF56_06505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GRF56_06510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GRF56_06515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GRF56_06520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GRF56_06525	COG1185	polyribonucleotide nucleotidyltransferase activity
GRF56_06530	COG2201	protein-glutamate methylesterase activity
GRF56_06535	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GRF56_06545	COG0840	transmembrane signaling receptor activity
GRF56_06550	COG0835	chemotaxis
GRF56_06560	COG0643	Histidine kinase
GRF56_06560	COG2198	Histidine kinase
GRF56_06590	COG1280	lysine exporter protein (LysE YggA)
GRF56_06595	COG0826	peptidase U32
GRF56_06600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GRF56_06640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GRF56_06665	COG0300	oxidoreductase activity
GRF56_06675	COG0840	transmembrane signaling receptor activity
GRF56_06710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GRF56_06715	COG1085	galactose-1-phosphate uridylyltransferase
GRF56_06720	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GRF56_06725	COG1609	Transcriptional regulator
GRF56_06730	COG4580	involved in the transport of maltose and maltodextrins
GRF56_06755	COG2182	Extracellular solute-binding protein
GRF56_06760	COG1175	transmembrane transport
GRF56_06765	COG3833	ABC-type maltose transport systems, permease component
GRF56_06770	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GRF56_06775	COG1874	Beta-galactosidase
GRF56_06780	COG1263	PTS System
GRF56_06780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_06790	COG0469	pyruvate kinase activity
GRF56_06805	COG2003	Belongs to the UPF0758 family
GRF56_06850	COG5377	YqaJ viral recombinase family
GRF56_06880	COG1605	Chorismate mutase
GRF56_06880	COG0077	Prephenate dehydratase
GRF56_06910	COG3272	Protein of unknown function (DUF1722)
GRF56_06915	COG0789	Transcriptional regulator
GRF56_06920	COG0415	Belongs to the DNA photolyase family
GRF56_06930	COG0300	oxidoreductase activity
GRF56_06945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GRF56_06975	COG1477	protein flavinylation
GRF56_06980	COG2871	sodium ion transport
GRF56_06985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GRF56_06990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GRF56_07000	COG1805	sodium ion transport
GRF56_07005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GRF56_07010	COG0271	Belongs to the BolA IbaG family
GRF56_07015	COG2813	Specifically methylates the guanine in position
GRF56_07025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GRF56_07030	COG2211	Major facilitator Superfamily
GRF56_07035	COG3248	Nucleoside-binding outer membrane protein
GRF56_07040	COG1666	GTP binding
GRF56_07045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GRF56_07060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GRF56_07065	COG0840	transmembrane signaling receptor activity
GRF56_07070	COG0583	DNA-binding transcription factor activity
GRF56_07080	COG2363	Small membrane protein
GRF56_07085	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
GRF56_07095	COG0473	3-isopropylmalate dehydrogenase activity
GRF56_07100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GRF56_07105	COG1611	Belongs to the LOG family
GRF56_07110	COG3706	GGDEF domain
GRF56_07120	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GRF56_07120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GRF56_07130	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GRF56_07155	COG3098	single-species biofilm formation
GRF56_07160	COG0564	pseudouridine synthase activity
GRF56_07180	COG1263	PTS System
GRF56_07180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_07190	COG2171	N-acyltransferase activity
GRF56_07195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GRF56_07200	COG0024	Methionine aminopeptidase
GRF56_07205	COG0052	Belongs to the universal ribosomal protein uS2 family
GRF56_07210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GRF56_07215	COG0528	UMP kinase activity
GRF56_07220	COG0233	cytoplasmic translational termination
GRF56_07230	COG0575	Belongs to the CDS family
GRF56_07235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GRF56_07240	COG0750	zinc metalloprotease
GRF56_07255	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GRF56_07260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GRF56_07265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GRF56_07270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GRF56_07275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GRF56_07285	COG0825	malonyl-CoA metabolic process
GRF56_07295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GRF56_07300	COG1115	amino acid carrier protein
GRF56_07315	COG0714	Associated with various cellular activities
GRF56_07325	COG0583	DNA-binding transcription factor activity
GRF56_07330	COG3104	oligopeptide transport
GRF56_07335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GRF56_07340	COG1678	Uncharacterized ACR, COG1678
GRF56_07345	COG0189	ligase activity
GRF56_07350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GRF56_07360	COG3091	SprT-like family
GRF56_07370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GRF56_07390	COG0583	DNA-binding transcription factor activity
GRF56_07415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GRF56_07420	COG0739	heme binding
GRF56_07425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GRF56_07455	COG0814	amino acid
GRF56_07475	COG0531	amino acid
GRF56_07480	COG3710	Transcriptional regulator
GRF56_07485	COG0531	amino acid
GRF56_07490	COG1982	Orn Lys Arg decarboxylase major
GRF56_07495	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GRF56_07510	COG3590	peptidase
GRF56_07520	COG2199	diguanylate cyclase activity
GRF56_07520	COG2203	Gaf domain
GRF56_07555	COG0366	Alpha amylase catalytic
GRF56_07570	COG0463	Glycosyl transferase, family 2
GRF56_07585	COG2989	Protein conserved in bacteria
GRF56_07590	COG3108	Peptidase M15
GRF56_07600	COG2860	membrane
GRF56_07610	COG1196	nuclear chromosome segregation
GRF56_07615	COG3115	cell septum assembly
GRF56_07620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GRF56_07630	COG1328	CTP reductase activity
GRF56_07635	COG0602	queuosine metabolic process
GRF56_07665	COG1566	PFAM secretion protein HlyD family protein
GRF56_07670	COG1846	Transcriptional regulator
GRF56_07680	COG0281	malic enzyme
GRF56_07685	COG3290	protein histidine kinase activity
GRF56_07695	COG0697	spore germination
GRF56_07705	COG1012	belongs to the aldehyde dehydrogenase family
GRF56_07710	COG3284	Transcriptional regulator
GRF56_07715	COG0346	lactoylglutathione lyase activity
GRF56_07720	COG0745	RESPONSE REGULATOR receiver
GRF56_07725	COG5002	protein histidine kinase activity
GRF56_07735	COG4783	chaperone-mediated protein folding
GRF56_07750	COG3142	Participates in the control of copper homeostasis
GRF56_07755	COG0545	Peptidyl-prolyl cis-trans isomerase
GRF56_07780	COG0678	peroxiredoxin activity
GRF56_07790	COG0019	diaminopimelate decarboxylase activity
GRF56_07795	COG1115	amino acid carrier protein
GRF56_07805	COG0095	Lipoate-protein ligase
GRF56_07810	COG2233	PERMEase
GRF56_07815	COG3706	GGDEF domain
GRF56_07825	COG0534	Mate efflux family protein
GRF56_07835	COG0281	malic enzyme
GRF56_07865	COG0531	amino acid
GRF56_07870	COG1752	Esterase of the alpha-beta hydrolase superfamily
GRF56_07875	COG3706	GGDEF domain
GRF56_07880	COG1566	PFAM secretion protein HlyD family protein
GRF56_07890	COG1032	radical SAM domain protein
GRF56_07935	COG0583	DNA-binding transcription factor activity
GRF56_07945	COG0673	inositol 2-dehydrogenase activity
GRF56_07950	COG2920	part of a sulfur-relay system
GRF56_07955	COG1289	transmembrane transporter activity
GRF56_07960	COG0670	Belongs to the BI1 family
GRF56_07975	COG3623	hexulose-6-phosphate isomerase
GRF56_07980	COG0561	phosphatase activity
GRF56_08005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GRF56_08015	COG1486	melibiose metabolic process
GRF56_08020	COG2169	Transcriptional regulator
GRF56_08020	COG1917	Cupin 2, conserved barrel domain protein
GRF56_08025	COG1447	Phosphotransferase system cellobiose-specific component IIA
GRF56_08030	COG2723	6-phospho-beta-galactosidase activity
GRF56_08035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GRF56_08040	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GRF56_08050	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GRF56_08060	COG3156	type II secretion system protein K
GRF56_08065	COG4795	General secretion pathway protein
GRF56_08070	COG2165	general secretion pathway protein
GRF56_08080	COG2165	general secretion pathway protein
GRF56_08085	COG1459	type II secretion system
GRF56_08090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRF56_08100	COG3031	protein transport across the cell outer membrane
GRF56_08110	COG3267	Type II secretory pathway component ExeA
GRF56_08110	COG3409	Peptidoglycan-binding domain 1 protein
GRF56_08115	COG3437	response regulator, receiver
GRF56_08115	COG2770	Histidine kinase
GRF56_08130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GRF56_08135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GRF56_08140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_08150	COG2190	(PTS) system
GRF56_08155	COG3706	GGDEF domain
GRF56_08160	COG3590	peptidase
GRF56_08175	COG3264	Mechanosensitive ion channel
GRF56_08175	COG1196	nuclear chromosome segregation
GRF56_08180	COG0469	pyruvate kinase activity
GRF56_08190	COG3384	dioxygenase
GRF56_08210	COG0419	ATPase involved in DNA repair
GRF56_08215	COG0420	3'-5' exonuclease activity
GRF56_08225	COG2974	May be involved in recombination
GRF56_08230	COG0405	Gamma-glutamyltransferase
GRF56_08240	COG1283	sodium-dependent phosphate transmembrane transporter activity
GRF56_08250	COG0531	amino acid
GRF56_08260	COG0531	amino acid
GRF56_08275	COG1396	sequence-specific DNA binding
GRF56_08275	COG1917	Cupin 2, conserved barrel domain protein
GRF56_08280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRF56_08310	COG0745	RESPONSE REGULATOR receiver
GRF56_08320	COG3038	cytochrome b561
GRF56_08325	COG1720	tRNA m6t6A37 methyltransferase activity
GRF56_08345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GRF56_08350	COG4988	ABC transporter
GRF56_08370	COG0745	RESPONSE REGULATOR receiver
GRF56_08380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GRF56_08410	COG0798	PFAM Bile acid sodium symporter
GRF56_08415	COG1393	Belongs to the ArsC family
GRF56_08420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GRF56_08440	COG1988	membrane-bound metal-dependent
GRF56_08455	COG0159	tryptophan synthase activity
GRF56_08460	COG0133	tryptophan synthase activity
GRF56_08465	COG0135	phosphoribosylanthranilate isomerase activity
GRF56_08465	COG0134	indole-3-glycerol-phosphate synthase activity
GRF56_08470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GRF56_08475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GRF56_08475	COG0512	Glutamine amidotransferase of anthranilate synthase
GRF56_08480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GRF56_08490	COG0009	L-threonylcarbamoyladenylate synthase
GRF56_08500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GRF56_08510	COG1946	Acyl-CoA thioesterase
GRF56_08515	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
GRF56_08520	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GRF56_08535	COG0083	homoserine kinase activity
GRF56_08540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GRF56_08545	COG1196	nuclear chromosome segregation
GRF56_08560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GRF56_08575	COG2916	Histone family protein nucleoid-structuring protein H-NS
GRF56_08605	COG2197	response regulator
GRF56_08610	COG3447	MASE1 domain protein
GRF56_08610	COG5001	Diguanylate cyclase
GRF56_08610	COG5002	protein histidine kinase activity
GRF56_08620	COG0840	transmembrane signaling receptor activity
GRF56_08635	COG2855	membrane
GRF56_08645	COG2197	response regulator
GRF56_08650	COG3604	Transcriptional regulator
GRF56_08655	COG0426	domain, Protein
GRF56_08655	COG1773	rubredoxin
GRF56_08660	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRF56_08675	COG2197	response regulator
GRF56_08685	COG2223	nitrite transmembrane transporter activity
GRF56_08690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GRF56_08695	COG1140	nitrate reductase beta subunit
GRF56_08700	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GRF56_08705	COG2181	nitrate reductase activity
GRF56_08730	COG0745	RESPONSE REGULATOR receiver
GRF56_08730	COG3706	GGDEF domain
GRF56_08785	COG1342	Belongs to the UPF0251 family
GRF56_08800	COG1309	transcriptional regulator
GRF56_08805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_08810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_08820	COG1091	dTDP-4-dehydrorhamnose reductase activity
GRF56_08840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GRF56_08865	COG1216	Glycosyl transferase, family 2
GRF56_08875	COG1132	(ABC) transporter
GRF56_08895	COG0438	transferase activity, transferring glycosyl groups
GRF56_08945	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GRF56_08950	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
GRF56_08965	COG1538	Outer membrane efflux protein
GRF56_08970	COG1136	(ABC) transporter
GRF56_08970	COG0577	efflux transmembrane transporter activity
GRF56_08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_08980	COG1227	inorganic diphosphatase activity
GRF56_08985	COG0497	DNA recombination
GRF56_08990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GRF56_08995	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GRF56_09000	COG0443	Heat shock 70 kDa protein
GRF56_09005	COG0484	heat shock protein binding
GRF56_09035	COG1285	pathogenesis
GRF56_09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRF56_09065	COG2391	methyltransferase activity
GRF56_09085	COG1136	(ABC) transporter
GRF56_09085	COG0577	efflux transmembrane transporter activity
GRF56_09090	COG1136	(ABC) transporter
GRF56_09090	COG0577	efflux transmembrane transporter activity
GRF56_09095	COG0577	efflux transmembrane transporter activity
GRF56_09095	COG1136	(ABC) transporter
GRF56_09105	COG0095	Lipoate-protein ligase
GRF56_09115	COG0702	epimerase
GRF56_09120	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GRF56_09125	COG1454	alcohol dehydrogenase
GRF56_09135	COG0564	pseudouridine synthase activity
GRF56_09165	COG1280	lysine exporter protein (LysE YggA)
GRF56_09180	COG3263	regulation of cellular component size
GRF56_09190	COG1876	peptidase activity
GRF56_09195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GRF56_09200	COG1393	Belongs to the ArsC family
GRF56_09210	COG3069	C4-dicarboxylate transmembrane transporter activity
GRF56_09215	COG1473	amidohydrolase
GRF56_09225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GRF56_09235	COG0017	Asparaginyl-tRNA synthetase
GRF56_09250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GRF56_09255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GRF56_09260	COG0156	8-amino-7-oxononanoate synthase activity
GRF56_09265	COG2226	methyltransferase
GRF56_09265	COG1073	alpha beta
GRF56_09270	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GRF56_09275	COG0501	Belongs to the peptidase M48B family
GRF56_09285	COG3217	Mosc domain protein beta barrel domain protein
GRF56_09285	COG0633	Ferredoxin
GRF56_09285	COG3217	Mosc domain protein beta barrel domain protein
GRF56_09285	COG0633	Ferredoxin
GRF56_09300	COG0674	pyruvate-flavodoxin oxidoreductase activity
GRF56_09300	COG1013	pyruvate-flavodoxin oxidoreductase activity
GRF56_09300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GRF56_09300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GRF56_09310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GRF56_09315	COG1607	acyl-coa hydrolase
GRF56_09325	COG3021	interspecies interaction between organisms
GRF56_09330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GRF56_09335	COG2027	D-alanyl-D-alanine carboxypeptidase
GRF56_09340	COG1061	Type III restriction enzyme res subunit
GRF56_09345	COG1566	PFAM secretion protein HlyD family protein
GRF56_09355	COG1966	Carbon starvation protein
GRF56_09360	COG3279	Response regulator of the LytR AlgR family
GRF56_09365	COG3275	phosphorelay sensor kinase activity
GRF56_09370	COG2199	diguanylate cyclase activity
GRF56_09370	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRF56_09375	COG2194	sulfuric ester hydrolase activity
GRF56_09380	COG1846	Transcriptional regulator
GRF56_09380	COG1940	carbohydrate kinase activity
GRF56_09385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GRF56_09390	COG0363	glucosamine-6-phosphate deaminase activity
GRF56_09395	COG1263	PTS System
GRF56_09395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_09395	COG2190	(PTS) system
GRF56_09405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GRF56_09410	COG0735	belongs to the Fur family
GRF56_09420	COG0716	FMN binding
GRF56_09435	COG0596	Alpha beta hydrolase
GRF56_09440	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GRF56_09445	COG0033	Phosphoglucomutase
GRF56_09455	COG1846	Transcriptional regulator
GRF56_09460	COG2951	lytic endotransglycosylase activity
GRF56_09465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GRF56_09470	COG4136	ATPase activity
GRF56_09480	COG4134	Bacterial extracellular solute-binding protein
GRF56_09490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GRF56_09500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GRF56_09510	COG0729	surface antigen
GRF56_09515	COG2911	Protein conserved in bacteria
GRF56_09535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GRF56_09545	COG0741	lytic transglycosylase activity
GRF56_09555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GRF56_09560	COG4771	TonB-dependent receptor
GRF56_09565	COG1169	isochorismate synthase
GRF56_09570	COG1021	2,3-dihydroxybenzoate-AMP ligase
GRF56_09575	COG1535	isochorismatase
GRF56_09575	COG3433	isochorismatase activity
GRF56_09580	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_09585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GRF56_09585	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GRF56_09610	COG1278	Cold shock
GRF56_09635	COG4166	transmembrane transport
GRF56_09640	COG1349	DNA-binding transcription factor activity
GRF56_09650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GRF56_09655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GRF56_09665	COG0784	Response regulator, receiver
GRF56_09665	COG3437	response regulator, receiver
GRF56_09670	COG1187	pseudouridine synthase activity
GRF56_09680	COG4166	transmembrane transport
GRF56_09685	COG0622	Phosphoesterase
GRF56_09700	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GRF56_09705	COG0835	chemotaxis
GRF56_09705	COG0784	Response regulator, receiver
GRF56_09710	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GRF56_09715	COG1815	bacterial-type flagellum-dependent cell motility
GRF56_09720	COG1558	bacterial-type flagellum-dependent cell motility
GRF56_09725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GRF56_09735	COG4787	bacterial-type flagellum-dependent cell motility
GRF56_09740	COG4786	Flagellar basal body rod
GRF56_09745	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GRF56_09750	COG1706	bacterial-type flagellum-dependent cell motility
GRF56_09755	COG3951	Flagellar rod assembly protein muramidase FlgJ
GRF56_09755	COG1705	Flagellar rod assembly protein muramidase FlgJ
GRF56_09765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRF56_09770	COG2239	Acts as a magnesium transporter
GRF56_09775	COG0248	Ppx GppA phosphatase
GRF56_09780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GRF56_09785	COG2716	regulation of RNA biosynthetic process
GRF56_09795	COG2204	response regulator
GRF56_09800	COG3852	Histidine kinase
GRF56_09805	COG2204	response regulator
GRF56_09810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GRF56_09815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GRF56_09820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GRF56_09825	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GRF56_09845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GRF56_09855	COG0590	tRNA wobble adenosine to inosine editing
GRF56_09860	COG0573	inorganic phosphate transmembrane transporter activity
GRF56_09865	COG0581	inorganic phosphate transmembrane transporter activity
GRF56_09875	COG0704	Plays a role in the regulation of phosphate uptake
GRF56_09880	COG1253	flavin adenine dinucleotide binding
GRF56_09895	COG0531	amino acid
GRF56_09910	COG1126	abc transporter atp-binding protein
GRF56_09915	COG0765	amino acid transport
GRF56_09920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_09925	COG3706	GGDEF domain
GRF56_09930	COG2271	Major facilitator Superfamily
GRF56_09940	COG2197	response regulator
GRF56_09945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GRF56_09965	COG1785	Belongs to the alkaline phosphatase family
GRF56_09970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GRF56_09975	COG0123	including yeast histone deacetylase and acetoin utilization protein
GRF56_09985	COG1199	ATP-dependent helicase activity
GRF56_09995	COG0287	Prephenate dehydrogenase
GRF56_09995	COG1605	Chorismate mutase
GRF56_10000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GRF56_10010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRF56_10015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRF56_10050	COG0537	adenosine 5'-monophosphoramidase activity
GRF56_10065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GRF56_10080	COG1301	dicarboxylic acid transport
GRF56_10085	COG0840	transmembrane signaling receptor activity
GRF56_10095	COG2354	Protein conserved in bacteria
GRF56_10105	COG2233	PERMEase
GRF56_10115	COG1252	NADH dehydrogenase
GRF56_10125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GRF56_10135	COG0446	pyridine nucleotide-disulphide oxidoreductase
GRF56_10145	COG2373	Large extracellular alpha-helical protein
GRF56_10150	COG4953	penicillin-binding protein 1C
GRF56_10190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GRF56_10220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GRF56_10220	COG0301	tRNA thio-modification
GRF56_10240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRF56_10295	COG4310	Domain of unknown function (DUF2172)
GRF56_10310	COG2089	acid synthase
GRF56_10320	COG1083	cytidylyl-transferase
GRF56_10335	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_10340	COG0318	PFAM AMP-dependent synthetase and ligase
GRF56_10355	COG1215	transferase activity, transferring glycosyl groups
GRF56_10360	COG0562	UDP-galactopyranose mutase
GRF56_10365	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GRF56_10410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GRF56_10415	COG1086	Polysaccharide biosynthesis protein
GRF56_10430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GRF56_10450	COG0483	inositol monophosphate 1-phosphatase activity
GRF56_10460	COG0625	glutathione transferase activity
GRF56_10465	COG2814	Major facilitator Superfamily
GRF56_10470	COG0583	DNA-binding transcription factor activity
GRF56_10475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GRF56_10480	COG0243	molybdopterin cofactor binding
GRF56_10490	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GRF56_10500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GRF56_10505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GRF56_10510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GRF56_10515	COG0509	glycine decarboxylation via glycine cleavage system
GRF56_10520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GRF56_10520	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GRF56_10550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GRF56_10610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GRF56_10620	COG0840	transmembrane signaling receptor activity
GRF56_10650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GRF56_10655	COG0574	Belongs to the PEP-utilizing enzyme family
GRF56_10655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GRF56_10670	COG1464	Belongs to the NlpA lipoprotein family
GRF56_10675	COG3083	sulfuric ester hydrolase activity
GRF56_10680	COG3082	Protein of unknown function (DUF1414)
GRF56_10685	COG3081	Nucleoid-associated protein
GRF56_10695	COG1175	transmembrane transport
GRF56_10705	COG3842	ATPase activity
GRF56_10730	COG0425	Belongs to the sulfur carrier protein TusA family
GRF56_10735	COG4783	chaperone-mediated protein folding
GRF56_10745	COG1393	Belongs to the ArsC family
GRF56_10755	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GRF56_10760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_10765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GRF56_10770	COG2431	L-lysine efflux transmembrane transporter activity
GRF56_10780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_10785	COG4215	(ABC) transporter
GRF56_10790	COG4160	amino acid transport
GRF56_10805	COG0564	pseudouridine synthase activity
GRF56_10820	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GRF56_10830	COG0625	glutathione transferase activity
GRF56_10840	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRF56_10845	COG3069	C4-dicarboxylate transmembrane transporter activity
GRF56_10855	COG0367	asparagine synthase
GRF56_10865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GRF56_10865	COG4651	solute:proton antiporter activity
GRF56_10870	COG0647	UMP catabolic process
GRF56_10875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GRF56_10885	COG1902	pentaerythritol trinitrate reductase activity
GRF56_10890	COG1253	flavin adenine dinucleotide binding
GRF56_10900	COG0277	FAD linked oxidase domain protein
GRF56_10900	COG0247	lactate metabolic process
GRF56_10910	COG2050	protein possibly involved in aromatic compounds catabolism
GRF56_10915	COG0513	Belongs to the DEAD box helicase family
GRF56_10925	COG5001	Diguanylate cyclase
GRF56_10925	COG3300	MHYT domain
GRF56_10930	COG2056	Na+-H+ antiporter family
GRF56_10935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GRF56_10940	COG0671	phosphoesterase, PA-phosphatase related
GRF56_10945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GRF56_10950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GRF56_10960	COG0101	tRNA pseudouridine synthase activity
GRF56_10965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GRF56_10970	COG0285	dihydrofolate synthase activity
GRF56_10975	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GRF56_10980	COG0393	Putative heavy-metal-binding
GRF56_10990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GRF56_10990	COG1648	precorrin-2 dehydrogenase activity
GRF56_10995	COG2221	Nitrite and sulphite reductase 4Fe-4S
GRF56_11010	COG4667	esterase of the alpha-beta hydrolase superfamily
GRF56_11015	COG1619	proteins homologs of microcin C7 resistance protein MccF
GRF56_11020	COG1368	sulfuric ester hydrolase activity
GRF56_11030	COG0527	aspartate kinase activity
GRF56_11035	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GRF56_11035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GRF56_11040	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GRF56_11060	COG0596	Alpha beta hydrolase
GRF56_11075	COG1285	pathogenesis
GRF56_11090	COG1136	(ABC) transporter
GRF56_11105	COG2814	Major facilitator Superfamily
GRF56_11125	COG0672	)-iron permease
GRF56_11160	COG0659	secondary active sulfate transmembrane transporter activity
GRF56_11175	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GRF56_11175	COG0392	lysyltransferase activity
GRF56_11185	COG2205	protein histidine kinase activity
GRF56_11190	COG0745	RESPONSE REGULATOR receiver
GRF56_11210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GRF56_11215	COG1278	Cold shock
GRF56_11220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GRF56_11225	COG0542	response to heat
GRF56_11230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GRF56_11235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GRF56_11240	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GRF56_11245	COG3134	Outer membrane lipoprotein
GRF56_11250	COG3706	GGDEF domain
GRF56_11255	COG0492	ferredoxin-NADP+ reductase activity
GRF56_11260	COG0686	Belongs to the AlaDH PNT family
GRF56_11270	COG1674	ftsk spoiiie
GRF56_11270	COG0531	amino acid
GRF56_11275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GRF56_11280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GRF56_11285	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GRF56_11290	COG1286	toxin biosynthetic process
GRF56_11295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GRF56_11305	COG0563	adenylate kinase activity
GRF56_11310	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GRF56_11320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRF56_11335	COG3300	MHYT domain
GRF56_11335	COG5001	Diguanylate cyclase
GRF56_11365	COG0598	Magnesium transport protein CorA
GRF56_11385	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GRF56_11390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GRF56_11395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GRF56_11410	COG0513	Belongs to the DEAD box helicase family
GRF56_11415	COG0386	Belongs to the glutathione peroxidase family
GRF56_11425	COG1181	Belongs to the D-alanine--D-alanine ligase family
GRF56_11430	COG0383	alpha-mannosidase activity
GRF56_11435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_11435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_11435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_11440	COG2188	Transcriptional regulator
GRF56_11445	COG1570	exodeoxyribonuclease VII activity
GRF56_11450	COG3038	cytochrome b561
GRF56_11455	COG0516	GMP reductase activity
GRF56_11455	COG0517	IMP dehydrogenase activity
GRF56_11460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GRF56_11460	COG0519	Catalyzes the synthesis of GMP from XMP
GRF56_11475	COG5001	Diguanylate cyclase
GRF56_11475	COG4251	negative regulation of phosphorylation
GRF56_11475	COG3706	GGDEF domain
GRF56_11475	COG2203	Gaf domain
GRF56_11480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRF56_11485	COG3437	response regulator, receiver
GRF56_11500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
GRF56_11505	COG0437	4 iron, 4 sulfur cluster binding
GRF56_11510	COG5557	Pfam Polysulphide reductase, NrfD
GRF56_11515	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
GRF56_11520	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GRF56_11525	COG1773	rubredoxin
GRF56_11535	COG0601	transmembrane transport
GRF56_11540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRF56_11545	COG0444	Belongs to the ABC transporter superfamily
GRF56_11550	COG1124	(ABC) transporter
GRF56_11555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GRF56_11560	COG0375	protein maturation
GRF56_11565	COG0309	Hydrogenase expression formation protein (HypE)
GRF56_11575	COG0298	carbon dioxide binding
GRF56_11580	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
GRF56_11590	COG1921	L-seryl-tRNASec selenium transferase activity
GRF56_11600	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GRF56_11610	COG3260	NADH ubiquinone oxidoreductase 20
GRF56_11615	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_11620	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
GRF56_11620	COG3261	NADH dehydrogenase
GRF56_11625	COG0650	Formate hydrogenlyase subunit 4
GRF56_11630	COG0651	ATP synthesis coupled electron transport
GRF56_11635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GRF56_11640	COG3158	transport of potassium into the cell
GRF56_11645	COG1196	nuclear chromosome segregation
GRF56_11650	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GRF56_11675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GRF56_11685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRF56_11690	COG3046	protein related to deoxyribodipyrimidine photolyase
GRF56_11700	COG3033	Beta-eliminating lyase
GRF56_11705	COG0295	cytidine deaminase activity
GRF56_11710	COG1346	cytolysis
GRF56_11715	COG1380	Effector of murein hydrolase LrgA
GRF56_11720	COG3345	alpha-galactosidase
GRF56_11730	COG2925	Exonuclease
GRF56_11735	COG0582	viral genome integration into host DNA
GRF56_11790	COG1846	Transcriptional regulator
GRF56_11930	COG0464	growth
GRF56_11965	COG1802	Transcriptional regulator
GRF56_11965	COG4626	Terminase
GRF56_11980	COG0616	signal peptide processing
GRF56_12070	COG0641	radical SAM
GRF56_12095	COG2304	oxidoreductase activity
GRF56_12100	COG2304	oxidoreductase activity
GRF56_12115	COG0714	Associated with various cellular activities
GRF56_12120	COG3119	arylsulfatase activity
GRF56_12125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRF56_12135	COG1643	Atp-dependent helicase
GRF56_12145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GRF56_12155	COG0183	Belongs to the thiolase family
GRF56_12160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GRF56_12165	COG2067	long-chain fatty acid transport protein
GRF56_12170	COG2067	long-chain fatty acid transport protein
GRF56_12180	COG1595	DNA-templated transcription, initiation
GRF56_12190	COG2304	oxidoreductase activity
GRF56_12210	COG0714	Associated with various cellular activities
GRF56_12215	COG0183	Belongs to the thiolase family
GRF56_12220	COG1250	3-hydroxyacyl-CoA dehydrogenase
GRF56_12220	COG1024	Enoyl-CoA hydratase
GRF56_12225	COG2719	SpoVR family
GRF56_12230	COG2718	Belongs to the UPF0229 family
GRF56_12235	COG2766	serine protein kinase
GRF56_12240	COG0514	ATP-dependent DNA helicase (RecQ)
GRF56_12245	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GRF56_12255	COG0814	amino acid
GRF56_12260	COG0494	nUDIX hydrolase
GRF56_12275	COG2824	Alkylphosphonate utilization operon protein PhnA
GRF56_12290	COG0406	alpha-ribazole phosphatase activity
GRF56_12295	COG3706	GGDEF domain
GRF56_12300	COG2840	Smr protein MutS2
GRF56_12305	COG2890	protein-(glutamine-N5) methyltransferase activity
GRF56_12310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GRF56_12320	COG0513	Belongs to the DEAD box helicase family
GRF56_12330	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GRF56_12340	COG0814	amino acid
GRF56_12345	COG1609	Transcriptional regulator
GRF56_12350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_12350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_12355	COG1105	Belongs to the carbohydrate kinase PfkB family
GRF56_12360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GRF56_12360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_12360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_12365	COG3313	Fe-S protein
GRF56_12370	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GRF56_12375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GRF56_12380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRF56_12385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GRF56_12395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GRF56_12405	COG0366	Alpha amylase catalytic
GRF56_12420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GRF56_12425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GRF56_12430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GRF56_12435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GRF56_12440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GRF56_12445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRF56_12445	COG0072	phenylalanine-tRNA ligase activity
GRF56_12450	COG0776	regulation of translation
GRF56_12455	COG0784	Response regulator, receiver
GRF56_12455	COG2205	protein histidine kinase activity
GRF56_12470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GRF56_12480	COG2199	diguanylate cyclase activity
GRF56_12485	COG1609	Transcriptional regulator
GRF56_12490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRF56_12495	COG1879	ABC-type sugar transport system periplasmic component
GRF56_12500	COG1172	Belongs to the binding-protein-dependent transport system permease family
GRF56_12505	COG1129	ABC transporter
GRF56_12510	COG1869	D-ribose catabolic process
GRF56_12515	COG0625	glutathione transferase activity
GRF56_12525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GRF56_12530	COG1177	transmembrane transport
GRF56_12535	COG1176	ABC-type spermidine putrescine transport system, permease component I
GRF56_12555	COG0037	tRNA processing
GRF56_12560	COG0589	response to stress
GRF56_12565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GRF56_12580	COG2217	Heavy metal translocating P-type atpase
GRF56_12590	COG2010	Cytochrome c
GRF56_12605	COG3278	Belongs to the heme-copper respiratory oxidase family
GRF56_12615	COG1956	GAF domain-containing protein
GRF56_12620	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GRF56_12630	COG0308	aminopeptidase N
GRF56_12640	COG2902	Dehydrogenase
GRF56_12645	COG0167	dihydroorotate dehydrogenase activity
GRF56_12660	COG0254	rRNA binding
GRF56_12665	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GRF56_12670	COG0116	Belongs to the methyltransferase superfamily
GRF56_12670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GRF56_12690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GRF56_12695	COG1067	ATP-dependent peptidase activity
GRF56_12725	COG3141	response to X-ray
GRF56_12730	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GRF56_12735	COG4221	oxidoreductase activity
GRF56_12780	COG0372	Belongs to the citrate synthase family
GRF56_12785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GRF56_12790	COG2995	paraquat-inducible protein a
GRF56_12795	COG2995	paraquat-inducible protein a
GRF56_12800	COG3008	intermembrane lipid transfer
GRF56_12805	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GRF56_12805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRF56_12820	COG0084	hydrolase, TatD family'
GRF56_12825	COG0470	DNA polymerase III
GRF56_12830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GRF56_12835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GRF56_12840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GRF56_12845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GRF56_12850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GRF56_12855	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_12865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GRF56_12870	COG0416	fatty acid biosynthetic process
GRF56_12875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GRF56_12880	COG1399	metal-binding, possibly nucleic acid-binding protein
GRF56_12885	COG0424	maF-like protein
GRF56_12900	COG1530	ribonuclease E activity
GRF56_12910	COG0306	phosphate transporter
GRF56_12915	COG0717	Belongs to the dCTP deaminase family
GRF56_12920	COG0572	uridine kinase
GRF56_12925	COG0489	protein tyrosine kinase activity
GRF56_12930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRF56_12930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GRF56_12940	COG1254	Belongs to the acylphosphatase family
GRF56_12945	COG0840	transmembrane signaling receptor activity
GRF56_12950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GRF56_12965	COG0709	Synthesizes selenophosphate from selenide and ATP
GRF56_12970	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
GRF56_12975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRF56_12985	COG0318	PFAM AMP-dependent synthetase and ligase
GRF56_12990	COG2267	carboxylic ester hydrolase activity
GRF56_13000	COG1214	PFAM Peptidase M22, glycoprotease
GRF56_13005	COG1199	ATP-dependent helicase activity
GRF56_13015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GRF56_13020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GRF56_13025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GRF56_13030	COG0131	Imidazoleglycerol-phosphate dehydratase
GRF56_13030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GRF56_13035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GRF56_13040	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GRF56_13045	COG0107	imidazoleglycerol-phosphate synthase activity
GRF56_13060	COG3706	GGDEF domain
GRF56_13065	COG0318	PFAM AMP-dependent synthetase and ligase
GRF56_13070	COG1288	antiporter activity
GRF56_13080	COG3134	Outer membrane lipoprotein
GRF56_13085	COG2080	2 iron, 2 sulfur cluster binding
GRF56_13090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GRF56_13095	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GRF56_13100	COG2252	PERMEase
GRF56_13105	COG0402	S-adenosylhomocysteine deaminase activity
GRF56_13110	COG2233	PERMEase
GRF56_13115	COG2080	2 iron, 2 sulfur cluster binding
GRF56_13115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GRF56_13120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GRF56_13125	COG0402	S-adenosylhomocysteine deaminase activity
GRF56_13130	COG0493	'glutamate synthase
GRF56_13130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GRF56_13140	COG2068	MobA-Related Protein
GRF56_13145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GRF56_13150	COG3608	succinylglutamate desuccinylase aspartoacylase
GRF56_13150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GRF56_13155	COG0697	spore germination
GRF56_13160	COG0549	Belongs to the carbamate kinase family
GRF56_13170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GRF56_13175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GRF56_13180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GRF56_13215	COG0242	peptide deformylase activity
GRF56_13230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GRF56_13235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GRF56_13240	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GRF56_13250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GRF56_13255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GRF56_13265	COG0205	6-phosphofructokinase activity
GRF56_13275	COG3123	guanosine phosphorylase activity
GRF56_13280	COG1760	l-serine dehydratase
GRF56_13285	COG1760	l-serine dehydratase
GRF56_13290	COG3100	YcgL domain-containing protein
GRF56_13295	COG0850	regulation of cytokinetic process
GRF56_13300	COG2894	cell division
GRF56_13305	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GRF56_13315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRF56_13355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GRF56_13360	COG0697	spore germination
GRF56_13365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GRF56_13370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRF56_13380	COG0307	riboflavin synthase, alpha
GRF56_13395	COG0534	Mate efflux family protein
GRF56_13440	COG4681	YaeQ
GRF56_13455	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GRF56_13460	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GRF56_13465	COG0586	Pfam SNARE associated Golgi protein
GRF56_13475	COG0556	nucleotide-excision repair
GRF56_13490	COG0569	domain protein
GRF56_13490	COG2985	domain, Protein
GRF56_13495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GRF56_13500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GRF56_13500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRF56_13515	COG3069	C4-dicarboxylate transmembrane transporter activity
GRF56_13530	COG1451	nucleotide metabolic process
GRF56_13545	COG0417	DNA replication proofreading
GRF56_13555	COG2203	Gaf domain
GRF56_13555	COG2199	diguanylate cyclase activity
GRF56_13570	COG1560	Kdo2-lipid A biosynthetic process
GRF56_13575	COG1560	Kdo2-lipid A biosynthetic process
GRF56_13590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GRF56_13595	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GRF56_13600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GRF56_13605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GRF56_13610	COG2832	Protein of unknown function (DUF454)
GRF56_13615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GRF56_13630	COG1011	Hydrolase
GRF56_13635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GRF56_13685	COG3593	DNA synthesis involved in DNA repair
GRF56_13700	COG0583	DNA-binding transcription factor activity
GRF56_13705	COG0730	response to heat
GRF56_13715	COG1846	Transcriptional regulator
GRF56_13715	COG1940	carbohydrate kinase activity
GRF56_13720	COG0840	transmembrane signaling receptor activity
GRF56_13725	COG3012	SEC-C Motif Domain Protein
GRF56_13730	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GRF56_13735	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GRF56_13740	COG0247	lactate metabolic process
GRF56_13750	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GRF56_13755	COG0437	4 iron, 4 sulfur cluster binding
GRF56_13760	COG3301	Polysulphide reductase, NrfD
GRF56_13765	COG1138	Cytochrome C-type biogenesis protein
GRF56_13775	COG4235	cytochrome complex assembly
GRF56_13775	COG3088	subunit of a heme lyase
GRF56_13790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRF56_13800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GRF56_13810	COG1840	ABC-type Fe3 transport system, periplasmic component
GRF56_13815	COG3842	ATPase activity
GRF56_13825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRF56_13845	COG0045	succinate-CoA ligase (ADP-forming) activity
GRF56_13850	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRF56_13855	COG0567	Dehydrogenase, E1 component
GRF56_13865	COG1053	succinate dehydrogenase
GRF56_13870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GRF56_13875	COG2009	succinate dehydrogenase
GRF56_13925	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GRF56_13940	COG2501	S4 domain
GRF56_13950	COG1132	(ABC) transporter
GRF56_13955	COG1132	(ABC) transporter
GRF56_13965	COG3118	belongs to the thioredoxin family
GRF56_13970	COG0471	metal ion transport
GRF56_13975	COG0058	SHG alpha-glucan phosphorylase activity
GRF56_13990	COG0697	spore germination
GRF56_14000	COG2062	phosphohistidine phosphatase, SixA
GRF56_14005	COG1025	Belongs to the peptidase M16 family
GRF56_14050	COG0730	response to heat
GRF56_14060	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_14070	COG1024	Enoyl-CoA hydratase
GRF56_14075	COG1024	Enoyl-CoA hydratase
GRF56_14080	COG1960	acyl-CoA dehydrogenase activity
GRF56_14085	COG1960	acyl-CoA dehydrogenase activity
GRF56_14090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GRF56_14095	COG1024	Enoyl-CoA hydratase
GRF56_14125	COG1584	GPR1 FUN34 yaaH family protein
GRF56_14140	COG1115	amino acid carrier protein
GRF56_14145	COG1024	Enoyl-CoA hydratase
GRF56_14160	COG3162	membrane
GRF56_14165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GRF56_14170	COG0488	(ABC) transporter
GRF56_14175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GRF56_14180	COG0776	regulation of translation
GRF56_14185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GRF56_14190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GRF56_14195	COG0740	serine-type endopeptidase activity
GRF56_14200	COG0544	peptidyl-prolyl cis-trans isomerase activity
GRF56_14210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GRF56_14215	COG4591	ABC-type transport system involved in lipoprotein release permease component
GRF56_14220	COG1136	(ABC) transporter
GRF56_14225	COG4591	ABC-type transport system involved in lipoprotein release permease component
GRF56_14240	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GRF56_14245	COG4166	transmembrane transport
GRF56_14255	COG1882	Formate acetyltransferase
GRF56_14260	COG2116	formate transmembrane transporter activity
GRF56_14265	COG1944	ATP diphosphatase activity
GRF56_14270	COG2723	6-phospho-beta-galactosidase activity
GRF56_14275	COG0583	DNA-binding transcription factor activity
GRF56_14285	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GRF56_14290	COG0583	DNA-binding transcription factor activity
GRF56_14300	COG1335	isochorismatase
GRF56_14310	COG2271	Major facilitator Superfamily
GRF56_14315	COG0583	DNA-binding transcription factor activity
GRF56_14320	COG0583	DNA-binding transcription factor activity
GRF56_14325	COG2910	NAD(P)H-binding
GRF56_14355	COG0861	Integral membrane protein TerC family
GRF56_14360	COG2885	chlorophyll binding
GRF56_14365	COG2199	diguanylate cyclase activity
GRF56_14385	COG2154	pterin-4-alpha-carbinolamine dehydratase
GRF56_14395	COG3768	UPF0283 membrane protein
GRF56_14400	COG3106	COG3106 Predicted ATPase
GRF56_14415	COG1842	Phage shock protein A
GRF56_14420	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GRF56_14430	COG4168	peptide transport system, permease
GRF56_14435	COG4171	peptide transport system, permease
GRF56_14440	COG4172	Belongs to the ABC transporter superfamily
GRF56_14445	COG4172	Belongs to the ABC transporter superfamily
GRF56_14450	COG0326	Molecular chaperone. Has ATPase activity
GRF56_14455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GRF56_14475	COG1435	thymidine kinase activity
GRF56_14480	COG1757	Na H antiporter
GRF56_14485	COG2916	Histone family protein nucleoid-structuring protein H-NS
GRF56_14490	COG2096	Adenosyltransferase
GRF56_14495	COG3530	Putative quorum-sensing-regulated virulence factor
GRF56_14500	COG0602	queuosine metabolic process
GRF56_14505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GRF56_14525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GRF56_14535	COG0776	regulation of translation
GRF56_14540	COG0539	negative regulation of cytoplasmic translation
GRF56_14545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GRF56_14550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRF56_14565	COG2814	Major facilitator Superfamily
GRF56_14585	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GRF56_14590	COG5001	Diguanylate cyclase
GRF56_14590	COG3300	MHYT domain
GRF56_14595	COG0583	DNA-binding transcription factor activity
GRF56_14600	COG3437	response regulator, receiver
GRF56_14625	COG4989	oxidoreductase activity
GRF56_14630	COG0724	RNA recognition motif
GRF56_14640	COG1126	abc transporter atp-binding protein
GRF56_14645	COG0765	amino acid transport
GRF56_14650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_14655	COG4597	amino acid ABC transporter
GRF56_14660	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GRF56_14670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GRF56_14685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GRF56_14690	COG1360	Flagellar Motor Protein
GRF56_14695	COG4771	TonB-dependent receptor
GRF56_14700	COG1770	oligopeptidase
GRF56_14720	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_14725	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_14730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_14730	COG0649	NAD binding
GRF56_14745	COG1034	ATP synthesis coupled electron transport
GRF56_14750	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GRF56_14755	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_14760	COG0839	Belongs to the complex I subunit 6 family
GRF56_14765	COG0713	ATP synthesis coupled electron transport
GRF56_14775	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_14780	COG1007	ATP synthesis coupled electron transport
GRF56_14795	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRF56_14795	COG2199	diguanylate cyclase activity
GRF56_14800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GRF56_14800	COG0047	phosphoribosylformylglycinamidine synthase activity
GRF56_14805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GRF56_14810	COG1645	bacterial-type flagellum-dependent swarming motility
GRF56_14815	COG1160	GTP binding
GRF56_14820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GRF56_14825	COG2976	Protein conserved in bacteria
GRF56_14830	COG0124	histidyl-tRNA synthetase
GRF56_14850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GRF56_14855	COG0105	UTP biosynthetic process
GRF56_14870	COG0633	Ferredoxin
GRF56_14875	COG0443	Heat shock 70 kDa protein
GRF56_14880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GRF56_14890	COG0822	iron-sulfur transferase activity
GRF56_14895	COG1104	cysteine desulfurase activity
GRF56_14945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRF56_14950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GRF56_14955	COG1862	Preprotein translocase
GRF56_14960	COG0343	queuine tRNA-ribosyltransferase activity
GRF56_14965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GRF56_14970	COG0517	IMP dehydrogenase activity
GRF56_14975	COG0450	alkyl hydroperoxide reductase
GRF56_14980	COG3634	alkyl hydroperoxide reductase activity
GRF56_15025	COG1242	4 iron, 4 sulfur cluster binding
GRF56_15030	COG0069	glutamate synthase activity
GRF56_15030	COG0067	glutamate synthase
GRF56_15030	COG0070	glutamate synthase
GRF56_15035	COG0493	'glutamate synthase
GRF56_15045	COG0513	Belongs to the DEAD box helicase family
GRF56_15070	COG0023	Translation Initiation Factor
GRF56_15075	COG2119	membrane
GRF56_15120	COG0215	cysteine-tRNA ligase activity
GRF56_15125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GRF56_15135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GRF56_15145	COG2261	transglycosylase associated protein
GRF56_15150	COG0642	Histidine kinase
GRF56_15195	COG0322	excinuclease ABC activity
GRF56_15200	COG2197	response regulator
GRF56_15205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GRF56_15210	COG2835	tetraacyldisaccharide 4'-kinase activity
GRF56_15215	COG1663	tetraacyldisaccharide 4'-kinase activity
GRF56_15225	COG2333	competence protein COMEC
GRF56_15225	COG0658	competence protein
GRF56_15240	COG1448	Aminotransferase
GRF56_15250	COG0583	DNA-binding transcription factor activity
GRF56_15255	COG3085	chromosome segregation
GRF56_15260	COG4574	serine-type endopeptidase inhibitor activity
GRF56_15265	COG0584	glycerophosphoryl diester phosphodiesterase
GRF56_15275	COG1349	DNA-binding transcription factor activity
GRF56_15280	COG2271	Major facilitator Superfamily
GRF56_15285	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRF56_15290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GRF56_15295	COG0840	transmembrane signaling receptor activity
GRF56_15305	COG0583	DNA-binding transcription factor activity
GRF56_15330	COG2814	Major facilitator Superfamily
GRF56_15335	COG2249	NAD(P)H dehydrogenase (quinone) activity
GRF56_15350	COG3220	belongs to the UPF0276 family
GRF56_15370	COG1294	oxidase, subunit
GRF56_15380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRF56_15390	COG2979	Protein of unknown function (DUF533)
GRF56_15395	COG1607	acyl-coa hydrolase
GRF56_15405	COG0583	DNA-binding transcription factor activity
GRF56_15415	COG2807	transmembrane transport
GRF56_15420	COG1187	pseudouridine synthase activity
GRF56_15430	COG0346	lactoylglutathione lyase activity
GRF56_15440	COG1403	HNH endonuclease
GRF56_15445	COG4657	Part of a membrane complex involved in electron transport
GRF56_15450	COG2878	Part of a membrane complex involved in electron transport
GRF56_15460	COG4658	electron transport chain
GRF56_15465	COG4659	FMN binding
GRF56_15475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GRF56_15480	COG0346	lactoylglutathione lyase activity
GRF56_15520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GRF56_15525	COG0505	Belongs to the CarA family
GRF56_15530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GRF56_15545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GRF56_15550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GRF56_15555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GRF56_15560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GRF56_15565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GRF56_15575	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GRF56_15605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GRF56_15610	COG0861	Integral membrane protein TerC family
GRF56_15620	COG0444	Belongs to the ABC transporter superfamily
GRF56_15625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRF56_15630	COG0601	transmembrane transport
GRF56_15640	COG2095	MarC family integral membrane protein
GRF56_15645	COG1012	belongs to the aldehyde dehydrogenase family
GRF56_15645	COG1454	alcohol dehydrogenase
GRF56_15660	COG0217	transcriptional regulatory protein
GRF56_15665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GRF56_15675	COG1801	Protein of unknown function DUF72
GRF56_15680	COG4106	trans-aconitate 2-methyltransferase activity
GRF56_15685	COG0500	methyltransferase
GRF56_15705	COG0450	alkyl hydroperoxide reductase
GRF56_15710	COG0583	DNA-binding transcription factor activity
GRF56_15715	COG0791	NLP P60 protein
GRF56_15725	COG0583	DNA-binding transcription factor activity
GRF56_15730	COG2610	gluconate transmembrane transporter activity
GRF56_15735	COG3048	D-serine ammonia-lyase activity
GRF56_15745	COG0538	isocitrate dehydrogenase activity
GRF56_15750	COG2207	Transcriptional regulator
GRF56_15760	COG3537	Alpha-1,2-mannosidase
GRF56_15775	COG3537	Alpha-1,2-mannosidase
GRF56_15780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_15795	COG3152	Membrane
GRF56_15830	COG1309	transcriptional regulator
GRF56_15860	COG0534	Mate efflux family protein
GRF56_15870	COG2841	Protein conserved in bacteria
GRF56_15880	COG5001	Diguanylate cyclase
GRF56_15880	COG3300	MHYT domain
GRF56_15885	COG3132	Protein of unknown function, DUF480
GRF56_15915	COG0708	Exodeoxyribonuclease III
GRF56_15940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_15945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_15960	COG1120	ATPase activity
GRF56_15965	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRF56_15970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRF56_15975	COG4771	TonB-dependent receptor
GRF56_15980	COG2375	cellular response to nickel ion
GRF56_15985	COG0784	Response regulator, receiver
GRF56_15985	COG3437	response regulator, receiver
GRF56_15995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GRF56_16000	COG0328	RNA-DNA hybrid ribonuclease activity
GRF56_16005	COG2226	methyltransferase
GRF56_16010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GRF56_16015	COG1388	LysM domain
GRF56_16015	COG0741	lytic transglycosylase activity
GRF56_16040	COG5000	phosphorelay sensor kinase activity
GRF56_16040	COG5002	protein histidine kinase activity
GRF56_16045	COG0745	RESPONSE REGULATOR receiver
GRF56_16050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_16055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_16065	COG1376	ErfK ybiS ycfS ynhG family protein
GRF56_16065	COG1388	LysM domain
GRF56_16075	COG0471	metal ion transport
GRF56_16085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GRF56_16090	COG0791	NLP P60 protein
GRF56_16110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GRF56_16115	COG0788	formyltetrahydrofolate deformylase activity
GRF56_16125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GRF56_16140	COG0739	heme binding
GRF56_16140	COG1196	nuclear chromosome segregation
GRF56_16140	COG0741	lytic transglycosylase activity
GRF56_16145	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GRF56_16155	COG0436	Aminotransferase
GRF56_16160	COG1288	antiporter activity
GRF56_16165	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GRF56_16180	COG2964	Protein conserved in bacteria
GRF56_16185	COG3681	Belongs to the UPF0597 family
GRF56_16190	COG0251	oxidation-reduction process
GRF56_16195	COG0814	amino acid
GRF56_16215	COG1166	arginine decarboxylase activity
GRF56_16220	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRF56_16235	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GRF56_16245	COG2353	YceI-like domain
GRF56_16250	COG0583	DNA-binding transcription factor activity
GRF56_16260	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GRF56_16265	COG0840	transmembrane signaling receptor activity
GRF56_16270	COG0840	transmembrane signaling receptor activity
GRF56_16275	COG0302	gtp cyclohydrolase
GRF56_16280	COG0303	'Molybdopterin
GRF56_16285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GRF56_16305	COG2267	carboxylic ester hydrolase activity
GRF56_16310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GRF56_16325	COG0314	molybdopterin synthase activity
GRF56_16330	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GRF56_16335	COG0315	cyclic pyranopterin monophosphate synthase activity
GRF56_16340	COG0521	Mo-molybdopterin cofactor biosynthetic process
GRF56_16345	COG3005	denitrification pathway
GRF56_16355	COG0348	domain, Protein
GRF56_16360	COG0437	4 iron, 4 sulfur cluster binding
GRF56_16365	COG0243	molybdopterin cofactor binding
GRF56_16375	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GRF56_16380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GRF56_16385	COG3850	Histidine kinase
GRF56_16390	COG2197	response regulator
GRF56_16405	COG2205	protein histidine kinase activity
GRF56_16405	COG0784	Response regulator, receiver
GRF56_16425	COG0121	glutamine amidotransferase
GRF56_16430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GRF56_16435	COG1960	acyl-CoA dehydrogenase activity
GRF56_16440	COG1473	amidohydrolase
GRF56_16450	COG2867	negative regulation of translational initiation
GRF56_16455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GRF56_16510	COG3561	AntA/AntB antirepressor
GRF56_16750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GRF56_16780	COG2974	May be involved in recombination
GRF56_16845	COG0784	Response regulator, receiver
GRF56_16845	COG2205	protein histidine kinase activity
GRF56_16855	COG3383	formate dehydrogenase (NAD+) activity
GRF56_16865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GRF56_16875	COG1960	acyl-CoA dehydrogenase activity
GRF56_16880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_16890	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GRF56_16895	COG1317	bacterial-type flagellum organization
GRF56_16985	COG0457	Tetratricopeptide repeat
GRF56_17055	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRF56_17060	COG4790	Type iii secretion
GRF56_17065	COG4794	Type iii secretion
GRF56_17070	COG4791	protein targeting
GRF56_17075	COG4792	protein secretion
GRF56_17090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GRF56_17095	COG1263	PTS System
GRF56_17095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GRF56_17100	COG1609	Transcriptional regulator
GRF56_17130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_17130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_17130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_17135	COG2271	Major facilitator Superfamily
GRF56_17140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GRF56_17150	COG1187	pseudouridine synthase activity
GRF56_17160	COG0482	sulfurtransferase activity
GRF56_17165	COG2915	High frequency lysogenization protein hflD homolog
GRF56_17170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GRF56_17175	COG2850	peptidyl-arginine hydroxylation
GRF56_17200	COG0259	pyridoxamine-phosphate oxidase activity
GRF56_17230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GRF56_17230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GRF56_17240	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GRF56_17255	COG2853	Lipoprotein
GRF56_17265	COG4235	cytochrome complex assembly
GRF56_17265	COG3088	subunit of a heme lyase
GRF56_17270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRF56_17275	COG1138	Cytochrome C-type biogenesis protein
GRF56_17280	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GRF56_17285	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GRF56_17290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GRF56_17295	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GRF56_17310	COG0835	chemotaxis
GRF56_17320	COG1192	Involved in chromosome partitioning
GRF56_17325	COG1360	Flagellar Motor Protein
GRF56_17330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GRF56_17340	COG2198	Histidine kinase
GRF56_17340	COG0643	Histidine kinase
GRF56_17345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GRF56_17360	COG0455	bacterial-type flagellum organization
GRF56_17370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GRF56_17380	COG1684	flagellar biosynthetic protein fliR
GRF56_17385	COG1987	bacterial-type flagellum assembly
GRF56_17435	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRF56_17445	COG1677	Flagellar hook-basal body complex protein FliE
GRF56_17465	COG0469	pyruvate kinase activity
GRF56_17470	COG1737	Transcriptional regulator
GRF56_17475	COG0837	glucose binding
GRF56_17505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GRF56_17525	COG0281	malic enzyme
GRF56_17545	COG0437	4 iron, 4 sulfur cluster binding
GRF56_17550	COG3383	formate dehydrogenase (NAD+) activity
GRF56_17550	COG3383	formate dehydrogenase (NAD+) activity
GRF56_17590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GRF56_17600	COG3852	Histidine kinase
GRF56_17605	COG2204	response regulator
GRF56_17615	COG4662	Binding-protein-dependent transport system inner membrane component
GRF56_17625	COG0746	molybdenum cofactor guanylyltransferase activity
GRF56_17630	COG0303	'Molybdopterin
GRF56_17635	COG1289	transmembrane transporter activity
GRF56_17640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GRF56_17670	COG3220	belongs to the UPF0276 family
GRF56_17700	COG0784	Response regulator, receiver
GRF56_17700	COG2205	protein histidine kinase activity
GRF56_17715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GRF56_17720	COG0444	Belongs to the ABC transporter superfamily
GRF56_17725	COG4608	Belongs to the ABC transporter superfamily
GRF56_17735	COG2971	BadF BadG BcrA BcrD
GRF56_17745	COG0840	transmembrane signaling receptor activity
GRF56_17755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GRF56_17760	COG3724	N-succinylarginine dihydrolase activity
GRF56_17790	COG2197	response regulator
GRF56_17815	COG2199	diguanylate cyclase activity
GRF56_17815	COG2203	Gaf domain
GRF56_17815	COG2200	EAL domain
GRF56_17825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GRF56_17835	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GRF56_17840	COG3706	GGDEF domain
GRF56_17845	COG2211	Major facilitator Superfamily
GRF56_17850	COG0616	signal peptide processing
GRF56_17855	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_17860	COG0583	DNA-binding transcription factor activity
GRF56_17870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GRF56_17890	COG1881	PFAM PEBP family protein
GRF56_17905	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GRF56_17920	COG1301	dicarboxylic acid transport
GRF56_17925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GRF56_17930	COG2912	Transglutaminase-like superfamily
GRF56_17940	COG2890	protein-(glutamine-N5) methyltransferase activity
GRF56_17945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GRF56_17950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GRF56_17955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GRF56_17960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GRF56_17970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GRF56_17975	COG0737	Belongs to the 5'-nucleotidase family
GRF56_17980	COG0193	aminoacyl-tRNA hydrolase activity
GRF56_17985	COG0012	GTP binding
GRF56_17995	COG5377	YqaJ viral recombinase family
GRF56_18025	COG1484	DNA-dependent DNA replication
GRF56_18030	COG4584	PFAM Integrase catalytic
GRF56_18050	COG2003	Belongs to the UPF0758 family
GRF56_18075	COG4133	protoheme IX ABC transporter activity
GRF56_18135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GRF56_18225	COG0490	domain, Protein
GRF56_18225	COG0471	metal ion transport
GRF56_18235	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GRF56_18255	COG0366	Alpha amylase catalytic
GRF56_18260	COG0674	pyruvate-flavodoxin oxidoreductase activity
GRF56_18260	COG1013	pyruvate-flavodoxin oxidoreductase activity
GRF56_18260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GRF56_18260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GRF56_18270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRF56_18285	COG1012	belongs to the aldehyde dehydrogenase family
GRF56_18295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GRF56_18300	COG0512	Glutamine amidotransferase of anthranilate synthase
GRF56_18310	COG0180	Tryptophanyl-tRNA synthetase
GRF56_18320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GRF56_18325	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GRF56_18335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GRF56_18340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GRF56_18370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GRF56_18375	COG0583	DNA-binding transcription factor activity
GRF56_18395	COG0583	DNA-binding transcription factor activity
GRF56_18405	COG0739	heme binding
GRF56_18415	COG1511	domain protein
GRF56_18415	COG3264	Mechanosensitive ion channel
GRF56_18420	COG0584	glycerophosphoryl diester phosphodiesterase
GRF56_18430	COG1053	succinate dehydrogenase
GRF56_18435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GRF56_18440	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GRF56_18445	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GRF56_18450	COG3366	ferrous iron transmembrane transporter activity
GRF56_18455	COG0700	Nucleoside recognition
GRF56_18460	COG2195	Cleaves the N-terminal amino acid of tripeptides
GRF56_18485	COG1022	Amp-dependent synthetase and ligase
GRF56_18495	COG4221	oxidoreductase activity
GRF56_18505	COG0745	RESPONSE REGULATOR receiver
GRF56_18510	COG0642	Histidine kinase
GRF56_18530	COG0516	GMP reductase activity
GRF56_18540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GRF56_18555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GRF56_18590	COG3706	GGDEF domain
GRF56_18600	COG1335	isochorismatase
GRF56_18605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GRF56_18610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GRF56_18615	COG1702	phosphate starvation-inducible protein PhoH
GRF56_18620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GRF56_18625	COG4535	Mg2 and Co2 transporter CorC
GRF56_18630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GRF56_18635	COG0789	Transcriptional regulator
GRF56_18650	COG1970	mechanosensitive ion channel activity
GRF56_18660	COG4974	Belongs to the 'phage' integrase family
GRF56_18665	COG0716	FMN binding
GRF56_18675	COG0312	modulator of DNA gyrase
GRF56_18680	COG2888	peptidyl-tyrosine sulfation
GRF56_18685	COG0495	leucyl-tRNA aminoacylation
GRF56_18700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GRF56_18705	COG0799	negative regulation of ribosome biogenesis
GRF56_18710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GRF56_18715	COG0768	penicillin binding
GRF56_18720	COG0772	Belongs to the SEDS family
GRF56_18725	COG2951	lytic endotransglycosylase activity
GRF56_18730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GRF56_18735	COG1686	Belongs to the peptidase S11 family
GRF56_18740	COG2921	Belongs to the UPF0250 family
GRF56_18745	COG0321	lipoyl(octanoyl) transferase activity
GRF56_18750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GRF56_18770	COG3139	Protein of unknown function (DUF1315)
GRF56_18775	COG0252	asparaginase activity
GRF56_18780	COG0786	glutamate:sodium symporter activity
GRF56_18795	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GRF56_18800	COG0384	phenazine biosynthesis protein PhzF
GRF56_18805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GRF56_18810	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GRF56_18825	COG3610	response to peptide
GRF56_18830	COG2966	Psort location CytoplasmicMembrane, score
GRF56_18840	COG0521	Mo-molybdopterin cofactor biosynthetic process
GRF56_18855	COG2897	thiosulfate sulfurtransferase activity
GRF56_18860	COG2066	Belongs to the glutaminase family
GRF56_18865	COG3171	Protein conserved in bacteria
GRF56_18870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GRF56_18875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRF56_18880	COG2200	EAL domain
GRF56_18885	COG1090	epimerase
GRF56_18890	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GRF56_18895	COG4181	ATPase activity
GRF56_18900	COG2755	lipolytic protein G-D-S-L family
GRF56_18905	COG0784	Response regulator, receiver
GRF56_18905	COG0835	chemotaxis
GRF56_18950	COG3397	chitin binding
GRF56_18975	COG0784	Response regulator, receiver
GRF56_18975	COG5002	protein histidine kinase activity
GRF56_18975	COG2205	protein histidine kinase activity
GRF56_18985	COG3655	Transcriptional regulator
GRF56_18995	COG2814	Major facilitator Superfamily
GRF56_19020	COG0748	coenzyme F420 binding
GRF56_19025	COG3721	Heme iron utilization protein
GRF56_19035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GRF56_19055	COG0432	Pfam Uncharacterised protein family UPF0047
GRF56_19060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GRF56_19065	COG0305	Participates in initiation and elongation during chromosome replication
GRF56_19075	COG1047	Peptidyl-prolyl cis-trans
GRF56_19080	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GRF56_19090	COG0784	Response regulator, receiver
GRF56_19090	COG0835	chemotaxis
GRF56_19095	COG0429	hydrolase of the alpha beta-hydrolase fold
GRF56_19100	COG2203	Gaf domain
GRF56_19100	COG5001	Diguanylate cyclase
GRF56_19100	COG4251	negative regulation of phosphorylation
GRF56_19100	COG3706	GGDEF domain
GRF56_19105	COG3089	Belongs to the UPF0270 family
GRF56_19110	COG3954	Phosphoribulokinase
GRF56_19125	COG1765	OsmC-like protein
GRF56_19130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GRF56_19165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GRF56_19170	COG2313	pseudouridylate synthase activity
GRF56_19195	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
GRF56_19215	COG0569	domain protein
GRF56_19215	COG2985	domain, Protein
GRF56_19220	COG1272	protein, Hemolysin III
GRF56_19225	COG0076	glutamate decarboxylase activity
GRF56_19230	COG2917	probably involved in intracellular septation
GRF56_19235	COG2350	Protein conserved in bacteria
GRF56_19245	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GRF56_19250	COG1381	Involved in DNA repair and RecF pathway recombination
GRF56_19265	COG0681	Belongs to the peptidase S26 family
GRF56_19270	COG0481	GTPase activity
GRF56_19280	COG3026	antisigma factor binding
GRF56_19285	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
GRF56_19290	COG1595	DNA-templated transcription, initiation
GRF56_19295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GRF56_19305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GRF56_19310	COG0354	folic acid binding
GRF56_19335	COG4232	protein-disulfide reductase activity
GRF56_19350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GRF56_19355	COG0191	fructose-bisphosphate aldolase activity
GRF56_19360	COG0126	phosphoglycerate kinase activity
GRF56_19365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GRF56_19370	COG1940	carbohydrate kinase activity
GRF56_19375	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GRF56_19380	COG2816	NAD+ diphosphatase activity
GRF56_19390	COG4991	sh3 domain protein
GRF56_19395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GRF56_19405	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GRF56_19445	COG2816	NAD+ diphosphatase activity
GRF56_19485	COG1858	cytochrome C peroxidase
GRF56_19490	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
GRF56_19500	COG2203	Gaf domain
GRF56_19500	COG2199	diguanylate cyclase activity
GRF56_19505	COG0513	Belongs to the DEAD box helicase family
GRF56_19530	COG0154	amidase activity
GRF56_19535	COG2957	Belongs to the agmatine deiminase family
GRF56_19550	COG1902	pentaerythritol trinitrate reductase activity
GRF56_19565	COG1238	metal cluster binding
GRF56_19570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GRF56_19575	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GRF56_19580	COG0585	pseudouridine synthase activity
GRF56_19590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GRF56_19595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GRF56_19600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GRF56_19610	COG1376	ErfK ybiS ycfS ynhG family protein
GRF56_19615	COG0668	transmembrane transport
GRF56_19625	COG2731	YhcH YjgK YiaL family protein
GRF56_19635	COG1794	racemase activity, acting on amino acids and derivatives
GRF56_19650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GRF56_19670	COG0488	(ABC) transporter
GRF56_19680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GRF56_19725	COG0148	phosphopyruvate hydratase activity
GRF56_19730	COG0504	CTP synthase activity
GRF56_19735	COG3956	TIGRFAM MazG family protein
GRF56_19740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GRF56_19745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GRF56_19755	COG4807	Protein conserved in bacteria
GRF56_19760	COG3023	N-Acetylmuramoyl-L-alanine amidase
GRF56_19765	COG0783	Belongs to the Dps family
GRF56_19770	COG1151	hydroxylamine reductase activity
GRF56_19780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GRF56_19785	COG0671	phosphoesterase, PA-phosphatase related
GRF56_19790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GRF56_19795	COG0163	prenyltransferase activity
GRF56_19810	COG1131	(ABC) transporter
GRF56_19815	COG0842	Transport permease protein
GRF56_19820	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
GRF56_19825	COG1924	4 iron, 4 sulfur cluster binding
GRF56_19855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GRF56_19860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GRF56_19865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GRF56_19875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GRF56_19880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GRF56_19885	COG1489	DNA binding
GRF56_19895	COG1643	Atp-dependent helicase
GRF56_19900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GRF56_19905	COG0346	lactoylglutathione lyase activity
GRF56_19910	COG2076	Multidrug Resistance protein
GRF56_19915	COG2076	Multidrug Resistance protein
GRF56_19925	COG0784	Response regulator, receiver
GRF56_19925	COG3437	response regulator, receiver
GRF56_19930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GRF56_19945	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GRF56_19980	COG0840	transmembrane signaling receptor activity
GRF56_20005	COG0529	Catalyzes the synthesis of activated sulfate
GRF56_20010	COG3273	potassium ion transport
GRF56_20010	COG0471	metal ion transport
GRF56_20015	COG2895	sulfate adenylyltransferase (ATP) activity
GRF56_20020	COG0175	sulfate reduction
GRF56_20025	COG1648	precorrin-2 dehydrogenase activity
GRF56_20025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GRF56_20030	COG0330	HflC and HflK could
GRF56_20035	COG1585	Membrane protein implicated in regulation of membrane protease activity
GRF56_20040	COG0840	transmembrane signaling receptor activity
GRF56_20045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GRF56_20055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GRF56_20060	COG1640	4-alpha-glucanotransferase
GRF56_20065	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GRF56_20100	COG1522	sequence-specific DNA binding
GRF56_20115	COG0561	phosphatase activity
GRF56_20130	COG0733	neurotransmitter:sodium symporter activity
GRF56_20140	COG0733	neurotransmitter:sodium symporter activity
GRF56_20205	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GRF56_20210	COG2885	chlorophyll binding
GRF56_20215	COG0823	Involved in the tonB-independent uptake of proteins
GRF56_20230	COG0811	peptide transport
GRF56_20235	COG0824	Thioesterase
GRF56_20240	COG3790	cyd operon protein YbgE
GRF56_20245	COG4890	Cyd operon protein YbgT
GRF56_20250	COG1294	oxidase, subunit
GRF56_20260	COG2255	four-way junction helicase activity
GRF56_20265	COG0632	four-way junction helicase activity
GRF56_20270	COG0840	transmembrane signaling receptor activity
GRF56_20280	COG2771	luxR family
GRF56_20285	COG3916	Acyl-homoserine-lactone synthase
GRF56_20295	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GRF56_20300	COG4251	negative regulation of phosphorylation
GRF56_20300	COG3706	GGDEF domain
GRF56_20300	COG2203	Gaf domain
GRF56_20300	COG5001	Diguanylate cyclase
GRF56_20310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GRF56_20320	COG2995	paraquat-inducible protein a
GRF56_20325	COG3008	intermembrane lipid transfer
GRF56_20325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GRF56_20335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GRF56_20340	COG0442	prolyl-tRNA aminoacylation
GRF56_20345	COG4221	oxidoreductase activity
GRF56_20360	COG1024	Enoyl-CoA hydratase
GRF56_20370	COG0110	maltose O-acetyltransferase activity
GRF56_20380	COG4166	transmembrane transport
GRF56_20390	COG0840	transmembrane signaling receptor activity
GRF56_20395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GRF56_20400	COG0735	belongs to the Fur family
GRF56_20425	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GRF56_20430	COG0513	Belongs to the DEAD box helicase family
GRF56_20435	COG2153	protein acetylation
GRF56_20445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GRF56_20450	COG0557	exoribonuclease II activity
GRF56_20455	COG3706	GGDEF domain
GRF56_20465	COG3240	lipase activity
GRF56_20470	COG3111	PFAM Bacterial OB fold (BOF) protein
GRF56_20480	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GRF56_20485	COG1194	a g-specific adenine glycosylase
GRF56_20490	COG0617	tRNA 3'-terminal CCA addition
GRF56_20510	COG3068	Protein conserved in bacteria
GRF56_20520	COG0739	heme binding
GRF56_20540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GRF56_20545	COG1121	(ABC) transporter
GRF56_20550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GRF56_20555	COG0583	DNA-binding transcription factor activity
GRF56_20560	COG0697	spore germination
GRF56_20565	COG1573	uracil-dna glycosylase
GRF56_20580	COG2827	Endonuclease containing a URI domain
GRF56_20595	COG1842	Phage shock protein A
GRF56_20600	COG0204	Acyl-transferase
GRF56_20620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GRF56_20630	COG2084	Dehydrogenase
GRF56_20660	COG3104	oligopeptide transport
GRF56_20670	COG0583	DNA-binding transcription factor activity
GRF56_20685	COG0187	DNA topoisomerase II activity
GRF56_20690	COG3150	esterase
GRF56_20700	COG3151	Protein conserved in bacteria
GRF56_20705	COG0494	nUDIX hydrolase
GRF56_20710	COG1538	Outer membrane efflux protein
GRF56_20715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GRF56_20715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GRF56_20720	COG1560	Kdo2-lipid A biosynthetic process
GRF56_20725	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_20725	COG2213	PTS system mannitol-specific
GRF56_20730	COG0246	Mannitol dehydrogenase
GRF56_20735	COG3722	fumarate hydratase activity
GRF56_20765	COG1671	Belongs to the UPF0178 family
GRF56_20770	COG1988	membrane-bound metal-dependent
GRF56_20780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GRF56_20785	COG0513	Belongs to the DEAD box helicase family
GRF56_20805	COG1575	Belongs to the MenA family. Type 1 subfamily
GRF56_20810	COG1169	isochorismate synthase
GRF56_20815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GRF56_20820	COG0596	Alpha beta hydrolase
GRF56_20825	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GRF56_20830	COG1441	menaquinone biosynthetic process
GRF56_20835	COG0318	PFAM AMP-dependent synthetase and ligase
GRF56_20850	COG3539	Fimbrial protein
GRF56_20855	COG3121	Chaperone
GRF56_20860	COG3188	usher protein
GRF56_20870	COG3539	Fimbrial protein
GRF56_20880	COG3291	Pkd domain containing protein
GRF56_20885	COG2949	membrane
GRF56_20890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GRF56_20900	COG0784	Response regulator, receiver
GRF56_20900	COG0835	chemotaxis
GRF56_20905	COG1028	Short-chain dehydrogenase reductase Sdr
GRF56_20910	COG1444	tRNA N-acetyltransferase activity
GRF56_20930	COG1803	Methylglyoxal synthase
GRF56_20935	COG1979	alcohol dehydrogenase
GRF56_20950	COG4221	oxidoreductase activity
GRF56_20990	COG1368	sulfuric ester hydrolase activity
GRF56_20995	COG1522	sequence-specific DNA binding
GRF56_21005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GRF56_21010	COG1418	mRNA catabolic process
GRF56_21015	COG1058	Belongs to the CinA family
GRF56_21015	COG1546	Belongs to the CinA family
GRF56_21025	COG0561	phosphatase activity
GRF56_21035	COG2926	Belongs to the UPF0265 family
GRF56_21075	COG1396	sequence-specific DNA binding
GRF56_21080	COG3135	benzoate transporter
GRF56_21105	COG0840	transmembrane signaling receptor activity
GRF56_21110	COG3047	cAMP biosynthetic process
GRF56_21115	COG3706	GGDEF domain
GRF56_21120	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GRF56_21140	COG1462	curli production assembly transport component CsgG
GRF56_21155	COG2197	response regulator
GRF56_21175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GRF56_21185	COG1278	Cold shock
GRF56_21190	COG2252	PERMEase
GRF56_21195	COG2376	Dihydroxyacetone kinase
GRF56_21200	COG1461	Dihydroxyacetone kinase
GRF56_21205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_21205	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GRF56_21205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GRF56_21215	COG3284	Transcriptional regulator
GRF56_21235	COG0628	permease
GRF56_21240	COG0494	nUDIX hydrolase
GRF56_21255	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GRF56_21280	COG0456	acetyltransferase
GRF56_21285	COG3133	Outer membrane lipoprotein
GRF56_21290	COG0004	ammonium transporteR
GRF56_21295	COG3706	GGDEF domain
GRF56_21305	COG3932	Exopolysaccharide synthesis, ExoD
GRF56_21340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GRF56_21345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GRF56_21360	COG0477	Major facilitator Superfamily
GRF56_21370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GRF56_21375	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GRF56_21380	COG0523	cobalamin synthesis protein
GRF56_21390	COG2200	EAL domain
GRF56_21395	COG1049	propionate catabolic process, 2-methylcitrate cycle
GRF56_21400	COG1752	Esterase of the alpha-beta hydrolase superfamily
GRF56_21405	COG0840	transmembrane signaling receptor activity
GRF56_21415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GRF56_21420	COG0508	dehydrogenase complex catalyzes the overall conversion of
GRF56_21425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GRF56_21430	COG2186	Transcriptional regulator
GRF56_21455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GRF56_21460	COG1459	type II secretion system
GRF56_21475	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GRF56_21480	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GRF56_21485	COG0494	nUDIX hydrolase
GRF56_21490	COG0653	protein targeting
GRF56_21500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GRF56_21505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GRF56_21510	COG0849	cell division
GRF56_21520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GRF56_21525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GRF56_21530	COG0772	Belongs to the SEDS family
GRF56_21535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GRF56_21540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GRF56_21545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GRF56_21555	COG0768	penicillin binding
GRF56_21560	COG3116	cell division
GRF56_21565	COG0275	rRNA processing
GRF56_21570	COG2001	Belongs to the MraZ family
GRF56_21580	COG1388	LysM domain
GRF56_21580	COG0741	lytic transglycosylase activity
GRF56_21595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GRF56_21600	COG1191	sigma factor activity
GRF56_21625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GRF56_21630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRF56_21640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GRF56_21645	COG4786	Flagellar basal body rod
GRF56_21645	COG1256	bacterial-type flagellum assembly
GRF56_21655	COG1706	bacterial-type flagellum-dependent cell motility
GRF56_21660	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GRF56_21665	COG4786	Flagellar basal body rod
GRF56_21670	COG4787	bacterial-type flagellum-dependent cell motility
GRF56_21675	COG1749	Flagellar hook protein flgE
GRF56_21680	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GRF56_21685	COG1558	bacterial-type flagellum-dependent cell motility
GRF56_21690	COG1815	bacterial-type flagellum-dependent cell motility
GRF56_21695	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GRF56_21725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GRF56_21735	COG1677	Flagellar hook-basal body complex protein FliE
GRF56_21740	COG2204	response regulator
GRF56_21760	COG1987	bacterial-type flagellum assembly
GRF56_21785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GRF56_21790	COG3107	peptidoglycan biosynthetic process
GRF56_21795	COG0792	nuclease activity
GRF56_21800	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GRF56_21805	COG2823	Periplasmic or secreted lipoprotein
GRF56_21810	COG2969	positive regulation of protein catabolic process
GRF56_21815	COG0625	glutathione transferase activity
GRF56_21820	COG2857	Cytochrome c1
GRF56_21825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GRF56_21830	COG0723	plastoquinol--plastocyanin reductase activity
GRF56_21835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GRF56_21840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GRF56_21845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GRF56_21855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRF56_21860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GRF56_21890	COG3964	amidohydrolase
GRF56_21905	COG3711	transcriptional antiterminator
GRF56_21905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_21910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_21915	COG1660	Displays ATPase and GTPase activities
GRF56_21920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GRF56_21935	COG1137	ATPase activity
GRF56_21940	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GRF56_21945	COG3117	lipopolysaccharide transmembrane transporter activity
GRF56_21950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GRF56_21955	COG0517	IMP dehydrogenase activity
GRF56_21955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GRF56_21960	COG1127	ABC transporter
GRF56_21965	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GRF56_21970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GRF56_21975	COG2854	intermembrane phospholipid transfer
GRF56_21985	COG5007	Belongs to the BolA IbaG family
GRF56_21990	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GRF56_21995	COG0312	modulator of DNA gyrase
GRF56_22000	COG3028	Belongs to the UPF0307 family
GRF56_22005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GRF56_22025	COG1011	Hydrolase
GRF56_22040	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GRF56_22045	COG0019	diaminopimelate decarboxylase activity
GRF56_22055	COG1965	Belongs to the frataxin family
GRF56_22060	COG0400	carboxylic ester hydrolase activity
GRF56_22065	COG3072	Adenylate cyclase
GRF56_22070	COG0181	hydroxymethylbilane synthase activity
GRF56_22080	COG2959	enzyme of heme biosynthesis
GRF56_22095	COG1494	fructose-1,6-bisphosphatase
GRF56_22115	COG0531	amino acid
GRF56_22140	COG4974	Belongs to the 'phage' integrase family
GRF56_22155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GRF56_22230	COG4695	Portal protein