locus-tag	class	description
B565_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B565_0002	COG0592	DNA-directed DNA polymerase activity
B565_0004	COG0187	DNA topoisomerase II activity
B565_0006	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B565_0007	COG0071	Belongs to the small heat shock protein (HSP20) family
B565_0008	COG0071	Belongs to the small heat shock protein (HSP20) family
B565_0009	COG3977	Valine--pyruvate aminotransferase
B565_0011	COG2814	Major facilitator Superfamily
B565_0012	COG0745	RESPONSE REGULATOR receiver
B565_0013	COG2205	protein histidine kinase activity
B565_0017	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B565_0018	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_0018	COG4191	Histidine kinase
B565_0019	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_0020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_0021	COG1309	transcriptional regulator
B565_0023	COG0561	phosphatase activity
B565_0024	COG2267	carboxylic ester hydrolase activity
B565_0026	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B565_0027	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B565_0028	COG1758	RNA polymerase activity
B565_0029	COG0194	GDP metabolic process
B565_0031	COG0859	PFAM glycosyl transferase family 9
B565_0032	COG3642	lipopolysaccharide core region biosynthetic process
B565_0040	COG0589	response to stress
B565_0041	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B565_0042	COG1528	Iron-storage protein
B565_0043	COG2081	HI0933 family
B565_0044	COG3275	phosphorelay sensor kinase activity
B565_0045	COG3279	Response regulator of the LytR AlgR family
B565_0046	COG2223	nitrite transmembrane transporter activity
B565_0047	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B565_0048	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B565_0051	COG0583	DNA-binding transcription factor activity
B565_0055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B565_0056	COG2166	iron-sulfur cluster assembly
B565_0057	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B565_0060	COG3245	cytochrome
B565_0061	COG1063	alcohol dehydrogenase
B565_0064	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B565_0066	COG3307	-O-antigen
B565_0067	COG1215	transferase activity, transferring glycosyl groups
B565_0072	COG1280	lysine exporter protein (LysE YggA)
B565_0079	COG1943	Transposase
B565_0080	COG0210	DNA helicase
B565_0085	COG0737	Belongs to the 5'-nucleotidase family
B565_0088	COG2239	Acts as a magnesium transporter
B565_0089	COG1648	precorrin-2 dehydrogenase activity
B565_0089	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B565_0090	COG2116	formate transmembrane transporter activity
B565_0091	COG2146	nitrite reductase [NAD(P)H] activity
B565_0092	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B565_0093	COG0842	Transport permease protein
B565_0094	COG0842	Transport permease protein
B565_0095	COG1131	(ABC) transporter
B565_0096	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_0098	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B565_0099	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B565_0101	COG0018	arginyl-trna synthetase
B565_0103	COG1595	DNA-templated transcription, initiation
B565_0105	COG1968	undecaprenyl-diphosphatase activity
B565_0106	COG2017	converts alpha-aldose to the beta-anomer
B565_0107	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B565_0108	COG1085	galactose-1-phosphate uridylyltransferase
B565_0109	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B565_0110	COG1609	Transcriptional regulator
B565_0111	COG3250	beta-galactosidase activity
B565_0113	COG1129	ABC transporter
B565_0114	COG4211	Belongs to the binding-protein-dependent transport system permease family
B565_0116	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B565_0120	COG0366	Alpha amylase catalytic
B565_0123	COG0443	Heat shock 70 kDa protein
B565_0124	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B565_0125	COG3045	CreA protein
B565_0128	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B565_0129	COG0174	glutamine synthetase
B565_0133	COG3842	ATPase activity
B565_0134	COG1176	ABC-type spermidine putrescine transport system, permease component I
B565_0135	COG1177	transmembrane transport
B565_0136	COG2258	MOSC domain
B565_0138	COG2050	protein possibly involved in aromatic compounds catabolism
B565_0139	COG0514	ATP-dependent DNA helicase (RecQ)
B565_0141	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B565_0143	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B565_0144	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B565_0147	COG0254	rRNA binding
B565_0148	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B565_0150	COG0702	epimerase
B565_0151	COG0814	amino acid
B565_0152	COG0281	malic enzyme
B565_0153	COG1295	ribonuclease BN
B565_0154	COG1490	D-aminoacyl-tRNA deacylase activity
B565_0155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B565_0156	COG0456	acetyltransferase
B565_0158	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B565_0159	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B565_0160	COG2610	gluconate transmembrane transporter activity
B565_0161	COG3265	gluconokinase activity
B565_0163	COG0800	Aldolase
B565_0164	COG1609	Transcriptional regulator
B565_0166	COG4942	peptidase
B565_0167	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B565_0168	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B565_0169	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B565_0170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B565_0171	COG0316	Belongs to the HesB IscA family
B565_0171	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B565_0172	COG1040	competence protein
B565_0173	COG0596	Alpha beta hydrolase
B565_0177	COG2183	response to ionizing radiation
B565_0178	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B565_0179	COG0745	RESPONSE REGULATOR receiver
B565_0182	COG0051	transcription antitermination factor activity, RNA binding
B565_0183	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B565_0184	COG0088	Forms part of the polypeptide exit tunnel
B565_0185	COG0089	rRNA binding
B565_0186	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B565_0187	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B565_0188	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B565_0189	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B565_0190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B565_0191	COG0255	Belongs to the universal ribosomal protein uL29 family
B565_0192	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B565_0193	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B565_0194	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B565_0195	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B565_0196	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B565_0197	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B565_0198	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B565_0199	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B565_0200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B565_0201	COG1841	ribosomal large subunit assembly
B565_0202	COG0200	Binds to the 23S rRNA
B565_0203	COG0201	protein transport
B565_0204	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B565_0205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B565_0206	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B565_0207	COG0202	RNA polymerase activity
B565_0208	COG0203	ribosomal protein L17
B565_0209	COG4771	TonB-dependent receptor
B565_0210	COG3706	GGDEF domain
B565_0212	COG0745	RESPONSE REGULATOR receiver
B565_0215	COG0583	DNA-binding transcription factor activity
B565_0217	COG1741	Belongs to the pirin family
B565_0218	COG2259	Doxx family
B565_0219	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B565_0220	COG1074	ATP-dependent DNA helicase activity
B565_0221	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B565_0224	COG3706	GGDEF domain
B565_0232	COG1175	transmembrane transport
B565_0234	COG3842	ATPase activity
B565_0240	COG2873	o-acetylhomoserine
B565_0242	COG4533	DNA binding
B565_0243	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B565_0246	COG5380	lipid catabolic process
B565_0247	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B565_0249	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B565_0254	COG0753	catalase activity
B565_0260	COG2927	DNA polymerase III (CHI subunit)
B565_0261	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B565_0262	COG0795	lipopolysaccharide-transporting ATPase activity
B565_0263	COG0795	lipopolysaccharide-transporting ATPase activity
B565_0269	COG0531	amino acid
B565_0273	COG1494	fructose-1,6-bisphosphatase
B565_0276	COG2959	enzyme of heme biosynthesis
B565_0278	COG0181	hydroxymethylbilane synthase activity
B565_0279	COG3072	Adenylate cyclase
B565_0280	COG0400	carboxylic ester hydrolase activity
B565_0281	COG1965	Belongs to the frataxin family
B565_0282	COG0019	diaminopimelate decarboxylase activity
B565_0283	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B565_0286	COG1011	Hydrolase
B565_0290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B565_0291	COG3028	Belongs to the UPF0307 family
B565_0292	COG0312	modulator of DNA gyrase
B565_0293	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B565_0294	COG5007	Belongs to the BolA IbaG family
B565_0296	COG2854	intermembrane phospholipid transfer
B565_0297	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B565_0298	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B565_0299	COG1127	ABC transporter
B565_0300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B565_0300	COG0517	IMP dehydrogenase activity
B565_0301	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B565_0302	COG3117	lipopolysaccharide transmembrane transporter activity
B565_0303	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B565_0304	COG1137	ATPase activity
B565_0307	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0308	COG1660	Displays ATPase and GTPase activities
B565_0309	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0310	COG3711	transcriptional antiterminator
B565_0310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0313	COG3964	amidohydrolase
B565_0319	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B565_0320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B565_0322	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B565_0323	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B565_0324	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B565_0325	COG0723	plastoquinol--plastocyanin reductase activity
B565_0326	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B565_0327	COG2857	Cytochrome c1
B565_0328	COG0625	glutathione transferase activity
B565_0329	COG2969	positive regulation of protein catabolic process
B565_0330	COG2823	Periplasmic or secreted lipoprotein
B565_0331	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B565_0332	COG0792	nuclease activity
B565_0333	COG3107	peptidoglycan biosynthetic process
B565_0334	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B565_0336	COG2001	Belongs to the MraZ family
B565_0337	COG0275	rRNA processing
B565_0338	COG3116	cell division
B565_0339	COG0768	penicillin binding
B565_0341	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B565_0342	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B565_0343	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B565_0344	COG0772	Belongs to the SEDS family
B565_0345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B565_0346	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B565_0348	COG0849	cell division
B565_0349	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B565_0350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B565_0352	COG0653	protein targeting
B565_0353	COG0494	nUDIX hydrolase
B565_0354	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B565_0355	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B565_0358	COG1459	type II secretion system
B565_0359	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B565_0363	COG2186	Transcriptional regulator
B565_0364	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B565_0365	COG0508	dehydrogenase complex catalyzes the overall conversion of
B565_0366	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B565_0368	COG0840	transmembrane signaling receptor activity
B565_0369	COG1752	Esterase of the alpha-beta hydrolase superfamily
B565_0370	COG1049	propionate catabolic process, 2-methylcitrate cycle
B565_0371	COG2200	EAL domain
B565_0373	COG0523	cobalamin synthesis protein
B565_0374	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_0377	COG0477	Major facilitator Superfamily
B565_0380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B565_0381	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B565_0385	COG0165	Argininosuccinate lyase
B565_0386	COG0137	argininosuccinate synthase activity
B565_0388	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B565_0389	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B565_0391	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B565_0394	COG3706	GGDEF domain
B565_0395	COG0814	amino acid
B565_0396	COG3932	Exopolysaccharide synthesis, ExoD
B565_0398	COG3706	GGDEF domain
B565_0399	COG0004	ammonium transporteR
B565_0400	COG3133	Outer membrane lipoprotein
B565_0401	COG0456	acetyltransferase
B565_0406	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B565_0409	COG0494	nUDIX hydrolase
B565_0410	COG0628	permease
B565_0415	COG3284	Transcriptional regulator
B565_0417	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0417	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B565_0417	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B565_0418	COG1461	Dihydroxyacetone kinase
B565_0419	COG2376	Dihydroxyacetone kinase
B565_0420	COG2252	PERMEase
B565_0421	COG1278	Cold shock
B565_0423	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B565_0426	COG2197	response regulator
B565_0429	COG1462	curli production assembly transport component CsgG
B565_0433	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B565_0434	COG3706	GGDEF domain
B565_0435	COG3047	cAMP biosynthetic process
B565_0436	COG0840	transmembrane signaling receptor activity
B565_0442	COG3135	benzoate transporter
B565_0443	COG1396	sequence-specific DNA binding
B565_0445	COG2926	Belongs to the UPF0265 family
B565_0447	COG0561	phosphatase activity
B565_0449	COG1058	Belongs to the CinA family
B565_0449	COG1546	Belongs to the CinA family
B565_0451	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B565_0453	COG1522	sequence-specific DNA binding
B565_0454	COG1368	sulfuric ester hydrolase activity
B565_0461	COG4221	oxidoreductase activity
B565_0464	COG1979	alcohol dehydrogenase
B565_0465	COG1803	Methylglyoxal synthase
B565_0469	COG1028	Short-chain dehydrogenase reductase Sdr
B565_0470	COG0784	Response regulator, receiver
B565_0470	COG0835	chemotaxis
B565_0472	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B565_0473	COG2949	membrane
B565_0474	COG3291	Pkd domain containing protein
B565_0475	COG3539	Fimbrial protein
B565_0477	COG3188	usher protein
B565_0478	COG3121	Chaperone
B565_0479	COG3539	Fimbrial protein
B565_0482	COG0318	PFAM AMP-dependent synthetase and ligase
B565_0483	COG1441	menaquinone biosynthetic process
B565_0484	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B565_0485	COG0596	Alpha beta hydrolase
B565_0486	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B565_0487	COG1169	isochorismate synthase
B565_0488	COG1575	Belongs to the MenA family. Type 1 subfamily
B565_0493	COG0513	Belongs to the DEAD box helicase family
B565_0494	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B565_0495	COG1988	membrane-bound metal-dependent
B565_0496	COG1671	Belongs to the UPF0178 family
B565_0500	COG0484	heat shock protein binding
B565_0502	COG3722	fumarate hydratase activity
B565_0503	COG0246	Mannitol dehydrogenase
B565_0504	COG2213	PTS system mannitol-specific
B565_0504	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0505	COG1560	Kdo2-lipid A biosynthetic process
B565_0506	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B565_0506	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B565_0507	COG1538	Outer membrane efflux protein
B565_0508	COG0494	nUDIX hydrolase
B565_0509	COG3151	Protein conserved in bacteria
B565_0511	COG3150	esterase
B565_0512	COG0187	DNA topoisomerase II activity
B565_0515	COG0583	DNA-binding transcription factor activity
B565_0517	COG3104	oligopeptide transport
B565_0523	COG2084	Dehydrogenase
B565_0525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B565_0529	COG0204	Acyl-transferase
B565_0530	COG1842	Phage shock protein A
B565_0533	COG2827	Endonuclease containing a URI domain
B565_0536	COG1573	uracil-dna glycosylase
B565_0537	COG0697	spore germination
B565_0538	COG0583	DNA-binding transcription factor activity
B565_0539	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B565_0540	COG1121	(ABC) transporter
B565_0541	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B565_0545	COG0739	heme binding
B565_0547	COG3068	Protein conserved in bacteria
B565_0551	COG0617	tRNA 3'-terminal CCA addition
B565_0553	COG1194	a g-specific adenine glycosylase
B565_0554	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B565_0556	COG3111	PFAM Bacterial OB fold (BOF) protein
B565_0557	COG3240	lipase activity
B565_0558	COG2885	chlorophyll binding
B565_0558	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B565_0559	COG3706	GGDEF domain
B565_0560	COG0557	exoribonuclease II activity
B565_0561	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B565_0563	COG2153	protein acetylation
B565_0564	COG0513	Belongs to the DEAD box helicase family
B565_0565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B565_0570	COG0735	belongs to the Fur family
B565_0571	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B565_0572	COG0840	transmembrane signaling receptor activity
B565_0574	COG4166	transmembrane transport
B565_0576	COG0110	maltose O-acetyltransferase activity
B565_0578	COG1024	Enoyl-CoA hydratase
B565_0581	COG4221	oxidoreductase activity
B565_0582	COG0442	prolyl-tRNA aminoacylation
B565_0583	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B565_0585	COG3008	intermembrane lipid transfer
B565_0585	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B565_0586	COG2995	paraquat-inducible protein a
B565_0588	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B565_0590	COG2203	Gaf domain
B565_0590	COG3706	GGDEF domain
B565_0590	COG4251	negative regulation of phosphorylation
B565_0590	COG5001	Diguanylate cyclase
B565_0591	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B565_0593	COG3916	Acyl-homoserine-lactone synthase
B565_0594	COG2771	luxR family
B565_0596	COG0840	transmembrane signaling receptor activity
B565_0597	COG0632	four-way junction helicase activity
B565_0598	COG2255	four-way junction helicase activity
B565_0600	COG1294	oxidase, subunit
B565_0601	COG4890	Cyd operon protein YbgT
B565_0602	COG3790	cyd operon protein YbgE
B565_0603	COG0824	Thioesterase
B565_0604	COG0811	peptide transport
B565_0607	COG0823	Involved in the tonB-independent uptake of proteins
B565_0608	COG2885	chlorophyll binding
B565_0609	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B565_0610	COG0733	neurotransmitter:sodium symporter activity
B565_0612	COG0733	neurotransmitter:sodium symporter activity
B565_0615	COG0561	phosphatase activity
B565_0618	COG1522	sequence-specific DNA binding
B565_0625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B565_0626	COG1640	4-alpha-glucanotransferase
B565_0627	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B565_0629	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B565_0630	COG0840	transmembrane signaling receptor activity
B565_0631	COG1585	Membrane protein implicated in regulation of membrane protease activity
B565_0632	COG0330	HflC and HflK could
B565_0633	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B565_0633	COG1648	precorrin-2 dehydrogenase activity
B565_0634	COG0175	sulfate reduction
B565_0635	COG2895	sulfate adenylyltransferase (ATP) activity
B565_0636	COG0471	metal ion transport
B565_0636	COG3273	potassium ion transport
B565_0637	COG0529	Catalyzes the synthesis of activated sulfate
B565_0640	COG0840	transmembrane signaling receptor activity
B565_0647	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B565_0650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B565_0651	COG3437	response regulator, receiver
B565_0651	COG0784	Response regulator, receiver
B565_0653	COG2076	Multidrug Resistance protein
B565_0654	COG2076	Multidrug Resistance protein
B565_0655	COG0346	lactoylglutathione lyase activity
B565_0656	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B565_0657	COG1643	Atp-dependent helicase
B565_0659	COG1489	DNA binding
B565_0660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B565_0661	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B565_0663	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B565_0664	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B565_0665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B565_0672	COG0842	Transport permease protein
B565_0673	COG1131	(ABC) transporter
B565_0676	COG0163	prenyltransferase activity
B565_0677	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B565_0678	COG0671	phosphoesterase, PA-phosphatase related
B565_0679	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B565_0681	COG1151	hydroxylamine reductase activity
B565_0682	COG0783	Belongs to the Dps family
B565_0683	COG3023	N-Acetylmuramoyl-L-alanine amidase
B565_0684	COG4807	Protein conserved in bacteria
B565_0686	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B565_0687	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B565_0688	COG3956	TIGRFAM MazG family protein
B565_0689	COG0504	CTP synthase activity
B565_0690	COG0148	phosphopyruvate hydratase activity
B565_0699	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B565_0701	COG0488	(ABC) transporter
B565_0705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B565_0708	COG1794	racemase activity, acting on amino acids and derivatives
B565_0710	COG2731	YhcH YjgK YiaL family protein
B565_0713	COG0668	transmembrane transport
B565_0714	COG1376	ErfK ybiS ycfS ynhG family protein
B565_0716	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B565_0717	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B565_0718	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B565_0720	COG0585	pseudouridine synthase activity
B565_0721	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B565_0722	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B565_0723	COG1238	metal cluster binding
B565_0726	COG1902	pentaerythritol trinitrate reductase activity
B565_0729	COG2957	Belongs to the agmatine deiminase family
B565_0730	COG0154	amidase activity
B565_0734	COG0513	Belongs to the DEAD box helicase family
B565_0735	COG2199	diguanylate cyclase activity
B565_0735	COG2203	Gaf domain
B565_0737	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
B565_0738	COG1858	cytochrome C peroxidase
B565_0743	COG2816	NAD+ diphosphatase activity
B565_0745	COG4191	Histidine kinase
B565_0750	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B565_0753	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B565_0754	COG4991	sh3 domain protein
B565_0756	COG2816	NAD+ diphosphatase activity
B565_0757	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B565_0758	COG1940	carbohydrate kinase activity
B565_0759	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B565_0760	COG0126	phosphoglycerate kinase activity
B565_0761	COG0191	fructose-bisphosphate aldolase activity
B565_0762	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_0767	COG1324	tolerance protein
B565_0771	COG0354	folic acid binding
B565_0772	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B565_0774	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B565_0776	COG1595	DNA-templated transcription, initiation
B565_0777	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
B565_0778	COG3026	antisigma factor binding
B565_0780	COG0481	GTPase activity
B565_0781	COG0681	Belongs to the peptidase S26 family
B565_0784	COG1381	Involved in DNA repair and RecF pathway recombination
B565_0785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B565_0787	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B565_0788	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_0789	COG3716	PTS system mannose fructose sorbose family IID component
B565_0791	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_0792	COG2222	sugar isomerase
B565_0794	COG1349	DNA-binding transcription factor activity
B565_0796	COG2350	Protein conserved in bacteria
B565_0797	COG2917	probably involved in intracellular septation
B565_0798	COG0076	glutamate decarboxylase activity
B565_0799	COG1272	protein, Hemolysin III
B565_0800	COG0569	domain protein
B565_0800	COG2985	domain, Protein
B565_0804	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B565_0809	COG2313	pseudouridylate synthase activity
B565_0810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B565_0817	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B565_0818	COG1765	OsmC-like protein
B565_0821	COG3954	Phosphoribulokinase
B565_0822	COG3089	Belongs to the UPF0270 family
B565_0823	COG3706	GGDEF domain
B565_0823	COG4251	negative regulation of phosphorylation
B565_0823	COG2203	Gaf domain
B565_0823	COG5001	Diguanylate cyclase
B565_0824	COG0429	hydrolase of the alpha beta-hydrolase fold
B565_0825	COG0784	Response regulator, receiver
B565_0825	COG0835	chemotaxis
B565_0827	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B565_0828	COG1047	Peptidyl-prolyl cis-trans
B565_0830	COG0305	Participates in initiation and elongation during chromosome replication
B565_0832	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B565_0833	COG0432	Pfam Uncharacterised protein family UPF0047
B565_0837	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B565_0839	COG3721	Heme iron utilization protein
B565_0840	COG0748	coenzyme F420 binding
B565_0845	COG2814	Major facilitator Superfamily
B565_0847	COG3655	Transcriptional regulator
B565_0849	COG0784	Response regulator, receiver
B565_0849	COG2205	protein histidine kinase activity
B565_0849	COG5002	protein histidine kinase activity
B565_0851	COG3706	GGDEF domain
B565_0854	COG3397	chitin binding
B565_0858	COG0835	chemotaxis
B565_0858	COG0784	Response regulator, receiver
B565_0859	COG2755	lipolytic protein G-D-S-L family
B565_0860	COG4181	ATPase activity
B565_0861	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B565_0862	COG1090	epimerase
B565_0863	COG2200	EAL domain
B565_0864	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B565_0866	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B565_0867	COG3171	Protein conserved in bacteria
B565_0868	COG2066	Belongs to the glutaminase family
B565_0869	COG2897	thiosulfate sulfurtransferase activity
B565_0872	COG0521	Mo-molybdopterin cofactor biosynthetic process
B565_0874	COG2966	Psort location CytoplasmicMembrane, score
B565_0875	COG3610	response to peptide
B565_0877	COG0175	sulfate reduction
B565_0878	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B565_0879	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B565_0881	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B565_0882	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B565_0884	COG0786	glutamate:sodium symporter activity
B565_0885	COG0252	asparaginase activity
B565_0886	COG3139	Protein of unknown function (DUF1315)
B565_0890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B565_0891	COG0321	lipoyl(octanoyl) transferase activity
B565_0892	COG2921	Belongs to the UPF0250 family
B565_0893	COG1686	Belongs to the peptidase S11 family
B565_0894	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B565_0895	COG2951	lytic endotransglycosylase activity
B565_0896	COG0772	Belongs to the SEDS family
B565_0897	COG0768	penicillin binding
B565_0898	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B565_0899	COG0799	negative regulation of ribosome biogenesis
B565_0900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B565_0903	COG0495	leucyl-tRNA aminoacylation
B565_0904	COG2888	peptidyl-tyrosine sulfation
B565_0905	COG0312	modulator of DNA gyrase
B565_0907	COG0716	FMN binding
B565_0908	COG4974	Belongs to the 'phage' integrase family
B565_0909	COG3706	GGDEF domain
B565_0909	COG0745	RESPONSE REGULATOR receiver
B565_0910	COG1970	mechanosensitive ion channel activity
B565_0913	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B565_0914	COG4535	Mg2 and Co2 transporter CorC
B565_0915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B565_0916	COG1702	phosphate starvation-inducible protein PhoH
B565_0917	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B565_0918	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B565_0919	COG1335	isochorismatase
B565_0920	COG3706	GGDEF domain
B565_0921	COG0583	DNA-binding transcription factor activity
B565_0926	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B565_0928	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B565_0930	COG0516	GMP reductase activity
B565_0932	COG0642	Histidine kinase
B565_0933	COG0745	RESPONSE REGULATOR receiver
B565_0935	COG1028	Short-chain dehydrogenase reductase Sdr
B565_0937	COG1022	Amp-dependent synthetase and ligase
B565_0940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_0943	COG3214	Protein conserved in bacteria
B565_0945	COG2195	Cleaves the N-terminal amino acid of tripeptides
B565_0946	COG0700	Nucleoside recognition
B565_0947	COG3366	ferrous iron transmembrane transporter activity
B565_0948	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B565_0949	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B565_0950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B565_0951	COG1053	succinate dehydrogenase
B565_0953	COG0584	glycerophosphoryl diester phosphodiesterase
B565_0954	COG3264	Mechanosensitive ion channel
B565_0954	COG1511	domain protein
B565_0956	COG0739	heme binding
B565_0958	COG0583	DNA-binding transcription factor activity
B565_0962	COG0583	DNA-binding transcription factor activity
B565_0963	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B565_0969	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B565_0970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B565_0972	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B565_0974	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B565_0976	COG0180	Tryptophanyl-tRNA synthetase
B565_0978	COG0512	Glutamine amidotransferase of anthranilate synthase
B565_0979	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B565_0981	COG1012	belongs to the aldehyde dehydrogenase family
B565_0984	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B565_0986	COG1013	pyruvate-flavodoxin oxidoreductase activity
B565_0986	COG0674	pyruvate-flavodoxin oxidoreductase activity
B565_0986	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B565_0986	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_0987	COG0366	Alpha amylase catalytic
B565_0992	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B565_0994	COG0490	domain, Protein
B565_0994	COG0471	metal ion transport
B565_0995	COG0012	GTP binding
B565_0996	COG0193	aminoacyl-tRNA hydrolase activity
B565_0997	COG0737	Belongs to the 5'-nucleotidase family
B565_0998	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B565_0999	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B565_1000	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B565_1001	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B565_1002	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B565_1003	COG2890	protein-(glutamine-N5) methyltransferase activity
B565_1005	COG2912	Transglutaminase-like superfamily
B565_1006	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B565_1007	COG1301	dicarboxylic acid transport
B565_1010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B565_1012	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B565_1012	COG3408	Glycogen debranching enzyme
B565_1014	COG1881	PFAM PEBP family protein
B565_1018	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B565_1020	COG0583	DNA-binding transcription factor activity
B565_1021	COG1028	Short-chain dehydrogenase reductase Sdr
B565_1022	COG0616	signal peptide processing
B565_1023	COG2211	Major facilitator Superfamily
B565_1024	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B565_1026	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B565_1028	COG2203	Gaf domain
B565_1028	COG2200	EAL domain
B565_1028	COG2199	diguanylate cyclase activity
B565_1034	COG2197	response regulator
B565_1037	COG3724	N-succinylarginine dihydrolase activity
B565_1038	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B565_1041	COG0840	transmembrane signaling receptor activity
B565_1043	COG2971	BadF BadG BcrA BcrD
B565_1045	COG4608	Belongs to the ABC transporter superfamily
B565_1046	COG0444	Belongs to the ABC transporter superfamily
B565_1047	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B565_1050	COG0784	Response regulator, receiver
B565_1050	COG2205	protein histidine kinase activity
B565_1054	COG3220	belongs to the UPF0276 family
B565_1060	COG1289	transmembrane transporter activity
B565_1061	COG0303	'Molybdopterin
B565_1062	COG0746	molybdenum cofactor guanylyltransferase activity
B565_1064	COG4662	Binding-protein-dependent transport system inner membrane component
B565_1067	COG3852	Histidine kinase
B565_1069	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B565_1077	COG3383	formate dehydrogenase (NAD+) activity
B565_1077	COG3383	formate dehydrogenase (NAD+) activity
B565_1078	COG0437	4 iron, 4 sulfur cluster binding
B565_1082	COG0281	malic enzyme
B565_1086	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_1092	COG0837	glucose binding
B565_1093	COG1737	Transcriptional regulator
B565_1094	COG0469	pyruvate kinase activity
B565_1098	COG1677	Flagellar hook-basal body complex protein FliE
B565_1100	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B565_1110	COG1987	bacterial-type flagellum assembly
B565_1111	COG1684	flagellar biosynthetic protein fliR
B565_1113	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B565_1115	COG0455	bacterial-type flagellum organization
B565_1118	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B565_1119	COG0643	Histidine kinase
B565_1119	COG2198	Histidine kinase
B565_1120	COG2201	protein-glutamate methylesterase activity
B565_1121	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B565_1122	COG1360	Flagellar Motor Protein
B565_1123	COG1192	Involved in chromosome partitioning
B565_1125	COG0835	chemotaxis
B565_1128	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B565_1129	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B565_1130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B565_1131	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B565_1132	COG1138	Cytochrome C-type biogenesis protein
B565_1133	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B565_1134	COG3088	subunit of a heme lyase
B565_1134	COG4235	cytochrome complex assembly
B565_1136	COG2853	Lipoprotein
B565_1138	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B565_1139	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B565_1141	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B565_1142	COG1882	Formate acetyltransferase
B565_1144	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B565_1144	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B565_1150	COG0259	pyridoxamine-phosphate oxidase activity
B565_1155	COG2850	peptidyl-arginine hydroxylation
B565_1156	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B565_1157	COG2915	High frequency lysogenization protein hflD homolog
B565_1158	COG0482	sulfurtransferase activity
B565_1160	COG1187	pseudouridine synthase activity
B565_1162	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_1163	COG2271	Major facilitator Superfamily
B565_1164	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_1164	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_1164	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_1169	COG0783	Belongs to the Dps family
B565_1174	COG0456	acetyltransferase
B565_1177	COG1609	Transcriptional regulator
B565_1178	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_1178	COG1263	PTS System
B565_1179	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B565_1180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B565_1182	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_1183	COG1960	acyl-CoA dehydrogenase activity
B565_1185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B565_1186	COG3383	formate dehydrogenase (NAD+) activity
B565_1189	COG2205	protein histidine kinase activity
B565_1189	COG0784	Response regulator, receiver
B565_1190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B565_1191	COG2867	negative regulation of translational initiation
B565_1193	COG1473	amidohydrolase
B565_1194	COG1960	acyl-CoA dehydrogenase activity
B565_1195	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B565_1196	COG0121	glutamine amidotransferase
B565_1200	COG0784	Response regulator, receiver
B565_1200	COG2205	protein histidine kinase activity
B565_1202	COG2197	response regulator
B565_1203	COG3850	Histidine kinase
B565_1204	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B565_1205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B565_1207	COG0243	molybdopterin cofactor binding
B565_1208	COG0437	4 iron, 4 sulfur cluster binding
B565_1209	COG0348	domain, Protein
B565_1211	COG3005	denitrification pathway
B565_1212	COG0521	Mo-molybdopterin cofactor biosynthetic process
B565_1213	COG0315	cyclic pyranopterin monophosphate synthase activity
B565_1214	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B565_1215	COG0314	molybdopterin synthase activity
B565_1218	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B565_1219	COG2267	carboxylic ester hydrolase activity
B565_1220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B565_1222	COG0302	gtp cyclohydrolase
B565_1223	COG0840	transmembrane signaling receptor activity
B565_1224	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B565_1226	COG0583	DNA-binding transcription factor activity
B565_1227	COG2353	YceI-like domain
B565_1229	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B565_1232	COG2195	Cleaves the N-terminal amino acid of tripeptides
B565_1233	COG1166	arginine decarboxylase activity
B565_1235	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B565_1239	COG0814	amino acid
B565_1241	COG3681	Belongs to the UPF0597 family
B565_1242	COG2964	Protein conserved in bacteria
B565_1244	COG2932	Transcriptional regulator
B565_1265	COG0640	Transcriptional regulator
B565_1267	COG4373	Mu-like prophage FluMu protein gp28
B565_1268	COG4383	Mu-like prophage protein gp29
B565_1273	COG4388	Caudovirus prohead serine protease
B565_1274	COG4397	Mu-like prophage major head subunit gpT
B565_1289	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B565_1290	COG0436	Aminotransferase
B565_1292	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B565_1293	COG1196	nuclear chromosome segregation
B565_1293	COG0741	lytic transglycosylase activity
B565_1293	COG0739	heme binding
B565_1296	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B565_1298	COG0788	formyltetrahydrofolate deformylase activity
B565_1299	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B565_1301	COG3118	belongs to the thioredoxin family
B565_1303	COG0791	NLP P60 protein
B565_1304	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B565_1306	COG0471	metal ion transport
B565_1308	COG1388	LysM domain
B565_1308	COG1376	ErfK ybiS ycfS ynhG family protein
B565_1309	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_1310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_1311	COG0745	RESPONSE REGULATOR receiver
B565_1312	COG5000	phosphorelay sensor kinase activity
B565_1312	COG5002	protein histidine kinase activity
B565_1317	COG1388	LysM domain
B565_1317	COG0741	lytic transglycosylase activity
B565_1318	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B565_1319	COG2226	methyltransferase
B565_1320	COG0328	RNA-DNA hybrid ribonuclease activity
B565_1321	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B565_1323	COG0784	Response regulator, receiver
B565_1323	COG3437	response regulator, receiver
B565_1324	COG2375	cellular response to nickel ion
B565_1325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B565_1326	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B565_1327	COG1120	ATPase activity
B565_1330	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_1331	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_1338	COG0708	Exodeoxyribonuclease III
B565_1344	COG3132	Protein of unknown function, DUF480
B565_1345	COG5001	Diguanylate cyclase
B565_1345	COG3300	MHYT domain
B565_1347	COG2841	Protein conserved in bacteria
B565_1349	COG0534	Mate efflux family protein
B565_1355	COG1309	transcriptional regulator
B565_1362	COG3152	Membrane
B565_1365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_1368	COG2207	Transcriptional regulator
B565_1369	COG0538	isocitrate dehydrogenase activity
B565_1371	COG3048	D-serine ammonia-lyase activity
B565_1372	COG2610	gluconate transmembrane transporter activity
B565_1373	COG0583	DNA-binding transcription factor activity
B565_1375	COG0791	NLP P60 protein
B565_1376	COG0583	DNA-binding transcription factor activity
B565_1377	COG0450	alkyl hydroperoxide reductase
B565_1381	COG0500	methyltransferase
B565_1382	COG4106	trans-aconitate 2-methyltransferase activity
B565_1383	COG1801	Protein of unknown function DUF72
B565_1385	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B565_1386	COG0217	transcriptional regulatory protein
B565_1387	COG1012	belongs to the aldehyde dehydrogenase family
B565_1387	COG1454	alcohol dehydrogenase
B565_1388	COG2095	MarC family integral membrane protein
B565_1390	COG0601	transmembrane transport
B565_1391	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B565_1392	COG0444	Belongs to the ABC transporter superfamily
B565_1394	COG0861	Integral membrane protein TerC family
B565_1395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B565_1402	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
B565_1404	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B565_1405	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B565_1406	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B565_1407	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B565_1408	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B565_1411	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B565_1412	COG0505	Belongs to the CarA family
B565_1413	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B565_1415	COG1605	Chorismate mutase
B565_1415	COG0287	Prephenate dehydrogenase
B565_1416	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B565_1418	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B565_1419	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B565_1426	COG0537	adenosine 5'-monophosphoramidase activity
B565_1429	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B565_1431	COG1301	dicarboxylic acid transport
B565_1435	COG2354	Protein conserved in bacteria
B565_1437	COG2233	PERMEase
B565_1439	COG1252	NADH dehydrogenase
B565_1441	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B565_1442	COG5001	Diguanylate cyclase
B565_1442	COG3300	MHYT domain
B565_1443	COG0446	pyridine nucleotide-disulphide oxidoreductase
B565_1445	COG2373	Large extracellular alpha-helical protein
B565_1446	COG4953	penicillin-binding protein 1C
B565_1449	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B565_1449	COG0301	tRNA thio-modification
B565_1452	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B565_1453	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B565_1454	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B565_1465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B565_1469	COG0483	inositol monophosphate 1-phosphatase activity
B565_1471	COG0625	glutathione transferase activity
B565_1472	COG2814	Major facilitator Superfamily
B565_1475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B565_1476	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B565_1477	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B565_1478	COG0509	glycine decarboxylation via glycine cleavage system
B565_1479	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B565_1479	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B565_1480	COG0840	transmembrane signaling receptor activity
B565_1485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B565_1486	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B565_1486	COG0574	Belongs to the PEP-utilizing enzyme family
B565_1491	COG1464	Belongs to the NlpA lipoprotein family
B565_1492	COG3083	sulfuric ester hydrolase activity
B565_1493	COG3082	Protein of unknown function (DUF1414)
B565_1494	COG3081	Nucleoid-associated protein
B565_1496	COG1175	transmembrane transport
B565_1498	COG3842	ATPase activity
B565_1504	COG4783	chaperone-mediated protein folding
B565_1506	COG1393	Belongs to the ArsC family
B565_1508	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
B565_1509	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_1510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B565_1511	COG2431	L-lysine efflux transmembrane transporter activity
B565_1513	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_1514	COG4215	(ABC) transporter
B565_1515	COG4160	amino acid transport
B565_1516	COG0564	pseudouridine synthase activity
B565_1519	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B565_1521	COG0625	glutathione transferase activity
B565_1523	COG2195	Cleaves the N-terminal amino acid of tripeptides
B565_1524	COG3069	C4-dicarboxylate transmembrane transporter activity
B565_1535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B565_1537	COG1091	dTDP-4-dehydrorhamnose reductase activity
B565_1542	COG0367	asparagine synthase
B565_1544	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B565_1544	COG4651	solute:proton antiporter activity
B565_1545	COG0647	UMP catabolic process
B565_1546	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B565_1548	COG1902	pentaerythritol trinitrate reductase activity
B565_1549	COG1253	flavin adenine dinucleotide binding
B565_1551	COG0277	FAD linked oxidase domain protein
B565_1551	COG0247	lactate metabolic process
B565_1553	COG2050	protein possibly involved in aromatic compounds catabolism
B565_1555	COG2056	Na+-H+ antiporter family
B565_1556	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B565_1557	COG0671	phosphoesterase, PA-phosphatase related
B565_1558	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B565_1559	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B565_1561	COG0101	tRNA pseudouridine synthase activity
B565_1562	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B565_1563	COG0285	dihydrofolate synthase activity
B565_1564	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B565_1565	COG0393	Putative heavy-metal-binding
B565_1568	COG1648	precorrin-2 dehydrogenase activity
B565_1568	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B565_1569	COG2221	Nitrite and sulphite reductase 4Fe-4S
B565_1572	COG4667	esterase of the alpha-beta hydrolase superfamily
B565_1573	COG1619	proteins homologs of microcin C7 resistance protein MccF
B565_1574	COG1368	sulfuric ester hydrolase activity
B565_1576	COG0527	aspartate kinase activity
B565_1577	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B565_1577	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B565_1578	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B565_1582	COG0596	Alpha beta hydrolase
B565_1586	COG1136	(ABC) transporter
B565_1589	COG2814	Major facilitator Superfamily
B565_1592	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
B565_1593	COG0672	)-iron permease
B565_1600	COG0659	secondary active sulfate transmembrane transporter activity
B565_1601	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B565_1602	COG0326	Molecular chaperone. Has ATPase activity
B565_1603	COG4172	Belongs to the ABC transporter superfamily
B565_1604	COG4172	Belongs to the ABC transporter superfamily
B565_1605	COG4171	peptide transport system, permease
B565_1606	COG4168	peptide transport system, permease
B565_1608	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B565_1609	COG1842	Phage shock protein A
B565_1612	COG3106	COG3106 Predicted ATPase
B565_1613	COG3768	UPF0283 membrane protein
B565_1614	COG0583	DNA-binding transcription factor activity
B565_1615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B565_1616	COG3842	ATPase activity
B565_1617	COG1176	ABC-type spermidine putrescine transport system, permease component I
B565_1618	COG1177	transmembrane transport
B565_1619	COG1012	belongs to the aldehyde dehydrogenase family
B565_1621	COG2154	pterin-4-alpha-carbinolamine dehydratase
B565_1624	COG2199	diguanylate cyclase activity
B565_1625	COG2885	chlorophyll binding
B565_1626	COG0861	Integral membrane protein TerC family
B565_1632	COG2910	NAD(P)H-binding
B565_1633	COG0583	DNA-binding transcription factor activity
B565_1634	COG0583	DNA-binding transcription factor activity
B565_1637	COG1335	isochorismatase
B565_1639	COG0583	DNA-binding transcription factor activity
B565_1640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B565_1642	COG0583	DNA-binding transcription factor activity
B565_1643	COG2723	6-phospho-beta-galactosidase activity
B565_1644	COG1944	ATP diphosphatase activity
B565_1646	COG2116	formate transmembrane transporter activity
B565_1647	COG1882	Formate acetyltransferase
B565_1648	COG2983	Belongs to the UPF0260 family
B565_1652	COG0058	SHG alpha-glucan phosphorylase activity
B565_1653	COG0471	metal ion transport
B565_1654	COG3118	belongs to the thioredoxin family
B565_1657	COG1132	(ABC) transporter
B565_1658	COG1132	(ABC) transporter
B565_1660	COG2501	S4 domain
B565_1663	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B565_1671	COG2009	succinate dehydrogenase
B565_1672	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B565_1673	COG1053	succinate dehydrogenase
B565_1675	COG0567	Dehydrogenase, E1 component
B565_1676	COG0508	dehydrogenase complex catalyzes the overall conversion of
B565_1677	COG0045	succinate-CoA ligase (ADP-forming) activity
B565_1680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_1682	COG3842	ATPase activity
B565_1683	COG1840	ABC-type Fe3 transport system, periplasmic component
B565_1685	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B565_1687	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B565_1690	COG4235	cytochrome complex assembly
B565_1690	COG3088	subunit of a heme lyase
B565_1692	COG1138	Cytochrome C-type biogenesis protein
B565_1693	COG3301	Polysulphide reductase, NrfD
B565_1694	COG0437	4 iron, 4 sulfur cluster binding
B565_1695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B565_1698	COG0247	lactate metabolic process
B565_1699	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
B565_1700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B565_1701	COG3012	SEC-C Motif Domain Protein
B565_1702	COG0840	transmembrane signaling receptor activity
B565_1703	COG1940	carbohydrate kinase activity
B565_1703	COG1846	Transcriptional regulator
B565_1705	COG0730	response to heat
B565_1706	COG0583	DNA-binding transcription factor activity
B565_1709	COG3593	DNA synthesis involved in DNA repair
B565_1712	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B565_1713	COG1011	Hydrolase
B565_1716	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B565_1717	COG2832	Protein of unknown function (DUF454)
B565_1718	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B565_1720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B565_1722	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B565_1725	COG1560	Kdo2-lipid A biosynthetic process
B565_1726	COG1560	Kdo2-lipid A biosynthetic process
B565_1729	COG2199	diguanylate cyclase activity
B565_1729	COG2203	Gaf domain
B565_1731	COG0417	DNA replication proofreading
B565_1734	COG1451	nucleotide metabolic process
B565_1737	COG3069	C4-dicarboxylate transmembrane transporter activity
B565_1740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B565_1740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_1741	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B565_1743	COG2985	domain, Protein
B565_1743	COG0569	domain protein
B565_1745	COG0556	nucleotide-excision repair
B565_1747	COG0586	Pfam SNARE associated Golgi protein
B565_1748	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B565_1749	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B565_1752	COG4681	YaeQ
B565_1754	COG2932	Transcriptional regulator
B565_1775	COG0640	Transcriptional regulator
B565_1777	COG4373	Mu-like prophage FluMu protein gp28
B565_1778	COG4383	Mu-like prophage protein gp29
B565_1783	COG4388	Caudovirus prohead serine protease
B565_1784	COG4397	Mu-like prophage major head subunit gpT
B565_1791	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B565_1804	COG0534	Mate efflux family protein
B565_1807	COG0307	riboflavin synthase, alpha
B565_1809	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B565_1810	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B565_1811	COG0697	spore germination
B565_1812	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B565_1820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B565_1822	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B565_1823	COG2894	cell division
B565_1824	COG0850	regulation of cytokinetic process
B565_1825	COG3100	YcgL domain-containing protein
B565_1828	COG1760	l-serine dehydratase
B565_1830	COG1760	l-serine dehydratase
B565_1831	COG3123	guanosine phosphorylase activity
B565_1833	COG0205	6-phosphofructokinase activity
B565_1835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B565_1836	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B565_1838	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B565_1839	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B565_1840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B565_1847	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B565_1848	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B565_1849	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B565_1851	COG0549	Belongs to the carbamate kinase family
B565_1852	COG0697	spore germination
B565_1853	COG3608	succinylglutamate desuccinylase aspartoacylase
B565_1853	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B565_1855	COG2068	MobA-Related Protein
B565_1856	COG0493	'glutamate synthase
B565_1856	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B565_1857	COG0402	S-adenosylhomocysteine deaminase activity
B565_1858	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B565_1859	COG2080	2 iron, 2 sulfur cluster binding
B565_1859	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B565_1860	COG2233	PERMEase
B565_1861	COG0402	S-adenosylhomocysteine deaminase activity
B565_1862	COG2252	PERMEase
B565_1863	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B565_1864	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B565_1865	COG2080	2 iron, 2 sulfur cluster binding
B565_1868	COG3134	Outer membrane lipoprotein
B565_1871	COG0318	PFAM AMP-dependent synthetase and ligase
B565_1872	COG3706	GGDEF domain
B565_1875	COG0107	imidazoleglycerol-phosphate synthase activity
B565_1876	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B565_1877	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B565_1878	COG0131	Imidazoleglycerol-phosphate dehydratase
B565_1878	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B565_1879	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B565_1880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B565_1881	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B565_1883	COG1199	ATP-dependent helicase activity
B565_1884	COG1214	PFAM Peptidase M22, glycoprotease
B565_1886	COG2267	carboxylic ester hydrolase activity
B565_1887	COG0318	PFAM AMP-dependent synthetase and ligase
B565_1889	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B565_1890	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B565_1891	COG0709	Synthesizes selenophosphate from selenide and ATP
B565_1894	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B565_1895	COG0840	transmembrane signaling receptor activity
B565_1896	COG1254	Belongs to the acylphosphatase family
B565_1898	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B565_1898	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B565_1899	COG0489	protein tyrosine kinase activity
B565_1900	COG0572	uridine kinase
B565_1901	COG0717	Belongs to the dCTP deaminase family
B565_1902	COG0306	phosphate transporter
B565_1903	COG3313	Fe-S protein
B565_1904	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B565_1905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B565_1906	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B565_1907	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B565_1909	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B565_1911	COG0366	Alpha amylase catalytic
B565_1914	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B565_1915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B565_1916	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B565_1917	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B565_1918	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B565_1919	COG0072	phenylalanine-tRNA ligase activity
B565_1919	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B565_1920	COG0776	regulation of translation
B565_1921	COG2205	protein histidine kinase activity
B565_1921	COG0784	Response regulator, receiver
B565_1924	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B565_1926	COG3300	MHYT domain
B565_1926	COG5001	Diguanylate cyclase
B565_1927	COG1609	Transcriptional regulator
B565_1928	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B565_1929	COG1879	ABC-type sugar transport system periplasmic component
B565_1930	COG1172	Belongs to the binding-protein-dependent transport system permease family
B565_1931	COG1129	ABC transporter
B565_1932	COG1869	D-ribose catabolic process
B565_1933	COG0625	glutathione transferase activity
B565_1935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B565_1936	COG1177	transmembrane transport
B565_1937	COG1176	ABC-type spermidine putrescine transport system, permease component I
B565_1941	COG0037	tRNA processing
B565_1942	COG0589	response to stress
B565_1943	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B565_1946	COG2217	Heavy metal translocating P-type atpase
B565_1948	COG2010	Cytochrome c
B565_1951	COG3278	Belongs to the heme-copper respiratory oxidase family
B565_1953	COG1956	GAF domain-containing protein
B565_1954	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B565_1956	COG0308	aminopeptidase N
B565_1958	COG2902	Dehydrogenase
B565_1959	COG0167	dihydroorotate dehydrogenase activity
B565_1961	COG0254	rRNA binding
B565_1962	COG0116	Belongs to the methyltransferase superfamily
B565_1962	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B565_1964	COG0488	(ABC) transporter
B565_1966	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B565_1967	COG1067	ATP-dependent peptidase activity
B565_1971	COG3141	response to X-ray
B565_1972	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B565_1973	COG4221	oxidoreductase activity
B565_1982	COG0372	Belongs to the citrate synthase family
B565_1983	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B565_1985	COG2995	paraquat-inducible protein a
B565_1986	COG3008	intermembrane lipid transfer
B565_1987	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B565_1987	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B565_1991	COG0084	hydrolase, TatD family'
B565_1992	COG0470	DNA polymerase III
B565_1993	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B565_1994	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B565_1995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B565_1996	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B565_1997	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B565_1998	COG1028	Short-chain dehydrogenase reductase Sdr
B565_2000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B565_2001	COG0416	fatty acid biosynthetic process
B565_2002	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B565_2003	COG1399	metal-binding, possibly nucleic acid-binding protein
B565_2004	COG0424	maF-like protein
B565_2007	COG1530	ribonuclease E activity
B565_2008	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B565_2008	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_2008	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_2009	COG1105	Belongs to the carbohydrate kinase PfkB family
B565_2010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_2010	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_2012	COG1609	Transcriptional regulator
B565_2013	COG0814	amino acid
B565_2015	COG3788	relative of glutathione S-transferase, MAPEG superfamily
B565_2017	COG0513	Belongs to the DEAD box helicase family
B565_2019	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B565_2020	COG2890	protein-(glutamine-N5) methyltransferase activity
B565_2021	COG2840	Smr protein MutS2
B565_2022	COG3706	GGDEF domain
B565_2026	COG2824	Alkylphosphonate utilization operon protein PhnA
B565_2029	COG0494	nUDIX hydrolase
B565_2030	COG0814	amino acid
B565_2032	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B565_2033	COG0514	ATP-dependent DNA helicase (RecQ)
B565_2034	COG2766	serine protein kinase
B565_2035	COG2718	Belongs to the UPF0229 family
B565_2036	COG2719	SpoVR family
B565_2037	COG1250	3-hydroxyacyl-CoA dehydrogenase
B565_2037	COG1024	Enoyl-CoA hydratase
B565_2038	COG0183	Belongs to the thiolase family
B565_2039	COG0714	Associated with various cellular activities
B565_2043	COG2304	oxidoreductase activity
B565_2045	COG1595	DNA-templated transcription, initiation
B565_2048	COG2067	long-chain fatty acid transport protein
B565_2049	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B565_2052	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B565_2054	COG1643	Atp-dependent helicase
B565_2056	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B565_2058	COG3119	arylsulfatase activity
B565_2059	COG0714	Associated with various cellular activities
B565_2062	COG2304	oxidoreductase activity
B565_2063	COG2304	oxidoreductase activity
B565_2068	COG0641	radical SAM
B565_2070	COG5001	Diguanylate cyclase
B565_2075	COG0840	transmembrane signaling receptor activity
B565_2087	COG2925	Exonuclease
B565_2089	COG3345	alpha-galactosidase
B565_2090	COG1380	Effector of murein hydrolase LrgA
B565_2091	COG1346	cytolysis
B565_2092	COG0295	cytidine deaminase activity
B565_2093	COG3033	Beta-eliminating lyase
B565_2095	COG3046	protein related to deoxyribodipyrimidine photolyase
B565_2096	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_2098	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B565_2102	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B565_2104	COG0454	-acetyltransferase
B565_2105	COG3158	transport of potassium into the cell
B565_2107	COG0800	Aldolase
B565_2108	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B565_2110	COG1028	Short-chain dehydrogenase reductase Sdr
B565_2113	COG4821	SIS domain
B565_2114	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B565_2115	COG4821	SIS domain
B565_2117	COG3716	PTS system mannose fructose sorbose family IID component
B565_2118	COG3715	PTS system
B565_2119	COG2188	Transcriptional regulator
B565_2120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B565_2121	COG0651	ATP synthesis coupled electron transport
B565_2122	COG0650	Formate hydrogenlyase subunit 4
B565_2123	COG3261	NADH dehydrogenase
B565_2123	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B565_2124	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2125	COG3260	NADH ubiquinone oxidoreductase 20
B565_2127	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B565_2128	COG1921	L-seryl-tRNASec selenium transferase activity
B565_2130	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B565_2131	COG0298	carbon dioxide binding
B565_2133	COG0309	Hydrogenase expression formation protein (HypE)
B565_2134	COG0375	protein maturation
B565_2136	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B565_2137	COG3842	ATPase activity
B565_2138	COG0444	Belongs to the ABC transporter superfamily
B565_2139	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B565_2142	COG1773	rubredoxin
B565_2143	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B565_2144	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B565_2145	COG5557	Pfam Polysulphide reductase, NrfD
B565_2146	COG0437	4 iron, 4 sulfur cluster binding
B565_2147	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B565_2148	COG2203	Gaf domain
B565_2148	COG5001	Diguanylate cyclase
B565_2148	COG3706	GGDEF domain
B565_2148	COG4251	negative regulation of phosphorylation
B565_2149	COG0438	transferase activity, transferring glycosyl groups
B565_2150	COG0438	transferase activity, transferring glycosyl groups
B565_2154	COG0438	transferase activity, transferring glycosyl groups
B565_2162	COG0438	transferase activity, transferring glycosyl groups
B565_2163	COG1215	transferase activity, transferring glycosyl groups
B565_2164	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B565_2172	COG3850	Histidine kinase
B565_2172	COG2205	protein histidine kinase activity
B565_2172	COG4999	Histidine kinase
B565_2172	COG3437	response regulator, receiver
B565_2177	COG0730	response to heat
B565_2179	COG1028	Short-chain dehydrogenase reductase Sdr
B565_2181	COG1024	Enoyl-CoA hydratase
B565_2182	COG1024	Enoyl-CoA hydratase
B565_2183	COG1960	acyl-CoA dehydrogenase activity
B565_2184	COG1960	acyl-CoA dehydrogenase activity
B565_2185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B565_2186	COG1024	Enoyl-CoA hydratase
B565_2192	COG1584	GPR1 FUN34 yaaH family protein
B565_2195	COG1115	amino acid carrier protein
B565_2196	COG3385	transposase activity
B565_2205	COG2801	Transposase and inactivated derivatives
B565_2206	COG2963	transposase activity
B565_2207	COG4695	Portal protein
B565_2208	COG1024	Enoyl-CoA hydratase
B565_2211	COG3162	membrane
B565_2212	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B565_2213	COG0488	(ABC) transporter
B565_2214	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B565_2215	COG0776	regulation of translation
B565_2216	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B565_2217	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B565_2218	COG0740	serine-type endopeptidase activity
B565_2219	COG0544	peptidyl-prolyl cis-trans isomerase activity
B565_2221	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B565_2222	COG4591	ABC-type transport system involved in lipoprotein release permease component
B565_2223	COG1136	(ABC) transporter
B565_2224	COG4591	ABC-type transport system involved in lipoprotein release permease component
B565_2226	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B565_2227	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B565_2228	COG4166	transmembrane transport
B565_2229	COG0697	spore germination
B565_2231	COG2062	phosphohistidine phosphatase, SixA
B565_2232	COG1025	Belongs to the peptidase M16 family
B565_2238	COG0519	Catalyzes the synthesis of GMP from XMP
B565_2238	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B565_2239	COG0516	GMP reductase activity
B565_2239	COG0517	IMP dehydrogenase activity
B565_2240	COG3038	cytochrome b561
B565_2241	COG1570	exodeoxyribonuclease VII activity
B565_2242	COG2188	Transcriptional regulator
B565_2243	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_2243	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_2243	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B565_2244	COG0383	alpha-mannosidase activity
B565_2245	COG1181	Belongs to the D-alanine--D-alanine ligase family
B565_2247	COG0386	Belongs to the glutathione peroxidase family
B565_2248	COG0513	Belongs to the DEAD box helicase family
B565_2251	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B565_2252	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B565_2253	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B565_2258	COG0598	Magnesium transport protein CorA
B565_2264	COG5001	Diguanylate cyclase
B565_2264	COG3300	MHYT domain
B565_2267	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B565_2269	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B565_2270	COG0563	adenylate kinase activity
B565_2272	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B565_2273	COG1286	toxin biosynthetic process
B565_2274	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B565_2275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B565_2276	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B565_2277	COG1674	ftsk spoiiie
B565_2277	COG0531	amino acid
B565_2279	COG0686	Belongs to the AlaDH PNT family
B565_2280	COG0492	ferredoxin-NADP+ reductase activity
B565_2281	COG3706	GGDEF domain
B565_2282	COG3134	Outer membrane lipoprotein
B565_2283	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B565_2284	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B565_2285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B565_2286	COG0542	response to heat
B565_2287	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B565_2288	COG1278	Cold shock
B565_2289	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B565_2290	COG0745	RESPONSE REGULATOR receiver
B565_2291	COG2205	protein histidine kinase activity
B565_2293	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B565_2293	COG0392	lysyltransferase activity
B565_2297	COG1435	thymidine kinase activity
B565_2298	COG1757	Na H antiporter
B565_2299	COG2916	Histone family protein nucleoid-structuring protein H-NS
B565_2300	COG2096	Adenosyltransferase
B565_2301	COG3530	Putative quorum-sensing-regulated virulence factor
B565_2302	COG0602	queuosine metabolic process
B565_2303	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B565_2307	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B565_2309	COG0776	regulation of translation
B565_2310	COG0539	negative regulation of cytoplasmic translation
B565_2311	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B565_2312	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B565_2315	COG2814	Major facilitator Superfamily
B565_2319	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B565_2320	COG5001	Diguanylate cyclase
B565_2320	COG3300	MHYT domain
B565_2321	COG0583	DNA-binding transcription factor activity
B565_2322	COG3437	response regulator, receiver
B565_2327	COG4989	oxidoreductase activity
B565_2328	COG0724	RNA recognition motif
B565_2330	COG1126	abc transporter atp-binding protein
B565_2331	COG0765	amino acid transport
B565_2332	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_2333	COG4597	amino acid ABC transporter
B565_2334	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
B565_2336	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B565_2338	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B565_2339	COG1360	Flagellar Motor Protein
B565_2340	COG4771	TonB-dependent receptor
B565_2341	COG1770	oligopeptidase
B565_2345	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2346	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2347	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2347	COG0649	NAD binding
B565_2350	COG1034	ATP synthesis coupled electron transport
B565_2351	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B565_2352	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2353	COG0839	Belongs to the complex I subunit 6 family
B565_2354	COG0713	ATP synthesis coupled electron transport
B565_2356	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B565_2357	COG1007	ATP synthesis coupled electron transport
B565_2360	COG2199	diguanylate cyclase activity
B565_2360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B565_2361	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B565_2361	COG0047	phosphoribosylformylglycinamidine synthase activity
B565_2362	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B565_2363	COG1645	bacterial-type flagellum-dependent swarming motility
B565_2364	COG1160	GTP binding
B565_2365	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B565_2366	COG2976	Protein conserved in bacteria
B565_2367	COG0124	histidyl-tRNA synthetase
B565_2371	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B565_2372	COG0105	UTP biosynthetic process
B565_2375	COG0633	Ferredoxin
B565_2376	COG0443	Heat shock 70 kDa protein
B565_2377	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B565_2379	COG0822	iron-sulfur transferase activity
B565_2380	COG1104	cysteine desulfurase activity
B565_2389	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B565_2390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B565_2391	COG1862	Preprotein translocase
B565_2392	COG0343	queuine tRNA-ribosyltransferase activity
B565_2393	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B565_2394	COG0517	IMP dehydrogenase activity
B565_2395	COG0450	alkyl hydroperoxide reductase
B565_2396	COG3634	alkyl hydroperoxide reductase activity
B565_2405	COG1242	4 iron, 4 sulfur cluster binding
B565_2406	COG0067	glutamate synthase
B565_2406	COG0070	glutamate synthase
B565_2406	COG0069	glutamate synthase activity
B565_2407	COG0493	'glutamate synthase
B565_2409	COG0513	Belongs to the DEAD box helicase family
B565_2413	COG0023	Translation Initiation Factor
B565_2414	COG2119	membrane
B565_2422	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B565_2424	COG0215	cysteine-tRNA ligase activity
B565_2425	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B565_2427	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B565_2430	COG2261	transglycosylase associated protein
B565_2431	COG0642	Histidine kinase
B565_2437	COG4974	Belongs to the 'phage' integrase family
B565_2454	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B565_2457	COG4695	Portal protein
B565_2487	COG0322	excinuclease ABC activity
B565_2488	COG2197	response regulator
B565_2489	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B565_2490	COG2835	tetraacyldisaccharide 4'-kinase activity
B565_2491	COG1663	tetraacyldisaccharide 4'-kinase activity
B565_2493	COG2333	competence protein COMEC
B565_2493	COG0658	competence protein
B565_2496	COG1448	Aminotransferase
B565_2498	COG0583	DNA-binding transcription factor activity
B565_2499	COG3085	chromosome segregation
B565_2500	COG4574	serine-type endopeptidase inhibitor activity
B565_2501	COG0584	glycerophosphoryl diester phosphodiesterase
B565_2503	COG1349	DNA-binding transcription factor activity
B565_2504	COG2271	Major facilitator Superfamily
B565_2505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B565_2506	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B565_2507	COG0840	transmembrane signaling receptor activity
B565_2509	COG0583	DNA-binding transcription factor activity
B565_2512	COG0656	L-ascorbic acid biosynthetic process
B565_2514	COG2814	Major facilitator Superfamily
B565_2515	COG2249	NAD(P)H dehydrogenase (quinone) activity
B565_2518	COG3220	belongs to the UPF0276 family
B565_2522	COG1294	oxidase, subunit
B565_2524	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B565_2526	COG2979	Protein of unknown function (DUF533)
B565_2527	COG1607	acyl-coa hydrolase
B565_2529	COG0583	DNA-binding transcription factor activity
B565_2530	COG2807	transmembrane transport
B565_2531	COG1187	pseudouridine synthase activity
B565_2533	COG0346	lactoylglutathione lyase activity
B565_2539	COG4657	Part of a membrane complex involved in electron transport
B565_2540	COG2878	Part of a membrane complex involved in electron transport
B565_2542	COG4658	electron transport chain
B565_2543	COG4659	FMN binding
B565_2545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B565_2546	COG0346	lactoylglutathione lyase activity
B565_2551	COG2801	Transposase and inactivated derivatives
B565_2553	COG1199	ATP-dependent helicase activity
B565_2555	COG0123	including yeast histone deacetylase and acetoin utilization protein
B565_2556	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B565_2557	COG1785	Belongs to the alkaline phosphatase family
B565_2561	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B565_2562	COG2197	response regulator
B565_2564	COG2271	Major facilitator Superfamily
B565_2565	COG3706	GGDEF domain
B565_2566	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_2567	COG0765	amino acid transport
B565_2568	COG1126	abc transporter atp-binding protein
B565_2571	COG0531	amino acid
B565_2574	COG1253	flavin adenine dinucleotide binding
B565_2575	COG0704	Plays a role in the regulation of phosphate uptake
B565_2577	COG0581	inorganic phosphate transmembrane transporter activity
B565_2578	COG0573	inorganic phosphate transmembrane transporter activity
B565_2579	COG0590	tRNA wobble adenosine to inosine editing
B565_2580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B565_2584	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B565_2585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B565_2586	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B565_2587	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B565_2588	COG2204	response regulator
B565_2589	COG3852	Histidine kinase
B565_2590	COG2204	response regulator
B565_2592	COG2716	regulation of RNA biosynthetic process
B565_2593	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B565_2594	COG0248	Ppx GppA phosphatase
B565_2595	COG2239	Acts as a magnesium transporter
B565_2596	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B565_2599	COG1706	bacterial-type flagellum-dependent cell motility
B565_2600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B565_2601	COG4786	Flagellar basal body rod
B565_2602	COG4787	bacterial-type flagellum-dependent cell motility
B565_2605	COG1558	bacterial-type flagellum-dependent cell motility
B565_2606	COG1815	bacterial-type flagellum-dependent cell motility
B565_2607	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B565_2608	COG0784	Response regulator, receiver
B565_2608	COG0835	chemotaxis
B565_2609	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B565_2612	COG0622	Phosphoesterase
B565_2613	COG4166	transmembrane transport
B565_2615	COG1187	pseudouridine synthase activity
B565_2616	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B565_2618	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B565_2619	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B565_2621	COG1349	DNA-binding transcription factor activity
B565_2622	COG0697	spore germination
B565_2623	COG4166	transmembrane transport
B565_2628	COG1278	Cold shock
B565_2633	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B565_2633	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B565_2634	COG1028	Short-chain dehydrogenase reductase Sdr
B565_2635	COG3433	isochorismatase activity
B565_2635	COG1535	isochorismatase
B565_2636	COG1021	2,3-dihydroxybenzoate-AMP ligase
B565_2637	COG1169	isochorismate synthase
B565_2638	COG4771	TonB-dependent receptor
B565_2639	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B565_2641	COG0741	lytic transglycosylase activity
B565_2643	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B565_2645	COG2911	Protein conserved in bacteria
B565_2646	COG0729	surface antigen
B565_2648	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B565_2650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B565_2652	COG4134	Bacterial extracellular solute-binding protein
B565_2654	COG4136	ATPase activity
B565_2655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B565_2656	COG2951	lytic endotransglycosylase activity
B565_2657	COG1846	Transcriptional regulator
B565_2659	COG0033	Phosphoglucomutase
B565_2660	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B565_2661	COG0596	Alpha beta hydrolase
B565_2664	COG0716	FMN binding
B565_2666	COG0735	belongs to the Fur family
B565_2667	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B565_2669	COG2190	(PTS) system
B565_2669	COG1263	PTS System
B565_2669	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_2670	COG0363	glucosamine-6-phosphate deaminase activity
B565_2671	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B565_2672	COG1846	Transcriptional regulator
B565_2672	COG1940	carbohydrate kinase activity
B565_2673	COG2194	sulfuric ester hydrolase activity
B565_2674	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B565_2674	COG2199	diguanylate cyclase activity
B565_2675	COG3275	phosphorelay sensor kinase activity
B565_2676	COG3279	Response regulator of the LytR AlgR family
B565_2677	COG1966	Carbon starvation protein
B565_2679	COG1566	PFAM secretion protein HlyD family protein
B565_2680	COG1061	Type III restriction enzyme res subunit
B565_2681	COG2027	D-alanyl-D-alanine carboxypeptidase
B565_2682	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B565_2683	COG3021	interspecies interaction between organisms
B565_2685	COG1607	acyl-coa hydrolase
B565_2686	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B565_2688	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B565_2688	COG1013	pyruvate-flavodoxin oxidoreductase activity
B565_2688	COG0674	pyruvate-flavodoxin oxidoreductase activity
B565_2688	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B565_2691	COG3217	Mosc domain protein beta barrel domain protein
B565_2691	COG0633	Ferredoxin
B565_2691	COG3217	Mosc domain protein beta barrel domain protein
B565_2691	COG0633	Ferredoxin
B565_2693	COG0501	Belongs to the peptidase M48B family
B565_2694	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B565_2695	COG1073	alpha beta
B565_2695	COG2226	methyltransferase
B565_2696	COG0156	8-amino-7-oxononanoate synthase activity
B565_2697	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B565_2698	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B565_2701	COG0017	Asparaginyl-tRNA synthetase
B565_2703	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B565_2705	COG1473	amidohydrolase
B565_2706	COG3069	C4-dicarboxylate transmembrane transporter activity
B565_2708	COG1393	Belongs to the ArsC family
B565_2709	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B565_2710	COG1876	peptidase activity
B565_2711	COG3263	regulation of cellular component size
B565_2714	COG1280	lysine exporter protein (LysE YggA)
B565_2720	COG0564	pseudouridine synthase activity
B565_2722	COG1454	alcohol dehydrogenase
B565_2730	COG2894	cell division
B565_2732	COG4964	Belongs to the GSP D family
B565_2738	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B565_2739	COG0702	epimerase
B565_2741	COG0095	Lipoate-protein ligase
B565_2744	COG1136	(ABC) transporter
B565_2744	COG0577	efflux transmembrane transporter activity
B565_2745	COG1136	(ABC) transporter
B565_2745	COG0577	efflux transmembrane transporter activity
B565_2746	COG1136	(ABC) transporter
B565_2746	COG0577	efflux transmembrane transporter activity
B565_2747	COG1566	PFAM secretion protein HlyD family protein
B565_2754	COG0446	pyridine nucleotide-disulphide oxidoreductase
B565_2756	COG1285	pathogenesis
B565_2762	COG0484	heat shock protein binding
B565_2763	COG0443	Heat shock 70 kDa protein
B565_2764	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B565_2765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B565_2766	COG0497	DNA recombination
B565_2767	COG1227	inorganic diphosphatase activity
B565_2768	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_2769	COG1136	(ABC) transporter
B565_2769	COG0577	efflux transmembrane transporter activity
B565_2770	COG1538	Outer membrane efflux protein
B565_2776	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B565_2781	COG1086	Polysaccharide biosynthesis protein
B565_2784	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B565_2784	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B565_2787	COG1028	Short-chain dehydrogenase reductase Sdr
B565_2789	COG0673	inositol 2-dehydrogenase activity
B565_2792	COG2089	acid synthase
B565_2793	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B565_2794	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B565_2797	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B565_2798	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_2799	COG1309	transcriptional regulator
B565_2802	COG1342	Belongs to the UPF0251 family
B565_2806	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B565_2811	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B565_2812	COG0083	homoserine kinase activity
B565_2814	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B565_2815	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
B565_2816	COG1946	Acyl-CoA thioesterase
B565_2818	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B565_2820	COG0009	L-threonylcarbamoyladenylate synthase
B565_2822	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B565_2823	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B565_2823	COG0512	Glutamine amidotransferase of anthranilate synthase
B565_2824	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B565_2825	COG0134	indole-3-glycerol-phosphate synthase activity
B565_2825	COG0135	phosphoribosylanthranilate isomerase activity
B565_2826	COG0133	tryptophan synthase activity
B565_2827	COG0159	tryptophan synthase activity
B565_2829	COG1988	membrane-bound metal-dependent
B565_2832	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B565_2834	COG0798	PFAM Bile acid sodium symporter
B565_2840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B565_2842	COG0745	RESPONSE REGULATOR receiver
B565_2843	COG4988	ABC transporter
B565_2844	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B565_2848	COG1720	tRNA m6t6A37 methyltransferase activity
B565_2849	COG3038	cytochrome b561
B565_2851	COG0745	RESPONSE REGULATOR receiver
B565_2857	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B565_2858	COG1396	sequence-specific DNA binding
B565_2858	COG1917	Cupin 2, conserved barrel domain protein
B565_2859	COG1012	belongs to the aldehyde dehydrogenase family
B565_2861	COG0531	amino acid
B565_2862	COG0531	amino acid
B565_2863	COG1283	sodium-dependent phosphate transmembrane transporter activity
B565_2865	COG0405	Gamma-glutamyltransferase
B565_2866	COG2974	May be involved in recombination
B565_2868	COG0420	3'-5' exonuclease activity
B565_2869	COG0419	ATPase involved in DNA repair
B565_2870	COG3384	dioxygenase
B565_2872	COG0469	pyruvate kinase activity
B565_2873	COG1196	nuclear chromosome segregation
B565_2873	COG3264	Mechanosensitive ion channel
B565_2877	COG3590	peptidase
B565_2878	COG3706	GGDEF domain
B565_2879	COG2190	(PTS) system
B565_2881	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_2882	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B565_2883	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B565_2886	COG2770	Histidine kinase
B565_2886	COG3437	response regulator, receiver
B565_2887	COG3409	Peptidoglycan-binding domain 1 protein
B565_2887	COG3267	Type II secretory pathway component ExeA
B565_2889	COG3031	protein transport across the cell outer membrane
B565_2891	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B565_2892	COG1459	type II secretion system
B565_2893	COG2165	general secretion pathway protein
B565_2895	COG2165	general secretion pathway protein
B565_2896	COG4795	General secretion pathway protein
B565_2897	COG3156	type II secretion system protein K
B565_2899	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B565_2901	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B565_2902	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B565_2903	COG2723	6-phospho-beta-galactosidase activity
B565_2904	COG1447	Phosphotransferase system cellobiose-specific component IIA
B565_2905	COG2169	Transcriptional regulator
B565_2905	COG1917	Cupin 2, conserved barrel domain protein
B565_2906	COG1486	melibiose metabolic process
B565_2908	COG0670	Belongs to the BI1 family
B565_2909	COG1289	transmembrane transporter activity
B565_2910	COG2920	part of a sulfur-relay system
B565_2911	COG0673	inositol 2-dehydrogenase activity
B565_2912	COG0583	DNA-binding transcription factor activity
B565_2922	COG1032	radical SAM domain protein
B565_2924	COG1566	PFAM secretion protein HlyD family protein
B565_2925	COG3706	GGDEF domain
B565_2926	COG1752	Esterase of the alpha-beta hydrolase superfamily
B565_2927	COG0531	amino acid
B565_2933	COG0281	malic enzyme
B565_2935	COG0534	Mate efflux family protein
B565_2937	COG3706	GGDEF domain
B565_2938	COG2233	PERMEase
B565_2939	COG0095	Lipoate-protein ligase
B565_2941	COG1115	amino acid carrier protein
B565_2942	COG0019	diaminopimelate decarboxylase activity
B565_2944	COG0678	peroxiredoxin activity
B565_2949	COG0545	Peptidyl-prolyl cis-trans isomerase
B565_2950	COG3142	Participates in the control of copper homeostasis
B565_2953	COG4783	chaperone-mediated protein folding
B565_2955	COG5002	protein histidine kinase activity
B565_2956	COG0745	RESPONSE REGULATOR receiver
B565_2957	COG0346	lactoylglutathione lyase activity
B565_2958	COG3284	Transcriptional regulator
B565_2959	COG1012	belongs to the aldehyde dehydrogenase family
B565_2961	COG0697	spore germination
B565_2963	COG3290	protein histidine kinase activity
B565_2964	COG0281	malic enzyme
B565_2967	COG1846	Transcriptional regulator
B565_2968	COG1566	PFAM secretion protein HlyD family protein
B565_2974	COG0602	queuosine metabolic process
B565_2975	COG1328	CTP reductase activity
B565_2978	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B565_2979	COG3115	cell septum assembly
B565_2980	COG1196	nuclear chromosome segregation
B565_2982	COG2860	membrane
B565_2984	COG3108	Peptidase M15
B565_2985	COG2989	Protein conserved in bacteria
B565_2988	COG0463	Glycosyl transferase, family 2
B565_2991	COG0366	Alpha amylase catalytic
B565_2998	COG2203	Gaf domain
B565_2998	COG2199	diguanylate cyclase activity
B565_3000	COG3590	peptidase
B565_3002	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B565_3003	COG1982	Orn Lys Arg decarboxylase major
B565_3004	COG0531	amino acid
B565_3006	COG3710	Transcriptional regulator
B565_3007	COG0531	amino acid
B565_3011	COG0814	amino acid
B565_3017	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B565_3018	COG0739	heme binding
B565_3019	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B565_3021	COG0251	oxidation-reduction process
B565_3022	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B565_3024	COG3091	SprT-like family
B565_3026	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B565_3027	COG0189	ligase activity
B565_3028	COG1678	Uncharacterized ACR, COG1678
B565_3029	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B565_3030	COG3104	oligopeptide transport
B565_3031	COG0583	DNA-binding transcription factor activity
B565_3033	COG0714	Associated with various cellular activities
B565_3036	COG1115	amino acid carrier protein
B565_3037	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B565_3039	COG0825	malonyl-CoA metabolic process
B565_3041	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B565_3042	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B565_3043	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B565_3044	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B565_3045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B565_3048	COG0750	zinc metalloprotease
B565_3049	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B565_3050	COG0575	Belongs to the CDS family
B565_3052	COG0233	cytoplasmic translational termination
B565_3053	COG0528	UMP kinase activity
B565_3054	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B565_3055	COG0052	Belongs to the universal ribosomal protein uS2 family
B565_3056	COG0024	Methionine aminopeptidase
B565_3058	COG2171	N-acyltransferase activity
B565_3060	COG1263	PTS System
B565_3060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_3062	COG4580	involved in the transport of maltose and maltodextrins
B565_3064	COG0564	pseudouridine synthase activity
B565_3065	COG3098	single-species biofilm formation
B565_3070	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B565_3072	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B565_3072	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B565_3074	COG3706	GGDEF domain
B565_3075	COG1611	Belongs to the LOG family
B565_3076	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B565_3077	COG0473	3-isopropylmalate dehydrogenase activity
B565_3079	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B565_3080	COG2363	Small membrane protein
B565_3082	COG0583	DNA-binding transcription factor activity
B565_3083	COG0840	transmembrane signaling receptor activity
B565_3084	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B565_3087	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B565_3088	COG1666	GTP binding
B565_3090	COG2211	Major facilitator Superfamily
B565_3091	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B565_3093	COG2813	Specifically methylates the guanine in position
B565_3094	COG0271	Belongs to the BolA IbaG family
B565_3095	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B565_3096	COG1805	sodium ion transport
B565_3098	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B565_3099	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
B565_3100	COG2871	sodium ion transport
B565_3101	COG1477	protein flavinylation
B565_3107	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B565_3110	COG0300	oxidoreductase activity
B565_3112	COG0415	Belongs to the DNA photolyase family
B565_3113	COG0789	Transcriptional regulator
B565_3114	COG3272	Protein of unknown function (DUF1722)
B565_3120	COG1605	Chorismate mutase
B565_3120	COG0077	Prephenate dehydratase
B565_3125	COG5377	YqaJ viral recombinase family
B565_3133	COG2003	Belongs to the UPF0758 family
B565_3135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B565_3140	COG0514	ATP-dependent DNA helicase (RecQ)
B565_3144	COG0514	ATP-dependent DNA helicase (RecQ)
B565_3145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B565_3147	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B565_3154	COG0840	transmembrane signaling receptor activity
B565_3156	COG0300	oxidoreductase activity
B565_3161	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B565_3169	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B565_3170	COG0826	peptidase U32
B565_3171	COG1280	lysine exporter protein (LysE YggA)
B565_3173	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B565_3177	COG2198	Histidine kinase
B565_3177	COG0643	Histidine kinase
B565_3179	COG0835	chemotaxis
B565_3180	COG0840	transmembrane signaling receptor activity
B565_3182	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B565_3183	COG2201	protein-glutamate methylesterase activity
B565_3184	COG1185	polyribonucleotide nucleotidyltransferase activity
B565_3185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B565_3186	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B565_3187	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B565_3188	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B565_3189	COG0195	Participates in both transcription termination and antitermination
B565_3190	COG0779	Required for maturation of 30S ribosomal subunits
B565_3191	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B565_3192	COG0149	triose-phosphate isomerase activity
B565_3193	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B565_3194	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B565_3195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B565_3196	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B565_3197	COG1534	Rna-binding protein
B565_3199	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B565_3200	COG1360	Flagellar Motor Protein
B565_3201	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B565_3202	COG1722	exodeoxyribonuclease VII activity
B565_3203	COG0142	geranyltranstransferase activity
B565_3204	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B565_3205	COG0737	Belongs to the 5'-nucleotidase family
B565_3209	COG2204	response regulator
B565_3210	COG0545	Peptidyl-prolyl cis-trans isomerase
B565_3212	COG2900	Belongs to the SlyX family
B565_3217	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B565_3218	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B565_3219	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B565_3220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B565_3223	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B565_3223	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B565_3224	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B565_3225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B565_3227	COG0784	Response regulator, receiver
B565_3227	COG2205	protein histidine kinase activity
B565_3227	COG2198	Histidine kinase
B565_3228	COG1879	ABC-type sugar transport system periplasmic component
B565_3230	COG0745	RESPONSE REGULATOR receiver
B565_3231	COG3005	denitrification pathway
B565_3233	COG3381	protein complex oligomerization
B565_3237	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B565_3238	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B565_3239	COG0511	ligase activity, forming carbon-carbon bonds
B565_3240	COG0439	Biotin carboxylase
B565_3242	COG4145	pantothenate transmembrane transporter activity
B565_3243	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_3243	COG1263	PTS System
B565_3243	COG2190	(PTS) system
B565_3244	COG0583	DNA-binding transcription factor activity
B565_3245	COG0604	alcohol dehydrogenase
B565_3246	COG2264	protein methyltransferase activity
B565_3247	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B565_3248	COG0110	maltose O-acetyltransferase activity
B565_3249	COG0778	Nitroreductase
B565_3250	COG1902	pentaerythritol trinitrate reductase activity
B565_3250	COG0446	pyridine nucleotide-disulphide oxidoreductase
B565_3251	COG0616	signal peptide processing
B565_3255	COG0848	biopolymer transport protein
B565_3256	COG0811	peptide transport
B565_3257	COG0811	peptide transport
B565_3261	COG4174	ABC transporter (Permease)
B565_3262	COG4239	(ABC) transporter, permease
B565_3264	COG0444	Belongs to the ABC transporter superfamily
B565_3265	COG4608	Belongs to the ABC transporter superfamily
B565_3269	COG3416	Protein conserved in bacteria
B565_3271	COG0741	lytic transglycosylase activity
B565_3274	COG0488	(ABC) transporter
B565_3276	COG2252	PERMEase
B565_3277	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B565_3278	COG0840	transmembrane signaling receptor activity
B565_3280	COG1278	Cold shock
B565_3281	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B565_3282	COG1162	GTPase activity
B565_3283	COG0688	phosphatidylethanolamine metabolic process
B565_3284	COG4628	conserved protein (DUF2132)
B565_3287	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B565_3291	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B565_3292	COG2195	Cleaves the N-terminal amino acid of tripeptides
B565_3293	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B565_3294	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B565_3295	COG3178	'Phosphotransferase
B565_3296	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B565_3297	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B565_3298	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B565_3299	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B565_3301	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B565_3303	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B565_3305	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B565_3306	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B565_3307	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B565_3308	COG0142	geranyltranstransferase activity
B565_3309	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B565_3310	COG0330	HflC and HflK could
B565_3311	COG0330	HflC and HflK could
B565_3312	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B565_3313	COG1923	regulation of RNA biosynthetic process
B565_3314	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B565_3315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B565_3316	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B565_3317	COG0860	N-Acetylmuramoyl-L-alanine amidase
B565_3318	COG0802	atpase or kinase
B565_3319	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B565_3319	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B565_3323	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B565_3324	COG2011	ABC-type metal ion transport system permease component
B565_3325	COG1464	Belongs to the NlpA lipoprotein family
B565_3332	COG0784	Response regulator, receiver
B565_3332	COG5002	protein histidine kinase activity
B565_3332	COG2198	Histidine kinase
B565_3340	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B565_3341	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B565_3342	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B565_3343	COG2716	regulation of RNA biosynthetic process
B565_3344	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B565_3345	COG3013	Belongs to the UPF0304 family
B565_3346	COG3092	negative regulation of chromosome organization
B565_3347	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B565_3348	COG0280	phosphate acetyltransferase
B565_3348	COG0857	belongs to the CobB CobQ family
B565_3349	COG1555	photosystem II stabilization
B565_3350	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B565_3351	COG3104	oligopeptide transport
B565_3352	COG0745	RESPONSE REGULATOR receiver
B565_3359	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B565_3362	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B565_3369	COG0440	acetolactate synthase activity
B565_3370	COG0028	Belongs to the TPP enzyme family
B565_3373	COG0671	phosphoesterase, PA-phosphatase related
B565_3375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B565_3376	COG0473	3-isopropylmalate dehydrogenase activity
B565_3377	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B565_3378	COG0066	3-isopropylmalate dehydratase activity
B565_3381	COG4143	(ABC) transporter
B565_3382	COG1178	ABC-type Fe3 transport system permease component
B565_3383	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B565_3384	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B565_3390	COG0459	protein refolding
B565_3391	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B565_3393	COG3030	protein affecting phage T7 exclusion by the F plasmid
B565_3394	COG1027	Aspartate ammonia-lyase
B565_3395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B565_3396	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B565_3397	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B565_3398	COG1610	YqeY-like protein
B565_3399	COG0358	DNA primase activity
B565_3400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B565_3403	COG0151	Belongs to the GarS family
B565_3404	COG0138	bifunctional purine biosynthesis protein purh
B565_3406	COG3036	rescue of stalled ribosome
B565_3407	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B565_3408	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B565_3410	COG0673	inositol 2-dehydrogenase activity
B565_3412	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B565_3413	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B565_3415	COG0583	DNA-binding transcription factor activity
B565_3416	COG0477	Major facilitator Superfamily
B565_3419	COG1028	Short-chain dehydrogenase reductase Sdr
B565_3420	COG3706	GGDEF domain
B565_3420	COG0745	RESPONSE REGULATOR receiver
B565_3421	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B565_3424	COG0456	acetyltransferase
B565_3426	COG1022	Amp-dependent synthetase and ligase
B565_3427	COG2918	glutathione biosynthetic process
B565_3428	COG0612	Peptidase, M16
B565_3429	COG1238	metal cluster binding
B565_3430	COG1064	alcohol dehydrogenase
B565_3435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B565_3436	COG0359	binds to the 23S rRNA
B565_3437	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B565_3438	COG0360	Binds together with S18 to 16S ribosomal RNA
B565_3439	COG1914	H( )-stimulated, divalent metal cation uptake system
B565_3440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B565_3442	COG0776	regulation of translation
B565_3445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B565_3448	COG0560	Phosphoserine phosphatase
B565_3450	COG0813	purine-nucleoside phosphorylase activity
B565_3451	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B565_3452	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B565_3453	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B565_3455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B565_3456	COG0084	hydrolase, TatD family'
B565_3458	COG1854	S-ribosylhomocysteine lyase activity
B565_3461	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B565_3461	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B565_3470	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B565_3471	COG1047	Peptidyl-prolyl cis-trans
B565_3472	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B565_3473	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B565_3474	COG0196	riboflavin kinase activity
B565_3475	COG0728	peptidoglycan biosynthetic process
B565_3476	COG0268	Binds directly to 16S ribosomal RNA
B565_3477	COG0640	Transcriptional regulator
B565_3478	COG0583	DNA-binding transcription factor activity
B565_3480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B565_3481	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B565_3482	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B565_3483	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B565_3484	COG1051	belongs to the nudix hydrolase family
B565_3485	COG3066	DNA modification
B565_3487	COG0335	large ribosomal subunit rRNA binding
B565_3488	COG0336	Belongs to the RNA methyltransferase TrmD family
B565_3489	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B565_3490	COG0228	four-way junction DNA binding
B565_3491	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B565_3492	COG4137	Cytochrome C assembly protein
B565_3493	COG4536	flavin adenine dinucleotide binding
B565_3495	COG1017	nitric oxide dioxygenase activity
B565_3495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B565_3496	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B565_3497	COG0039	L-malate dehydrogenase activity
B565_3498	COG4160	amino acid transport
B565_3499	COG4215	(ABC) transporter
B565_3500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_3501	COG1126	abc transporter atp-binding protein
B565_3502	COG1438	arginine binding
B565_3503	COG2837	iron assimilation
B565_3504	COG3842	ATPase activity
B565_3506	COG1840	ABC-type Fe3 transport system, periplasmic component
B565_3507	COG0347	Belongs to the P(II) protein family
B565_3511	COG3022	response to hydroperoxide
B565_3514	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B565_3515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B565_3516	COG0762	integral membrane protein
B565_3517	COG1872	DUF167
B565_3519	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B565_3520	COG0583	DNA-binding transcription factor activity
B565_3523	COG1929	Belongs to the glycerate kinase type-1 family
B565_3524	COG2610	gluconate transmembrane transporter activity
B565_3525	COG3835	regulator
B565_3526	COG3112	Uncharacterised protein family (UPF0231)
B565_3530	COG3568	Endonuclease Exonuclease Phosphatase
B565_3532	COG0513	Belongs to the DEAD box helicase family
B565_3541	COG1448	Aminotransferase
B565_3544	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B565_3545	COG1328	CTP reductase activity
B565_3550	COG0543	2 iron, 2 sulfur cluster binding
B565_3550	COG0633	Ferredoxin
B565_3556	COG0840	transmembrane signaling receptor activity
B565_3557	COG3397	chitin binding
B565_3558	COG3174	membrane
B565_3559	COG0110	maltose O-acetyltransferase activity
B565_3562	COG1011	Hydrolase
B565_3563	COG0494	nUDIX hydrolase
B565_3564	COG1218	3'(2'),5'-bisphosphate nucleotidase
B565_3565	COG0814	amino acid
B565_3566	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B565_3569	COG0626	cystathionine gamma-synthase activity
B565_3570	COG0460	homoserine dehydrogenase
B565_3570	COG0527	aspartate kinase activity
B565_3571	COG0306	phosphate transporter
B565_3572	COG1392	Phosphate transport regulator
B565_3574	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B565_3575	COG2813	Specifically methylates the guanine in position
B565_3576	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B565_3577	COG0297	glycogen (starch) synthase activity
B565_3580	COG1757	Na H antiporter
B565_3581	COG0316	Belongs to the HesB IscA family
B565_3583	COG0038	chloride channel
B565_3584	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B565_3586	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B565_3586	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B565_3587	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B565_3588	COG0564	pseudouridine synthase activity
B565_3590	COG0110	maltose O-acetyltransferase activity
B565_3591	COG0366	Alpha amylase catalytic
B565_3592	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B565_3592	COG1263	PTS System
B565_3596	COG0252	asparaginase activity
B565_3597	COG1253	flavin adenine dinucleotide binding
B565_3598	COG0586	Pfam SNARE associated Golgi protein
B565_3599	COG1686	Belongs to the peptidase S11 family
B565_3600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B565_3601	COG0527	aspartate kinase activity
B565_3602	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B565_3604	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B565_3605	COG1546	Belongs to the CinA family
B565_3606	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B565_3607	COG4667	esterase of the alpha-beta hydrolase superfamily
B565_3609	COG1346	cytolysis
B565_3610	COG1380	Effector of murein hydrolase LrgA
B565_3611	COG0583	DNA-binding transcription factor activity
B565_3615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B565_3620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B565_3621	COG2022	thiamine diphosphate biosynthetic process
B565_3623	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B565_3624	COG0352	thiamine-phosphate diphosphorylase activity
B565_3625	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B565_3629	COG0745	RESPONSE REGULATOR receiver
B565_3631	COG0189	ligase activity
B565_3636	COG1757	Na H antiporter
B565_3637	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B565_3643	COG0477	Major facilitator Superfamily
B565_3646	COG0312	modulator of DNA gyrase
B565_3647	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B565_3648	COG3164	Protein of unknown function
B565_3649	COG1530	ribonuclease E activity
B565_3650	COG0424	maF-like protein
B565_3651	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B565_3652	COG1792	Involved in formation and maintenance of cell shape
B565_3653	COG1077	Cell shape determining protein MreB Mrl
B565_3658	COG4968	Prepilin-type N-terminal cleavage methylation domain
B565_3659	COG4969	Belongs to the N-Me-Phe pilin family
B565_3662	COG1459	type II secretion system
B565_3663	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B565_3672	COG2200	EAL domain
B565_3672	COG2199	diguanylate cyclase activity
B565_3673	COG2200	EAL domain
B565_3674	COG0387	Pfam Sodium calcium exchanger
B565_3675	COG2986	histidine ammonia-lyase
B565_3676	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B565_3677	COG0010	Belongs to the arginase family
B565_3678	COG1228	amidohydrolase
B565_3679	COG2188	Transcriptional regulator
B565_3680	COG0288	reversible hydration of carbon dioxide
B565_3682	COG2177	Part of the ABC transporter FtsEX involved in
B565_3683	COG2884	Cell division ATP-binding protein ftsE
B565_3684	COG0552	protein localization to endoplasmic reticulum
B565_3685	COG0742	ribosomal rna small subunit methyltransferase
B565_3690	COG2249	NAD(P)H dehydrogenase (quinone) activity
B565_3691	COG0583	DNA-binding transcription factor activity
B565_3692	COG4221	oxidoreductase activity
B565_3695	COG1770	oligopeptidase
B565_3698	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B565_3700	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B565_3702	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B565_3704	COG2095	MarC family integral membrane protein
B565_3706	COG1301	dicarboxylic acid transport
B565_3711	COG3714	YhhN family
B565_3716	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B565_3717	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B565_3718	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B565_3719	COG0049	tRNA binding
B565_3720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B565_3721	COG2168	tRNA wobble position uridine thiolation
B565_3722	COG2923	Belongs to the DsrF TusC family
B565_3723	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B565_3725	COG2964	Protein conserved in bacteria
B565_3726	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B565_3727	COG0085	RNA polymerase activity
B565_3728	COG0222	ribosome binding
B565_3729	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B565_3730	COG0081	regulation of translation
B565_3731	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B565_3732	COG0250	Participates in transcription elongation, termination and antitermination
B565_3733	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B565_3735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B565_3738	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B565_3739	COG0569	domain protein
B565_3740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B565_3746	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B565_3746	COG4191	Histidine kinase
B565_3747	COG3005	denitrification pathway
B565_3748	COG0243	molybdopterin cofactor binding
B565_3750	COG2205	protein histidine kinase activity
B565_3751	COG0745	RESPONSE REGULATOR receiver
B565_3757	COG2204	response regulator
B565_3759	COG2205	protein histidine kinase activity
B565_3760	COG1028	Short-chain dehydrogenase reductase Sdr
B565_3761	COG0516	GMP reductase activity
B565_3761	COG0517	IMP dehydrogenase activity
B565_3762	COG5413	integral membrane protein
B565_3764	COG1522	sequence-specific DNA binding
B565_3765	COG2502	aspartate--ammonia ligase
B565_3766	COG0542	response to heat
B565_3768	COG0564	pseudouridine synthase activity
B565_3769	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B565_3770	COG0446	pyridine nucleotide-disulphide oxidoreductase
B565_3772	COG3681	Belongs to the UPF0597 family
B565_3773	COG2964	Protein conserved in bacteria
B565_3775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B565_3776	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B565_3777	COG1979	alcohol dehydrogenase
B565_3778	COG2207	Transcriptional regulator
B565_3782	COG0583	DNA-binding transcription factor activity
B565_3785	COG0540	Belongs to the ATCase OTCase family
B565_3786	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B565_3787	COG0531	amino acid
B565_3788	COG1982	Orn Lys Arg decarboxylase major
B565_3789	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B565_3796	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B565_3798	COG3078	GTPase activator activity
B565_3800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B565_3802	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B565_3803	COG0408	coproporphyrinogen oxidase activity
B565_3804	COG0009	L-threonylcarbamoyladenylate synthase
B565_3806	COG0551	DNA topoisomerase type I activity
B565_3807	COG2922	Belongs to the Smg family
B565_3808	COG0758	DNA mediated transformation
B565_3809	COG1652	LysM domain
B565_3810	COG0242	peptide deformylase activity
B565_3811	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B565_3812	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B565_3812	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B565_3813	COG0569	domain protein
B565_3814	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B565_3816	COG0174	glutamine synthetase
B565_3818	COG3852	Histidine kinase
B565_3819	COG2204	response regulator
B565_3820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B565_3821	COG1322	Protein conserved in bacteria
B565_3825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B565_3826	COG0583	DNA-binding transcription factor activity
B565_3827	COG0519	Catalyzes the synthesis of GMP from XMP
B565_3827	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B565_3830	COG1396	sequence-specific DNA binding
B565_3831	COG1012	belongs to the aldehyde dehydrogenase family
B565_3833	COG2962	Rard protein
B565_3834	COG0840	transmembrane signaling receptor activity
B565_3835	COG2391	methyltransferase activity
B565_3838	COG0129	dihydroxy-acid dehydratase activity
B565_3839	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B565_3840	COG3978	acetolactate synthase activity
B565_3842	COG0606	chelatase, subunit chli
B565_3843	COG0204	Acyl-transferase
B565_3844	COG0204	Acyl-transferase
B565_3846	COG1335	isochorismatase
B565_3848	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B565_3849	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B565_3851	COG3084	Protein conserved in bacteria
B565_3852	COG3706	GGDEF domain
B565_3852	COG5001	Diguanylate cyclase
B565_3852	COG4251	negative regulation of phosphorylation
B565_3852	COG2203	Gaf domain
B565_3855	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B565_3856	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B565_3857	COG1561	YicC-like family, N-terminal region
B565_3858	COG0583	DNA-binding transcription factor activity
B565_3862	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B565_3863	COG0385	Bile acid
B565_3864	COG0531	amino acid
B565_3865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B565_3866	COG0531	amino acid
B565_3867	COG2731	YhcH YjgK YiaL family protein
B565_3868	COG3250	beta-galactosidase activity
B565_3869	COG1609	Transcriptional regulator
B565_3870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B565_3871	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B565_3871	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B565_3872	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B565_3873	COG3074	FtsZ-dependent cytokinesis
B565_3875	COG1045	serine acetyltransferase
B565_3877	COG0745	RESPONSE REGULATOR receiver
B565_3878	COG2205	protein histidine kinase activity
B565_3879	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B565_3880	COG0534	Mate efflux family protein
B565_3883	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B565_3884	COG2937	Belongs to the GPAT DAPAT family
B565_3885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B565_3886	COG3161	chorismate lyase activity
B565_3890	COG0604	alcohol dehydrogenase
B565_3891	COG1609	Transcriptional regulator
B565_3892	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B565_3895	COG1519	Transferase
B565_3896	COG0859	PFAM glycosyl transferase family 9
B565_3897	COG0463	Glycosyl transferase, family 2
B565_3898	COG0859	PFAM glycosyl transferase family 9
B565_3899	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B565_3900	COG2990	Protein conserved in bacteria
B565_3901	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B565_3903	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B565_3904	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B565_3905	COG2003	Belongs to the UPF0758 family
B565_3906	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B565_3907	COG0756	dUTP diphosphatase activity
B565_3908	COG4974	Belongs to the 'phage' integrase family
B565_3919	COG0756	dUTP diphosphatase activity
B565_3920	COG0756	dUTP diphosphatase activity
B565_3921	COG1309	transcriptional regulator
B565_3922	COG0668	transmembrane transport
B565_3923	COG0166	Belongs to the GPI family
B565_3924	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B565_3925	COG0583	DNA-binding transcription factor activity
B565_3928	COG0045	succinate-CoA ligase (ADP-forming) activity
B565_3928	COG1042	CoA-binding domain protein
B565_3928	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B565_3929	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B565_3930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B565_3931	COG1739	Uncharacterized protein family UPF0029
B565_3932	COG0006	proline dipeptidase activity
B565_3933	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B565_3934	COG1250	3-hydroxyacyl-CoA dehydrogenase
B565_3934	COG1024	Enoyl-CoA hydratase
B565_3935	COG0183	Belongs to the thiolase family
B565_3936	COG0745	RESPONSE REGULATOR receiver
B565_3937	COG2205	protein histidine kinase activity
B565_3940	COG0425	Belongs to the sulfur carrier protein TusA family
B565_3941	COG0251	oxidation-reduction process
B565_3942	COG2885	chlorophyll binding
B565_3943	COG2818	Glycosylase
B565_3944	COG0752	glycyl-tRNA synthetase alpha subunit
B565_3945	COG0751	glycine-tRNA ligase activity
B565_3947	COG2199	diguanylate cyclase activity
B565_3947	COG2202	Pas domain
B565_3947	COG2200	EAL domain
B565_3949	COG0840	transmembrane signaling receptor activity
B565_3950	COG2188	Transcriptional regulator
B565_3953	COG1609	Transcriptional regulator
B565_3955	COG0559	Belongs to the binding-protein-dependent transport system permease family
B565_3959	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B565_3962	COG2960	long-chain fatty acid transporting porin activity
B565_3963	COG5001	Diguanylate cyclase
B565_3965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B565_3967	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B565_3968	COG3118	belongs to the thioredoxin family
B565_3969	COG0513	Belongs to the DEAD box helicase family
B565_3970	COG0248	Ppx GppA phosphatase
B565_3972	COG0742	ribosomal rna small subunit methyltransferase
B565_3976	COG3469	chitinase activity
B565_3979	COG0084	hydrolase, TatD family'
B565_3980	COG0805	protein transport
B565_3981	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B565_3982	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B565_3983	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B565_3984	COG3165	ubiquinone biosynthetic process from chorismate
B565_3985	COG2226	methyltransferase
B565_3986	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B565_3987	COG0402	S-adenosylhomocysteine deaminase activity
B565_3988	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B565_3990	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B565_3991	COG0848	biopolymer transport protein
B565_3992	COG0811	peptide transport
B565_3993	COG0811	peptide transport
B565_3995	COG2771	luxR family
B565_3996	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B565_3997	COG1349	DNA-binding transcription factor activity
B565_3998	COG0745	RESPONSE REGULATOR receiver
B565_3999	COG2205	protein histidine kinase activity
B565_4002	COG4452	Inner membrane protein CreD
B565_4003	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B565_4004	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B565_4005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B565_4006	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B565_4007	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B565_4008	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B565_4009	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B565_4011	COG0356	it plays a direct role in the translocation of protons across the membrane
B565_4013	COG1475	DNA binding
B565_4014	COG1192	Involved in chromosome partitioning
B565_4015	COG0357	Ribosomal RNA small subunit methyltransferase G
B565_4016	COG0445	tRNA wobble uridine modification
B565_4017	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B565_4019	COG4615	Cyclic peptide transporter
B565_4020	COG1120	ATPase activity
B565_4021	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B565_4022	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B565_4023	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B565_4024	COG0706	membrane insertase activity
B565_4025	COG0594	ribonuclease P activity