locus-tag	class	description
A6033_00030	COG1858	cytochrome C peroxidase
A6033_00035	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A6033_00045	COG2199	diguanylate cyclase activity
A6033_00045	COG2203	Gaf domain
A6033_00050	COG0513	Belongs to the DEAD box helicase family
A6033_00075	COG0154	amidase activity
A6033_00080	COG2957	Belongs to the agmatine deiminase family
A6033_00090	COG2852	Protein conserved in bacteria
A6033_00100	COG1902	pentaerythritol trinitrate reductase activity
A6033_00115	COG1238	metal cluster binding
A6033_00120	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6033_00125	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6033_00130	COG0585	pseudouridine synthase activity
A6033_00140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6033_00145	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6033_00150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6033_00160	COG1376	ErfK ybiS ycfS ynhG family protein
A6033_00165	COG0668	transmembrane transport
A6033_00175	COG2731	YhcH YjgK YiaL family protein
A6033_00185	COG1794	racemase activity, acting on amino acids and derivatives
A6033_00200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6033_00230	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6033_00270	COG0148	phosphopyruvate hydratase activity
A6033_00275	COG0504	CTP synthase activity
A6033_00280	COG3956	TIGRFAM MazG family protein
A6033_00285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6033_00290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6033_00300	COG4807	Protein conserved in bacteria
A6033_00305	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6033_00310	COG0783	Belongs to the Dps family
A6033_00315	COG1151	hydroxylamine reductase activity
A6033_00320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6033_00325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6033_00330	COG0671	phosphoesterase, PA-phosphatase related
A6033_00340	COG0163	prenyltransferase activity
A6033_00355	COG1131	(ABC) transporter
A6033_00360	COG0842	Transport permease protein
A6033_00365	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A6033_00370	COG1924	4 iron, 4 sulfur cluster binding
A6033_00405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6033_00410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6033_00420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6033_00425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6033_00430	COG1489	DNA binding
A6033_00440	COG1643	Atp-dependent helicase
A6033_00445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6033_00450	COG0346	lactoylglutathione lyase activity
A6033_00455	COG2076	Multidrug Resistance protein
A6033_00460	COG2076	Multidrug Resistance protein
A6033_00475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6033_00490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6033_00525	COG0840	transmembrane signaling receptor activity
A6033_00540	COG0529	Catalyzes the synthesis of activated sulfate
A6033_00545	COG3273	potassium ion transport
A6033_00545	COG0471	metal ion transport
A6033_00550	COG2895	sulfate adenylyltransferase (ATP) activity
A6033_00555	COG0175	sulfate reduction
A6033_00570	COG1585	Membrane protein implicated in regulation of membrane protease activity
A6033_00575	COG0840	transmembrane signaling receptor activity
A6033_00580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6033_00590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6033_00595	COG1640	4-alpha-glucanotransferase
A6033_00600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6033_00635	COG1522	sequence-specific DNA binding
A6033_00650	COG0561	phosphatase activity
A6033_00665	COG0733	neurotransmitter:sodium symporter activity
A6033_00675	COG0733	neurotransmitter:sodium symporter activity
A6033_00740	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6033_00745	COG2885	chlorophyll binding
A6033_00750	COG0823	Involved in the tonB-independent uptake of proteins
A6033_00765	COG0811	peptide transport
A6033_00770	COG0824	Thioesterase
A6033_00780	COG4890	Cyd operon protein YbgT
A6033_00785	COG1294	oxidase, subunit
A6033_00795	COG2255	four-way junction helicase activity
A6033_00800	COG0632	four-way junction helicase activity
A6033_00805	COG0840	transmembrane signaling receptor activity
A6033_00815	COG2771	luxR family
A6033_00820	COG3916	Acyl-homoserine-lactone synthase
A6033_00830	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
A6033_00835	COG2203	Gaf domain
A6033_00835	COG5001	Diguanylate cyclase
A6033_00835	COG4251	negative regulation of phosphorylation
A6033_00835	COG3706	GGDEF domain
A6033_00845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6033_00860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6033_00860	COG3008	intermembrane lipid transfer
A6033_00870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6033_00875	COG0442	prolyl-tRNA aminoacylation
A6033_00880	COG4221	oxidoreductase activity
A6033_00895	COG1024	Enoyl-CoA hydratase
A6033_00905	COG0110	maltose O-acetyltransferase activity
A6033_00915	COG4166	transmembrane transport
A6033_00925	COG0840	transmembrane signaling receptor activity
A6033_00930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6033_01015	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6033_01020	COG0513	Belongs to the DEAD box helicase family
A6033_01025	COG2153	protein acetylation
A6033_01045	COG0557	exoribonuclease II activity
A6033_01050	COG3706	GGDEF domain
A6033_01060	COG3240	lipase activity
A6033_01065	COG3111	PFAM Bacterial OB fold (BOF) protein
A6033_01075	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6033_01080	COG1194	a g-specific adenine glycosylase
A6033_01085	COG0617	tRNA 3'-terminal CCA addition
A6033_01105	COG3068	Protein conserved in bacteria
A6033_01135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6033_01140	COG1121	(ABC) transporter
A6033_01145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6033_01150	COG0583	DNA-binding transcription factor activity
A6033_01155	COG0697	spore germination
A6033_01160	COG1573	uracil-dna glycosylase
A6033_01175	COG2827	Endonuclease containing a URI domain
A6033_01190	COG1842	Phage shock protein A
A6033_01195	COG0204	Acyl-transferase
A6033_01215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6033_01220	COG0583	DNA-binding transcription factor activity
A6033_01265	COG0187	DNA topoisomerase II activity
A6033_01270	COG3150	esterase
A6033_01280	COG3151	Protein conserved in bacteria
A6033_01285	COG0494	nUDIX hydrolase
A6033_01290	COG1538	Outer membrane efflux protein
A6033_01295	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6033_01295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6033_01300	COG1560	Kdo2-lipid A biosynthetic process
A6033_01305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_01305	COG2213	PTS system mannitol-specific
A6033_01310	COG0246	Mannitol dehydrogenase
A6033_01325	COG0484	heat shock protein binding
A6033_01345	COG1671	Belongs to the UPF0178 family
A6033_01350	COG1988	membrane-bound metal-dependent
A6033_01355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6033_01360	COG0513	Belongs to the DEAD box helicase family
A6033_01380	COG1575	Belongs to the MenA family. Type 1 subfamily
A6033_01385	COG1169	isochorismate synthase
A6033_01390	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6033_01400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6033_01405	COG1441	menaquinone biosynthetic process
A6033_01410	COG0318	PFAM AMP-dependent synthetase and ligase
A6033_01420	COG2949	membrane
A6033_01425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6033_01435	COG0784	Response regulator, receiver
A6033_01435	COG0835	chemotaxis
A6033_01440	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_01445	COG1444	tRNA N-acetyltransferase activity
A6033_01465	COG1803	Methylglyoxal synthase
A6033_01470	COG1979	alcohol dehydrogenase
A6033_01485	COG4221	oxidoreductase activity
A6033_01535	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6033_01545	COG1546	Belongs to the CinA family
A6033_01545	COG1058	Belongs to the CinA family
A6033_01555	COG0561	phosphatase activity
A6033_01565	COG2926	Belongs to the UPF0265 family
A6033_01605	COG1396	sequence-specific DNA binding
A6033_01610	COG3135	benzoate transporter
A6033_01635	COG0840	transmembrane signaling receptor activity
A6033_01640	COG3047	cAMP biosynthetic process
A6033_01645	COG3706	GGDEF domain
A6033_01650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6033_01670	COG1462	curli production assembly transport component CsgG
A6033_01685	COG2197	response regulator
A6033_01700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6033_01710	COG1278	Cold shock
A6033_01715	COG2252	PERMEase
A6033_01720	COG2376	Dihydroxyacetone kinase
A6033_01725	COG1461	Dihydroxyacetone kinase
A6033_01740	COG3284	Transcriptional regulator
A6033_01750	COG0628	permease
A6033_01755	COG0494	nUDIX hydrolase
A6033_01770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6033_01795	COG0456	acetyltransferase
A6033_01800	COG3133	Outer membrane lipoprotein
A6033_01805	COG0004	ammonium transporteR
A6033_01810	COG3706	GGDEF domain
A6033_01820	COG3932	Exopolysaccharide synthesis, ExoD
A6033_01850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6033_01855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6033_01870	COG2814	Major facilitator Superfamily
A6033_01875	COG0523	cobalamin synthesis protein
A6033_01885	COG2200	EAL domain
A6033_01895	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6033_01900	COG0840	transmembrane signaling receptor activity
A6033_01910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6033_01915	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6033_01920	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6033_01925	COG2186	Transcriptional regulator
A6033_01945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6033_01950	COG1459	type II secretion system
A6033_01965	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6033_01970	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6033_01980	COG0653	protein targeting
A6033_01990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6033_01995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6033_02000	COG0849	cell division
A6033_02010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6033_02015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6033_02020	COG0772	Belongs to the SEDS family
A6033_02025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6033_02030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6033_02035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6033_02045	COG0768	penicillin binding
A6033_02050	COG3116	cell division
A6033_02055	COG0275	rRNA processing
A6033_02060	COG2001	Belongs to the MraZ family
A6033_02070	COG1388	LysM domain
A6033_02070	COG0741	lytic transglycosylase activity
A6033_02080	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6033_02085	COG1191	sigma factor activity
A6033_02110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6033_02115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_02140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_02145	COG1256	bacterial-type flagellum assembly
A6033_02145	COG4786	Flagellar basal body rod
A6033_02155	COG1706	bacterial-type flagellum-dependent cell motility
A6033_02160	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6033_02165	COG4786	Flagellar basal body rod
A6033_02170	COG4787	bacterial-type flagellum-dependent cell motility
A6033_02175	COG1749	Flagellar hook protein flgE
A6033_02180	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6033_02185	COG1558	bacterial-type flagellum-dependent cell motility
A6033_02190	COG1815	bacterial-type flagellum-dependent cell motility
A6033_02225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6033_02235	COG1677	Flagellar hook-basal body complex protein FliE
A6033_02240	COG2204	response regulator
A6033_02260	COG1987	bacterial-type flagellum assembly
A6033_02285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6033_02290	COG3107	peptidoglycan biosynthetic process
A6033_02295	COG0792	nuclease activity
A6033_02300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6033_02310	COG2969	positive regulation of protein catabolic process
A6033_02315	COG0625	glutathione transferase activity
A6033_02320	COG2857	Cytochrome c1
A6033_02325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6033_02330	COG0723	plastoquinol--plastocyanin reductase activity
A6033_02335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6033_02340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6033_02345	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6033_02355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6033_02360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6033_02390	COG3964	amidohydrolase
A6033_02405	COG3711	transcriptional antiterminator
A6033_02405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_02410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_02415	COG1660	Displays ATPase and GTPase activities
A6033_02420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_02435	COG1137	ATPase activity
A6033_02440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6033_02445	COG3117	lipopolysaccharide transmembrane transporter activity
A6033_02450	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6033_02455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6033_02455	COG0517	IMP dehydrogenase activity
A6033_02460	COG1127	ABC transporter
A6033_02465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6033_02470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6033_02475	COG2854	intermembrane phospholipid transfer
A6033_02485	COG5007	Belongs to the BolA IbaG family
A6033_02490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6033_02495	COG0312	modulator of DNA gyrase
A6033_02530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6033_02570	COG0328	RNA-DNA hybrid ribonuclease activity
A6033_02595	COG3028	Belongs to the UPF0307 family
A6033_02600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6033_02620	COG1011	Hydrolase
A6033_02640	COG0019	diaminopimelate decarboxylase activity
A6033_02645	COG1965	Belongs to the frataxin family
A6033_02650	COG0400	carboxylic ester hydrolase activity
A6033_02660	COG0181	hydroxymethylbilane synthase activity
A6033_02670	COG2959	enzyme of heme biosynthesis
A6033_02685	COG1494	fructose-1,6-bisphosphatase
A6033_02705	COG0531	amino acid
A6033_02740	COG0795	lipopolysaccharide-transporting ATPase activity
A6033_02745	COG0795	lipopolysaccharide-transporting ATPase activity
A6033_02750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6033_02755	COG2927	DNA polymerase III (CHI subunit)
A6033_02780	COG0454	-acetyltransferase
A6033_02780	COG0456	acetyltransferase
A6033_02785	COG0753	catalase activity
A6033_02810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6033_02815	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6033_02845	COG2873	o-acetylhomoserine
A6033_02875	COG3842	ATPase activity
A6033_02915	COG3706	GGDEF domain
A6033_02930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6033_02935	COG1074	ATP-dependent DNA helicase activity
A6033_02940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6033_02945	COG2259	Doxx family
A6033_02950	COG1741	Belongs to the pirin family
A6033_02960	COG0583	DNA-binding transcription factor activity
A6033_02980	COG0745	RESPONSE REGULATOR receiver
A6033_02990	COG3706	GGDEF domain
A6033_03035	COG0203	ribosomal protein L17
A6033_03040	COG0202	RNA polymerase activity
A6033_03045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6033_03050	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6033_03055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6033_03060	COG0201	protein transport
A6033_03065	COG0200	Binds to the 23S rRNA
A6033_03070	COG1841	ribosomal large subunit assembly
A6033_03075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6033_03080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6033_03085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6033_03090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6033_03095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6033_03100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6033_03105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6033_03110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6033_03115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6033_03120	COG0255	Belongs to the universal ribosomal protein uL29 family
A6033_03125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6033_03130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6033_03135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6033_03140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6033_03145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6033_03150	COG0089	rRNA binding
A6033_03155	COG0088	Forms part of the polypeptide exit tunnel
A6033_03160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6033_03165	COG0051	transcription antitermination factor activity, RNA binding
A6033_03180	COG0745	RESPONSE REGULATOR receiver
A6033_03185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6033_03190	COG2183	response to ionizing radiation
A6033_03210	COG0596	Alpha beta hydrolase
A6033_03215	COG1040	competence protein
A6033_03220	COG0316	Belongs to the HesB IscA family
A6033_03220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6033_03225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6033_03230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6033_03235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6033_03240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6033_03245	COG4942	peptidase
A6033_03255	COG1609	Transcriptional regulator
A6033_03260	COG0800	Aldolase
A6033_03265	COG0129	dihydroxy-acid dehydratase activity
A6033_03270	COG3265	gluconokinase activity
A6033_03275	COG2610	gluconate transmembrane transporter activity
A6033_03280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6033_03285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6033_03295	COG0456	acetyltransferase
A6033_03300	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6033_03310	COG1295	ribonuclease BN
A6033_03315	COG0281	malic enzyme
A6033_03320	COG0814	amino acid
A6033_03335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6033_03340	COG0254	rRNA binding
A6033_03355	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6033_03360	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6033_03370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6033_03380	COG0514	ATP-dependent DNA helicase (RecQ)
A6033_03385	COG2050	protein possibly involved in aromatic compounds catabolism
A6033_03400	COG2258	MOSC domain
A6033_03405	COG1177	transmembrane transport
A6033_03410	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6033_03415	COG3842	ATPase activity
A6033_03435	COG0174	glutamine synthetase
A6033_03440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6033_03455	COG3045	CreA protein
A6033_03460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6033_03465	COG0443	Heat shock 70 kDa protein
A6033_03480	COG0366	Alpha amylase catalytic
A6033_03495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6033_03505	COG4211	Belongs to the binding-protein-dependent transport system permease family
A6033_03510	COG1129	ABC transporter
A6033_03525	COG1609	Transcriptional regulator
A6033_03530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6033_03535	COG1085	galactose-1-phosphate uridylyltransferase
A6033_03545	COG2017	converts alpha-aldose to the beta-anomer
A6033_03550	COG1968	undecaprenyl-diphosphatase activity
A6033_03560	COG1595	DNA-templated transcription, initiation
A6033_03570	COG0018	arginyl-trna synthetase
A6033_03580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6033_03585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6033_03590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6033_03595	COG2146	nitrite reductase [NAD(P)H] activity
A6033_03600	COG2116	formate transmembrane transporter activity
A6033_03605	COG1648	precorrin-2 dehydrogenase activity
A6033_03605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6033_03645	COG0210	DNA helicase
A6033_03650	COG1943	Transposase
A6033_03685	COG1280	lysine exporter protein (LysE YggA)
A6033_03720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6033_03735	COG1063	alcohol dehydrogenase
A6033_03740	COG3245	cytochrome
A6033_03750	COG0210	DNA helicase
A6033_03760	COG2166	iron-sulfur cluster assembly
A6033_03765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6033_03790	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A6033_03795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6033_03800	COG1739	Uncharacterized protein family UPF0029
A6033_03805	COG0006	proline dipeptidase activity
A6033_03810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6033_03815	COG1024	Enoyl-CoA hydratase
A6033_03815	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6033_03820	COG0183	Belongs to the thiolase family
A6033_03825	COG0745	RESPONSE REGULATOR receiver
A6033_03830	COG2205	protein histidine kinase activity
A6033_03845	COG0425	Belongs to the sulfur carrier protein TusA family
A6033_03850	COG0251	oxidation-reduction process
A6033_03855	COG2885	chlorophyll binding
A6033_03860	COG2818	Glycosylase
A6033_03865	COG0752	glycyl-tRNA synthetase alpha subunit
A6033_03870	COG0751	glycine-tRNA ligase activity
A6033_03880	COG2199	diguanylate cyclase activity
A6033_03880	COG2202	Pas domain
A6033_03880	COG2200	EAL domain
A6033_03905	COG2188	Transcriptional regulator
A6033_03920	COG1609	Transcriptional regulator
A6033_03930	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6033_03950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6033_03960	COG2960	long-chain fatty acid transporting porin activity
A6033_03965	COG5001	Diguanylate cyclase
A6033_03975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6033_03985	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6033_03990	COG3118	belongs to the thioredoxin family
A6033_03995	COG0513	Belongs to the DEAD box helicase family
A6033_04000	COG0248	Ppx GppA phosphatase
A6033_04010	COG0742	ribosomal rna small subunit methyltransferase
A6033_04025	COG3469	chitinase activity
A6033_04040	COG0084	hydrolase, TatD family'
A6033_04045	COG0805	protein transport
A6033_04050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6033_04055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6033_04065	COG3165	ubiquinone biosynthetic process from chorismate
A6033_04070	COG2226	methyltransferase
A6033_04075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6033_04080	COG0402	S-adenosylhomocysteine deaminase activity
A6033_04085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A6033_04125	COG0848	biopolymer transport protein
A6033_04130	COG0811	peptide transport
A6033_04145	COG2771	luxR family
A6033_04150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6033_04155	COG1349	DNA-binding transcription factor activity
A6033_04160	COG0745	RESPONSE REGULATOR receiver
A6033_04165	COG2205	protein histidine kinase activity
A6033_04175	COG4452	Inner membrane protein CreD
A6033_04180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6033_04185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6033_04190	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6033_04195	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6033_04200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6033_04205	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6033_04210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6033_04220	COG0356	it plays a direct role in the translocation of protons across the membrane
A6033_04230	COG1475	DNA binding
A6033_04235	COG1192	Involved in chromosome partitioning
A6033_04240	COG0357	Ribosomal RNA small subunit methyltransferase G
A6033_04245	COG0445	tRNA wobble uridine modification
A6033_04250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6033_04260	COG4615	Cyclic peptide transporter
A6033_04265	COG1120	ATPase activity
A6033_04270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6033_04280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6033_04285	COG0706	membrane insertase activity
A6033_04290	COG0594	ribonuclease P activity
A6033_04295	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6033_04315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6033_04320	COG0592	DNA-directed DNA polymerase activity
A6033_04330	COG0187	DNA topoisomerase II activity
A6033_04345	COG2378	regulation of single-species biofilm formation
A6033_04355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6033_04360	COG0071	Belongs to the small heat shock protein (HSP20) family
A6033_04365	COG0071	Belongs to the small heat shock protein (HSP20) family
A6033_04370	COG3977	Valine--pyruvate aminotransferase
A6033_04385	COG2814	Major facilitator Superfamily
A6033_04390	COG0745	RESPONSE REGULATOR receiver
A6033_04395	COG2205	protein histidine kinase activity
A6033_04415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6033_04420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_04420	COG4191	Histidine kinase
A6033_04425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6033_04430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6033_04435	COG1309	transcriptional regulator
A6033_04465	COG0561	phosphatase activity
A6033_04470	COG2267	carboxylic ester hydrolase activity
A6033_04475	COG0110	maltose O-acetyltransferase activity
A6033_04485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6033_04490	COG1758	RNA polymerase activity
A6033_04495	COG0194	GDP metabolic process
A6033_04505	COG0859	PFAM glycosyl transferase family 9
A6033_04510	COG3642	lipopolysaccharide core region biosynthetic process
A6033_04545	COG0589	response to stress
A6033_04550	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6033_04555	COG1528	Iron-storage protein
A6033_04560	COG2081	HI0933 family
A6033_04565	COG3275	phosphorelay sensor kinase activity
A6033_04570	COG3279	Response regulator of the LytR AlgR family
A6033_04575	COG2223	nitrite transmembrane transporter activity
A6033_04580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6033_04600	COG0583	DNA-binding transcription factor activity
A6033_04605	COG4206	TonB-dependent receptor
A6033_04645	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6033_04645	COG1042	CoA-binding domain protein
A6033_04645	COG0045	succinate-CoA ligase (ADP-forming) activity
A6033_04660	COG0583	DNA-binding transcription factor activity
A6033_04665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6033_04670	COG0166	Belongs to the GPI family
A6033_04675	COG0668	transmembrane transport
A6033_04680	COG1309	transcriptional regulator
A6033_04685	COG0756	dUTP diphosphatase activity
A6033_04690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6033_04695	COG2003	Belongs to the UPF0758 family
A6033_04700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6033_04705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6033_04715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6033_04720	COG2990	Protein conserved in bacteria
A6033_04725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6033_04730	COG0859	PFAM glycosyl transferase family 9
A6033_04735	COG0463	Glycosyl transferase, family 2
A6033_04740	COG0859	PFAM glycosyl transferase family 9
A6033_04745	COG1519	Transferase
A6033_04760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_04765	COG1609	Transcriptional regulator
A6033_04770	COG0604	alcohol dehydrogenase
A6033_04785	COG3161	chorismate lyase activity
A6033_04790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6033_04795	COG2937	Belongs to the GPAT DAPAT family
A6033_04800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6033_04815	COG0534	Mate efflux family protein
A6033_04820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6033_04825	COG2205	protein histidine kinase activity
A6033_04830	COG0745	RESPONSE REGULATOR receiver
A6033_04840	COG1045	serine acetyltransferase
A6033_04850	COG3074	FtsZ-dependent cytokinesis
A6033_04855	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A6033_04860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6033_04860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6033_04905	COG1609	Transcriptional regulator
A6033_04910	COG3250	beta-galactosidase activity
A6033_04915	COG2731	YhcH YjgK YiaL family protein
A6033_04920	COG0531	amino acid
A6033_04925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6033_04930	COG0531	amino acid
A6033_04935	COG0385	Bile acid
A6033_04960	COG0583	DNA-binding transcription factor activity
A6033_05045	COG3093	addiction module antidote protein HigA
A6033_05050	COG3549	Plasmid maintenance system killer
A6033_05060	COG1561	YicC-like family, N-terminal region
A6033_05065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6033_05070	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6033_05085	COG2203	Gaf domain
A6033_05085	COG5001	Diguanylate cyclase
A6033_05085	COG3706	GGDEF domain
A6033_05085	COG4251	negative regulation of phosphorylation
A6033_05090	COG3084	Protein conserved in bacteria
A6033_05105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6033_05115	COG1335	isochorismatase
A6033_05125	COG1683	Conserved Protein
A6033_05130	COG0204	Acyl-transferase
A6033_05135	COG0204	Acyl-transferase
A6033_05195	COG2129	metallophosphoesterase
A6033_05250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6033_05255	COG3013	Belongs to the UPF0304 family
A6033_05290	COG3978	acetolactate synthase activity
A6033_05295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6033_05300	COG0129	dihydroxy-acid dehydratase activity
A6033_05315	COG1309	transcriptional regulator
A6033_05325	COG2391	methyltransferase activity
A6033_05335	COG2962	Rard protein
A6033_05340	COG1012	belongs to the aldehyde dehydrogenase family
A6033_05345	COG1396	sequence-specific DNA binding
A6033_05360	COG0519	Catalyzes the synthesis of GMP from XMP
A6033_05360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6033_05370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6033_05390	COG1322	Protein conserved in bacteria
A6033_05395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6033_05400	COG2204	response regulator
A6033_05405	COG3852	Histidine kinase
A6033_05415	COG0174	glutamine synthetase
A6033_05425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6033_05430	COG0569	domain protein
A6033_05435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6033_05435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6033_05440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6033_05445	COG0242	peptide deformylase activity
A6033_05450	COG1652	LysM domain
A6033_05455	COG0758	DNA mediated transformation
A6033_05460	COG2922	Belongs to the Smg family
A6033_05465	COG0551	DNA topoisomerase type I activity
A6033_05475	COG0009	L-threonylcarbamoyladenylate synthase
A6033_05480	COG0408	coproporphyrinogen oxidase activity
A6033_05485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6033_05495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6033_05510	COG3078	GTPase activator activity
A6033_05520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6033_05545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6033_05550	COG1288	antiporter activity
A6033_05555	COG1438	arginine binding
A6033_05560	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6033_05565	COG0540	Belongs to the ATCase OTCase family
A6033_05580	COG0583	DNA-binding transcription factor activity
A6033_05600	COG2207	Transcriptional regulator
A6033_05605	COG1979	alcohol dehydrogenase
A6033_05610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6033_05615	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6033_05625	COG2964	Protein conserved in bacteria
A6033_05630	COG3681	Belongs to the UPF0597 family
A6033_05645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6033_05650	COG0564	pseudouridine synthase activity
A6033_05660	COG0542	response to heat
A6033_05665	COG2502	aspartate--ammonia ligase
A6033_05670	COG1522	sequence-specific DNA binding
A6033_05680	COG5413	integral membrane protein
A6033_05685	COG0517	IMP dehydrogenase activity
A6033_05685	COG0516	GMP reductase activity
A6033_05690	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_05710	COG2204	response regulator
A6033_05720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6033_05740	COG0745	RESPONSE REGULATOR receiver
A6033_05745	COG2205	protein histidine kinase activity
A6033_05755	COG0243	molybdopterin cofactor binding
A6033_05760	COG3005	denitrification pathway
A6033_05765	COG4191	Histidine kinase
A6033_05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_05775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6033_05795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6033_05800	COG0569	domain protein
A6033_05805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6033_05830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6033_05840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6033_05845	COG0250	Participates in transcription elongation, termination and antitermination
A6033_05850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6033_05855	COG0081	regulation of translation
A6033_05860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6033_05865	COG0222	ribosome binding
A6033_05870	COG0085	RNA polymerase activity
A6033_05875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6033_05880	COG2964	Protein conserved in bacteria
A6033_05890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6033_05895	COG2923	Belongs to the DsrF TusC family
A6033_05900	COG2168	tRNA wobble position uridine thiolation
A6033_05905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6033_05910	COG0049	tRNA binding
A6033_05915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6033_05920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6033_05925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6033_05970	COG3714	YhhN family
A6033_05995	COG1301	dicarboxylic acid transport
A6033_06015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6033_06030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6033_06045	COG1770	oligopeptidase
A6033_06060	COG4221	oxidoreductase activity
A6033_06070	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6033_06095	COG0742	ribosomal rna small subunit methyltransferase
A6033_06100	COG0552	protein localization to endoplasmic reticulum
A6033_06105	COG2884	Cell division ATP-binding protein ftsE
A6033_06110	COG2177	Part of the ABC transporter FtsEX involved in
A6033_06120	COG0288	reversible hydration of carbon dioxide
A6033_06125	COG2188	Transcriptional regulator
A6033_06130	COG1228	amidohydrolase
A6033_06135	COG0010	Belongs to the arginase family
A6033_06140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6033_06145	COG2986	histidine ammonia-lyase
A6033_06150	COG0387	Pfam Sodium calcium exchanger
A6033_06155	COG2200	EAL domain
A6033_06160	COG2199	diguanylate cyclase activity
A6033_06160	COG2200	EAL domain
A6033_06205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6033_06210	COG1459	type II secretion system
A6033_06255	COG1077	Cell shape determining protein MreB Mrl
A6033_06260	COG1792	Involved in formation and maintenance of cell shape
A6033_06265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6033_06270	COG0424	maF-like protein
A6033_06275	COG1530	ribonuclease E activity
A6033_06290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6033_06295	COG0312	modulator of DNA gyrase
A6033_06310	COG0477	Major facilitator Superfamily
A6033_06350	COG0189	ligase activity
A6033_06360	COG0745	RESPONSE REGULATOR receiver
A6033_06385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6033_06390	COG0352	thiamine-phosphate diphosphorylase activity
A6033_06395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6033_06400	COG2022	thiamine diphosphate biosynthetic process
A6033_06405	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6033_06425	COG0110	maltose O-acetyltransferase activity
A6033_06440	COG0814	amino acid
A6033_06475	COG0165	Argininosuccinate lyase
A6033_06480	COG0137	argininosuccinate synthase activity
A6033_06490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6033_06495	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6033_06505	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6033_06510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6033_06525	COG0583	DNA-binding transcription factor activity
A6033_06530	COG1380	Effector of murein hydrolase LrgA
A6033_06535	COG1346	cytolysis
A6033_06545	COG4667	esterase of the alpha-beta hydrolase superfamily
A6033_06555	COG1546	Belongs to the CinA family
A6033_06560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6033_06570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6033_06575	COG0527	aspartate kinase activity
A6033_06580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6033_06615	COG1686	Belongs to the peptidase S11 family
A6033_06620	COG0586	Pfam SNARE associated Golgi protein
A6033_06625	COG1253	flavin adenine dinucleotide binding
A6033_06630	COG0252	asparaginase activity
A6033_06650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6033_06650	COG1263	PTS System
A6033_06655	COG0366	Alpha amylase catalytic
A6033_06660	COG0110	maltose O-acetyltransferase activity
A6033_06670	COG0564	pseudouridine synthase activity
A6033_06705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6033_06705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6033_06720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6033_06725	COG0038	chloride channel
A6033_06735	COG0316	Belongs to the HesB IscA family
A6033_06740	COG1757	Na H antiporter
A6033_06780	COG0297	glycogen (starch) synthase activity
A6033_06785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6033_06790	COG2813	Specifically methylates the guanine in position
A6033_06800	COG3025	triphosphatase activity
A6033_06805	COG1392	Phosphate transport regulator
A6033_06810	COG0306	phosphate transporter
A6033_06820	COG0626	cystathionine gamma-synthase activity
A6033_06835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6033_06840	COG0814	amino acid
A6033_06845	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6033_06850	COG0494	nUDIX hydrolase
A6033_06855	COG1011	Hydrolase
A6033_06870	COG0110	maltose O-acetyltransferase activity
A6033_06875	COG3174	membrane
A6033_06880	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A6033_06890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A6033_06895	COG4208	sulfate ABC transporter
A6033_06900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6033_06905	COG0583	DNA-binding transcription factor activity
A6033_06910	COG3397	chitin binding
A6033_06935	COG1215	transferase activity, transferring glycosyl groups
A6033_06975	COG1328	CTP reductase activity
A6033_06980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6033_06995	COG1448	Aminotransferase
A6033_07035	COG0513	Belongs to the DEAD box helicase family
A6033_07065	COG3112	Uncharacterised protein family (UPF0231)
A6033_07070	COG3835	regulator
A6033_07075	COG2610	gluconate transmembrane transporter activity
A6033_07080	COG1929	Belongs to the glycerate kinase type-1 family
A6033_07095	COG0583	DNA-binding transcription factor activity
A6033_07100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6033_07110	COG1872	DUF167
A6033_07115	COG0762	integral membrane protein
A6033_07120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6033_07125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6033_07140	COG3022	response to hydroperoxide
A6033_07160	COG0347	Belongs to the P(II) protein family
A6033_07165	COG1840	ABC-type Fe3 transport system, periplasmic component
A6033_07175	COG3842	ATPase activity
A6033_07180	COG2837	iron assimilation
A6033_07185	COG1438	arginine binding
A6033_07190	COG1126	abc transporter atp-binding protein
A6033_07195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_07200	COG4215	(ABC) transporter
A6033_07205	COG4160	amino acid transport
A6033_07210	COG0039	L-malate dehydrogenase activity
A6033_07215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6033_07220	COG1017	nitric oxide dioxygenase activity
A6033_07220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6033_07230	COG4536	flavin adenine dinucleotide binding
A6033_07235	COG4137	Cytochrome C assembly protein
A6033_07240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6033_07245	COG0228	four-way junction DNA binding
A6033_07250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6033_07255	COG0336	Belongs to the RNA methyltransferase TrmD family
A6033_07260	COG0335	large ribosomal subunit rRNA binding
A6033_07270	COG3066	DNA modification
A6033_07275	COG1051	belongs to the nudix hydrolase family
A6033_07285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6033_07290	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6033_07295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6033_07310	COG0640	Transcriptional regulator
A6033_07315	COG0268	Binds directly to 16S ribosomal RNA
A6033_07325	COG0196	riboflavin kinase activity
A6033_07330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6033_07340	COG1047	Peptidyl-prolyl cis-trans
A6033_07380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6033_07380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6033_07395	COG1854	S-ribosylhomocysteine lyase activity
A6033_07405	COG0084	hydrolase, TatD family'
A6033_07410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6033_07420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6033_07425	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6033_07430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6033_07435	COG0813	purine-nucleoside phosphorylase activity
A6033_07460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6033_07475	COG0776	regulation of translation
A6033_07485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6033_07490	COG1914	H( )-stimulated, divalent metal cation uptake system
A6033_07495	COG0360	Binds together with S18 to 16S ribosomal RNA
A6033_07500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6033_07505	COG0359	binds to the 23S rRNA
A6033_07510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6033_07530	COG1064	alcohol dehydrogenase
A6033_07535	COG1238	metal cluster binding
A6033_07540	COG0612	Peptidase, M16
A6033_07545	COG2918	glutathione biosynthetic process
A6033_07550	COG1022	Amp-dependent synthetase and ligase
A6033_07560	COG0456	acetyltransferase
A6033_07575	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A6033_07580	COG0745	RESPONSE REGULATOR receiver
A6033_07580	COG3706	GGDEF domain
A6033_07585	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_07605	COG0583	DNA-binding transcription factor activity
A6033_07615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6033_07620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6033_07630	COG0673	inositol 2-dehydrogenase activity
A6033_07640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6033_07645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6033_07650	COG3036	rescue of stalled ribosome
A6033_07660	COG0138	bifunctional purine biosynthesis protein purh
A6033_07665	COG0151	Belongs to the GarS family
A6033_07685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6033_07695	COG1610	YqeY-like protein
A6033_07700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6033_07705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6033_07710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6033_07715	COG1027	Aspartate ammonia-lyase
A6033_07735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6033_07740	COG0459	protein refolding
A6033_07830	COG4991	sh3 domain protein
A6033_07840	COG2816	NAD+ diphosphatase activity
A6033_07845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6033_07850	COG1940	carbohydrate kinase activity
A6033_07855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6033_07860	COG0126	phosphoglycerate kinase activity
A6033_07865	COG0191	fructose-bisphosphate aldolase activity
A6033_07870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_07920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6033_07930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6033_07935	COG1595	DNA-templated transcription, initiation
A6033_07940	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6033_07945	COG3026	antisigma factor binding
A6033_07955	COG0481	GTPase activity
A6033_07960	COG0681	Belongs to the peptidase S26 family
A6033_07975	COG1381	Involved in DNA repair and RecF pathway recombination
A6033_07980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6033_07995	COG2350	Protein conserved in bacteria
A6033_08000	COG2917	probably involved in intracellular septation
A6033_08005	COG0076	glutamate decarboxylase activity
A6033_08010	COG1272	protein, Hemolysin III
A6033_08015	COG0569	domain protein
A6033_08015	COG2985	domain, Protein
A6033_08050	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6033_08070	COG1858	cytochrome C peroxidase
A6033_08080	COG2313	pseudouridylate synthase activity
A6033_08085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6033_08120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6033_08125	COG1765	OsmC-like protein
A6033_08140	COG3954	Phosphoribulokinase
A6033_08145	COG3089	Belongs to the UPF0270 family
A6033_08150	COG5001	Diguanylate cyclase
A6033_08150	COG4251	negative regulation of phosphorylation
A6033_08150	COG3706	GGDEF domain
A6033_08150	COG2203	Gaf domain
A6033_08155	COG0429	hydrolase of the alpha beta-hydrolase fold
A6033_08160	COG0784	Response regulator, receiver
A6033_08160	COG0835	chemotaxis
A6033_08170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A6033_08175	COG1047	Peptidyl-prolyl cis-trans
A6033_08190	COG0305	Participates in initiation and elongation during chromosome replication
A6033_08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6033_08200	COG0432	Pfam Uncharacterised protein family UPF0047
A6033_08205	COG3340	Belongs to the peptidase S51 family
A6033_08220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6033_08230	COG3721	Heme iron utilization protein
A6033_08235	COG0748	coenzyme F420 binding
A6033_08260	COG2814	Major facilitator Superfamily
A6033_08270	COG3655	Transcriptional regulator
A6033_08300	COG3397	chitin binding
A6033_08340	COG0784	Response regulator, receiver
A6033_08340	COG0835	chemotaxis
A6033_08345	COG2755	lipolytic protein G-D-S-L family
A6033_08350	COG4181	ATPase activity
A6033_08360	COG1090	epimerase
A6033_08365	COG2200	EAL domain
A6033_08370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6033_08375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6033_08380	COG3171	Protein conserved in bacteria
A6033_08385	COG2066	Belongs to the glutaminase family
A6033_08390	COG2897	thiosulfate sulfurtransferase activity
A6033_08405	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6033_08420	COG3610	response to peptide
A6033_08435	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6033_08440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6033_08445	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6033_08450	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6033_08460	COG0786	glutamate:sodium symporter activity
A6033_08465	COG0252	asparaginase activity
A6033_08470	COG3139	Protein of unknown function (DUF1315)
A6033_08490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6033_08495	COG0321	lipoyl(octanoyl) transferase activity
A6033_08500	COG2921	Belongs to the UPF0250 family
A6033_08505	COG1686	Belongs to the peptidase S11 family
A6033_08510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6033_08515	COG2951	lytic endotransglycosylase activity
A6033_08520	COG0772	Belongs to the SEDS family
A6033_08525	COG0768	penicillin binding
A6033_08530	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6033_08535	COG0799	negative regulation of ribosome biogenesis
A6033_08540	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6033_08555	COG0495	leucyl-tRNA aminoacylation
A6033_08560	COG2888	peptidyl-tyrosine sulfation
A6033_08565	COG0312	modulator of DNA gyrase
A6033_08570	COG0312	modulator of DNA gyrase
A6033_08575	COG0716	FMN binding
A6033_08585	COG1970	mechanosensitive ion channel activity
A6033_08600	COG0789	Transcriptional regulator
A6033_08610	COG4535	Mg2 and Co2 transporter CorC
A6033_08615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6033_08620	COG1702	phosphate starvation-inducible protein PhoH
A6033_08630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6033_08635	COG1335	isochorismatase
A6033_08645	COG3706	GGDEF domain
A6033_08650	COG0583	DNA-binding transcription factor activity
A6033_08675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6033_08685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6033_08695	COG0516	GMP reductase activity
A6033_08715	COG0642	Histidine kinase
A6033_08720	COG0745	RESPONSE REGULATOR receiver
A6033_08730	COG4221	oxidoreductase activity
A6033_08740	COG0318	PFAM AMP-dependent synthetase and ligase
A6033_08755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_08780	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6033_08785	COG0700	Nucleoside recognition
A6033_08790	COG3366	ferrous iron transmembrane transporter activity
A6033_08795	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6033_08800	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6033_08805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6033_08810	COG1053	succinate dehydrogenase
A6033_08820	COG0584	glycerophosphoryl diester phosphodiesterase
A6033_08825	COG1511	domain protein
A6033_08825	COG3264	Mechanosensitive ion channel
A6033_08835	COG0739	heme binding
A6033_08845	COG0583	DNA-binding transcription factor activity
A6033_08865	COG0583	DNA-binding transcription factor activity
A6033_08870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6033_08900	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6033_08905	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6033_08920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6033_08930	COG0180	Tryptophanyl-tRNA synthetase
A6033_08940	COG0512	Glutamine amidotransferase of anthranilate synthase
A6033_08945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6033_08955	COG1012	belongs to the aldehyde dehydrogenase family
A6033_08970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6033_08980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_08980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6033_08980	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6033_08980	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6033_08985	COG0366	Alpha amylase catalytic
A6033_09010	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6033_09020	COG0490	domain, Protein
A6033_09020	COG0471	metal ion transport
A6033_09070	COG0012	GTP binding
A6033_09075	COG0193	aminoacyl-tRNA hydrolase activity
A6033_09080	COG0737	Belongs to the 5'-nucleotidase family
A6033_09085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6033_09095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6033_09100	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6033_09105	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6033_09110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6033_09125	COG2912	Transglutaminase-like superfamily
A6033_09130	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6033_09135	COG1301	dicarboxylic acid transport
A6033_09150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6033_09165	COG2801	Transposase and inactivated derivatives
A6033_09170	COG3408	Glycogen debranching enzyme
A6033_09170	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A6033_09205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6033_09215	COG0583	DNA-binding transcription factor activity
A6033_09220	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_09225	COG0616	signal peptide processing
A6033_09230	COG2211	Major facilitator Superfamily
A6033_09235	COG3706	GGDEF domain
A6033_09240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6033_09250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6033_09280	COG3724	N-succinylarginine dihydrolase activity
A6033_09285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6033_09295	COG0840	transmembrane signaling receptor activity
A6033_09315	COG4608	Belongs to the ABC transporter superfamily
A6033_09320	COG0444	Belongs to the ABC transporter superfamily
A6033_09325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6033_09340	COG2205	protein histidine kinase activity
A6033_09340	COG0784	Response regulator, receiver
A6033_09370	COG3220	belongs to the UPF0276 family
A6033_09400	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6033_09405	COG1289	transmembrane transporter activity
A6033_09410	COG0303	'Molybdopterin
A6033_09415	COG0746	molybdenum cofactor guanylyltransferase activity
A6033_09425	COG4662	Binding-protein-dependent transport system inner membrane component
A6033_09440	COG3852	Histidine kinase
A6033_09450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6033_09485	COG3383	formate dehydrogenase (NAD+) activity
A6033_09485	COG3383	formate dehydrogenase (NAD+) activity
A6033_09490	COG0437	4 iron, 4 sulfur cluster binding
A6033_09510	COG0281	malic enzyme
A6033_09530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_09560	COG0837	glucose binding
A6033_09565	COG1737	Transcriptional regulator
A6033_09570	COG0469	pyruvate kinase activity
A6033_09590	COG1677	Flagellar hook-basal body complex protein FliE
A6033_09600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6033_09650	COG1987	bacterial-type flagellum assembly
A6033_09655	COG1684	flagellar biosynthetic protein fliR
A6033_09665	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6033_09675	COG0455	bacterial-type flagellum organization
A6033_09690	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6033_09700	COG2201	protein-glutamate methylesterase activity
A6033_09710	COG1360	Flagellar Motor Protein
A6033_09715	COG1192	Involved in chromosome partitioning
A6033_09725	COG0835	chemotaxis
A6033_09740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6033_09745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6033_09750	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6033_09755	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6033_09760	COG1138	Cytochrome C-type biogenesis protein
A6033_09765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6033_09770	COG4235	cytochrome complex assembly
A6033_09770	COG3088	subunit of a heme lyase
A6033_09780	COG2853	Lipoprotein
A6033_09790	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6033_09795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6033_09805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6033_09810	COG1882	Formate acetyltransferase
A6033_09820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6033_09820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6033_09825	COG0259	pyridoxamine-phosphate oxidase activity
A6033_09830	COG0625	glutathione transferase activity
A6033_09850	COG2850	peptidyl-arginine hydroxylation
A6033_09855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6033_09860	COG2915	High frequency lysogenization protein hflD homolog
A6033_09865	COG0482	sulfurtransferase activity
A6033_09880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_09880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_09880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_09885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_09895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_09895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_09895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_09910	COG4821	SIS domain
A6033_09930	COG4792	protein secretion
A6033_09935	COG4791	protein targeting
A6033_09940	COG4794	Type iii secretion
A6033_09945	COG4790	Type iii secretion
A6033_09950	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6033_09990	COG0457	Tetratricopeptide repeat
A6033_10015	COG0457	Tetratricopeptide repeat
A6033_10105	COG1317	bacterial-type flagellum organization
A6033_10110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6033_10125	COG1960	acyl-CoA dehydrogenase activity
A6033_10135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A6033_10170	COG0457	Tetratricopeptide repeat
A6033_10175	COG0477	Major facilitator Superfamily
A6033_10175	COG2814	Major facilitator Superfamily
A6033_10185	COG3383	formate dehydrogenase (NAD+) activity
A6033_10245	COG4974	Belongs to the 'phage' integrase family
A6033_10265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6033_10270	COG2867	negative regulation of translational initiation
A6033_10280	COG1473	amidohydrolase
A6033_10285	COG1960	acyl-CoA dehydrogenase activity
A6033_10290	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6033_10295	COG0121	glutamine amidotransferase
A6033_10325	COG2197	response regulator
A6033_10330	COG3850	Histidine kinase
A6033_10335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6033_10340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6033_10350	COG0243	molybdopterin cofactor binding
A6033_10375	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6033_10380	COG0315	cyclic pyranopterin monophosphate synthase activity
A6033_10385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6033_10390	COG0314	molybdopterin synthase activity
A6033_10425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6033_10435	COG0302	gtp cyclohydrolase
A6033_10440	COG0840	transmembrane signaling receptor activity
A6033_10445	COG0840	transmembrane signaling receptor activity
A6033_10460	COG0583	DNA-binding transcription factor activity
A6033_10465	COG2353	YceI-like domain
A6033_10490	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6033_10495	COG1166	arginine decarboxylase activity
A6033_10525	COG0814	amino acid
A6033_10535	COG3681	Belongs to the UPF0597 family
A6033_10540	COG2964	Protein conserved in bacteria
A6033_10555	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6033_10565	COG0436	Aminotransferase
A6033_10575	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6033_10595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6033_10605	COG0788	formyltetrahydrofolate deformylase activity
A6033_10610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6033_10620	COG3118	belongs to the thioredoxin family
A6033_10625	COG2091	lysine biosynthetic process via aminoadipic acid
A6033_10630	COG0791	NLP P60 protein
A6033_10635	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
A6033_10645	COG0471	metal ion transport
A6033_10655	COG1388	LysM domain
A6033_10655	COG1376	ErfK ybiS ycfS ynhG family protein
A6033_10680	COG5002	protein histidine kinase activity
A6033_10705	COG0741	lytic transglycosylase activity
A6033_10705	COG1388	LysM domain
A6033_10710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6033_10715	COG2226	methyltransferase
A6033_10720	COG0328	RNA-DNA hybrid ribonuclease activity
A6033_10725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6033_10735	COG0784	Response regulator, receiver
A6033_10735	COG3437	response regulator, receiver
A6033_10740	COG2375	cellular response to nickel ion
A6033_10745	COG4771	TonB-dependent receptor
A6033_10750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6033_10755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6033_10760	COG1120	ATPase activity
A6033_10765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6033_10780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6033_10815	COG0708	Exodeoxyribonuclease III
A6033_10845	COG3132	Protein of unknown function, DUF480
A6033_10850	COG5001	Diguanylate cyclase
A6033_10850	COG3300	MHYT domain
A6033_10860	COG2841	Protein conserved in bacteria
A6033_10870	COG0534	Mate efflux family protein
A6033_10900	COG1309	transcriptional regulator
A6033_10935	COG3152	Membrane
A6033_10955	COG3537	Alpha-1,2-mannosidase
A6033_10970	COG3537	Alpha-1,2-mannosidase
A6033_10980	COG2207	Transcriptional regulator
A6033_10985	COG0538	isocitrate dehydrogenase activity
A6033_10990	COG3048	D-serine ammonia-lyase activity
A6033_10995	COG2610	gluconate transmembrane transporter activity
A6033_11000	COG0583	DNA-binding transcription factor activity
A6033_11005	COG0791	NLP P60 protein
A6033_11010	COG0583	DNA-binding transcription factor activity
A6033_11015	COG0450	alkyl hydroperoxide reductase
A6033_11040	COG0500	methyltransferase
A6033_11045	COG4106	trans-aconitate 2-methyltransferase activity
A6033_11050	COG1801	Protein of unknown function DUF72
A6033_11055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6033_11060	COG0217	transcriptional regulatory protein
A6033_11065	COG1012	belongs to the aldehyde dehydrogenase family
A6033_11065	COG1454	alcohol dehydrogenase
A6033_11070	COG2095	MarC family integral membrane protein
A6033_11080	COG0601	transmembrane transport
A6033_11085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6033_11100	COG0861	Integral membrane protein TerC family
A6033_11105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6033_11140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6033_11145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6033_11150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6033_11155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6033_11190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6033_11230	COG0346	lactoylglutathione lyase activity
A6033_11235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6033_11245	COG4659	FMN binding
A6033_11250	COG4658	electron transport chain
A6033_11260	COG2878	Part of a membrane complex involved in electron transport
A6033_11265	COG4657	Part of a membrane complex involved in electron transport
A6033_11270	COG1061	Type III restriction enzyme res subunit
A6033_11290	COG1187	pseudouridine synthase activity
A6033_11295	COG2807	transmembrane transport
A6033_11300	COG0583	DNA-binding transcription factor activity
A6033_11305	COG1607	acyl-coa hydrolase
A6033_11310	COG2979	Protein of unknown function (DUF533)
A6033_11315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6033_11325	COG1294	oxidase, subunit
A6033_11345	COG3220	belongs to the UPF0276 family
A6033_11360	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6033_11365	COG2814	Major facilitator Superfamily
A6033_11395	COG0583	DNA-binding transcription factor activity
A6033_11405	COG0840	transmembrane signaling receptor activity
A6033_11410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6033_11415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6033_11420	COG2271	Major facilitator Superfamily
A6033_11425	COG1349	DNA-binding transcription factor activity
A6033_11435	COG0584	glycerophosphoryl diester phosphodiesterase
A6033_11440	COG4574	serine-type endopeptidase inhibitor activity
A6033_11445	COG3085	chromosome segregation
A6033_11450	COG0583	DNA-binding transcription factor activity
A6033_11460	COG1448	Aminotransferase
A6033_11475	COG2333	competence protein COMEC
A6033_11475	COG0658	competence protein
A6033_11490	COG2835	tetraacyldisaccharide 4'-kinase activity
A6033_11495	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6033_11500	COG2197	response regulator
A6033_11505	COG0322	excinuclease ABC activity
A6033_11545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6033_11555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6033_11560	COG0215	cysteine-tRNA ligase activity
A6033_11565	COG0556	nucleotide-excision repair
A6033_11600	COG2119	membrane
A6033_11605	COG0023	Translation Initiation Factor
A6033_11640	COG0493	'glutamate synthase
A6033_11645	COG0067	glutamate synthase
A6033_11645	COG0069	glutamate synthase activity
A6033_11645	COG0070	glutamate synthase
A6033_11650	COG1242	4 iron, 4 sulfur cluster binding
A6033_11700	COG3634	alkyl hydroperoxide reductase activity
A6033_11705	COG0450	alkyl hydroperoxide reductase
A6033_11710	COG0517	IMP dehydrogenase activity
A6033_11715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6033_11720	COG0343	queuine tRNA-ribosyltransferase activity
A6033_11725	COG1862	Preprotein translocase
A6033_11730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6033_11790	COG1104	cysteine desulfurase activity
A6033_11795	COG0822	iron-sulfur transferase activity
A6033_11805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6033_11810	COG0443	Heat shock 70 kDa protein
A6033_11815	COG0633	Ferredoxin
A6033_11830	COG0105	UTP biosynthetic process
A6033_11835	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6033_11855	COG0124	histidyl-tRNA synthetase
A6033_11860	COG2976	Protein conserved in bacteria
A6033_11865	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6033_11870	COG1160	GTP binding
A6033_11875	COG1645	bacterial-type flagellum-dependent swarming motility
A6033_11880	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6033_11885	COG0047	phosphoribosylformylglycinamidine synthase activity
A6033_11885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6033_11890	COG2199	diguanylate cyclase activity
A6033_11890	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6033_11905	COG1007	ATP synthesis coupled electron transport
A6033_11910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_11920	COG0713	ATP synthesis coupled electron transport
A6033_11930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_11935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6033_11940	COG1034	ATP synthesis coupled electron transport
A6033_11955	COG0649	NAD binding
A6033_11955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_11960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_11965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_11990	COG4771	TonB-dependent receptor
A6033_12000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6033_12015	COG2963	transposase activity
A6033_12065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A6033_12075	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6033_12085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_12095	COG1126	abc transporter atp-binding protein
A6033_12105	COG0724	RNA recognition motif
A6033_12110	COG4989	oxidoreductase activity
A6033_12135	COG3437	response regulator, receiver
A6033_12140	COG0583	DNA-binding transcription factor activity
A6033_12145	COG5001	Diguanylate cyclase
A6033_12145	COG3300	MHYT domain
A6033_12150	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6033_12185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6033_12195	COG0539	negative regulation of cytoplasmic translation
A6033_12200	COG0776	regulation of translation
A6033_12210	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6033_12230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6033_12235	COG0602	queuosine metabolic process
A6033_12240	COG3530	Putative quorum-sensing-regulated virulence factor
A6033_12250	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6033_12255	COG1757	Na H antiporter
A6033_12260	COG1435	thymidine kinase activity
A6033_12280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6033_12285	COG0326	Molecular chaperone. Has ATPase activity
A6033_12290	COG4172	Belongs to the ABC transporter superfamily
A6033_12295	COG4172	Belongs to the ABC transporter superfamily
A6033_12300	COG4171	peptide transport system, permease
A6033_12305	COG4168	peptide transport system, permease
A6033_12320	COG1842	Phage shock protein A
A6033_12340	COG3768	UPF0283 membrane protein
A6033_12350	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6033_12355	COG2154	pterin-4-alpha-carbinolamine dehydratase
A6033_12370	COG2199	diguanylate cyclase activity
A6033_12375	COG2885	chlorophyll binding
A6033_12380	COG0861	Integral membrane protein TerC family
A6033_12435	COG1335	isochorismatase
A6033_12445	COG0583	DNA-binding transcription factor activity
A6033_12450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6033_12460	COG0583	DNA-binding transcription factor activity
A6033_12470	COG1944	ATP diphosphatase activity
A6033_12475	COG2116	formate transmembrane transporter activity
A6033_12480	COG1882	Formate acetyltransferase
A6033_12490	COG4166	transmembrane transport
A6033_12495	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6033_12500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6033_12515	COG1136	(ABC) transporter
A6033_12520	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6033_12525	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6033_12535	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6033_12540	COG0740	serine-type endopeptidase activity
A6033_12545	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6033_12550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6033_12555	COG0776	regulation of translation
A6033_12560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6033_12565	COG0488	(ABC) transporter
A6033_12570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6033_12575	COG3162	membrane
A6033_12590	COG1024	Enoyl-CoA hydratase
A6033_12595	COG1115	amino acid carrier protein
A6033_12610	COG1584	GPR1 FUN34 yaaH family protein
A6033_12640	COG1024	Enoyl-CoA hydratase
A6033_12650	COG1960	acyl-CoA dehydrogenase activity
A6033_12655	COG1960	acyl-CoA dehydrogenase activity
A6033_12660	COG1024	Enoyl-CoA hydratase
A6033_12665	COG1024	Enoyl-CoA hydratase
A6033_12675	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_12685	COG0730	response to heat
A6033_12760	COG1025	Belongs to the peptidase M16 family
A6033_12765	COG2062	phosphohistidine phosphatase, SixA
A6033_12775	COG0697	spore germination
A6033_12790	COG0058	SHG alpha-glucan phosphorylase activity
A6033_12795	COG0471	metal ion transport
A6033_12800	COG3118	belongs to the thioredoxin family
A6033_12810	COG1132	(ABC) transporter
A6033_12815	COG1132	(ABC) transporter
A6033_12825	COG2501	S4 domain
A6033_12840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6033_12865	COG0456	acetyltransferase
A6033_12880	COG2009	succinate dehydrogenase
A6033_12885	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6033_12890	COG1053	succinate dehydrogenase
A6033_12900	COG0567	Dehydrogenase, E1 component
A6033_12905	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6033_12910	COG0045	succinate-CoA ligase (ADP-forming) activity
A6033_12930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_12940	COG3842	ATPase activity
A6033_12945	COG1840	ABC-type Fe3 transport system, periplasmic component
A6033_12955	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6033_12965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6033_12990	COG1138	Cytochrome C-type biogenesis protein
A6033_12995	COG3301	Polysulphide reductase, NrfD
A6033_13000	COG0437	4 iron, 4 sulfur cluster binding
A6033_13005	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6033_13020	COG0247	lactate metabolic process
A6033_13025	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
A6033_13030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6033_13035	COG3012	SEC-C Motif Domain Protein
A6033_13040	COG0840	transmembrane signaling receptor activity
A6033_13060	COG0583	DNA-binding transcription factor activity
A6033_13075	COG3593	DNA synthesis involved in DNA repair
A6033_13130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6033_13135	COG1011	Hydrolase
A6033_13150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6033_13155	COG2832	Protein of unknown function (DUF454)
A6033_13160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6033_13170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6033_13180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6033_13195	COG1560	Kdo2-lipid A biosynthetic process
A6033_13200	COG1560	Kdo2-lipid A biosynthetic process
A6033_13240	COG1451	nucleotide metabolic process
A6033_13255	COG3069	C4-dicarboxylate transmembrane transporter activity
A6033_13270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_13270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6033_13275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6033_13280	COG2985	domain, Protein
A6033_13280	COG0569	domain protein
A6033_13300	COG0586	Pfam SNARE associated Golgi protein
A6033_13305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6033_13310	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6033_13320	COG4681	YaeQ
A6033_13365	COG0534	Mate efflux family protein
A6033_13375	COG0307	riboflavin synthase, alpha
A6033_13380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6033_13385	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6033_13390	COG0697	spore germination
A6033_13395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6033_13435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6033_13455	COG0850	regulation of cytokinetic process
A6033_13460	COG3100	YcgL domain-containing protein
A6033_13465	COG1760	l-serine dehydratase
A6033_13470	COG1760	l-serine dehydratase
A6033_13475	COG3123	guanosine phosphorylase activity
A6033_13480	COG1301	dicarboxylic acid transport
A6033_13485	COG0205	6-phosphofructokinase activity
A6033_13495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6033_13500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6033_13520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6033_13535	COG0242	peptide deformylase activity
A6033_13565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6033_13570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6033_13575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6033_13585	COG0549	Belongs to the carbamate kinase family
A6033_13590	COG0697	spore germination
A6033_13600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6033_13605	COG2068	MobA-Related Protein
A6033_13610	COG0493	'glutamate synthase
A6033_13610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6033_13615	COG0402	S-adenosylhomocysteine deaminase activity
A6033_13620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6033_13630	COG2233	PERMEase
A6033_13635	COG0402	S-adenosylhomocysteine deaminase activity
A6033_13640	COG2252	PERMEase
A6033_13645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A6033_13650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A6033_13655	COG2080	2 iron, 2 sulfur cluster binding
A6033_13660	COG3134	Outer membrane lipoprotein
A6033_13680	COG3706	GGDEF domain
A6033_13695	COG0107	imidazoleglycerol-phosphate synthase activity
A6033_13700	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6033_13705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6033_13710	COG0131	Imidazoleglycerol-phosphate dehydratase
A6033_13710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6033_13715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6033_13720	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6033_13725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6033_13740	COG1214	PFAM Peptidase M22, glycoprotease
A6033_13750	COG2267	carboxylic ester hydrolase activity
A6033_13755	COG0318	PFAM AMP-dependent synthetase and ligase
A6033_13765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6033_13790	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6033_13795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_13800	COG0840	transmembrane signaling receptor activity
A6033_13815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6033_13815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6033_13820	COG0489	protein tyrosine kinase activity
A6033_13825	COG0572	uridine kinase
A6033_13830	COG0717	Belongs to the dCTP deaminase family
A6033_13835	COG0306	phosphate transporter
A6033_13850	COG1530	ribonuclease E activity
A6033_13865	COG0424	maF-like protein
A6033_13870	COG1399	metal-binding, possibly nucleic acid-binding protein
A6033_13875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6033_13880	COG0416	fatty acid biosynthetic process
A6033_13885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6033_13895	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_13900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6033_13905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6033_13910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6033_13915	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6033_13920	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6033_13925	COG0470	DNA polymerase III
A6033_13930	COG0084	hydrolase, TatD family'
A6033_13945	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6033_13945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6033_13950	COG3008	intermembrane lipid transfer
A6033_13965	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6033_13970	COG0372	Belongs to the citrate synthase family
A6033_14015	COG4221	oxidoreductase activity
A6033_14020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A6033_14025	COG3141	response to X-ray
A6033_14050	COG1067	ATP-dependent peptidase activity
A6033_14055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6033_14070	COG0116	Belongs to the methyltransferase superfamily
A6033_14070	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6033_14075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6033_14080	COG0254	rRNA binding
A6033_14105	COG0308	aminopeptidase N
A6033_14115	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6033_14120	COG1956	GAF domain-containing protein
A6033_14130	COG3278	Belongs to the heme-copper respiratory oxidase family
A6033_14145	COG2010	Cytochrome c
A6033_14155	COG2217	Heavy metal translocating P-type atpase
A6033_14170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6033_14175	COG0589	response to stress
A6033_14180	COG0037	tRNA processing
A6033_14200	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6033_14205	COG1177	transmembrane transport
A6033_14210	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6033_14215	COG0625	glutathione transferase activity
A6033_14220	COG1869	D-ribose catabolic process
A6033_14225	COG1129	ABC transporter
A6033_14230	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6033_14235	COG1879	ABC-type sugar transport system periplasmic component
A6033_14240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6033_14245	COG1609	Transcriptional regulator
A6033_14250	COG5001	Diguanylate cyclase
A6033_14250	COG3300	MHYT domain
A6033_14280	COG0776	regulation of translation
A6033_14285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6033_14285	COG0072	phenylalanine-tRNA ligase activity
A6033_14290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6033_14295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6033_14300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6033_14305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6033_14310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6033_14330	COG0366	Alpha amylase catalytic
A6033_14340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6033_14350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6033_14355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6033_14360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6033_14365	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6033_14370	COG3313	Fe-S protein
A6033_14375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_14375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_14375	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6033_14380	COG1105	Belongs to the carbohydrate kinase PfkB family
A6033_14385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_14385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_14390	COG1609	Transcriptional regulator
A6033_14395	COG0814	amino acid
A6033_14405	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A6033_14415	COG0513	Belongs to the DEAD box helicase family
A6033_14425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6033_14430	COG2890	protein-(glutamine-N5) methyltransferase activity
A6033_14435	COG2840	Smr protein MutS2
A6033_14440	COG3706	GGDEF domain
A6033_14445	COG0406	alpha-ribazole phosphatase activity
A6033_14465	COG2824	Alkylphosphonate utilization operon protein PhnA
A6033_14480	COG0494	nUDIX hydrolase
A6033_14485	COG0814	amino acid
A6033_14495	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6033_14500	COG0514	ATP-dependent DNA helicase (RecQ)
A6033_14505	COG2766	serine protein kinase
A6033_14510	COG2718	Belongs to the UPF0229 family
A6033_14515	COG2719	SpoVR family
A6033_14520	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6033_14520	COG1024	Enoyl-CoA hydratase
A6033_14530	COG0714	Associated with various cellular activities
A6033_14560	COG1595	DNA-templated transcription, initiation
A6033_14575	COG2067	long-chain fatty acid transport protein
A6033_14580	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6033_14595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6033_14605	COG1643	Atp-dependent helicase
A6033_14615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6033_14620	COG3119	arylsulfatase activity
A6033_14625	COG0714	Associated with various cellular activities
A6033_14640	COG2304	oxidoreductase activity
A6033_14645	COG2304	oxidoreductase activity
A6033_14675	COG2925	Exonuclease
A6033_14685	COG3345	alpha-galactosidase
A6033_14690	COG1380	Effector of murein hydrolase LrgA
A6033_14695	COG1346	cytolysis
A6033_14700	COG0295	cytidine deaminase activity
A6033_14705	COG3033	Beta-eliminating lyase
A6033_14715	COG3046	protein related to deoxyribodipyrimidine photolyase
A6033_14720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_14725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6033_14745	COG3383	formate dehydrogenase (NAD+) activity
A6033_14750	COG3383	formate dehydrogenase (NAD+) activity
A6033_14755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6033_14765	COG3158	transport of potassium into the cell
A6033_14770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6033_14775	COG0651	ATP synthesis coupled electron transport
A6033_14780	COG0650	Formate hydrogenlyase subunit 4
A6033_14785	COG3261	NADH dehydrogenase
A6033_14785	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A6033_14790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6033_14795	COG3260	NADH ubiquinone oxidoreductase 20
A6033_14805	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6033_14825	COG0298	carbon dioxide binding
A6033_14835	COG0309	Hydrogenase expression formation protein (HypE)
A6033_14840	COG0375	protein maturation
A6033_14860	COG1124	(ABC) transporter
A6033_14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6033_14875	COG0601	transmembrane transport
A6033_14885	COG1773	rubredoxin
A6033_14890	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6033_14895	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A6033_14900	COG5557	Pfam Polysulphide reductase, NrfD
A6033_14910	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6033_14930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6033_14930	COG0519	Catalyzes the synthesis of GMP from XMP
A6033_14935	COG0517	IMP dehydrogenase activity
A6033_14935	COG0516	GMP reductase activity
A6033_14940	COG3038	cytochrome b561
A6033_14945	COG1570	exodeoxyribonuclease VII activity
A6033_14950	COG2188	Transcriptional regulator
A6033_14955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_14955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6033_14955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_14960	COG0383	alpha-mannosidase activity
A6033_14965	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6033_14975	COG0386	Belongs to the glutathione peroxidase family
A6033_14980	COG0513	Belongs to the DEAD box helicase family
A6033_14995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6033_15000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6033_15005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6033_15025	COG0598	Magnesium transport protein CorA
A6033_15055	COG3300	MHYT domain
A6033_15055	COG5001	Diguanylate cyclase
A6033_15070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6033_15080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6033_15085	COG0563	adenylate kinase activity
A6033_15095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6033_15100	COG1286	toxin biosynthetic process
A6033_15105	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6033_15110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6033_15115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6033_15120	COG1674	ftsk spoiiie
A6033_15120	COG0531	amino acid
A6033_15130	COG0686	Belongs to the AlaDH PNT family
A6033_15135	COG0492	ferredoxin-NADP+ reductase activity
A6033_15140	COG3706	GGDEF domain
A6033_15145	COG3134	Outer membrane lipoprotein
A6033_15150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6033_15160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6033_15170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6033_15175	COG1278	Cold shock
A6033_15180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6033_15200	COG0745	RESPONSE REGULATOR receiver
A6033_15205	COG2205	protein histidine kinase activity
A6033_15215	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6033_15215	COG0392	lysyltransferase activity
A6033_15230	COG0438	transferase activity, transferring glycosyl groups
A6033_15235	COG0438	transferase activity, transferring glycosyl groups
A6033_15300	COG0438	transferase activity, transferring glycosyl groups
A6033_15305	COG1215	transferase activity, transferring glycosyl groups
A6033_15310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6033_15385	COG0659	secondary active sulfate transmembrane transporter activity
A6033_15420	COG0672	)-iron permease
A6033_15440	COG2814	Major facilitator Superfamily
A6033_15455	COG1136	(ABC) transporter
A6033_15475	COG0596	Alpha beta hydrolase
A6033_15495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6033_15505	COG0527	aspartate kinase activity
A6033_15515	COG1368	sulfuric ester hydrolase activity
A6033_15520	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6033_15525	COG4667	esterase of the alpha-beta hydrolase superfamily
A6033_15540	COG2221	Nitrite and sulphite reductase 4Fe-4S
A6033_15555	COG0393	Putative heavy-metal-binding
A6033_15560	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6033_15565	COG0285	dihydrofolate synthase activity
A6033_15570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6033_15585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6033_15590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6033_15595	COG0671	phosphoesterase, PA-phosphatase related
A6033_15600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6033_15605	COG2056	Na+-H+ antiporter family
A6033_15610	COG5001	Diguanylate cyclase
A6033_15610	COG3300	MHYT domain
A6033_15625	COG2050	protein possibly involved in aromatic compounds catabolism
A6033_15635	COG0277	FAD linked oxidase domain protein
A6033_15635	COG0247	lactate metabolic process
A6033_15645	COG1253	flavin adenine dinucleotide binding
A6033_15660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6033_15665	COG0647	UMP catabolic process
A6033_15670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6033_15670	COG4651	solute:proton antiporter activity
A6033_15680	COG0367	asparagine synthase
A6033_15690	COG3069	C4-dicarboxylate transmembrane transporter activity
A6033_15695	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6033_15705	COG0625	glutathione transferase activity
A6033_15730	COG0564	pseudouridine synthase activity
A6033_15735	COG4160	amino acid transport
A6033_15740	COG4215	(ABC) transporter
A6033_15745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_15755	COG2431	L-lysine efflux transmembrane transporter activity
A6033_15760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6033_15765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_15770	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
A6033_15780	COG1393	Belongs to the ArsC family
A6033_15790	COG4783	chaperone-mediated protein folding
A6033_15795	COG0425	Belongs to the sulfur carrier protein TusA family
A6033_15820	COG3842	ATPase activity
A6033_15830	COG1175	transmembrane transport
A6033_15840	COG3081	Nucleoid-associated protein
A6033_15845	COG3082	Protein of unknown function (DUF1414)
A6033_15850	COG3083	sulfuric ester hydrolase activity
A6033_15855	COG1464	Belongs to the NlpA lipoprotein family
A6033_15870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6033_15870	COG0574	Belongs to the PEP-utilizing enzyme family
A6033_15875	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6033_15910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6033_15910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A6033_15915	COG0509	glycine decarboxylation via glycine cleavage system
A6033_15920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A6033_15925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6033_15930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6033_15940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6033_15950	COG0243	molybdopterin cofactor binding
A6033_15955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6033_15960	COG0583	DNA-binding transcription factor activity
A6033_15965	COG2814	Major facilitator Superfamily
A6033_15970	COG0625	glutathione transferase activity
A6033_15980	COG0483	inositol monophosphate 1-phosphatase activity
A6033_15995	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6033_16010	COG1086	Polysaccharide biosynthesis protein
A6033_16015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6033_16025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6033_16030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6033_16035	COG2089	acid synthase
A6033_16065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_16070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_16085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6033_16085	COG0301	tRNA thio-modification
A6033_16120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6033_16165	COG0328	RNA-DNA hybrid ribonuclease activity
A6033_16190	COG4953	penicillin-binding protein 1C
A6033_16205	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6033_16210	COG5001	Diguanylate cyclase
A6033_16210	COG3300	MHYT domain
A6033_16215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6033_16225	COG1252	NADH dehydrogenase
A6033_16245	COG2354	Protein conserved in bacteria
A6033_16260	COG1301	dicarboxylic acid transport
A6033_16275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6033_16290	COG0537	adenosine 5'-monophosphoramidase activity
A6033_16325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6033_16330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6033_16340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6033_16345	COG1605	Chorismate mutase
A6033_16345	COG0287	Prephenate dehydrogenase
A6033_16365	COG0123	including yeast histone deacetylase and acetoin utilization protein
A6033_16370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6033_16375	COG1785	Belongs to the alkaline phosphatase family
A6033_16395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6033_16400	COG2197	response regulator
A6033_16410	COG2271	Major facilitator Superfamily
A6033_16415	COG2199	diguanylate cyclase activity
A6033_16415	COG2203	Gaf domain
A6033_16420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6033_16425	COG0765	amino acid transport
A6033_16430	COG1126	abc transporter atp-binding protein
A6033_16445	COG0531	amino acid
A6033_16460	COG1253	flavin adenine dinucleotide binding
A6033_16465	COG0704	Plays a role in the regulation of phosphate uptake
A6033_16475	COG0581	inorganic phosphate transmembrane transporter activity
A6033_16485	COG0590	tRNA wobble adenosine to inosine editing
A6033_16495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6033_16515	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6033_16520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6033_16525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6033_16530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6033_16535	COG2204	response regulator
A6033_16540	COG3852	Histidine kinase
A6033_16545	COG2204	response regulator
A6033_16555	COG2716	regulation of RNA biosynthetic process
A6033_16565	COG0248	Ppx GppA phosphatase
A6033_16570	COG2239	Acts as a magnesium transporter
A6033_16575	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6033_16585	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6033_16585	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6033_16590	COG1706	bacterial-type flagellum-dependent cell motility
A6033_16595	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6033_16600	COG4786	Flagellar basal body rod
A6033_16605	COG4787	bacterial-type flagellum-dependent cell motility
A6033_16615	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6033_16620	COG1558	bacterial-type flagellum-dependent cell motility
A6033_16625	COG1815	bacterial-type flagellum-dependent cell motility
A6033_16630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6033_16635	COG0784	Response regulator, receiver
A6033_16635	COG0835	chemotaxis
A6033_16640	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A6033_16655	COG0622	Phosphoesterase
A6033_16660	COG4166	transmembrane transport
A6033_16670	COG1187	pseudouridine synthase activity
A6033_16675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6033_16685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6033_16690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6033_16700	COG1349	DNA-binding transcription factor activity
A6033_16705	COG4166	transmembrane transport
A6033_16730	COG1278	Cold shock
A6033_16755	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A6033_16755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6033_16760	COG1028	Short-chain dehydrogenase reductase Sdr
A6033_16765	COG3433	isochorismatase activity
A6033_16765	COG1535	isochorismatase
A6033_16770	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6033_16780	COG4771	TonB-dependent receptor
A6033_16785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6033_16805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6033_16825	COG2911	Protein conserved in bacteria
A6033_16830	COG0729	surface antigen
A6033_16840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6033_16850	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A6033_16860	COG4134	Bacterial extracellular solute-binding protein
A6033_16870	COG4136	ATPase activity
A6033_16875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6033_16880	COG2951	lytic endotransglycosylase activity
A6033_16885	COG1846	Transcriptional regulator
A6033_16895	COG0033	Phosphoglucomutase
A6033_16900	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6033_16905	COG0596	Alpha beta hydrolase
A6033_16920	COG0716	FMN binding
A6033_16930	COG0735	belongs to the Fur family
A6033_16935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6033_16945	COG1263	PTS System
A6033_16945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6033_16945	COG2190	(PTS) system
A6033_16950	COG0363	glucosamine-6-phosphate deaminase activity
A6033_16955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6033_16960	COG1846	Transcriptional regulator
A6033_16960	COG1940	carbohydrate kinase activity
A6033_16970	COG2199	diguanylate cyclase activity
A6033_16970	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6033_16980	COG3279	Response regulator of the LytR AlgR family
A6033_16985	COG1966	Carbon starvation protein
A6033_16990	COG1566	PFAM secretion protein HlyD family protein
A6033_17000	COG2027	D-alanyl-D-alanine carboxypeptidase
A6033_17005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6033_17020	COG1607	acyl-coa hydrolase
A6033_17025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6033_17050	COG0633	Ferredoxin
A6033_17050	COG0633	Ferredoxin
A6033_17050	COG3217	Mosc domain protein beta barrel domain protein
A6033_17050	COG3217	Mosc domain protein beta barrel domain protein
A6033_17060	COG0501	Belongs to the peptidase M48B family
A6033_17065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6033_17070	COG1073	alpha beta
A6033_17070	COG2226	methyltransferase
A6033_17075	COG0156	8-amino-7-oxononanoate synthase activity
A6033_17080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6033_17085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6033_17100	COG0017	Asparaginyl-tRNA synthetase
A6033_17120	COG1473	amidohydrolase
A6033_17125	COG3069	C4-dicarboxylate transmembrane transporter activity
A6033_17135	COG1393	Belongs to the ArsC family
A6033_17145	COG1876	peptidase activity
A6033_17165	COG1280	lysine exporter protein (LysE YggA)
A6033_17195	COG0564	pseudouridine synthase activity
A6033_17205	COG1454	alcohol dehydrogenase
A6033_17255	COG4964	Belongs to the GSP D family
A6033_17285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6033_17290	COG0702	epimerase
A6033_17300	COG0095	Lipoate-protein ligase
A6033_17310	COG0577	efflux transmembrane transporter activity
A6033_17310	COG1136	(ABC) transporter
A6033_17315	COG1136	(ABC) transporter
A6033_17315	COG0577	efflux transmembrane transporter activity
A6033_17320	COG0577	efflux transmembrane transporter activity
A6033_17320	COG1136	(ABC) transporter
A6033_17325	COG1566	PFAM secretion protein HlyD family protein
A6033_17370	COG1285	pathogenesis
A6033_17400	COG0484	heat shock protein binding
A6033_17405	COG0443	Heat shock 70 kDa protein
A6033_17410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6033_17420	COG0497	DNA recombination
A6033_17425	COG1227	inorganic diphosphatase activity
A6033_17430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6033_17435	COG0577	efflux transmembrane transporter activity
A6033_17435	COG1136	(ABC) transporter
A6033_17440	COG1538	Outer membrane efflux protein
A6033_17455	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A6033_17460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6033_17495	COG0028	Belongs to the TPP enzyme family
A6033_17510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6033_17530	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6033_17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6033_17550	COG1309	transcriptional regulator
A6033_17565	COG1342	Belongs to the UPF0251 family
A6033_17585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6033_17605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6033_17610	COG0083	homoserine kinase activity
A6033_17620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6033_17625	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
A6033_17630	COG1946	Acyl-CoA thioesterase
A6033_17640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6033_17650	COG0009	L-threonylcarbamoyladenylate synthase
A6033_17660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6033_17670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6033_17680	COG0133	tryptophan synthase activity
A6033_17705	COG1988	membrane-bound metal-dependent
A6033_17730	COG0798	PFAM Bile acid sodium symporter
A6033_17760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6033_17770	COG0745	RESPONSE REGULATOR receiver
A6033_17785	COG4988	ABC transporter
A6033_17790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6033_17810	COG1720	tRNA m6t6A37 methyltransferase activity
A6033_17815	COG3038	cytochrome b561
A6033_17825	COG0745	RESPONSE REGULATOR receiver
A6033_17850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6033_17870	COG0531	amino acid
A6033_17880	COG0531	amino acid
A6033_17890	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6033_17915	COG0420	3'-5' exonuclease activity
A6033_17935	COG3384	dioxygenase
A6033_17945	COG0469	pyruvate kinase activity
A6033_17950	COG3264	Mechanosensitive ion channel
A6033_17950	COG1196	nuclear chromosome segregation
A6033_17960	COG3590	peptidase
A6033_17965	COG3706	GGDEF domain
A6033_17970	COG2190	(PTS) system
A6033_17980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6033_17985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6033_17990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6033_18005	COG2770	Histidine kinase
A6033_18005	COG3437	response regulator, receiver
A6033_18010	COG3409	Peptidoglycan-binding domain 1 protein
A6033_18010	COG3267	Type II secretory pathway component ExeA
A6033_18020	COG3031	protein transport across the cell outer membrane
A6033_18030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6033_18035	COG1459	type II secretion system
A6033_18040	COG2165	general secretion pathway protein
A6033_18050	COG2165	general secretion pathway protein
A6033_18055	COG4795	General secretion pathway protein
A6033_18060	COG3156	type II secretion system protein K
A6033_18070	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6033_18080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6033_18085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6033_18090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6033_18095	COG2723	6-phospho-beta-galactosidase activity
A6033_18100	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6033_18105	COG1917	Cupin 2, conserved barrel domain protein
A6033_18105	COG2169	Transcriptional regulator
A6033_18110	COG1486	melibiose metabolic process
A6033_18125	COG0670	Belongs to the BI1 family
A6033_18130	COG1289	transmembrane transporter activity
A6033_18135	COG2920	part of a sulfur-relay system
A6033_18140	COG0673	inositol 2-dehydrogenase activity
A6033_18145	COG0583	DNA-binding transcription factor activity
A6033_18170	COG1032	radical SAM domain protein
A6033_18180	COG1566	PFAM secretion protein HlyD family protein
A6033_18195	COG0531	amino acid
A6033_18225	COG0281	malic enzyme
A6033_18235	COG0534	Mate efflux family protein
A6033_18245	COG3706	GGDEF domain
A6033_18250	COG2233	PERMEase
A6033_18255	COG0095	Lipoate-protein ligase
A6033_18265	COG0019	diaminopimelate decarboxylase activity
A6033_18275	COG0678	peroxiredoxin activity
A6033_18300	COG0545	Peptidyl-prolyl cis-trans isomerase
A6033_18305	COG3142	Participates in the control of copper homeostasis
A6033_18320	COG4783	chaperone-mediated protein folding
A6033_18330	COG5002	protein histidine kinase activity
A6033_18335	COG0745	RESPONSE REGULATOR receiver
A6033_18340	COG0346	lactoylglutathione lyase activity
A6033_18345	COG3284	Transcriptional regulator
A6033_18350	COG1012	belongs to the aldehyde dehydrogenase family
A6033_18360	COG0697	spore germination
A6033_18385	COG1846	Transcriptional regulator
A6033_18390	COG1566	PFAM secretion protein HlyD family protein
A6033_18415	COG0602	queuosine metabolic process
A6033_18420	COG1328	CTP reductase activity
A6033_18430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6033_18435	COG3115	cell septum assembly
A6033_18450	COG2860	membrane
A6033_18460	COG3108	Peptidase M15
A6033_18465	COG2989	Protein conserved in bacteria
A6033_18480	COG0463	Glycosyl transferase, family 2
A6033_18495	COG0366	Alpha amylase catalytic
A6033_18540	COG3590	peptidase
A6033_18550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6033_18555	COG1982	Orn Lys Arg decarboxylase major
A6033_18560	COG0531	amino acid
A6033_18570	COG3710	Transcriptional regulator
A6033_18575	COG0531	amino acid
A6033_18595	COG0814	amino acid
A6033_18625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6033_18630	COG0739	heme binding
A6033_18635	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6033_18645	COG0251	oxidation-reduction process
A6033_18660	COG0583	DNA-binding transcription factor activity
A6033_18670	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6033_18685	COG3091	SprT-like family
A6033_18695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6033_18700	COG0189	ligase activity
A6033_18705	COG1678	Uncharacterized ACR, COG1678
A6033_18710	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6033_18715	COG3104	oligopeptide transport
A6033_18720	COG0583	DNA-binding transcription factor activity
A6033_18730	COG0714	Associated with various cellular activities
A6033_18745	COG1115	amino acid carrier protein
A6033_18750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6033_18760	COG0825	malonyl-CoA metabolic process
A6033_18770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6033_18775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6033_18780	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6033_18785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6033_18790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6033_18805	COG0750	zinc metalloprotease
A6033_18810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6033_18815	COG0575	Belongs to the CDS family
A6033_18825	COG0233	cytoplasmic translational termination
A6033_18830	COG0528	UMP kinase activity
A6033_18835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6033_18840	COG0052	Belongs to the universal ribosomal protein uS2 family
A6033_18845	COG0024	Methionine aminopeptidase
A6033_18855	COG2171	N-acyltransferase activity
A6033_18865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6033_18865	COG1263	PTS System
A6033_18890	COG3098	single-species biofilm formation
A6033_18915	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6033_18925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6033_18925	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6033_18935	COG3706	GGDEF domain
A6033_18940	COG1611	Belongs to the LOG family
A6033_18945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6033_18950	COG0473	3-isopropylmalate dehydrogenase activity
A6033_18965	COG2363	Small membrane protein
A6033_18975	COG0583	DNA-binding transcription factor activity
A6033_18980	COG0840	transmembrane signaling receptor activity
A6033_18985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6033_19000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6033_19005	COG1666	GTP binding
A6033_19015	COG2211	Major facilitator Superfamily
A6033_19020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6033_19030	COG2813	Specifically methylates the guanine in position
A6033_19035	COG0271	Belongs to the BolA IbaG family
A6033_19040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6033_19045	COG1805	sodium ion transport
A6033_19055	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6033_19060	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6033_19070	COG1477	protein flavinylation
A6033_19115	COG0300	oxidoreductase activity
A6033_19125	COG0415	Belongs to the DNA photolyase family
A6033_19130	COG0789	Transcriptional regulator
A6033_19135	COG3272	Protein of unknown function (DUF1722)
A6033_19165	COG0077	Prephenate dehydratase
A6033_19165	COG1605	Chorismate mutase
A6033_19195	COG5377	YqaJ viral recombinase family
A6033_19240	COG2003	Belongs to the UPF0758 family
A6033_19250	COG0602	queuosine metabolic process
A6033_19255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6033_19290	COG0514	ATP-dependent DNA helicase (RecQ)
A6033_19295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6033_19320	COG4771	TonB-dependent receptor
A6033_19380	COG2226	methyltransferase
A6033_19415	COG0840	transmembrane signaling receptor activity
A6033_19425	COG0300	oxidoreductase activity
A6033_19450	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6033_19490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6033_19495	COG0826	peptidase U32
A6033_19500	COG1280	lysine exporter protein (LysE YggA)
A6033_19540	COG0835	chemotaxis
A6033_19545	COG0840	transmembrane signaling receptor activity
A6033_19555	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6033_19560	COG2201	protein-glutamate methylesterase activity
A6033_19565	COG1185	polyribonucleotide nucleotidyltransferase activity
A6033_19575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6033_19580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6033_19585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6033_19590	COG0195	Participates in both transcription termination and antitermination
A6033_19595	COG0779	Required for maturation of 30S ribosomal subunits
A6033_19610	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6033_19615	COG0149	triose-phosphate isomerase activity
A6033_19620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6033_19625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6033_19630	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6033_19635	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6033_19640	COG1534	Rna-binding protein
A6033_19650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6033_19655	COG1360	Flagellar Motor Protein
A6033_19660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6033_19665	COG1722	exodeoxyribonuclease VII activity
A6033_19670	COG0142	geranyltranstransferase activity
A6033_19675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6033_19680	COG0737	Belongs to the 5'-nucleotidase family
A6033_19705	COG0545	Peptidyl-prolyl cis-trans isomerase
A6033_19715	COG2900	Belongs to the SlyX family
A6033_19740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6033_19745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6033_19750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6033_19755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6033_19770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6033_19770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6033_19775	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6033_19780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6033_19795	COG1879	ABC-type sugar transport system periplasmic component
A6033_19805	COG0745	RESPONSE REGULATOR receiver
A6033_19810	COG3005	denitrification pathway
A6033_19820	COG3381	protein complex oligomerization
A6033_19840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6033_19845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6033_19850	COG0511	ligase activity, forming carbon-carbon bonds
A6033_19855	COG0439	Biotin carboxylase
A6033_19865	COG4145	pantothenate transmembrane transporter activity
A6033_19870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6033_19870	COG2190	(PTS) system
A6033_19870	COG1263	PTS System
A6033_19880	COG0604	alcohol dehydrogenase
A6033_19885	COG2264	protein methyltransferase activity
A6033_19895	COG0778	Nitroreductase
A6033_19900	COG1902	pentaerythritol trinitrate reductase activity
A6033_19900	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6033_19905	COG0616	signal peptide processing
A6033_19925	COG0848	biopolymer transport protein
A6033_19930	COG0811	peptide transport
A6033_19935	COG0811	peptide transport
A6033_19945	COG4206	TonB-dependent receptor
A6033_19950	COG4174	ABC transporter (Permease)
A6033_19955	COG4239	(ABC) transporter, permease
A6033_19965	COG0444	Belongs to the ABC transporter superfamily
A6033_19970	COG4608	Belongs to the ABC transporter superfamily
A6033_19990	COG3416	Protein conserved in bacteria
A6033_20000	COG0741	lytic transglycosylase activity
A6033_20015	COG0488	(ABC) transporter
A6033_20025	COG2252	PERMEase
A6033_20030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6033_20035	COG0840	transmembrane signaling receptor activity
A6033_20045	COG1278	Cold shock
A6033_20085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6033_20090	COG1162	GTPase activity
A6033_20095	COG0688	phosphatidylethanolamine metabolic process
A6033_20100	COG4628	conserved protein (DUF2132)
A6033_20135	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6033_20140	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6033_20145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6033_20150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6033_20155	COG3178	'Phosphotransferase
A6033_20160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6033_20165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6033_20170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6033_20175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6033_20185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6033_20195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A6033_20210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6033_20215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6033_20225	COG0142	geranyltranstransferase activity
A6033_20230	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6033_20235	COG0330	HflC and HflK could
A6033_20240	COG0330	HflC and HflK could
A6033_20245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6033_20250	COG1923	regulation of RNA biosynthetic process
A6033_20255	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6033_20260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6033_20270	COG0802	atpase or kinase
A6033_20275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6033_20275	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6033_20295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6033_20300	COG2011	ABC-type metal ion transport system permease component
A6033_20305	COG1464	Belongs to the NlpA lipoprotein family
A6033_20315	COG0840	transmembrane signaling receptor activity
A6033_20335	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6033_20340	COG0784	Response regulator, receiver
A6033_20340	COG5002	protein histidine kinase activity
A6033_20340	COG2198	Histidine kinase
A6033_20375	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6033_20380	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6033_20385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6033_20390	COG2716	regulation of RNA biosynthetic process
A6033_20395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6033_20400	COG3013	Belongs to the UPF0304 family
A6033_20405	COG3092	negative regulation of chromosome organization
A6033_20410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6033_20420	COG1555	photosystem II stabilization
A6033_20425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6033_20430	COG3104	oligopeptide transport
A6033_20435	COG0745	RESPONSE REGULATOR receiver
A6033_20465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6033_20480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6033_20545	COG2003	Belongs to the UPF0758 family
A6033_20605	COG3311	Transcriptional regulator
A6033_20645	COG0440	acetolactate synthase activity
A6033_20650	COG0028	Belongs to the TPP enzyme family
A6033_20670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6033_20675	COG0473	3-isopropylmalate dehydrogenase activity
A6033_20680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6033_20700	COG4143	(ABC) transporter
A6033_20705	COG1178	ABC-type Fe3 transport system permease component
A6033_20710	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6033_20715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH