locus-tag	class	description
C0073_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0073_000010	COG0592	DNA-directed DNA polymerase activity
C0073_000020	COG0187	DNA topoisomerase II activity
C0073_000030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0073_000035	COG0071	Belongs to the small heat shock protein (HSP20) family
C0073_000040	COG0071	Belongs to the small heat shock protein (HSP20) family
C0073_000045	COG3977	Valine--pyruvate aminotransferase
C0073_000060	COG2814	Major facilitator Superfamily
C0073_000065	COG0745	RESPONSE REGULATOR receiver
C0073_000070	COG2205	protein histidine kinase activity
C0073_000095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0073_000100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_000100	COG4191	Histidine kinase
C0073_000105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0073_000110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_000115	COG1309	transcriptional regulator
C0073_000150	COG0561	phosphatase activity
C0073_000155	COG2267	carboxylic ester hydrolase activity
C0073_000165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0073_000170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0073_000175	COG1758	RNA polymerase activity
C0073_000180	COG0194	GDP metabolic process
C0073_000190	COG0859	PFAM glycosyl transferase family 9
C0073_000195	COG3642	lipopolysaccharide core region biosynthetic process
C0073_000235	COG0589	response to stress
C0073_000240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0073_000245	COG1528	Iron-storage protein
C0073_000250	COG2081	HI0933 family
C0073_000255	COG3275	phosphorelay sensor kinase activity
C0073_000260	COG3279	Response regulator of the LytR AlgR family
C0073_000265	COG2223	nitrite transmembrane transporter activity
C0073_000270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0073_000275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0073_000290	COG0583	DNA-binding transcription factor activity
C0073_000295	COG4206	TonB-dependent receptor
C0073_000330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0073_000335	COG2166	iron-sulfur cluster assembly
C0073_000340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C0073_000355	COG3245	cytochrome
C0073_000360	COG1063	alcohol dehydrogenase
C0073_000365	COG0156	8-amino-7-oxononanoate synthase activity
C0073_000375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0073_000395	COG3307	-O-antigen
C0073_000445	COG1280	lysine exporter protein (LysE YggA)
C0073_000495	COG4310	Domain of unknown function (DUF2172)
C0073_000500	COG0210	DNA helicase
C0073_000505	COG1744	ABC transporter substrate-binding protein PnrA-like
C0073_000510	COG3845	ABC transporter
C0073_000515	COG4603	Belongs to the binding-protein-dependent transport system permease family
C0073_000520	COG1079	Belongs to the binding-protein-dependent transport system permease family
C0073_000525	COG2239	Acts as a magnesium transporter
C0073_000530	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0073_000530	COG1648	precorrin-2 dehydrogenase activity
C0073_000535	COG2116	formate transmembrane transporter activity
C0073_000550	COG0842	Transport permease protein
C0073_000555	COG0842	Transport permease protein
C0073_000565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_000575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C0073_000580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0073_000590	COG0018	arginyl-trna synthetase
C0073_000600	COG1595	DNA-templated transcription, initiation
C0073_000615	COG2017	converts alpha-aldose to the beta-anomer
C0073_000620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C0073_000630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0073_000635	COG1609	Transcriptional regulator
C0073_000640	COG3250	beta-galactosidase activity
C0073_000665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0073_000680	COG3385	transposase activity
C0073_000685	COG0366	Alpha amylase catalytic
C0073_000700	COG0443	Heat shock 70 kDa protein
C0073_000705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0073_000710	COG3045	CreA protein
C0073_000730	COG0174	glutamine synthetase
C0073_000750	COG3842	ATPase activity
C0073_000755	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0073_000760	COG1177	transmembrane transport
C0073_000765	COG2258	MOSC domain
C0073_000785	COG2050	protein possibly involved in aromatic compounds catabolism
C0073_000790	COG0514	ATP-dependent DNA helicase (RecQ)
C0073_000800	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0073_000810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C0073_000815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0073_000830	COG0254	rRNA binding
C0073_000835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0073_000845	COG0702	epimerase
C0073_000850	COG0814	amino acid
C0073_000855	COG0281	malic enzyme
C0073_000860	COG1295	ribonuclease BN
C0073_000865	COG1490	D-aminoacyl-tRNA deacylase activity
C0073_000870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C0073_000875	COG0456	acetyltransferase
C0073_000885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0073_000890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0073_000895	COG2610	gluconate transmembrane transporter activity
C0073_000900	COG3265	gluconokinase activity
C0073_000905	COG0129	dihydroxy-acid dehydratase activity
C0073_000910	COG0800	Aldolase
C0073_000915	COG1609	Transcriptional regulator
C0073_000925	COG4942	peptidase
C0073_000930	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C0073_000935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0073_000940	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C0073_000945	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0073_000950	COG0316	Belongs to the HesB IscA family
C0073_000950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C0073_000955	COG1040	competence protein
C0073_000960	COG0596	Alpha beta hydrolase
C0073_000980	COG2183	response to ionizing radiation
C0073_000985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0073_001005	COG0051	transcription antitermination factor activity, RNA binding
C0073_001010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0073_001015	COG0088	Forms part of the polypeptide exit tunnel
C0073_001020	COG0089	rRNA binding
C0073_001025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0073_001030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0073_001035	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0073_001040	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0073_001045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0073_001050	COG0255	Belongs to the universal ribosomal protein uL29 family
C0073_001055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0073_001060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0073_001065	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0073_001070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0073_001075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0073_001080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0073_001090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0073_001095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0073_001100	COG1841	ribosomal large subunit assembly
C0073_001105	COG0200	Binds to the 23S rRNA
C0073_001110	COG0201	protein transport
C0073_001115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0073_001120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0073_001125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0073_001130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0073_001135	COG0202	RNA polymerase activity
C0073_001140	COG0203	ribosomal protein L17
C0073_001180	COG4771	TonB-dependent receptor
C0073_001185	COG3706	GGDEF domain
C0073_001215	COG0583	DNA-binding transcription factor activity
C0073_001220	COG1741	Belongs to the pirin family
C0073_001225	COG2259	Doxx family
C0073_001230	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C0073_001235	COG1074	ATP-dependent DNA helicase activity
C0073_001240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0073_001255	COG2801	Transposase and inactivated derivatives
C0073_001295	COG1175	transmembrane transport
C0073_001305	COG3842	ATPase activity
C0073_001335	COG2873	o-acetylhomoserine
C0073_001365	COG5380	lipid catabolic process
C0073_001375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0073_001430	COG2927	DNA polymerase III (CHI subunit)
C0073_001435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0073_001440	COG0795	lipopolysaccharide-transporting ATPase activity
C0073_001445	COG0795	lipopolysaccharide-transporting ATPase activity
C0073_001505	COG0582	viral genome integration into host DNA
C0073_001510	COG3385	transposase activity
C0073_001590	COG1494	fructose-1,6-bisphosphatase
C0073_001605	COG2959	enzyme of heme biosynthesis
C0073_001615	COG0181	hydroxymethylbilane synthase activity
C0073_001620	COG3072	Adenylate cyclase
C0073_001625	COG0400	carboxylic ester hydrolase activity
C0073_001630	COG1965	Belongs to the frataxin family
C0073_001640	COG0019	diaminopimelate decarboxylase activity
C0073_001645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0073_001660	COG1011	Hydrolase
C0073_001680	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0073_001685	COG3028	Belongs to the UPF0307 family
C0073_001690	COG0312	modulator of DNA gyrase
C0073_001695	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0073_001700	COG5007	Belongs to the BolA IbaG family
C0073_001710	COG2854	intermembrane phospholipid transfer
C0073_001715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0073_001720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0073_001725	COG1127	ABC transporter
C0073_001730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C0073_001730	COG0517	IMP dehydrogenase activity
C0073_001735	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0073_001740	COG3117	lipopolysaccharide transmembrane transporter activity
C0073_001745	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C0073_001750	COG1137	ATPase activity
C0073_001765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_001770	COG1660	Displays ATPase and GTPase activities
C0073_001775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_001805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0073_001810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0073_001820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0073_001825	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0073_001830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0073_001835	COG0723	plastoquinol--plastocyanin reductase activity
C0073_001840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0073_001845	COG2857	Cytochrome c1
C0073_001850	COG0625	glutathione transferase activity
C0073_001855	COG2969	positive regulation of protein catabolic process
C0073_001865	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0073_001870	COG0792	nuclease activity
C0073_001875	COG3107	peptidoglycan biosynthetic process
C0073_001880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0073_001905	COG1987	bacterial-type flagellum assembly
C0073_001925	COG5433	transposase activity
C0073_001935	COG1677	Flagellar hook-basal body complex protein FliE
C0073_001945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0073_001975	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C0073_001980	COG1815	bacterial-type flagellum-dependent cell motility
C0073_001995	COG1749	Flagellar hook protein flgE
C0073_002000	COG4787	bacterial-type flagellum-dependent cell motility
C0073_002005	COG4786	Flagellar basal body rod
C0073_002010	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C0073_002015	COG1706	bacterial-type flagellum-dependent cell motility
C0073_002025	COG4786	Flagellar basal body rod
C0073_002025	COG1256	bacterial-type flagellum assembly
C0073_002030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0073_002040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0073_002045	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C0073_002070	COG1191	sigma factor activity
C0073_002075	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0073_002090	COG1388	LysM domain
C0073_002090	COG0741	lytic transglycosylase activity
C0073_002100	COG2001	Belongs to the MraZ family
C0073_002105	COG0275	rRNA processing
C0073_002110	COG3116	cell division
C0073_002115	COG0768	penicillin binding
C0073_002125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0073_002130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0073_002135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0073_002140	COG0772	Belongs to the SEDS family
C0073_002145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0073_002150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0073_002160	COG0849	cell division
C0073_002165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0073_002170	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C0073_002180	COG0653	protein targeting
C0073_002185	COG0494	nUDIX hydrolase
C0073_002190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C0073_002205	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C0073_002210	COG1459	type II secretion system
C0073_002215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0073_002240	COG2186	Transcriptional regulator
C0073_002245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0073_002250	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0073_002265	COG0840	transmembrane signaling receptor activity
C0073_002270	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0073_002275	COG1049	propionate catabolic process, 2-methylcitrate cycle
C0073_002280	COG2200	EAL domain
C0073_002290	COG0523	cobalamin synthesis protein
C0073_002325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C0073_002330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0073_002355	COG3314	Sporulation integral membrane protein YlbJ
C0073_002375	COG0165	Argininosuccinate lyase
C0073_002380	COG0137	argininosuccinate synthase activity
C0073_002390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0073_002395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0073_002405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C0073_002410	COG0110	maltose O-acetyltransferase activity
C0073_002420	COG3706	GGDEF domain
C0073_002425	COG0814	amino acid
C0073_002430	COG3932	Exopolysaccharide synthesis, ExoD
C0073_002440	COG3706	GGDEF domain
C0073_002445	COG0004	ammonium transporteR
C0073_002450	COG3133	Outer membrane lipoprotein
C0073_002455	COG0456	acetyltransferase
C0073_002475	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C0073_002480	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C0073_002495	COG0671	phosphoesterase, PA-phosphatase related
C0073_002500	COG0628	permease
C0073_002510	COG0456	acetyltransferase
C0073_002515	COG3039	Transposase
C0073_002520	COG5433	transposase activity
C0073_002535	COG3284	Transcriptional regulator
C0073_002550	COG1461	Dihydroxyacetone kinase
C0073_002555	COG2376	Dihydroxyacetone kinase
C0073_002560	COG2252	PERMEase
C0073_002565	COG1278	Cold shock
C0073_002575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0073_002630	COG5433	transposase activity
C0073_002635	COG2801	Transposase and inactivated derivatives
C0073_002655	COG3300	MHYT domain
C0073_002655	COG5001	Diguanylate cyclase
C0073_002710	COG1388	LysM domain
C0073_002710	COG1470	cell adhesion involved in biofilm formation
C0073_002740	COG2197	response regulator
C0073_002775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0073_002785	COG3047	cAMP biosynthetic process
C0073_002790	COG0840	transmembrane signaling receptor activity
C0073_002815	COG3135	benzoate transporter
C0073_002820	COG1396	sequence-specific DNA binding
C0073_002855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0073_002855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0073_002870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0073_002875	COG0038	chloride channel
C0073_002885	COG0316	Belongs to the HesB IscA family
C0073_002890	COG1757	Na H antiporter
C0073_002930	COG0297	glycogen (starch) synthase activity
C0073_002935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C0073_002940	COG2813	Specifically methylates the guanine in position
C0073_002945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0073_002950	COG3025	triphosphatase activity
C0073_002955	COG1392	Phosphate transport regulator
C0073_002960	COG0306	phosphate transporter
C0073_002970	COG0527	aspartate kinase activity
C0073_002970	COG0460	homoserine dehydrogenase
C0073_002975	COG0626	cystathionine gamma-synthase activity
C0073_002990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0073_002995	COG0814	amino acid
C0073_003000	COG1218	3'(2'),5'-bisphosphate nucleotidase
C0073_003005	COG0494	nUDIX hydrolase
C0073_003010	COG1011	Hydrolase
C0073_003025	COG0110	maltose O-acetyltransferase activity
C0073_003030	COG3174	membrane
C0073_003035	COG3397	chitin binding
C0073_003040	COG0840	transmembrane signaling receptor activity
C0073_003070	COG0543	2 iron, 2 sulfur cluster binding
C0073_003070	COG0633	Ferredoxin
C0073_003095	COG1328	CTP reductase activity
C0073_003100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0073_003115	COG1448	Aminotransferase
C0073_003130	COG1842	Phage shock protein A
C0073_003145	COG2827	Endonuclease containing a URI domain
C0073_003160	COG1573	uracil-dna glycosylase
C0073_003165	COG0697	spore germination
C0073_003175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C0073_003180	COG1121	(ABC) transporter
C0073_003185	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C0073_003205	COG3039	Transposase
C0073_003215	COG0739	heme binding
C0073_003225	COG3068	Protein conserved in bacteria
C0073_003245	COG0617	tRNA 3'-terminal CCA addition
C0073_003250	COG1194	a g-specific adenine glycosylase
C0073_003255	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C0073_003265	COG3111	PFAM Bacterial OB fold (BOF) protein
C0073_003270	COG3240	lipase activity
C0073_003275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C0073_003275	COG2885	chlorophyll binding
C0073_003280	COG3706	GGDEF domain
C0073_003285	COG0557	exoribonuclease II activity
C0073_003290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0073_003300	COG2153	protein acetylation
C0073_003305	COG0513	Belongs to the DEAD box helicase family
C0073_003310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C0073_003335	COG0735	belongs to the Fur family
C0073_003340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0073_003345	COG0840	transmembrane signaling receptor activity
C0073_003355	COG4166	transmembrane transport
C0073_003365	COG0110	maltose O-acetyltransferase activity
C0073_003375	COG1024	Enoyl-CoA hydratase
C0073_003390	COG4221	oxidoreductase activity
C0073_003395	COG0442	prolyl-tRNA aminoacylation
C0073_003400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0073_003410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0073_003410	COG3008	intermembrane lipid transfer
C0073_003415	COG2995	paraquat-inducible protein a
C0073_003425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0073_003435	COG2203	Gaf domain
C0073_003435	COG3706	GGDEF domain
C0073_003435	COG5001	Diguanylate cyclase
C0073_003435	COG4251	negative regulation of phosphorylation
C0073_003440	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C0073_003455	COG2771	luxR family
C0073_003465	COG0840	transmembrane signaling receptor activity
C0073_003470	COG0632	four-way junction helicase activity
C0073_003475	COG2255	four-way junction helicase activity
C0073_003485	COG1294	oxidase, subunit
C0073_003490	COG4890	Cyd operon protein YbgT
C0073_003495	COG3790	cyd operon protein YbgE
C0073_003500	COG0824	Thioesterase
C0073_003505	COG0811	peptide transport
C0073_003520	COG0823	Involved in the tonB-independent uptake of proteins
C0073_003525	COG2885	chlorophyll binding
C0073_003530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C0073_003595	COG0733	neurotransmitter:sodium symporter activity
C0073_003605	COG0733	neurotransmitter:sodium symporter activity
C0073_003620	COG0561	phosphatase activity
C0073_003670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C0073_003675	COG1640	4-alpha-glucanotransferase
C0073_003685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0073_003690	COG0676	glucose-6-phosphate 1-epimerase activity
C0073_003695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0073_003700	COG0840	transmembrane signaling receptor activity
C0073_003705	COG1585	Membrane protein implicated in regulation of membrane protease activity
C0073_003710	COG0330	HflC and HflK could
C0073_003715	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0073_003715	COG1648	precorrin-2 dehydrogenase activity
C0073_003720	COG0175	sulfate reduction
C0073_003725	COG2895	sulfate adenylyltransferase (ATP) activity
C0073_003730	COG0471	metal ion transport
C0073_003730	COG3273	potassium ion transport
C0073_003735	COG0529	Catalyzes the synthesis of activated sulfate
C0073_003745	COG0840	transmembrane signaling receptor activity
C0073_003765	COG1136	(ABC) transporter
C0073_003780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C0073_003795	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0073_003800	COG3437	response regulator, receiver
C0073_003800	COG0784	Response regulator, receiver
C0073_003810	COG2076	Multidrug Resistance protein
C0073_003815	COG2076	Multidrug Resistance protein
C0073_003820	COG0346	lactoylglutathione lyase activity
C0073_003830	COG1643	Atp-dependent helicase
C0073_003840	COG1489	DNA binding
C0073_003845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0073_003850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0073_003860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0073_003865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0073_003870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0073_003880	COG1823	symporter activity
C0073_003900	COG1924	4 iron, 4 sulfur cluster binding
C0073_003905	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C0073_003910	COG0842	Transport permease protein
C0073_003915	COG1131	(ABC) transporter
C0073_003930	COG0163	prenyltransferase activity
C0073_003940	COG0671	phosphoesterase, PA-phosphatase related
C0073_003945	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0073_003955	COG1151	hydroxylamine reductase activity
C0073_003960	COG0783	Belongs to the Dps family
C0073_003980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0073_003985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0073_003990	COG3956	TIGRFAM MazG family protein
C0073_003995	COG0504	CTP synthase activity
C0073_004000	COG0148	phosphopyruvate hydratase activity
C0073_004040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0073_004050	COG0488	(ABC) transporter
C0073_004055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0073_004055	COG0617	tRNA 3'-terminal CCA addition
C0073_004055	COG0517	IMP dehydrogenase activity
C0073_004085	COG1794	racemase activity, acting on amino acids and derivatives
C0073_004095	COG2731	YhcH YjgK YiaL family protein
C0073_004105	COG0668	transmembrane transport
C0073_004110	COG1376	ErfK ybiS ycfS ynhG family protein
C0073_004120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0073_004125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0073_004130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0073_004140	COG0585	pseudouridine synthase activity
C0073_004145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C0073_004150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0073_004170	COG1902	pentaerythritol trinitrate reductase activity
C0073_004185	COG2957	Belongs to the agmatine deiminase family
C0073_004210	COG0513	Belongs to the DEAD box helicase family
C0073_004215	COG2203	Gaf domain
C0073_004215	COG2199	diguanylate cyclase activity
C0073_004225	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
C0073_004300	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0073_004305	COG2252	PERMEase
C0073_004315	COG0488	(ABC) transporter
C0073_004330	COG0741	lytic transglycosylase activity
C0073_004345	COG3416	Protein conserved in bacteria
C0073_004350	COG0583	DNA-binding transcription factor activity
C0073_004355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C0073_004360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0073_004365	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0073_004390	COG4608	Belongs to the ABC transporter superfamily
C0073_004395	COG0444	Belongs to the ABC transporter superfamily
C0073_004405	COG4239	(ABC) transporter, permease
C0073_004410	COG4174	ABC transporter (Permease)
C0073_004415	COG4206	TonB-dependent receptor
C0073_004425	COG0811	peptide transport
C0073_004430	COG0811	peptide transport
C0073_004435	COG0848	biopolymer transport protein
C0073_004465	COG0616	signal peptide processing
C0073_004475	COG0778	Nitroreductase
C0073_004485	COG2264	protein methyltransferase activity
C0073_004490	COG0604	alcohol dehydrogenase
C0073_004495	COG0583	DNA-binding transcription factor activity
C0073_004500	COG2190	(PTS) system
C0073_004500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0073_004500	COG1263	PTS System
C0073_004505	COG4145	pantothenate transmembrane transporter activity
C0073_004515	COG0439	Biotin carboxylase
C0073_004520	COG0511	ligase activity, forming carbon-carbon bonds
C0073_004525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0073_004530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0073_004550	COG3381	protein complex oligomerization
C0073_004560	COG3005	denitrification pathway
C0073_004565	COG0745	RESPONSE REGULATOR receiver
C0073_004575	COG1879	ABC-type sugar transport system periplasmic component
C0073_004580	COG0784	Response regulator, receiver
C0073_004580	COG2198	Histidine kinase
C0073_004580	COG2205	protein histidine kinase activity
C0073_004590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0073_004600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0073_004605	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0073_004605	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0073_004620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0073_004625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0073_004630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C0073_004635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0073_004650	COG0601	transmembrane transport
C0073_004660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0073_004665	COG0142	geranyltranstransferase activity
C0073_004670	COG1722	exodeoxyribonuclease VII activity
C0073_004675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0073_004680	COG1360	Flagellar Motor Protein
C0073_004695	COG1534	Rna-binding protein
C0073_004700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0073_004710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0073_004715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0073_004720	COG0149	triose-phosphate isomerase activity
C0073_004725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0073_004740	COG0779	Required for maturation of 30S ribosomal subunits
C0073_004745	COG0195	Participates in both transcription termination and antitermination
C0073_004750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0073_004755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0073_004760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0073_004765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0073_004770	COG1185	polyribonucleotide nucleotidyltransferase activity
C0073_004780	COG3655	Transcriptional regulator
C0073_004790	COG5002	protein histidine kinase activity
C0073_004790	COG0784	Response regulator, receiver
C0073_004790	COG2205	protein histidine kinase activity
C0073_004805	COG3706	GGDEF domain
C0073_004830	COG3397	chitin binding
C0073_004860	COG2755	lipolytic protein G-D-S-L family
C0073_004865	COG4181	ATPase activity
C0073_004875	COG1090	epimerase
C0073_004880	COG2200	EAL domain
C0073_004885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0073_004890	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0073_004895	COG3171	Protein conserved in bacteria
C0073_004900	COG2066	Belongs to the glutaminase family
C0073_004905	COG2897	thiosulfate sulfurtransferase activity
C0073_004920	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0073_004930	COG2966	Psort location CytoplasmicMembrane, score
C0073_004935	COG3610	response to peptide
C0073_004950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0073_004955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0073_004960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0073_004975	COG0786	glutamate:sodium symporter activity
C0073_004985	COG3139	Protein of unknown function (DUF1315)
C0073_005005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0073_005010	COG0321	lipoyl(octanoyl) transferase activity
C0073_005015	COG2921	Belongs to the UPF0250 family
C0073_005020	COG1686	Belongs to the peptidase S11 family
C0073_005025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0073_005040	COG0768	penicillin binding
C0073_005045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0073_005050	COG0799	negative regulation of ribosome biogenesis
C0073_005055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0073_005070	COG0495	leucyl-tRNA aminoacylation
C0073_005075	COG2888	peptidyl-tyrosine sulfation
C0073_005085	COG0312	modulator of DNA gyrase
C0073_005090	COG0312	modulator of DNA gyrase
C0073_005095	COG0716	FMN binding
C0073_005100	COG4974	Belongs to the 'phage' integrase family
C0073_005105	COG1970	mechanosensitive ion channel activity
C0073_005120	COG0789	Transcriptional regulator
C0073_005125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0073_005130	COG4535	Mg2 and Co2 transporter CorC
C0073_005135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0073_005140	COG1702	phosphate starvation-inducible protein PhoH
C0073_005145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0073_005155	COG1335	isochorismatase
C0073_005165	COG3706	GGDEF domain
C0073_005170	COG0583	DNA-binding transcription factor activity
C0073_005190	COG5001	Diguanylate cyclase
C0073_005190	COG3447	MASE1 domain protein
C0073_005190	COG5002	protein histidine kinase activity
C0073_005200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0073_005210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0073_005220	COG0516	GMP reductase activity
C0073_005230	COG0642	Histidine kinase
C0073_005245	COG4221	oxidoreductase activity
C0073_005255	COG1022	Amp-dependent synthetase and ligase
C0073_005270	COG3214	Protein conserved in bacteria
C0073_005280	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0073_005285	COG0700	Nucleoside recognition
C0073_005290	COG3366	ferrous iron transmembrane transporter activity
C0073_005295	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C0073_005300	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
C0073_005305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0073_005310	COG1053	succinate dehydrogenase
C0073_005320	COG0584	glycerophosphoryl diester phosphodiesterase
C0073_005325	COG1511	domain protein
C0073_005325	COG3264	Mechanosensitive ion channel
C0073_005335	COG0739	heme binding
C0073_005345	COG0583	DNA-binding transcription factor activity
C0073_005365	COG0583	DNA-binding transcription factor activity
C0073_005400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0073_005405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0073_005415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C0073_005420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0073_005430	COG0180	Tryptophanyl-tRNA synthetase
C0073_005440	COG0512	Glutamine amidotransferase of anthranilate synthase
C0073_005445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0073_005455	COG1012	belongs to the aldehyde dehydrogenase family
C0073_005470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0073_005480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_005480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0073_005480	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0073_005480	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0073_005485	COG0366	Alpha amylase catalytic
C0073_005505	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C0073_005515	COG0471	metal ion transport
C0073_005515	COG0490	domain, Protein
C0073_005570	COG0012	GTP binding
C0073_005575	COG0193	aminoacyl-tRNA hydrolase activity
C0073_005580	COG0737	Belongs to the 5'-nucleotidase family
C0073_005585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0073_005595	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0073_005600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0073_005605	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0073_005610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0073_005615	COG2890	protein-(glutamine-N5) methyltransferase activity
C0073_005625	COG2912	Transglutaminase-like superfamily
C0073_005630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C0073_005650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C0073_005665	COG1881	PFAM PEBP family protein
C0073_005670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0073_005685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C0073_005695	COG0583	DNA-binding transcription factor activity
C0073_005700	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_005705	COG0616	signal peptide processing
C0073_005715	COG2211	Major facilitator Superfamily
C0073_005720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0073_005730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0073_005735	COG0826	peptidase U32
C0073_005760	COG3724	N-succinylarginine dihydrolase activity
C0073_005775	COG0840	transmembrane signaling receptor activity
C0073_005785	COG2971	BadF BadG BcrA BcrD
C0073_005795	COG4608	Belongs to the ABC transporter superfamily
C0073_005800	COG0444	Belongs to the ABC transporter superfamily
C0073_005805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0073_005820	COG2205	protein histidine kinase activity
C0073_005820	COG0784	Response regulator, receiver
C0073_005850	COG3220	belongs to the UPF0276 family
C0073_005885	COG1289	transmembrane transporter activity
C0073_005895	COG0746	molybdenum cofactor guanylyltransferase activity
C0073_005905	COG4662	Binding-protein-dependent transport system inner membrane component
C0073_005915	COG2204	response regulator
C0073_005920	COG3852	Histidine kinase
C0073_005930	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0073_005965	COG3383	formate dehydrogenase (NAD+) activity
C0073_005965	COG3383	formate dehydrogenase (NAD+) activity
C0073_005970	COG0437	4 iron, 4 sulfur cluster binding
C0073_005990	COG0281	malic enzyme
C0073_006010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_006040	COG0837	glucose binding
C0073_006045	COG1737	Transcriptional regulator
C0073_006050	COG0469	pyruvate kinase activity
C0073_006070	COG1677	Flagellar hook-basal body complex protein FliE
C0073_006080	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0073_006130	COG1987	bacterial-type flagellum assembly
C0073_006135	COG1684	flagellar biosynthetic protein fliR
C0073_006145	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0073_006170	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C0073_006175	COG0784	Response regulator, receiver
C0073_006175	COG0643	Histidine kinase
C0073_006175	COG2198	Histidine kinase
C0073_006180	COG2201	protein-glutamate methylesterase activity
C0073_006185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0073_006190	COG1360	Flagellar Motor Protein
C0073_006195	COG1192	Involved in chromosome partitioning
C0073_006205	COG0835	chemotaxis
C0073_006220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0073_006225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0073_006230	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0073_006235	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C0073_006240	COG1138	Cytochrome C-type biogenesis protein
C0073_006245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0073_006250	COG3088	subunit of a heme lyase
C0073_006250	COG4235	cytochrome complex assembly
C0073_006260	COG2853	Lipoprotein
C0073_006270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0073_006275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0073_006285	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0073_006290	COG1882	Formate acetyltransferase
C0073_006300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0073_006300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0073_006305	COG0259	pyridoxamine-phosphate oxidase activity
C0073_006310	COG0625	glutathione transferase activity
C0073_006330	COG2850	peptidyl-arginine hydroxylation
C0073_006335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C0073_006340	COG2915	High frequency lysogenization protein hflD homolog
C0073_006345	COG0482	sulfurtransferase activity
C0073_006355	COG1187	pseudouridine synthase activity
C0073_006365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_006370	COG2271	Major facilitator Superfamily
C0073_006375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_006375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_006375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_006400	COG0783	Belongs to the Dps family
C0073_006430	COG1609	Transcriptional regulator
C0073_006435	COG1263	PTS System
C0073_006435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0073_006445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0073_006455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0073_006460	COG1960	acyl-CoA dehydrogenase activity
C0073_006470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C0073_006480	COG3383	formate dehydrogenase (NAD+) activity
C0073_006485	COG0514	ATP-dependent DNA helicase (RecQ)
C0073_006515	COG1342	Belongs to the UPF0251 family
C0073_006530	COG1309	transcriptional regulator
C0073_006540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0073_006550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0073_006575	COG0367	asparagine synthase
C0073_006580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0073_006605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0073_006640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0073_006655	COG1091	dTDP-4-dehydrorhamnose reductase activity
C0073_006665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C0073_006675	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C0073_006695	COG0577	efflux transmembrane transporter activity
C0073_006695	COG1136	(ABC) transporter
C0073_006700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_006705	COG1227	inorganic diphosphatase activity
C0073_006715	COG0497	DNA recombination
C0073_006720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0073_006725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0073_006730	COG0443	Heat shock 70 kDa protein
C0073_006735	COG0484	heat shock protein binding
C0073_006765	COG1285	pathogenesis
C0073_006775	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0073_006795	COG2391	methyltransferase activity
C0073_006810	COG1566	PFAM secretion protein HlyD family protein
C0073_006815	COG1136	(ABC) transporter
C0073_006815	COG0577	efflux transmembrane transporter activity
C0073_006820	COG1136	(ABC) transporter
C0073_006820	COG0577	efflux transmembrane transporter activity
C0073_006825	COG0577	efflux transmembrane transporter activity
C0073_006825	COG1136	(ABC) transporter
C0073_006835	COG0095	Lipoate-protein ligase
C0073_006845	COG0702	epimerase
C0073_006850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0073_006855	COG1454	alcohol dehydrogenase
C0073_006865	COG0564	pseudouridine synthase activity
C0073_006870	COG1957	nucleoside hydrolase
C0073_006900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0073_006905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_006910	COG0745	RESPONSE REGULATOR receiver
C0073_006915	COG5000	phosphorelay sensor kinase activity
C0073_006915	COG5002	protein histidine kinase activity
C0073_006940	COG0741	lytic transglycosylase activity
C0073_006940	COG1388	LysM domain
C0073_006945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0073_006950	COG2226	methyltransferase
C0073_006955	COG0328	RNA-DNA hybrid ribonuclease activity
C0073_006960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0073_006970	COG3437	response regulator, receiver
C0073_006970	COG0784	Response regulator, receiver
C0073_006975	COG2375	cellular response to nickel ion
C0073_006980	COG4771	TonB-dependent receptor
C0073_006985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_006990	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_006995	COG1120	ATPase activity
C0073_007000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0073_007015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_007040	COG0708	Exodeoxyribonuclease III
C0073_007070	COG3132	Protein of unknown function, DUF480
C0073_007085	COG2841	Protein conserved in bacteria
C0073_007095	COG0534	Mate efflux family protein
C0073_007130	COG1309	transcriptional regulator
C0073_007165	COG3152	Membrane
C0073_007180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_007190	COG2207	Transcriptional regulator
C0073_007195	COG0538	isocitrate dehydrogenase activity
C0073_007205	COG3048	D-serine ammonia-lyase activity
C0073_007210	COG2610	gluconate transmembrane transporter activity
C0073_007215	COG0583	DNA-binding transcription factor activity
C0073_007225	COG0791	NLP P60 protein
C0073_007230	COG0583	DNA-binding transcription factor activity
C0073_007235	COG0450	alkyl hydroperoxide reductase
C0073_007255	COG0500	methyltransferase
C0073_007260	COG4106	trans-aconitate 2-methyltransferase activity
C0073_007265	COG1801	Protein of unknown function DUF72
C0073_007275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0073_007280	COG0217	transcriptional regulatory protein
C0073_007285	COG1126	abc transporter atp-binding protein
C0073_007290	COG0765	amino acid transport
C0073_007295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_007305	COG2203	Gaf domain
C0073_007305	COG2199	diguanylate cyclase activity
C0073_007310	COG2271	Major facilitator Superfamily
C0073_007320	COG2197	response regulator
C0073_007325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0073_007345	COG1785	Belongs to the alkaline phosphatase family
C0073_007350	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0073_007355	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0073_007365	COG1199	ATP-dependent helicase activity
C0073_007410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0073_007415	COG4660	Part of a membrane complex involved in electron transport
C0073_007420	COG4659	FMN binding
C0073_007425	COG4658	electron transport chain
C0073_007440	COG4657	Part of a membrane complex involved in electron transport
C0073_007460	COG0346	lactoylglutathione lyase activity
C0073_007475	COG1187	pseudouridine synthase activity
C0073_007480	COG2807	transmembrane transport
C0073_007490	COG0583	DNA-binding transcription factor activity
C0073_007500	COG1607	acyl-coa hydrolase
C0073_007505	COG2979	Protein of unknown function (DUF533)
C0073_007515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0073_007525	COG1294	oxidase, subunit
C0073_007545	COG3220	belongs to the UPF0276 family
C0073_007560	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0073_007565	COG2814	Major facilitator Superfamily
C0073_007575	COG0656	L-ascorbic acid biosynthetic process
C0073_007620	COG0583	DNA-binding transcription factor activity
C0073_007630	COG0840	transmembrane signaling receptor activity
C0073_007635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0073_007640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0073_007645	COG2271	Major facilitator Superfamily
C0073_007650	COG1349	DNA-binding transcription factor activity
C0073_007660	COG0584	glycerophosphoryl diester phosphodiesterase
C0073_007665	COG4574	serine-type endopeptidase inhibitor activity
C0073_007670	COG3085	chromosome segregation
C0073_007675	COG0583	DNA-binding transcription factor activity
C0073_007690	COG1448	Aminotransferase
C0073_007705	COG0658	competence protein
C0073_007705	COG2333	competence protein COMEC
C0073_007715	COG1663	tetraacyldisaccharide 4'-kinase activity
C0073_007720	COG2835	tetraacyldisaccharide 4'-kinase activity
C0073_007725	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C0073_007730	COG2197	response regulator
C0073_007735	COG0322	excinuclease ABC activity
C0073_007765	COG3039	Transposase
C0073_007790	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0073_007800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0073_007865	COG2119	membrane
C0073_007870	COG0023	Translation Initiation Factor
C0073_007895	COG0513	Belongs to the DEAD box helicase family
C0073_007905	COG0493	'glutamate synthase
C0073_007910	COG0067	glutamate synthase
C0073_007910	COG0069	glutamate synthase activity
C0073_007910	COG0070	glutamate synthase
C0073_007955	COG3436	PFAM IS66 Orf2 family protein
C0073_007960	COG4372	Transposase
C0073_007990	COG3634	alkyl hydroperoxide reductase activity
C0073_008000	COG0517	IMP dehydrogenase activity
C0073_008005	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0073_008010	COG0343	queuine tRNA-ribosyltransferase activity
C0073_008015	COG1862	Preprotein translocase
C0073_008020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0073_008025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0073_008030	COG2897	thiosulfate sulfurtransferase activity
C0073_008040	COG0826	peptidase U32
C0073_008045	COG0826	peptidase U32
C0073_008050	COG3154	lipid carrier protein
C0073_008070	COG1104	cysteine desulfurase activity
C0073_008075	COG0822	iron-sulfur transferase activity
C0073_008085	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0073_008090	COG0443	Heat shock 70 kDa protein
C0073_008095	COG0633	Ferredoxin
C0073_008110	COG0105	UTP biosynthetic process
C0073_008115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0073_008130	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0073_008135	COG0124	histidyl-tRNA synthetase
C0073_008140	COG2976	Protein conserved in bacteria
C0073_008145	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0073_008150	COG1160	GTP binding
C0073_008155	COG1645	bacterial-type flagellum-dependent swarming motility
C0073_008165	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C0073_008170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0073_008170	COG0047	phosphoribosylformylglycinamidine synthase activity
C0073_008175	COG2199	diguanylate cyclase activity
C0073_008175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0073_008190	COG1007	ATP synthesis coupled electron transport
C0073_008195	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_008205	COG0713	ATP synthesis coupled electron transport
C0073_008210	COG0839	Belongs to the complex I subunit 6 family
C0073_008215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_008220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
C0073_008225	COG1034	ATP synthesis coupled electron transport
C0073_008245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_008250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_008265	COG0367	asparagine synthase
C0073_008275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C0073_008275	COG4651	solute:proton antiporter activity
C0073_008280	COG0647	UMP catabolic process
C0073_008285	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0073_008295	COG1902	pentaerythritol trinitrate reductase activity
C0073_008300	COG1253	flavin adenine dinucleotide binding
C0073_008315	COG0247	lactate metabolic process
C0073_008315	COG0277	FAD linked oxidase domain protein
C0073_008325	COG2050	protein possibly involved in aromatic compounds catabolism
C0073_008335	COG2056	Na+-H+ antiporter family
C0073_008340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0073_008345	COG0671	phosphoesterase, PA-phosphatase related
C0073_008350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0073_008355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0073_008365	COG0101	tRNA pseudouridine synthase activity
C0073_008370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0073_008375	COG0285	dihydrofolate synthase activity
C0073_008380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C0073_008385	COG0393	Putative heavy-metal-binding
C0073_008430	COG4667	esterase of the alpha-beta hydrolase superfamily
C0073_008435	COG1619	proteins homologs of microcin C7 resistance protein MccF
C0073_008440	COG1368	sulfuric ester hydrolase activity
C0073_008450	COG0527	aspartate kinase activity
C0073_008455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0073_008455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0073_008460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0073_008480	COG0596	Alpha beta hydrolase
C0073_008495	COG0577	efflux transmembrane transporter activity
C0073_008500	COG1136	(ABC) transporter
C0073_008515	COG2814	Major facilitator Superfamily
C0073_008540	COG0672	)-iron permease
C0073_008555	COG3039	Transposase
C0073_008570	COG0471	metal ion transport
C0073_008575	COG3118	belongs to the thioredoxin family
C0073_008585	COG1132	(ABC) transporter
C0073_008590	COG1132	(ABC) transporter
C0073_008600	COG2501	S4 domain
C0073_008615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0073_008660	COG2009	succinate dehydrogenase
C0073_008665	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C0073_008670	COG1053	succinate dehydrogenase
C0073_008685	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0073_008690	COG0045	succinate-CoA ligase (ADP-forming) activity
C0073_008730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0073_008740	COG3842	ATPase activity
C0073_008745	COG1840	ABC-type Fe3 transport system, periplasmic component
C0073_008755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0073_008765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0073_008780	COG3088	subunit of a heme lyase
C0073_008780	COG4235	cytochrome complex assembly
C0073_008790	COG1138	Cytochrome C-type biogenesis protein
C0073_008795	COG3301	Polysulphide reductase, NrfD
C0073_008800	COG0437	4 iron, 4 sulfur cluster binding
C0073_008805	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C0073_008820	COG0247	lactate metabolic process
C0073_008825	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
C0073_008830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C0073_008835	COG3012	SEC-C Motif Domain Protein
C0073_008840	COG0840	transmembrane signaling receptor activity
C0073_008845	COG1846	Transcriptional regulator
C0073_008845	COG1940	carbohydrate kinase activity
C0073_008850	COG3148	PFAM DTW domain containing protein
C0073_008855	COG0730	response to heat
C0073_008860	COG0583	DNA-binding transcription factor activity
C0073_008875	COG3593	DNA synthesis involved in DNA repair
C0073_008900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0073_008905	COG1011	Hydrolase
C0073_008920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C0073_008925	COG2832	Protein of unknown function (DUF454)
C0073_008930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C0073_008940	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0073_008950	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C0073_008965	COG1560	Kdo2-lipid A biosynthetic process
C0073_008970	COG1560	Kdo2-lipid A biosynthetic process
C0073_008995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0073_009005	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0073_009010	COG1136	(ABC) transporter
C0073_009015	COG4591	ABC-type transport system involved in lipoprotein release permease component
C0073_009020	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C0073_009035	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0073_009040	COG0740	serine-type endopeptidase activity
C0073_009045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0073_009050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0073_009055	COG0776	regulation of translation
C0073_009060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0073_009065	COG0488	(ABC) transporter
C0073_009070	COG0582	viral genome integration into host DNA
C0073_009075	COG0582	viral genome integration into host DNA
C0073_009165	COG2801	Transposase and inactivated derivatives
C0073_009180	COG3069	C4-dicarboxylate transmembrane transporter activity
C0073_009195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C0073_009195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0073_009200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0073_009210	COG0569	domain protein
C0073_009210	COG2985	domain, Protein
C0073_009225	COG0556	nucleotide-excision repair
C0073_009235	COG0586	Pfam SNARE associated Golgi protein
C0073_009240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0073_009245	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0073_009260	COG4681	YaeQ
C0073_009275	COG3829	transcription factor binding
C0073_009315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0073_009320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C0073_009325	COG0697	spore germination
C0073_009330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C0073_009370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0073_009375	COG3099	Belongs to the UPF0263 family
C0073_009380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C0073_009385	COG2894	cell division
C0073_009390	COG0850	regulation of cytokinetic process
C0073_009395	COG3100	YcgL domain-containing protein
C0073_009400	COG1760	l-serine dehydratase
C0073_009410	COG1760	l-serine dehydratase
C0073_009415	COG3123	guanosine phosphorylase activity
C0073_009425	COG0205	6-phosphofructokinase activity
C0073_009435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C0073_009440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0073_009455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C0073_009460	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C0073_009465	COG3385	transposase activity
C0073_009480	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0073_009485	COG0617	tRNA 3'-terminal CCA addition
C0073_009485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0073_009485	COG0517	IMP dehydrogenase activity
C0073_009500	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0073_009515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C0073_009520	COG2067	long-chain fatty acid transport protein
C0073_009535	COG1595	DNA-templated transcription, initiation
C0073_009545	COG2304	oxidoreductase activity
C0073_009565	COG0714	Associated with various cellular activities
C0073_009570	COG0183	Belongs to the thiolase family
C0073_009575	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0073_009575	COG1024	Enoyl-CoA hydratase
C0073_009580	COG2719	SpoVR family
C0073_009585	COG2718	Belongs to the UPF0229 family
C0073_009590	COG2766	serine protein kinase
C0073_009595	COG0514	ATP-dependent DNA helicase (RecQ)
C0073_009600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C0073_009610	COG0814	amino acid
C0073_009630	COG2824	Alkylphosphonate utilization operon protein PhnA
C0073_009645	COG3791	Glutathione-dependent formaldehyde-activating
C0073_009650	COG0406	alpha-ribazole phosphatase activity
C0073_009655	COG3706	GGDEF domain
C0073_009660	COG2840	Smr protein MutS2
C0073_009665	COG2890	protein-(glutamine-N5) methyltransferase activity
C0073_009670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0073_009680	COG0513	Belongs to the DEAD box helicase family
C0073_009690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0073_009690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0073_009695	COG0489	protein tyrosine kinase activity
C0073_009700	COG0572	uridine kinase
C0073_009705	COG0717	Belongs to the dCTP deaminase family
C0073_009710	COG0306	phosphate transporter
C0073_009745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0073_009750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0073_009755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0073_009765	COG0549	Belongs to the carbamate kinase family
C0073_009780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_009785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0073_009790	COG0697	spore germination
C0073_009795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0073_009795	COG3608	succinylglutamate desuccinylase aspartoacylase
C0073_009800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0073_009805	COG2068	MobA-Related Protein
C0073_009810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0073_009810	COG0493	'glutamate synthase
C0073_009815	COG0402	S-adenosylhomocysteine deaminase activity
C0073_009820	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C0073_009825	COG2080	2 iron, 2 sulfur cluster binding
C0073_009825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C0073_009830	COG2233	PERMEase
C0073_009835	COG0402	S-adenosylhomocysteine deaminase activity
C0073_009840	COG2252	PERMEase
C0073_009850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C0073_009855	COG2080	2 iron, 2 sulfur cluster binding
C0073_009860	COG3134	Outer membrane lipoprotein
C0073_009870	COG0318	PFAM AMP-dependent synthetase and ligase
C0073_009875	COG2199	diguanylate cyclase activity
C0073_009890	COG0107	imidazoleglycerol-phosphate synthase activity
C0073_009895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0073_009900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0073_009905	COG0131	Imidazoleglycerol-phosphate dehydratase
C0073_009905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0073_009910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0073_009915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0073_009920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0073_009930	COG1199	ATP-dependent helicase activity
C0073_009935	COG1214	PFAM Peptidase M22, glycoprotease
C0073_009945	COG2267	carboxylic ester hydrolase activity
C0073_009950	COG0318	PFAM AMP-dependent synthetase and ligase
C0073_009960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0073_009965	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C0073_009970	COG0709	Synthesizes selenophosphate from selenide and ATP
C0073_009985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0073_009990	COG0840	transmembrane signaling receptor activity
C0073_009995	COG1254	Belongs to the acylphosphatase family
C0073_010020	COG1530	ribonuclease E activity
C0073_010035	COG0424	maF-like protein
C0073_010040	COG1399	metal-binding, possibly nucleic acid-binding protein
C0073_010045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0073_010050	COG0416	fatty acid biosynthetic process
C0073_010055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0073_010065	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_010070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0073_010075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C0073_010080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C0073_010085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0073_010090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0073_010095	COG0470	DNA polymerase III
C0073_010100	COG0084	hydrolase, TatD family'
C0073_010120	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
C0073_010120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0073_010125	COG3008	intermembrane lipid transfer
C0073_010130	COG2995	paraquat-inducible protein a
C0073_010140	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C0073_010145	COG0372	Belongs to the citrate synthase family
C0073_010190	COG4221	oxidoreductase activity
C0073_010195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C0073_010200	COG3141	response to X-ray
C0073_010260	COG1067	ATP-dependent peptidase activity
C0073_010265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0073_010275	COG0488	(ABC) transporter
C0073_010285	COG0116	Belongs to the methyltransferase superfamily
C0073_010285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C0073_010290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0073_010295	COG0254	rRNA binding
C0073_010310	COG0167	dihydroorotate dehydrogenase activity
C0073_010315	COG2902	Dehydrogenase
C0073_010325	COG0308	aminopeptidase N
C0073_010335	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
C0073_010340	COG1956	GAF domain-containing protein
C0073_010350	COG3278	Belongs to the heme-copper respiratory oxidase family
C0073_010365	COG2010	Cytochrome c
C0073_010375	COG2217	Heavy metal translocating P-type atpase
C0073_010390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0073_010395	COG0589	response to stress
C0073_010400	COG0037	tRNA processing
C0073_010425	COG1177	transmembrane transport
C0073_010455	COG1869	D-ribose catabolic process
C0073_010460	COG1129	ABC transporter
C0073_010465	COG1172	Belongs to the binding-protein-dependent transport system permease family
C0073_010470	COG1879	ABC-type sugar transport system periplasmic component
C0073_010475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0073_010480	COG1609	Transcriptional regulator
C0073_010485	COG2199	diguanylate cyclase activity
C0073_010510	COG0784	Response regulator, receiver
C0073_010510	COG2205	protein histidine kinase activity
C0073_010515	COG3385	transposase activity
C0073_010520	COG0776	regulation of translation
C0073_010525	COG0072	phenylalanine-tRNA ligase activity
C0073_010525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0073_010530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0073_010535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0073_010540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0073_010545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0073_010550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0073_010565	COG0366	Alpha amylase catalytic
C0073_010575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0073_010585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0073_010590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0073_010595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0073_010600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C0073_010605	COG3313	Fe-S protein
C0073_010610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_010610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_010610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C0073_010615	COG1105	Belongs to the carbohydrate kinase PfkB family
C0073_010620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_010620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_010625	COG1609	Transcriptional regulator
C0073_010630	COG0814	amino acid
C0073_010665	COG1160	GTP binding
C0073_010685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0073_010690	COG2925	Exonuclease
C0073_010700	COG3345	alpha-galactosidase
C0073_010705	COG1380	Effector of murein hydrolase LrgA
C0073_010710	COG1346	cytolysis
C0073_010715	COG0295	cytidine deaminase activity
C0073_010720	COG3033	Beta-eliminating lyase
C0073_010730	COG3046	protein related to deoxyribodipyrimidine photolyase
C0073_010735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0073_010740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C0073_010775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0073_010790	COG0454	-acetyltransferase
C0073_010795	COG3158	transport of potassium into the cell
C0073_010800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0073_010805	COG0651	ATP synthesis coupled electron transport
C0073_010810	COG0650	Formate hydrogenlyase subunit 4
C0073_010815	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C0073_010815	COG3261	NADH dehydrogenase
C0073_010820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C0073_010825	COG3260	NADH ubiquinone oxidoreductase 20
C0073_010835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0073_010850	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C0073_010855	COG0298	carbon dioxide binding
C0073_010865	COG0309	Hydrogenase expression formation protein (HypE)
C0073_010870	COG0375	protein maturation
C0073_010875	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0073_010885	COG0444	Belongs to the ABC transporter superfamily
C0073_010890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0073_010895	COG0601	transmembrane transport
C0073_010905	COG1773	rubredoxin
C0073_010910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C0073_010915	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C0073_010920	COG5557	Pfam Polysulphide reductase, NrfD
C0073_010925	COG0437	4 iron, 4 sulfur cluster binding
C0073_010930	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C0073_010940	COG2203	Gaf domain
C0073_010940	COG4251	negative regulation of phosphorylation
C0073_010940	COG5001	Diguanylate cyclase
C0073_010940	COG3706	GGDEF domain
C0073_010945	COG0438	transferase activity, transferring glycosyl groups
C0073_010950	COG0438	transferase activity, transferring glycosyl groups
C0073_010970	COG0438	transferase activity, transferring glycosyl groups
C0073_011015	COG0438	transferase activity, transferring glycosyl groups
C0073_011020	COG1215	transferase activity, transferring glycosyl groups
C0073_011025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0073_011065	COG0784	Response regulator, receiver
C0073_011065	COG2205	protein histidine kinase activity
C0073_011080	COG0730	response to heat
C0073_011090	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_011100	COG1024	Enoyl-CoA hydratase
C0073_011105	COG1024	Enoyl-CoA hydratase
C0073_011115	COG1960	acyl-CoA dehydrogenase activity
C0073_011125	COG1024	Enoyl-CoA hydratase
C0073_011155	COG1584	GPR1 FUN34 yaaH family protein
C0073_011170	COG1115	amino acid carrier protein
C0073_011175	COG1024	Enoyl-CoA hydratase
C0073_011190	COG3162	membrane
C0073_011195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0073_011235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0073_011280	COG2801	Transposase and inactivated derivatives
C0073_011310	COG0697	spore germination
C0073_011320	COG2062	phosphohistidine phosphatase, SixA
C0073_011325	COG1025	Belongs to the peptidase M16 family
C0073_011340	COG1451	nucleotide metabolic process
C0073_011415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0073_011415	COG0519	Catalyzes the synthesis of GMP from XMP
C0073_011420	COG0516	GMP reductase activity
C0073_011420	COG0517	IMP dehydrogenase activity
C0073_011425	COG3038	cytochrome b561
C0073_011430	COG1570	exodeoxyribonuclease VII activity
C0073_011435	COG2188	Transcriptional regulator
C0073_011440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_011440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_011440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C0073_011445	COG0383	alpha-mannosidase activity
C0073_011450	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0073_011460	COG0386	Belongs to the glutathione peroxidase family
C0073_011465	COG0513	Belongs to the DEAD box helicase family
C0073_011480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0073_011485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0073_011490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0073_011530	COG4771	TonB-dependent receptor
C0073_011550	COG0058	SHG alpha-glucan phosphorylase activity
C0073_011565	COG2983	Belongs to the UPF0260 family
C0073_011575	COG1882	Formate acetyltransferase
C0073_011580	COG2116	formate transmembrane transporter activity
C0073_011585	COG1944	ATP diphosphatase activity
C0073_011590	COG2723	6-phospho-beta-galactosidase activity
C0073_011595	COG0583	DNA-binding transcription factor activity
C0073_011605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C0073_011635	COG0583	DNA-binding transcription factor activity
C0073_011640	COG0583	DNA-binding transcription factor activity
C0073_011645	COG2910	NAD(P)H-binding
C0073_011675	COG0861	Integral membrane protein TerC family
C0073_011680	COG2885	chlorophyll binding
C0073_011685	COG2199	diguanylate cyclase activity
C0073_011700	COG2154	pterin-4-alpha-carbinolamine dehydratase
C0073_011710	COG1012	belongs to the aldehyde dehydrogenase family
C0073_011715	COG1177	transmembrane transport
C0073_011720	COG1176	ABC-type spermidine putrescine transport system, permease component I
C0073_011725	COG3842	ATPase activity
C0073_011735	COG0583	DNA-binding transcription factor activity
C0073_011740	COG3768	UPF0283 membrane protein
C0073_011745	COG3106	COG3106 Predicted ATPase
C0073_011760	COG1842	Phage shock protein A
C0073_011765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C0073_011775	COG4168	peptide transport system, permease
C0073_011785	COG4172	Belongs to the ABC transporter superfamily
C0073_011790	COG4172	Belongs to the ABC transporter superfamily
C0073_011795	COG0326	Molecular chaperone. Has ATPase activity
C0073_011800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0073_011810	COG0659	secondary active sulfate transmembrane transporter activity
C0073_011855	COG5001	Diguanylate cyclase
C0073_011855	COG3300	MHYT domain
C0073_011870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0073_011880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0073_011885	COG0563	adenylate kinase activity
C0073_011895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C0073_011900	COG1286	toxin biosynthetic process
C0073_011905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0073_011910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0073_011915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0073_011920	COG1674	ftsk spoiiie
C0073_011920	COG0531	amino acid
C0073_011930	COG0686	Belongs to the AlaDH PNT family
C0073_011935	COG0492	ferredoxin-NADP+ reductase activity
C0073_011940	COG3706	GGDEF domain
C0073_011945	COG3134	Outer membrane lipoprotein
C0073_011950	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0073_011955	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C0073_011960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0073_011965	COG0542	response to heat
C0073_011970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0073_011975	COG1278	Cold shock
C0073_011980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0073_012000	COG0745	RESPONSE REGULATOR receiver
C0073_012005	COG2205	protein histidine kinase activity
C0073_012015	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C0073_012015	COG0392	lysyltransferase activity
C0073_012040	COG1435	thymidine kinase activity
C0073_012045	COG1757	Na H antiporter
C0073_012050	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0073_012055	COG2096	Adenosyltransferase
C0073_012060	COG3530	Putative quorum-sensing-regulated virulence factor
C0073_012065	COG0602	queuosine metabolic process
C0073_012070	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0073_012090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C0073_012100	COG0776	regulation of translation
C0073_012105	COG0539	negative regulation of cytoplasmic translation
C0073_012110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C0073_012115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0073_012130	COG2814	Major facilitator Superfamily
C0073_012150	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C0073_012155	COG5001	Diguanylate cyclase
C0073_012155	COG3300	MHYT domain
C0073_012160	COG0583	DNA-binding transcription factor activity
C0073_012165	COG3437	response regulator, receiver
C0073_012190	COG4989	oxidoreductase activity
C0073_012195	COG0724	RNA recognition motif
C0073_012205	COG1126	abc transporter atp-binding protein
C0073_012210	COG0765	amino acid transport
C0073_012215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_012220	COG4597	amino acid ABC transporter
C0073_012225	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
C0073_012235	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C0073_012250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0073_012255	COG1360	Flagellar Motor Protein
C0073_012270	COG0625	glutathione transferase activity
C0073_012280	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C0073_012295	COG0564	pseudouridine synthase activity
C0073_012300	COG4160	amino acid transport
C0073_012310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_012320	COG2431	L-lysine efflux transmembrane transporter activity
C0073_012325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0073_012330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_012335	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
C0073_012345	COG1393	Belongs to the ArsC family
C0073_012355	COG4783	chaperone-mediated protein folding
C0073_012360	COG0425	Belongs to the sulfur carrier protein TusA family
C0073_012385	COG3842	ATPase activity
C0073_012390	COG3833	ABC-type maltose transport systems, permease component
C0073_012395	COG1175	transmembrane transport
C0073_012405	COG3081	Nucleoid-associated protein
C0073_012410	COG3082	Protein of unknown function (DUF1414)
C0073_012415	COG3083	sulfuric ester hydrolase activity
C0073_012420	COG1464	Belongs to the NlpA lipoprotein family
C0073_012435	COG0574	Belongs to the PEP-utilizing enzyme family
C0073_012435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0073_012440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0073_012465	COG0840	transmembrane signaling receptor activity
C0073_012470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0073_012470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C0073_012475	COG0509	glycine decarboxylation via glycine cleavage system
C0073_012480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C0073_012485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0073_012490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0073_012515	COG2814	Major facilitator Superfamily
C0073_012520	COG0625	glutathione transferase activity
C0073_012530	COG0483	inositol monophosphate 1-phosphatase activity
C0073_012535	COG0840	transmembrane signaling receptor activity
C0073_012545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0073_012560	COG1086	Polysaccharide biosynthesis protein
C0073_012565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0073_012575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C0073_012585	COG2801	Transposase and inactivated derivatives
C0073_012595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C0073_012610	COG2089	acid synthase
C0073_012665	COG0301	tRNA thio-modification
C0073_012665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0073_012680	COG4953	penicillin-binding protein 1C
C0073_012685	COG2373	Large extracellular alpha-helical protein
C0073_012695	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0073_012700	COG5001	Diguanylate cyclase
C0073_012700	COG3300	MHYT domain
C0073_012705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0073_012715	COG1252	NADH dehydrogenase
C0073_012720	COG3150	esterase
C0073_012725	COG2233	PERMEase
C0073_012750	COG1301	dicarboxylic acid transport
C0073_012765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0073_012780	COG0537	adenosine 5'-monophosphoramidase activity
C0073_012815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0073_012820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0073_012830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0073_012835	COG0287	Prephenate dehydrogenase
C0073_012835	COG1605	Chorismate mutase
C0073_012855	COG0531	amino acid
C0073_012870	COG1253	flavin adenine dinucleotide binding
C0073_012875	COG0704	Plays a role in the regulation of phosphate uptake
C0073_012880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0073_012885	COG0581	inorganic phosphate transmembrane transporter activity
C0073_012890	COG0573	inorganic phosphate transmembrane transporter activity
C0073_012895	COG0590	tRNA wobble adenosine to inosine editing
C0073_012905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0073_012925	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0073_012930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0073_012935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0073_012965	COG2716	regulation of RNA biosynthetic process
C0073_012970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C0073_012980	COG2239	Acts as a magnesium transporter
C0073_012985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0073_012995	COG1705	Flagellar rod assembly protein muramidase FlgJ
C0073_012995	COG3951	Flagellar rod assembly protein muramidase FlgJ
C0073_013000	COG1706	bacterial-type flagellum-dependent cell motility
C0073_013005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C0073_013015	COG4787	bacterial-type flagellum-dependent cell motility
C0073_013025	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0073_013035	COG1815	bacterial-type flagellum-dependent cell motility
C0073_013040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C0073_013045	COG0784	Response regulator, receiver
C0073_013045	COG0835	chemotaxis
C0073_013050	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C0073_013065	COG0622	Phosphoesterase
C0073_013070	COG4166	transmembrane transport
C0073_013095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0073_013100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C0073_013105	COG1882	Formate acetyltransferase
C0073_013115	COG4166	transmembrane transport
C0073_013140	COG1278	Cold shock
C0073_013165	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C0073_013165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C0073_013170	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_013175	COG3433	isochorismatase activity
C0073_013175	COG1535	isochorismatase
C0073_013180	COG1021	2,3-dihydroxybenzoate-AMP ligase
C0073_013185	COG1169	isochorismate synthase
C0073_013190	COG4771	TonB-dependent receptor
C0073_013195	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0073_013205	COG0741	lytic transglycosylase activity
C0073_013215	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0073_013235	COG2911	Protein conserved in bacteria
C0073_013240	COG0729	surface antigen
C0073_013250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0073_013260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C0073_013270	COG4134	Bacterial extracellular solute-binding protein
C0073_013280	COG4136	ATPase activity
C0073_013285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0073_013290	COG2951	lytic endotransglycosylase activity
C0073_013295	COG1846	Transcriptional regulator
C0073_013305	COG0033	Phosphoglucomutase
C0073_013310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C0073_013315	COG0596	Alpha beta hydrolase
C0073_013330	COG0716	FMN binding
C0073_013340	COG0735	belongs to the Fur family
C0073_013345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0073_013355	COG1263	PTS System
C0073_013355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0073_013355	COG2190	(PTS) system
C0073_013360	COG0363	glucosamine-6-phosphate deaminase activity
C0073_013365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C0073_013370	COG1846	Transcriptional regulator
C0073_013370	COG1940	carbohydrate kinase activity
C0073_013375	COG2194	sulfuric ester hydrolase activity
C0073_013385	COG3275	phosphorelay sensor kinase activity
C0073_013390	COG3279	Response regulator of the LytR AlgR family
C0073_013395	COG1966	Carbon starvation protein
C0073_013405	COG1566	PFAM secretion protein HlyD family protein
C0073_013410	COG1061	Type III restriction enzyme res subunit
C0073_013415	COG2027	D-alanyl-D-alanine carboxypeptidase
C0073_013420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C0073_013425	COG3021	interspecies interaction between organisms
C0073_013435	COG1607	acyl-coa hydrolase
C0073_013440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0073_013445	COG3039	Transposase
C0073_013455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0073_013455	COG1013	pyruvate-flavodoxin oxidoreductase activity
C0073_013455	COG0674	pyruvate-flavodoxin oxidoreductase activity
C0073_013455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C0073_013470	COG0633	Ferredoxin
C0073_013470	COG3217	Mosc domain protein beta barrel domain protein
C0073_013470	COG3217	Mosc domain protein beta barrel domain protein
C0073_013470	COG0633	Ferredoxin
C0073_013480	COG0501	Belongs to the peptidase M48B family
C0073_013485	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0073_013490	COG1073	alpha beta
C0073_013490	COG2226	methyltransferase
C0073_013495	COG0156	8-amino-7-oxononanoate synthase activity
C0073_013505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0073_013520	COG0017	Asparaginyl-tRNA synthetase
C0073_013530	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C0073_013545	COG3069	C4-dicarboxylate transmembrane transporter activity
C0073_013555	COG1393	Belongs to the ArsC family
C0073_013560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0073_013565	COG1876	peptidase activity
C0073_013575	COG3263	regulation of cellular component size
C0073_013600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0073_013605	COG0505	Belongs to the CarA family
C0073_013610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0073_013625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0073_013630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C0073_013635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0073_013640	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C0073_013645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0073_013655	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
C0073_013685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0073_013690	COG0861	Integral membrane protein TerC family
C0073_013705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0073_013710	COG0601	transmembrane transport
C0073_013720	COG2095	MarC family integral membrane protein
C0073_013725	COG1012	belongs to the aldehyde dehydrogenase family
C0073_013725	COG1454	alcohol dehydrogenase
C0073_013735	COG1280	lysine exporter protein (LysE YggA)
C0073_013790	COG0471	metal ion transport
C0073_013800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C0073_013805	COG0791	NLP P60 protein
C0073_013815	COG3118	belongs to the thioredoxin family
C0073_013825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C0073_013830	COG0788	formyltetrahydrofolate deformylase activity
C0073_013840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0073_013855	COG1196	nuclear chromosome segregation
C0073_013855	COG0739	heme binding
C0073_013855	COG0741	lytic transglycosylase activity
C0073_013860	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C0073_013870	COG0436	Aminotransferase
C0073_013875	COG1288	antiporter activity
C0073_013880	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C0073_013890	COG2964	Protein conserved in bacteria
C0073_013895	COG3681	Belongs to the UPF0597 family
C0073_013905	COG0814	amino acid
C0073_013925	COG1166	arginine decarboxylase activity
C0073_013935	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0073_013960	COG2353	YceI-like domain
C0073_013965	COG0583	DNA-binding transcription factor activity
C0073_013975	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C0073_013980	COG0840	transmembrane signaling receptor activity
C0073_013985	COG0302	gtp cyclohydrolase
C0073_013995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0073_014010	COG2267	carboxylic ester hydrolase activity
C0073_014015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C0073_014030	COG0314	molybdopterin synthase activity
C0073_014035	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C0073_014040	COG0315	cyclic pyranopterin monophosphate synthase activity
C0073_014045	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0073_014050	COG3005	denitrification pathway
C0073_014060	COG0348	domain, Protein
C0073_014065	COG0437	4 iron, 4 sulfur cluster binding
C0073_014070	COG0243	molybdopterin cofactor binding
C0073_014080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0073_014085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0073_014090	COG3850	Histidine kinase
C0073_014095	COG2197	response regulator
C0073_014125	COG0121	glutamine amidotransferase
C0073_014130	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0073_014135	COG1960	acyl-CoA dehydrogenase activity
C0073_014140	COG1473	amidohydrolase
C0073_014145	COG2914	Belongs to the UPF0125 (RnfH) family
C0073_014150	COG2867	negative regulation of translational initiation
C0073_014155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0073_014165	COG0582	viral genome integration into host DNA
C0073_014185	COG3311	Transcriptional regulator
C0073_014195	COG5377	YqaJ viral recombinase family
C0073_014245	COG2003	Belongs to the UPF0758 family
C0073_014255	COG1518	maintenance of DNA repeat elements
C0073_014300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0073_014315	COG2731	YhcH YjgK YiaL family protein
C0073_014320	COG0800	Aldolase
C0073_014325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0073_014330	COG1414	Transcriptional regulator
C0073_014340	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_014360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0073_014375	COG5433	transposase activity
C0073_014390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C0073_014395	COG0083	homoserine kinase activity
C0073_014410	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C0073_014415	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C0073_014420	COG1946	Acyl-CoA thioesterase
C0073_014430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0073_014440	COG0009	L-threonylcarbamoyladenylate synthase
C0073_014450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C0073_014455	COG0512	Glutamine amidotransferase of anthranilate synthase
C0073_014455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0073_014460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0073_014465	COG0134	indole-3-glycerol-phosphate synthase activity
C0073_014465	COG0135	phosphoribosylanthranilate isomerase activity
C0073_014475	COG0159	tryptophan synthase activity
C0073_014485	COG2801	Transposase and inactivated derivatives
C0073_014490	COG1988	membrane-bound metal-dependent
C0073_014510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0073_014520	COG0798	PFAM Bile acid sodium symporter
C0073_014550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C0073_014560	COG0745	RESPONSE REGULATOR receiver
C0073_014575	COG4988	ABC transporter
C0073_014580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0073_014600	COG1720	tRNA m6t6A37 methyltransferase activity
C0073_014605	COG3038	cytochrome b561
C0073_014625	COG2862	Uncharacterized protein family, UPF0114
C0073_014640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0073_014645	COG1396	sequence-specific DNA binding
C0073_014645	COG1917	Cupin 2, conserved barrel domain protein
C0073_014660	COG0531	amino acid
C0073_014670	COG0531	amino acid
C0073_014685	COG0405	Gamma-glutamyltransferase
C0073_014690	COG2974	May be involved in recombination
C0073_014700	COG0420	3'-5' exonuclease activity
C0073_014705	COG0419	ATPase involved in DNA repair
C0073_014710	COG3384	dioxygenase
C0073_014720	COG0469	pyruvate kinase activity
C0073_014725	COG3264	Mechanosensitive ion channel
C0073_014725	COG1196	nuclear chromosome segregation
C0073_014735	COG3590	peptidase
C0073_014740	COG3706	GGDEF domain
C0073_014745	COG2190	(PTS) system
C0073_014755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_014760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C0073_014765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0073_014780	COG2770	Histidine kinase
C0073_014780	COG3437	response regulator, receiver
C0073_014785	COG3267	Type II secretory pathway component ExeA
C0073_014785	COG3409	Peptidoglycan-binding domain 1 protein
C0073_014795	COG3031	protein transport across the cell outer membrane
C0073_014805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0073_014810	COG1459	type II secretion system
C0073_014815	COG2165	general secretion pathway protein
C0073_014825	COG2165	general secretion pathway protein
C0073_014830	COG4795	General secretion pathway protein
C0073_014835	COG3156	type II secretion system protein K
C0073_014845	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
C0073_014860	COG0670	Belongs to the BI1 family
C0073_014865	COG1289	transmembrane transporter activity
C0073_014870	COG2920	part of a sulfur-relay system
C0073_014875	COG0673	inositol 2-dehydrogenase activity
C0073_014880	COG0583	DNA-binding transcription factor activity
C0073_014915	COG1032	radical SAM domain protein
C0073_014925	COG1566	PFAM secretion protein HlyD family protein
C0073_014930	COG3706	GGDEF domain
C0073_014935	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0073_014940	COG0531	amino acid
C0073_014965	COG0281	malic enzyme
C0073_014975	COG0534	Mate efflux family protein
C0073_014990	COG2233	PERMEase
C0073_014995	COG0095	Lipoate-protein ligase
C0073_015000	COG1115	amino acid carrier protein
C0073_015005	COG0019	diaminopimelate decarboxylase activity
C0073_015015	COG0678	peroxiredoxin activity
C0073_015040	COG0545	Peptidyl-prolyl cis-trans isomerase
C0073_015045	COG3142	Participates in the control of copper homeostasis
C0073_015070	COG5002	protein histidine kinase activity
C0073_015075	COG0745	RESPONSE REGULATOR receiver
C0073_015080	COG0346	lactoylglutathione lyase activity
C0073_015085	COG3284	Transcriptional regulator
C0073_015100	COG0697	spore germination
C0073_015110	COG3290	protein histidine kinase activity
C0073_015125	COG5433	transposase activity
C0073_015130	COG1846	Transcriptional regulator
C0073_015135	COG1566	PFAM secretion protein HlyD family protein
C0073_015160	COG0602	queuosine metabolic process
C0073_015175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0073_015180	COG3115	cell septum assembly
C0073_015185	COG1196	nuclear chromosome segregation
C0073_015195	COG2860	membrane
C0073_015205	COG3108	Peptidase M15
C0073_015210	COG2989	Protein conserved in bacteria
C0073_015225	COG0463	Glycosyl transferase, family 2
C0073_015240	COG0366	Alpha amylase catalytic
C0073_015275	COG3706	GGDEF domain
C0073_015285	COG3590	peptidase
C0073_015295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C0073_015300	COG1982	Orn Lys Arg decarboxylase major
C0073_015305	COG0531	amino acid
C0073_015310	COG3710	Transcriptional regulator
C0073_015315	COG0531	amino acid
C0073_015335	COG0814	amino acid
C0073_015365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0073_015370	COG0739	heme binding
C0073_015375	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C0073_015390	COG0251	oxidation-reduction process
C0073_015395	COG2801	Transposase and inactivated derivatives
C0073_015400	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0073_015410	COG3091	SprT-like family
C0073_015420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0073_015425	COG0189	ligase activity
C0073_015430	COG1678	Uncharacterized ACR, COG1678
C0073_015435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0073_015440	COG3104	oligopeptide transport
C0073_015455	COG0714	Associated with various cellular activities
C0073_015470	COG1115	amino acid carrier protein
C0073_015475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0073_015485	COG0825	malonyl-CoA metabolic process
C0073_015495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0073_015500	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0073_015505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0073_015510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0073_015515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0073_015530	COG0750	zinc metalloprotease
C0073_015535	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0073_015540	COG0575	Belongs to the CDS family
C0073_015545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0073_015550	COG0233	cytoplasmic translational termination
C0073_015555	COG0528	UMP kinase activity
C0073_015560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0073_015565	COG0052	Belongs to the universal ribosomal protein uS2 family
C0073_015570	COG0024	Methionine aminopeptidase
C0073_015580	COG2171	N-acyltransferase activity
C0073_015590	COG1263	PTS System
C0073_015590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0073_015630	COG0564	pseudouridine synthase activity
C0073_015635	COG3098	single-species biofilm formation
C0073_015660	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
C0073_015670	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0073_015670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0073_015685	COG1611	Belongs to the LOG family
C0073_015690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0073_015695	COG0473	3-isopropylmalate dehydrogenase activity
C0073_015705	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C0073_015710	COG2363	Small membrane protein
C0073_015720	COG0583	DNA-binding transcription factor activity
C0073_015725	COG0840	transmembrane signaling receptor activity
C0073_015730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0073_015745	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C0073_015750	COG1666	GTP binding
C0073_015760	COG2211	Major facilitator Superfamily
C0073_015765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0073_015775	COG2813	Specifically methylates the guanine in position
C0073_015780	COG0271	Belongs to the BolA IbaG family
C0073_015785	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0073_015790	COG1805	sodium ion transport
C0073_015795	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0073_015800	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0073_015805	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0073_015810	COG2871	sodium ion transport
C0073_015815	COG1477	protein flavinylation
C0073_015845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0073_015860	COG0300	oxidoreductase activity
C0073_015870	COG0415	Belongs to the DNA photolyase family
C0073_015875	COG0789	Transcriptional regulator
C0073_015880	COG3272	Protein of unknown function (DUF1722)
C0073_015910	COG1605	Chorismate mutase
C0073_015910	COG0077	Prephenate dehydratase
C0073_015950	COG4372	Transposase
C0073_015955	COG4804	nuclease activity
C0073_015975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0073_016050	COG5433	transposase activity
C0073_016100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0073_016105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0073_016145	COG2916	Histone family protein nucleoid-structuring protein H-NS
C0073_016150	COG2020	methyltransferase activity
C0073_016170	COG4584	PFAM Integrase catalytic
C0073_016230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C0073_016270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0073_016275	COG0826	peptidase U32
C0073_016280	COG1280	lysine exporter protein (LysE YggA)
C0073_016290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0073_016300	COG0745	RESPONSE REGULATOR receiver
C0073_016310	COG0643	Histidine kinase
C0073_016310	COG2198	Histidine kinase
C0073_016320	COG0835	chemotaxis
C0073_016325	COG0840	transmembrane signaling receptor activity
C0073_016335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C0073_016340	COG2201	protein-glutamate methylesterase activity
C0073_016365	COG2814	Major facilitator Superfamily
C0073_016380	COG2801	Transposase and inactivated derivatives
C0073_016385	COG4771	TonB-dependent receptor
C0073_016405	COG0748	coenzyme F420 binding
C0073_016410	COG3721	Heme iron utilization protein
C0073_016420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_016445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0073_016465	COG0737	Belongs to the 5'-nucleotidase family
C0073_016485	COG2204	response regulator
C0073_016490	COG0545	Peptidyl-prolyl cis-trans isomerase
C0073_016500	COG2900	Belongs to the SlyX family
C0073_016505	COG1047	Peptidyl-prolyl cis-trans
C0073_016510	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C0073_016520	COG0835	chemotaxis
C0073_016520	COG0784	Response regulator, receiver
C0073_016525	COG0429	hydrolase of the alpha beta-hydrolase fold
C0073_016530	COG5001	Diguanylate cyclase
C0073_016530	COG4251	negative regulation of phosphorylation
C0073_016530	COG2203	Gaf domain
C0073_016530	COG3706	GGDEF domain
C0073_016535	COG3089	Belongs to the UPF0270 family
C0073_016540	COG3954	Phosphoribulokinase
C0073_016555	COG1765	OsmC-like protein
C0073_016595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0073_016600	COG2313	pseudouridylate synthase activity
C0073_016625	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C0073_016655	COG0569	domain protein
C0073_016655	COG2985	domain, Protein
C0073_016660	COG1272	protein, Hemolysin III
C0073_016665	COG0076	glutamate decarboxylase activity
C0073_016670	COG2917	probably involved in intracellular septation
C0073_016675	COG2350	Protein conserved in bacteria
C0073_016685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0073_016690	COG1381	Involved in DNA repair and RecF pathway recombination
C0073_016705	COG0681	Belongs to the peptidase S26 family
C0073_016710	COG0481	GTPase activity
C0073_016720	COG3026	antisigma factor binding
C0073_016725	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C0073_016730	COG1595	DNA-templated transcription, initiation
C0073_016735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0073_016745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C0073_016750	COG0354	folic acid binding
C0073_016775	COG4232	protein-disulfide reductase activity
C0073_016795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0073_016800	COG0191	fructose-bisphosphate aldolase activity
C0073_016805	COG0126	phosphoglycerate kinase activity
C0073_016810	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0073_016815	COG1940	carbohydrate kinase activity
C0073_016820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0073_016825	COG2816	NAD+ diphosphatase activity
C0073_016835	COG4991	sh3 domain protein
C0073_016840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0073_016850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0073_016855	COG0840	transmembrane signaling receptor activity
C0073_016865	COG1278	Cold shock
C0073_016905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0073_016910	COG1162	GTPase activity
C0073_016915	COG0688	phosphatidylethanolamine metabolic process
C0073_016920	COG4628	conserved protein (DUF2132)
C0073_016935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0073_016950	COG1073	alpha beta
C0073_016955	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C0073_016965	COG2195	Cleaves the N-terminal amino acid of tripeptides
C0073_016970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0073_016975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C0073_016980	COG3178	'Phosphotransferase
C0073_016985	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C0073_016990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0073_016995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0073_017000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0073_017005	COG2967	ApaG domain
C0073_017010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0073_017025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0073_017035	COG3314	Sporulation integral membrane protein YlbJ
C0073_017040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0073_017045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0073_017050	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0073_017055	COG0142	geranyltranstransferase activity
C0073_017060	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C0073_017065	COG0330	HflC and HflK could
C0073_017070	COG0330	HflC and HflK could
C0073_017075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0073_017080	COG1923	regulation of RNA biosynthetic process
C0073_017085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0073_017090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0073_017095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0073_017105	COG0802	atpase or kinase
C0073_017110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0073_017110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0073_017135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C0073_017140	COG2011	ABC-type metal ion transport system permease component
C0073_017145	COG1464	Belongs to the NlpA lipoprotein family
C0073_017180	COG5002	protein histidine kinase activity
C0073_017180	COG2198	Histidine kinase
C0073_017180	COG0784	Response regulator, receiver
C0073_017220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0073_017225	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C0073_017230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0073_017235	COG2716	regulation of RNA biosynthetic process
C0073_017240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0073_017245	COG3013	Belongs to the UPF0304 family
C0073_017255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C0073_017260	COG0857	belongs to the CobB CobQ family
C0073_017260	COG0280	phosphate acetyltransferase
C0073_017265	COG1555	photosystem II stabilization
C0073_017270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C0073_017275	COG3104	oligopeptide transport
C0073_017280	COG0745	RESPONSE REGULATOR receiver
C0073_017310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0073_017325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C0073_017360	COG0440	acetolactate synthase activity
C0073_017365	COG0028	Belongs to the TPP enzyme family
C0073_017385	COG3385	transposase activity
C0073_017395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0073_017400	COG0473	3-isopropylmalate dehydrogenase activity
C0073_017405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0073_017410	COG0066	3-isopropylmalate dehydratase activity
C0073_017425	COG4143	(ABC) transporter
C0073_017435	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
C0073_017440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0073_017495	COG0459	protein refolding
C0073_017500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0073_017510	COG0534	Mate efflux family protein
C0073_017515	COG3030	protein affecting phage T7 exclusion by the F plasmid
C0073_017520	COG1027	Aspartate ammonia-lyase
C0073_017525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C0073_017530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0073_017535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C0073_017540	COG1610	YqeY-like protein
C0073_017545	COG0358	DNA primase activity
C0073_017570	COG3039	Transposase
C0073_017575	COG0456	acetyltransferase
C0073_017605	COG0582	viral genome integration into host DNA
C0073_017620	COG0151	Belongs to the GarS family
C0073_017625	COG0138	bifunctional purine biosynthesis protein purh
C0073_017635	COG3036	rescue of stalled ribosome
C0073_017640	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0073_017645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0073_017655	COG0673	inositol 2-dehydrogenase activity
C0073_017665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0073_017670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0073_017685	COG0477	Major facilitator Superfamily
C0073_017700	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_017715	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C0073_017730	COG0456	acetyltransferase
C0073_017740	COG1022	Amp-dependent synthetase and ligase
C0073_017745	COG2918	glutathione biosynthetic process
C0073_017750	COG0612	Peptidase, M16
C0073_017755	COG1238	metal cluster binding
C0073_017760	COG1064	alcohol dehydrogenase
C0073_017790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0073_017795	COG0359	binds to the 23S rRNA
C0073_017800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0073_017805	COG0360	Binds together with S18 to 16S ribosomal RNA
C0073_017810	COG1914	H( )-stimulated, divalent metal cation uptake system
C0073_017815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0073_017825	COG0776	regulation of translation
C0073_017840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C0073_017855	COG0560	Phosphoserine phosphatase
C0073_017865	COG0813	purine-nucleoside phosphorylase activity
C0073_017870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C0073_017875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C0073_017880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C0073_017890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0073_017895	COG0084	hydrolase, TatD family'
C0073_017900	COG2165	general secretion pathway protein
C0073_017910	COG1854	S-ribosylhomocysteine lyase activity
C0073_017925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0073_017925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0073_017980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0073_017985	COG1047	Peptidyl-prolyl cis-trans
C0073_017990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0073_017995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0073_018005	COG0728	peptidoglycan biosynthetic process
C0073_018010	COG0268	Binds directly to 16S ribosomal RNA
C0073_018015	COG0640	Transcriptional regulator
C0073_018020	COG0583	DNA-binding transcription factor activity
C0073_018030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C0073_018035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0073_018040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0073_018050	COG1051	belongs to the nudix hydrolase family
C0073_018055	COG3066	DNA modification
C0073_018065	COG0335	large ribosomal subunit rRNA binding
C0073_018070	COG0336	Belongs to the RNA methyltransferase TrmD family
C0073_018075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0073_018080	COG0228	four-way junction DNA binding
C0073_018085	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0073_018090	COG4137	Cytochrome C assembly protein
C0073_018095	COG4536	flavin adenine dinucleotide binding
C0073_018105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0073_018105	COG1017	nitric oxide dioxygenase activity
C0073_018110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C0073_018115	COG0039	L-malate dehydrogenase activity
C0073_018120	COG4160	amino acid transport
C0073_018125	COG4215	(ABC) transporter
C0073_018130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_018135	COG1126	abc transporter atp-binding protein
C0073_018140	COG1438	arginine binding
C0073_018145	COG2837	iron assimilation
C0073_018150	COG3842	ATPase activity
C0073_018160	COG1840	ABC-type Fe3 transport system, periplasmic component
C0073_018165	COG0347	Belongs to the P(II) protein family
C0073_018185	COG3022	response to hydroperoxide
C0073_018200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C0073_018205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C0073_018210	COG0762	integral membrane protein
C0073_018215	COG1872	DUF167
C0073_018225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0073_018230	COG0583	DNA-binding transcription factor activity
C0073_018245	COG1929	Belongs to the glycerate kinase type-1 family
C0073_018250	COG2610	gluconate transmembrane transporter activity
C0073_018255	COG3835	regulator
C0073_018260	COG3112	Uncharacterised protein family (UPF0231)
C0073_018290	COG0513	Belongs to the DEAD box helicase family
C0073_018315	COG0204	Acyl-transferase
C0073_018335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0073_018340	COG0583	DNA-binding transcription factor activity
C0073_018375	COG3104	oligopeptide transport
C0073_018400	COG3150	esterase
C0073_018410	COG3151	Protein conserved in bacteria
C0073_018415	COG0494	nUDIX hydrolase
C0073_018420	COG1538	Outer membrane efflux protein
C0073_018425	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C0073_018425	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0073_018430	COG1560	Kdo2-lipid A biosynthetic process
C0073_018435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_018435	COG2213	PTS system mannitol-specific
C0073_018440	COG0246	Mannitol dehydrogenase
C0073_018445	COG3722	fumarate hydratase activity
C0073_018455	COG0484	heat shock protein binding
C0073_018475	COG1671	Belongs to the UPF0178 family
C0073_018485	COG1988	membrane-bound metal-dependent
C0073_018490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C0073_018495	COG0513	Belongs to the DEAD box helicase family
C0073_018515	COG1575	Belongs to the MenA family. Type 1 subfamily
C0073_018520	COG1169	isochorismate synthase
C0073_018525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C0073_018530	COG0596	Alpha beta hydrolase
C0073_018535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C0073_018545	COG0318	PFAM AMP-dependent synthetase and ligase
C0073_018550	COG3291	Pkd domain containing protein
C0073_018555	COG2949	membrane
C0073_018560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0073_018575	COG0835	chemotaxis
C0073_018575	COG0784	Response regulator, receiver
C0073_018585	COG1444	tRNA N-acetyltransferase activity
C0073_018605	COG1803	Methylglyoxal synthase
C0073_018610	COG1979	alcohol dehydrogenase
C0073_018620	COG1595	DNA-templated transcription, initiation
C0073_018625	COG3712	iron ion homeostasis
C0073_018630	COG4772	TonB-dependent receptor
C0073_018635	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C0073_018640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_018645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C0073_018650	COG1120	ATPase activity
C0073_018685	COG4221	oxidoreductase activity
C0073_018705	COG1285	pathogenesis
C0073_018710	COG3385	transposase activity
C0073_018730	COG1368	sulfuric ester hydrolase activity
C0073_018735	COG1522	sequence-specific DNA binding
C0073_018745	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C0073_018755	COG1058	Belongs to the CinA family
C0073_018755	COG1546	Belongs to the CinA family
C0073_018765	COG0561	phosphatase activity
C0073_018775	COG2926	Belongs to the UPF0265 family
C0073_018820	COG3655	Transcriptional regulator
C0073_018845	COG1484	DNA-dependent DNA replication
C0073_018850	COG4584	PFAM Integrase catalytic
C0073_018875	COG0840	transmembrane signaling receptor activity
C0073_018925	COG0789	Transcriptional regulator
C0073_018940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0073_018950	COG3039	Transposase
C0073_018955	COG3041	Addiction module toxin RelE StbE family
C0073_018960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0073_018965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C0073_018990	COG3385	transposase activity
C0073_019030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C0073_019035	COG0564	pseudouridine synthase activity
C0073_019045	COG0110	maltose O-acetyltransferase activity
C0073_019050	COG0366	Alpha amylase catalytic
C0073_019055	COG1263	PTS System
C0073_019055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C0073_019075	COG0252	asparaginase activity
C0073_019080	COG1253	flavin adenine dinucleotide binding
C0073_019085	COG0586	Pfam SNARE associated Golgi protein
C0073_019090	COG1686	Belongs to the peptidase S11 family
C0073_019125	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C0073_019130	COG0527	aspartate kinase activity
C0073_019135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0073_019145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0073_019150	COG1546	Belongs to the CinA family
C0073_019160	COG5377	YqaJ viral recombinase family
C0073_019205	COG2003	Belongs to the UPF0758 family
C0073_019265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0073_019315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0073_019365	COG0582	viral genome integration into host DNA
C0073_019370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0073_019375	COG4667	esterase of the alpha-beta hydrolase superfamily
C0073_019385	COG1346	cytolysis
C0073_019390	COG1380	Effector of murein hydrolase LrgA
C0073_019395	COG0583	DNA-binding transcription factor activity
C0073_019405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C0073_019420	COG1943	Transposase
C0073_019425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0073_019430	COG2022	thiamine diphosphate biosynthetic process
C0073_019435	COG2022	thiamine diphosphate biosynthetic process
C0073_019435	COG2104	thiamine diphosphate biosynthetic process
C0073_019440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C0073_019445	COG0352	thiamine-phosphate diphosphorylase activity
C0073_019450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0073_019480	COG0745	RESPONSE REGULATOR receiver
C0073_019485	COG0642	Histidine kinase
C0073_019490	COG0189	ligase activity
C0073_019535	COG0477	Major facilitator Superfamily
C0073_019550	COG0312	modulator of DNA gyrase
C0073_019555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0073_019565	COG3164	Protein of unknown function
C0073_019570	COG1530	ribonuclease E activity
C0073_019575	COG0424	maF-like protein
C0073_019580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C0073_019585	COG1792	Involved in formation and maintenance of cell shape
C0073_019590	COG1077	Cell shape determining protein MreB Mrl
C0073_019615	COG2199	diguanylate cyclase activity
C0073_019615	COG2200	EAL domain
C0073_019620	COG2200	EAL domain
C0073_019625	COG0387	Pfam Sodium calcium exchanger
C0073_019635	COG2986	histidine ammonia-lyase
C0073_019640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C0073_019645	COG0010	Belongs to the arginase family
C0073_019650	COG1228	amidohydrolase
C0073_019655	COG2188	Transcriptional regulator
C0073_019660	COG0288	reversible hydration of carbon dioxide
C0073_019665	COG3385	transposase activity
C0073_019675	COG2177	Part of the ABC transporter FtsEX involved in
C0073_019680	COG2884	Cell division ATP-binding protein ftsE
C0073_019685	COG0552	protein localization to endoplasmic reticulum
C0073_019690	COG0742	ribosomal rna small subunit methyltransferase
C0073_019715	COG2249	NAD(P)H dehydrogenase (quinone) activity
C0073_019720	COG0583	DNA-binding transcription factor activity
C0073_019725	COG4221	oxidoreductase activity
C0073_019740	COG1770	oligopeptidase
C0073_019755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0073_019760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C0073_019770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0073_019780	COG2095	MarC family integral membrane protein
C0073_019795	COG1301	dicarboxylic acid transport
C0073_019820	COG3714	YhhN family
C0073_019870	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0073_019875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0073_019885	COG0049	tRNA binding
C0073_019890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0073_019895	COG2168	tRNA wobble position uridine thiolation
C0073_019905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C0073_019915	COG2964	Protein conserved in bacteria
C0073_019920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0073_019925	COG0085	RNA polymerase activity
C0073_019930	COG0222	ribosome binding
C0073_019935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0073_019940	COG0081	regulation of translation
C0073_019945	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0073_019950	COG0250	Participates in transcription elongation, termination and antitermination
C0073_019965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0073_019990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0073_019995	COG0569	domain protein
C0073_020000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0073_020030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C0073_020030	COG4191	Histidine kinase
C0073_020035	COG3005	denitrification pathway
C0073_020040	COG0243	molybdopterin cofactor binding
C0073_020090	COG2204	response regulator
C0073_020100	COG2205	protein histidine kinase activity
C0073_020115	COG1028	Short-chain dehydrogenase reductase Sdr
C0073_020120	COG0516	GMP reductase activity
C0073_020120	COG0517	IMP dehydrogenase activity
C0073_020125	COG5413	integral membrane protein
C0073_020135	COG1522	sequence-specific DNA binding
C0073_020140	COG2502	aspartate--ammonia ligase
C0073_020155	COG0564	pseudouridine synthase activity
C0073_020160	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0073_020165	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0073_020180	COG2964	Protein conserved in bacteria
C0073_020195	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0073_020200	COG1979	alcohol dehydrogenase
C0073_020210	COG3040	lipid binding
C0073_020250	COG0540	Belongs to the ATCase OTCase family
C0073_020255	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
C0073_020260	COG1438	arginine binding
C0073_020265	COG1288	antiporter activity
C0073_020270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0073_020295	COG3385	transposase activity
C0073_020300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0073_020310	COG3078	GTPase activator activity
C0073_020325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0073_020335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0073_020340	COG0408	coproporphyrinogen oxidase activity
C0073_020345	COG0009	L-threonylcarbamoyladenylate synthase
C0073_020355	COG0551	DNA topoisomerase type I activity
C0073_020360	COG2922	Belongs to the Smg family
C0073_020365	COG0758	DNA mediated transformation
C0073_020370	COG1652	LysM domain
C0073_020375	COG0242	peptide deformylase activity
C0073_020380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0073_020385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0073_020385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0073_020390	COG0569	domain protein
C0073_020395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0073_020400	COG1217	gtp-binding protein TYPA
C0073_020405	COG0174	glutamine synthetase
C0073_020420	COG2204	response regulator
C0073_020425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0073_020450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0073_020455	COG0583	DNA-binding transcription factor activity
C0073_020460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0073_020460	COG0519	Catalyzes the synthesis of GMP from XMP
C0073_020475	COG1396	sequence-specific DNA binding
C0073_020480	COG1012	belongs to the aldehyde dehydrogenase family
C0073_020490	COG2962	Rard protein
C0073_020500	COG2391	methyltransferase activity
C0073_020505	COG2885	chlorophyll binding
C0073_020505	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C0073_020525	COG3978	acetolactate synthase activity
C0073_020540	COG0606	chelatase, subunit chli
C0073_020545	COG0204	Acyl-transferase
C0073_020550	COG0204	Acyl-transferase
C0073_020555	COG1683	Conserved Protein
C0073_020565	COG1335	isochorismatase
C0073_020575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0073_020580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0073_020590	COG3084	Protein conserved in bacteria
C0073_020595	COG2203	Gaf domain
C0073_020595	COG3706	GGDEF domain
C0073_020595	COG4251	negative regulation of phosphorylation
C0073_020595	COG5001	Diguanylate cyclase
C0073_020610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0073_020615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0073_020620	COG1561	YicC-like family, N-terminal region
C0073_020625	COG0583	DNA-binding transcription factor activity
C0073_020640	COG0583	DNA-binding transcription factor activity
C0073_020680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C0073_020685	COG0385	Bile acid
C0073_020690	COG0531	amino acid
C0073_020695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0073_020700	COG0531	amino acid
C0073_020705	COG2731	YhcH YjgK YiaL family protein
C0073_020715	COG1609	Transcriptional regulator
C0073_020750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C0073_020755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0073_020755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0073_020770	COG3074	FtsZ-dependent cytokinesis
C0073_020780	COG1045	serine acetyltransferase
C0073_020790	COG0745	RESPONSE REGULATOR receiver
C0073_020795	COG2205	protein histidine kinase activity
C0073_020800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0073_020805	COG0534	Mate efflux family protein
C0073_020820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0073_020825	COG2937	Belongs to the GPAT DAPAT family
C0073_020830	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0073_020835	COG3161	chorismate lyase activity
C0073_020865	COG0604	alcohol dehydrogenase
C0073_020870	COG1609	Transcriptional regulator
C0073_020875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0073_020890	COG1519	Transferase
C0073_020895	COG0859	PFAM glycosyl transferase family 9
C0073_020900	COG0463	Glycosyl transferase, family 2
C0073_020905	COG0859	PFAM glycosyl transferase family 9
C0073_020910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0073_020915	COG2990	Protein conserved in bacteria
C0073_020920	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0073_020930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0073_020935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0073_020940	COG2003	Belongs to the UPF0758 family
C0073_020945	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0073_020950	COG0756	dUTP diphosphatase activity
C0073_020955	COG1309	transcriptional regulator
C0073_020960	COG0668	transmembrane transport
C0073_020965	COG0166	Belongs to the GPI family
C0073_020970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0073_020990	COG0045	succinate-CoA ligase (ADP-forming) activity
C0073_020990	COG1042	CoA-binding domain protein
C0073_020990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0073_021020	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C0073_021025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C0073_021030	COG1739	Uncharacterized protein family UPF0029
C0073_021035	COG0006	proline dipeptidase activity
C0073_021040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0073_021045	COG1024	Enoyl-CoA hydratase
C0073_021045	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0073_021050	COG0183	Belongs to the thiolase family
C0073_021075	COG0425	Belongs to the sulfur carrier protein TusA family
C0073_021080	COG0251	oxidation-reduction process
C0073_021085	COG2885	chlorophyll binding
C0073_021090	COG2818	Glycosylase
C0073_021095	COG0752	glycyl-tRNA synthetase alpha subunit
C0073_021100	COG0751	glycine-tRNA ligase activity
C0073_021110	COG2200	EAL domain
C0073_021110	COG2202	Pas domain
C0073_021110	COG2199	diguanylate cyclase activity
C0073_021125	COG1609	Transcriptional regulator
C0073_021155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0073_021165	COG2960	long-chain fatty acid transporting porin activity
C0073_021170	COG5001	Diguanylate cyclase
C0073_021180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C0073_021195	COG3118	belongs to the thioredoxin family
C0073_021200	COG0513	Belongs to the DEAD box helicase family
C0073_021205	COG0248	Ppx GppA phosphatase
C0073_021215	COG0742	ribosomal rna small subunit methyltransferase
C0073_021230	COG3469	chitinase activity
C0073_021235	COG3397	chitin binding
C0073_021245	COG0084	hydrolase, TatD family'
C0073_021250	COG0805	protein transport
C0073_021255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0073_021260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0073_021265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0073_021270	COG3165	ubiquinone biosynthetic process from chorismate
C0073_021275	COG2226	methyltransferase
C0073_021280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0073_021285	COG0402	S-adenosylhomocysteine deaminase activity
C0073_021290	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C0073_021330	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C0073_021335	COG0848	biopolymer transport protein
C0073_021340	COG0811	peptide transport
C0073_021345	COG0811	peptide transport
C0073_021355	COG2771	luxR family
C0073_021360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C0073_021365	COG1349	DNA-binding transcription factor activity
C0073_021370	COG0745	RESPONSE REGULATOR receiver
C0073_021375	COG2205	protein histidine kinase activity
C0073_021390	COG4452	Inner membrane protein CreD
C0073_021395	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0073_021400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0073_021405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0073_021410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0073_021415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0073_021420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0073_021425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0073_021435	COG0356	it plays a direct role in the translocation of protons across the membrane
C0073_021445	COG1475	DNA binding
C0073_021450	COG1192	Involved in chromosome partitioning
C0073_021455	COG0357	Ribosomal RNA small subunit methyltransferase G
C0073_021460	COG0445	tRNA wobble uridine modification
C0073_021465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C0073_021480	COG4615	Cyclic peptide transporter
C0073_021485	COG1120	ATPase activity
C0073_021490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0073_021500	COG3550	peptidyl-serine autophosphorylation
C0073_021535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0073_021545	COG3012	SEC-C Motif Domain Protein
C0073_021545	COG3318	Belongs to the UPF0149 family
C0073_021560	COG3645	SOS response
C0073_021585	COG4974	Belongs to the 'phage' integrase family
C0073_021590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0073_021595	COG0706	membrane insertase activity
C0073_021600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0073_021605	COG0594	ribonuclease P activity
C0073_021610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C0073_021615	COG1126	abc transporter atp-binding protein
C0073_021720	COG1525	nuclease
C0073_021750	COG0776	regulation of translation
C0073_022420	COG1525	nuclease
C0073_022450	COG0776	regulation of translation
C0073_022480	COG1674	ftsk spoiiie
C0073_022695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease