locus-tag	class	description
M001_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M001_000010	COG0592	DNA-directed DNA polymerase activity
M001_000020	COG0187	DNA topoisomerase II activity
M001_000030	COG2378	regulation of single-species biofilm formation
M001_000035	COG2207	Transcriptional regulator
M001_000040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M001_000045	COG0071	Belongs to the small heat shock protein (HSP20) family
M001_000050	COG0071	Belongs to the small heat shock protein (HSP20) family
M001_000055	COG3977	Valine--pyruvate aminotransferase
M001_000070	COG2814	Major facilitator Superfamily
M001_000075	COG0745	RESPONSE REGULATOR receiver
M001_000080	COG2205	protein histidine kinase activity
M001_000100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M001_000105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_000105	COG4191	Histidine kinase
M001_000110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_000115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_000120	COG1309	transcriptional regulator
M001_000150	COG0561	phosphatase activity
M001_000155	COG2267	carboxylic ester hydrolase activity
M001_000160	COG0110	maltose O-acetyltransferase activity
M001_000165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M001_000170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M001_000175	COG1758	RNA polymerase activity
M001_000180	COG0194	GDP metabolic process
M001_000185	COG0859	PFAM glycosyl transferase family 9
M001_000190	COG3642	lipopolysaccharide core region biosynthetic process
M001_000230	COG0589	response to stress
M001_000235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M001_000240	COG1528	Iron-storage protein
M001_000245	COG2081	HI0933 family
M001_000250	COG3275	phosphorelay sensor kinase activity
M001_000255	COG3279	Response regulator of the LytR AlgR family
M001_000260	COG2223	nitrite transmembrane transporter activity
M001_000265	COG2081	HI0933 family
M001_000285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_000295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_000300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M001_000305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M001_000320	COG0583	DNA-binding transcription factor activity
M001_000325	COG4206	TonB-dependent receptor
M001_000365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M001_000370	COG2166	iron-sulfur cluster assembly
M001_000375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M001_000380	COG0210	DNA helicase
M001_000390	COG3245	cytochrome
M001_000395	COG1063	alcohol dehydrogenase
M001_000410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M001_000425	COG3307	-O-antigen
M001_000430	COG3306	glycosyltransferase involved in LPS biosynthesis
M001_000465	COG1280	lysine exporter protein (LysE YggA)
M001_000500	COG0489	protein tyrosine kinase activity
M001_000510	COG0210	DNA helicase
M001_000535	COG0737	Belongs to the 5'-nucleotidase family
M001_000545	COG2239	Acts as a magnesium transporter
M001_000550	COG1648	precorrin-2 dehydrogenase activity
M001_000550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M001_000555	COG2116	formate transmembrane transporter activity
M001_000565	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M001_000570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M001_000575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M001_000585	COG0018	arginyl-trna synthetase
M001_000595	COG1595	DNA-templated transcription, initiation
M001_000605	COG1968	undecaprenyl-diphosphatase activity
M001_000610	COG2017	converts alpha-aldose to the beta-anomer
M001_000615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M001_000620	COG1085	galactose-1-phosphate uridylyltransferase
M001_000625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M001_000630	COG1609	Transcriptional regulator
M001_000635	COG3250	beta-galactosidase activity
M001_000645	COG1129	ABC transporter
M001_000650	COG4211	Belongs to the binding-protein-dependent transport system permease family
M001_000660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M001_000675	COG0366	Alpha amylase catalytic
M001_000690	COG0443	Heat shock 70 kDa protein
M001_000695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M001_000700	COG3045	CreA protein
M001_000720	COG0174	glutamine synthetase
M001_000740	COG3842	ATPase activity
M001_000745	COG1176	ABC-type spermidine putrescine transport system, permease component I
M001_000750	COG1177	transmembrane transport
M001_000755	COG2258	MOSC domain
M001_000770	COG2050	protein possibly involved in aromatic compounds catabolism
M001_000775	COG0514	ATP-dependent DNA helicase (RecQ)
M001_000785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M001_000795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M001_000800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M001_000815	COG0254	rRNA binding
M001_000820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M001_000830	COG0702	epimerase
M001_000835	COG0814	amino acid
M001_000840	COG0281	malic enzyme
M001_000845	COG1295	ribonuclease BN
M001_000850	COG1490	D-aminoacyl-tRNA deacylase activity
M001_000855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M001_000860	COG0456	acetyltransferase
M001_000870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M001_000875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M001_000880	COG2610	gluconate transmembrane transporter activity
M001_000885	COG3265	gluconokinase activity
M001_000890	COG0129	dihydroxy-acid dehydratase activity
M001_000895	COG0800	Aldolase
M001_000900	COG1609	Transcriptional regulator
M001_000910	COG4942	peptidase
M001_000915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M001_000920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M001_000925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M001_000930	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M001_000935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M001_000935	COG0316	Belongs to the HesB IscA family
M001_000940	COG1040	competence protein
M001_000945	COG0596	Alpha beta hydrolase
M001_000965	COG2183	response to ionizing radiation
M001_000970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M001_000975	COG0745	RESPONSE REGULATOR receiver
M001_000990	COG0051	transcription antitermination factor activity, RNA binding
M001_000995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M001_001000	COG0088	Forms part of the polypeptide exit tunnel
M001_001005	COG0089	rRNA binding
M001_001010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M001_001015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M001_001020	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M001_001025	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M001_001030	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M001_001035	COG0255	Belongs to the universal ribosomal protein uL29 family
M001_001040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M001_001045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M001_001050	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M001_001055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M001_001060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M001_001065	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M001_001070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M001_001075	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M001_001080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M001_001085	COG1841	ribosomal large subunit assembly
M001_001090	COG0200	Binds to the 23S rRNA
M001_001095	COG0201	protein transport
M001_001100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M001_001105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M001_001110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M001_001115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M001_001120	COG0202	RNA polymerase activity
M001_001125	COG0203	ribosomal protein L17
M001_001165	COG4771	TonB-dependent receptor
M001_001170	COG3706	GGDEF domain
M001_001180	COG0745	RESPONSE REGULATOR receiver
M001_001195	COG0583	DNA-binding transcription factor activity
M001_001205	COG1741	Belongs to the pirin family
M001_001210	COG2259	Doxx family
M001_001215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M001_001220	COG1074	ATP-dependent DNA helicase activity
M001_001225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M001_001240	COG3706	GGDEF domain
M001_001270	COG1175	transmembrane transport
M001_001280	COG3842	ATPase activity
M001_001310	COG2873	o-acetylhomoserine
M001_001320	COG4533	DNA binding
M001_001340	COG5380	lipid catabolic process
M001_001345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M001_001350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M001_001375	COG0753	catalase activity
M001_001400	COG0525	valine-tRNA ligase activity
M001_001410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M001_001415	COG0795	lipopolysaccharide-transporting ATPase activity
M001_001420	COG0795	lipopolysaccharide-transporting ATPase activity
M001_001475	COG1494	fructose-1,6-bisphosphatase
M001_001490	COG2959	enzyme of heme biosynthesis
M001_001500	COG0181	hydroxymethylbilane synthase activity
M001_001505	COG3072	Adenylate cyclase
M001_001510	COG0400	carboxylic ester hydrolase activity
M001_001515	COG1965	Belongs to the frataxin family
M001_001525	COG0019	diaminopimelate decarboxylase activity
M001_001530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M001_001545	COG1011	Hydrolase
M001_001565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M001_001570	COG3028	Belongs to the UPF0307 family
M001_001575	COG0312	modulator of DNA gyrase
M001_001580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M001_001585	COG5007	Belongs to the BolA IbaG family
M001_001595	COG2854	intermembrane phospholipid transfer
M001_001600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M001_001605	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M001_001610	COG1127	ABC transporter
M001_001615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M001_001615	COG0517	IMP dehydrogenase activity
M001_001620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M001_001625	COG3117	lipopolysaccharide transmembrane transporter activity
M001_001630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M001_001635	COG1137	ATPase activity
M001_001650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_001655	COG1660	Displays ATPase and GTPase activities
M001_001660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_001665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_001665	COG3711	transcriptional antiterminator
M001_001680	COG3964	amidohydrolase
M001_001710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M001_001715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M001_001725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M001_001730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M001_001735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M001_001740	COG0723	plastoquinol--plastocyanin reductase activity
M001_001745	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M001_001750	COG2857	Cytochrome c1
M001_001755	COG0625	glutathione transferase activity
M001_001760	COG2969	positive regulation of protein catabolic process
M001_001765	COG2823	Periplasmic or secreted lipoprotein
M001_001770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M001_001775	COG0792	nuclease activity
M001_001780	COG3107	peptidoglycan biosynthetic process
M001_001785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M001_001810	COG1987	bacterial-type flagellum assembly
M001_001835	COG1677	Flagellar hook-basal body complex protein FliE
M001_001845	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M001_001880	COG1815	bacterial-type flagellum-dependent cell motility
M001_001895	COG1749	Flagellar hook protein flgE
M001_001900	COG4787	bacterial-type flagellum-dependent cell motility
M001_001905	COG4786	Flagellar basal body rod
M001_001910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M001_001915	COG1706	bacterial-type flagellum-dependent cell motility
M001_001925	COG4786	Flagellar basal body rod
M001_001925	COG1256	bacterial-type flagellum assembly
M001_001930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_001950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_001955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_001960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M001_001985	COG1191	sigma factor activity
M001_001990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M001_002005	COG1388	LysM domain
M001_002005	COG0741	lytic transglycosylase activity
M001_002010	COG2001	Belongs to the MraZ family
M001_002015	COG0275	rRNA processing
M001_002020	COG3116	cell division
M001_002025	COG0768	penicillin binding
M001_002035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M001_002040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M001_002045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M001_002050	COG0772	Belongs to the SEDS family
M001_002055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M001_002060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M001_002070	COG0849	cell division
M001_002075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M001_002080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M001_002090	COG0653	protein targeting
M001_002095	COG0494	nUDIX hydrolase
M001_002100	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M001_002105	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M001_002115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M001_002120	COG1459	type II secretion system
M001_002125	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M001_002150	COG2186	Transcriptional regulator
M001_002155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M001_002160	COG0508	dehydrogenase complex catalyzes the overall conversion of
M001_002165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M001_002175	COG0840	transmembrane signaling receptor activity
M001_002180	COG1752	Esterase of the alpha-beta hydrolase superfamily
M001_002185	COG1049	propionate catabolic process, 2-methylcitrate cycle
M001_002190	COG2200	EAL domain
M001_002200	COG0523	cobalamin synthesis protein
M001_002205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_002220	COG0477	Major facilitator Superfamily
M001_002235	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M001_002240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M001_002290	COG0165	Argininosuccinate lyase
M001_002295	COG0137	argininosuccinate synthase activity
M001_002305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M001_002310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M001_002320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M001_002330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M001_002345	COG0583	DNA-binding transcription factor activity
M001_002350	COG1380	Effector of murein hydrolase LrgA
M001_002355	COG1346	cytolysis
M001_002365	COG4667	esterase of the alpha-beta hydrolase superfamily
M001_002370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M001_002375	COG1546	Belongs to the CinA family
M001_002380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M001_002390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M001_002395	COG0527	aspartate kinase activity
M001_002400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M001_002435	COG1686	Belongs to the peptidase S11 family
M001_002440	COG0586	Pfam SNARE associated Golgi protein
M001_002445	COG1253	flavin adenine dinucleotide binding
M001_002455	COG0252	asparaginase activity
M001_002475	COG1263	PTS System
M001_002475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_002480	COG0366	Alpha amylase catalytic
M001_002485	COG0110	maltose O-acetyltransferase activity
M001_002495	COG0564	pseudouridine synthase activity
M001_002500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M001_002530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M001_002530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M001_002545	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M001_002550	COG0038	chloride channel
M001_002560	COG0316	Belongs to the HesB IscA family
M001_002565	COG1757	Na H antiporter
M001_002605	COG0297	glycogen (starch) synthase activity
M001_002610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M001_002615	COG2813	Specifically methylates the guanine in position
M001_002620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M001_002630	COG1392	Phosphate transport regulator
M001_002635	COG0306	phosphate transporter
M001_002640	COG0460	homoserine dehydrogenase
M001_002640	COG0527	aspartate kinase activity
M001_002645	COG0626	cystathionine gamma-synthase activity
M001_002660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M001_002665	COG0814	amino acid
M001_002670	COG1218	3'(2'),5'-bisphosphate nucleotidase
M001_002675	COG0494	nUDIX hydrolase
M001_002680	COG1011	Hydrolase
M001_002695	COG0110	maltose O-acetyltransferase activity
M001_002700	COG3174	membrane
M001_002705	COG3397	chitin binding
M001_002710	COG0840	transmembrane signaling receptor activity
M001_002720	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M001_002725	COG1215	transferase activity, transferring glycosyl groups
M001_002730	COG4783	chaperone-mediated protein folding
M001_002745	COG0726	polysaccharide deacetylase
M001_002745	COG1649	PFAM Uncharacterised BCR, COG1649
M001_002750	COG1215	transferase activity, transferring glycosyl groups
M001_002785	COG1328	CTP reductase activity
M001_002790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M001_002805	COG1448	Aminotransferase
M001_002845	COG0513	Belongs to the DEAD box helicase family
M001_002875	COG3112	Uncharacterised protein family (UPF0231)
M001_002880	COG3835	regulator
M001_002885	COG2610	gluconate transmembrane transporter activity
M001_002890	COG1929	Belongs to the glycerate kinase type-1 family
M001_002905	COG0583	DNA-binding transcription factor activity
M001_002910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M001_002920	COG1872	DUF167
M001_002925	COG0762	integral membrane protein
M001_002930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M001_002935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M001_002950	COG3022	response to hydroperoxide
M001_002970	COG0347	Belongs to the P(II) protein family
M001_002975	COG1840	ABC-type Fe3 transport system, periplasmic component
M001_002985	COG3842	ATPase activity
M001_002990	COG2837	iron assimilation
M001_002995	COG1438	arginine binding
M001_003000	COG1126	abc transporter atp-binding protein
M001_003005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_003010	COG4215	(ABC) transporter
M001_003015	COG4160	amino acid transport
M001_003020	COG0039	L-malate dehydrogenase activity
M001_003025	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M001_003030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M001_003030	COG1017	nitric oxide dioxygenase activity
M001_003040	COG4536	flavin adenine dinucleotide binding
M001_003045	COG4137	Cytochrome C assembly protein
M001_003050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M001_003055	COG0228	four-way junction DNA binding
M001_003060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M001_003065	COG0336	Belongs to the RNA methyltransferase TrmD family
M001_003070	COG0335	large ribosomal subunit rRNA binding
M001_003080	COG3066	DNA modification
M001_003085	COG1051	belongs to the nudix hydrolase family
M001_003095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M001_003100	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M001_003105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M001_003115	COG0583	DNA-binding transcription factor activity
M001_003120	COG0640	Transcriptional regulator
M001_003125	COG0268	Binds directly to 16S ribosomal RNA
M001_003130	COG0728	peptidoglycan biosynthetic process
M001_003135	COG0196	riboflavin kinase activity
M001_003140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M001_003145	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M001_003150	COG1047	Peptidyl-prolyl cis-trans
M001_003155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M001_003195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M001_003195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M001_003210	COG1854	S-ribosylhomocysteine lyase activity
M001_003225	COG0084	hydrolase, TatD family'
M001_003230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M001_003240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M001_003245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M001_003250	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M001_003255	COG0813	purine-nucleoside phosphorylase activity
M001_003265	COG0560	Phosphoserine phosphatase
M001_003275	COG3385	transposase activity
M001_003285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M001_003300	COG0776	regulation of translation
M001_003310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M001_003315	COG1914	H( )-stimulated, divalent metal cation uptake system
M001_003320	COG0360	Binds together with S18 to 16S ribosomal RNA
M001_003325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M001_003330	COG0359	binds to the 23S rRNA
M001_003335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M001_003360	COG0604	alcohol dehydrogenase
M001_003360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M001_003360	COG3321	synthase
M001_003360	COG4221	oxidoreductase activity
M001_003365	COG1238	metal cluster binding
M001_003370	COG0612	Peptidase, M16
M001_003375	COG2918	glutathione biosynthetic process
M001_003380	COG1022	Amp-dependent synthetase and ligase
M001_003390	COG0456	acetyltransferase
M001_003405	COG2425	protein containing a von Willebrand factor type A (vWA) domain
M001_003415	COG1028	Short-chain dehydrogenase reductase Sdr
M001_003425	COG0456	acetyltransferase
M001_003435	COG0477	Major facilitator Superfamily
M001_003440	COG0583	DNA-binding transcription factor activity
M001_003450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M001_003455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M001_003465	COG0673	inositol 2-dehydrogenase activity
M001_003475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M001_003480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M001_003485	COG3036	rescue of stalled ribosome
M001_003495	COG0138	bifunctional purine biosynthesis protein purh
M001_003500	COG0151	Belongs to the GarS family
M001_003520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M001_003530	COG1610	YqeY-like protein
M001_003535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M001_003540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M001_003545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M001_003550	COG1027	Aspartate ammonia-lyase
M001_003555	COG3030	protein affecting phage T7 exclusion by the F plasmid
M001_003560	COG0534	Mate efflux family protein
M001_003565	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M001_003570	COG0459	protein refolding
M001_003620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M001_003625	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M001_003630	COG1178	ABC-type Fe3 transport system permease component
M001_003635	COG4143	(ABC) transporter
M001_003650	COG0066	3-isopropylmalate dehydratase activity
M001_003655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M001_003660	COG0473	3-isopropylmalate dehydrogenase activity
M001_003665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M001_003690	COG0028	Belongs to the TPP enzyme family
M001_003695	COG0440	acetolactate synthase activity
M001_003720	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M001_003735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_003765	COG0745	RESPONSE REGULATOR receiver
M001_003770	COG3104	oligopeptide transport
M001_003775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M001_003780	COG1555	photosystem II stabilization
M001_003785	COG0280	phosphate acetyltransferase
M001_003785	COG0857	belongs to the CobB CobQ family
M001_003790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M001_003800	COG3013	Belongs to the UPF0304 family
M001_003805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M001_003810	COG2716	regulation of RNA biosynthetic process
M001_003815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M001_003820	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M001_003825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M001_003860	COG5002	protein histidine kinase activity
M001_003860	COG2198	Histidine kinase
M001_003860	COG0784	Response regulator, receiver
M001_003875	COG0840	transmembrane signaling receptor activity
M001_003885	COG1464	Belongs to the NlpA lipoprotein family
M001_003890	COG2011	ABC-type metal ion transport system permease component
M001_003895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M001_003915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M001_003915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M001_003920	COG0802	atpase or kinase
M001_003930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M001_003935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M001_003940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M001_003945	COG1923	regulation of RNA biosynthetic process
M001_003950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M001_003955	COG0330	HflC and HflK could
M001_003960	COG0330	HflC and HflK could
M001_003965	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M001_003970	COG0142	geranyltranstransferase activity
M001_003975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M001_003980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M001_003985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M001_004000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M001_004015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M001_004020	COG2967	ApaG domain
M001_004025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M001_004030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M001_004035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M001_004040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M001_004045	COG3178	'Phosphotransferase
M001_004050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M001_004055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M001_004060	COG2195	Cleaves the N-terminal amino acid of tripeptides
M001_004065	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M001_004085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M001_004100	COG4628	conserved protein (DUF2132)
M001_004105	COG0688	phosphatidylethanolamine metabolic process
M001_004110	COG1162	GTPase activity
M001_004115	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M001_004155	COG1278	Cold shock
M001_004165	COG0840	transmembrane signaling receptor activity
M001_004170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M001_004175	COG2252	PERMEase
M001_004185	COG0488	(ABC) transporter
M001_004200	COG0741	lytic transglycosylase activity
M001_004210	COG3416	Protein conserved in bacteria
M001_004230	COG4608	Belongs to the ABC transporter superfamily
M001_004235	COG0444	Belongs to the ABC transporter superfamily
M001_004245	COG4239	(ABC) transporter, permease
M001_004250	COG4174	ABC transporter (Permease)
M001_004265	COG0811	peptide transport
M001_004270	COG0811	peptide transport
M001_004275	COG0848	biopolymer transport protein
M001_004295	COG0616	signal peptide processing
M001_004300	COG1902	pentaerythritol trinitrate reductase activity
M001_004300	COG0446	pyridine nucleotide-disulphide oxidoreductase
M001_004305	COG0778	Nitroreductase
M001_004315	COG2264	protein methyltransferase activity
M001_004325	COG0604	alcohol dehydrogenase
M001_004330	COG0583	DNA-binding transcription factor activity
M001_004335	COG1263	PTS System
M001_004335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_004335	COG2190	(PTS) system
M001_004340	COG4145	pantothenate transmembrane transporter activity
M001_004350	COG0439	Biotin carboxylase
M001_004355	COG0511	ligase activity, forming carbon-carbon bonds
M001_004360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M001_004365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M001_004385	COG3381	protein complex oligomerization
M001_004395	COG3005	denitrification pathway
M001_004400	COG0745	RESPONSE REGULATOR receiver
M001_004410	COG1879	ABC-type sugar transport system periplasmic component
M001_004415	COG2205	protein histidine kinase activity
M001_004415	COG2198	Histidine kinase
M001_004415	COG0784	Response regulator, receiver
M001_004425	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M001_004430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M001_004435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M001_004435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M001_004455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M001_004460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M001_004465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M001_004470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M001_004495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M001_004500	COG0142	geranyltranstransferase activity
M001_004505	COG1722	exodeoxyribonuclease VII activity
M001_004510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M001_004515	COG1360	Flagellar Motor Protein
M001_004530	COG1534	Rna-binding protein
M001_004535	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M001_004545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M001_004550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M001_004555	COG0149	triose-phosphate isomerase activity
M001_004560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M001_004575	COG0779	Required for maturation of 30S ribosomal subunits
M001_004580	COG0195	Participates in both transcription termination and antitermination
M001_004585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M001_004590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M001_004595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M001_004600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M001_004605	COG1185	polyribonucleotide nucleotidyltransferase activity
M001_004610	COG2201	protein-glutamate methylesterase activity
M001_004615	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M001_004625	COG0840	transmembrane signaling receptor activity
M001_004630	COG0835	chemotaxis
M001_004640	COG2198	Histidine kinase
M001_004640	COG0643	Histidine kinase
M001_004650	COG0745	RESPONSE REGULATOR receiver
M001_004670	COG1280	lysine exporter protein (LysE YggA)
M001_004675	COG0826	peptidase U32
M001_004720	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M001_004745	COG0300	oxidoreductase activity
M001_004755	COG0840	transmembrane signaling receptor activity
M001_004770	COG3501	Rhs element vgr protein
M001_004815	COG1605	Chorismate mutase
M001_004815	COG0077	Prephenate dehydratase
M001_004845	COG3272	Protein of unknown function (DUF1722)
M001_004850	COG0789	Transcriptional regulator
M001_004855	COG0415	Belongs to the DNA photolyase family
M001_004865	COG0300	oxidoreductase activity
M001_004880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M001_004910	COG1477	protein flavinylation
M001_004915	COG2871	sodium ion transport
M001_004920	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M001_004925	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M001_004930	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M001_004935	COG1805	sodium ion transport
M001_004940	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M001_004945	COG0271	Belongs to the BolA IbaG family
M001_004950	COG2813	Specifically methylates the guanine in position
M001_004960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M001_004965	COG2211	Major facilitator Superfamily
M001_004970	COG3248	Nucleoside-binding outer membrane protein
M001_004975	COG1666	GTP binding
M001_004980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M001_004995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M001_005000	COG0840	transmembrane signaling receptor activity
M001_005005	COG0583	DNA-binding transcription factor activity
M001_005015	COG2363	Small membrane protein
M001_005020	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
M001_005030	COG3385	transposase activity
M001_005035	COG0473	3-isopropylmalate dehydrogenase activity
M001_005040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M001_005045	COG1611	Belongs to the LOG family
M001_005050	COG3706	GGDEF domain
M001_005060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M001_005060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M001_005070	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M001_005095	COG3098	single-species biofilm formation
M001_005100	COG0564	pseudouridine synthase activity
M001_005110	COG4580	involved in the transport of maltose and maltodextrins
M001_005120	COG1263	PTS System
M001_005120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_005130	COG2171	N-acyltransferase activity
M001_005140	COG0024	Methionine aminopeptidase
M001_005145	COG0052	Belongs to the universal ribosomal protein uS2 family
M001_005150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M001_005155	COG0528	UMP kinase activity
M001_005160	COG0233	cytoplasmic translational termination
M001_005165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M001_005170	COG0575	Belongs to the CDS family
M001_005175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M001_005180	COG0750	zinc metalloprotease
M001_005195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M001_005200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M001_005205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M001_005210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M001_005215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M001_005225	COG0825	malonyl-CoA metabolic process
M001_005235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M001_005240	COG1115	amino acid carrier protein
M001_005255	COG0714	Associated with various cellular activities
M001_005270	COG3104	oligopeptide transport
M001_005275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M001_005280	COG1678	Uncharacterized ACR, COG1678
M001_005285	COG0189	ligase activity
M001_005290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M001_005300	COG3091	SprT-like family
M001_005310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M001_005320	COG0251	oxidation-reduction process
M001_005330	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M001_005335	COG0739	heme binding
M001_005340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M001_005370	COG0814	amino acid
M001_005390	COG0531	amino acid
M001_005400	COG0488	(ABC) transporter
M001_005405	COG3710	Transcriptional regulator
M001_005410	COG0531	amino acid
M001_005415	COG1982	Orn Lys Arg decarboxylase major
M001_005420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M001_005430	COG3590	peptidase
M001_005440	COG2199	diguanylate cyclase activity
M001_005440	COG2203	Gaf domain
M001_005475	COG0366	Alpha amylase catalytic
M001_005490	COG0463	Glycosyl transferase, family 2
M001_005505	COG2989	Protein conserved in bacteria
M001_005510	COG3108	Peptidase M15
M001_005520	COG2860	membrane
M001_005530	COG1196	nuclear chromosome segregation
M001_005535	COG3115	cell septum assembly
M001_005540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M001_005555	COG1328	CTP reductase activity
M001_005560	COG0602	queuosine metabolic process
M001_005590	COG1566	PFAM secretion protein HlyD family protein
M001_005595	COG1846	Transcriptional regulator
M001_005610	COG0281	malic enzyme
M001_005615	COG3290	protein histidine kinase activity
M001_005625	COG0697	spore germination
M001_005635	COG1012	belongs to the aldehyde dehydrogenase family
M001_005640	COG3284	Transcriptional regulator
M001_005645	COG0346	lactoylglutathione lyase activity
M001_005650	COG0745	RESPONSE REGULATOR receiver
M001_005655	COG5002	protein histidine kinase activity
M001_005680	COG3142	Participates in the control of copper homeostasis
M001_005685	COG0545	Peptidyl-prolyl cis-trans isomerase
M001_005710	COG0678	peroxiredoxin activity
M001_005720	COG0019	diaminopimelate decarboxylase activity
M001_005725	COG1115	amino acid carrier protein
M001_005735	COG0095	Lipoate-protein ligase
M001_005740	COG2233	PERMEase
M001_005745	COG3706	GGDEF domain
M001_005755	COG0534	Mate efflux family protein
M001_005765	COG0281	malic enzyme
M001_005790	COG0531	amino acid
M001_005795	COG1752	Esterase of the alpha-beta hydrolase superfamily
M001_005800	COG3706	GGDEF domain
M001_005805	COG1566	PFAM secretion protein HlyD family protein
M001_005815	COG1032	radical SAM domain protein
M001_005865	COG0673	inositol 2-dehydrogenase activity
M001_005870	COG2920	part of a sulfur-relay system
M001_005875	COG1289	transmembrane transporter activity
M001_005880	COG0670	Belongs to the BI1 family
M001_005895	COG3623	hexulose-6-phosphate isomerase
M001_005900	COG0561	phosphatase activity
M001_005925	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M001_005935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M001_005945	COG3156	type II secretion system protein K
M001_005950	COG4795	General secretion pathway protein
M001_005955	COG2165	general secretion pathway protein
M001_005965	COG2165	general secretion pathway protein
M001_005970	COG1459	type II secretion system
M001_005975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M001_005985	COG3031	protein transport across the cell outer membrane
M001_005995	COG3267	Type II secretory pathway component ExeA
M001_005995	COG3409	Peptidoglycan-binding domain 1 protein
M001_006000	COG3437	response regulator, receiver
M001_006000	COG2770	Histidine kinase
M001_006015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M001_006020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M001_006025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_006035	COG2190	(PTS) system
M001_006040	COG3385	transposase activity
M001_006045	COG3706	GGDEF domain
M001_006050	COG3590	peptidase
M001_006060	COG3264	Mechanosensitive ion channel
M001_006060	COG1196	nuclear chromosome segregation
M001_006065	COG0469	pyruvate kinase activity
M001_006075	COG3384	dioxygenase
M001_006080	COG0419	ATPase involved in DNA repair
M001_006085	COG0420	3'-5' exonuclease activity
M001_006095	COG2974	May be involved in recombination
M001_006100	COG0405	Gamma-glutamyltransferase
M001_006105	COG0545	Peptidyl-prolyl cis-trans isomerase
M001_006110	COG1283	sodium-dependent phosphate transmembrane transporter activity
M001_006115	COG0531	amino acid
M001_006125	COG0531	amino acid
M001_006135	COG1012	belongs to the aldehyde dehydrogenase family
M001_006140	COG1917	Cupin 2, conserved barrel domain protein
M001_006140	COG1396	sequence-specific DNA binding
M001_006145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_006160	COG2862	Uncharacterized protein family, UPF0114
M001_006170	COG0745	RESPONSE REGULATOR receiver
M001_006180	COG3038	cytochrome b561
M001_006185	COG1720	tRNA m6t6A37 methyltransferase activity
M001_006205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M001_006210	COG4988	ABC transporter
M001_006225	COG0745	RESPONSE REGULATOR receiver
M001_006235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M001_006265	COG0798	PFAM Bile acid sodium symporter
M001_006275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M001_006295	COG1988	membrane-bound metal-dependent
M001_006315	COG0159	tryptophan synthase activity
M001_006320	COG0133	tryptophan synthase activity
M001_006325	COG0134	indole-3-glycerol-phosphate synthase activity
M001_006325	COG0135	phosphoribosylanthranilate isomerase activity
M001_006330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M001_006335	COG0512	Glutamine amidotransferase of anthranilate synthase
M001_006335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M001_006340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M001_006350	COG0009	L-threonylcarbamoyladenylate synthase
M001_006360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M001_006370	COG1946	Acyl-CoA thioesterase
M001_006375	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
M001_006380	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M001_006390	COG0083	homoserine kinase activity
M001_006395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M001_006420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M001_006440	COG1342	Belongs to the UPF0251 family
M001_006455	COG1309	transcriptional regulator
M001_006460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_006465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_006475	COG1091	dTDP-4-dehydrorhamnose reductase activity
M001_006495	COG1459	type II secretion system
M001_006505	COG2165	general secretion pathway protein
M001_006540	COG1450	Type ii and iii secretion system protein
M001_006570	COG2755	lipolytic protein G-D-S-L family
M001_006570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M001_006585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M001_006600	COG0463	Glycosyl transferase, family 2
M001_006600	COG1216	Glycosyl transferase, family 2
M001_006615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M001_006635	COG0577	efflux transmembrane transporter activity
M001_006635	COG1136	(ABC) transporter
M001_006640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_006645	COG1227	inorganic diphosphatase activity
M001_006650	COG0497	DNA recombination
M001_006655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M001_006660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M001_006665	COG0443	Heat shock 70 kDa protein
M001_006670	COG0484	heat shock protein binding
M001_006700	COG1285	pathogenesis
M001_006710	COG0446	pyridine nucleotide-disulphide oxidoreductase
M001_006745	COG1566	PFAM secretion protein HlyD family protein
M001_006750	COG1136	(ABC) transporter
M001_006750	COG0577	efflux transmembrane transporter activity
M001_006755	COG0577	efflux transmembrane transporter activity
M001_006755	COG1136	(ABC) transporter
M001_006760	COG1136	(ABC) transporter
M001_006760	COG0577	efflux transmembrane transporter activity
M001_006770	COG0095	Lipoate-protein ligase
M001_006780	COG0702	epimerase
M001_006785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M001_006790	COG1454	alcohol dehydrogenase
M001_006800	COG0564	pseudouridine synthase activity
M001_006830	COG1280	lysine exporter protein (LysE YggA)
M001_006845	COG3263	regulation of cellular component size
M001_006855	COG1876	peptidase activity
M001_006860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M001_006865	COG1393	Belongs to the ArsC family
M001_006875	COG3069	C4-dicarboxylate transmembrane transporter activity
M001_006890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M001_006900	COG0017	Asparaginyl-tRNA synthetase
M001_006915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M001_006920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M001_006925	COG0156	8-amino-7-oxononanoate synthase activity
M001_006930	COG1073	alpha beta
M001_006930	COG2226	methyltransferase
M001_006935	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
M001_006940	COG0501	Belongs to the peptidase M48B family
M001_006950	COG0633	Ferredoxin
M001_006950	COG3217	Mosc domain protein beta barrel domain protein
M001_006950	COG0633	Ferredoxin
M001_006950	COG3217	Mosc domain protein beta barrel domain protein
M001_006965	COG1013	pyruvate-flavodoxin oxidoreductase activity
M001_006965	COG0674	pyruvate-flavodoxin oxidoreductase activity
M001_006965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M001_006965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M001_006980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M001_006985	COG1607	acyl-coa hydrolase
M001_006995	COG3021	interspecies interaction between organisms
M001_007000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M001_007005	COG2027	D-alanyl-D-alanine carboxypeptidase
M001_007010	COG1061	Type III restriction enzyme res subunit
M001_007015	COG1566	PFAM secretion protein HlyD family protein
M001_007025	COG1966	Carbon starvation protein
M001_007030	COG3279	Response regulator of the LytR AlgR family
M001_007035	COG3275	phosphorelay sensor kinase activity
M001_007040	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M001_007040	COG2199	diguanylate cyclase activity
M001_007045	COG2194	sulfuric ester hydrolase activity
M001_007050	COG1846	Transcriptional regulator
M001_007050	COG1940	carbohydrate kinase activity
M001_007055	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M001_007060	COG0363	glucosamine-6-phosphate deaminase activity
M001_007065	COG1263	PTS System
M001_007065	COG2190	(PTS) system
M001_007065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_007075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M001_007080	COG0735	belongs to the Fur family
M001_007090	COG0716	FMN binding
M001_007105	COG0596	Alpha beta hydrolase
M001_007110	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M001_007115	COG0033	Phosphoglucomutase
M001_007130	COG2951	lytic endotransglycosylase activity
M001_007135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M001_007140	COG4136	ATPase activity
M001_007145	COG4135	transport system, permease component
M001_007150	COG4134	Bacterial extracellular solute-binding protein
M001_007160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M001_007170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M001_007180	COG0729	surface antigen
M001_007185	COG2911	Protein conserved in bacteria
M001_007205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M001_007215	COG0741	lytic transglycosylase activity
M001_007225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M001_007230	COG4771	TonB-dependent receptor
M001_007235	COG1169	isochorismate synthase
M001_007240	COG1021	2,3-dihydroxybenzoate-AMP ligase
M001_007245	COG1535	isochorismatase
M001_007245	COG3433	isochorismatase activity
M001_007250	COG1028	Short-chain dehydrogenase reductase Sdr
M001_007255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M001_007255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M001_007280	COG1278	Cold shock
M001_007305	COG4166	transmembrane transport
M001_007310	COG1349	DNA-binding transcription factor activity
M001_007315	COG1882	Formate acetyltransferase
M001_007320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M001_007325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M001_007335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M001_007350	COG4166	transmembrane transport
M001_007355	COG0622	Phosphoesterase
M001_007370	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M001_007375	COG0784	Response regulator, receiver
M001_007375	COG0835	chemotaxis
M001_007380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M001_007385	COG1815	bacterial-type flagellum-dependent cell motility
M001_007395	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M001_007405	COG4787	bacterial-type flagellum-dependent cell motility
M001_007415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M001_007420	COG1706	bacterial-type flagellum-dependent cell motility
M001_007435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_007440	COG2239	Acts as a magnesium transporter
M001_007450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M001_007455	COG2716	regulation of RNA biosynthetic process
M001_007470	COG3852	Histidine kinase
M001_007480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M001_007485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M001_007490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M001_007495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M001_007515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M001_007530	COG0590	tRNA wobble adenosine to inosine editing
M001_007535	COG0573	inorganic phosphate transmembrane transporter activity
M001_007540	COG0581	inorganic phosphate transmembrane transporter activity
M001_007545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M001_007550	COG0704	Plays a role in the regulation of phosphate uptake
M001_007555	COG1253	flavin adenine dinucleotide binding
M001_007570	COG0531	amino acid
M001_007585	COG1126	abc transporter atp-binding protein
M001_007590	COG0765	amino acid transport
M001_007595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_007600	COG2199	diguanylate cyclase activity
M001_007600	COG2203	Gaf domain
M001_007605	COG2271	Major facilitator Superfamily
M001_007615	COG2197	response regulator
M001_007620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M001_007640	COG1785	Belongs to the alkaline phosphatase family
M001_007645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M001_007650	COG0123	including yeast histone deacetylase and acetoin utilization protein
M001_007660	COG1199	ATP-dependent helicase activity
M001_007670	COG1605	Chorismate mutase
M001_007670	COG0287	Prephenate dehydrogenase
M001_007675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M001_007685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M001_007690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M001_007725	COG0537	adenosine 5'-monophosphoramidase activity
M001_007740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M001_007755	COG1301	dicarboxylic acid transport
M001_007760	COG0840	transmembrane signaling receptor activity
M001_007775	COG2354	Protein conserved in bacteria
M001_007785	COG2233	PERMEase
M001_007790	COG3150	esterase
M001_007795	COG1252	NADH dehydrogenase
M001_007805	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M001_007815	COG0446	pyridine nucleotide-disulphide oxidoreductase
M001_007825	COG2373	Large extracellular alpha-helical protein
M001_007830	COG4953	penicillin-binding protein 1C
M001_007840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M001_007840	COG0301	tRNA thio-modification
M001_007845	COG3385	transposase activity
M001_007860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_007865	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M001_007905	COG2089	acid synthase
M001_007915	COG1083	cytidylyl-transferase
M001_007930	COG1028	Short-chain dehydrogenase reductase Sdr
M001_007935	COG0318	PFAM AMP-dependent synthetase and ligase
M001_007950	COG1215	transferase activity, transferring glycosyl groups
M001_007960	COG1216	Glycosyl transferase, family 2
M001_007975	COG1215	transferase activity, transferring glycosyl groups
M001_007975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M001_007985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M001_007990	COG0673	inositol 2-dehydrogenase activity
M001_007995	COG1028	Short-chain dehydrogenase reductase Sdr
M001_008005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M001_008010	COG1083	cytidylyl-transferase
M001_008025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M001_008030	COG1086	Polysaccharide biosynthesis protein
M001_008045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M001_008055	COG0840	transmembrane signaling receptor activity
M001_008060	COG0483	inositol monophosphate 1-phosphatase activity
M001_008070	COG0625	glutathione transferase activity
M001_008075	COG2814	Major facilitator Superfamily
M001_008080	COG0583	DNA-binding transcription factor activity
M001_008085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M001_008090	COG0243	molybdopterin cofactor binding
M001_008110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M001_008115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M001_008120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M001_008125	COG0509	glycine decarboxylation via glycine cleavage system
M001_008130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M001_008130	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M001_008135	COG0840	transmembrane signaling receptor activity
M001_008160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M001_008165	COG0574	Belongs to the PEP-utilizing enzyme family
M001_008165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M001_008170	COG3385	transposase activity
M001_008185	COG1464	Belongs to the NlpA lipoprotein family
M001_008190	COG3083	sulfuric ester hydrolase activity
M001_008195	COG3082	Protein of unknown function (DUF1414)
M001_008200	COG3081	Nucleoid-associated protein
M001_008210	COG1175	transmembrane transport
M001_008215	COG3833	ABC-type maltose transport systems, permease component
M001_008220	COG3842	ATPase activity
M001_008235	COG3385	transposase activity
M001_008255	COG4783	chaperone-mediated protein folding
M001_008265	COG1393	Belongs to the ArsC family
M001_008275	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
M001_008290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M001_008295	COG2431	L-lysine efflux transmembrane transporter activity
M001_008305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_008315	COG4160	amino acid transport
M001_008320	COG0564	pseudouridine synthase activity
M001_008335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M001_008345	COG0625	glutathione transferase activity
M001_008360	COG0367	asparagine synthase
M001_008370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M001_008370	COG4651	solute:proton antiporter activity
M001_008375	COG0647	UMP catabolic process
M001_008390	COG1902	pentaerythritol trinitrate reductase activity
M001_008395	COG1253	flavin adenine dinucleotide binding
M001_008405	COG0247	lactate metabolic process
M001_008405	COG0277	FAD linked oxidase domain protein
M001_008415	COG2050	protein possibly involved in aromatic compounds catabolism
M001_008430	COG3300	MHYT domain
M001_008430	COG5001	Diguanylate cyclase
M001_008435	COG2199	diguanylate cyclase activity
M001_008435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M001_008450	COG1007	ATP synthesis coupled electron transport
M001_008455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_008465	COG0713	ATP synthesis coupled electron transport
M001_008470	COG0839	Belongs to the complex I subunit 6 family
M001_008475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_008480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M001_008485	COG1034	ATP synthesis coupled electron transport
M001_008500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_008500	COG0649	NAD binding
M001_008505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_008510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_008530	COG1770	oligopeptidase
M001_008535	COG4771	TonB-dependent receptor
M001_008540	COG1360	Flagellar Motor Protein
M001_008545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M001_008560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M001_008570	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M001_008575	COG4597	amino acid ABC transporter
M001_008580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_008585	COG0765	amino acid transport
M001_008590	COG1126	abc transporter atp-binding protein
M001_008600	COG0724	RNA recognition motif
M001_008605	COG4989	oxidoreductase activity
M001_008630	COG3437	response regulator, receiver
M001_008635	COG0583	DNA-binding transcription factor activity
M001_008640	COG5001	Diguanylate cyclase
M001_008640	COG3300	MHYT domain
M001_008645	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M001_008650	COG0778	Nitroreductase
M001_008665	COG2814	Major facilitator Superfamily
M001_008680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M001_008685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M001_008690	COG0539	negative regulation of cytoplasmic translation
M001_008695	COG0776	regulation of translation
M001_008705	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M001_008725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M001_008730	COG0602	queuosine metabolic process
M001_008735	COG3530	Putative quorum-sensing-regulated virulence factor
M001_008740	COG2096	Adenosyltransferase
M001_008745	COG2916	Histone family protein nucleoid-structuring protein H-NS
M001_008750	COG1757	Na H antiporter
M001_008755	COG1435	thymidine kinase activity
M001_008780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M001_008785	COG0326	Molecular chaperone. Has ATPase activity
M001_008790	COG4172	Belongs to the ABC transporter superfamily
M001_008795	COG4172	Belongs to the ABC transporter superfamily
M001_008805	COG4168	peptide transport system, permease
M001_008815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M001_008820	COG1842	Phage shock protein A
M001_008835	COG3106	COG3106 Predicted ATPase
M001_008840	COG3768	UPF0283 membrane protein
M001_008850	COG2154	pterin-4-alpha-carbinolamine dehydratase
M001_008865	COG2199	diguanylate cyclase activity
M001_008870	COG2885	chlorophyll binding
M001_008875	COG0861	Integral membrane protein TerC family
M001_008905	COG2910	NAD(P)H-binding
M001_008910	COG0583	DNA-binding transcription factor activity
M001_008915	COG0583	DNA-binding transcription factor activity
M001_008920	COG2271	Major facilitator Superfamily
M001_008930	COG1335	isochorismatase
M001_008940	COG0583	DNA-binding transcription factor activity
M001_008945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M001_008955	COG0583	DNA-binding transcription factor activity
M001_008960	COG2723	6-phospho-beta-galactosidase activity
M001_008965	COG1944	ATP diphosphatase activity
M001_008970	COG2116	formate transmembrane transporter activity
M001_008975	COG1882	Formate acetyltransferase
M001_008980	COG2983	Belongs to the UPF0260 family
M001_008995	COG0058	SHG alpha-glucan phosphorylase activity
M001_009000	COG0471	metal ion transport
M001_009005	COG3118	belongs to the thioredoxin family
M001_009015	COG1132	(ABC) transporter
M001_009020	COG1132	(ABC) transporter
M001_009030	COG2501	S4 domain
M001_009045	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
M001_009050	COG3385	transposase activity
M001_009090	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M001_009095	COG1053	succinate dehydrogenase
M001_009105	COG0567	Dehydrogenase, E1 component
M001_009110	COG0508	dehydrogenase complex catalyzes the overall conversion of
M001_009115	COG0045	succinate-CoA ligase (ADP-forming) activity
M001_009130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_009140	COG3842	ATPase activity
M001_009145	COG1840	ABC-type Fe3 transport system, periplasmic component
M001_009155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M001_009165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M001_009180	COG4235	cytochrome complex assembly
M001_009180	COG3088	subunit of a heme lyase
M001_009190	COG1138	Cytochrome C-type biogenesis protein
M001_009195	COG3301	Polysulphide reductase, NrfD
M001_009200	COG0437	4 iron, 4 sulfur cluster binding
M001_009205	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M001_009220	COG0247	lactate metabolic process
M001_009225	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
M001_009230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M001_009235	COG3012	SEC-C Motif Domain Protein
M001_009240	COG0840	transmembrane signaling receptor activity
M001_009245	COG1940	carbohydrate kinase activity
M001_009245	COG1846	Transcriptional regulator
M001_009255	COG0730	response to heat
M001_009260	COG0583	DNA-binding transcription factor activity
M001_009265	COG0697	spore germination
M001_009275	COG3593	DNA synthesis involved in DNA repair
M001_009325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M001_009330	COG1011	Hydrolase
M001_009345	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M001_009350	COG2832	Protein of unknown function (DUF454)
M001_009355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M001_009365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M001_009370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M001_009375	COG0583	DNA-binding transcription factor activity
M001_009385	COG1560	Kdo2-lipid A biosynthetic process
M001_009395	COG1560	Kdo2-lipid A biosynthetic process
M001_009420	COG0417	DNA replication proofreading
M001_009435	COG1451	nucleotide metabolic process
M001_009450	COG3069	C4-dicarboxylate transmembrane transporter activity
M001_009465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M001_009465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_009470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M001_009480	COG2985	domain, Protein
M001_009480	COG0569	domain protein
M001_009495	COG0556	nucleotide-excision repair
M001_009505	COG0586	Pfam SNARE associated Golgi protein
M001_009510	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M001_009515	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M001_009530	COG4681	YaeQ
M001_009615	COG0307	riboflavin synthase, alpha
M001_009625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M001_009630	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
M001_009635	COG0697	spore germination
M001_009640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M001_009680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M001_009685	COG3099	Belongs to the UPF0263 family
M001_009690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M001_009695	COG2894	cell division
M001_009700	COG0850	regulation of cytokinetic process
M001_009705	COG3100	YcgL domain-containing protein
M001_009710	COG1760	l-serine dehydratase
M001_009715	COG1760	l-serine dehydratase
M001_009720	COG3123	guanosine phosphorylase activity
M001_009725	COG1301	dicarboxylic acid transport
M001_009730	COG0205	6-phosphofructokinase activity
M001_009740	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M001_009745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M001_009755	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M001_009760	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M001_009785	COG0242	peptide deformylase activity
M001_009815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M001_009820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M001_009825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M001_009835	COG0549	Belongs to the carbamate kinase family
M001_009850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M001_009860	COG0697	spore germination
M001_009870	COG3608	succinylglutamate desuccinylase aspartoacylase
M001_009870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M001_009875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M001_009880	COG2068	MobA-Related Protein
M001_009885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M001_009885	COG0493	'glutamate synthase
M001_009890	COG0402	S-adenosylhomocysteine deaminase activity
M001_009895	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M001_009900	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M001_009900	COG2080	2 iron, 2 sulfur cluster binding
M001_009905	COG2233	PERMEase
M001_009910	COG0402	S-adenosylhomocysteine deaminase activity
M001_009915	COG2252	PERMEase
M001_009920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M001_009925	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M001_009930	COG2080	2 iron, 2 sulfur cluster binding
M001_009935	COG3134	Outer membrane lipoprotein
M001_009945	COG1288	antiporter activity
M001_009950	COG0318	PFAM AMP-dependent synthetase and ligase
M001_009955	COG3706	GGDEF domain
M001_009970	COG0107	imidazoleglycerol-phosphate synthase activity
M001_009975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M001_009980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M001_009985	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M001_009985	COG0131	Imidazoleglycerol-phosphate dehydratase
M001_009990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M001_009995	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M001_010000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M001_010010	COG1199	ATP-dependent helicase activity
M001_010015	COG1214	PFAM Peptidase M22, glycoprotease
M001_010025	COG2267	carboxylic ester hydrolase activity
M001_010030	COG0318	PFAM AMP-dependent synthetase and ligase
M001_010040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M001_010045	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
M001_010050	COG0709	Synthesizes selenophosphate from selenide and ATP
M001_010060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M001_010065	COG0840	transmembrane signaling receptor activity
M001_010070	COG1254	Belongs to the acylphosphatase family
M001_010080	COG3385	transposase activity
M001_010085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M001_010085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M001_010090	COG0489	protein tyrosine kinase activity
M001_010095	COG0572	uridine kinase
M001_010100	COG0717	Belongs to the dCTP deaminase family
M001_010105	COG0306	phosphate transporter
M001_010110	COG3313	Fe-S protein
M001_010115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M001_010120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M001_010125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M001_010130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M001_010140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M001_010150	COG0366	Alpha amylase catalytic
M001_010170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M001_010175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M001_010180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M001_010185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M001_010190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M001_010195	COG0072	phenylalanine-tRNA ligase activity
M001_010195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M001_010200	COG0776	regulation of translation
M001_010205	COG2205	protein histidine kinase activity
M001_010205	COG0784	Response regulator, receiver
M001_010230	COG2199	diguanylate cyclase activity
M001_010235	COG1609	Transcriptional regulator
M001_010240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M001_010245	COG1879	ABC-type sugar transport system periplasmic component
M001_010250	COG1172	Belongs to the binding-protein-dependent transport system permease family
M001_010255	COG1129	ABC transporter
M001_010260	COG1869	D-ribose catabolic process
M001_010265	COG0625	glutathione transferase activity
M001_010270	COG5654	RES domain protein
M001_010285	COG1177	transmembrane transport
M001_010310	COG0037	tRNA processing
M001_010315	COG0589	response to stress
M001_010320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M001_010335	COG2217	Heavy metal translocating P-type atpase
M001_010345	COG2010	Cytochrome c
M001_010360	COG3278	Belongs to the heme-copper respiratory oxidase family
M001_010370	COG1956	GAF domain-containing protein
M001_010375	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M001_010385	COG0308	aminopeptidase N
M001_010395	COG2902	Dehydrogenase
M001_010400	COG0167	dihydroorotate dehydrogenase activity
M001_010415	COG0254	rRNA binding
M001_010420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M001_010425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M001_010425	COG0116	Belongs to the methyltransferase superfamily
M001_010445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M001_010450	COG1067	ATP-dependent peptidase activity
M001_010495	COG4128	Pfam Zonular occludens toxin
M001_010530	COG3141	response to X-ray
M001_010535	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M001_010540	COG4221	oxidoreductase activity
M001_010580	COG3385	transposase activity
M001_010590	COG0372	Belongs to the citrate synthase family
M001_010595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M001_010605	COG2995	paraquat-inducible protein a
M001_010610	COG3008	intermembrane lipid transfer
M001_010615	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M001_010615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M001_010630	COG0084	hydrolase, TatD family'
M001_010635	COG0470	DNA polymerase III
M001_010640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M001_010645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M001_010650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M001_010655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M001_010660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M001_010665	COG1028	Short-chain dehydrogenase reductase Sdr
M001_010675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M001_010680	COG0416	fatty acid biosynthetic process
M001_010685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M001_010690	COG1399	metal-binding, possibly nucleic acid-binding protein
M001_010695	COG0424	maF-like protein
M001_010710	COG1530	ribonuclease E activity
M001_010720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_010720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_010720	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M001_010725	COG1105	Belongs to the carbohydrate kinase PfkB family
M001_010730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_010730	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_010735	COG1609	Transcriptional regulator
M001_010740	COG0814	amino acid
M001_010750	COG3788	relative of glutathione S-transferase, MAPEG superfamily
M001_010760	COG0513	Belongs to the DEAD box helicase family
M001_010770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M001_010775	COG2890	protein-(glutamine-N5) methyltransferase activity
M001_010780	COG2840	Smr protein MutS2
M001_010785	COG3706	GGDEF domain
M001_010790	COG0406	alpha-ribazole phosphatase activity
M001_010810	COG2824	Alkylphosphonate utilization operon protein PhnA
M001_010825	COG0494	nUDIX hydrolase
M001_010830	COG0814	amino acid
M001_010840	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M001_010845	COG0514	ATP-dependent DNA helicase (RecQ)
M001_010850	COG2766	serine protein kinase
M001_010855	COG2718	Belongs to the UPF0229 family
M001_010860	COG2719	SpoVR family
M001_010865	COG1250	3-hydroxyacyl-CoA dehydrogenase
M001_010865	COG1024	Enoyl-CoA hydratase
M001_010870	COG0183	Belongs to the thiolase family
M001_010875	COG0714	Associated with various cellular activities
M001_010895	COG2304	oxidoreductase activity
M001_010905	COG1595	DNA-templated transcription, initiation
M001_010915	COG2067	long-chain fatty acid transport protein
M001_010920	COG2067	long-chain fatty acid transport protein
M001_010925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M001_010940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M001_010950	COG1643	Atp-dependent helicase
M001_010955	COG0617	tRNA 3'-terminal CCA addition
M001_010955	COG0517	IMP dehydrogenase activity
M001_010955	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M001_010960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M001_010965	COG3119	arylsulfatase activity
M001_010970	COG0714	Associated with various cellular activities
M001_010985	COG2304	oxidoreductase activity
M001_010990	COG2304	oxidoreductase activity
M001_011015	COG0641	radical SAM
M001_011020	COG2925	Exonuclease
M001_011030	COG3345	alpha-galactosidase
M001_011035	COG1380	Effector of murein hydrolase LrgA
M001_011040	COG1346	cytolysis
M001_011045	COG0295	cytidine deaminase activity
M001_011050	COG3033	Beta-eliminating lyase
M001_011060	COG3046	protein related to deoxyribodipyrimidine photolyase
M001_011065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_011070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M001_011095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M001_011110	COG0454	-acetyltransferase
M001_011115	COG3158	transport of potassium into the cell
M001_011120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
M001_011125	COG0651	ATP synthesis coupled electron transport
M001_011130	COG0650	Formate hydrogenlyase subunit 4
M001_011135	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
M001_011135	COG3261	NADH dehydrogenase
M001_011140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_011145	COG3260	NADH ubiquinone oxidoreductase 20
M001_011155	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M001_011165	COG1921	L-seryl-tRNASec selenium transferase activity
M001_011175	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
M001_011180	COG0298	carbon dioxide binding
M001_011190	COG0309	Hydrogenase expression formation protein (HypE)
M001_011195	COG0375	protein maturation
M001_011200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M001_011205	COG1124	(ABC) transporter
M001_011215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M001_011220	COG0601	transmembrane transport
M001_011230	COG1773	rubredoxin
M001_011235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M001_011240	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
M001_011245	COG5557	Pfam Polysulphide reductase, NrfD
M001_011250	COG0437	4 iron, 4 sulfur cluster binding
M001_011255	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
M001_011260	COG5001	Diguanylate cyclase
M001_011260	COG4251	negative regulation of phosphorylation
M001_011260	COG3706	GGDEF domain
M001_011260	COG2203	Gaf domain
M001_011265	COG0438	transferase activity, transferring glycosyl groups
M001_011290	COG0438	transferase activity, transferring glycosyl groups
M001_011340	COG0438	transferase activity, transferring glycosyl groups
M001_011345	COG1215	transferase activity, transferring glycosyl groups
M001_011350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M001_011390	COG2205	protein histidine kinase activity
M001_011390	COG3437	response regulator, receiver
M001_011390	COG4999	Histidine kinase
M001_011390	COG3850	Histidine kinase
M001_011450	COG2003	Belongs to the UPF0758 family
M001_011475	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
M001_011565	COG0730	response to heat
M001_011575	COG1028	Short-chain dehydrogenase reductase Sdr
M001_011585	COG1024	Enoyl-CoA hydratase
M001_011590	COG1024	Enoyl-CoA hydratase
M001_011595	COG1960	acyl-CoA dehydrogenase activity
M001_011600	COG1960	acyl-CoA dehydrogenase activity
M001_011605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M001_011610	COG1024	Enoyl-CoA hydratase
M001_011640	COG1584	GPR1 FUN34 yaaH family protein
M001_011650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M001_011655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M001_011665	COG1073	alpha beta
M001_011670	COG0583	DNA-binding transcription factor activity
M001_011675	COG1073	alpha beta
M001_011690	COG1115	amino acid carrier protein
M001_011720	COG4695	Portal protein
M001_011725	COG1024	Enoyl-CoA hydratase
M001_011740	COG3162	membrane
M001_011745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M001_011750	COG0488	(ABC) transporter
M001_011755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M001_011760	COG0776	regulation of translation
M001_011765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M001_011770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M001_011775	COG0740	serine-type endopeptidase activity
M001_011780	COG0544	peptidyl-prolyl cis-trans isomerase activity
M001_011790	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M001_011795	COG4591	ABC-type transport system involved in lipoprotein release permease component
M001_011800	COG1136	(ABC) transporter
M001_011805	COG4591	ABC-type transport system involved in lipoprotein release permease component
M001_011815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M001_011820	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M001_011825	COG4166	transmembrane transport
M001_011830	COG0697	spore germination
M001_011840	COG2062	phosphohistidine phosphatase, SixA
M001_011845	COG1025	Belongs to the peptidase M16 family
M001_011890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M001_011890	COG0519	Catalyzes the synthesis of GMP from XMP
M001_011895	COG0517	IMP dehydrogenase activity
M001_011895	COG0516	GMP reductase activity
M001_011900	COG3038	cytochrome b561
M001_011905	COG1570	exodeoxyribonuclease VII activity
M001_011910	COG2188	Transcriptional regulator
M001_011915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_011915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_011915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_011920	COG0383	alpha-mannosidase activity
M001_011925	COG1181	Belongs to the D-alanine--D-alanine ligase family
M001_011935	COG0386	Belongs to the glutathione peroxidase family
M001_011940	COG0513	Belongs to the DEAD box helicase family
M001_011955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M001_011960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M001_011965	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M001_012015	COG3300	MHYT domain
M001_012015	COG5001	Diguanylate cyclase
M001_012030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M001_012040	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M001_012045	COG0563	adenylate kinase activity
M001_012055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M001_012060	COG1286	toxin biosynthetic process
M001_012070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M001_012075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M001_012080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M001_012085	COG0531	amino acid
M001_012085	COG1674	ftsk spoiiie
M001_012095	COG0686	Belongs to the AlaDH PNT family
M001_012100	COG0492	ferredoxin-NADP+ reductase activity
M001_012105	COG3706	GGDEF domain
M001_012110	COG3134	Outer membrane lipoprotein
M001_012115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M001_012120	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M001_012125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M001_012130	COG0542	response to heat
M001_012135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M001_012140	COG1278	Cold shock
M001_012145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M001_012165	COG0745	RESPONSE REGULATOR receiver
M001_012170	COG2205	protein histidine kinase activity
M001_012180	COG0392	lysyltransferase activity
M001_012180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M001_012275	COG0582	viral genome integration into host DNA
M001_012290	COG2169	Transcriptional regulator
M001_012360	COG1280	lysine exporter protein (LysE YggA)
M001_012370	COG3969	phosphoadenosine phosphosulfate
M001_012375	COG1475	DNA binding
M001_012395	COG2200	EAL domain
M001_012405	COG3039	Transposase
M001_012410	COG4409	exo-alpha-(2->6)-sialidase activity
M001_012415	COG2731	YhcH YjgK YiaL family protein
M001_012420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M001_012430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M001_012435	COG1737	Transcriptional regulator
M001_012475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M001_012480	COG0463	Glycosyl transferase, family 2
M001_012485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M001_012485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M001_012490	COG0726	polysaccharide deacetylase
M001_012495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M001_012500	COG2076	Multidrug Resistance protein
M001_012505	COG2076	Multidrug Resistance protein
M001_012525	COG4983	Phage plasmid primase, P4 family domain protein
M001_012570	COG2003	Belongs to the UPF0758 family
M001_012630	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M001_012635	COG1263	PTS System
M001_012635	COG2190	(PTS) system
M001_012635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_012650	COG0659	secondary active sulfate transmembrane transporter activity
M001_012675	COG0514	ATP-dependent DNA helicase (RecQ)
M001_012695	COG0672	)-iron permease
M001_012715	COG2814	Major facilitator Superfamily
M001_012730	COG1136	(ABC) transporter
M001_012755	COG0596	Alpha beta hydrolase
M001_012775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M001_012780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M001_012780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M001_012785	COG0527	aspartate kinase activity
M001_012795	COG1368	sulfuric ester hydrolase activity
M001_012800	COG1619	proteins homologs of microcin C7 resistance protein MccF
M001_012805	COG4667	esterase of the alpha-beta hydrolase superfamily
M001_012825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M001_012825	COG1648	precorrin-2 dehydrogenase activity
M001_012835	COG0393	Putative heavy-metal-binding
M001_012840	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M001_012845	COG0285	dihydrofolate synthase activity
M001_012850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M001_012855	COG0101	tRNA pseudouridine synthase activity
M001_012865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M001_012870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M001_012875	COG0671	phosphoesterase, PA-phosphatase related
M001_012880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M001_012885	COG2056	Na+-H+ antiporter family
M001_012890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M001_012890	COG0047	phosphoribosylformylglycinamidine synthase activity
M001_012895	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M001_012900	COG1645	bacterial-type flagellum-dependent swarming motility
M001_012905	COG1160	GTP binding
M001_012910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M001_012915	COG2976	Protein conserved in bacteria
M001_012920	COG0124	histidyl-tRNA synthetase
M001_012940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M001_012945	COG0105	UTP biosynthetic process
M001_012960	COG0633	Ferredoxin
M001_012965	COG0443	Heat shock 70 kDa protein
M001_012970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M001_012980	COG0822	iron-sulfur transferase activity
M001_012985	COG1104	cysteine desulfurase activity
M001_013005	COG3154	lipid carrier protein
M001_013010	COG0826	peptidase U32
M001_013015	COG0826	peptidase U32
M001_013030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M001_013035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M001_013040	COG1862	Preprotein translocase
M001_013045	COG0343	queuine tRNA-ribosyltransferase activity
M001_013050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M001_013055	COG0517	IMP dehydrogenase activity
M001_013065	COG3634	alkyl hydroperoxide reductase activity
M001_013120	COG1242	4 iron, 4 sulfur cluster binding
M001_013125	COG0070	glutamate synthase
M001_013125	COG0069	glutamate synthase activity
M001_013125	COG0067	glutamate synthase
M001_013130	COG0493	'glutamate synthase
M001_013140	COG0513	Belongs to the DEAD box helicase family
M001_013165	COG0023	Translation Initiation Factor
M001_013170	COG2119	membrane
M001_013205	COG1196	nuclear chromosome segregation
M001_013210	COG0215	cysteine-tRNA ligase activity
M001_013215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M001_013225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M001_013235	COG2261	transglycosylase associated protein
M001_013240	COG0642	Histidine kinase
M001_013270	COG4974	Belongs to the 'phage' integrase family
M001_013340	COG3596	GTP binding
M001_013345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M001_013370	COG4695	Portal protein
M001_013420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M001_013535	COG0322	excinuclease ABC activity
M001_013540	COG2197	response regulator
M001_013545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M001_013550	COG2835	tetraacyldisaccharide 4'-kinase activity
M001_013555	COG1663	tetraacyldisaccharide 4'-kinase activity
M001_013565	COG2333	competence protein COMEC
M001_013565	COG0658	competence protein
M001_013580	COG1448	Aminotransferase
M001_013590	COG0583	DNA-binding transcription factor activity
M001_013595	COG3085	chromosome segregation
M001_013600	COG4574	serine-type endopeptidase inhibitor activity
M001_013605	COG0584	glycerophosphoryl diester phosphodiesterase
M001_013615	COG1349	DNA-binding transcription factor activity
M001_013620	COG2271	Major facilitator Superfamily
M001_013625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M001_013630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M001_013635	COG0840	transmembrane signaling receptor activity
M001_013645	COG0583	DNA-binding transcription factor activity
M001_013660	COG3385	transposase activity
M001_013670	COG0656	L-ascorbic acid biosynthetic process
M001_013680	COG2814	Major facilitator Superfamily
M001_013685	COG2249	NAD(P)H dehydrogenase (quinone) activity
M001_013700	COG3220	belongs to the UPF0276 family
M001_013720	COG1294	oxidase, subunit
M001_013730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M001_013740	COG2979	Protein of unknown function (DUF533)
M001_013755	COG0583	DNA-binding transcription factor activity
M001_013760	COG2807	transmembrane transport
M001_013765	COG1187	pseudouridine synthase activity
M001_013775	COG0346	lactoylglutathione lyase activity
M001_013800	COG4657	Part of a membrane complex involved in electron transport
M001_013805	COG2878	Part of a membrane complex involved in electron transport
M001_013815	COG4658	electron transport chain
M001_013820	COG4659	FMN binding
M001_013825	COG4660	Part of a membrane complex involved in electron transport
M001_013830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M001_013835	COG0346	lactoylglutathione lyase activity
M001_013880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M001_013885	COG0505	Belongs to the CarA family
M001_013890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M001_013905	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M001_013910	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M001_013915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M001_013920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M001_013925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M001_013935	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
M001_013965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M001_013970	COG0861	Integral membrane protein TerC family
M001_013985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M001_013990	COG0601	transmembrane transport
M001_014000	COG2095	MarC family integral membrane protein
M001_014005	COG1454	alcohol dehydrogenase
M001_014005	COG1012	belongs to the aldehyde dehydrogenase family
M001_014015	COG0217	transcriptional regulatory protein
M001_014020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M001_014030	COG1801	Protein of unknown function DUF72
M001_014035	COG4106	trans-aconitate 2-methyltransferase activity
M001_014040	COG0500	methyltransferase
M001_014060	COG0450	alkyl hydroperoxide reductase
M001_014065	COG0583	DNA-binding transcription factor activity
M001_014070	COG0791	NLP P60 protein
M001_014080	COG0583	DNA-binding transcription factor activity
M001_014085	COG2610	gluconate transmembrane transporter activity
M001_014090	COG3048	D-serine ammonia-lyase activity
M001_014100	COG0538	isocitrate dehydrogenase activity
M001_014105	COG2207	Transcriptional regulator
M001_014115	COG0840	transmembrane signaling receptor activity
M001_014120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_014125	COG3385	transposase activity
M001_014140	COG3152	Membrane
M001_014175	COG1309	transcriptional regulator
M001_014185	COG1454	alcohol dehydrogenase
M001_014205	COG0534	Mate efflux family protein
M001_014215	COG2841	Protein conserved in bacteria
M001_014225	COG5001	Diguanylate cyclase
M001_014225	COG3300	MHYT domain
M001_014230	COG3132	Protein of unknown function, DUF480
M001_014260	COG0708	Exodeoxyribonuclease III
M001_014305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_014310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_014325	COG1120	ATPase activity
M001_014330	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M001_014335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M001_014340	COG2375	cellular response to nickel ion
M001_014345	COG0784	Response regulator, receiver
M001_014345	COG3437	response regulator, receiver
M001_014355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M001_014360	COG0328	RNA-DNA hybrid ribonuclease activity
M001_014365	COG2226	methyltransferase
M001_014370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M001_014375	COG0741	lytic transglycosylase activity
M001_014375	COG1388	LysM domain
M001_014400	COG5000	phosphorelay sensor kinase activity
M001_014400	COG5002	protein histidine kinase activity
M001_014405	COG0745	RESPONSE REGULATOR receiver
M001_014410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M001_014415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_014485	COG3209	COG3209 Rhs family protein
M001_014520	COG3501	Rhs element vgr protein
M001_014540	COG1388	LysM domain
M001_014540	COG1376	ErfK ybiS ycfS ynhG family protein
M001_014550	COG0471	metal ion transport
M001_014560	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
M001_014565	COG0791	NLP P60 protein
M001_014575	COG3118	belongs to the thioredoxin family
M001_014585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M001_014590	COG0788	formyltetrahydrofolate deformylase activity
M001_014600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M001_014615	COG3385	transposase activity
M001_014620	COG0739	heme binding
M001_014620	COG1196	nuclear chromosome segregation
M001_014620	COG0741	lytic transglycosylase activity
M001_014625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M001_014635	COG0436	Aminotransferase
M001_014640	COG1288	antiporter activity
M001_014645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M001_014660	COG2964	Protein conserved in bacteria
M001_014665	COG3681	Belongs to the UPF0597 family
M001_014675	COG0814	amino acid
M001_014695	COG1166	arginine decarboxylase activity
M001_014700	COG2195	Cleaves the N-terminal amino acid of tripeptides
M001_014725	COG2353	YceI-like domain
M001_014730	COG0583	DNA-binding transcription factor activity
M001_014740	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M001_014745	COG0840	transmembrane signaling receptor activity
M001_014750	COG0840	transmembrane signaling receptor activity
M001_014755	COG0302	gtp cyclohydrolase
M001_014760	COG0303	'Molybdopterin
M001_014765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M001_014780	COG2267	carboxylic ester hydrolase activity
M001_014785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M001_014800	COG0314	molybdopterin synthase activity
M001_014805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M001_014810	COG0315	cyclic pyranopterin monophosphate synthase activity
M001_014815	COG0521	Mo-molybdopterin cofactor biosynthetic process
M001_014820	COG3005	denitrification pathway
M001_014830	COG0348	domain, Protein
M001_014835	COG0437	4 iron, 4 sulfur cluster binding
M001_014840	COG0243	molybdopterin cofactor binding
M001_014850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M001_014855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M001_014860	COG3850	Histidine kinase
M001_014865	COG2197	response regulator
M001_014895	COG3385	transposase activity
M001_014900	COG0121	glutamine amidotransferase
M001_014905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M001_014910	COG1960	acyl-CoA dehydrogenase activity
M001_014915	COG1473	amidohydrolase
M001_014920	COG3385	transposase activity
M001_014930	COG2867	negative regulation of translational initiation
M001_014935	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M001_014945	COG2205	protein histidine kinase activity
M001_014945	COG0784	Response regulator, receiver
M001_014955	COG3383	formate dehydrogenase (NAD+) activity
M001_014970	COG0457	Tetratricopeptide repeat
M001_014975	COG1940	carbohydrate kinase activity
M001_014985	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M001_014995	COG1960	acyl-CoA dehydrogenase activity
M001_015000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M001_015010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M001_015015	COG1317	bacterial-type flagellum organization
M001_015105	COG0457	Tetratricopeptide repeat
M001_015175	COG4790	Type iii secretion
M001_015180	COG4794	Type iii secretion
M001_015185	COG4791	protein targeting
M001_015190	COG4792	protein secretion
M001_015205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M001_015210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M001_015210	COG1263	PTS System
M001_015215	COG1609	Transcriptional regulator
M001_015225	COG0456	acetyltransferase
M001_015250	COG0783	Belongs to the Dps family
M001_015275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_015275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_015275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_015280	COG2271	Major facilitator Superfamily
M001_015285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M001_015295	COG1187	pseudouridine synthase activity
M001_015305	COG0482	sulfurtransferase activity
M001_015310	COG2915	High frequency lysogenization protein hflD homolog
M001_015315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M001_015320	COG2850	peptidyl-arginine hydroxylation
M001_015325	COG3385	transposase activity
M001_015350	COG0259	pyridoxamine-phosphate oxidase activity
M001_015385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M001_015385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M001_015395	COG1882	Formate acetyltransferase
M001_015400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M001_015410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M001_015415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M001_015435	COG3088	subunit of a heme lyase
M001_015435	COG4235	cytochrome complex assembly
M001_015440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M001_015445	COG1138	Cytochrome C-type biogenesis protein
M001_015450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M001_015455	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M001_015460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M001_015465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M001_015480	COG0835	chemotaxis
M001_015490	COG1192	Involved in chromosome partitioning
M001_015495	COG1360	Flagellar Motor Protein
M001_015500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M001_015510	COG2198	Histidine kinase
M001_015510	COG0643	Histidine kinase
M001_015510	COG0784	Response regulator, receiver
M001_015515	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M001_015540	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M001_015550	COG1684	flagellar biosynthetic protein fliR
M001_015555	COG1987	bacterial-type flagellum assembly
M001_015605	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M001_015615	COG1677	Flagellar hook-basal body complex protein FliE
M001_015635	COG0469	pyruvate kinase activity
M001_015640	COG1737	Transcriptional regulator
M001_015645	COG0837	glucose binding
M001_015675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_015695	COG0281	malic enzyme
M001_015715	COG0437	4 iron, 4 sulfur cluster binding
M001_015720	COG3383	formate dehydrogenase (NAD+) activity
M001_015720	COG3383	formate dehydrogenase (NAD+) activity
M001_015755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M001_015765	COG3852	Histidine kinase
M001_015770	COG2204	response regulator
M001_015780	COG4662	Binding-protein-dependent transport system inner membrane component
M001_015790	COG0746	molybdenum cofactor guanylyltransferase activity
M001_015795	COG0303	'Molybdopterin
M001_015800	COG1289	transmembrane transporter activity
M001_015805	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M001_015835	COG3220	belongs to the UPF0276 family
M001_015865	COG0784	Response regulator, receiver
M001_015865	COG2205	protein histidine kinase activity
M001_015880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M001_015885	COG0444	Belongs to the ABC transporter superfamily
M001_015890	COG4608	Belongs to the ABC transporter superfamily
M001_015900	COG2971	BadF BadG BcrA BcrD
M001_015910	COG0840	transmembrane signaling receptor activity
M001_015930	COG3724	N-succinylarginine dihydrolase activity
M001_015960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M001_015970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M001_015975	COG3706	GGDEF domain
M001_015980	COG2211	Major facilitator Superfamily
M001_015985	COG0616	signal peptide processing
M001_015990	COG1028	Short-chain dehydrogenase reductase Sdr
M001_015995	COG0583	DNA-binding transcription factor activity
M001_016005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M001_016025	COG1881	PFAM PEBP family protein
M001_016035	COG3408	Glycogen debranching enzyme
M001_016035	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
M001_016045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M001_016060	COG1301	dicarboxylic acid transport
M001_016065	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M001_016070	COG2912	Transglutaminase-like superfamily
M001_016080	COG2890	protein-(glutamine-N5) methyltransferase activity
M001_016085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M001_016090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M001_016095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M001_016100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M001_016110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M001_016115	COG0737	Belongs to the 5'-nucleotidase family
M001_016120	COG0193	aminoacyl-tRNA hydrolase activity
M001_016125	COG0012	GTP binding
M001_016170	COG0471	metal ion transport
M001_016170	COG0490	domain, Protein
M001_016180	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M001_016205	COG2214	Heat shock protein DnaJ domain protein
M001_016210	COG0443	Heat shock 70 kDa protein
M001_016220	COG0366	Alpha amylase catalytic
M001_016225	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
M001_016225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M001_016225	COG1013	pyruvate-flavodoxin oxidoreductase activity
M001_016225	COG0674	pyruvate-flavodoxin oxidoreductase activity
M001_016235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M001_016250	COG1012	belongs to the aldehyde dehydrogenase family
M001_016260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M001_016275	COG0180	Tryptophanyl-tRNA synthetase
M001_016285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M001_016290	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M001_016300	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M001_016305	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M001_016335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M001_016340	COG0583	DNA-binding transcription factor activity
M001_016360	COG0583	DNA-binding transcription factor activity
M001_016370	COG0739	heme binding
M001_016380	COG1511	domain protein
M001_016380	COG3264	Mechanosensitive ion channel
M001_016385	COG0584	glycerophosphoryl diester phosphodiesterase
M001_016395	COG1053	succinate dehydrogenase
M001_016400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M001_016405	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M001_016410	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
M001_016415	COG3366	ferrous iron transmembrane transporter activity
M001_016420	COG0700	Nucleoside recognition
M001_016425	COG2195	Cleaves the N-terminal amino acid of tripeptides
M001_016435	COG3214	Protein conserved in bacteria
M001_016450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_016475	COG4221	oxidoreductase activity
M001_016490	COG0642	Histidine kinase
M001_016500	COG0516	GMP reductase activity
M001_016510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M001_016520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M001_016545	COG0583	DNA-binding transcription factor activity
M001_016550	COG3706	GGDEF domain
M001_016560	COG1335	isochorismatase
M001_016565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M001_016570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M001_016575	COG1702	phosphate starvation-inducible protein PhoH
M001_016580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M001_016585	COG4535	Mg2 and Co2 transporter CorC
M001_016590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M001_016595	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
M001_016605	COG0789	Transcriptional regulator
M001_016620	COG1970	mechanosensitive ion channel activity
M001_016630	COG4974	Belongs to the 'phage' integrase family
M001_016635	COG0716	FMN binding
M001_016640	COG0312	modulator of DNA gyrase
M001_016645	COG0312	modulator of DNA gyrase
M001_016650	COG2888	peptidyl-tyrosine sulfation
M001_016655	COG0495	leucyl-tRNA aminoacylation
M001_016670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M001_016675	COG0799	negative regulation of ribosome biogenesis
M001_016680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M001_016685	COG0768	penicillin binding
M001_016690	COG0772	Belongs to the SEDS family
M001_016695	COG2951	lytic endotransglycosylase activity
M001_016700	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M001_016705	COG1686	Belongs to the peptidase S11 family
M001_016710	COG2921	Belongs to the UPF0250 family
M001_016715	COG0321	lipoyl(octanoyl) transferase activity
M001_016720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M001_016740	COG3139	Protein of unknown function (DUF1315)
M001_016745	COG0252	asparaginase activity
M001_016750	COG0786	glutamate:sodium symporter activity
M001_016765	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M001_016770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M001_016775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M001_016790	COG3610	response to peptide
M001_016795	COG2966	Psort location CytoplasmicMembrane, score
M001_016805	COG0521	Mo-molybdopterin cofactor biosynthetic process
M001_016820	COG2897	thiosulfate sulfurtransferase activity
M001_016825	COG2066	Belongs to the glutaminase family
M001_016830	COG3171	Protein conserved in bacteria
M001_016835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M001_016840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M001_016845	COG2200	EAL domain
M001_016850	COG1090	epimerase
M001_016855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M001_016860	COG4181	ATPase activity
M001_016865	COG2755	lipolytic protein G-D-S-L family
M001_016870	COG0784	Response regulator, receiver
M001_016870	COG0835	chemotaxis
M001_016910	COG3397	chitin binding
M001_016925	COG3706	GGDEF domain
M001_016935	COG0784	Response regulator, receiver
M001_016935	COG2205	protein histidine kinase activity
M001_016935	COG5002	protein histidine kinase activity
M001_016945	COG3655	Transcriptional regulator
M001_016955	COG2814	Major facilitator Superfamily
M001_016990	COG3501	Rhs element vgr protein
M001_017025	COG0748	coenzyme F420 binding
M001_017030	COG3721	Heme iron utilization protein
M001_017040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M001_017055	COG3340	Belongs to the peptidase S51 family
M001_017065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M001_017080	COG0737	Belongs to the 5'-nucleotidase family
M001_017100	COG2204	response regulator
M001_017105	COG0545	Peptidyl-prolyl cis-trans isomerase
M001_017115	COG2900	Belongs to the SlyX family
M001_017120	COG1047	Peptidyl-prolyl cis-trans
M001_017125	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M001_017135	COG0835	chemotaxis
M001_017135	COG0784	Response regulator, receiver
M001_017140	COG0429	hydrolase of the alpha beta-hydrolase fold
M001_017145	COG4251	negative regulation of phosphorylation
M001_017145	COG3706	GGDEF domain
M001_017145	COG5001	Diguanylate cyclase
M001_017145	COG2203	Gaf domain
M001_017150	COG3089	Belongs to the UPF0270 family
M001_017155	COG3954	Phosphoribulokinase
M001_017170	COG1765	OsmC-like protein
M001_017210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M001_017215	COG2313	pseudouridylate synthase activity
M001_017240	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
M001_017260	COG2985	domain, Protein
M001_017260	COG0569	domain protein
M001_017265	COG1272	protein, Hemolysin III
M001_017270	COG0076	glutamate decarboxylase activity
M001_017275	COG2917	probably involved in intracellular septation
M001_017280	COG2350	Protein conserved in bacteria
M001_017290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M001_017295	COG1381	Involved in DNA repair and RecF pathway recombination
M001_017310	COG0681	Belongs to the peptidase S26 family
M001_017315	COG0481	GTPase activity
M001_017325	COG3026	antisigma factor binding
M001_017330	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
M001_017335	COG1595	DNA-templated transcription, initiation
M001_017340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M001_017350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M001_017355	COG0354	folic acid binding
M001_017380	COG4232	protein-disulfide reductase activity
M001_017400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M001_017405	COG0191	fructose-bisphosphate aldolase activity
M001_017410	COG0126	phosphoglycerate kinase activity
M001_017415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M001_017420	COG1940	carbohydrate kinase activity
M001_017425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M001_017430	COG2816	NAD+ diphosphatase activity
M001_017440	COG4991	sh3 domain protein
M001_017445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M001_017455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M001_017495	COG2816	NAD+ diphosphatase activity
M001_017535	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
M001_017545	COG2203	Gaf domain
M001_017545	COG2199	diguanylate cyclase activity
M001_017550	COG0513	Belongs to the DEAD box helicase family
M001_017580	COG0154	amidase activity
M001_017585	COG2957	Belongs to the agmatine deiminase family
M001_017595	COG2852	Protein conserved in bacteria
M001_017605	COG1902	pentaerythritol trinitrate reductase activity
M001_017620	COG1238	metal cluster binding
M001_017625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M001_017630	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M001_017635	COG0585	pseudouridine synthase activity
M001_017645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M001_017650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M001_017655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M001_017665	COG1376	ErfK ybiS ycfS ynhG family protein
M001_017670	COG0668	transmembrane transport
M001_017680	COG2731	YhcH YjgK YiaL family protein
M001_017690	COG1794	racemase activity, acting on amino acids and derivatives
M001_017705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M001_017720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M001_017720	COG0517	IMP dehydrogenase activity
M001_017720	COG0617	tRNA 3'-terminal CCA addition
M001_017725	COG0488	(ABC) transporter
M001_017735	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M001_017795	COG0148	phosphopyruvate hydratase activity
M001_017800	COG0504	CTP synthase activity
M001_017805	COG3956	TIGRFAM MazG family protein
M001_017810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M001_017815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M001_017825	COG4807	Protein conserved in bacteria
M001_017830	COG3023	N-Acetylmuramoyl-L-alanine amidase
M001_017835	COG0783	Belongs to the Dps family
M001_017840	COG1151	hydroxylamine reductase activity
M001_017845	COG1017	nitric oxide dioxygenase activity
M001_017845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M001_017850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M001_017855	COG0671	phosphoesterase, PA-phosphatase related
M001_017860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M001_017865	COG0163	prenyltransferase activity
M001_017880	COG1131	(ABC) transporter
M001_017885	COG0842	Transport permease protein
M001_017920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M001_017925	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M001_017930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M001_017940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M001_017945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M001_017950	COG1489	DNA binding
M001_017960	COG1643	Atp-dependent helicase
M001_017965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M001_017970	COG0346	lactoylglutathione lyase activity
M001_017975	COG2076	Multidrug Resistance protein
M001_017980	COG2076	Multidrug Resistance protein
M001_017990	COG0784	Response regulator, receiver
M001_017990	COG3437	response regulator, receiver
M001_017995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M001_018010	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M001_018025	COG1136	(ABC) transporter
M001_018045	COG0840	transmembrane signaling receptor activity
M001_018060	COG0529	Catalyzes the synthesis of activated sulfate
M001_018065	COG3273	potassium ion transport
M001_018065	COG0471	metal ion transport
M001_018070	COG2895	sulfate adenylyltransferase (ATP) activity
M001_018075	COG0175	sulfate reduction
M001_018080	COG1648	precorrin-2 dehydrogenase activity
M001_018080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M001_018085	COG0330	HflC and HflK could
M001_018090	COG1585	Membrane protein implicated in regulation of membrane protease activity
M001_018095	COG0840	transmembrane signaling receptor activity
M001_018100	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M001_018110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M001_018115	COG1640	4-alpha-glucanotransferase
M001_018120	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M001_018170	COG0561	phosphatase activity
M001_018185	COG0733	neurotransmitter:sodium symporter activity
M001_018195	COG0733	neurotransmitter:sodium symporter activity
M001_018260	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M001_018265	COG2885	chlorophyll binding
M001_018270	COG0823	Involved in the tonB-independent uptake of proteins
M001_018285	COG0811	peptide transport
M001_018290	COG0824	Thioesterase
M001_018295	COG3790	cyd operon protein YbgE
M001_018300	COG4890	Cyd operon protein YbgT
M001_018305	COG1294	oxidase, subunit
M001_018315	COG2255	four-way junction helicase activity
M001_018320	COG0632	four-way junction helicase activity
M001_018325	COG0840	transmembrane signaling receptor activity
M001_018335	COG2771	luxR family
M001_018350	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
M001_018355	COG2203	Gaf domain
M001_018355	COG5001	Diguanylate cyclase
M001_018355	COG3706	GGDEF domain
M001_018355	COG4251	negative regulation of phosphorylation
M001_018365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M001_018375	COG2995	paraquat-inducible protein a
M001_018380	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M001_018380	COG3008	intermembrane lipid transfer
M001_018390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M001_018395	COG0442	prolyl-tRNA aminoacylation
M001_018400	COG4221	oxidoreductase activity
M001_018415	COG1024	Enoyl-CoA hydratase
M001_018425	COG0110	maltose O-acetyltransferase activity
M001_018435	COG4166	transmembrane transport
M001_018445	COG0840	transmembrane signaling receptor activity
M001_018450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M001_018455	COG0735	belongs to the Fur family
M001_018480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M001_018485	COG0513	Belongs to the DEAD box helicase family
M001_018490	COG2153	protein acetylation
M001_018500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M001_018520	COG0557	exoribonuclease II activity
M001_018525	COG3706	GGDEF domain
M001_018530	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M001_018530	COG2885	chlorophyll binding
M001_018535	COG3240	lipase activity
M001_018540	COG3111	PFAM Bacterial OB fold (BOF) protein
M001_018550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M001_018555	COG1194	a g-specific adenine glycosylase
M001_018560	COG0617	tRNA 3'-terminal CCA addition
M001_018580	COG3068	Protein conserved in bacteria
M001_018590	COG0739	heme binding
M001_018610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M001_018615	COG1121	(ABC) transporter
M001_018620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M001_018625	COG0583	DNA-binding transcription factor activity
M001_018630	COG0697	spore germination
M001_018635	COG1573	uracil-dna glycosylase
M001_018650	COG2827	Endonuclease containing a URI domain
M001_018665	COG1842	Phage shock protein A
M001_018670	COG0204	Acyl-transferase
M001_018690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M001_018695	COG0583	DNA-binding transcription factor activity
M001_018705	COG1028	Short-chain dehydrogenase reductase Sdr
M001_018735	COG3104	oligopeptide transport
M001_018745	COG0583	DNA-binding transcription factor activity
M001_018765	COG3150	esterase
M001_018775	COG3151	Protein conserved in bacteria
M001_018780	COG0494	nUDIX hydrolase
M001_018785	COG1538	Outer membrane efflux protein
M001_018790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M001_018790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M001_018795	COG1560	Kdo2-lipid A biosynthetic process
M001_018800	COG2213	PTS system mannitol-specific
M001_018800	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M001_018805	COG0246	Mannitol dehydrogenase
M001_018810	COG3722	fumarate hydratase activity
M001_018820	COG0484	heat shock protein binding
M001_018840	COG1671	Belongs to the UPF0178 family
M001_018845	COG1988	membrane-bound metal-dependent
M001_018850	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M001_018855	COG0513	Belongs to the DEAD box helicase family
M001_018875	COG1575	Belongs to the MenA family. Type 1 subfamily
M001_018880	COG1169	isochorismate synthase
M001_018885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M001_018895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M001_018900	COG1441	menaquinone biosynthetic process
M001_018905	COG0318	PFAM AMP-dependent synthetase and ligase
M001_018910	COG3291	Pkd domain containing protein
M001_018915	COG2949	membrane
M001_018920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M001_018930	COG0835	chemotaxis
M001_018930	COG0784	Response regulator, receiver
M001_018940	COG1444	tRNA N-acetyltransferase activity
M001_018960	COG1803	Methylglyoxal synthase
M001_018965	COG1979	alcohol dehydrogenase
M001_018980	COG4221	oxidoreductase activity
M001_019020	COG1368	sulfuric ester hydrolase activity
M001_019025	COG1522	sequence-specific DNA binding
M001_019035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M001_019045	COG1058	Belongs to the CinA family
M001_019045	COG1546	Belongs to the CinA family
M001_019055	COG0561	phosphatase activity
M001_019065	COG2926	Belongs to the UPF0265 family
M001_019100	COG1396	sequence-specific DNA binding
M001_019105	COG3135	benzoate transporter
M001_019130	COG0840	transmembrane signaling receptor activity
M001_019140	COG3706	GGDEF domain
M001_019145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M001_019180	COG2197	response regulator
M001_019195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M001_019205	COG1278	Cold shock
M001_019210	COG2252	PERMEase
M001_019220	COG2376	Dihydroxyacetone kinase
M001_019225	COG1461	Dihydroxyacetone kinase
M001_019240	COG3284	Transcriptional regulator
M001_019255	COG0628	permease
M001_019275	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M001_019300	COG0456	acetyltransferase
M001_019305	COG3133	Outer membrane lipoprotein
M001_019310	COG0004	ammonium transporteR
M001_019315	COG3706	GGDEF domain
M001_019325	COG3932	Exopolysaccharide synthesis, ExoD
M001_019330	COG0814	amino acid
M001_019335	COG3706	GGDEF domain
M001_019345	COG0110	maltose O-acetyltransferase activity
M001_019365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M001_019370	COG2022	thiamine diphosphate biosynthetic process
M001_019380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M001_019385	COG0352	thiamine-phosphate diphosphorylase activity
M001_019390	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M001_019395	COG0754	glutathionylspermidine amidase activity
M001_019405	COG3766	membrane
M001_019425	COG0745	RESPONSE REGULATOR receiver
M001_019430	COG0642	Histidine kinase
M001_019435	COG0189	ligase activity
M001_019480	COG0477	Major facilitator Superfamily
M001_019495	COG0312	modulator of DNA gyrase
M001_019500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M001_019510	COG3164	Protein of unknown function
M001_019515	COG1530	ribonuclease E activity
M001_019520	COG0424	maF-like protein
M001_019525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M001_019530	COG1792	Involved in formation and maintenance of cell shape
M001_019535	COG1077	Cell shape determining protein MreB Mrl
M001_019560	COG4968	Prepilin-type N-terminal cleavage methylation domain
M001_019565	COG4969	Belongs to the N-Me-Phe pilin family
M001_019580	COG1459	type II secretion system
M001_019585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M001_019630	COG2199	diguanylate cyclase activity
M001_019630	COG2200	EAL domain
M001_019635	COG2200	EAL domain
M001_019640	COG0387	Pfam Sodium calcium exchanger
M001_019650	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M001_019655	COG0010	Belongs to the arginase family
M001_019660	COG1228	amidohydrolase
M001_019665	COG2188	Transcriptional regulator
M001_019670	COG0288	reversible hydration of carbon dioxide
M001_019680	COG2177	Part of the ABC transporter FtsEX involved in
M001_019685	COG2884	Cell division ATP-binding protein ftsE
M001_019690	COG0552	protein localization to endoplasmic reticulum
M001_019695	COG0742	ribosomal rna small subunit methyltransferase
M001_019720	COG2249	NAD(P)H dehydrogenase (quinone) activity
M001_019725	COG0583	DNA-binding transcription factor activity
M001_019730	COG4221	oxidoreductase activity
M001_019745	COG1770	oligopeptidase
M001_019760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M001_019770	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M001_019780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M001_019790	COG2095	MarC family integral membrane protein
M001_019800	COG1301	dicarboxylic acid transport
M001_019825	COG3714	YhhN family
M001_019885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M001_019890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M001_019895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M001_019900	COG0049	tRNA binding
M001_019905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M001_019910	COG2168	tRNA wobble position uridine thiolation
M001_019915	COG2923	Belongs to the DsrF TusC family
M001_019920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M001_019930	COG2964	Protein conserved in bacteria
M001_019935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M001_019940	COG0085	RNA polymerase activity
M001_019945	COG0222	ribosome binding
M001_019950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M001_019955	COG0081	regulation of translation
M001_019960	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M001_019965	COG0250	Participates in transcription elongation, termination and antitermination
M001_019980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M001_020005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M001_020010	COG0569	domain protein
M001_020015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M001_020035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M001_020045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M001_020045	COG4191	Histidine kinase
M001_020050	COG3005	denitrification pathway
M001_020055	COG0243	molybdopterin cofactor binding
M001_020065	COG2205	protein histidine kinase activity
M001_020070	COG0745	RESPONSE REGULATOR receiver
M001_020100	COG2204	response regulator
M001_020110	COG2205	protein histidine kinase activity
M001_020125	COG1028	Short-chain dehydrogenase reductase Sdr
M001_020130	COG0516	GMP reductase activity
M001_020130	COG0517	IMP dehydrogenase activity
M001_020135	COG5413	integral membrane protein
M001_020145	COG1522	sequence-specific DNA binding
M001_020150	COG2502	aspartate--ammonia ligase
M001_020155	COG0542	response to heat
M001_020165	COG0564	pseudouridine synthase activity
M001_020170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M001_020175	COG0446	pyridine nucleotide-disulphide oxidoreductase
M001_020185	COG3681	Belongs to the UPF0597 family
M001_020190	COG2964	Protein conserved in bacteria
M001_020200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M001_020205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M001_020210	COG1979	alcohol dehydrogenase
M001_020215	COG2207	Transcriptional regulator
M001_020220	COG3040	lipid binding
M001_020235	COG0583	DNA-binding transcription factor activity
M001_020255	COG0540	Belongs to the ATCase OTCase family
M001_020260	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
M001_020265	COG1438	arginine binding
M001_020270	COG1288	antiporter activity
M001_020275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M001_020305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M001_020315	COG3078	GTPase activator activity
M001_020325	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M001_020335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M001_020340	COG0408	coproporphyrinogen oxidase activity
M001_020345	COG0009	L-threonylcarbamoyladenylate synthase
M001_020355	COG0551	DNA topoisomerase type I activity
M001_020360	COG2922	Belongs to the Smg family
M001_020365	COG0758	DNA mediated transformation
M001_020370	COG1652	LysM domain
M001_020375	COG0242	peptide deformylase activity
M001_020380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M001_020385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M001_020385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M001_020390	COG0569	domain protein
M001_020395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M001_020405	COG0174	glutamine synthetase
M001_020420	COG2204	response regulator
M001_020425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M001_020430	COG1322	Protein conserved in bacteria
M001_020450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M001_020455	COG0583	DNA-binding transcription factor activity
M001_020460	COG0519	Catalyzes the synthesis of GMP from XMP
M001_020460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M001_020475	COG1396	sequence-specific DNA binding
M001_020480	COG1012	belongs to the aldehyde dehydrogenase family
M001_020490	COG2962	Rard protein
M001_020500	COG2391	methyltransferase activity
M001_020515	COG0129	dihydroxy-acid dehydratase activity
M001_020525	COG3978	acetolactate synthase activity
M001_020535	COG0606	chelatase, subunit chli
M001_020540	COG0204	Acyl-transferase
M001_020545	COG0204	Acyl-transferase
M001_020550	COG1683	Conserved Protein
M001_020560	COG1335	isochorismatase
M001_020570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M001_020575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M001_020585	COG3084	Protein conserved in bacteria
M001_020590	COG5001	Diguanylate cyclase
M001_020590	COG2203	Gaf domain
M001_020590	COG3706	GGDEF domain
M001_020590	COG4251	negative regulation of phosphorylation
M001_020605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M001_020610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M001_020615	COG1561	YicC-like family, N-terminal region
M001_020685	COG2197	response regulator
M001_020695	COG0739	heme binding
M001_020695	COG0741	lytic transglycosylase activity
M001_020695	COG1196	nuclear chromosome segregation
M001_020845	COG4977	sequence-specific DNA binding
M001_020885	COG0583	DNA-binding transcription factor activity
M001_020905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M001_020910	COG0385	Bile acid
M001_020915	COG0531	amino acid
M001_020920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M001_020925	COG0531	amino acid
M001_020930	COG2731	YhcH YjgK YiaL family protein
M001_020935	COG3250	beta-galactosidase activity
M001_020940	COG1609	Transcriptional regulator
M001_020975	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M001_020980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M001_020980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M001_020985	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
M001_020990	COG3074	FtsZ-dependent cytokinesis
M001_021000	COG1045	serine acetyltransferase
M001_021010	COG0745	RESPONSE REGULATOR receiver
M001_021015	COG2205	protein histidine kinase activity
M001_021020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M001_021025	COG0534	Mate efflux family protein
M001_021040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M001_021045	COG2937	Belongs to the GPAT DAPAT family
M001_021050	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M001_021055	COG3161	chorismate lyase activity
M001_021075	COG0604	alcohol dehydrogenase
M001_021080	COG1519	Transferase
M001_021085	COG0859	PFAM glycosyl transferase family 9
M001_021090	COG0463	Glycosyl transferase, family 2
M001_021095	COG0859	PFAM glycosyl transferase family 9
M001_021100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M001_021105	COG2990	Protein conserved in bacteria
M001_021110	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M001_021120	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M001_021125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M001_021130	COG2003	Belongs to the UPF0758 family
M001_021135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M001_021140	COG0756	dUTP diphosphatase activity
M001_021145	COG1309	transcriptional regulator
M001_021150	COG0668	transmembrane transport
M001_021155	COG0166	Belongs to the GPI family
M001_021160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M001_021180	COG1042	CoA-binding domain protein
M001_021180	COG0045	succinate-CoA ligase (ADP-forming) activity
M001_021180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M001_021210	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
M001_021215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M001_021220	COG1739	Uncharacterized protein family UPF0029
M001_021225	COG0006	proline dipeptidase activity
M001_021230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M001_021235	COG1024	Enoyl-CoA hydratase
M001_021235	COG1250	3-hydroxyacyl-CoA dehydrogenase
M001_021240	COG0183	Belongs to the thiolase family
M001_021245	COG0745	RESPONSE REGULATOR receiver
M001_021250	COG2205	protein histidine kinase activity
M001_021265	COG0425	Belongs to the sulfur carrier protein TusA family
M001_021270	COG0251	oxidation-reduction process
M001_021275	COG2885	chlorophyll binding
M001_021280	COG2818	Glycosylase
M001_021285	COG0752	glycyl-tRNA synthetase alpha subunit
M001_021290	COG0751	glycine-tRNA ligase activity
M001_021335	COG1609	Transcriptional regulator
M001_021365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M001_021380	COG2960	long-chain fatty acid transporting porin activity
M001_021385	COG5001	Diguanylate cyclase
M001_021395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M001_021410	COG3118	belongs to the thioredoxin family
M001_021415	COG0513	Belongs to the DEAD box helicase family
M001_021420	COG0248	Ppx GppA phosphatase
M001_021430	COG0742	ribosomal rna small subunit methyltransferase
M001_021445	COG3469	chitinase activity
M001_021450	COG3397	chitin binding
M001_021460	COG0084	hydrolase, TatD family'
M001_021465	COG0805	protein transport
M001_021470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M001_021475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M001_021480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M001_021485	COG3165	ubiquinone biosynthetic process from chorismate
M001_021490	COG2226	methyltransferase
M001_021495	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M001_021500	COG0402	S-adenosylhomocysteine deaminase activity
M001_021505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M001_021540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M001_021545	COG0848	biopolymer transport protein
M001_021550	COG0811	peptide transport
M001_021555	COG0811	peptide transport
M001_021565	COG2771	luxR family
M001_021570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M001_021575	COG1349	DNA-binding transcription factor activity
M001_021580	COG0745	RESPONSE REGULATOR receiver
M001_021585	COG2205	protein histidine kinase activity
M001_021600	COG4452	Inner membrane protein CreD
M001_021605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M001_021610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M001_021615	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M001_021620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M001_021625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M001_021630	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M001_021635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M001_021645	COG0356	it plays a direct role in the translocation of protons across the membrane
M001_021655	COG1475	DNA binding
M001_021660	COG1192	Involved in chromosome partitioning
M001_021665	COG0357	Ribosomal RNA small subunit methyltransferase G
M001_021670	COG0445	tRNA wobble uridine modification
M001_021675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M001_021685	COG4615	Cyclic peptide transporter
M001_021690	COG1120	ATPase activity
M001_021695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M001_021700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M001_021705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M001_021710	COG0706	membrane insertase activity
M001_021715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M001_021720	COG0594	ribonuclease P activity
M001_021725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M001_021875	COG0740	serine-type endopeptidase activity
M001_021915	COG3941	tape measure
M001_022025	COG1674	ftsk spoiiie
M001_022025	COG0531	amino acid