locus-tag	class	description
HXV88_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HXV88_00010	COG0592	DNA-directed DNA polymerase activity
HXV88_00020	COG0187	DNA topoisomerase II activity
HXV88_00030	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HXV88_00035	COG0071	Belongs to the small heat shock protein (HSP20) family
HXV88_00040	COG0071	Belongs to the small heat shock protein (HSP20) family
HXV88_00045	COG3977	Valine--pyruvate aminotransferase
HXV88_00060	COG2814	Major facilitator Superfamily
HXV88_00065	COG0745	RESPONSE REGULATOR receiver
HXV88_00070	COG2205	protein histidine kinase activity
HXV88_00090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXV88_00095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_00095	COG4191	Histidine kinase
HXV88_00100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_00105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_00110	COG1309	transcriptional regulator
HXV88_00140	COG0561	phosphatase activity
HXV88_00145	COG2267	carboxylic ester hydrolase activity
HXV88_00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXV88_00160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXV88_00165	COG1758	RNA polymerase activity
HXV88_00170	COG0194	GDP metabolic process
HXV88_00175	COG0859	PFAM glycosyl transferase family 9
HXV88_00180	COG3642	lipopolysaccharide core region biosynthetic process
HXV88_00220	COG0589	response to stress
HXV88_00225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXV88_00230	COG1528	Iron-storage protein
HXV88_00235	COG2081	HI0933 family
HXV88_00240	COG3275	phosphorelay sensor kinase activity
HXV88_00245	COG3279	Response regulator of the LytR AlgR family
HXV88_00250	COG2223	nitrite transmembrane transporter activity
HXV88_00255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HXV88_00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HXV88_00275	COG0583	DNA-binding transcription factor activity
HXV88_00315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HXV88_00320	COG2166	iron-sulfur cluster assembly
HXV88_00325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HXV88_00340	COG3245	cytochrome
HXV88_00345	COG1063	alcohol dehydrogenase
HXV88_00360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXV88_00380	COG3306	glycosyltransferase involved in LPS biosynthesis
HXV88_00415	COG1280	lysine exporter protein (LysE YggA)
HXV88_00460	COG0210	DNA helicase
HXV88_00485	COG2239	Acts as a magnesium transporter
HXV88_00490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_00490	COG1648	precorrin-2 dehydrogenase activity
HXV88_00495	COG2116	formate transmembrane transporter activity
HXV88_00505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXV88_00510	COG0842	Transport permease protein
HXV88_00515	COG0842	Transport permease protein
HXV88_00520	COG1131	(ABC) transporter
HXV88_00525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_00535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HXV88_00540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HXV88_00550	COG0018	arginyl-trna synthetase
HXV88_00560	COG1595	DNA-templated transcription, initiation
HXV88_00570	COG1968	undecaprenyl-diphosphatase activity
HXV88_00575	COG2017	converts alpha-aldose to the beta-anomer
HXV88_00580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HXV88_00585	COG1085	galactose-1-phosphate uridylyltransferase
HXV88_00590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXV88_00595	COG1609	Transcriptional regulator
HXV88_00600	COG3250	beta-galactosidase activity
HXV88_00610	COG1129	ABC transporter
HXV88_00615	COG4211	Belongs to the binding-protein-dependent transport system permease family
HXV88_00625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_00640	COG0366	Alpha amylase catalytic
HXV88_00655	COG0443	Heat shock 70 kDa protein
HXV88_00660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXV88_00665	COG3045	CreA protein
HXV88_00685	COG0174	glutamine synthetase
HXV88_00705	COG3842	ATPase activity
HXV88_00710	COG1176	ABC-type spermidine putrescine transport system, permease component I
HXV88_00715	COG1177	transmembrane transport
HXV88_00720	COG2258	MOSC domain
HXV88_00735	COG2050	protein possibly involved in aromatic compounds catabolism
HXV88_00740	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_00750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HXV88_00760	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HXV88_00765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXV88_00780	COG0254	rRNA binding
HXV88_00785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HXV88_00795	COG0702	epimerase
HXV88_00800	COG0814	amino acid
HXV88_00805	COG0281	malic enzyme
HXV88_00810	COG1295	ribonuclease BN
HXV88_00815	COG1490	D-aminoacyl-tRNA deacylase activity
HXV88_00820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HXV88_00825	COG0456	acetyltransferase
HXV88_00835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HXV88_00840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_00845	COG2610	gluconate transmembrane transporter activity
HXV88_00850	COG3265	gluconokinase activity
HXV88_00860	COG0800	Aldolase
HXV88_00865	COG1609	Transcriptional regulator
HXV88_00875	COG4942	peptidase
HXV88_00880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HXV88_00885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_00890	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HXV88_00895	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HXV88_00900	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HXV88_00900	COG0316	Belongs to the HesB IscA family
HXV88_00905	COG1040	competence protein
HXV88_00910	COG0596	Alpha beta hydrolase
HXV88_00930	COG2183	response to ionizing radiation
HXV88_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXV88_00940	COG0745	RESPONSE REGULATOR receiver
HXV88_00955	COG0051	transcription antitermination factor activity, RNA binding
HXV88_00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HXV88_00965	COG0088	Forms part of the polypeptide exit tunnel
HXV88_00970	COG0089	rRNA binding
HXV88_00975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HXV88_00980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HXV88_00985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HXV88_00990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HXV88_00995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HXV88_01000	COG0255	Belongs to the universal ribosomal protein uL29 family
HXV88_01005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HXV88_01010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HXV88_01015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HXV88_01020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HXV88_01025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HXV88_01030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HXV88_01035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HXV88_01040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HXV88_01045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HXV88_01050	COG1841	ribosomal large subunit assembly
HXV88_01055	COG0200	Binds to the 23S rRNA
HXV88_01060	COG0201	protein transport
HXV88_01065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXV88_01070	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HXV88_01075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HXV88_01080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HXV88_01085	COG0202	RNA polymerase activity
HXV88_01090	COG0203	ribosomal protein L17
HXV88_01120	COG4771	TonB-dependent receptor
HXV88_01125	COG3706	GGDEF domain
HXV88_01135	COG0745	RESPONSE REGULATOR receiver
HXV88_01145	COG0583	DNA-binding transcription factor activity
HXV88_01155	COG1741	Belongs to the pirin family
HXV88_01160	COG2259	Doxx family
HXV88_01165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HXV88_01170	COG1074	ATP-dependent DNA helicase activity
HXV88_01175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HXV88_01190	COG3706	GGDEF domain
HXV88_01220	COG1175	transmembrane transport
HXV88_01230	COG3842	ATPase activity
HXV88_01260	COG2873	o-acetylhomoserine
HXV88_01270	COG4533	DNA binding
HXV88_01290	COG5380	lipid catabolic process
HXV88_01295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HXV88_01300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXV88_01325	COG0753	catalase activity
HXV88_01355	COG2927	DNA polymerase III (CHI subunit)
HXV88_01360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HXV88_01365	COG0795	lipopolysaccharide-transporting ATPase activity
HXV88_01370	COG0795	lipopolysaccharide-transporting ATPase activity
HXV88_01425	COG1494	fructose-1,6-bisphosphatase
HXV88_01440	COG2959	enzyme of heme biosynthesis
HXV88_01450	COG0181	hydroxymethylbilane synthase activity
HXV88_01455	COG3072	Adenylate cyclase
HXV88_01460	COG0400	carboxylic ester hydrolase activity
HXV88_01465	COG1965	Belongs to the frataxin family
HXV88_01475	COG0019	diaminopimelate decarboxylase activity
HXV88_01480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HXV88_01495	COG1011	Hydrolase
HXV88_01515	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HXV88_01520	COG3028	Belongs to the UPF0307 family
HXV88_01525	COG0312	modulator of DNA gyrase
HXV88_01530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HXV88_01535	COG5007	Belongs to the BolA IbaG family
HXV88_01545	COG2854	intermembrane phospholipid transfer
HXV88_01550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXV88_01555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HXV88_01560	COG1127	ABC transporter
HXV88_01565	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HXV88_01565	COG0517	IMP dehydrogenase activity
HXV88_01570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HXV88_01575	COG3117	lipopolysaccharide transmembrane transporter activity
HXV88_01580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HXV88_01585	COG1137	ATPase activity
HXV88_01600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_01605	COG1660	Displays ATPase and GTPase activities
HXV88_01610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_01615	COG3711	transcriptional antiterminator
HXV88_01615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_01630	COG3964	amidohydrolase
HXV88_01660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXV88_01665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HXV88_01675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HXV88_01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HXV88_01685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HXV88_01690	COG0723	plastoquinol--plastocyanin reductase activity
HXV88_01695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HXV88_01700	COG2857	Cytochrome c1
HXV88_01705	COG0625	glutathione transferase activity
HXV88_01710	COG2969	positive regulation of protein catabolic process
HXV88_01720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HXV88_01725	COG0792	nuclease activity
HXV88_01730	COG3107	peptidoglycan biosynthetic process
HXV88_01735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HXV88_01760	COG1987	bacterial-type flagellum assembly
HXV88_01785	COG1677	Flagellar hook-basal body complex protein FliE
HXV88_01795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXV88_01825	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HXV88_01830	COG1815	bacterial-type flagellum-dependent cell motility
HXV88_01845	COG1749	Flagellar hook protein flgE
HXV88_01850	COG4787	bacterial-type flagellum-dependent cell motility
HXV88_01855	COG4786	Flagellar basal body rod
HXV88_01860	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HXV88_01865	COG1706	bacterial-type flagellum-dependent cell motility
HXV88_01875	COG1256	bacterial-type flagellum assembly
HXV88_01875	COG4786	Flagellar basal body rod
HXV88_01880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_01900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_01905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HXV88_01930	COG1191	sigma factor activity
HXV88_01935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_01950	COG0741	lytic transglycosylase activity
HXV88_01950	COG1388	LysM domain
HXV88_01955	COG2001	Belongs to the MraZ family
HXV88_01960	COG0275	rRNA processing
HXV88_01965	COG3116	cell division
HXV88_01970	COG0768	penicillin binding
HXV88_01980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HXV88_01985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HXV88_01990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HXV88_01995	COG0772	Belongs to the SEDS family
HXV88_02000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HXV88_02005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXV88_02015	COG0849	cell division
HXV88_02020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HXV88_02025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HXV88_02035	COG0653	protein targeting
HXV88_02040	COG0494	nUDIX hydrolase
HXV88_02045	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HXV88_02050	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HXV88_02060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HXV88_02065	COG1459	type II secretion system
HXV88_02070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_02095	COG2186	Transcriptional regulator
HXV88_02100	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HXV88_02105	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXV88_02110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HXV88_02120	COG0840	transmembrane signaling receptor activity
HXV88_02125	COG1752	Esterase of the alpha-beta hydrolase superfamily
HXV88_02130	COG1049	propionate catabolic process, 2-methylcitrate cycle
HXV88_02135	COG2200	EAL domain
HXV88_02145	COG0523	cobalamin synthesis protein
HXV88_02150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_02165	COG0477	Major facilitator Superfamily
HXV88_02180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HXV88_02185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HXV88_02280	COG2314	TM2 domain
HXV88_02320	COG3121	Chaperone
HXV88_02325	COG3188	usher protein
HXV88_02335	COG2200	EAL domain
HXV88_02365	COG0165	Argininosuccinate lyase
HXV88_02370	COG0137	argininosuccinate synthase activity
HXV88_02380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXV88_02385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HXV88_02395	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HXV88_02400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HXV88_02410	COG0583	DNA-binding transcription factor activity
HXV88_02415	COG1380	Effector of murein hydrolase LrgA
HXV88_02420	COG1346	cytolysis
HXV88_02430	COG4667	esterase of the alpha-beta hydrolase superfamily
HXV88_02435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HXV88_02440	COG1546	Belongs to the CinA family
HXV88_02445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HXV88_02455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXV88_02460	COG0527	aspartate kinase activity
HXV88_02465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HXV88_02500	COG1686	Belongs to the peptidase S11 family
HXV88_02505	COG0586	Pfam SNARE associated Golgi protein
HXV88_02510	COG1253	flavin adenine dinucleotide binding
HXV88_02515	COG0252	asparaginase activity
HXV88_02535	COG1263	PTS System
HXV88_02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_02540	COG0366	Alpha amylase catalytic
HXV88_02545	COG0110	maltose O-acetyltransferase activity
HXV88_02555	COG0564	pseudouridine synthase activity
HXV88_02560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HXV88_02590	COG2926	Belongs to the UPF0265 family
HXV88_02600	COG0561	phosphatase activity
HXV88_02610	COG1058	Belongs to the CinA family
HXV88_02610	COG1546	Belongs to the CinA family
HXV88_02620	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HXV88_02630	COG1522	sequence-specific DNA binding
HXV88_02635	COG1368	sulfuric ester hydrolase activity
HXV88_02675	COG4221	oxidoreductase activity
HXV88_02690	COG1979	alcohol dehydrogenase
HXV88_02695	COG1803	Methylglyoxal synthase
HXV88_02715	COG1444	tRNA N-acetyltransferase activity
HXV88_02720	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_02725	COG0784	Response regulator, receiver
HXV88_02725	COG0835	chemotaxis
HXV88_02735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HXV88_02740	COG2949	membrane
HXV88_02745	COG3291	Pkd domain containing protein
HXV88_02750	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_02755	COG1441	menaquinone biosynthetic process
HXV88_02760	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HXV88_02765	COG0596	Alpha beta hydrolase
HXV88_02770	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HXV88_02775	COG1169	isochorismate synthase
HXV88_02780	COG1575	Belongs to the MenA family. Type 1 subfamily
HXV88_02805	COG0513	Belongs to the DEAD box helicase family
HXV88_02810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_02815	COG1988	membrane-bound metal-dependent
HXV88_02820	COG1671	Belongs to the UPF0178 family
HXV88_02840	COG0484	heat shock protein binding
HXV88_02845	COG3263	regulation of cellular component size
HXV88_02850	COG3722	fumarate hydratase activity
HXV88_02855	COG0246	Mannitol dehydrogenase
HXV88_02860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_02860	COG2213	PTS system mannitol-specific
HXV88_02865	COG1560	Kdo2-lipid A biosynthetic process
HXV88_02870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HXV88_02870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HXV88_02875	COG1538	Outer membrane efflux protein
HXV88_02880	COG0494	nUDIX hydrolase
HXV88_02885	COG3151	Protein conserved in bacteria
HXV88_02895	COG3150	esterase
HXV88_02920	COG3104	oligopeptide transport
HXV88_02955	COG0583	DNA-binding transcription factor activity
HXV88_02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXV88_02980	COG0204	Acyl-transferase
HXV88_02985	COG1842	Phage shock protein A
HXV88_03000	COG2827	Endonuclease containing a URI domain
HXV88_03015	COG1573	uracil-dna glycosylase
HXV88_03020	COG0697	spore germination
HXV88_03025	COG0583	DNA-binding transcription factor activity
HXV88_03030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HXV88_03035	COG1121	(ABC) transporter
HXV88_03040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HXV88_03060	COG0739	heme binding
HXV88_03070	COG3068	Protein conserved in bacteria
HXV88_03075	COG3385	transposase activity
HXV88_03080	COG4536	flavin adenine dinucleotide binding
HXV88_03085	COG4137	Cytochrome C assembly protein
HXV88_03090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HXV88_03095	COG0228	four-way junction DNA binding
HXV88_03100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HXV88_03105	COG0336	Belongs to the RNA methyltransferase TrmD family
HXV88_03110	COG0335	large ribosomal subunit rRNA binding
HXV88_03120	COG3066	DNA modification
HXV88_03125	COG1051	belongs to the nudix hydrolase family
HXV88_03135	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HXV88_03140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HXV88_03145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_03155	COG0583	DNA-binding transcription factor activity
HXV88_03160	COG0640	Transcriptional regulator
HXV88_03165	COG0268	Binds directly to 16S ribosomal RNA
HXV88_03170	COG0728	peptidoglycan biosynthetic process
HXV88_03175	COG0196	riboflavin kinase activity
HXV88_03180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HXV88_03185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HXV88_03190	COG1047	Peptidyl-prolyl cis-trans
HXV88_03195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HXV88_03240	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HXV88_03240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXV88_03255	COG1854	S-ribosylhomocysteine lyase activity
HXV88_03265	COG4968	Prepilin-type N-terminal cleavage methylation domain
HXV88_03270	COG0084	hydrolase, TatD family'
HXV88_03275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_03285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXV88_03290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_03295	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HXV88_03300	COG0813	purine-nucleoside phosphorylase activity
HXV88_03310	COG0560	Phosphoserine phosphatase
HXV88_03325	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HXV88_03340	COG0776	regulation of translation
HXV88_03350	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HXV88_03355	COG1914	H( )-stimulated, divalent metal cation uptake system
HXV88_03360	COG0360	Binds together with S18 to 16S ribosomal RNA
HXV88_03365	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HXV88_03370	COG0359	binds to the 23S rRNA
HXV88_03375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_03400	COG1064	alcohol dehydrogenase
HXV88_03405	COG1238	metal cluster binding
HXV88_03410	COG0612	Peptidase, M16
HXV88_03415	COG2918	glutathione biosynthetic process
HXV88_03420	COG1022	Amp-dependent synthetase and ligase
HXV88_03430	COG0456	acetyltransferase
HXV88_03445	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HXV88_03455	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_03470	COG0477	Major facilitator Superfamily
HXV88_03475	COG0583	DNA-binding transcription factor activity
HXV88_03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_03490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_03500	COG0673	inositol 2-dehydrogenase activity
HXV88_03510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HXV88_03515	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXV88_03520	COG3036	rescue of stalled ribosome
HXV88_03530	COG0138	bifunctional purine biosynthesis protein purh
HXV88_03535	COG0151	Belongs to the GarS family
HXV88_03555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HXV88_03565	COG1610	YqeY-like protein
HXV88_03570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HXV88_03575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HXV88_03580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HXV88_03585	COG1027	Aspartate ammonia-lyase
HXV88_03590	COG3030	protein affecting phage T7 exclusion by the F plasmid
HXV88_03595	COG0534	Mate efflux family protein
HXV88_03600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HXV88_03605	COG0459	protein refolding
HXV88_03670	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HXV88_03675	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HXV88_03685	COG4143	(ABC) transporter
HXV88_03700	COG0066	3-isopropylmalate dehydratase activity
HXV88_03705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HXV88_03710	COG0473	3-isopropylmalate dehydrogenase activity
HXV88_03715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HXV88_03740	COG0028	Belongs to the TPP enzyme family
HXV88_03745	COG0440	acetolactate synthase activity
HXV88_03760	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HXV88_03775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_03805	COG0745	RESPONSE REGULATOR receiver
HXV88_03810	COG3104	oligopeptide transport
HXV88_03815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HXV88_03820	COG1555	photosystem II stabilization
HXV88_03825	COG0857	belongs to the CobB CobQ family
HXV88_03825	COG0280	phosphate acetyltransferase
HXV88_03830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXV88_03840	COG3013	Belongs to the UPF0304 family
HXV88_03845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HXV88_03850	COG2716	regulation of RNA biosynthetic process
HXV88_03855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXV88_03860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HXV88_03865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HXV88_03875	COG0583	DNA-binding transcription factor activity
HXV88_03900	COG5002	protein histidine kinase activity
HXV88_03900	COG2198	Histidine kinase
HXV88_03900	COG0784	Response regulator, receiver
HXV88_03925	COG0840	transmembrane signaling receptor activity
HXV88_03935	COG1464	Belongs to the NlpA lipoprotein family
HXV88_03940	COG2011	ABC-type metal ion transport system permease component
HXV88_03945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HXV88_03965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HXV88_03965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HXV88_03970	COG0802	atpase or kinase
HXV88_03980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXV88_03985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HXV88_03990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HXV88_03995	COG1923	regulation of RNA biosynthetic process
HXV88_04000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HXV88_04005	COG0330	HflC and HflK could
HXV88_04010	COG0330	HflC and HflK could
HXV88_04015	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HXV88_04020	COG0142	geranyltranstransferase activity
HXV88_04025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HXV88_04030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HXV88_04035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HXV88_04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HXV88_04075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HXV88_04080	COG2967	ApaG domain
HXV88_04085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HXV88_04090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HXV88_04095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_04100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HXV88_04105	COG3178	'Phosphotransferase
HXV88_04110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HXV88_04115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HXV88_04120	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_04125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HXV88_04145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HXV88_04160	COG2350	Protein conserved in bacteria
HXV88_04165	COG2917	probably involved in intracellular septation
HXV88_04170	COG0076	glutamate decarboxylase activity
HXV88_04175	COG1272	protein, Hemolysin III
HXV88_04180	COG2985	domain, Protein
HXV88_04180	COG0569	domain protein
HXV88_04200	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HXV88_04225	COG2264	protein methyltransferase activity
HXV88_04230	COG0604	alcohol dehydrogenase
HXV88_04235	COG0583	DNA-binding transcription factor activity
HXV88_04240	COG2190	(PTS) system
HXV88_04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_04240	COG1263	PTS System
HXV88_04245	COG4145	pantothenate transmembrane transporter activity
HXV88_04255	COG0439	Biotin carboxylase
HXV88_04260	COG0511	ligase activity, forming carbon-carbon bonds
HXV88_04265	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HXV88_04270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXV88_04290	COG3381	protein complex oligomerization
HXV88_04300	COG3005	denitrification pathway
HXV88_04305	COG0745	RESPONSE REGULATOR receiver
HXV88_04315	COG1879	ABC-type sugar transport system periplasmic component
HXV88_04320	COG0784	Response regulator, receiver
HXV88_04320	COG2198	Histidine kinase
HXV88_04320	COG2205	protein histidine kinase activity
HXV88_04330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HXV88_04335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HXV88_04340	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXV88_04340	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HXV88_04355	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HXV88_04360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_04365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HXV88_04370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HXV88_04395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HXV88_04400	COG0142	geranyltranstransferase activity
HXV88_04405	COG1722	exodeoxyribonuclease VII activity
HXV88_04410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_04415	COG1360	Flagellar Motor Protein
HXV88_04430	COG1534	Rna-binding protein
HXV88_04435	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HXV88_04445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HXV88_04450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HXV88_04455	COG0149	triose-phosphate isomerase activity
HXV88_04460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HXV88_04475	COG0779	Required for maturation of 30S ribosomal subunits
HXV88_04480	COG0195	Participates in both transcription termination and antitermination
HXV88_04485	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HXV88_04490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HXV88_04495	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HXV88_04500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HXV88_04505	COG1185	polyribonucleotide nucleotidyltransferase activity
HXV88_04510	COG2201	protein-glutamate methylesterase activity
HXV88_04515	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HXV88_04525	COG0840	transmembrane signaling receptor activity
HXV88_04530	COG0835	chemotaxis
HXV88_04540	COG2198	Histidine kinase
HXV88_04540	COG0643	Histidine kinase
HXV88_04550	COG0745	RESPONSE REGULATOR receiver
HXV88_04570	COG1280	lysine exporter protein (LysE YggA)
HXV88_04575	COG0826	peptidase U32
HXV88_04580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HXV88_04620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HXV88_04645	COG0300	oxidoreductase activity
HXV88_04655	COG0840	transmembrane signaling receptor activity
HXV88_04670	COG3501	Rhs element vgr protein
HXV88_04715	COG1605	Chorismate mutase
HXV88_04715	COG0077	Prephenate dehydratase
HXV88_04745	COG3272	Protein of unknown function (DUF1722)
HXV88_04750	COG0789	Transcriptional regulator
HXV88_04755	COG0415	Belongs to the DNA photolyase family
HXV88_04765	COG0300	oxidoreductase activity
HXV88_04780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HXV88_04810	COG1477	protein flavinylation
HXV88_04815	COG2871	sodium ion transport
HXV88_04820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_04825	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_04830	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_04835	COG1805	sodium ion transport
HXV88_04840	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HXV88_04845	COG0271	Belongs to the BolA IbaG family
HXV88_04850	COG2813	Specifically methylates the guanine in position
HXV88_04860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXV88_04865	COG2211	Major facilitator Superfamily
HXV88_04875	COG1666	GTP binding
HXV88_04880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HXV88_04895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_04900	COG0840	transmembrane signaling receptor activity
HXV88_04905	COG0583	DNA-binding transcription factor activity
HXV88_04915	COG2363	Small membrane protein
HXV88_04920	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HXV88_04930	COG0473	3-isopropylmalate dehydrogenase activity
HXV88_04935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_04940	COG1611	Belongs to the LOG family
HXV88_04945	COG3706	GGDEF domain
HXV88_04955	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HXV88_04955	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HXV88_04965	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HXV88_04990	COG3098	single-species biofilm formation
HXV88_04995	COG0564	pseudouridine synthase activity
HXV88_05015	COG1263	PTS System
HXV88_05015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_05025	COG2171	N-acyltransferase activity
HXV88_05035	COG0024	Methionine aminopeptidase
HXV88_05040	COG0052	Belongs to the universal ribosomal protein uS2 family
HXV88_05045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HXV88_05050	COG0528	UMP kinase activity
HXV88_05055	COG0233	cytoplasmic translational termination
HXV88_05060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HXV88_05065	COG0575	Belongs to the CDS family
HXV88_05070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HXV88_05075	COG0750	zinc metalloprotease
HXV88_05090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_05095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_05100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_05105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_05110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HXV88_05120	COG0825	malonyl-CoA metabolic process
HXV88_05130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXV88_05135	COG1115	amino acid carrier protein
HXV88_05150	COG0714	Associated with various cellular activities
HXV88_05165	COG3104	oligopeptide transport
HXV88_05170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HXV88_05175	COG1678	Uncharacterized ACR, COG1678
HXV88_05180	COG0189	ligase activity
HXV88_05185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HXV88_05195	COG3091	SprT-like family
HXV88_05205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HXV88_05215	COG0251	oxidation-reduction process
HXV88_05230	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HXV88_05235	COG0739	heme binding
HXV88_05240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HXV88_05270	COG0814	amino acid
HXV88_05290	COG0531	amino acid
HXV88_05295	COG3710	Transcriptional regulator
HXV88_05300	COG0531	amino acid
HXV88_05305	COG1982	Orn Lys Arg decarboxylase major
HXV88_05310	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HXV88_05320	COG3590	peptidase
HXV88_05330	COG2199	diguanylate cyclase activity
HXV88_05330	COG2203	Gaf domain
HXV88_05365	COG0366	Alpha amylase catalytic
HXV88_05380	COG0463	Glycosyl transferase, family 2
HXV88_05395	COG2989	Protein conserved in bacteria
HXV88_05400	COG3108	Peptidase M15
HXV88_05410	COG2860	membrane
HXV88_05420	COG1196	nuclear chromosome segregation
HXV88_05425	COG3115	cell septum assembly
HXV88_05430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HXV88_05440	COG1328	CTP reductase activity
HXV88_05445	COG0602	queuosine metabolic process
HXV88_05475	COG1566	PFAM secretion protein HlyD family protein
HXV88_05480	COG1846	Transcriptional regulator
HXV88_05490	COG0281	malic enzyme
HXV88_05495	COG3290	protein histidine kinase activity
HXV88_05505	COG0697	spore germination
HXV88_05520	COG0346	lactoylglutathione lyase activity
HXV88_05525	COG0745	RESPONSE REGULATOR receiver
HXV88_05530	COG5002	protein histidine kinase activity
HXV88_05555	COG3142	Participates in the control of copper homeostasis
HXV88_05560	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_05585	COG0678	peroxiredoxin activity
HXV88_05595	COG0019	diaminopimelate decarboxylase activity
HXV88_05600	COG1115	amino acid carrier protein
HXV88_05605	COG0095	Lipoate-protein ligase
HXV88_05610	COG2233	PERMEase
HXV88_05615	COG3706	GGDEF domain
HXV88_05625	COG0534	Mate efflux family protein
HXV88_05635	COG0281	malic enzyme
HXV88_05665	COG0531	amino acid
HXV88_05670	COG1752	Esterase of the alpha-beta hydrolase superfamily
HXV88_05675	COG3706	GGDEF domain
HXV88_05680	COG1566	PFAM secretion protein HlyD family protein
HXV88_05690	COG1032	radical SAM domain protein
HXV88_05720	COG0583	DNA-binding transcription factor activity
HXV88_05725	COG0673	inositol 2-dehydrogenase activity
HXV88_05730	COG2920	part of a sulfur-relay system
HXV88_05735	COG1289	transmembrane transporter activity
HXV88_05740	COG0670	Belongs to the BI1 family
HXV88_05755	COG0003	Pfam Anion-transporting ATPase
HXV88_05840	COG3775	system Galactitol-specific IIC component
HXV88_05850	COG1484	DNA-dependent DNA replication
HXV88_05865	COG2003	Belongs to the UPF0758 family
HXV88_05905	COG4983	Phage plasmid primase, P4 family domain protein
HXV88_05910	COG3311	Transcriptional regulator
HXV88_05975	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HXV88_05985	COG3501	Rhs element vgr protein
HXV88_05995	COG4104	PAAR repeat-containing protein
HXV88_05995	COG3209	COG3209 Rhs family protein
HXV88_06010	COG0582	viral genome integration into host DNA
HXV88_06020	COG3623	hexulose-6-phosphate isomerase
HXV88_06025	COG0561	phosphatase activity
HXV88_06050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HXV88_06060	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HXV88_06070	COG3156	type II secretion system protein K
HXV88_06075	COG4795	General secretion pathway protein
HXV88_06080	COG2165	general secretion pathway protein
HXV88_06090	COG2165	general secretion pathway protein
HXV88_06095	COG1459	type II secretion system
HXV88_06100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_06105	COG1450	Type ii and iii secretion system protein
HXV88_06120	COG3409	Peptidoglycan-binding domain 1 protein
HXV88_06120	COG3267	Type II secretory pathway component ExeA
HXV88_06125	COG2770	Histidine kinase
HXV88_06125	COG3437	response regulator, receiver
HXV88_06140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HXV88_06145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HXV88_06150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_06160	COG2190	(PTS) system
HXV88_06165	COG3706	GGDEF domain
HXV88_06170	COG3590	peptidase
HXV88_06180	COG1196	nuclear chromosome segregation
HXV88_06180	COG3264	Mechanosensitive ion channel
HXV88_06185	COG0469	pyruvate kinase activity
HXV88_06195	COG3384	dioxygenase
HXV88_06200	COG0419	ATPase involved in DNA repair
HXV88_06205	COG0420	3'-5' exonuclease activity
HXV88_06215	COG2974	May be involved in recombination
HXV88_06220	COG0405	Gamma-glutamyltransferase
HXV88_06225	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_06230	COG1283	sodium-dependent phosphate transmembrane transporter activity
HXV88_06240	COG0531	amino acid
HXV88_06250	COG0531	amino acid
HXV88_06265	COG1396	sequence-specific DNA binding
HXV88_06265	COG1917	Cupin 2, conserved barrel domain protein
HXV88_06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_06290	COG2862	Uncharacterized protein family, UPF0114
HXV88_06300	COG0745	RESPONSE REGULATOR receiver
HXV88_06310	COG3038	cytochrome b561
HXV88_06315	COG1720	tRNA m6t6A37 methyltransferase activity
HXV88_06335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HXV88_06340	COG4988	ABC transporter
HXV88_06355	COG0745	RESPONSE REGULATOR receiver
HXV88_06365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HXV88_06395	COG0798	PFAM Bile acid sodium symporter
HXV88_06400	COG1393	Belongs to the ArsC family
HXV88_06405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_06425	COG1988	membrane-bound metal-dependent
HXV88_06445	COG0159	tryptophan synthase activity
HXV88_06450	COG0133	tryptophan synthase activity
HXV88_06455	COG0134	indole-3-glycerol-phosphate synthase activity
HXV88_06455	COG0135	phosphoribosylanthranilate isomerase activity
HXV88_06460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXV88_06465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HXV88_06465	COG0512	Glutamine amidotransferase of anthranilate synthase
HXV88_06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HXV88_06480	COG0009	L-threonylcarbamoyladenylate synthase
HXV88_06490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HXV88_06505	COG3210	domain, Protein
HXV88_06525	COG1946	Acyl-CoA thioesterase
HXV88_06530	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HXV88_06535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HXV88_06545	COG0083	homoserine kinase activity
HXV88_06550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HXV88_06575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXV88_06595	COG1342	Belongs to the UPF0251 family
HXV88_06610	COG1309	transcriptional regulator
HXV88_06615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_06620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_06635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_06640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HXV88_06645	COG2089	acid synthase
HXV88_06655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HXV88_06660	COG0673	inositol 2-dehydrogenase activity
HXV88_06665	COG1083	cytidylyl-transferase
HXV88_06670	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_06705	COG1086	Polysaccharide biosynthesis protein
HXV88_06730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_06745	COG1091	dTDP-4-dehydrorhamnose reductase activity
HXV88_06760	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HXV88_06780	COG1136	(ABC) transporter
HXV88_06780	COG0577	efflux transmembrane transporter activity
HXV88_06785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_06790	COG1227	inorganic diphosphatase activity
HXV88_06795	COG0497	DNA recombination
HXV88_06800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HXV88_06805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HXV88_06810	COG0443	Heat shock 70 kDa protein
HXV88_06815	COG0484	heat shock protein binding
HXV88_06845	COG1285	pathogenesis
HXV88_06855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_06890	COG1566	PFAM secretion protein HlyD family protein
HXV88_06895	COG0577	efflux transmembrane transporter activity
HXV88_06895	COG1136	(ABC) transporter
HXV88_06900	COG1136	(ABC) transporter
HXV88_06900	COG0577	efflux transmembrane transporter activity
HXV88_06905	COG0577	efflux transmembrane transporter activity
HXV88_06905	COG1136	(ABC) transporter
HXV88_06915	COG0095	Lipoate-protein ligase
HXV88_06925	COG0702	epimerase
HXV88_06930	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_06935	COG1454	alcohol dehydrogenase
HXV88_06945	COG0564	pseudouridine synthase activity
HXV88_06975	COG1280	lysine exporter protein (LysE YggA)
HXV88_06990	COG3263	regulation of cellular component size
HXV88_07000	COG1876	peptidase activity
HXV88_07005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXV88_07010	COG1393	Belongs to the ArsC family
HXV88_07015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HXV88_07025	COG2003	Belongs to the UPF0758 family
HXV88_07075	COG3069	C4-dicarboxylate transmembrane transporter activity
HXV88_07080	COG1473	amidohydrolase
HXV88_07090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HXV88_07100	COG0017	Asparaginyl-tRNA synthetase
HXV88_07115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HXV88_07120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXV88_07125	COG0156	8-amino-7-oxononanoate synthase activity
HXV88_07135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HXV88_07140	COG0501	Belongs to the peptidase M48B family
HXV88_07150	COG0633	Ferredoxin
HXV88_07150	COG3217	Mosc domain protein beta barrel domain protein
HXV88_07150	COG0633	Ferredoxin
HXV88_07150	COG3217	Mosc domain protein beta barrel domain protein
HXV88_07165	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HXV88_07165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXV88_07165	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXV88_07165	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXV88_07175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HXV88_07180	COG1607	acyl-coa hydrolase
HXV88_07190	COG3021	interspecies interaction between organisms
HXV88_07195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HXV88_07200	COG2027	D-alanyl-D-alanine carboxypeptidase
HXV88_07205	COG1061	Type III restriction enzyme res subunit
HXV88_07210	COG1566	PFAM secretion protein HlyD family protein
HXV88_07220	COG1966	Carbon starvation protein
HXV88_07225	COG3279	Response regulator of the LytR AlgR family
HXV88_07230	COG3275	phosphorelay sensor kinase activity
HXV88_07235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_07235	COG2199	diguanylate cyclase activity
HXV88_07245	COG1940	carbohydrate kinase activity
HXV88_07245	COG1846	Transcriptional regulator
HXV88_07250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXV88_07255	COG0363	glucosamine-6-phosphate deaminase activity
HXV88_07260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_07260	COG1263	PTS System
HXV88_07260	COG2190	(PTS) system
HXV88_07270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_07275	COG0735	belongs to the Fur family
HXV88_07285	COG0716	FMN binding
HXV88_07300	COG0596	Alpha beta hydrolase
HXV88_07305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HXV88_07310	COG0033	Phosphoglucomutase
HXV88_07325	COG2951	lytic endotransglycosylase activity
HXV88_07330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HXV88_07335	COG4136	ATPase activity
HXV88_07345	COG4134	Bacterial extracellular solute-binding protein
HXV88_07355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HXV88_07365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_07375	COG0729	surface antigen
HXV88_07380	COG2911	Protein conserved in bacteria
HXV88_07400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HXV88_07410	COG0741	lytic transglycosylase activity
HXV88_07420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_07425	COG4771	TonB-dependent receptor
HXV88_07430	COG1169	isochorismate synthase
HXV88_07435	COG1021	2,3-dihydroxybenzoate-AMP ligase
HXV88_07440	COG1535	isochorismatase
HXV88_07440	COG3433	isochorismatase activity
HXV88_07445	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_07450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HXV88_07450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HXV88_07475	COG1278	Cold shock
HXV88_07500	COG4166	transmembrane transport
HXV88_07505	COG1349	DNA-binding transcription factor activity
HXV88_07510	COG1882	Formate acetyltransferase
HXV88_07515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_07520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HXV88_07530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_07545	COG4166	transmembrane transport
HXV88_07550	COG0622	Phosphoesterase
HXV88_07565	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HXV88_07570	COG0784	Response regulator, receiver
HXV88_07570	COG0835	chemotaxis
HXV88_07575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HXV88_07580	COG1815	bacterial-type flagellum-dependent cell motility
HXV88_07600	COG4787	bacterial-type flagellum-dependent cell motility
HXV88_07610	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HXV88_07615	COG1706	bacterial-type flagellum-dependent cell motility
HXV88_07630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_07635	COG2239	Acts as a magnesium transporter
HXV88_07645	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HXV88_07650	COG2716	regulation of RNA biosynthetic process
HXV88_07665	COG3852	Histidine kinase
HXV88_07675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HXV88_07680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HXV88_07685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HXV88_07690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HXV88_07710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HXV88_07725	COG0590	tRNA wobble adenosine to inosine editing
HXV88_07730	COG0573	inorganic phosphate transmembrane transporter activity
HXV88_07735	COG0581	inorganic phosphate transmembrane transporter activity
HXV88_07745	COG0704	Plays a role in the regulation of phosphate uptake
HXV88_07750	COG1253	flavin adenine dinucleotide binding
HXV88_07765	COG0531	amino acid
HXV88_07780	COG1126	abc transporter atp-binding protein
HXV88_07785	COG0765	amino acid transport
HXV88_07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_07795	COG2203	Gaf domain
HXV88_07795	COG2199	diguanylate cyclase activity
HXV88_07800	COG2271	Major facilitator Superfamily
HXV88_07810	COG2197	response regulator
HXV88_07815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HXV88_07835	COG1785	Belongs to the alkaline phosphatase family
HXV88_07840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HXV88_07845	COG0123	including yeast histone deacetylase and acetoin utilization protein
HXV88_07855	COG1199	ATP-dependent helicase activity
HXV88_07870	COG1605	Chorismate mutase
HXV88_07870	COG0287	Prephenate dehydrogenase
HXV88_07875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_07885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_07890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_07925	COG0537	adenosine 5'-monophosphoramidase activity
HXV88_07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HXV88_07955	COG1301	dicarboxylic acid transport
HXV88_07975	COG2354	Protein conserved in bacteria
HXV88_07985	COG2233	PERMEase
HXV88_07990	COG3150	esterase
HXV88_07995	COG1252	NADH dehydrogenase
HXV88_08005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_08010	COG3300	MHYT domain
HXV88_08010	COG5001	Diguanylate cyclase
HXV88_08015	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_08025	COG2373	Large extracellular alpha-helical protein
HXV88_08030	COG4953	penicillin-binding protein 1C
HXV88_08040	COG0301	tRNA thio-modification
HXV88_08040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_08055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_08065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HXV88_08110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_08120	COG2089	acid synthase
HXV88_08130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HXV88_08135	COG1083	cytidylyl-transferase
HXV88_08140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HXV88_08145	COG1086	Polysaccharide biosynthesis protein
HXV88_08160	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HXV88_08175	COG0483	inositol monophosphate 1-phosphatase activity
HXV88_08185	COG0625	glutathione transferase activity
HXV88_08190	COG2814	Major facilitator Superfamily
HXV88_08195	COG0583	DNA-binding transcription factor activity
HXV88_08200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HXV88_08205	COG0243	molybdopterin cofactor binding
HXV88_08225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_08230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_08235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HXV88_08240	COG0509	glycine decarboxylation via glycine cleavage system
HXV88_08245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXV88_08245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HXV88_08250	COG0840	transmembrane signaling receptor activity
HXV88_08260	COG0367	asparagine synthase
HXV88_08270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HXV88_08270	COG4651	solute:proton antiporter activity
HXV88_08275	COG0647	UMP catabolic process
HXV88_08280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXV88_08290	COG1902	pentaerythritol trinitrate reductase activity
HXV88_08295	COG1253	flavin adenine dinucleotide binding
HXV88_08305	COG0247	lactate metabolic process
HXV88_08305	COG0277	FAD linked oxidase domain protein
HXV88_08315	COG2050	protein possibly involved in aromatic compounds catabolism
HXV88_08330	COG3300	MHYT domain
HXV88_08330	COG5001	Diguanylate cyclase
HXV88_08335	COG2056	Na+-H+ antiporter family
HXV88_08340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXV88_08345	COG0671	phosphoesterase, PA-phosphatase related
HXV88_08350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXV88_08355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXV88_08365	COG0101	tRNA pseudouridine synthase activity
HXV88_08370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HXV88_08375	COG0285	dihydrofolate synthase activity
HXV88_08380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HXV88_08385	COG0393	Putative heavy-metal-binding
HXV88_08395	COG1648	precorrin-2 dehydrogenase activity
HXV88_08395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_08415	COG4667	esterase of the alpha-beta hydrolase superfamily
HXV88_08420	COG1619	proteins homologs of microcin C7 resistance protein MccF
HXV88_08425	COG1368	sulfuric ester hydrolase activity
HXV88_08435	COG0527	aspartate kinase activity
HXV88_08440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HXV88_08440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HXV88_08445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HXV88_08625	COG0596	Alpha beta hydrolase
HXV88_08645	COG1136	(ABC) transporter
HXV88_08660	COG2814	Major facilitator Superfamily
HXV88_08680	COG0672	)-iron permease
HXV88_08700	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_08720	COG3039	Transposase
HXV88_08735	COG2314	TM2 domain
HXV88_08745	COG0582	viral genome integration into host DNA
HXV88_08810	COG0659	secondary active sulfate transmembrane transporter activity
HXV88_08900	COG3501	Rhs element vgr protein
HXV88_08910	COG3209	COG3209 Rhs family protein
HXV88_08935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HXV88_08940	COG0326	Molecular chaperone. Has ATPase activity
HXV88_08945	COG4172	Belongs to the ABC transporter superfamily
HXV88_08950	COG4172	Belongs to the ABC transporter superfamily
HXV88_08960	COG4168	peptide transport system, permease
HXV88_08970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HXV88_08975	COG1842	Phage shock protein A
HXV88_08990	COG3106	COG3106 Predicted ATPase
HXV88_08995	COG3768	UPF0283 membrane protein
HXV88_09005	COG2154	pterin-4-alpha-carbinolamine dehydratase
HXV88_09025	COG2199	diguanylate cyclase activity
HXV88_09030	COG2885	chlorophyll binding
HXV88_09035	COG0861	Integral membrane protein TerC family
HXV88_09065	COG2910	NAD(P)H-binding
HXV88_09070	COG0583	DNA-binding transcription factor activity
HXV88_09075	COG0583	DNA-binding transcription factor activity
HXV88_09080	COG2271	Major facilitator Superfamily
HXV88_09090	COG1335	isochorismatase
HXV88_09105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HXV88_09115	COG0583	DNA-binding transcription factor activity
HXV88_09120	COG2723	6-phospho-beta-galactosidase activity
HXV88_09125	COG1944	ATP diphosphatase activity
HXV88_09130	COG2116	formate transmembrane transporter activity
HXV88_09135	COG1882	Formate acetyltransferase
HXV88_09140	COG2983	Belongs to the UPF0260 family
HXV88_09160	COG0058	SHG alpha-glucan phosphorylase activity
HXV88_09165	COG0471	metal ion transport
HXV88_09170	COG3118	belongs to the thioredoxin family
HXV88_09180	COG1132	(ABC) transporter
HXV88_09185	COG1132	(ABC) transporter
HXV88_09195	COG2501	S4 domain
HXV88_09210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HXV88_09265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HXV88_09270	COG1053	succinate dehydrogenase
HXV88_09280	COG0567	Dehydrogenase, E1 component
HXV88_09285	COG0508	dehydrogenase complex catalyzes the overall conversion of
HXV88_09290	COG0045	succinate-CoA ligase (ADP-forming) activity
HXV88_09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_09315	COG3842	ATPase activity
HXV88_09320	COG1840	ABC-type Fe3 transport system, periplasmic component
HXV88_09330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HXV88_09340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_09355	COG3088	subunit of a heme lyase
HXV88_09355	COG4235	cytochrome complex assembly
HXV88_09365	COG1138	Cytochrome C-type biogenesis protein
HXV88_09370	COG3301	Polysulphide reductase, NrfD
HXV88_09375	COG0437	4 iron, 4 sulfur cluster binding
HXV88_09380	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HXV88_09395	COG0247	lactate metabolic process
HXV88_09400	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HXV88_09405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HXV88_09410	COG3012	SEC-C Motif Domain Protein
HXV88_09415	COG0840	transmembrane signaling receptor activity
HXV88_09420	COG1846	Transcriptional regulator
HXV88_09420	COG1940	carbohydrate kinase activity
HXV88_09430	COG0730	response to heat
HXV88_09435	COG0583	DNA-binding transcription factor activity
HXV88_09450	COG3593	DNA synthesis involved in DNA repair
HXV88_09500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HXV88_09505	COG1011	Hydrolase
HXV88_09520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXV88_09525	COG2832	Protein of unknown function (DUF454)
HXV88_09530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HXV88_09540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HXV88_09545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HXV88_09560	COG1560	Kdo2-lipid A biosynthetic process
HXV88_09565	COG1560	Kdo2-lipid A biosynthetic process
HXV88_09580	COG2199	diguanylate cyclase activity
HXV88_09580	COG2203	Gaf domain
HXV88_09590	COG0417	DNA replication proofreading
HXV88_09605	COG1451	nucleotide metabolic process
HXV88_09620	COG3069	C4-dicarboxylate transmembrane transporter activity
HXV88_09635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_09635	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HXV88_09640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_09645	COG0569	domain protein
HXV88_09645	COG2985	domain, Protein
HXV88_09660	COG0556	nucleotide-excision repair
HXV88_09670	COG0586	Pfam SNARE associated Golgi protein
HXV88_09675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HXV88_09680	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_09695	COG4681	YaeQ
HXV88_09750	COG0307	riboflavin synthase, alpha
HXV88_09760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_09765	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HXV88_09770	COG0697	spore germination
HXV88_09775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HXV88_09815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXV88_09820	COG3099	Belongs to the UPF0263 family
HXV88_09825	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HXV88_09830	COG2894	cell division
HXV88_09835	COG0850	regulation of cytokinetic process
HXV88_09840	COG3100	YcgL domain-containing protein
HXV88_09845	COG1760	l-serine dehydratase
HXV88_09850	COG1760	l-serine dehydratase
HXV88_09855	COG3123	guanosine phosphorylase activity
HXV88_09865	COG0205	6-phosphofructokinase activity
HXV88_09875	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HXV88_09880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXV88_09890	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HXV88_09895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HXV88_09900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HXV88_09915	COG0242	peptide deformylase activity
HXV88_09945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXV88_09950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXV88_09955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HXV88_09965	COG0549	Belongs to the carbamate kinase family
HXV88_09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_09990	COG0697	spore germination
HXV88_10000	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HXV88_10000	COG3608	succinylglutamate desuccinylase aspartoacylase
HXV88_10005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HXV88_10010	COG2068	MobA-Related Protein
HXV88_10015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_10015	COG0493	'glutamate synthase
HXV88_10020	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_10025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXV88_10030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXV88_10030	COG2080	2 iron, 2 sulfur cluster binding
HXV88_10035	COG2233	PERMEase
HXV88_10040	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_10045	COG2252	PERMEase
HXV88_10050	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HXV88_10055	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HXV88_10060	COG2080	2 iron, 2 sulfur cluster binding
HXV88_10065	COG3134	Outer membrane lipoprotein
HXV88_10080	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_10085	COG3706	GGDEF domain
HXV88_10100	COG0107	imidazoleglycerol-phosphate synthase activity
HXV88_10105	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HXV88_10110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HXV88_10115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HXV88_10115	COG0131	Imidazoleglycerol-phosphate dehydratase
HXV88_10120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HXV88_10125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HXV88_10130	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HXV88_10140	COG1199	ATP-dependent helicase activity
HXV88_10145	COG1214	PFAM Peptidase M22, glycoprotease
HXV88_10155	COG2267	carboxylic ester hydrolase activity
HXV88_10160	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_10170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXV88_10175	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HXV88_10180	COG0709	Synthesizes selenophosphate from selenide and ATP
HXV88_10195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXV88_10200	COG0840	transmembrane signaling receptor activity
HXV88_10205	COG1254	Belongs to the acylphosphatase family
HXV88_10215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_10215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_10220	COG0489	protein tyrosine kinase activity
HXV88_10225	COG0572	uridine kinase
HXV88_10230	COG0717	Belongs to the dCTP deaminase family
HXV88_10235	COG0306	phosphate transporter
HXV88_10240	COG3313	Fe-S protein
HXV88_10245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HXV88_10250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_10255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXV88_10260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HXV88_10270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HXV88_10280	COG0366	Alpha amylase catalytic
HXV88_10300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HXV88_10305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HXV88_10310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HXV88_10315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HXV88_10320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HXV88_10325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_10325	COG0072	phenylalanine-tRNA ligase activity
HXV88_10330	COG0776	regulation of translation
HXV88_10335	COG2205	protein histidine kinase activity
HXV88_10335	COG0784	Response regulator, receiver
HXV88_10360	COG3300	MHYT domain
HXV88_10360	COG5001	Diguanylate cyclase
HXV88_10365	COG1609	Transcriptional regulator
HXV88_10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_10375	COG1879	ABC-type sugar transport system periplasmic component
HXV88_10380	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_10385	COG1129	ABC transporter
HXV88_10390	COG1869	D-ribose catabolic process
HXV88_10425	COG1177	transmembrane transport
HXV88_10450	COG0037	tRNA processing
HXV88_10455	COG0589	response to stress
HXV88_10460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXV88_10475	COG2217	Heavy metal translocating P-type atpase
HXV88_10485	COG2010	Cytochrome c
HXV88_10500	COG3278	Belongs to the heme-copper respiratory oxidase family
HXV88_10510	COG1956	GAF domain-containing protein
HXV88_10515	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HXV88_10525	COG0308	aminopeptidase N
HXV88_10535	COG2902	Dehydrogenase
HXV88_10540	COG0167	dihydroorotate dehydrogenase activity
HXV88_10555	COG0254	rRNA binding
HXV88_10560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HXV88_10565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HXV88_10565	COG0116	Belongs to the methyltransferase superfamily
HXV88_10585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_10590	COG1067	ATP-dependent peptidase activity
HXV88_10605	COG4128	Pfam Zonular occludens toxin
HXV88_10655	COG4128	Pfam Zonular occludens toxin
HXV88_10710	COG3141	response to X-ray
HXV88_10715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HXV88_10720	COG4221	oxidoreductase activity
HXV88_10765	COG0372	Belongs to the citrate synthase family
HXV88_10770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HXV88_10780	COG2995	paraquat-inducible protein a
HXV88_10785	COG3008	intermembrane lipid transfer
HXV88_10790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_10790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HXV88_10805	COG0084	hydrolase, TatD family'
HXV88_10810	COG0470	DNA polymerase III
HXV88_10815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HXV88_10820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HXV88_10825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HXV88_10830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_10835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXV88_10840	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_10850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HXV88_10855	COG0416	fatty acid biosynthetic process
HXV88_10860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HXV88_10865	COG1399	metal-binding, possibly nucleic acid-binding protein
HXV88_10870	COG0424	maF-like protein
HXV88_10885	COG1530	ribonuclease E activity
HXV88_10890	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HXV88_10890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_10890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_10895	COG1105	Belongs to the carbohydrate kinase PfkB family
HXV88_10900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_10900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_10905	COG1609	Transcriptional regulator
HXV88_10910	COG0814	amino acid
HXV88_10930	COG0513	Belongs to the DEAD box helicase family
HXV88_10940	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HXV88_10945	COG2890	protein-(glutamine-N5) methyltransferase activity
HXV88_10950	COG2840	Smr protein MutS2
HXV88_10955	COG3706	GGDEF domain
HXV88_10960	COG0406	alpha-ribazole phosphatase activity
HXV88_10980	COG2824	Alkylphosphonate utilization operon protein PhnA
HXV88_10995	COG0494	nUDIX hydrolase
HXV88_11000	COG0814	amino acid
HXV88_11005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HXV88_11010	COG0514	ATP-dependent DNA helicase (RecQ)
HXV88_11015	COG2766	serine protein kinase
HXV88_11020	COG2718	Belongs to the UPF0229 family
HXV88_11025	COG2719	SpoVR family
HXV88_11030	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXV88_11030	COG1024	Enoyl-CoA hydratase
HXV88_11035	COG0183	Belongs to the thiolase family
HXV88_11040	COG0714	Associated with various cellular activities
HXV88_11060	COG2304	oxidoreductase activity
HXV88_11070	COG1595	DNA-templated transcription, initiation
HXV88_11080	COG2067	long-chain fatty acid transport protein
HXV88_11085	COG2067	long-chain fatty acid transport protein
HXV88_11090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HXV88_11105	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HXV88_11115	COG1643	Atp-dependent helicase
HXV88_11120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXV88_11120	COG0517	IMP dehydrogenase activity
HXV88_11120	COG0617	tRNA 3'-terminal CCA addition
HXV88_11125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_11130	COG3119	arylsulfatase activity
HXV88_11135	COG0714	Associated with various cellular activities
HXV88_11150	COG2304	oxidoreductase activity
HXV88_11155	COG2304	oxidoreductase activity
HXV88_11185	COG0641	radical SAM
HXV88_11190	COG2925	Exonuclease
HXV88_11200	COG3345	alpha-galactosidase
HXV88_11205	COG1380	Effector of murein hydrolase LrgA
HXV88_11210	COG1346	cytolysis
HXV88_11215	COG0295	cytidine deaminase activity
HXV88_11220	COG3033	Beta-eliminating lyase
HXV88_11230	COG3046	protein related to deoxyribodipyrimidine photolyase
HXV88_11235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_11240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HXV88_11265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_11280	COG3158	transport of potassium into the cell
HXV88_11295	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_11300	COG0651	ATP synthesis coupled electron transport
HXV88_11305	COG0650	Formate hydrogenlyase subunit 4
HXV88_11310	COG3261	NADH dehydrogenase
HXV88_11310	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HXV88_11315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_11320	COG3260	NADH ubiquinone oxidoreductase 20
HXV88_11330	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HXV88_11340	COG1921	L-seryl-tRNASec selenium transferase activity
HXV88_11350	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HXV88_11355	COG0298	carbon dioxide binding
HXV88_11365	COG0309	Hydrogenase expression formation protein (HypE)
HXV88_11370	COG0375	protein maturation
HXV88_11375	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HXV88_11380	COG1124	(ABC) transporter
HXV88_11385	COG0444	Belongs to the ABC transporter superfamily
HXV88_11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_11405	COG1773	rubredoxin
HXV88_11410	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HXV88_11415	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HXV88_11420	COG5557	Pfam Polysulphide reductase, NrfD
HXV88_11425	COG0437	4 iron, 4 sulfur cluster binding
HXV88_11430	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HXV88_11435	COG5001	Diguanylate cyclase
HXV88_11435	COG4251	negative regulation of phosphorylation
HXV88_11435	COG3706	GGDEF domain
HXV88_11435	COG2203	Gaf domain
HXV88_11440	COG0438	transferase activity, transferring glycosyl groups
HXV88_11445	COG0438	transferase activity, transferring glycosyl groups
HXV88_11465	COG0438	transferase activity, transferring glycosyl groups
HXV88_11495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HXV88_11510	COG0438	transferase activity, transferring glycosyl groups
HXV88_11515	COG1215	transferase activity, transferring glycosyl groups
HXV88_11520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_11560	COG2205	protein histidine kinase activity
HXV88_11560	COG0784	Response regulator, receiver
HXV88_11595	COG0730	response to heat
HXV88_11605	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_11615	COG1024	Enoyl-CoA hydratase
HXV88_11620	COG1024	Enoyl-CoA hydratase
HXV88_11625	COG1960	acyl-CoA dehydrogenase activity
HXV88_11630	COG1960	acyl-CoA dehydrogenase activity
HXV88_11635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HXV88_11640	COG1024	Enoyl-CoA hydratase
HXV88_11670	COG1584	GPR1 FUN34 yaaH family protein
HXV88_11675	COG4974	Belongs to the 'phage' integrase family
HXV88_11760	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_11765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HXV88_11775	COG1073	alpha beta
HXV88_11780	COG0583	DNA-binding transcription factor activity
HXV88_11785	COG1073	alpha beta
HXV88_11800	COG1115	amino acid carrier protein
HXV88_11830	COG4695	Portal protein
HXV88_11835	COG1024	Enoyl-CoA hydratase
HXV88_11850	COG3162	membrane
HXV88_11855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXV88_12015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HXV88_12020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_12085	COG2319	Wd-40 repeat
HXV88_12085	COG1672	PFAM Archaeal ATPase
HXV88_12170	COG0582	viral genome integration into host DNA
HXV88_12175	COG0488	(ABC) transporter
HXV88_12180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HXV88_12185	COG0776	regulation of translation
HXV88_12190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HXV88_12195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HXV88_12200	COG0740	serine-type endopeptidase activity
HXV88_12205	COG0544	peptidyl-prolyl cis-trans isomerase activity
HXV88_12215	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HXV88_12220	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXV88_12225	COG1136	(ABC) transporter
HXV88_12230	COG4591	ABC-type transport system involved in lipoprotein release permease component
HXV88_12240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HXV88_12245	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HXV88_12255	COG0697	spore germination
HXV88_12265	COG2062	phosphohistidine phosphatase, SixA
HXV88_12270	COG1025	Belongs to the peptidase M16 family
HXV88_12305	COG0519	Catalyzes the synthesis of GMP from XMP
HXV88_12305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXV88_12310	COG0517	IMP dehydrogenase activity
HXV88_12310	COG0516	GMP reductase activity
HXV88_12315	COG3038	cytochrome b561
HXV88_12320	COG1570	exodeoxyribonuclease VII activity
HXV88_12325	COG2188	Transcriptional regulator
HXV88_12330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_12330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_12330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_12335	COG0383	alpha-mannosidase activity
HXV88_12340	COG1181	Belongs to the D-alanine--D-alanine ligase family
HXV88_12350	COG0386	Belongs to the glutathione peroxidase family
HXV88_12355	COG0513	Belongs to the DEAD box helicase family
HXV88_12370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_12375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HXV88_12380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HXV88_12430	COG3300	MHYT domain
HXV88_12430	COG5001	Diguanylate cyclase
HXV88_12445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_12455	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HXV88_12460	COG0563	adenylate kinase activity
HXV88_12470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HXV88_12475	COG1286	toxin biosynthetic process
HXV88_12485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HXV88_12490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HXV88_12495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HXV88_12500	COG0531	amino acid
HXV88_12500	COG1674	ftsk spoiiie
HXV88_12510	COG0686	Belongs to the AlaDH PNT family
HXV88_12515	COG0492	ferredoxin-NADP+ reductase activity
HXV88_12520	COG3706	GGDEF domain
HXV88_12525	COG3134	Outer membrane lipoprotein
HXV88_12530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HXV88_12535	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HXV88_12540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HXV88_12545	COG0542	response to heat
HXV88_12550	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HXV88_12555	COG1278	Cold shock
HXV88_12560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HXV88_12580	COG0745	RESPONSE REGULATOR receiver
HXV88_12585	COG2205	protein histidine kinase activity
HXV88_12595	COG0392	lysyltransferase activity
HXV88_12595	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HXV88_12620	COG1435	thymidine kinase activity
HXV88_12625	COG1757	Na H antiporter
HXV88_12630	COG2916	Histone family protein nucleoid-structuring protein H-NS
HXV88_12635	COG2096	Adenosyltransferase
HXV88_12640	COG3530	Putative quorum-sensing-regulated virulence factor
HXV88_12645	COG0602	queuosine metabolic process
HXV88_12650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HXV88_12670	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HXV88_12680	COG0776	regulation of translation
HXV88_12685	COG0539	negative regulation of cytoplasmic translation
HXV88_12690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HXV88_12695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXV88_12710	COG2814	Major facilitator Superfamily
HXV88_12730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HXV88_12735	COG5001	Diguanylate cyclase
HXV88_12735	COG3300	MHYT domain
HXV88_12740	COG0583	DNA-binding transcription factor activity
HXV88_12745	COG3437	response regulator, receiver
HXV88_12770	COG4989	oxidoreductase activity
HXV88_12775	COG0724	RNA recognition motif
HXV88_12785	COG1126	abc transporter atp-binding protein
HXV88_12790	COG0765	amino acid transport
HXV88_12800	COG4597	amino acid ABC transporter
HXV88_12805	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HXV88_12815	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HXV88_12830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_12835	COG1360	Flagellar Motor Protein
HXV88_12840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_12845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_12850	COG0649	NAD binding
HXV88_12850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_12865	COG1034	ATP synthesis coupled electron transport
HXV88_12870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HXV88_12875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_12880	COG0839	Belongs to the complex I subunit 6 family
HXV88_12885	COG0713	ATP synthesis coupled electron transport
HXV88_12895	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_12900	COG1007	ATP synthesis coupled electron transport
HXV88_12915	COG2199	diguanylate cyclase activity
HXV88_12915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_12920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HXV88_12920	COG0047	phosphoribosylformylglycinamidine synthase activity
HXV88_12925	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HXV88_12930	COG1645	bacterial-type flagellum-dependent swarming motility
HXV88_12935	COG1160	GTP binding
HXV88_12940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_12945	COG2976	Protein conserved in bacteria
HXV88_12950	COG0124	histidyl-tRNA synthetase
HXV88_12970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HXV88_12975	COG0105	UTP biosynthetic process
HXV88_12990	COG0633	Ferredoxin
HXV88_12995	COG0443	Heat shock 70 kDa protein
HXV88_13000	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HXV88_13010	COG0822	iron-sulfur transferase activity
HXV88_13015	COG1104	cysteine desulfurase activity
HXV88_13035	COG3154	lipid carrier protein
HXV88_13040	COG0826	peptidase U32
HXV88_13045	COG0826	peptidase U32
HXV88_13060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_13065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HXV88_13070	COG1862	Preprotein translocase
HXV88_13075	COG0343	queuine tRNA-ribosyltransferase activity
HXV88_13080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HXV88_13085	COG0517	IMP dehydrogenase activity
HXV88_13095	COG3634	alkyl hydroperoxide reductase activity
HXV88_13140	COG1242	4 iron, 4 sulfur cluster binding
HXV88_13145	COG0070	glutamate synthase
HXV88_13145	COG0069	glutamate synthase activity
HXV88_13145	COG0067	glutamate synthase
HXV88_13150	COG0493	'glutamate synthase
HXV88_13160	COG0513	Belongs to the DEAD box helicase family
HXV88_13185	COG0023	Translation Initiation Factor
HXV88_13190	COG2119	membrane
HXV88_13240	COG0215	cysteine-tRNA ligase activity
HXV88_13245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HXV88_13255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HXV88_13265	COG2261	transglycosylase associated protein
HXV88_13270	COG0642	Histidine kinase
HXV88_13295	COG0625	glutathione transferase activity
HXV88_13305	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HXV88_13320	COG0564	pseudouridine synthase activity
HXV88_13325	COG4160	amino acid transport
HXV88_13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_13345	COG2431	L-lysine efflux transmembrane transporter activity
HXV88_13350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HXV88_13355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_13360	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HXV88_13370	COG1393	Belongs to the ArsC family
HXV88_13380	COG4783	chaperone-mediated protein folding
HXV88_13410	COG3842	ATPase activity
HXV88_13415	COG3833	ABC-type maltose transport systems, permease component
HXV88_13420	COG1175	transmembrane transport
HXV88_13430	COG3081	Nucleoid-associated protein
HXV88_13435	COG3082	Protein of unknown function (DUF1414)
HXV88_13440	COG3083	sulfuric ester hydrolase activity
HXV88_13445	COG1464	Belongs to the NlpA lipoprotein family
HXV88_13460	COG0574	Belongs to the PEP-utilizing enzyme family
HXV88_13460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXV88_13465	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HXV88_13540	COG0322	excinuclease ABC activity
HXV88_13545	COG2197	response regulator
HXV88_13550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXV88_13555	COG2835	tetraacyldisaccharide 4'-kinase activity
HXV88_13560	COG1663	tetraacyldisaccharide 4'-kinase activity
HXV88_13570	COG2333	competence protein COMEC
HXV88_13570	COG0658	competence protein
HXV88_13585	COG1448	Aminotransferase
HXV88_13595	COG0583	DNA-binding transcription factor activity
HXV88_13600	COG3085	chromosome segregation
HXV88_13605	COG4574	serine-type endopeptidase inhibitor activity
HXV88_13610	COG0584	glycerophosphoryl diester phosphodiesterase
HXV88_13620	COG1349	DNA-binding transcription factor activity
HXV88_13625	COG2271	Major facilitator Superfamily
HXV88_13630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXV88_13635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HXV88_13640	COG0840	transmembrane signaling receptor activity
HXV88_13650	COG0583	DNA-binding transcription factor activity
HXV88_13670	COG0656	L-ascorbic acid biosynthetic process
HXV88_13680	COG2814	Major facilitator Superfamily
HXV88_13685	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXV88_13700	COG3220	belongs to the UPF0276 family
HXV88_13720	COG1294	oxidase, subunit
HXV88_13730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_13740	COG2979	Protein of unknown function (DUF533)
HXV88_13755	COG0583	DNA-binding transcription factor activity
HXV88_13760	COG2807	transmembrane transport
HXV88_13765	COG1187	pseudouridine synthase activity
HXV88_13775	COG0346	lactoylglutathione lyase activity
HXV88_13785	COG1403	HNH endonuclease
HXV88_13790	COG4657	Part of a membrane complex involved in electron transport
HXV88_13795	COG2878	Part of a membrane complex involved in electron transport
HXV88_13805	COG4658	electron transport chain
HXV88_13810	COG4659	FMN binding
HXV88_13815	COG4660	Part of a membrane complex involved in electron transport
HXV88_13820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HXV88_13825	COG0346	lactoylglutathione lyase activity
HXV88_13865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HXV88_13870	COG0505	Belongs to the CarA family
HXV88_13875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HXV88_13890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HXV88_13895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HXV88_13900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HXV88_13905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HXV88_13910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HXV88_13920	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HXV88_13950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXV88_13955	COG0861	Integral membrane protein TerC family
HXV88_13970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_13975	COG0601	transmembrane transport
HXV88_13985	COG2095	MarC family integral membrane protein
HXV88_13990	COG1454	alcohol dehydrogenase
HXV88_13990	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_13995	COG0217	transcriptional regulatory protein
HXV88_14000	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HXV88_14010	COG1801	Protein of unknown function DUF72
HXV88_14015	COG4106	trans-aconitate 2-methyltransferase activity
HXV88_14020	COG0500	methyltransferase
HXV88_14040	COG0450	alkyl hydroperoxide reductase
HXV88_14045	COG0583	DNA-binding transcription factor activity
HXV88_14050	COG0791	NLP P60 protein
HXV88_14060	COG0583	DNA-binding transcription factor activity
HXV88_14065	COG2610	gluconate transmembrane transporter activity
HXV88_14070	COG3048	D-serine ammonia-lyase activity
HXV88_14080	COG0538	isocitrate dehydrogenase activity
HXV88_14085	COG2207	Transcriptional regulator
HXV88_14090	COG1482	cell wall glycoprotein biosynthetic process
HXV88_14095	COG0840	transmembrane signaling receptor activity
HXV88_14100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_14115	COG3152	Membrane
HXV88_14150	COG1309	transcriptional regulator
HXV88_14180	COG0534	Mate efflux family protein
HXV88_14190	COG2841	Protein conserved in bacteria
HXV88_14200	COG5001	Diguanylate cyclase
HXV88_14200	COG3300	MHYT domain
HXV88_14205	COG3132	Protein of unknown function, DUF480
HXV88_14235	COG0708	Exodeoxyribonuclease III
HXV88_14270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_14275	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_14290	COG1120	ATPase activity
HXV88_14295	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_14300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_14305	COG2375	cellular response to nickel ion
HXV88_14310	COG0784	Response regulator, receiver
HXV88_14310	COG3437	response regulator, receiver
HXV88_14320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HXV88_14325	COG0328	RNA-DNA hybrid ribonuclease activity
HXV88_14330	COG2226	methyltransferase
HXV88_14335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HXV88_14340	COG0741	lytic transglycosylase activity
HXV88_14340	COG1388	LysM domain
HXV88_14365	COG5000	phosphorelay sensor kinase activity
HXV88_14365	COG5002	protein histidine kinase activity
HXV88_14370	COG0745	RESPONSE REGULATOR receiver
HXV88_14375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HXV88_14380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_14405	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HXV88_14410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HXV88_14465	COG1376	ErfK ybiS ycfS ynhG family protein
HXV88_14465	COG1388	LysM domain
HXV88_14475	COG0471	metal ion transport
HXV88_14485	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HXV88_14490	COG0791	NLP P60 protein
HXV88_14500	COG3118	belongs to the thioredoxin family
HXV88_14510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HXV88_14515	COG0788	formyltetrahydrofolate deformylase activity
HXV88_14525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_14540	COG0739	heme binding
HXV88_14540	COG1196	nuclear chromosome segregation
HXV88_14540	COG0741	lytic transglycosylase activity
HXV88_14545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HXV88_14555	COG0436	Aminotransferase
HXV88_14560	COG1288	antiporter activity
HXV88_14565	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HXV88_14580	COG2964	Protein conserved in bacteria
HXV88_14585	COG3681	Belongs to the UPF0597 family
HXV88_14595	COG0814	amino acid
HXV88_14615	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HXV88_14625	COG1166	arginine decarboxylase activity
HXV88_14630	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_14645	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HXV88_14655	COG2353	YceI-like domain
HXV88_14660	COG0583	DNA-binding transcription factor activity
HXV88_14670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HXV88_14675	COG0840	transmembrane signaling receptor activity
HXV88_14680	COG0302	gtp cyclohydrolase
HXV88_14690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXV88_14710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HXV88_14725	COG0314	molybdopterin synthase activity
HXV88_14730	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HXV88_14735	COG0315	cyclic pyranopterin monophosphate synthase activity
HXV88_14740	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXV88_14745	COG3005	denitrification pathway
HXV88_14755	COG0348	domain, Protein
HXV88_14760	COG0437	4 iron, 4 sulfur cluster binding
HXV88_14765	COG0243	molybdopterin cofactor binding
HXV88_14775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_14780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HXV88_14785	COG3850	Histidine kinase
HXV88_14790	COG2197	response regulator
HXV88_14820	COG0121	glutamine amidotransferase
HXV88_14825	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HXV88_14830	COG1960	acyl-CoA dehydrogenase activity
HXV88_14835	COG1473	amidohydrolase
HXV88_14840	COG2914	Belongs to the UPF0125 (RnfH) family
HXV88_14845	COG2867	negative regulation of translational initiation
HXV88_14850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HXV88_14860	COG2205	protein histidine kinase activity
HXV88_14860	COG0784	Response regulator, receiver
HXV88_14870	COG3383	formate dehydrogenase (NAD+) activity
HXV88_14910	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_14915	COG1172	Belongs to the binding-protein-dependent transport system permease family
HXV88_14920	COG1129	ABC transporter
HXV88_14930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HXV88_14955	COG1061	Type III restriction enzyme res subunit
HXV88_14965	COG2003	Belongs to the UPF0758 family
HXV88_15005	COG5377	YqaJ viral recombinase family
HXV88_15110	COG0785	Cytochrome C biogenesis protein
HXV88_15155	COG0753	catalase activity
HXV88_15165	COG0641	radical SAM
HXV88_15170	COG3119	arylsulfatase activity
HXV88_15195	COG3311	Transcriptional regulator
HXV88_15200	COG4983	Phage plasmid primase, P4 family domain protein
HXV88_15240	COG2003	Belongs to the UPF0758 family
HXV88_15275	COG2003	Belongs to the UPF0758 family
HXV88_15300	COG1203	CRISPR-associated helicase, Cas3
HXV88_15305	COG1518	maintenance of DNA repeat elements
HXV88_15335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HXV88_15345	COG1960	acyl-CoA dehydrogenase activity
HXV88_15350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HXV88_15360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HXV88_15365	COG1317	bacterial-type flagellum organization
HXV88_15530	COG4790	Type iii secretion
HXV88_15535	COG4794	Type iii secretion
HXV88_15540	COG4791	protein targeting
HXV88_15545	COG4792	protein secretion
HXV88_15570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXV88_15575	COG1263	PTS System
HXV88_15575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HXV88_15580	COG1609	Transcriptional regulator
HXV88_15590	COG0789	Transcriptional regulator
HXV88_15605	COG0783	Belongs to the Dps family
HXV88_15630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_15630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_15630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_15635	COG2271	Major facilitator Superfamily
HXV88_15640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HXV88_15650	COG1187	pseudouridine synthase activity
HXV88_15660	COG0482	sulfurtransferase activity
HXV88_15665	COG2915	High frequency lysogenization protein hflD homolog
HXV88_15670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HXV88_15675	COG2850	peptidyl-arginine hydroxylation
HXV88_15695	COG0625	glutathione transferase activity
HXV88_15700	COG0259	pyridoxamine-phosphate oxidase activity
HXV88_15705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_15705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_15710	COG0251	oxidation-reduction process
HXV88_15715	COG1882	Formate acetyltransferase
HXV88_15720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HXV88_15730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HXV88_15735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HXV88_15755	COG4235	cytochrome complex assembly
HXV88_15755	COG3088	subunit of a heme lyase
HXV88_15760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HXV88_15765	COG1138	Cytochrome C-type biogenesis protein
HXV88_15770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HXV88_15775	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_15780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_15785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HXV88_15800	COG0835	chemotaxis
HXV88_15810	COG1192	Involved in chromosome partitioning
HXV88_15815	COG1360	Flagellar Motor Protein
HXV88_15820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HXV88_15830	COG0643	Histidine kinase
HXV88_15830	COG0784	Response regulator, receiver
HXV88_15830	COG2198	Histidine kinase
HXV88_15835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HXV88_15860	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HXV88_15870	COG1684	flagellar biosynthetic protein fliR
HXV88_15875	COG1987	bacterial-type flagellum assembly
HXV88_15925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HXV88_15935	COG1677	Flagellar hook-basal body complex protein FliE
HXV88_15955	COG0469	pyruvate kinase activity
HXV88_15960	COG1737	Transcriptional regulator
HXV88_15965	COG0837	glucose binding
HXV88_15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_16015	COG0281	malic enzyme
HXV88_16035	COG0437	4 iron, 4 sulfur cluster binding
HXV88_16040	COG3383	formate dehydrogenase (NAD+) activity
HXV88_16040	COG3383	formate dehydrogenase (NAD+) activity
HXV88_16075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HXV88_16085	COG3852	Histidine kinase
HXV88_16100	COG4662	Binding-protein-dependent transport system inner membrane component
HXV88_16110	COG0746	molybdenum cofactor guanylyltransferase activity
HXV88_16115	COG0303	'Molybdopterin
HXV88_16120	COG1289	transmembrane transporter activity
HXV88_16125	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HXV88_16155	COG3220	belongs to the UPF0276 family
HXV88_16185	COG2205	protein histidine kinase activity
HXV88_16185	COG0784	Response regulator, receiver
HXV88_16200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HXV88_16205	COG0444	Belongs to the ABC transporter superfamily
HXV88_16210	COG4608	Belongs to the ABC transporter superfamily
HXV88_16220	COG2971	BadF BadG BcrA BcrD
HXV88_16230	COG0840	transmembrane signaling receptor activity
HXV88_16250	COG3724	N-succinylarginine dihydrolase activity
HXV88_16280	COG2197	response regulator
HXV88_16305	COG2199	diguanylate cyclase activity
HXV88_16305	COG2200	EAL domain
HXV88_16305	COG2203	Gaf domain
HXV88_16315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HXV88_16320	COG1422	Protein of unknown function (DUF1090)
HXV88_16325	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HXV88_16330	COG3706	GGDEF domain
HXV88_16335	COG2211	Major facilitator Superfamily
HXV88_16340	COG0616	signal peptide processing
HXV88_16345	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_16350	COG0583	DNA-binding transcription factor activity
HXV88_16360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HXV88_16380	COG1881	PFAM PEBP family protein
HXV88_16395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HXV88_16410	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HXV88_16415	COG2912	Transglutaminase-like superfamily
HXV88_16425	COG2890	protein-(glutamine-N5) methyltransferase activity
HXV88_16430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HXV88_16435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HXV88_16440	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HXV88_16445	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HXV88_16455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HXV88_16460	COG0737	Belongs to the 5'-nucleotidase family
HXV88_16465	COG0193	aminoacyl-tRNA hydrolase activity
HXV88_16470	COG0012	GTP binding
HXV88_16515	COG0490	domain, Protein
HXV88_16515	COG0471	metal ion transport
HXV88_16525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HXV88_16545	COG0366	Alpha amylase catalytic
HXV88_16550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HXV88_16550	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HXV88_16550	COG0674	pyruvate-flavodoxin oxidoreductase activity
HXV88_16550	COG1013	pyruvate-flavodoxin oxidoreductase activity
HXV88_16560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_16575	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_16585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HXV88_16590	COG0512	Glutamine amidotransferase of anthranilate synthase
HXV88_16600	COG0180	Tryptophanyl-tRNA synthetase
HXV88_16610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HXV88_16615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HXV88_16625	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HXV88_16630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HXV88_16660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HXV88_16665	COG0583	DNA-binding transcription factor activity
HXV88_16685	COG0583	DNA-binding transcription factor activity
HXV88_16695	COG0739	heme binding
HXV88_16705	COG3264	Mechanosensitive ion channel
HXV88_16705	COG1511	domain protein
HXV88_16710	COG0584	glycerophosphoryl diester phosphodiesterase
HXV88_16720	COG1053	succinate dehydrogenase
HXV88_16725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HXV88_16730	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HXV88_16735	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HXV88_16740	COG3366	ferrous iron transmembrane transporter activity
HXV88_16745	COG0700	Nucleoside recognition
HXV88_16750	COG2195	Cleaves the N-terminal amino acid of tripeptides
HXV88_16760	COG3214	Protein conserved in bacteria
HXV88_16775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_16780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_16800	COG1022	Amp-dependent synthetase and ligase
HXV88_16810	COG4221	oxidoreductase activity
HXV88_16825	COG0642	Histidine kinase
HXV88_16835	COG0516	GMP reductase activity
HXV88_16845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HXV88_16855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HXV88_16865	COG3447	MASE1 domain protein
HXV88_16865	COG5001	Diguanylate cyclase
HXV88_16865	COG5002	protein histidine kinase activity
HXV88_16885	COG0583	DNA-binding transcription factor activity
HXV88_16890	COG3706	GGDEF domain
HXV88_16900	COG1335	isochorismatase
HXV88_16905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HXV88_16910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HXV88_16915	COG1702	phosphate starvation-inducible protein PhoH
HXV88_16920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HXV88_16925	COG4535	Mg2 and Co2 transporter CorC
HXV88_16930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HXV88_16935	COG0789	Transcriptional regulator
HXV88_16950	COG1970	mechanosensitive ion channel activity
HXV88_16955	COG4974	Belongs to the 'phage' integrase family
HXV88_16960	COG0716	FMN binding
HXV88_16965	COG0312	modulator of DNA gyrase
HXV88_16970	COG0312	modulator of DNA gyrase
HXV88_16975	COG2888	peptidyl-tyrosine sulfation
HXV88_16980	COG0495	leucyl-tRNA aminoacylation
HXV88_16995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HXV88_17000	COG0799	negative regulation of ribosome biogenesis
HXV88_17005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HXV88_17010	COG0768	penicillin binding
HXV88_17015	COG0772	Belongs to the SEDS family
HXV88_17020	COG2951	lytic endotransglycosylase activity
HXV88_17025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HXV88_17030	COG1686	Belongs to the peptidase S11 family
HXV88_17035	COG2921	Belongs to the UPF0250 family
HXV88_17040	COG0321	lipoyl(octanoyl) transferase activity
HXV88_17045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HXV88_17065	COG3139	Protein of unknown function (DUF1315)
HXV88_17070	COG0252	asparaginase activity
HXV88_17075	COG0786	glutamate:sodium symporter activity
HXV88_17090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HXV88_17095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXV88_17100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HXV88_17115	COG3610	response to peptide
HXV88_17120	COG2966	Psort location CytoplasmicMembrane, score
HXV88_17130	COG0521	Mo-molybdopterin cofactor biosynthetic process
HXV88_17145	COG2897	thiosulfate sulfurtransferase activity
HXV88_17150	COG2066	Belongs to the glutaminase family
HXV88_17155	COG3171	Protein conserved in bacteria
HXV88_17160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HXV88_17165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_17170	COG2200	EAL domain
HXV88_17175	COG1090	epimerase
HXV88_17180	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HXV88_17185	COG4181	ATPase activity
HXV88_17190	COG2755	lipolytic protein G-D-S-L family
HXV88_17195	COG0835	chemotaxis
HXV88_17195	COG0784	Response regulator, receiver
HXV88_17235	COG3397	chitin binding
HXV88_17250	COG3706	GGDEF domain
HXV88_17260	COG2205	protein histidine kinase activity
HXV88_17260	COG0784	Response regulator, receiver
HXV88_17260	COG5002	protein histidine kinase activity
HXV88_17270	COG3655	Transcriptional regulator
HXV88_17280	COG2814	Major facilitator Superfamily
HXV88_17300	COG3501	Rhs element vgr protein
HXV88_17335	COG0748	coenzyme F420 binding
HXV88_17340	COG3721	Heme iron utilization protein
HXV88_17350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_17375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HXV88_17390	COG0737	Belongs to the 5'-nucleotidase family
HXV88_17410	COG2204	response regulator
HXV88_17415	COG0545	Peptidyl-prolyl cis-trans isomerase
HXV88_17425	COG2900	Belongs to the SlyX family
HXV88_17430	COG1047	Peptidyl-prolyl cis-trans
HXV88_17435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HXV88_17445	COG0784	Response regulator, receiver
HXV88_17445	COG0835	chemotaxis
HXV88_17450	COG0429	hydrolase of the alpha beta-hydrolase fold
HXV88_17455	COG3706	GGDEF domain
HXV88_17455	COG2203	Gaf domain
HXV88_17455	COG4251	negative regulation of phosphorylation
HXV88_17455	COG5001	Diguanylate cyclase
HXV88_17460	COG3089	Belongs to the UPF0270 family
HXV88_17465	COG3954	Phosphoribulokinase
HXV88_17480	COG1765	OsmC-like protein
HXV88_17520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_17525	COG2313	pseudouridylate synthase activity
HXV88_17560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HXV88_17570	COG0318	PFAM AMP-dependent synthetase and ligase
HXV88_17575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_17585	COG2986	histidine ammonia-lyase
HXV88_17610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_17615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HXV88_17620	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_17625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HXV88_17635	COG0778	Nitroreductase
HXV88_17640	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_17640	COG1902	pentaerythritol trinitrate reductase activity
HXV88_17645	COG0616	signal peptide processing
HXV88_17665	COG0848	biopolymer transport protein
HXV88_17670	COG0811	peptide transport
HXV88_17675	COG0811	peptide transport
HXV88_17690	COG4174	ABC transporter (Permease)
HXV88_17695	COG4239	(ABC) transporter, permease
HXV88_17705	COG0444	Belongs to the ABC transporter superfamily
HXV88_17710	COG4608	Belongs to the ABC transporter superfamily
HXV88_17730	COG3416	Protein conserved in bacteria
HXV88_17740	COG0741	lytic transglycosylase activity
HXV88_17755	COG0488	(ABC) transporter
HXV88_17765	COG2252	PERMEase
HXV88_17770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_17775	COG0840	transmembrane signaling receptor activity
HXV88_17785	COG1278	Cold shock
HXV88_17825	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HXV88_17830	COG1162	GTPase activity
HXV88_17835	COG0688	phosphatidylethanolamine metabolic process
HXV88_17840	COG4628	conserved protein (DUF2132)
HXV88_17860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HXV88_17865	COG1381	Involved in DNA repair and RecF pathway recombination
HXV88_17880	COG0681	Belongs to the peptidase S26 family
HXV88_17885	COG0481	GTPase activity
HXV88_17895	COG3026	antisigma factor binding
HXV88_17900	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HXV88_17905	COG1595	DNA-templated transcription, initiation
HXV88_17910	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HXV88_17920	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HXV88_17925	COG0354	folic acid binding
HXV88_17970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HXV88_17975	COG0191	fructose-bisphosphate aldolase activity
HXV88_17980	COG0126	phosphoglycerate kinase activity
HXV88_17985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXV88_17990	COG1940	carbohydrate kinase activity
HXV88_17995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HXV88_18000	COG2816	NAD+ diphosphatase activity
HXV88_18010	COG4991	sh3 domain protein
HXV88_18015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HXV88_18030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HXV88_18065	COG2816	NAD+ diphosphatase activity
HXV88_18110	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HXV88_18120	COG2199	diguanylate cyclase activity
HXV88_18120	COG2203	Gaf domain
HXV88_18125	COG0513	Belongs to the DEAD box helicase family
HXV88_18155	COG0154	amidase activity
HXV88_18160	COG2957	Belongs to the agmatine deiminase family
HXV88_18175	COG1902	pentaerythritol trinitrate reductase activity
HXV88_18190	COG1238	metal cluster binding
HXV88_18195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HXV88_18200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HXV88_18205	COG0585	pseudouridine synthase activity
HXV88_18215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HXV88_18220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HXV88_18225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HXV88_18235	COG1376	ErfK ybiS ycfS ynhG family protein
HXV88_18240	COG0668	transmembrane transport
HXV88_18250	COG2731	YhcH YjgK YiaL family protein
HXV88_18260	COG1794	racemase activity, acting on amino acids and derivatives
HXV88_18275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HXV88_18290	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HXV88_18290	COG0617	tRNA 3'-terminal CCA addition
HXV88_18290	COG0517	IMP dehydrogenase activity
HXV88_18330	COG0488	(ABC) transporter
HXV88_18340	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HXV88_18385	COG0148	phosphopyruvate hydratase activity
HXV88_18390	COG0504	CTP synthase activity
HXV88_18395	COG3956	TIGRFAM MazG family protein
HXV88_18400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HXV88_18405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_18415	COG4807	Protein conserved in bacteria
HXV88_18420	COG3023	N-Acetylmuramoyl-L-alanine amidase
HXV88_18425	COG0783	Belongs to the Dps family
HXV88_18430	COG1151	hydroxylamine reductase activity
HXV88_18435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_18440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HXV88_18445	COG0671	phosphoesterase, PA-phosphatase related
HXV88_18450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HXV88_18455	COG0163	prenyltransferase activity
HXV88_18470	COG1131	(ABC) transporter
HXV88_18475	COG0842	Transport permease protein
HXV88_18505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HXV88_18510	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HXV88_18515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HXV88_18525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HXV88_18530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HXV88_18535	COG1489	DNA binding
HXV88_18545	COG1643	Atp-dependent helicase
HXV88_18550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HXV88_18555	COG0346	lactoylglutathione lyase activity
HXV88_18560	COG2076	Multidrug Resistance protein
HXV88_18565	COG2076	Multidrug Resistance protein
HXV88_18575	COG0784	Response regulator, receiver
HXV88_18575	COG3437	response regulator, receiver
HXV88_18580	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HXV88_18595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HXV88_18610	COG1136	(ABC) transporter
HXV88_18630	COG0840	transmembrane signaling receptor activity
HXV88_18640	COG0529	Catalyzes the synthesis of activated sulfate
HXV88_18645	COG0471	metal ion transport
HXV88_18645	COG3273	potassium ion transport
HXV88_18650	COG2895	sulfate adenylyltransferase (ATP) activity
HXV88_18655	COG0175	sulfate reduction
HXV88_18660	COG1648	precorrin-2 dehydrogenase activity
HXV88_18660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HXV88_18665	COG0330	HflC and HflK could
HXV88_18670	COG1585	Membrane protein implicated in regulation of membrane protease activity
HXV88_18675	COG0840	transmembrane signaling receptor activity
HXV88_18680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HXV88_18685	COG0676	glucose-6-phosphate 1-epimerase activity
HXV88_18690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HXV88_18695	COG1640	4-alpha-glucanotransferase
HXV88_18700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HXV88_18750	COG0561	phosphatase activity
HXV88_18765	COG0733	neurotransmitter:sodium symporter activity
HXV88_18775	COG0733	neurotransmitter:sodium symporter activity
HXV88_18840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HXV88_18845	COG2885	chlorophyll binding
HXV88_18850	COG0823	Involved in the tonB-independent uptake of proteins
HXV88_18865	COG0811	peptide transport
HXV88_18870	COG0824	Thioesterase
HXV88_18875	COG3790	cyd operon protein YbgE
HXV88_18880	COG4890	Cyd operon protein YbgT
HXV88_18885	COG1294	oxidase, subunit
HXV88_18895	COG2255	four-way junction helicase activity
HXV88_18900	COG0632	four-way junction helicase activity
HXV88_18905	COG0840	transmembrane signaling receptor activity
HXV88_18930	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HXV88_18935	COG4251	negative regulation of phosphorylation
HXV88_18935	COG3706	GGDEF domain
HXV88_18935	COG2203	Gaf domain
HXV88_18935	COG5001	Diguanylate cyclase
HXV88_18945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HXV88_18955	COG2995	paraquat-inducible protein a
HXV88_18960	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HXV88_18960	COG3008	intermembrane lipid transfer
HXV88_18965	COG3009	Protein conserved in bacteria
HXV88_18970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HXV88_18975	COG0442	prolyl-tRNA aminoacylation
HXV88_18980	COG4221	oxidoreductase activity
HXV88_18995	COG1024	Enoyl-CoA hydratase
HXV88_19005	COG0110	maltose O-acetyltransferase activity
HXV88_19015	COG4166	transmembrane transport
HXV88_19025	COG0840	transmembrane signaling receptor activity
HXV88_19050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HXV88_19050	COG1017	nitric oxide dioxygenase activity
HXV88_19055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HXV88_19060	COG0039	L-malate dehydrogenase activity
HXV88_19065	COG4160	amino acid transport
HXV88_19070	COG4215	(ABC) transporter
HXV88_19075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_19080	COG1126	abc transporter atp-binding protein
HXV88_19085	COG1438	arginine binding
HXV88_19090	COG2837	iron assimilation
HXV88_19095	COG3842	ATPase activity
HXV88_19105	COG1840	ABC-type Fe3 transport system, periplasmic component
HXV88_19110	COG0347	Belongs to the P(II) protein family
HXV88_19130	COG3022	response to hydroperoxide
HXV88_19145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HXV88_19150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HXV88_19155	COG0762	integral membrane protein
HXV88_19160	COG1872	DUF167
HXV88_19170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HXV88_19175	COG0583	DNA-binding transcription factor activity
HXV88_19195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HXV88_19200	COG0735	belongs to the Fur family
HXV88_19225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HXV88_19230	COG0513	Belongs to the DEAD box helicase family
HXV88_19235	COG2153	protein acetylation
HXV88_19245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HXV88_19250	COG0557	exoribonuclease II activity
HXV88_19255	COG3706	GGDEF domain
HXV88_19260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HXV88_19260	COG2885	chlorophyll binding
HXV88_19265	COG3240	lipase activity
HXV88_19270	COG3111	PFAM Bacterial OB fold (BOF) protein
HXV88_19280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HXV88_19285	COG1194	a g-specific adenine glycosylase
HXV88_19290	COG0617	tRNA 3'-terminal CCA addition
HXV88_19310	COG1929	Belongs to the glycerate kinase type-1 family
HXV88_19315	COG2610	gluconate transmembrane transporter activity
HXV88_19320	COG3835	regulator
HXV88_19325	COG3112	Uncharacterised protein family (UPF0231)
HXV88_19355	COG0513	Belongs to the DEAD box helicase family
HXV88_19395	COG1448	Aminotransferase
HXV88_19410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HXV88_19415	COG1328	CTP reductase activity
HXV88_19440	COG0543	2 iron, 2 sulfur cluster binding
HXV88_19440	COG0633	Ferredoxin
HXV88_19455	COG1215	transferase activity, transferring glycosyl groups
HXV88_19460	COG1649	PFAM Uncharacterised BCR, COG1649
HXV88_19460	COG0726	polysaccharide deacetylase
HXV88_19475	COG0840	transmembrane signaling receptor activity
HXV88_19480	COG3397	chitin binding
HXV88_19485	COG3174	membrane
HXV88_19490	COG0110	maltose O-acetyltransferase activity
HXV88_19505	COG1011	Hydrolase
HXV88_19510	COG0494	nUDIX hydrolase
HXV88_19515	COG1218	3'(2'),5'-bisphosphate nucleotidase
HXV88_19525	COG0814	amino acid
HXV88_19530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_19545	COG0626	cystathionine gamma-synthase activity
HXV88_19550	COG0460	homoserine dehydrogenase
HXV88_19550	COG0527	aspartate kinase activity
HXV88_19555	COG0306	phosphate transporter
HXV88_19560	COG1392	Phosphate transport regulator
HXV88_19570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HXV88_19575	COG2813	Specifically methylates the guanine in position
HXV88_19580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HXV88_19585	COG0297	glycogen (starch) synthase activity
HXV88_19625	COG1757	Na H antiporter
HXV88_19630	COG0316	Belongs to the HesB IscA family
HXV88_19640	COG0038	chloride channel
HXV88_19645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HXV88_19660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HXV88_19660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HXV88_19680	COG1204	response to ionizing radiation
HXV88_19735	COG2003	Belongs to the UPF0758 family
HXV88_19770	COG3311	Transcriptional regulator
HXV88_19795	COG3501	Rhs element vgr protein
HXV88_19830	COG0582	viral genome integration into host DNA
HXV88_19860	COG1396	sequence-specific DNA binding
HXV88_19865	COG3135	benzoate transporter
HXV88_19890	COG0840	transmembrane signaling receptor activity
HXV88_19895	COG3047	cAMP biosynthetic process
HXV88_19900	COG3706	GGDEF domain
HXV88_19905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HXV88_19940	COG2197	response regulator
HXV88_19955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HXV88_19965	COG1278	Cold shock
HXV88_19970	COG2252	PERMEase
HXV88_19975	COG2376	Dihydroxyacetone kinase
HXV88_19980	COG1461	Dihydroxyacetone kinase
HXV88_19985	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HXV88_19985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_19985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HXV88_19995	COG3284	Transcriptional regulator
HXV88_20005	COG0628	permease
HXV88_20010	COG0494	nUDIX hydrolase
HXV88_20025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HXV88_20050	COG0456	acetyltransferase
HXV88_20055	COG3133	Outer membrane lipoprotein
HXV88_20060	COG0004	ammonium transporteR
HXV88_20065	COG3706	GGDEF domain
HXV88_20075	COG3932	Exopolysaccharide synthesis, ExoD
HXV88_20080	COG0814	amino acid
HXV88_20085	COG3706	GGDEF domain
HXV88_20095	COG0110	maltose O-acetyltransferase activity
HXV88_20125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HXV88_20130	COG2022	thiamine diphosphate biosynthetic process
HXV88_20140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HXV88_20145	COG0352	thiamine-phosphate diphosphorylase activity
HXV88_20150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HXV88_20170	COG0745	RESPONSE REGULATOR receiver
HXV88_20175	COG0642	Histidine kinase
HXV88_20180	COG0189	ligase activity
HXV88_20230	COG0477	Major facilitator Superfamily
HXV88_20245	COG0312	modulator of DNA gyrase
HXV88_20250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HXV88_20260	COG3164	Protein of unknown function
HXV88_20265	COG1530	ribonuclease E activity
HXV88_20270	COG0424	maF-like protein
HXV88_20275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HXV88_20280	COG1792	Involved in formation and maintenance of cell shape
HXV88_20285	COG1077	Cell shape determining protein MreB Mrl
HXV88_20330	COG1459	type II secretion system
HXV88_20335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HXV88_20380	COG2199	diguanylate cyclase activity
HXV88_20380	COG2200	EAL domain
HXV88_20385	COG2200	EAL domain
HXV88_20390	COG0387	Pfam Sodium calcium exchanger
HXV88_20395	COG2986	histidine ammonia-lyase
HXV88_20400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HXV88_20405	COG0010	Belongs to the arginase family
HXV88_20410	COG1228	amidohydrolase
HXV88_20415	COG2188	Transcriptional regulator
HXV88_20420	COG0288	reversible hydration of carbon dioxide
HXV88_20430	COG2177	Part of the ABC transporter FtsEX involved in
HXV88_20435	COG2884	Cell division ATP-binding protein ftsE
HXV88_20440	COG0552	protein localization to endoplasmic reticulum
HXV88_20445	COG0742	ribosomal rna small subunit methyltransferase
HXV88_20470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HXV88_20475	COG0583	DNA-binding transcription factor activity
HXV88_20480	COG4221	oxidoreductase activity
HXV88_20495	COG1770	oligopeptidase
HXV88_20510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HXV88_20520	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HXV88_20530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_20540	COG2095	MarC family integral membrane protein
HXV88_20550	COG1301	dicarboxylic acid transport
HXV88_20575	COG3714	YhhN family
HXV88_20630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HXV88_20635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXV88_20640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HXV88_20645	COG0049	tRNA binding
HXV88_20650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HXV88_20655	COG2168	tRNA wobble position uridine thiolation
HXV88_20660	COG2923	Belongs to the DsrF TusC family
HXV88_20665	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HXV88_20675	COG2964	Protein conserved in bacteria
HXV88_20680	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HXV88_20685	COG0085	RNA polymerase activity
HXV88_20690	COG0222	ribosome binding
HXV88_20695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HXV88_20700	COG0081	regulation of translation
HXV88_20705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HXV88_20710	COG0250	Participates in transcription elongation, termination and antitermination
HXV88_20725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HXV88_20750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HXV88_20755	COG0569	domain protein
HXV88_20760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_20790	COG4191	Histidine kinase
HXV88_20790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HXV88_20795	COG3005	denitrification pathway
HXV88_20800	COG0243	molybdopterin cofactor binding
HXV88_20810	COG2205	protein histidine kinase activity
HXV88_20815	COG0745	RESPONSE REGULATOR receiver
HXV88_20845	COG2204	response regulator
HXV88_20855	COG2205	protein histidine kinase activity
HXV88_20870	COG1028	Short-chain dehydrogenase reductase Sdr
HXV88_20875	COG0516	GMP reductase activity
HXV88_20875	COG0517	IMP dehydrogenase activity
HXV88_20880	COG5413	integral membrane protein
HXV88_20890	COG1522	sequence-specific DNA binding
HXV88_20895	COG2502	aspartate--ammonia ligase
HXV88_20900	COG0542	response to heat
HXV88_20910	COG0564	pseudouridine synthase activity
HXV88_20915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HXV88_20920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HXV88_20930	COG3681	Belongs to the UPF0597 family
HXV88_20935	COG2964	Protein conserved in bacteria
HXV88_20945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HXV88_20950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HXV88_20955	COG1979	alcohol dehydrogenase
HXV88_20960	COG2207	Transcriptional regulator
HXV88_20965	COG3040	lipid binding
HXV88_20980	COG0583	DNA-binding transcription factor activity
HXV88_21000	COG0540	Belongs to the ATCase OTCase family
HXV88_21005	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HXV88_21010	COG1438	arginine binding
HXV88_21015	COG1288	antiporter activity
HXV88_21020	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HXV88_21050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HXV88_21060	COG3078	GTPase activator activity
HXV88_21070	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HXV88_21080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HXV88_21085	COG0408	coproporphyrinogen oxidase activity
HXV88_21090	COG0009	L-threonylcarbamoyladenylate synthase
HXV88_21100	COG0551	DNA topoisomerase type I activity
HXV88_21105	COG2922	Belongs to the Smg family
HXV88_21110	COG0758	DNA mediated transformation
HXV88_21115	COG1652	LysM domain
HXV88_21120	COG0242	peptide deformylase activity
HXV88_21125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HXV88_21130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HXV88_21130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HXV88_21135	COG0569	domain protein
HXV88_21140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_21150	COG0174	glutamine synthetase
HXV88_21165	COG2204	response regulator
HXV88_21170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HXV88_21175	COG1322	Protein conserved in bacteria
HXV88_21195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HXV88_21200	COG0583	DNA-binding transcription factor activity
HXV88_21205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HXV88_21205	COG0519	Catalyzes the synthesis of GMP from XMP
HXV88_21220	COG1396	sequence-specific DNA binding
HXV88_21225	COG1012	belongs to the aldehyde dehydrogenase family
HXV88_21235	COG2962	Rard protein
HXV88_21240	COG0840	transmembrane signaling receptor activity
HXV88_21245	COG2391	methyltransferase activity
HXV88_21260	COG0129	dihydroxy-acid dehydratase activity
HXV88_21270	COG3978	acetolactate synthase activity
HXV88_21280	COG0606	chelatase, subunit chli
HXV88_21285	COG0204	Acyl-transferase
HXV88_21290	COG0204	Acyl-transferase
HXV88_21295	COG1683	Conserved Protein
HXV88_21305	COG1335	isochorismatase
HXV88_21315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HXV88_21320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HXV88_21330	COG3084	Protein conserved in bacteria
HXV88_21335	COG2203	Gaf domain
HXV88_21335	COG5001	Diguanylate cyclase
HXV88_21335	COG3706	GGDEF domain
HXV88_21335	COG4251	negative regulation of phosphorylation
HXV88_21350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HXV88_21355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HXV88_21360	COG1561	YicC-like family, N-terminal region
HXV88_21365	COG0583	DNA-binding transcription factor activity
HXV88_21380	COG0583	DNA-binding transcription factor activity
HXV88_21420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HXV88_21425	COG0385	Bile acid
HXV88_21430	COG0531	amino acid
HXV88_21435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HXV88_21440	COG0531	amino acid
HXV88_21445	COG2731	YhcH YjgK YiaL family protein
HXV88_21450	COG3250	beta-galactosidase activity
HXV88_21455	COG1609	Transcriptional regulator
HXV88_21490	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HXV88_21495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_21495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HXV88_21500	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HXV88_21505	COG3074	FtsZ-dependent cytokinesis
HXV88_21515	COG1045	serine acetyltransferase
HXV88_21525	COG0745	RESPONSE REGULATOR receiver
HXV88_21530	COG2205	protein histidine kinase activity
HXV88_21535	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HXV88_21540	COG0534	Mate efflux family protein
HXV88_21555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HXV88_21560	COG2937	Belongs to the GPAT DAPAT family
HXV88_21565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HXV88_21570	COG3161	chorismate lyase activity
HXV88_21590	COG0604	alcohol dehydrogenase
HXV88_21595	COG1609	Transcriptional regulator
HXV88_21600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HXV88_21615	COG1519	Transferase
HXV88_21620	COG0859	PFAM glycosyl transferase family 9
HXV88_21625	COG0463	Glycosyl transferase, family 2
HXV88_21630	COG0859	PFAM glycosyl transferase family 9
HXV88_21635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HXV88_21640	COG2990	Protein conserved in bacteria
HXV88_21645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HXV88_21655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HXV88_21660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HXV88_21665	COG2003	Belongs to the UPF0758 family
HXV88_21670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HXV88_21680	COG4974	Belongs to the 'phage' integrase family
HXV88_21700	COG1278	Cold shock
HXV88_21710	COG5642	Protein of unknown function (DUF2384)
HXV88_21725	COG2916	Histone family protein nucleoid-structuring protein H-NS
HXV88_21755	COG0756	dUTP diphosphatase activity
HXV88_21765	COG1309	transcriptional regulator
HXV88_21770	COG0668	transmembrane transport
HXV88_21775	COG0166	Belongs to the GPI family
HXV88_21780	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HXV88_21800	COG1042	CoA-binding domain protein
HXV88_21800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HXV88_21800	COG0045	succinate-CoA ligase (ADP-forming) activity
HXV88_21830	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HXV88_21835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HXV88_21840	COG1739	Uncharacterized protein family UPF0029
HXV88_21845	COG0006	proline dipeptidase activity
HXV88_21850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HXV88_21855	COG1024	Enoyl-CoA hydratase
HXV88_21855	COG1250	3-hydroxyacyl-CoA dehydrogenase
HXV88_21860	COG0183	Belongs to the thiolase family
HXV88_21865	COG0745	RESPONSE REGULATOR receiver
HXV88_21870	COG2205	protein histidine kinase activity
HXV88_21885	COG0425	Belongs to the sulfur carrier protein TusA family
HXV88_21890	COG0251	oxidation-reduction process
HXV88_21895	COG2885	chlorophyll binding
HXV88_21900	COG2818	Glycosylase
HXV88_21905	COG0752	glycyl-tRNA synthetase alpha subunit
HXV88_21910	COG0751	glycine-tRNA ligase activity
HXV88_21955	COG2188	Transcriptional regulator
HXV88_21970	COG1609	Transcriptional regulator
HXV88_22000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HXV88_22010	COG2960	long-chain fatty acid transporting porin activity
HXV88_22015	COG5001	Diguanylate cyclase
HXV88_22025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HXV88_22040	COG3118	belongs to the thioredoxin family
HXV88_22045	COG0513	Belongs to the DEAD box helicase family
HXV88_22050	COG0248	Ppx GppA phosphatase
HXV88_22060	COG0742	ribosomal rna small subunit methyltransferase
HXV88_22080	COG3469	chitinase activity
HXV88_22085	COG3397	chitin binding
HXV88_22095	COG0084	hydrolase, TatD family'
HXV88_22100	COG0805	protein transport
HXV88_22105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_22110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HXV88_22115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HXV88_22120	COG3165	ubiquinone biosynthetic process from chorismate
HXV88_22125	COG2226	methyltransferase
HXV88_22130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HXV88_22135	COG0402	S-adenosylhomocysteine deaminase activity
HXV88_22140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HXV88_22185	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HXV88_22190	COG0848	biopolymer transport protein
HXV88_22195	COG0811	peptide transport
HXV88_22200	COG0811	peptide transport
HXV88_22210	COG2771	luxR family
HXV88_22215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HXV88_22220	COG1349	DNA-binding transcription factor activity
HXV88_22225	COG0745	RESPONSE REGULATOR receiver
HXV88_22230	COG2205	protein histidine kinase activity
HXV88_22245	COG4452	Inner membrane protein CreD
HXV88_22260	COG0297	glycogen (starch) synthase activity
HXV88_22260	COG0438	transferase activity, transferring glycosyl groups
HXV88_22305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HXV88_22310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HXV88_22315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HXV88_22320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HXV88_22325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HXV88_22330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HXV88_22335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HXV88_22340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HXV88_22350	COG0356	it plays a direct role in the translocation of protons across the membrane
HXV88_22360	COG1475	DNA binding
HXV88_22365	COG1192	Involved in chromosome partitioning
HXV88_22370	COG0357	Ribosomal RNA small subunit methyltransferase G
HXV88_22375	COG0445	tRNA wobble uridine modification
HXV88_22380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HXV88_22390	COG4615	Cyclic peptide transporter
HXV88_22395	COG1120	ATPase activity
HXV88_22400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HXV88_22405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HXV88_22410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HXV88_22415	COG0706	membrane insertase activity
HXV88_22420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HXV88_22425	COG0594	ribonuclease P activity
HXV88_22430	COG0230	Belongs to the bacterial ribosomal protein bL34 family