locus-tag	class	description
LAG74_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LAG74_00010	COG0592	DNA-directed DNA polymerase activity
LAG74_00020	COG0187	DNA topoisomerase II activity
LAG74_00030	COG2378	regulation of single-species biofilm formation
LAG74_00040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LAG74_00045	COG0071	Belongs to the small heat shock protein (HSP20) family
LAG74_00050	COG0071	Belongs to the small heat shock protein (HSP20) family
LAG74_00055	COG3977	Valine--pyruvate aminotransferase
LAG74_00070	COG2814	Major facilitator Superfamily
LAG74_00075	COG0745	RESPONSE REGULATOR receiver
LAG74_00080	COG2205	protein histidine kinase activity
LAG74_00100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LAG74_00105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_00105	COG4191	Histidine kinase
LAG74_00110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_00120	COG1309	transcriptional regulator
LAG74_00150	COG0561	phosphatase activity
LAG74_00155	COG2267	carboxylic ester hydrolase activity
LAG74_00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAG74_00170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAG74_00175	COG1758	RNA polymerase activity
LAG74_00180	COG0194	GDP metabolic process
LAG74_00185	COG0859	PFAM glycosyl transferase family 9
LAG74_00190	COG3642	lipopolysaccharide core region biosynthetic process
LAG74_00230	COG0589	response to stress
LAG74_00235	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LAG74_00240	COG1528	Iron-storage protein
LAG74_00245	COG2081	HI0933 family
LAG74_00250	COG3275	phosphorelay sensor kinase activity
LAG74_00255	COG3279	Response regulator of the LytR AlgR family
LAG74_00260	COG2223	nitrite transmembrane transporter activity
LAG74_00265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LAG74_00270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LAG74_00285	COG0583	DNA-binding transcription factor activity
LAG74_00290	COG4206	TonB-dependent receptor
LAG74_00295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LAG74_00325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LAG74_00330	COG2166	iron-sulfur cluster assembly
LAG74_00335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LAG74_00350	COG3245	cytochrome
LAG74_00355	COG1063	alcohol dehydrogenase
LAG74_00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LAG74_00380	COG3307	-O-antigen
LAG74_00410	COG1280	lysine exporter protein (LysE YggA)
LAG74_00455	COG0210	DNA helicase
LAG74_00460	COG1744	ABC transporter substrate-binding protein PnrA-like
LAG74_00465	COG3845	ABC transporter
LAG74_00470	COG4603	Belongs to the binding-protein-dependent transport system permease family
LAG74_00475	COG1079	Belongs to the binding-protein-dependent transport system permease family
LAG74_00480	COG0737	Belongs to the 5'-nucleotidase family
LAG74_00490	COG2239	Acts as a magnesium transporter
LAG74_00495	COG1648	precorrin-2 dehydrogenase activity
LAG74_00495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LAG74_00500	COG2116	formate transmembrane transporter activity
LAG74_00510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LAG74_00515	COG0842	Transport permease protein
LAG74_00520	COG0842	Transport permease protein
LAG74_00525	COG1131	(ABC) transporter
LAG74_00530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_00540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LAG74_00545	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LAG74_00555	COG0018	arginyl-trna synthetase
LAG74_00565	COG1595	DNA-templated transcription, initiation
LAG74_00575	COG1968	undecaprenyl-diphosphatase activity
LAG74_00580	COG2017	converts alpha-aldose to the beta-anomer
LAG74_00585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LAG74_00595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAG74_00600	COG1609	Transcriptional regulator
LAG74_00605	COG3250	beta-galactosidase activity
LAG74_00615	COG1129	ABC transporter
LAG74_00620	COG4211	Belongs to the binding-protein-dependent transport system permease family
LAG74_00630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAG74_00645	COG0366	Alpha amylase catalytic
LAG74_00660	COG0443	Heat shock 70 kDa protein
LAG74_00665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAG74_00670	COG3045	CreA protein
LAG74_00690	COG0174	glutamine synthetase
LAG74_00710	COG3842	ATPase activity
LAG74_00715	COG1176	ABC-type spermidine putrescine transport system, permease component I
LAG74_00720	COG1177	transmembrane transport
LAG74_00725	COG2258	MOSC domain
LAG74_00740	COG2050	protein possibly involved in aromatic compounds catabolism
LAG74_00745	COG0514	ATP-dependent DNA helicase (RecQ)
LAG74_00755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LAG74_00765	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LAG74_00770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LAG74_00785	COG0254	rRNA binding
LAG74_00790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LAG74_00800	COG0702	epimerase
LAG74_00805	COG0814	amino acid
LAG74_00810	COG0281	malic enzyme
LAG74_00815	COG1295	ribonuclease BN
LAG74_00820	COG1490	D-aminoacyl-tRNA deacylase activity
LAG74_00825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LAG74_00830	COG0456	acetyltransferase
LAG74_00840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LAG74_00845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAG74_00850	COG2610	gluconate transmembrane transporter activity
LAG74_00855	COG3265	gluconokinase activity
LAG74_00865	COG0800	Aldolase
LAG74_00870	COG1609	Transcriptional regulator
LAG74_00880	COG4942	peptidase
LAG74_00885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LAG74_00890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAG74_00895	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LAG74_00900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LAG74_00905	COG0316	Belongs to the HesB IscA family
LAG74_00905	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LAG74_00910	COG1040	competence protein
LAG74_00915	COG0596	Alpha beta hydrolase
LAG74_00935	COG2183	response to ionizing radiation
LAG74_00940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAG74_00960	COG0051	transcription antitermination factor activity, RNA binding
LAG74_00965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LAG74_00970	COG0088	Forms part of the polypeptide exit tunnel
LAG74_00975	COG0089	rRNA binding
LAG74_00980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LAG74_00985	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LAG74_00990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LAG74_00995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LAG74_01000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LAG74_01005	COG0255	Belongs to the universal ribosomal protein uL29 family
LAG74_01010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LAG74_01015	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LAG74_01020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LAG74_01025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LAG74_01030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LAG74_01035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LAG74_01040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LAG74_01045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
LAG74_01050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LAG74_01055	COG1841	ribosomal large subunit assembly
LAG74_01060	COG0200	Binds to the 23S rRNA
LAG74_01065	COG0201	protein transport
LAG74_01070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LAG74_01075	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LAG74_01080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LAG74_01085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LAG74_01090	COG0202	RNA polymerase activity
LAG74_01095	COG0203	ribosomal protein L17
LAG74_01135	COG4771	TonB-dependent receptor
LAG74_01140	COG3706	GGDEF domain
LAG74_01165	COG0583	DNA-binding transcription factor activity
LAG74_01175	COG1741	Belongs to the pirin family
LAG74_01180	COG2259	Doxx family
LAG74_01185	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LAG74_01190	COG1074	ATP-dependent DNA helicase activity
LAG74_01195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LAG74_01245	COG1175	transmembrane transport
LAG74_01255	COG3842	ATPase activity
LAG74_01285	COG2873	o-acetylhomoserine
LAG74_01295	COG4533	DNA binding
LAG74_01315	COG5380	lipid catabolic process
LAG74_01320	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LAG74_01325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LAG74_01350	COG0753	catalase activity
LAG74_01355	COG0456	acetyltransferase
LAG74_01355	COG0454	-acetyltransferase
LAG74_01380	COG2927	DNA polymerase III (CHI subunit)
LAG74_01385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LAG74_01390	COG0795	lipopolysaccharide-transporting ATPase activity
LAG74_01395	COG0795	lipopolysaccharide-transporting ATPase activity
LAG74_01410	COG0582	viral genome integration into host DNA
LAG74_01510	COG1494	fructose-1,6-bisphosphatase
LAG74_01525	COG2959	enzyme of heme biosynthesis
LAG74_01535	COG0181	hydroxymethylbilane synthase activity
LAG74_01540	COG3072	Adenylate cyclase
LAG74_01545	COG0400	carboxylic ester hydrolase activity
LAG74_01550	COG1965	Belongs to the frataxin family
LAG74_01560	COG0019	diaminopimelate decarboxylase activity
LAG74_01565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LAG74_01575	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LAG74_01580	COG1011	Hydrolase
LAG74_01600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LAG74_01605	COG3028	Belongs to the UPF0307 family
LAG74_01610	COG0312	modulator of DNA gyrase
LAG74_01615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LAG74_01620	COG5007	Belongs to the BolA IbaG family
LAG74_01630	COG2854	intermembrane phospholipid transfer
LAG74_01635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LAG74_01640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LAG74_01645	COG1127	ABC transporter
LAG74_01650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LAG74_01650	COG0517	IMP dehydrogenase activity
LAG74_01655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LAG74_01660	COG3117	lipopolysaccharide transmembrane transporter activity
LAG74_01665	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LAG74_01670	COG1137	ATPase activity
LAG74_01685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_01690	COG1660	Displays ATPase and GTPase activities
LAG74_01695	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_01700	COG3711	transcriptional antiterminator
LAG74_01700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_01715	COG3964	amidohydrolase
LAG74_01745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAG74_01750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LAG74_01760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LAG74_01765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LAG74_01770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LAG74_01775	COG0723	plastoquinol--plastocyanin reductase activity
LAG74_01780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LAG74_01785	COG2857	Cytochrome c1
LAG74_01790	COG0625	glutathione transferase activity
LAG74_01795	COG2969	positive regulation of protein catabolic process
LAG74_01800	COG2823	Periplasmic or secreted lipoprotein
LAG74_01805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LAG74_01810	COG0792	nuclease activity
LAG74_01815	COG3107	peptidoglycan biosynthetic process
LAG74_01820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LAG74_01830	COG2001	Belongs to the MraZ family
LAG74_01835	COG0275	rRNA processing
LAG74_01840	COG3116	cell division
LAG74_01845	COG0768	penicillin binding
LAG74_01855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LAG74_01860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAG74_01865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LAG74_01870	COG0772	Belongs to the SEDS family
LAG74_01875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LAG74_01880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAG74_01890	COG0849	cell division
LAG74_01895	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LAG74_01900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LAG74_01910	COG0653	protein targeting
LAG74_01915	COG0494	nUDIX hydrolase
LAG74_01920	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LAG74_01925	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LAG74_01940	COG1459	type II secretion system
LAG74_01945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAG74_01970	COG2186	Transcriptional regulator
LAG74_01975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LAG74_01980	COG0508	dehydrogenase complex catalyzes the overall conversion of
LAG74_01985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LAG74_01995	COG0840	transmembrane signaling receptor activity
LAG74_02000	COG1752	Esterase of the alpha-beta hydrolase superfamily
LAG74_02005	COG1049	propionate catabolic process, 2-methylcitrate cycle
LAG74_02010	COG2200	EAL domain
LAG74_02020	COG0523	cobalamin synthesis protein
LAG74_02025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_02040	COG2814	Major facilitator Superfamily
LAG74_02055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LAG74_02060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LAG74_02085	COG3314	Sporulation integral membrane protein YlbJ
LAG74_02105	COG0165	Argininosuccinate lyase
LAG74_02110	COG0137	argininosuccinate synthase activity
LAG74_02120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LAG74_02125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LAG74_02135	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LAG74_02150	COG3706	GGDEF domain
LAG74_02155	COG0814	amino acid
LAG74_02160	COG3385	transposase activity
LAG74_02165	COG3932	Exopolysaccharide synthesis, ExoD
LAG74_02175	COG3706	GGDEF domain
LAG74_02180	COG0004	ammonium transporteR
LAG74_02185	COG3133	Outer membrane lipoprotein
LAG74_02190	COG0456	acetyltransferase
LAG74_02210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LAG74_02215	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LAG74_02230	COG0494	nUDIX hydrolase
LAG74_02235	COG0628	permease
LAG74_02245	COG3284	Transcriptional regulator
LAG74_02260	COG1461	Dihydroxyacetone kinase
LAG74_02265	COG2376	Dihydroxyacetone kinase
LAG74_02270	COG2252	PERMEase
LAG74_02275	COG1278	Cold shock
LAG74_02285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LAG74_02300	COG1396	sequence-specific DNA binding
LAG74_02335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LAG74_02370	COG2197	response regulator
LAG74_02405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LAG74_02415	COG3047	cAMP biosynthetic process
LAG74_02420	COG0840	transmembrane signaling receptor activity
LAG74_02445	COG3135	benzoate transporter
LAG74_02450	COG1396	sequence-specific DNA binding
LAG74_02490	COG2926	Belongs to the UPF0265 family
LAG74_02500	COG0561	phosphatase activity
LAG74_02510	COG1546	Belongs to the CinA family
LAG74_02510	COG1058	Belongs to the CinA family
LAG74_02520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LAG74_02530	COG1522	sequence-specific DNA binding
LAG74_02535	COG1368	sulfuric ester hydrolase activity
LAG74_02575	COG4221	oxidoreductase activity
LAG74_02590	COG1979	alcohol dehydrogenase
LAG74_02595	COG1803	Methylglyoxal synthase
LAG74_02615	COG1444	tRNA N-acetyltransferase activity
LAG74_02625	COG0835	chemotaxis
LAG74_02625	COG0784	Response regulator, receiver
LAG74_02635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LAG74_02640	COG2949	membrane
LAG74_02645	COG3291	Pkd domain containing protein
LAG74_02650	COG0318	PFAM AMP-dependent synthetase and ligase
LAG74_02655	COG1441	menaquinone biosynthetic process
LAG74_02660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LAG74_02665	COG0596	Alpha beta hydrolase
LAG74_02670	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LAG74_02675	COG1169	isochorismate synthase
LAG74_02680	COG1575	Belongs to the MenA family. Type 1 subfamily
LAG74_02685	COG3385	transposase activity
LAG74_02710	COG0513	Belongs to the DEAD box helicase family
LAG74_02715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAG74_02720	COG1988	membrane-bound metal-dependent
LAG74_02725	COG1671	Belongs to the UPF0178 family
LAG74_02745	COG0484	heat shock protein binding
LAG74_02750	COG3263	regulation of cellular component size
LAG74_02755	COG3722	fumarate hydratase activity
LAG74_02760	COG0246	Mannitol dehydrogenase
LAG74_02765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_02765	COG2213	PTS system mannitol-specific
LAG74_02770	COG1560	Kdo2-lipid A biosynthetic process
LAG74_02775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LAG74_02775	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LAG74_02780	COG1538	Outer membrane efflux protein
LAG74_02785	COG0494	nUDIX hydrolase
LAG74_02790	COG3151	Protein conserved in bacteria
LAG74_02800	COG3150	esterase
LAG74_02825	COG3104	oligopeptide transport
LAG74_02860	COG0583	DNA-binding transcription factor activity
LAG74_02865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAG74_02885	COG0204	Acyl-transferase
LAG74_02890	COG1842	Phage shock protein A
LAG74_02905	COG2827	Endonuclease containing a URI domain
LAG74_02920	COG1573	uracil-dna glycosylase
LAG74_02925	COG0697	spore germination
LAG74_02930	COG0583	DNA-binding transcription factor activity
LAG74_02935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LAG74_02940	COG1121	(ABC) transporter
LAG74_02945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LAG74_02965	COG0739	heme binding
LAG74_02975	COG3068	Protein conserved in bacteria
LAG74_02995	COG0617	tRNA 3'-terminal CCA addition
LAG74_03000	COG1194	a g-specific adenine glycosylase
LAG74_03005	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LAG74_03015	COG3111	PFAM Bacterial OB fold (BOF) protein
LAG74_03020	COG3240	lipase activity
LAG74_03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LAG74_03025	COG2885	chlorophyll binding
LAG74_03030	COG3706	GGDEF domain
LAG74_03035	COG0557	exoribonuclease II activity
LAG74_03040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LAG74_03050	COG2153	protein acetylation
LAG74_03055	COG0513	Belongs to the DEAD box helicase family
LAG74_03060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LAG74_03085	COG0735	belongs to the Fur family
LAG74_03090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAG74_03095	COG0840	transmembrane signaling receptor activity
LAG74_03105	COG4166	transmembrane transport
LAG74_03115	COG0110	maltose O-acetyltransferase activity
LAG74_03125	COG1024	Enoyl-CoA hydratase
LAG74_03140	COG4221	oxidoreductase activity
LAG74_03145	COG0442	prolyl-tRNA aminoacylation
LAG74_03150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAG74_03160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LAG74_03160	COG3008	intermembrane lipid transfer
LAG74_03165	COG2995	paraquat-inducible protein a
LAG74_03175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAG74_03185	COG5001	Diguanylate cyclase
LAG74_03185	COG2203	Gaf domain
LAG74_03185	COG3706	GGDEF domain
LAG74_03185	COG4251	negative regulation of phosphorylation
LAG74_03190	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LAG74_03200	COG3916	Acyl-homoserine-lactone synthase
LAG74_03205	COG2771	luxR family
LAG74_03215	COG0840	transmembrane signaling receptor activity
LAG74_03220	COG0632	four-way junction helicase activity
LAG74_03225	COG2255	four-way junction helicase activity
LAG74_03235	COG1294	oxidase, subunit
LAG74_03240	COG4890	Cyd operon protein YbgT
LAG74_03245	COG3790	cyd operon protein YbgE
LAG74_03250	COG0824	Thioesterase
LAG74_03255	COG0811	peptide transport
LAG74_03270	COG0823	Involved in the tonB-independent uptake of proteins
LAG74_03275	COG2885	chlorophyll binding
LAG74_03280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LAG74_03345	COG0733	neurotransmitter:sodium symporter activity
LAG74_03355	COG0733	neurotransmitter:sodium symporter activity
LAG74_03370	COG0561	phosphatase activity
LAG74_03420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LAG74_03425	COG1640	4-alpha-glucanotransferase
LAG74_03430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LAG74_03435	COG0676	glucose-6-phosphate 1-epimerase activity
LAG74_03440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LAG74_03445	COG0840	transmembrane signaling receptor activity
LAG74_03450	COG1585	Membrane protein implicated in regulation of membrane protease activity
LAG74_03455	COG0330	HflC and HflK could
LAG74_03460	COG1648	precorrin-2 dehydrogenase activity
LAG74_03460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LAG74_03465	COG0175	sulfate reduction
LAG74_03470	COG2895	sulfate adenylyltransferase (ATP) activity
LAG74_03475	COG0471	metal ion transport
LAG74_03475	COG3273	potassium ion transport
LAG74_03480	COG0529	Catalyzes the synthesis of activated sulfate
LAG74_03500	COG0840	transmembrane signaling receptor activity
LAG74_03520	COG1136	(ABC) transporter
LAG74_03535	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
LAG74_03550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LAG74_03555	COG3437	response regulator, receiver
LAG74_03555	COG0784	Response regulator, receiver
LAG74_03565	COG2076	Multidrug Resistance protein
LAG74_03570	COG2076	Multidrug Resistance protein
LAG74_03575	COG0346	lactoylglutathione lyase activity
LAG74_03580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAG74_03585	COG1643	Atp-dependent helicase
LAG74_03595	COG1489	DNA binding
LAG74_03600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LAG74_03605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAG74_03615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LAG74_03620	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LAG74_03625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LAG74_03635	COG1823	symporter activity
LAG74_03655	COG1924	4 iron, 4 sulfur cluster binding
LAG74_03660	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
LAG74_03665	COG0842	Transport permease protein
LAG74_03670	COG1131	(ABC) transporter
LAG74_03685	COG0163	prenyltransferase activity
LAG74_03690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LAG74_03695	COG0671	phosphoesterase, PA-phosphatase related
LAG74_03700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAG74_03705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LAG74_03710	COG1151	hydroxylamine reductase activity
LAG74_03715	COG0783	Belongs to the Dps family
LAG74_03720	COG3023	N-Acetylmuramoyl-L-alanine amidase
LAG74_03725	COG4807	Protein conserved in bacteria
LAG74_03735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LAG74_03740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LAG74_03745	COG3956	TIGRFAM MazG family protein
LAG74_03750	COG0504	CTP synthase activity
LAG74_03755	COG0148	phosphopyruvate hydratase activity
LAG74_03795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LAG74_03805	COG0488	(ABC) transporter
LAG74_03810	COG0517	IMP dehydrogenase activity
LAG74_03810	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LAG74_03810	COG0617	tRNA 3'-terminal CCA addition
LAG74_03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAG74_03840	COG1794	racemase activity, acting on amino acids and derivatives
LAG74_03850	COG2731	YhcH YjgK YiaL family protein
LAG74_03860	COG0668	transmembrane transport
LAG74_03865	COG1376	ErfK ybiS ycfS ynhG family protein
LAG74_03875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LAG74_03880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LAG74_03885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LAG74_03890	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LAG74_03895	COG0585	pseudouridine synthase activity
LAG74_03900	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LAG74_03905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LAG74_03910	COG1238	metal cluster binding
LAG74_03925	COG1902	pentaerythritol trinitrate reductase activity
LAG74_03940	COG2957	Belongs to the agmatine deiminase family
LAG74_03945	COG0154	amidase activity
LAG74_03965	COG0513	Belongs to the DEAD box helicase family
LAG74_03980	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
LAG74_03985	COG1858	cytochrome C peroxidase
LAG74_03990	COG3385	transposase activity
LAG74_04040	COG4191	Histidine kinase
LAG74_04065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LAG74_04075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAG74_04080	COG4991	sh3 domain protein
LAG74_04090	COG2816	NAD+ diphosphatase activity
LAG74_04095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LAG74_04100	COG3385	transposase activity
LAG74_04105	COG1940	carbohydrate kinase activity
LAG74_04110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LAG74_04115	COG0126	phosphoglycerate kinase activity
LAG74_04120	COG0191	fructose-bisphosphate aldolase activity
LAG74_04125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAG74_04145	COG4232	protein-disulfide reductase activity
LAG74_04170	COG0354	folic acid binding
LAG74_04175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LAG74_04185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LAG74_04190	COG1595	DNA-templated transcription, initiation
LAG74_04195	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
LAG74_04200	COG3026	antisigma factor binding
LAG74_04210	COG0481	GTPase activity
LAG74_04215	COG0681	Belongs to the peptidase S26 family
LAG74_04230	COG1381	Involved in DNA repair and RecF pathway recombination
LAG74_04235	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LAG74_04245	COG2350	Protein conserved in bacteria
LAG74_04250	COG2917	probably involved in intracellular septation
LAG74_04255	COG0076	glutamate decarboxylase activity
LAG74_04260	COG1272	protein, Hemolysin III
LAG74_04265	COG2985	domain, Protein
LAG74_04265	COG0569	domain protein
LAG74_04285	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LAG74_04310	COG2313	pseudouridylate synthase activity
LAG74_04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_04355	COG1765	OsmC-like protein
LAG74_04370	COG3954	Phosphoribulokinase
LAG74_04375	COG3089	Belongs to the UPF0270 family
LAG74_04380	COG2203	Gaf domain
LAG74_04380	COG3706	GGDEF domain
LAG74_04380	COG4251	negative regulation of phosphorylation
LAG74_04380	COG5001	Diguanylate cyclase
LAG74_04385	COG0429	hydrolase of the alpha beta-hydrolase fold
LAG74_04390	COG0784	Response regulator, receiver
LAG74_04390	COG0835	chemotaxis
LAG74_04400	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LAG74_04405	COG1047	Peptidyl-prolyl cis-trans
LAG74_04420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LAG74_04445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAG74_04455	COG3721	Heme iron utilization protein
LAG74_04460	COG0748	coenzyme F420 binding
LAG74_04485	COG2814	Major facilitator Superfamily
LAG74_04490	COG3385	transposase activity
LAG74_04500	COG3655	Transcriptional regulator
LAG74_04510	COG5002	protein histidine kinase activity
LAG74_04510	COG2205	protein histidine kinase activity
LAG74_04510	COG0784	Response regulator, receiver
LAG74_04520	COG3706	GGDEF domain
LAG74_04535	COG3397	chitin binding
LAG74_04575	COG0835	chemotaxis
LAG74_04575	COG0784	Response regulator, receiver
LAG74_04580	COG2755	lipolytic protein G-D-S-L family
LAG74_04585	COG4181	ATPase activity
LAG74_04590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LAG74_04595	COG1090	epimerase
LAG74_04600	COG2200	EAL domain
LAG74_04605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAG74_04610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LAG74_04615	COG3171	Protein conserved in bacteria
LAG74_04620	COG2066	Belongs to the glutaminase family
LAG74_04625	COG2897	thiosulfate sulfurtransferase activity
LAG74_04640	COG0521	Mo-molybdopterin cofactor biosynthetic process
LAG74_04650	COG2966	Psort location CytoplasmicMembrane, score
LAG74_04655	COG3610	response to peptide
LAG74_04670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LAG74_04675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LAG74_04685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LAG74_04700	COG0786	glutamate:sodium symporter activity
LAG74_04705	COG0252	asparaginase activity
LAG74_04710	COG3139	Protein of unknown function (DUF1315)
LAG74_04730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LAG74_04735	COG0321	lipoyl(octanoyl) transferase activity
LAG74_04740	COG2921	Belongs to the UPF0250 family
LAG74_04745	COG1686	Belongs to the peptidase S11 family
LAG74_04750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LAG74_04755	COG2951	lytic endotransglycosylase activity
LAG74_04760	COG0772	Belongs to the SEDS family
LAG74_04765	COG0768	penicillin binding
LAG74_04770	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LAG74_04775	COG0799	negative regulation of ribosome biogenesis
LAG74_04780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LAG74_04795	COG0495	leucyl-tRNA aminoacylation
LAG74_04800	COG2888	peptidyl-tyrosine sulfation
LAG74_04805	COG0312	modulator of DNA gyrase
LAG74_04810	COG0312	modulator of DNA gyrase
LAG74_04815	COG0716	FMN binding
LAG74_04820	COG4974	Belongs to the 'phage' integrase family
LAG74_04825	COG1970	mechanosensitive ion channel activity
LAG74_04840	COG0789	Transcriptional regulator
LAG74_04845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LAG74_04850	COG4535	Mg2 and Co2 transporter CorC
LAG74_04855	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LAG74_04860	COG1702	phosphate starvation-inducible protein PhoH
LAG74_04865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LAG74_04870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAG74_04875	COG1335	isochorismatase
LAG74_04885	COG3706	GGDEF domain
LAG74_04920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LAG74_04930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LAG74_04940	COG0516	GMP reductase activity
LAG74_04950	COG0642	Histidine kinase
LAG74_04965	COG4221	oxidoreductase activity
LAG74_04975	COG1022	Amp-dependent synthetase and ligase
LAG74_04990	COG3214	Protein conserved in bacteria
LAG74_05000	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAG74_05005	COG0700	Nucleoside recognition
LAG74_05010	COG3366	ferrous iron transmembrane transporter activity
LAG74_05015	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LAG74_05020	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LAG74_05025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LAG74_05030	COG1053	succinate dehydrogenase
LAG74_05040	COG0584	glycerophosphoryl diester phosphodiesterase
LAG74_05045	COG3264	Mechanosensitive ion channel
LAG74_05045	COG1511	domain protein
LAG74_05055	COG0739	heme binding
LAG74_05065	COG0583	DNA-binding transcription factor activity
LAG74_05085	COG0583	DNA-binding transcription factor activity
LAG74_05090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LAG74_05120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LAG74_05125	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LAG74_05135	COG0338	D12 class N6 adenine-specific DNA methyltransferase
LAG74_05140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LAG74_05150	COG0180	Tryptophanyl-tRNA synthetase
LAG74_05160	COG0512	Glutamine amidotransferase of anthranilate synthase
LAG74_05165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LAG74_05175	COG1012	belongs to the aldehyde dehydrogenase family
LAG74_05190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAG74_05200	COG0674	pyruvate-flavodoxin oxidoreductase activity
LAG74_05200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LAG74_05200	COG1013	pyruvate-flavodoxin oxidoreductase activity
LAG74_05200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_05205	COG0366	Alpha amylase catalytic
LAG74_05215	COG3097	Belongs to the UPF0267 family
LAG74_05225	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LAG74_05235	COG0471	metal ion transport
LAG74_05235	COG0490	domain, Protein
LAG74_05310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LAG74_05315	COG1085	galactose-1-phosphate uridylyltransferase
LAG74_05320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LAG74_05325	COG1609	Transcriptional regulator
LAG74_05330	COG4580	involved in the transport of maltose and maltodextrins
LAG74_05355	COG2182	Extracellular solute-binding protein
LAG74_05360	COG1175	transmembrane transport
LAG74_05365	COG3833	ABC-type maltose transport systems, permease component
LAG74_05370	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LAG74_05375	COG1874	Beta-galactosidase
LAG74_05380	COG1263	PTS System
LAG74_05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_05390	COG0469	pyruvate kinase activity
LAG74_05405	COG2003	Belongs to the UPF0758 family
LAG74_05450	COG5377	YqaJ viral recombinase family
LAG74_05460	COG0012	GTP binding
LAG74_05465	COG0193	aminoacyl-tRNA hydrolase activity
LAG74_05470	COG0737	Belongs to the 5'-nucleotidase family
LAG74_05475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LAG74_05485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LAG74_05490	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LAG74_05495	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LAG74_05500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LAG74_05505	COG2890	protein-(glutamine-N5) methyltransferase activity
LAG74_05515	COG2912	Transglutaminase-like superfamily
LAG74_05520	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LAG74_05525	COG1301	dicarboxylic acid transport
LAG74_05540	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LAG74_05555	COG1881	PFAM PEBP family protein
LAG74_05560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LAG74_05575	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LAG74_05585	COG0583	DNA-binding transcription factor activity
LAG74_05590	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_05600	COG0616	signal peptide processing
LAG74_05610	COG3706	GGDEF domain
LAG74_05620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LAG74_05630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAG74_05635	COG0826	peptidase U32
LAG74_05640	COG2199	diguanylate cyclase activity
LAG74_05640	COG2200	EAL domain
LAG74_05640	COG2203	Gaf domain
LAG74_05665	COG2197	response regulator
LAG74_05695	COG3724	N-succinylarginine dihydrolase activity
LAG74_05715	COG0840	transmembrane signaling receptor activity
LAG74_05725	COG2971	BadF BadG BcrA BcrD
LAG74_05735	COG4608	Belongs to the ABC transporter superfamily
LAG74_05740	COG0444	Belongs to the ABC transporter superfamily
LAG74_05745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LAG74_05760	COG0784	Response regulator, receiver
LAG74_05760	COG2205	protein histidine kinase activity
LAG74_05790	COG3220	belongs to the UPF0276 family
LAG74_05820	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LAG74_05825	COG1289	transmembrane transporter activity
LAG74_05830	COG0303	'Molybdopterin
LAG74_05835	COG0746	molybdenum cofactor guanylyltransferase activity
LAG74_05845	COG4662	Binding-protein-dependent transport system inner membrane component
LAG74_05855	COG2204	response regulator
LAG74_05860	COG3852	Histidine kinase
LAG74_05870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LAG74_05910	COG3383	formate dehydrogenase (NAD+) activity
LAG74_05910	COG3383	formate dehydrogenase (NAD+) activity
LAG74_05915	COG0437	4 iron, 4 sulfur cluster binding
LAG74_05935	COG0281	malic enzyme
LAG74_05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_05985	COG0837	glucose binding
LAG74_05990	COG1737	Transcriptional regulator
LAG74_05995	COG0469	pyruvate kinase activity
LAG74_06015	COG1677	Flagellar hook-basal body complex protein FliE
LAG74_06025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LAG74_06075	COG1987	bacterial-type flagellum assembly
LAG74_06080	COG1684	flagellar biosynthetic protein fliR
LAG74_06090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LAG74_06115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LAG74_06120	COG2198	Histidine kinase
LAG74_06120	COG0784	Response regulator, receiver
LAG74_06120	COG0643	Histidine kinase
LAG74_06125	COG2201	protein-glutamate methylesterase activity
LAG74_06130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LAG74_06135	COG1360	Flagellar Motor Protein
LAG74_06140	COG1192	Involved in chromosome partitioning
LAG74_06150	COG0835	chemotaxis
LAG74_06165	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LAG74_06170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LAG74_06175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LAG74_06180	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
LAG74_06185	COG1138	Cytochrome C-type biogenesis protein
LAG74_06190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LAG74_06195	COG3088	subunit of a heme lyase
LAG74_06195	COG4235	cytochrome complex assembly
LAG74_06205	COG2853	Lipoprotein
LAG74_06215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LAG74_06220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LAG74_06230	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAG74_06235	COG1882	Formate acetyltransferase
LAG74_06245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAG74_06245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAG74_06275	COG0259	pyridoxamine-phosphate oxidase activity
LAG74_06300	COG2850	peptidyl-arginine hydroxylation
LAG74_06305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LAG74_06310	COG2915	High frequency lysogenization protein hflD homolog
LAG74_06315	COG0482	sulfurtransferase activity
LAG74_06325	COG1187	pseudouridine synthase activity
LAG74_06335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_06340	COG2271	Major facilitator Superfamily
LAG74_06345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_06345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_06345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_06370	COG0783	Belongs to the Dps family
LAG74_06410	COG1609	Transcriptional regulator
LAG74_06420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_06420	COG1263	PTS System
LAG74_06425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LAG74_06430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LAG74_06440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_06445	COG1960	acyl-CoA dehydrogenase activity
LAG74_06455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LAG74_06465	COG1940	carbohydrate kinase activity
LAG74_06470	COG0457	Tetratricopeptide repeat
LAG74_06475	COG0477	Major facilitator Superfamily
LAG74_06475	COG2814	Major facilitator Superfamily
LAG74_06485	COG3383	formate dehydrogenase (NAD+) activity
LAG74_06495	COG0784	Response regulator, receiver
LAG74_06495	COG2205	protein histidine kinase activity
LAG74_06505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LAG74_06510	COG2867	negative regulation of translational initiation
LAG74_06515	COG2914	Belongs to the UPF0125 (RnfH) family
LAG74_06520	COG3385	transposase activity
LAG74_06525	COG1473	amidohydrolase
LAG74_06530	COG1960	acyl-CoA dehydrogenase activity
LAG74_06535	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LAG74_06540	COG0121	glutamine amidotransferase
LAG74_06570	COG2197	response regulator
LAG74_06575	COG3850	Histidine kinase
LAG74_06580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LAG74_06585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAG74_06595	COG0243	molybdopterin cofactor binding
LAG74_06600	COG0437	4 iron, 4 sulfur cluster binding
LAG74_06605	COG0348	domain, Protein
LAG74_06615	COG3005	denitrification pathway
LAG74_06620	COG0521	Mo-molybdopterin cofactor biosynthetic process
LAG74_06625	COG0315	cyclic pyranopterin monophosphate synthase activity
LAG74_06630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LAG74_06635	COG0314	molybdopterin synthase activity
LAG74_06650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LAG74_06655	COG2267	carboxylic ester hydrolase activity
LAG74_06660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LAG74_06670	COG0302	gtp cyclohydrolase
LAG74_06675	COG0840	transmembrane signaling receptor activity
LAG74_06680	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LAG74_06690	COG0583	DNA-binding transcription factor activity
LAG74_06695	COG2353	YceI-like domain
LAG74_06705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LAG74_06720	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAG74_06725	COG1166	arginine decarboxylase activity
LAG74_06735	COG2015	COG2015, Alkyl sulfatase and related hydrolases
LAG74_06755	COG0814	amino acid
LAG74_06765	COG3681	Belongs to the UPF0597 family
LAG74_06770	COG2964	Protein conserved in bacteria
LAG74_06780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LAG74_06785	COG3385	transposase activity
LAG74_06790	COG1288	antiporter activity
LAG74_06795	COG0436	Aminotransferase
LAG74_06805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LAG74_06810	COG0739	heme binding
LAG74_06810	COG0741	lytic transglycosylase activity
LAG74_06810	COG1196	nuclear chromosome segregation
LAG74_06825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAG74_06835	COG0788	formyltetrahydrofolate deformylase activity
LAG74_06840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LAG74_06860	COG0791	NLP P60 protein
LAG74_06865	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
LAG74_06875	COG0471	metal ion transport
LAG74_06885	COG1376	ErfK ybiS ycfS ynhG family protein
LAG74_06885	COG1388	LysM domain
LAG74_06900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_06905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_06910	COG0745	RESPONSE REGULATOR receiver
LAG74_06915	COG5000	phosphorelay sensor kinase activity
LAG74_06915	COG5002	protein histidine kinase activity
LAG74_06940	COG1388	LysM domain
LAG74_06940	COG0741	lytic transglycosylase activity
LAG74_06945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LAG74_06950	COG2226	methyltransferase
LAG74_06955	COG0328	RNA-DNA hybrid ribonuclease activity
LAG74_06960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAG74_06970	COG3437	response regulator, receiver
LAG74_06970	COG0784	Response regulator, receiver
LAG74_06975	COG2375	cellular response to nickel ion
LAG74_06980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAG74_06985	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAG74_06990	COG1120	ATPase activity
LAG74_06995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LAG74_07005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_07010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_07045	COG0708	Exodeoxyribonuclease III
LAG74_07075	COG3132	Protein of unknown function, DUF480
LAG74_07080	COG3300	MHYT domain
LAG74_07080	COG5001	Diguanylate cyclase
LAG74_07090	COG2841	Protein conserved in bacteria
LAG74_07100	COG0534	Mate efflux family protein
LAG74_07135	COG1309	transcriptional regulator
LAG74_07170	COG3152	Membrane
LAG74_07185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_07190	COG0840	transmembrane signaling receptor activity
LAG74_07200	COG2207	Transcriptional regulator
LAG74_07205	COG0538	isocitrate dehydrogenase activity
LAG74_07215	COG3048	D-serine ammonia-lyase activity
LAG74_07220	COG2610	gluconate transmembrane transporter activity
LAG74_07225	COG0583	DNA-binding transcription factor activity
LAG74_07235	COG0791	NLP P60 protein
LAG74_07240	COG0583	DNA-binding transcription factor activity
LAG74_07245	COG0450	alkyl hydroperoxide reductase
LAG74_07265	COG0500	methyltransferase
LAG74_07270	COG4106	trans-aconitate 2-methyltransferase activity
LAG74_07275	COG1801	Protein of unknown function DUF72
LAG74_07285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LAG74_07290	COG0217	transcriptional regulatory protein
LAG74_07310	COG1012	belongs to the aldehyde dehydrogenase family
LAG74_07310	COG1454	alcohol dehydrogenase
LAG74_07315	COG2095	MarC family integral membrane protein
LAG74_07325	COG0601	transmembrane transport
LAG74_07330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LAG74_07345	COG0861	Integral membrane protein TerC family
LAG74_07350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LAG74_07380	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LAG74_07385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LAG74_07390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LAG74_07395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LAG74_07400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LAG74_07405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LAG74_07420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LAG74_07425	COG0505	Belongs to the CarA family
LAG74_07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LAG74_07440	COG0287	Prephenate dehydrogenase
LAG74_07440	COG1605	Chorismate mutase
LAG74_07445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LAG74_07455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LAG74_07460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LAG74_07495	COG0537	adenosine 5'-monophosphoramidase activity
LAG74_07510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LAG74_07525	COG1301	dicarboxylic acid transport
LAG74_07530	COG0840	transmembrane signaling receptor activity
LAG74_07545	COG2354	Protein conserved in bacteria
LAG74_07555	COG2233	PERMEase
LAG74_07560	COG3150	esterase
LAG74_07565	COG1252	NADH dehydrogenase
LAG74_07575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LAG74_07580	COG3300	MHYT domain
LAG74_07580	COG5001	Diguanylate cyclase
LAG74_07585	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAG74_07595	COG2373	Large extracellular alpha-helical protein
LAG74_07600	COG4953	penicillin-binding protein 1C
LAG74_07610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAG74_07610	COG0301	tRNA thio-modification
LAG74_07625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LAG74_07675	COG2089	acid synthase
LAG74_07685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
LAG74_07695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LAG74_07700	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LAG74_07710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LAG74_07715	COG1086	Polysaccharide biosynthesis protein
LAG74_07730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LAG74_07740	COG0483	inositol monophosphate 1-phosphatase activity
LAG74_07750	COG0625	glutathione transferase activity
LAG74_07755	COG2814	Major facilitator Superfamily
LAG74_07775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAG74_07780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LAG74_07790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LAG74_07795	COG0509	glycine decarboxylation via glycine cleavage system
LAG74_07800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LAG74_07800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LAG74_07805	COG0840	transmembrane signaling receptor activity
LAG74_07830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LAG74_07835	COG0574	Belongs to the PEP-utilizing enzyme family
LAG74_07835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LAG74_07840	COG3385	transposase activity
LAG74_07855	COG1464	Belongs to the NlpA lipoprotein family
LAG74_07860	COG3083	sulfuric ester hydrolase activity
LAG74_07865	COG3082	Protein of unknown function (DUF1414)
LAG74_07870	COG3081	Nucleoid-associated protein
LAG74_07880	COG1175	transmembrane transport
LAG74_07885	COG3833	ABC-type maltose transport systems, permease component
LAG74_07890	COG3842	ATPase activity
LAG74_07915	COG0425	Belongs to the sulfur carrier protein TusA family
LAG74_07920	COG4783	chaperone-mediated protein folding
LAG74_07930	COG1393	Belongs to the ArsC family
LAG74_07940	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LAG74_07950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_07955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LAG74_07960	COG2431	L-lysine efflux transmembrane transporter activity
LAG74_07970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_07980	COG4160	amino acid transport
LAG74_07985	COG0564	pseudouridine synthase activity
LAG74_08000	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LAG74_08010	COG0625	glutathione transferase activity
LAG74_08035	COG0642	Histidine kinase
LAG74_08040	COG2261	transglycosylase associated protein
LAG74_08055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAG74_08065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LAG74_08070	COG0215	cysteine-tRNA ligase activity
LAG74_08120	COG2119	membrane
LAG74_08150	COG0513	Belongs to the DEAD box helicase family
LAG74_08160	COG0493	'glutamate synthase
LAG74_08165	COG0069	glutamate synthase activity
LAG74_08165	COG0067	glutamate synthase
LAG74_08165	COG0070	glutamate synthase
LAG74_08170	COG1242	4 iron, 4 sulfur cluster binding
LAG74_08215	COG3634	alkyl hydroperoxide reductase activity
LAG74_08225	COG0517	IMP dehydrogenase activity
LAG74_08230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LAG74_08235	COG0343	queuine tRNA-ribosyltransferase activity
LAG74_08240	COG1862	Preprotein translocase
LAG74_08245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LAG74_08250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LAG74_08265	COG0826	peptidase U32
LAG74_08270	COG0826	peptidase U32
LAG74_08275	COG3154	lipid carrier protein
LAG74_08295	COG1104	cysteine desulfurase activity
LAG74_08300	COG0822	iron-sulfur transferase activity
LAG74_08310	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LAG74_08315	COG0443	Heat shock 70 kDa protein
LAG74_08320	COG0633	Ferredoxin
LAG74_08335	COG0105	UTP biosynthetic process
LAG74_08340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LAG74_08355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LAG74_08360	COG0124	histidyl-tRNA synthetase
LAG74_08365	COG2976	Protein conserved in bacteria
LAG74_08370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAG74_08375	COG1160	GTP binding
LAG74_08380	COG1645	bacterial-type flagellum-dependent swarming motility
LAG74_08385	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LAG74_08390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LAG74_08390	COG0047	phosphoribosylformylglycinamidine synthase activity
LAG74_08395	COG2199	diguanylate cyclase activity
LAG74_08395	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LAG74_08410	COG1007	ATP synthesis coupled electron transport
LAG74_08415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_08425	COG0713	ATP synthesis coupled electron transport
LAG74_08430	COG0839	Belongs to the complex I subunit 6 family
LAG74_08435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_08440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LAG74_08445	COG1034	ATP synthesis coupled electron transport
LAG74_08460	COG0649	NAD binding
LAG74_08460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_08465	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_08470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_08495	COG1770	oligopeptidase
LAG74_08500	COG4771	TonB-dependent receptor
LAG74_08505	COG1360	Flagellar Motor Protein
LAG74_08510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LAG74_08555	COG4974	Belongs to the 'phage' integrase family
LAG74_08575	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LAG74_08585	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LAG74_08590	COG4597	amino acid ABC transporter
LAG74_08595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_08600	COG0765	amino acid transport
LAG74_08605	COG1126	abc transporter atp-binding protein
LAG74_08615	COG0724	RNA recognition motif
LAG74_08620	COG4989	oxidoreductase activity
LAG74_08645	COG3437	response regulator, receiver
LAG74_08650	COG0583	DNA-binding transcription factor activity
LAG74_08655	COG5001	Diguanylate cyclase
LAG74_08655	COG3300	MHYT domain
LAG74_08660	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LAG74_08680	COG2814	Major facilitator Superfamily
LAG74_08695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LAG74_08700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LAG74_08705	COG0539	negative regulation of cytoplasmic translation
LAG74_08710	COG0776	regulation of translation
LAG74_08720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LAG74_08740	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LAG74_08745	COG0602	queuosine metabolic process
LAG74_08750	COG3530	Putative quorum-sensing-regulated virulence factor
LAG74_08755	COG2096	Adenosyltransferase
LAG74_08760	COG2916	Histone family protein nucleoid-structuring protein H-NS
LAG74_08765	COG1757	Na H antiporter
LAG74_08770	COG1435	thymidine kinase activity
LAG74_08790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LAG74_08795	COG0326	Molecular chaperone. Has ATPase activity
LAG74_08800	COG4172	Belongs to the ABC transporter superfamily
LAG74_08805	COG4172	Belongs to the ABC transporter superfamily
LAG74_08815	COG4168	peptide transport system, permease
LAG74_08825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LAG74_08830	COG1842	Phage shock protein A
LAG74_08845	COG3106	COG3106 Predicted ATPase
LAG74_08850	COG3768	UPF0283 membrane protein
LAG74_08855	COG0583	DNA-binding transcription factor activity
LAG74_08860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LAG74_08865	COG3842	ATPase activity
LAG74_08870	COG1176	ABC-type spermidine putrescine transport system, permease component I
LAG74_08875	COG1177	transmembrane transport
LAG74_08880	COG1012	belongs to the aldehyde dehydrogenase family
LAG74_08890	COG2154	pterin-4-alpha-carbinolamine dehydratase
LAG74_08910	COG2199	diguanylate cyclase activity
LAG74_08915	COG2885	chlorophyll binding
LAG74_08920	COG0861	Integral membrane protein TerC family
LAG74_08950	COG2910	NAD(P)H-binding
LAG74_08955	COG0583	DNA-binding transcription factor activity
LAG74_08960	COG0583	DNA-binding transcription factor activity
LAG74_08965	COG2271	Major facilitator Superfamily
LAG74_08975	COG1335	isochorismatase
LAG74_08990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LAG74_09000	COG0583	DNA-binding transcription factor activity
LAG74_09005	COG2723	6-phospho-beta-galactosidase activity
LAG74_09010	COG1944	ATP diphosphatase activity
LAG74_09015	COG2116	formate transmembrane transporter activity
LAG74_09020	COG1882	Formate acetyltransferase
LAG74_09025	COG2983	Belongs to the UPF0260 family
LAG74_09040	COG0058	SHG alpha-glucan phosphorylase activity
LAG74_09045	COG0471	metal ion transport
LAG74_09050	COG3118	belongs to the thioredoxin family
LAG74_09060	COG1132	(ABC) transporter
LAG74_09065	COG1132	(ABC) transporter
LAG74_09075	COG2501	S4 domain
LAG74_09090	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LAG74_09130	COG2009	succinate dehydrogenase
LAG74_09135	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LAG74_09140	COG1053	succinate dehydrogenase
LAG74_09150	COG0567	Dehydrogenase, E1 component
LAG74_09155	COG0508	dehydrogenase complex catalyzes the overall conversion of
LAG74_09160	COG0045	succinate-CoA ligase (ADP-forming) activity
LAG74_09175	COG1584	GPR1 FUN34 yaaH family protein
LAG74_09205	COG1024	Enoyl-CoA hydratase
LAG74_09210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LAG74_09215	COG1960	acyl-CoA dehydrogenase activity
LAG74_09220	COG1960	acyl-CoA dehydrogenase activity
LAG74_09225	COG1024	Enoyl-CoA hydratase
LAG74_09230	COG1024	Enoyl-CoA hydratase
LAG74_09240	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_09250	COG0730	response to heat
LAG74_09285	COG0784	Response regulator, receiver
LAG74_09285	COG2205	protein histidine kinase activity
LAG74_09325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LAG74_09330	COG1215	transferase activity, transferring glycosyl groups
LAG74_09335	COG0438	transferase activity, transferring glycosyl groups
LAG74_09390	COG0438	transferase activity, transferring glycosyl groups
LAG74_09410	COG0438	transferase activity, transferring glycosyl groups
LAG74_09415	COG0438	transferase activity, transferring glycosyl groups
LAG74_09420	COG2203	Gaf domain
LAG74_09420	COG3706	GGDEF domain
LAG74_09420	COG4251	negative regulation of phosphorylation
LAG74_09420	COG5001	Diguanylate cyclase
LAG74_09425	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LAG74_09430	COG0437	4 iron, 4 sulfur cluster binding
LAG74_09435	COG5557	Pfam Polysulphide reductase, NrfD
LAG74_09440	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LAG74_09445	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LAG74_09450	COG1773	rubredoxin
LAG74_09465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LAG74_09475	COG3842	ATPase activity
LAG74_09480	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
LAG74_09490	COG0375	protein maturation
LAG74_09495	COG0309	Hydrogenase expression formation protein (HypE)
LAG74_09505	COG0298	carbon dioxide binding
LAG74_09510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LAG74_09520	COG1921	L-seryl-tRNASec selenium transferase activity
LAG74_09530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LAG74_09540	COG3260	NADH ubiquinone oxidoreductase 20
LAG74_09545	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LAG74_09550	COG3261	NADH dehydrogenase
LAG74_09550	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LAG74_09555	COG0650	Formate hydrogenlyase subunit 4
LAG74_09560	COG0651	ATP synthesis coupled electron transport
LAG74_09565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAG74_09570	COG2188	Transcriptional regulator
LAG74_09580	COG3715	PTS system
LAG74_09585	COG3716	PTS system mannose fructose sorbose family IID component
LAG74_09590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_09595	COG4821	SIS domain
LAG74_09600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LAG74_09605	COG4821	SIS domain
LAG74_09620	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_09630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_09635	COG0800	Aldolase
LAG74_09645	COG3158	transport of potassium into the cell
LAG74_09650	COG0454	-acetyltransferase
LAG74_09665	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAG74_09690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LAG74_09695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAG74_09700	COG3046	protein related to deoxyribodipyrimidine photolyase
LAG74_09710	COG3033	Beta-eliminating lyase
LAG74_09715	COG0295	cytidine deaminase activity
LAG74_09720	COG1346	cytolysis
LAG74_09725	COG1380	Effector of murein hydrolase LrgA
LAG74_09730	COG3345	alpha-galactosidase
LAG74_09740	COG2925	Exonuclease
LAG74_09770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAG74_09780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAG74_09795	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LAG74_09930	COG5001	Diguanylate cyclase
LAG74_09940	COG0641	radical SAM
LAG74_09965	COG2304	oxidoreductase activity
LAG74_09970	COG2304	oxidoreductase activity
LAG74_09985	COG0714	Associated with various cellular activities
LAG74_09990	COG3119	arylsulfatase activity
LAG74_09995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LAG74_10000	COG0517	IMP dehydrogenase activity
LAG74_10000	COG0617	tRNA 3'-terminal CCA addition
LAG74_10000	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LAG74_10005	COG1643	Atp-dependent helicase
LAG74_10015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LAG74_10030	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
LAG74_10035	COG2067	long-chain fatty acid transport protein
LAG74_10040	COG2067	long-chain fatty acid transport protein
LAG74_10050	COG1595	DNA-templated transcription, initiation
LAG74_10060	COG2304	oxidoreductase activity
LAG74_10080	COG0714	Associated with various cellular activities
LAG74_10085	COG0183	Belongs to the thiolase family
LAG74_10090	COG1250	3-hydroxyacyl-CoA dehydrogenase
LAG74_10090	COG1024	Enoyl-CoA hydratase
LAG74_10095	COG2719	SpoVR family
LAG74_10100	COG2718	Belongs to the UPF0229 family
LAG74_10105	COG2766	serine protein kinase
LAG74_10110	COG0514	ATP-dependent DNA helicase (RecQ)
LAG74_10115	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LAG74_10125	COG0814	amino acid
LAG74_10130	COG0494	nUDIX hydrolase
LAG74_10145	COG2824	Alkylphosphonate utilization operon protein PhnA
LAG74_10175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LAG74_10270	COG3706	GGDEF domain
LAG74_10275	COG2840	Smr protein MutS2
LAG74_10280	COG2890	protein-(glutamine-N5) methyltransferase activity
LAG74_10285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LAG74_10295	COG0513	Belongs to the DEAD box helicase family
LAG74_10305	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LAG74_10320	COG0814	amino acid
LAG74_10325	COG1609	Transcriptional regulator
LAG74_10330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_10330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_10335	COG1105	Belongs to the carbohydrate kinase PfkB family
LAG74_10340	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LAG74_10340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_10340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_10345	COG1530	ribonuclease E activity
LAG74_10360	COG0424	maF-like protein
LAG74_10365	COG1399	metal-binding, possibly nucleic acid-binding protein
LAG74_10370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LAG74_10375	COG0416	fatty acid biosynthetic process
LAG74_10390	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_10395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LAG74_10400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAG74_10405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LAG74_10410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LAG74_10415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LAG74_10420	COG0470	DNA polymerase III
LAG74_10425	COG0084	hydrolase, TatD family'
LAG74_10440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAG74_10440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LAG74_10445	COG3008	intermembrane lipid transfer
LAG74_10450	COG2995	paraquat-inducible protein a
LAG74_10460	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LAG74_10465	COG0372	Belongs to the citrate synthase family
LAG74_10510	COG4221	oxidoreductase activity
LAG74_10515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LAG74_10520	COG3141	response to X-ray
LAG74_10615	COG4128	Pfam Zonular occludens toxin
LAG74_10655	COG1067	ATP-dependent peptidase activity
LAG74_10660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LAG74_10670	COG0488	(ABC) transporter
LAG74_10680	COG0116	Belongs to the methyltransferase superfamily
LAG74_10680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LAG74_10685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LAG74_10690	COG0254	rRNA binding
LAG74_10700	COG0167	dihydroorotate dehydrogenase activity
LAG74_10705	COG2902	Dehydrogenase
LAG74_10715	COG0308	aminopeptidase N
LAG74_10725	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LAG74_10730	COG1956	GAF domain-containing protein
LAG74_10740	COG3278	Belongs to the heme-copper respiratory oxidase family
LAG74_10755	COG2010	Cytochrome c
LAG74_10765	COG2217	Heavy metal translocating P-type atpase
LAG74_10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LAG74_10785	COG0589	response to stress
LAG74_10790	COG0037	tRNA processing
LAG74_10815	COG1177	transmembrane transport
LAG74_10830	COG0625	glutathione transferase activity
LAG74_10835	COG1869	D-ribose catabolic process
LAG74_10840	COG1129	ABC transporter
LAG74_10845	COG1172	Belongs to the binding-protein-dependent transport system permease family
LAG74_10850	COG1879	ABC-type sugar transport system periplasmic component
LAG74_10855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_10860	COG1609	Transcriptional regulator
LAG74_10865	COG5001	Diguanylate cyclase
LAG74_10865	COG3300	MHYT domain
LAG74_10890	COG0784	Response regulator, receiver
LAG74_10890	COG2205	protein histidine kinase activity
LAG74_10895	COG0776	regulation of translation
LAG74_10900	COG0072	phenylalanine-tRNA ligase activity
LAG74_10900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAG74_10905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LAG74_10910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LAG74_10915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LAG74_10920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LAG74_10925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LAG74_10945	COG0366	Alpha amylase catalytic
LAG74_10955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LAG74_10965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAG74_10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LAG74_10975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LAG74_10980	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LAG74_10985	COG3313	Fe-S protein
LAG74_10990	COG2942	2-epimerase
LAG74_10995	COG3716	PTS system mannose fructose sorbose family IID component
LAG74_11000	COG3715	PTS system
LAG74_11005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_11005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_11020	COG1609	Transcriptional regulator
LAG74_11025	COG2140	Oxalate decarboxylase
LAG74_11030	COG0306	phosphate transporter
LAG74_11035	COG0717	Belongs to the dCTP deaminase family
LAG74_11040	COG0572	uridine kinase
LAG74_11045	COG0489	protein tyrosine kinase activity
LAG74_11050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAG74_11050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAG74_11060	COG1254	Belongs to the acylphosphatase family
LAG74_11065	COG0840	transmembrane signaling receptor activity
LAG74_11080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LAG74_11095	COG0709	Synthesizes selenophosphate from selenide and ATP
LAG74_11100	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
LAG74_11105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LAG74_11115	COG0318	PFAM AMP-dependent synthetase and ligase
LAG74_11120	COG2267	carboxylic ester hydrolase activity
LAG74_11130	COG1214	PFAM Peptidase M22, glycoprotease
LAG74_11135	COG1199	ATP-dependent helicase activity
LAG74_11145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LAG74_11150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LAG74_11155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LAG74_11160	COG0131	Imidazoleglycerol-phosphate dehydratase
LAG74_11160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LAG74_11165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LAG74_11170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LAG74_11175	COG0107	imidazoleglycerol-phosphate synthase activity
LAG74_11190	COG2199	diguanylate cyclase activity
LAG74_11195	COG0318	PFAM AMP-dependent synthetase and ligase
LAG74_11200	COG1288	antiporter activity
LAG74_11210	COG3134	Outer membrane lipoprotein
LAG74_11215	COG2080	2 iron, 2 sulfur cluster binding
LAG74_11220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LAG74_11225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LAG74_11230	COG2252	PERMEase
LAG74_11235	COG0402	S-adenosylhomocysteine deaminase activity
LAG74_11240	COG2233	PERMEase
LAG74_11245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LAG74_11245	COG2080	2 iron, 2 sulfur cluster binding
LAG74_11250	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
LAG74_11255	COG0402	S-adenosylhomocysteine deaminase activity
LAG74_11260	COG0493	'glutamate synthase
LAG74_11260	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LAG74_11265	COG2068	MobA-Related Protein
LAG74_11270	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LAG74_11275	COG3608	succinylglutamate desuccinylase aspartoacylase
LAG74_11275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LAG74_11280	COG0697	spore germination
LAG74_11285	COG0549	Belongs to the carbamate kinase family
LAG74_11295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAG74_11300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LAG74_11305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LAG74_11335	COG0242	peptide deformylase activity
LAG74_11345	COG0693	protein deglycase activity
LAG74_11355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LAG74_11360	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LAG74_11365	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LAG74_11375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LAG74_11380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LAG74_11390	COG0205	6-phosphofructokinase activity
LAG74_11400	COG3123	guanosine phosphorylase activity
LAG74_11405	COG1760	l-serine dehydratase
LAG74_11410	COG1760	l-serine dehydratase
LAG74_11415	COG3100	YcgL domain-containing protein
LAG74_11420	COG0850	regulation of cytokinetic process
LAG74_11425	COG2894	cell division
LAG74_11430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LAG74_11435	COG3099	Belongs to the UPF0263 family
LAG74_11440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LAG74_11480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LAG74_11485	COG0697	spore germination
LAG74_11490	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LAG74_11495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAG74_11505	COG0307	riboflavin synthase, alpha
LAG74_11515	COG0534	Mate efflux family protein
LAG74_11545	COG3829	transcription factor binding
LAG74_11560	COG4681	YaeQ
LAG74_11575	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LAG74_11580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LAG74_11585	COG0586	Pfam SNARE associated Golgi protein
LAG74_11595	COG0556	nucleotide-excision repair
LAG74_11610	COG2985	domain, Protein
LAG74_11610	COG0569	domain protein
LAG74_11615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LAG74_11620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LAG74_11620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAG74_11635	COG3069	C4-dicarboxylate transmembrane transporter activity
LAG74_11650	COG1451	nucleotide metabolic process
LAG74_11665	COG0417	DNA replication proofreading
LAG74_11690	COG1560	Kdo2-lipid A biosynthetic process
LAG74_11695	COG1560	Kdo2-lipid A biosynthetic process
LAG74_11710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LAG74_11715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LAG74_11720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LAG74_11725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LAG74_11730	COG2832	Protein of unknown function (DUF454)
LAG74_11735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LAG74_11750	COG1011	Hydrolase
LAG74_11755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LAG74_11795	COG3593	DNA synthesis involved in DNA repair
LAG74_11810	COG0583	DNA-binding transcription factor activity
LAG74_11815	COG0730	response to heat
LAG74_11820	COG3148	PFAM DTW domain containing protein
LAG74_11825	COG1846	Transcriptional regulator
LAG74_11825	COG1940	carbohydrate kinase activity
LAG74_11830	COG0840	transmembrane signaling receptor activity
LAG74_11835	COG3012	SEC-C Motif Domain Protein
LAG74_11840	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LAG74_11845	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LAG74_11850	COG0247	lactate metabolic process
LAG74_11865	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
LAG74_11870	COG0437	4 iron, 4 sulfur cluster binding
LAG74_11875	COG3301	Polysulphide reductase, NrfD
LAG74_11880	COG1138	Cytochrome C-type biogenesis protein
LAG74_11890	COG3088	subunit of a heme lyase
LAG74_11890	COG4235	cytochrome complex assembly
LAG74_11905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LAG74_11915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LAG74_11925	COG1840	ABC-type Fe3 transport system, periplasmic component
LAG74_11930	COG3842	ATPase activity
LAG74_11940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAG74_11965	COG2801	Transposase and inactivated derivatives
LAG74_11980	COG1115	amino acid carrier protein
LAG74_11985	COG1024	Enoyl-CoA hydratase
LAG74_11995	COG2176	DNA-directed DNA polymerase activity
LAG74_12000	COG3162	membrane
LAG74_12005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LAG74_12010	COG0488	(ABC) transporter
LAG74_12015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAG74_12020	COG0776	regulation of translation
LAG74_12025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LAG74_12030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LAG74_12035	COG0740	serine-type endopeptidase activity
LAG74_12040	COG0544	peptidyl-prolyl cis-trans isomerase activity
LAG74_12050	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LAG74_12055	COG4591	ABC-type transport system involved in lipoprotein release permease component
LAG74_12060	COG1136	(ABC) transporter
LAG74_12065	COG4591	ABC-type transport system involved in lipoprotein release permease component
LAG74_12075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LAG74_12080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LAG74_12085	COG4166	transmembrane transport
LAG74_12090	COG0697	spore germination
LAG74_12100	COG2062	phosphohistidine phosphatase, SixA
LAG74_12105	COG1025	Belongs to the peptidase M16 family
LAG74_12145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LAG74_12145	COG0519	Catalyzes the synthesis of GMP from XMP
LAG74_12150	COG0516	GMP reductase activity
LAG74_12150	COG0517	IMP dehydrogenase activity
LAG74_12155	COG3038	cytochrome b561
LAG74_12160	COG1570	exodeoxyribonuclease VII activity
LAG74_12165	COG2188	Transcriptional regulator
LAG74_12170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_12170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_12170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LAG74_12175	COG0383	alpha-mannosidase activity
LAG74_12180	COG1181	Belongs to the D-alanine--D-alanine ligase family
LAG74_12190	COG0386	Belongs to the glutathione peroxidase family
LAG74_12195	COG0513	Belongs to the DEAD box helicase family
LAG74_12210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LAG74_12215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LAG74_12220	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LAG74_12270	COG5001	Diguanylate cyclase
LAG74_12270	COG3300	MHYT domain
LAG74_12285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_12295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LAG74_12300	COG0563	adenylate kinase activity
LAG74_12310	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LAG74_12315	COG1286	toxin biosynthetic process
LAG74_12325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LAG74_12330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LAG74_12335	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LAG74_12340	COG1674	ftsk spoiiie
LAG74_12340	COG0531	amino acid
LAG74_12350	COG0686	Belongs to the AlaDH PNT family
LAG74_12355	COG3385	transposase activity
LAG74_12360	COG0492	ferredoxin-NADP+ reductase activity
LAG74_12365	COG3706	GGDEF domain
LAG74_12370	COG3134	Outer membrane lipoprotein
LAG74_12375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LAG74_12380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LAG74_12385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LAG74_12390	COG0542	response to heat
LAG74_12395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LAG74_12400	COG1278	Cold shock
LAG74_12405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LAG74_12425	COG0745	RESPONSE REGULATOR receiver
LAG74_12430	COG2205	protein histidine kinase activity
LAG74_12440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LAG74_12440	COG0392	lysyltransferase activity
LAG74_12455	COG0659	secondary active sulfate transmembrane transporter activity
LAG74_12480	COG0514	ATP-dependent DNA helicase (RecQ)
LAG74_12500	COG0672	)-iron permease
LAG74_12520	COG2814	Major facilitator Superfamily
LAG74_12535	COG1136	(ABC) transporter
LAG74_12540	COG0577	efflux transmembrane transporter activity
LAG74_12560	COG0596	Alpha beta hydrolase
LAG74_12580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LAG74_12585	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LAG74_12585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LAG74_12590	COG0527	aspartate kinase activity
LAG74_12600	COG1368	sulfuric ester hydrolase activity
LAG74_12605	COG1619	proteins homologs of microcin C7 resistance protein MccF
LAG74_12610	COG4667	esterase of the alpha-beta hydrolase superfamily
LAG74_12630	COG1648	precorrin-2 dehydrogenase activity
LAG74_12630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LAG74_12640	COG0393	Putative heavy-metal-binding
LAG74_12645	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LAG74_12650	COG0285	dihydrofolate synthase activity
LAG74_12655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LAG74_12660	COG0101	tRNA pseudouridine synthase activity
LAG74_12670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LAG74_12675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LAG74_12680	COG0671	phosphoesterase, PA-phosphatase related
LAG74_12685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LAG74_12690	COG2056	Na+-H+ antiporter family
LAG74_12700	COG2050	protein possibly involved in aromatic compounds catabolism
LAG74_12710	COG0247	lactate metabolic process
LAG74_12710	COG0277	FAD linked oxidase domain protein
LAG74_12755	COG3941	tape measure
LAG74_12780	COG4397	Mu-like prophage major head subunit gpT
LAG74_12785	COG4388	Caudovirus prohead serine protease
LAG74_12805	COG4383	Mu-like prophage protein gp29
LAG74_12810	COG4373	Mu-like prophage FluMu protein gp28
LAG74_12820	COG0640	Transcriptional regulator
LAG74_12950	COG1253	flavin adenine dinucleotide binding
LAG74_12955	COG1902	pentaerythritol trinitrate reductase activity
LAG74_12970	COG0647	UMP catabolic process
LAG74_12975	COG4651	solute:proton antiporter activity
LAG74_12975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LAG74_12985	COG0367	asparagine synthase
LAG74_13015	COG0322	excinuclease ABC activity
LAG74_13020	COG2197	response regulator
LAG74_13025	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LAG74_13030	COG2835	tetraacyldisaccharide 4'-kinase activity
LAG74_13035	COG1663	tetraacyldisaccharide 4'-kinase activity
LAG74_13045	COG2333	competence protein COMEC
LAG74_13045	COG0658	competence protein
LAG74_13060	COG1448	Aminotransferase
LAG74_13070	COG0583	DNA-binding transcription factor activity
LAG74_13075	COG3085	chromosome segregation
LAG74_13080	COG4574	serine-type endopeptidase inhibitor activity
LAG74_13085	COG0584	glycerophosphoryl diester phosphodiesterase
LAG74_13095	COG1349	DNA-binding transcription factor activity
LAG74_13100	COG2271	Major facilitator Superfamily
LAG74_13105	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LAG74_13110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LAG74_13115	COG0840	transmembrane signaling receptor activity
LAG74_13125	COG0583	DNA-binding transcription factor activity
LAG74_13150	COG0656	L-ascorbic acid biosynthetic process
LAG74_13160	COG2814	Major facilitator Superfamily
LAG74_13165	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAG74_13180	COG3220	belongs to the UPF0276 family
LAG74_13200	COG1294	oxidase, subunit
LAG74_13210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LAG74_13220	COG2979	Protein of unknown function (DUF533)
LAG74_13235	COG0583	DNA-binding transcription factor activity
LAG74_13240	COG2807	transmembrane transport
LAG74_13245	COG1187	pseudouridine synthase activity
LAG74_13255	COG0346	lactoylglutathione lyase activity
LAG74_13265	COG1403	HNH endonuclease
LAG74_13270	COG4657	Part of a membrane complex involved in electron transport
LAG74_13275	COG2878	Part of a membrane complex involved in electron transport
LAG74_13280	COG4656	Part of a membrane complex involved in electron transport
LAG74_13285	COG4658	electron transport chain
LAG74_13290	COG4659	FMN binding
LAG74_13295	COG4660	Part of a membrane complex involved in electron transport
LAG74_13300	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LAG74_13305	COG0346	lactoylglutathione lyase activity
LAG74_13340	COG1199	ATP-dependent helicase activity
LAG74_13350	COG0123	including yeast histone deacetylase and acetoin utilization protein
LAG74_13355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LAG74_13360	COG1785	Belongs to the alkaline phosphatase family
LAG74_13380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LAG74_13385	COG2197	response regulator
LAG74_13395	COG2271	Major facilitator Superfamily
LAG74_13400	COG3706	GGDEF domain
LAG74_13405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_13410	COG0765	amino acid transport
LAG74_13415	COG1126	abc transporter atp-binding protein
LAG74_13430	COG0531	amino acid
LAG74_13445	COG1253	flavin adenine dinucleotide binding
LAG74_13450	COG0704	Plays a role in the regulation of phosphate uptake
LAG74_13455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LAG74_13460	COG0581	inorganic phosphate transmembrane transporter activity
LAG74_13465	COG0573	inorganic phosphate transmembrane transporter activity
LAG74_13470	COG0590	tRNA wobble adenosine to inosine editing
LAG74_13485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LAG74_13505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LAG74_13510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LAG74_13515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LAG74_13520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LAG74_13545	COG2716	regulation of RNA biosynthetic process
LAG74_13550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LAG74_13560	COG2239	Acts as a magnesium transporter
LAG74_13565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LAG74_13580	COG1706	bacterial-type flagellum-dependent cell motility
LAG74_13585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LAG74_13595	COG4787	bacterial-type flagellum-dependent cell motility
LAG74_13615	COG1815	bacterial-type flagellum-dependent cell motility
LAG74_13620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LAG74_13625	COG0835	chemotaxis
LAG74_13625	COG0784	Response regulator, receiver
LAG74_13630	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LAG74_13645	COG0622	Phosphoesterase
LAG74_13650	COG4166	transmembrane transport
LAG74_13660	COG1187	pseudouridine synthase activity
LAG74_13665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LAG74_13675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LAG74_13690	COG1349	DNA-binding transcription factor activity
LAG74_13695	COG0697	spore germination
LAG74_13700	COG4166	transmembrane transport
LAG74_13725	COG1278	Cold shock
LAG74_13750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LAG74_13750	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LAG74_13755	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_13760	COG1535	isochorismatase
LAG74_13760	COG3433	isochorismatase activity
LAG74_13765	COG1021	2,3-dihydroxybenzoate-AMP ligase
LAG74_13770	COG1169	isochorismate synthase
LAG74_13775	COG4771	TonB-dependent receptor
LAG74_13780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LAG74_13785	COG1609	Transcriptional regulator
LAG74_13790	COG0741	lytic transglycosylase activity
LAG74_13800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LAG74_13820	COG2911	Protein conserved in bacteria
LAG74_13825	COG0729	surface antigen
LAG74_13835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAG74_13845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LAG74_13850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LAG74_13855	COG4134	Bacterial extracellular solute-binding protein
LAG74_13865	COG4136	ATPase activity
LAG74_13870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LAG74_13875	COG2951	lytic endotransglycosylase activity
LAG74_13880	COG3385	transposase activity
LAG74_13885	COG1846	Transcriptional regulator
LAG74_13895	COG0033	Phosphoglucomutase
LAG74_13900	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
LAG74_13905	COG0596	Alpha beta hydrolase
LAG74_13920	COG0716	FMN binding
LAG74_13930	COG0735	belongs to the Fur family
LAG74_13940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAG74_13950	COG1263	PTS System
LAG74_13950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_13950	COG2190	(PTS) system
LAG74_13955	COG0363	glucosamine-6-phosphate deaminase activity
LAG74_13960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LAG74_13965	COG1940	carbohydrate kinase activity
LAG74_13965	COG1846	Transcriptional regulator
LAG74_13970	COG2194	sulfuric ester hydrolase activity
LAG74_13975	COG2199	diguanylate cyclase activity
LAG74_13975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LAG74_13980	COG3275	phosphorelay sensor kinase activity
LAG74_13985	COG3279	Response regulator of the LytR AlgR family
LAG74_13990	COG1966	Carbon starvation protein
LAG74_14005	COG1566	PFAM secretion protein HlyD family protein
LAG74_14010	COG1061	Type III restriction enzyme res subunit
LAG74_14015	COG2027	D-alanyl-D-alanine carboxypeptidase
LAG74_14020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LAG74_14025	COG3021	interspecies interaction between organisms
LAG74_14035	COG1607	acyl-coa hydrolase
LAG74_14040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LAG74_14050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LAG74_14050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LAG74_14050	COG1013	pyruvate-flavodoxin oxidoreductase activity
LAG74_14050	COG0674	pyruvate-flavodoxin oxidoreductase activity
LAG74_14065	COG0633	Ferredoxin
LAG74_14065	COG3217	Mosc domain protein beta barrel domain protein
LAG74_14065	COG0633	Ferredoxin
LAG74_14065	COG3217	Mosc domain protein beta barrel domain protein
LAG74_14075	COG0501	Belongs to the peptidase M48B family
LAG74_14080	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LAG74_14085	COG1073	alpha beta
LAG74_14085	COG2226	methyltransferase
LAG74_14090	COG0156	8-amino-7-oxononanoate synthase activity
LAG74_14095	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LAG74_14100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LAG74_14115	COG0017	Asparaginyl-tRNA synthetase
LAG74_14125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LAG74_14135	COG1473	amidohydrolase
LAG74_14140	COG3069	C4-dicarboxylate transmembrane transporter activity
LAG74_14155	COG1393	Belongs to the ArsC family
LAG74_14160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LAG74_14165	COG1876	peptidase activity
LAG74_14175	COG3263	regulation of cellular component size
LAG74_14190	COG1280	lysine exporter protein (LysE YggA)
LAG74_14215	COG1957	nucleoside hydrolase
LAG74_14220	COG0564	pseudouridine synthase activity
LAG74_14230	COG1454	alcohol dehydrogenase
LAG74_14280	COG4964	Belongs to the GSP D family
LAG74_14310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAG74_14315	COG0702	epimerase
LAG74_14325	COG3385	transposase activity
LAG74_14330	COG0095	Lipoate-protein ligase
LAG74_14340	COG0577	efflux transmembrane transporter activity
LAG74_14340	COG1136	(ABC) transporter
LAG74_14345	COG1136	(ABC) transporter
LAG74_14345	COG0577	efflux transmembrane transporter activity
LAG74_14350	COG1136	(ABC) transporter
LAG74_14350	COG0577	efflux transmembrane transporter activity
LAG74_14355	COG1566	PFAM secretion protein HlyD family protein
LAG74_14390	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAG74_14400	COG1285	pathogenesis
LAG74_14430	COG0484	heat shock protein binding
LAG74_14435	COG0443	Heat shock 70 kDa protein
LAG74_14440	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LAG74_14445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LAG74_14450	COG0497	DNA recombination
LAG74_14455	COG1227	inorganic diphosphatase activity
LAG74_14460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_14465	COG0577	efflux transmembrane transporter activity
LAG74_14465	COG1136	(ABC) transporter
LAG74_14485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAG74_14505	COG0489	protein tyrosine kinase activity
LAG74_14505	COG3206	protein involved in exopolysaccharide biosynthesis
LAG74_14510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LAG74_14515	COG1596	polysaccharide export
LAG74_14565	COG0110	maltose O-acetyltransferase activity
LAG74_14575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LAG74_14590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LAG74_14610	COG2030	dehydratase
LAG74_14630	COG0463	Glycosyl transferase, family 2
LAG74_14660	COG1091	dTDP-4-dehydrorhamnose reductase activity
LAG74_14670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LAG74_14675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_14680	COG1309	transcriptional regulator
LAG74_14695	COG1342	Belongs to the UPF0251 family
LAG74_14770	COG2181	nitrate reductase activity
LAG74_14775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LAG74_14780	COG1140	nitrate reductase beta subunit
LAG74_14785	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LAG74_14790	COG2223	nitrite transmembrane transporter activity
LAG74_14800	COG2197	response regulator
LAG74_14815	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAG74_14820	COG1773	rubredoxin
LAG74_14820	COG0426	domain, Protein
LAG74_14825	COG3604	Transcriptional regulator
LAG74_14830	COG2197	response regulator
LAG74_14835	COG2199	diguanylate cyclase activity
LAG74_14835	COG2203	Gaf domain
LAG74_14850	COG2199	diguanylate cyclase activity
LAG74_14850	COG2203	Gaf domain
LAG74_14855	COG0589	response to stress
LAG74_14860	COG0659	secondary active sulfate transmembrane transporter activity
LAG74_14880	COG2916	Histone family protein nucleoid-structuring protein H-NS
LAG74_14900	COG3621	Patatin-like phospholipase
LAG74_14925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LAG74_14940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LAG74_14950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LAG74_14955	COG0083	homoserine kinase activity
LAG74_14965	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LAG74_14970	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LAG74_14975	COG1946	Acyl-CoA thioesterase
LAG74_14980	COG1312	Catalyzes the dehydration of D-mannonate
LAG74_14985	COG2186	Transcriptional regulator
LAG74_14995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
LAG74_15005	COG0246	Mannitol dehydrogenase
LAG74_15010	COG1904	glucuronate isomerase
LAG74_15015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_15020	COG0800	Aldolase
LAG74_15030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LAG74_15040	COG0009	L-threonylcarbamoyladenylate synthase
LAG74_15050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LAG74_15055	COG0512	Glutamine amidotransferase of anthranilate synthase
LAG74_15055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LAG74_15060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LAG74_15065	COG0134	indole-3-glycerol-phosphate synthase activity
LAG74_15065	COG0135	phosphoribosylanthranilate isomerase activity
LAG74_15070	COG0133	tryptophan synthase activity
LAG74_15075	COG0159	tryptophan synthase activity
LAG74_15090	COG1988	membrane-bound metal-dependent
LAG74_15110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAG74_15120	COG0798	PFAM Bile acid sodium symporter
LAG74_15150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LAG74_15160	COG0745	RESPONSE REGULATOR receiver
LAG74_15175	COG4988	ABC transporter
LAG74_15180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LAG74_15200	COG1720	tRNA m6t6A37 methyltransferase activity
LAG74_15205	COG3038	cytochrome b561
LAG74_15245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LAG74_15250	COG1396	sequence-specific DNA binding
LAG74_15250	COG1917	Cupin 2, conserved barrel domain protein
LAG74_15265	COG0531	amino acid
LAG74_15275	COG0531	amino acid
LAG74_15285	COG1283	sodium-dependent phosphate transmembrane transporter activity
LAG74_15290	COG0545	Peptidyl-prolyl cis-trans isomerase
LAG74_15300	COG3385	transposase activity
LAG74_15305	COG2974	May be involved in recombination
LAG74_15315	COG0420	3'-5' exonuclease activity
LAG74_15320	COG0419	ATPase involved in DNA repair
LAG74_15325	COG3384	dioxygenase
LAG74_15335	COG0469	pyruvate kinase activity
LAG74_15340	COG3264	Mechanosensitive ion channel
LAG74_15340	COG1196	nuclear chromosome segregation
LAG74_15350	COG3590	peptidase
LAG74_15360	COG2190	(PTS) system
LAG74_15370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_15375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LAG74_15380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LAG74_15395	COG3437	response regulator, receiver
LAG74_15395	COG2770	Histidine kinase
LAG74_15400	COG3409	Peptidoglycan-binding domain 1 protein
LAG74_15400	COG3267	Type II secretory pathway component ExeA
LAG74_15420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAG74_15425	COG1459	type II secretion system
LAG74_15430	COG2165	general secretion pathway protein
LAG74_15440	COG2165	general secretion pathway protein
LAG74_15450	COG3156	type II secretion system protein K
LAG74_15460	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
LAG74_15470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAG74_15475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAG74_15480	COG2723	6-phospho-beta-galactosidase activity
LAG74_15485	COG1447	Phosphotransferase system cellobiose-specific component IIA
LAG74_15490	COG1917	Cupin 2, conserved barrel domain protein
LAG74_15490	COG2169	Transcriptional regulator
LAG74_15495	COG1486	melibiose metabolic process
LAG74_15510	COG0670	Belongs to the BI1 family
LAG74_15515	COG1289	transmembrane transporter activity
LAG74_15520	COG2920	part of a sulfur-relay system
LAG74_15525	COG0673	inositol 2-dehydrogenase activity
LAG74_15530	COG0583	DNA-binding transcription factor activity
LAG74_15560	COG3152	Membrane
LAG74_15595	COG1032	radical SAM domain protein
LAG74_15605	COG1566	PFAM secretion protein HlyD family protein
LAG74_15610	COG3706	GGDEF domain
LAG74_15615	COG1752	Esterase of the alpha-beta hydrolase superfamily
LAG74_15620	COG0531	amino acid
LAG74_15650	COG0281	malic enzyme
LAG74_15660	COG0534	Mate efflux family protein
LAG74_15675	COG2233	PERMEase
LAG74_15680	COG0095	Lipoate-protein ligase
LAG74_15685	COG1115	amino acid carrier protein
LAG74_15690	COG0019	diaminopimelate decarboxylase activity
LAG74_15700	COG0678	peroxiredoxin activity
LAG74_15725	COG0545	Peptidyl-prolyl cis-trans isomerase
LAG74_15730	COG3142	Participates in the control of copper homeostasis
LAG74_15755	COG5002	protein histidine kinase activity
LAG74_15760	COG0745	RESPONSE REGULATOR receiver
LAG74_15765	COG0346	lactoylglutathione lyase activity
LAG74_15770	COG3284	Transcriptional regulator
LAG74_15785	COG0697	spore germination
LAG74_15795	COG3290	protein histidine kinase activity
LAG74_15800	COG0281	malic enzyme
LAG74_15815	COG1846	Transcriptional regulator
LAG74_15820	COG1566	PFAM secretion protein HlyD family protein
LAG74_15850	COG0602	queuosine metabolic process
LAG74_15860	COG1328	CTP reductase activity
LAG74_15870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LAG74_15875	COG3115	cell septum assembly
LAG74_15880	COG1196	nuclear chromosome segregation
LAG74_15890	COG2860	membrane
LAG74_15900	COG3108	Peptidase M15
LAG74_15905	COG2989	Protein conserved in bacteria
LAG74_15920	COG0463	Glycosyl transferase, family 2
LAG74_15935	COG0366	Alpha amylase catalytic
LAG74_15970	COG2203	Gaf domain
LAG74_15970	COG2199	diguanylate cyclase activity
LAG74_15980	COG3590	peptidase
LAG74_15990	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LAG74_15995	COG1982	Orn Lys Arg decarboxylase major
LAG74_16000	COG0531	amino acid
LAG74_16005	COG3710	Transcriptional regulator
LAG74_16010	COG0531	amino acid
LAG74_16030	COG0814	amino acid
LAG74_16060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LAG74_16065	COG0739	heme binding
LAG74_16070	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LAG74_16080	COG0251	oxidation-reduction process
LAG74_16090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LAG74_16100	COG3091	SprT-like family
LAG74_16110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LAG74_16115	COG0189	ligase activity
LAG74_16120	COG1678	Uncharacterized ACR, COG1678
LAG74_16125	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LAG74_16130	COG3104	oligopeptide transport
LAG74_16145	COG0714	Associated with various cellular activities
LAG74_16160	COG1115	amino acid carrier protein
LAG74_16165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LAG74_16175	COG0825	malonyl-CoA metabolic process
LAG74_16185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LAG74_16190	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAG74_16195	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAG74_16200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LAG74_16205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LAG74_16220	COG0750	zinc metalloprotease
LAG74_16225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LAG74_16230	COG0575	Belongs to the CDS family
LAG74_16235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LAG74_16240	COG0233	cytoplasmic translational termination
LAG74_16245	COG0528	UMP kinase activity
LAG74_16250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LAG74_16255	COG0052	Belongs to the universal ribosomal protein uS2 family
LAG74_16260	COG0024	Methionine aminopeptidase
LAG74_16270	COG2171	N-acyltransferase activity
LAG74_16280	COG1263	PTS System
LAG74_16280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_16290	COG4580	involved in the transport of maltose and maltodextrins
LAG74_16300	COG0564	pseudouridine synthase activity
LAG74_16305	COG3098	single-species biofilm formation
LAG74_16330	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
LAG74_16340	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LAG74_16340	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LAG74_16355	COG1611	Belongs to the LOG family
LAG74_16360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAG74_16365	COG0473	3-isopropylmalate dehydrogenase activity
LAG74_16375	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LAG74_16380	COG2363	Small membrane protein
LAG74_16390	COG0583	DNA-binding transcription factor activity
LAG74_16395	COG0840	transmembrane signaling receptor activity
LAG74_16400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAG74_16415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LAG74_16420	COG1666	GTP binding
LAG74_16425	COG3248	Nucleoside-binding outer membrane protein
LAG74_16430	COG2211	Major facilitator Superfamily
LAG74_16435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LAG74_16445	COG2813	Specifically methylates the guanine in position
LAG74_16450	COG0271	Belongs to the BolA IbaG family
LAG74_16455	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LAG74_16460	COG1805	sodium ion transport
LAG74_16465	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LAG74_16470	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LAG74_16475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
LAG74_16480	COG2871	sodium ion transport
LAG74_16485	COG1477	protein flavinylation
LAG74_16515	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LAG74_16530	COG0300	oxidoreductase activity
LAG74_16540	COG0415	Belongs to the DNA photolyase family
LAG74_16545	COG0789	Transcriptional regulator
LAG74_16550	COG3272	Protein of unknown function (DUF1722)
LAG74_16580	COG1605	Chorismate mutase
LAG74_16580	COG0077	Prephenate dehydratase
LAG74_16615	COG1486	melibiose metabolic process
LAG74_16625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAG74_16630	COG2723	6-phospho-beta-galactosidase activity
LAG74_16635	COG1447	Phosphotransferase system cellobiose-specific component IIA
LAG74_16640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LAG74_16645	COG1609	Transcriptional regulator
LAG74_16660	COG5377	YqaJ viral recombinase family
LAG74_16705	COG2003	Belongs to the UPF0758 family
LAG74_16715	COG1518	maintenance of DNA repeat elements
LAG74_16760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LAG74_16805	COG0300	oxidoreductase activity
LAG74_16830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
LAG74_16870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LAG74_16875	COG0826	peptidase U32
LAG74_16880	COG1280	lysine exporter protein (LysE YggA)
LAG74_16890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LAG74_16900	COG0745	RESPONSE REGULATOR receiver
LAG74_16910	COG0643	Histidine kinase
LAG74_16910	COG2198	Histidine kinase
LAG74_16920	COG0835	chemotaxis
LAG74_16925	COG0840	transmembrane signaling receptor activity
LAG74_16935	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LAG74_16940	COG2201	protein-glutamate methylesterase activity
LAG74_16945	COG1185	polyribonucleotide nucleotidyltransferase activity
LAG74_16950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LAG74_16955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LAG74_16960	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LAG74_16965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LAG74_16970	COG0195	Participates in both transcription termination and antitermination
LAG74_16975	COG0779	Required for maturation of 30S ribosomal subunits
LAG74_16990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LAG74_16995	COG0149	triose-phosphate isomerase activity
LAG74_17000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LAG74_17005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LAG74_17015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LAG74_17020	COG1534	Rna-binding protein
LAG74_17035	COG1360	Flagellar Motor Protein
LAG74_17040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LAG74_17045	COG1722	exodeoxyribonuclease VII activity
LAG74_17050	COG0142	geranyltranstransferase activity
LAG74_17055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LAG74_17060	COG0737	Belongs to the 5'-nucleotidase family
LAG74_17080	COG2204	response regulator
LAG74_17085	COG0545	Peptidyl-prolyl cis-trans isomerase
LAG74_17095	COG2900	Belongs to the SlyX family
LAG74_17105	COG0601	transmembrane transport
LAG74_17120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LAG74_17125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LAG74_17130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAG74_17135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LAG74_17150	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAG74_17150	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LAG74_17155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LAG74_17160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LAG74_17170	COG0784	Response regulator, receiver
LAG74_17170	COG2198	Histidine kinase
LAG74_17170	COG2205	protein histidine kinase activity
LAG74_17175	COG1879	ABC-type sugar transport system periplasmic component
LAG74_17185	COG0745	RESPONSE REGULATOR receiver
LAG74_17190	COG3005	denitrification pathway
LAG74_17200	COG3381	protein complex oligomerization
LAG74_17220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LAG74_17225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LAG74_17230	COG0511	ligase activity, forming carbon-carbon bonds
LAG74_17235	COG0439	Biotin carboxylase
LAG74_17245	COG4145	pantothenate transmembrane transporter activity
LAG74_17250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_17250	COG1263	PTS System
LAG74_17250	COG2190	(PTS) system
LAG74_17255	COG0583	DNA-binding transcription factor activity
LAG74_17260	COG0604	alcohol dehydrogenase
LAG74_17265	COG2264	protein methyltransferase activity
LAG74_17270	COG0110	maltose O-acetyltransferase activity
LAG74_17275	COG0778	Nitroreductase
LAG74_17280	COG1902	pentaerythritol trinitrate reductase activity
LAG74_17280	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAG74_17285	COG0616	signal peptide processing
LAG74_17305	COG0848	biopolymer transport protein
LAG74_17310	COG0811	peptide transport
LAG74_17315	COG0811	peptide transport
LAG74_17325	COG4206	TonB-dependent receptor
LAG74_17330	COG4174	ABC transporter (Permease)
LAG74_17335	COG4239	(ABC) transporter, permease
LAG74_17345	COG0444	Belongs to the ABC transporter superfamily
LAG74_17350	COG4608	Belongs to the ABC transporter superfamily
LAG74_17370	COG3416	Protein conserved in bacteria
LAG74_17380	COG0741	lytic transglycosylase activity
LAG74_17395	COG0488	(ABC) transporter
LAG74_17405	COG2252	PERMEase
LAG74_17410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LAG74_17415	COG0840	transmembrane signaling receptor activity
LAG74_17425	COG1278	Cold shock
LAG74_17465	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LAG74_17475	COG0688	phosphatidylethanolamine metabolic process
LAG74_17480	COG4628	conserved protein (DUF2132)
LAG74_17495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LAG74_17510	COG1073	alpha beta
LAG74_17515	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LAG74_17520	COG2195	Cleaves the N-terminal amino acid of tripeptides
LAG74_17525	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LAG74_17530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LAG74_17535	COG3178	'Phosphotransferase
LAG74_17540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LAG74_17545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LAG74_17550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LAG74_17555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LAG74_17560	COG2967	ApaG domain
LAG74_17565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LAG74_17580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LAG74_17590	COG3314	Sporulation integral membrane protein YlbJ
LAG74_17595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LAG74_17600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LAG74_17605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LAG74_17610	COG0142	geranyltranstransferase activity
LAG74_17615	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LAG74_17620	COG0330	HflC and HflK could
LAG74_17625	COG0330	HflC and HflK could
LAG74_17630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LAG74_17635	COG1923	regulation of RNA biosynthetic process
LAG74_17640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LAG74_17645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LAG74_17650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LAG74_17660	COG0802	atpase or kinase
LAG74_17665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LAG74_17665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LAG74_17685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LAG74_17690	COG2011	ABC-type metal ion transport system permease component
LAG74_17695	COG1464	Belongs to the NlpA lipoprotein family
LAG74_17730	COG5002	protein histidine kinase activity
LAG74_17730	COG0784	Response regulator, receiver
LAG74_17730	COG2198	Histidine kinase
LAG74_17765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LAG74_17770	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LAG74_17775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LAG74_17780	COG2716	regulation of RNA biosynthetic process
LAG74_17785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LAG74_17790	COG3013	Belongs to the UPF0304 family
LAG74_17800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LAG74_17805	COG0280	phosphate acetyltransferase
LAG74_17805	COG0857	belongs to the CobB CobQ family
LAG74_17810	COG1555	photosystem II stabilization
LAG74_17815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LAG74_17820	COG3104	oligopeptide transport
LAG74_17825	COG0745	RESPONSE REGULATOR receiver
LAG74_17855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LAG74_17870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LAG74_17885	COG0440	acetolactate synthase activity
LAG74_17890	COG0028	Belongs to the TPP enzyme family
LAG74_17915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LAG74_17920	COG0473	3-isopropylmalate dehydrogenase activity
LAG74_17925	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LAG74_17930	COG0066	3-isopropylmalate dehydratase activity
LAG74_17945	COG4143	(ABC) transporter
LAG74_17950	COG1178	ABC-type Fe3 transport system permease component
LAG74_17955	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LAG74_17960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LAG74_18010	COG0459	protein refolding
LAG74_18015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LAG74_18020	COG0534	Mate efflux family protein
LAG74_18025	COG3030	protein affecting phage T7 exclusion by the F plasmid
LAG74_18030	COG1027	Aspartate ammonia-lyase
LAG74_18035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LAG74_18040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LAG74_18045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LAG74_18050	COG1610	YqeY-like protein
LAG74_18060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LAG74_18080	COG0151	Belongs to the GarS family
LAG74_18085	COG0138	bifunctional purine biosynthesis protein purh
LAG74_18095	COG3036	rescue of stalled ribosome
LAG74_18105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LAG74_18110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LAG74_18120	COG0673	inositol 2-dehydrogenase activity
LAG74_18130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LAG74_18135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LAG74_18145	COG0583	DNA-binding transcription factor activity
LAG74_18150	COG0477	Major facilitator Superfamily
LAG74_18165	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_18175	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LAG74_18190	COG0456	acetyltransferase
LAG74_18200	COG1022	Amp-dependent synthetase and ligase
LAG74_18210	COG2918	glutathione biosynthetic process
LAG74_18215	COG0612	Peptidase, M16
LAG74_18220	COG1238	metal cluster binding
LAG74_18225	COG1064	alcohol dehydrogenase
LAG74_18250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LAG74_18255	COG0359	binds to the 23S rRNA
LAG74_18260	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LAG74_18265	COG0360	Binds together with S18 to 16S ribosomal RNA
LAG74_18270	COG1914	H( )-stimulated, divalent metal cation uptake system
LAG74_18275	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LAG74_18285	COG0776	regulation of translation
LAG74_18300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LAG74_18315	COG0560	Phosphoserine phosphatase
LAG74_18325	COG0813	purine-nucleoside phosphorylase activity
LAG74_18330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LAG74_18335	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LAG74_18340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LAG74_18350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAG74_18355	COG0084	hydrolase, TatD family'
LAG74_18360	COG2165	general secretion pathway protein
LAG74_18365	COG1854	S-ribosylhomocysteine lyase activity
LAG74_18380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LAG74_18380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LAG74_18425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LAG74_18430	COG1047	Peptidyl-prolyl cis-trans
LAG74_18435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LAG74_18440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LAG74_18445	COG0196	riboflavin kinase activity
LAG74_18450	COG0728	peptidoglycan biosynthetic process
LAG74_18455	COG0268	Binds directly to 16S ribosomal RNA
LAG74_18460	COG0640	Transcriptional regulator
LAG74_18465	COG0583	DNA-binding transcription factor activity
LAG74_18475	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LAG74_18480	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LAG74_18485	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LAG74_18495	COG1051	belongs to the nudix hydrolase family
LAG74_18500	COG3066	DNA modification
LAG74_18510	COG0335	large ribosomal subunit rRNA binding
LAG74_18515	COG0336	Belongs to the RNA methyltransferase TrmD family
LAG74_18520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LAG74_18525	COG0228	four-way junction DNA binding
LAG74_18530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LAG74_18535	COG4137	Cytochrome C assembly protein
LAG74_18540	COG4536	flavin adenine dinucleotide binding
LAG74_18550	COG1017	nitric oxide dioxygenase activity
LAG74_18550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LAG74_18555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
LAG74_18560	COG0039	L-malate dehydrogenase activity
LAG74_18565	COG4160	amino acid transport
LAG74_18570	COG4215	(ABC) transporter
LAG74_18575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_18580	COG1126	abc transporter atp-binding protein
LAG74_18585	COG1438	arginine binding
LAG74_18590	COG2837	iron assimilation
LAG74_18595	COG3842	ATPase activity
LAG74_18605	COG1840	ABC-type Fe3 transport system, periplasmic component
LAG74_18610	COG0347	Belongs to the P(II) protein family
LAG74_18630	COG3022	response to hydroperoxide
LAG74_18645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LAG74_18650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LAG74_18655	COG0762	integral membrane protein
LAG74_18660	COG1872	DUF167
LAG74_18670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LAG74_18675	COG0583	DNA-binding transcription factor activity
LAG74_18690	COG1929	Belongs to the glycerate kinase type-1 family
LAG74_18695	COG2610	gluconate transmembrane transporter activity
LAG74_18700	COG3835	regulator
LAG74_18705	COG3112	Uncharacterised protein family (UPF0231)
LAG74_18725	COG3568	Endonuclease Exonuclease Phosphatase
LAG74_18735	COG0513	Belongs to the DEAD box helicase family
LAG74_18775	COG1448	Aminotransferase
LAG74_18790	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LAG74_18795	COG1328	CTP reductase activity
LAG74_18820	COG0543	2 iron, 2 sulfur cluster binding
LAG74_18820	COG0633	Ferredoxin
LAG74_18835	COG1215	transferase activity, transferring glycosyl groups
LAG74_18840	COG1649	PFAM Uncharacterised BCR, COG1649
LAG74_18840	COG0726	polysaccharide deacetylase
LAG74_18860	COG3397	chitin binding
LAG74_18865	COG3174	membrane
LAG74_18870	COG0110	maltose O-acetyltransferase activity
LAG74_18885	COG1011	Hydrolase
LAG74_18890	COG0494	nUDIX hydrolase
LAG74_18895	COG1218	3'(2'),5'-bisphosphate nucleotidase
LAG74_18900	COG0814	amino acid
LAG74_18905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAG74_18920	COG0626	cystathionine gamma-synthase activity
LAG74_18925	COG0460	homoserine dehydrogenase
LAG74_18925	COG0527	aspartate kinase activity
LAG74_18930	COG0306	phosphate transporter
LAG74_18935	COG1392	Phosphate transport regulator
LAG74_18945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LAG74_18950	COG2813	Specifically methylates the guanine in position
LAG74_18955	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LAG74_18960	COG0297	glycogen (starch) synthase activity
LAG74_19000	COG1757	Na H antiporter
LAG74_19005	COG0316	Belongs to the HesB IscA family
LAG74_19015	COG0038	chloride channel
LAG74_19020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LAG74_19035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAG74_19035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LAG74_19065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LAG74_19070	COG0564	pseudouridine synthase activity
LAG74_19080	COG0110	maltose O-acetyltransferase activity
LAG74_19085	COG0366	Alpha amylase catalytic
LAG74_19090	COG1263	PTS System
LAG74_19090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_19110	COG0252	asparaginase activity
LAG74_19120	COG1253	flavin adenine dinucleotide binding
LAG74_19125	COG0586	Pfam SNARE associated Golgi protein
LAG74_19130	COG1686	Belongs to the peptidase S11 family
LAG74_19165	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LAG74_19170	COG0527	aspartate kinase activity
LAG74_19175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LAG74_19185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LAG74_19190	COG1546	Belongs to the CinA family
LAG74_19195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LAG74_19200	COG4667	esterase of the alpha-beta hydrolase superfamily
LAG74_19210	COG1346	cytolysis
LAG74_19215	COG1380	Effector of murein hydrolase LrgA
LAG74_19220	COG0583	DNA-binding transcription factor activity
LAG74_19230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LAG74_19250	COG1943	Transposase
LAG74_19255	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LAG74_19260	COG2022	thiamine diphosphate biosynthetic process
LAG74_19270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LAG74_19275	COG0352	thiamine-phosphate diphosphorylase activity
LAG74_19280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LAG74_19300	COG0745	RESPONSE REGULATOR receiver
LAG74_19305	COG0642	Histidine kinase
LAG74_19310	COG0189	ligase activity
LAG74_19355	COG0477	Major facilitator Superfamily
LAG74_19370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LAG74_19375	COG1263	PTS System
LAG74_19375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LAG74_19380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
LAG74_19385	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LAG74_19395	COG0312	modulator of DNA gyrase
LAG74_19400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LAG74_19410	COG3164	Protein of unknown function
LAG74_19415	COG1530	ribonuclease E activity
LAG74_19420	COG0424	maF-like protein
LAG74_19425	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LAG74_19430	COG1792	Involved in formation and maintenance of cell shape
LAG74_19435	COG1077	Cell shape determining protein MreB Mrl
LAG74_19460	COG4968	Prepilin-type N-terminal cleavage methylation domain
LAG74_19480	COG1459	type II secretion system
LAG74_19485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LAG74_19530	COG2200	EAL domain
LAG74_19530	COG2199	diguanylate cyclase activity
LAG74_19535	COG2200	EAL domain
LAG74_19545	COG0387	Pfam Sodium calcium exchanger
LAG74_19550	COG2986	histidine ammonia-lyase
LAG74_19555	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LAG74_19560	COG0010	Belongs to the arginase family
LAG74_19565	COG1228	amidohydrolase
LAG74_19570	COG2188	Transcriptional regulator
LAG74_19575	COG0288	reversible hydration of carbon dioxide
LAG74_19585	COG2177	Part of the ABC transporter FtsEX involved in
LAG74_19590	COG2884	Cell division ATP-binding protein ftsE
LAG74_19595	COG0552	protein localization to endoplasmic reticulum
LAG74_19600	COG0742	ribosomal rna small subunit methyltransferase
LAG74_19625	COG2249	NAD(P)H dehydrogenase (quinone) activity
LAG74_19630	COG0583	DNA-binding transcription factor activity
LAG74_19635	COG4221	oxidoreductase activity
LAG74_19650	COG1770	oligopeptidase
LAG74_19665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LAG74_19675	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LAG74_19685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LAG74_19695	COG2095	MarC family integral membrane protein
LAG74_19705	COG1301	dicarboxylic acid transport
LAG74_19730	COG3714	YhhN family
LAG74_19785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LAG74_19790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAG74_19795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LAG74_19800	COG0049	tRNA binding
LAG74_19805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LAG74_19810	COG2168	tRNA wobble position uridine thiolation
LAG74_19815	COG2923	Belongs to the DsrF TusC family
LAG74_19820	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LAG74_19830	COG2964	Protein conserved in bacteria
LAG74_19835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LAG74_19840	COG0085	RNA polymerase activity
LAG74_19845	COG0222	ribosome binding
LAG74_19850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LAG74_19855	COG0081	regulation of translation
LAG74_19860	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LAG74_19865	COG0250	Participates in transcription elongation, termination and antitermination
LAG74_19880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LAG74_19905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LAG74_19910	COG0569	domain protein
LAG74_19915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LAG74_19945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LAG74_19945	COG4191	Histidine kinase
LAG74_19950	COG3005	denitrification pathway
LAG74_19955	COG0243	molybdopterin cofactor binding
LAG74_19990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LAG74_20000	COG2204	response regulator
LAG74_20010	COG2205	protein histidine kinase activity
LAG74_20025	COG1028	Short-chain dehydrogenase reductase Sdr
LAG74_20030	COG0516	GMP reductase activity
LAG74_20030	COG0517	IMP dehydrogenase activity
LAG74_20035	COG5413	integral membrane protein
LAG74_20045	COG1522	sequence-specific DNA binding
LAG74_20050	COG2502	aspartate--ammonia ligase
LAG74_20055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LAG74_20060	COG0542	response to heat
LAG74_20070	COG0564	pseudouridine synthase activity
LAG74_20075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LAG74_20080	COG0446	pyridine nucleotide-disulphide oxidoreductase
LAG74_20090	COG3681	Belongs to the UPF0597 family
LAG74_20095	COG2964	Protein conserved in bacteria
LAG74_20105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LAG74_20110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LAG74_20115	COG1979	alcohol dehydrogenase
LAG74_20120	COG2207	Transcriptional regulator
LAG74_20125	COG3040	lipid binding
LAG74_20140	COG0583	DNA-binding transcription factor activity
LAG74_20160	COG0540	Belongs to the ATCase OTCase family
LAG74_20165	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LAG74_20170	COG0531	amino acid
LAG74_20175	COG1982	Orn Lys Arg decarboxylase major
LAG74_20185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LAG74_20215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LAG74_20225	COG3078	GTPase activator activity
LAG74_20235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LAG74_20245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LAG74_20250	COG0408	coproporphyrinogen oxidase activity
LAG74_20255	COG0009	L-threonylcarbamoyladenylate synthase
LAG74_20265	COG0551	DNA topoisomerase type I activity
LAG74_20270	COG2922	Belongs to the Smg family
LAG74_20275	COG0758	DNA mediated transformation
LAG74_20280	COG1652	LysM domain
LAG74_20285	COG0242	peptide deformylase activity
LAG74_20290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LAG74_20295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LAG74_20295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LAG74_20300	COG0569	domain protein
LAG74_20305	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LAG74_20310	COG1217	gtp-binding protein TYPA
LAG74_20315	COG0174	glutamine synthetase
LAG74_20330	COG2204	response regulator
LAG74_20335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LAG74_20360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LAG74_20365	COG0583	DNA-binding transcription factor activity
LAG74_20370	COG0519	Catalyzes the synthesis of GMP from XMP
LAG74_20370	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LAG74_20380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LAG74_20385	COG1396	sequence-specific DNA binding
LAG74_20390	COG1012	belongs to the aldehyde dehydrogenase family
LAG74_20400	COG2962	Rard protein
LAG74_20405	COG0840	transmembrane signaling receptor activity
LAG74_20410	COG2391	methyltransferase activity
LAG74_20425	COG0129	dihydroxy-acid dehydratase activity
LAG74_20435	COG3978	acetolactate synthase activity
LAG74_20445	COG0606	chelatase, subunit chli
LAG74_20450	COG0204	Acyl-transferase
LAG74_20455	COG0204	Acyl-transferase
LAG74_20460	COG1683	Conserved Protein
LAG74_20470	COG1335	isochorismatase
LAG74_20480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAG74_20485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LAG74_20495	COG3084	Protein conserved in bacteria
LAG74_20500	COG2203	Gaf domain
LAG74_20500	COG3706	GGDEF domain
LAG74_20500	COG4251	negative regulation of phosphorylation
LAG74_20500	COG5001	Diguanylate cyclase
LAG74_20515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LAG74_20520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LAG74_20525	COG1561	YicC-like family, N-terminal region
LAG74_20570	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LAG74_20585	COG0583	DNA-binding transcription factor activity
LAG74_20605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LAG74_20610	COG0385	Bile acid
LAG74_20615	COG0531	amino acid
LAG74_20620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LAG74_20625	COG0531	amino acid
LAG74_20630	COG2731	YhcH YjgK YiaL family protein
LAG74_20635	COG3250	beta-galactosidase activity
LAG74_20640	COG1609	Transcriptional regulator
LAG74_20675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LAG74_20680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAG74_20680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LAG74_20685	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LAG74_20690	COG3074	FtsZ-dependent cytokinesis
LAG74_20700	COG1045	serine acetyltransferase
LAG74_20710	COG0745	RESPONSE REGULATOR receiver
LAG74_20715	COG2205	protein histidine kinase activity
LAG74_20720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LAG74_20725	COG0534	Mate efflux family protein
LAG74_20740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LAG74_20745	COG2937	Belongs to the GPAT DAPAT family
LAG74_20750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LAG74_20755	COG3161	chorismate lyase activity
LAG74_20775	COG0604	alcohol dehydrogenase
LAG74_20780	COG1609	Transcriptional regulator
LAG74_20785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LAG74_20800	COG1519	Transferase
LAG74_20805	COG0859	PFAM glycosyl transferase family 9
LAG74_20810	COG0463	Glycosyl transferase, family 2
LAG74_20815	COG0859	PFAM glycosyl transferase family 9
LAG74_20820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LAG74_20825	COG2990	Protein conserved in bacteria
LAG74_20830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LAG74_20840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LAG74_20845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LAG74_20850	COG2003	Belongs to the UPF0758 family
LAG74_20855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LAG74_20860	COG0756	dUTP diphosphatase activity
LAG74_20865	COG1309	transcriptional regulator
LAG74_20870	COG0668	transmembrane transport
LAG74_20875	COG0166	Belongs to the GPI family
LAG74_20880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LAG74_20900	COG0045	succinate-CoA ligase (ADP-forming) activity
LAG74_20900	COG1042	CoA-binding domain protein
LAG74_20900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LAG74_20930	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
LAG74_20935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LAG74_20940	COG1739	Uncharacterized protein family UPF0029
LAG74_20945	COG0006	proline dipeptidase activity
LAG74_20950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LAG74_20955	COG1024	Enoyl-CoA hydratase
LAG74_20955	COG1250	3-hydroxyacyl-CoA dehydrogenase
LAG74_20960	COG0183	Belongs to the thiolase family
LAG74_20985	COG0425	Belongs to the sulfur carrier protein TusA family
LAG74_20990	COG0251	oxidation-reduction process
LAG74_20995	COG2885	chlorophyll binding
LAG74_21000	COG2818	Glycosylase
LAG74_21005	COG0752	glycyl-tRNA synthetase alpha subunit
LAG74_21010	COG0751	glycine-tRNA ligase activity
LAG74_21040	COG1609	Transcriptional regulator
LAG74_21070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LAG74_21085	COG2960	long-chain fatty acid transporting porin activity
LAG74_21090	COG5001	Diguanylate cyclase
LAG74_21100	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LAG74_21115	COG3118	belongs to the thioredoxin family
LAG74_21120	COG0513	Belongs to the DEAD box helicase family
LAG74_21125	COG0248	Ppx GppA phosphatase
LAG74_21135	COG0742	ribosomal rna small subunit methyltransferase
LAG74_21150	COG3469	chitinase activity
LAG74_21155	COG3397	chitin binding
LAG74_21165	COG0084	hydrolase, TatD family'
LAG74_21170	COG0805	protein transport
LAG74_21175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LAG74_21185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LAG74_21190	COG3165	ubiquinone biosynthetic process from chorismate
LAG74_21195	COG2226	methyltransferase
LAG74_21200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LAG74_21205	COG0402	S-adenosylhomocysteine deaminase activity
LAG74_21210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LAG74_21250	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LAG74_21255	COG0848	biopolymer transport protein
LAG74_21260	COG0811	peptide transport
LAG74_21265	COG0811	peptide transport
LAG74_21275	COG2771	luxR family
LAG74_21280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LAG74_21285	COG1349	DNA-binding transcription factor activity
LAG74_21290	COG0745	RESPONSE REGULATOR receiver
LAG74_21295	COG2205	protein histidine kinase activity
LAG74_21310	COG4452	Inner membrane protein CreD
LAG74_21325	COG0297	glycogen (starch) synthase activity
LAG74_21325	COG0438	transferase activity, transferring glycosyl groups
LAG74_21330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LAG74_21370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LAG74_21375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LAG74_21380	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LAG74_21385	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LAG74_21390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LAG74_21395	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LAG74_21400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LAG74_21405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LAG74_21415	COG0356	it plays a direct role in the translocation of protons across the membrane
LAG74_21425	COG1475	DNA binding
LAG74_21430	COG1192	Involved in chromosome partitioning
LAG74_21435	COG0357	Ribosomal RNA small subunit methyltransferase G
LAG74_21440	COG0445	tRNA wobble uridine modification
LAG74_21445	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LAG74_21455	COG4615	Cyclic peptide transporter
LAG74_21460	COG1120	ATPase activity
LAG74_21465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LAG74_21470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LAG74_21475	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LAG74_21480	COG0706	membrane insertase activity
LAG74_21485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LAG74_21490	COG0594	ribonuclease P activity
LAG74_21495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LAG74_21500	COG1126	abc transporter atp-binding protein
LAG74_21565	COG0616	signal peptide processing
LAG74_21600	COG1525	nuclease
LAG74_21640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LAG74_21725	COG1192	Involved in chromosome partitioning
LAG74_21810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LAG74_21905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LAG74_21965	COG0714	Associated with various cellular activities
LAG74_22020	COG0633	Ferredoxin
LAG74_22160	COG4974	Belongs to the 'phage' integrase family
LAG74_22170	COG3550	peptidyl-serine autophosphorylation
LAG74_22285	COG1695	Transcriptional regulator
LAG74_22310	COG3173	Aminoglycoside phosphotransferase
LAG74_22330	COG4974	Belongs to the 'phage' integrase family