locus-tag	class	description
WP2S18C03_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP2S18C03_00020	COG0592	DNA-directed DNA polymerase activity
WP2S18C03_00070	COG2378	regulation of single-species biofilm formation
WP2S18C03_00090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2S18C03_00100	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2S18C03_00120	COG1484	DNA-dependent DNA replication
WP2S18C03_00130	COG4584	PFAM Integrase catalytic
WP2S18C03_00140	COG0071	Belongs to the small heat shock protein (HSP20) family
WP2S18C03_00150	COG3977	Valine--pyruvate aminotransferase
WP2S18C03_00170	COG2814	Major facilitator Superfamily
WP2S18C03_00180	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_00190	COG2205	protein histidine kinase activity
WP2S18C03_00230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2S18C03_00240	COG4191	Histidine kinase
WP2S18C03_00240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2S18C03_00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_00270	COG1309	transcriptional regulator
WP2S18C03_00290	COG1484	DNA-dependent DNA replication
WP2S18C03_00300	COG4584	PFAM Integrase catalytic
WP2S18C03_00330	COG0561	phosphatase activity
WP2S18C03_00340	COG2267	carboxylic ester hydrolase activity
WP2S18C03_00360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2S18C03_00370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2S18C03_00380	COG1758	RNA polymerase activity
WP2S18C03_00400	COG0859	PFAM glycosyl transferase family 9
WP2S18C03_00410	COG3642	lipopolysaccharide core region biosynthetic process
WP2S18C03_00490	COG0589	response to stress
WP2S18C03_00500	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP2S18C03_00510	COG1528	Iron-storage protein
WP2S18C03_00520	COG2081	HI0933 family
WP2S18C03_00530	COG3275	phosphorelay sensor kinase activity
WP2S18C03_00540	COG3279	Response regulator of the LytR AlgR family
WP2S18C03_00550	COG2223	nitrite transmembrane transporter activity
WP2S18C03_00560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP2S18C03_00570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP2S18C03_00600	COG0583	DNA-binding transcription factor activity
WP2S18C03_00620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WP2S18C03_00650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP2S18C03_00660	COG2166	iron-sulfur cluster assembly
WP2S18C03_00670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP2S18C03_00700	COG3245	cytochrome
WP2S18C03_00710	COG1063	alcohol dehydrogenase
WP2S18C03_00720	COG0156	8-amino-7-oxononanoate synthase activity
WP2S18C03_00740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2S18C03_00780	COG0438	transferase activity, transferring glycosyl groups
WP2S18C03_00790	COG3306	glycosyltransferase involved in LPS biosynthesis
WP2S18C03_00850	COG1280	lysine exporter protein (LysE YggA)
WP2S18C03_00910	COG1943	Transposase
WP2S18C03_00920	COG1943	Transposase
WP2S18C03_00950	COG0210	DNA helicase
WP2S18C03_01000	COG2239	Acts as a magnesium transporter
WP2S18C03_01010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2S18C03_01010	COG1648	precorrin-2 dehydrogenase activity
WP2S18C03_01020	COG2116	formate transmembrane transporter activity
WP2S18C03_01040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2S18C03_01050	COG0842	Transport permease protein
WP2S18C03_01060	COG0842	Transport permease protein
WP2S18C03_01070	COG1131	(ABC) transporter
WP2S18C03_01080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_01120	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP2S18C03_01130	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP2S18C03_01150	COG0018	arginyl-trna synthetase
WP2S18C03_01170	COG1595	DNA-templated transcription, initiation
WP2S18C03_01190	COG1968	undecaprenyl-diphosphatase activity
WP2S18C03_01200	COG2017	converts alpha-aldose to the beta-anomer
WP2S18C03_01210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP2S18C03_01220	COG1085	galactose-1-phosphate uridylyltransferase
WP2S18C03_01230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2S18C03_01240	COG1609	Transcriptional regulator
WP2S18C03_01250	COG3250	beta-galactosidase activity
WP2S18C03_01300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2S18C03_01330	COG0366	Alpha amylase catalytic
WP2S18C03_01360	COG0443	Heat shock 70 kDa protein
WP2S18C03_01370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2S18C03_01380	COG3045	CreA protein
WP2S18C03_01420	COG0174	glutamine synthetase
WP2S18C03_01460	COG3842	ATPase activity
WP2S18C03_01470	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2S18C03_01480	COG1177	transmembrane transport
WP2S18C03_01490	COG2258	MOSC domain
WP2S18C03_01510	COG2050	protein possibly involved in aromatic compounds catabolism
WP2S18C03_01520	COG0514	ATP-dependent DNA helicase (RecQ)
WP2S18C03_01540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP2S18C03_01560	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP2S18C03_01590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2S18C03_01620	COG0254	rRNA binding
WP2S18C03_01630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP2S18C03_01650	COG0702	epimerase
WP2S18C03_01660	COG0814	amino acid
WP2S18C03_01670	COG0281	malic enzyme
WP2S18C03_01680	COG1295	ribonuclease BN
WP2S18C03_01690	COG1490	D-aminoacyl-tRNA deacylase activity
WP2S18C03_01700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WP2S18C03_01720	COG0456	acetyltransferase
WP2S18C03_01740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP2S18C03_01750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2S18C03_01760	COG2610	gluconate transmembrane transporter activity
WP2S18C03_01770	COG3265	gluconokinase activity
WP2S18C03_01790	COG0800	Aldolase
WP2S18C03_01800	COG2207	Transcriptional regulator
WP2S18C03_01820	COG1609	Transcriptional regulator
WP2S18C03_01840	COG4942	peptidase
WP2S18C03_01850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP2S18C03_01860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2S18C03_01870	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP2S18C03_01880	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP2S18C03_01890	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP2S18C03_01890	COG0316	Belongs to the HesB IscA family
WP2S18C03_01900	COG1040	competence protein
WP2S18C03_01910	COG0596	Alpha beta hydrolase
WP2S18C03_01950	COG2183	response to ionizing radiation
WP2S18C03_01960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2S18C03_02000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2S18C03_02030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2S18C03_02040	COG1484	DNA-dependent DNA replication
WP2S18C03_02050	COG4584	PFAM Integrase catalytic
WP2S18C03_02120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2S18C03_02130	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_02160	COG0051	transcription antitermination factor activity, RNA binding
WP2S18C03_02170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP2S18C03_02180	COG0088	Forms part of the polypeptide exit tunnel
WP2S18C03_02190	COG0089	rRNA binding
WP2S18C03_02200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP2S18C03_02210	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP2S18C03_02220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP2S18C03_02230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP2S18C03_02240	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP2S18C03_02250	COG0255	Belongs to the universal ribosomal protein uL29 family
WP2S18C03_02260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP2S18C03_02270	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP2S18C03_02280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP2S18C03_02290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP2S18C03_02300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP2S18C03_02310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP2S18C03_02320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP2S18C03_02330	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WP2S18C03_02340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP2S18C03_02350	COG1841	ribosomal large subunit assembly
WP2S18C03_02360	COG0200	Binds to the 23S rRNA
WP2S18C03_02370	COG0201	protein transport
WP2S18C03_02380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP2S18C03_02390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP2S18C03_02400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP2S18C03_02410	COG0202	RNA polymerase activity
WP2S18C03_02420	COG0203	ribosomal protein L17
WP2S18C03_02440	COG4771	TonB-dependent receptor
WP2S18C03_02450	COG4584	PFAM Integrase catalytic
WP2S18C03_02460	COG1484	DNA-dependent DNA replication
WP2S18C03_02470	COG4771	TonB-dependent receptor
WP2S18C03_02480	COG3706	GGDEF domain
WP2S18C03_02500	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_02530	COG0583	DNA-binding transcription factor activity
WP2S18C03_02550	COG1741	Belongs to the pirin family
WP2S18C03_02560	COG2259	Doxx family
WP2S18C03_02570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP2S18C03_02580	COG1074	ATP-dependent DNA helicase activity
WP2S18C03_02590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2S18C03_02630	COG2199	diguanylate cyclase activity
WP2S18C03_02630	COG2203	Gaf domain
WP2S18C03_02650	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2S18C03_02700	COG1175	transmembrane transport
WP2S18C03_02720	COG3842	ATPase activity
WP2S18C03_02780	COG2873	o-acetylhomoserine
WP2S18C03_02830	COG5380	lipid catabolic process
WP2S18C03_02840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP2S18C03_02850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2S18C03_02900	COG0456	acetyltransferase
WP2S18C03_02900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
WP2S18C03_02910	COG0456	acetyltransferase
WP2S18C03_02910	COG0454	-acetyltransferase
WP2S18C03_02960	COG2927	DNA polymerase III (CHI subunit)
WP2S18C03_02970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2S18C03_02980	COG0795	lipopolysaccharide-transporting ATPase activity
WP2S18C03_02990	COG0795	lipopolysaccharide-transporting ATPase activity
WP2S18C03_03000	COG3385	transposase activity
WP2S18C03_03010	COG3385	transposase activity
WP2S18C03_03280	COG4695	Portal protein
WP2S18C03_03500	COG4974	Belongs to the 'phage' integrase family
WP2S18C03_03510	COG0582	viral genome integration into host DNA
WP2S18C03_03630	COG5002	protein histidine kinase activity
WP2S18C03_03630	COG2176	DNA-directed DNA polymerase activity
WP2S18C03_03670	COG1484	DNA-dependent DNA replication
WP2S18C03_03680	COG4584	PFAM Integrase catalytic
WP2S18C03_03720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP2S18C03_03730	COG1288	antiporter activity
WP2S18C03_03740	COG3385	transposase activity
WP2S18C03_03750	COG3385	transposase activity
WP2S18C03_03760	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2S18C03_03770	COG0564	pseudouridine synthase activity
WP2S18C03_03790	COG0542	response to heat
WP2S18C03_03800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP2S18C03_03810	COG2502	aspartate--ammonia ligase
WP2S18C03_03820	COG1522	sequence-specific DNA binding
WP2S18C03_03840	COG5413	integral membrane protein
WP2S18C03_03880	COG2205	protein histidine kinase activity
WP2S18C03_03900	COG2204	response regulator
WP2S18C03_03940	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
WP2S18C03_03970	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_03980	COG2205	protein histidine kinase activity
WP2S18C03_04000	COG0243	molybdopterin cofactor binding
WP2S18C03_04010	COG3005	denitrification pathway
WP2S18C03_04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_04020	COG4191	Histidine kinase
WP2S18C03_04040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP2S18C03_04050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2S18C03_04060	COG0569	domain protein
WP2S18C03_04070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP2S18C03_04100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2S18C03_04120	COG0250	Participates in transcription elongation, termination and antitermination
WP2S18C03_04130	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP2S18C03_04140	COG0081	regulation of translation
WP2S18C03_04150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP2S18C03_04160	COG0222	ribosome binding
WP2S18C03_04170	COG0085	RNA polymerase activity
WP2S18C03_04180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP2S18C03_04190	COG2964	Protein conserved in bacteria
WP2S18C03_04210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2S18C03_04220	COG2923	Belongs to the DsrF TusC family
WP2S18C03_04230	COG2168	tRNA wobble position uridine thiolation
WP2S18C03_04240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP2S18C03_04250	COG0049	tRNA binding
WP2S18C03_04260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP2S18C03_04270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP2S18C03_04280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2S18C03_04330	COG3714	YhhN family
WP2S18C03_04380	COG1301	dicarboxylic acid transport
WP2S18C03_04400	COG2095	MarC family integral membrane protein
WP2S18C03_04420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2S18C03_04440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2S18C03_04460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP2S18C03_04490	COG1770	oligopeptidase
WP2S18C03_04520	COG4221	oxidoreductase activity
WP2S18C03_04530	COG0583	DNA-binding transcription factor activity
WP2S18C03_04540	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2S18C03_04590	COG0742	ribosomal rna small subunit methyltransferase
WP2S18C03_04600	COG0552	protein localization to endoplasmic reticulum
WP2S18C03_04610	COG2884	Cell division ATP-binding protein ftsE
WP2S18C03_04620	COG2177	Part of the ABC transporter FtsEX involved in
WP2S18C03_04640	COG0288	reversible hydration of carbon dioxide
WP2S18C03_04650	COG2188	Transcriptional regulator
WP2S18C03_04660	COG1228	amidohydrolase
WP2S18C03_04670	COG0010	Belongs to the arginase family
WP2S18C03_04680	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP2S18C03_04690	COG2986	histidine ammonia-lyase
WP2S18C03_04700	COG0387	Pfam Sodium calcium exchanger
WP2S18C03_04720	COG2200	EAL domain
WP2S18C03_04730	COG2200	EAL domain
WP2S18C03_04730	COG2199	diguanylate cyclase activity
WP2S18C03_04820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2S18C03_04830	COG1459	type II secretion system
WP2S18C03_04860	COG4969	Belongs to the N-Me-Phe pilin family
WP2S18C03_04870	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2S18C03_04940	COG1077	Cell shape determining protein MreB Mrl
WP2S18C03_04950	COG1792	Involved in formation and maintenance of cell shape
WP2S18C03_04960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP2S18C03_04970	COG0424	maF-like protein
WP2S18C03_04980	COG1530	ribonuclease E activity
WP2S18C03_04990	COG3164	Protein of unknown function
WP2S18C03_05010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2S18C03_05020	COG0312	modulator of DNA gyrase
WP2S18C03_05040	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
WP2S18C03_05050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WP2S18C03_05060	COG1263	PTS System
WP2S18C03_05060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_05070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
WP2S18C03_05110	COG0477	Major facilitator Superfamily
WP2S18C03_05190	COG0646	methionine synthase
WP2S18C03_05190	COG1410	methionine synthase
WP2S18C03_05200	COG0189	ligase activity
WP2S18C03_05210	COG0642	Histidine kinase
WP2S18C03_05220	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_05260	COG0789	Transcriptional regulator
WP2S18C03_05270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP2S18C03_05280	COG0352	thiamine-phosphate diphosphorylase activity
WP2S18C03_05290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2S18C03_05310	COG2022	thiamine diphosphate biosynthetic process
WP2S18C03_05320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2S18C03_05360	COG0110	maltose O-acetyltransferase activity
WP2S18C03_05390	COG0814	amino acid
WP2S18C03_05400	COG3932	Exopolysaccharide synthesis, ExoD
WP2S18C03_05430	COG3706	GGDEF domain
WP2S18C03_05440	COG0004	ammonium transporteR
WP2S18C03_05450	COG3133	Outer membrane lipoprotein
WP2S18C03_05460	COG0456	acetyltransferase
WP2S18C03_05520	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP2S18C03_05550	COG0494	nUDIX hydrolase
WP2S18C03_05560	COG0628	permease
WP2S18C03_05600	COG3284	Transcriptional regulator
WP2S18C03_05620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP2S18C03_05620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_05620	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
WP2S18C03_05630	COG1461	Dihydroxyacetone kinase
WP2S18C03_05640	COG2376	Dihydroxyacetone kinase
WP2S18C03_05660	COG2252	PERMEase
WP2S18C03_05800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP2S18C03_05880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP2S18C03_05910	COG3047	cAMP biosynthetic process
WP2S18C03_05920	COG0840	transmembrane signaling receptor activity
WP2S18C03_05970	COG3135	benzoate transporter
WP2S18C03_05980	COG1396	sequence-specific DNA binding
WP2S18C03_06010	COG4584	PFAM Integrase catalytic
WP2S18C03_06020	COG1484	DNA-dependent DNA replication
WP2S18C03_06030	COG4584	PFAM Integrase catalytic
WP2S18C03_06040	COG1484	DNA-dependent DNA replication
WP2S18C03_06070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2S18C03_06070	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2S18C03_06070	COG1042	CoA-binding domain protein
WP2S18C03_06120	COG2194	sulfuric ester hydrolase activity
WP2S18C03_06170	COG0789	Transcriptional regulator
WP2S18C03_06200	COG0672	)-iron permease
WP2S18C03_06210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_06260	COG3300	MHYT domain
WP2S18C03_06260	COG5001	Diguanylate cyclase
WP2S18C03_06410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2S18C03_06420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2S18C03_06430	COG2801	Transposase and inactivated derivatives
WP2S18C03_06490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP2S18C03_06500	COG0038	chloride channel
WP2S18C03_06520	COG0316	Belongs to the HesB IscA family
WP2S18C03_06540	COG1757	Na H antiporter
WP2S18C03_06570	COG1484	DNA-dependent DNA replication
WP2S18C03_06580	COG4584	PFAM Integrase catalytic
WP2S18C03_06600	COG0297	glycogen (starch) synthase activity
WP2S18C03_06610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP2S18C03_06620	COG2813	Specifically methylates the guanine in position
WP2S18C03_06630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2S18C03_06640	COG3025	triphosphatase activity
WP2S18C03_06650	COG1392	Phosphate transport regulator
WP2S18C03_06660	COG0306	phosphate transporter
WP2S18C03_06670	COG0460	homoserine dehydrogenase
WP2S18C03_06670	COG0527	aspartate kinase activity
WP2S18C03_06680	COG0626	cystathionine gamma-synthase activity
WP2S18C03_06710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2S18C03_06720	COG0814	amino acid
WP2S18C03_06730	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP2S18C03_06740	COG0494	nUDIX hydrolase
WP2S18C03_06750	COG1011	Hydrolase
WP2S18C03_06780	COG0110	maltose O-acetyltransferase activity
WP2S18C03_06790	COG3174	membrane
WP2S18C03_06800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP2S18C03_06820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP2S18C03_06830	COG4208	sulfate ABC transporter
WP2S18C03_06840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP2S18C03_06850	COG0583	DNA-binding transcription factor activity
WP2S18C03_06860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2S18C03_06870	COG0765	amino acid transport
WP2S18C03_06900	COG1126	abc transporter atp-binding protein
WP2S18C03_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_06920	COG3397	chitin binding
WP2S18C03_06930	COG0840	transmembrane signaling receptor activity
WP2S18C03_06960	COG0633	Ferredoxin
WP2S18C03_06960	COG0543	2 iron, 2 sulfur cluster binding
WP2S18C03_06990	COG1328	CTP reductase activity
WP2S18C03_07000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2S18C03_07030	COG1448	Aminotransferase
WP2S18C03_07130	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_07190	COG3112	Uncharacterised protein family (UPF0231)
WP2S18C03_07200	COG3835	regulator
WP2S18C03_07210	COG2610	gluconate transmembrane transporter activity
WP2S18C03_07220	COG1929	Belongs to the glycerate kinase type-1 family
WP2S18C03_07250	COG0583	DNA-binding transcription factor activity
WP2S18C03_07260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2S18C03_07280	COG1872	DUF167
WP2S18C03_07290	COG0762	integral membrane protein
WP2S18C03_07300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP2S18C03_07310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP2S18C03_07370	COG3022	response to hydroperoxide
WP2S18C03_07410	COG0347	Belongs to the P(II) protein family
WP2S18C03_07420	COG1840	ABC-type Fe3 transport system, periplasmic component
WP2S18C03_07440	COG3842	ATPase activity
WP2S18C03_07450	COG2837	iron assimilation
WP2S18C03_07460	COG1438	arginine binding
WP2S18C03_07470	COG1126	abc transporter atp-binding protein
WP2S18C03_07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_07490	COG4215	(ABC) transporter
WP2S18C03_07500	COG4160	amino acid transport
WP2S18C03_07510	COG0039	L-malate dehydrogenase activity
WP2S18C03_07520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP2S18C03_07530	COG1017	nitric oxide dioxygenase activity
WP2S18C03_07530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2S18C03_07550	COG4536	flavin adenine dinucleotide binding
WP2S18C03_07560	COG4137	Cytochrome C assembly protein
WP2S18C03_07570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP2S18C03_07580	COG0228	four-way junction DNA binding
WP2S18C03_07590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP2S18C03_07600	COG0336	Belongs to the RNA methyltransferase TrmD family
WP2S18C03_07610	COG0335	large ribosomal subunit rRNA binding
WP2S18C03_07640	COG1051	belongs to the nudix hydrolase family
WP2S18C03_07650	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
WP2S18C03_07660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP2S18C03_07670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP2S18C03_07680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2S18C03_07700	COG0583	DNA-binding transcription factor activity
WP2S18C03_07710	COG0640	Transcriptional regulator
WP2S18C03_07720	COG0268	Binds directly to 16S ribosomal RNA
WP2S18C03_07730	COG0728	peptidoglycan biosynthetic process
WP2S18C03_07740	COG0196	riboflavin kinase activity
WP2S18C03_07750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP2S18C03_07760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP2S18C03_07770	COG1047	Peptidyl-prolyl cis-trans
WP2S18C03_07780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP2S18C03_07850	COG4584	PFAM Integrase catalytic
WP2S18C03_07860	COG1484	DNA-dependent DNA replication
WP2S18C03_07940	COG4969	Belongs to the N-Me-Phe pilin family
WP2S18C03_07950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP2S18C03_07950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP2S18C03_07980	COG1854	S-ribosylhomocysteine lyase activity
WP2S18C03_07990	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP2S18C03_08000	COG0084	hydrolase, TatD family'
WP2S18C03_08010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2S18C03_08030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP2S18C03_08040	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP2S18C03_08050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP2S18C03_08060	COG0813	purine-nucleoside phosphorylase activity
WP2S18C03_08080	COG0560	Phosphoserine phosphatase
WP2S18C03_08110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP2S18C03_08130	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
WP2S18C03_08140	COG0776	regulation of translation
WP2S18C03_08170	COG1914	H( )-stimulated, divalent metal cation uptake system
WP2S18C03_08180	COG0360	Binds together with S18 to 16S ribosomal RNA
WP2S18C03_08190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP2S18C03_08200	COG0359	binds to the 23S rRNA
WP2S18C03_08210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2S18C03_08260	COG4221	oxidoreductase activity
WP2S18C03_08260	COG3321	synthase
WP2S18C03_08260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2S18C03_08260	COG0604	alcohol dehydrogenase
WP2S18C03_08270	COG1238	metal cluster binding
WP2S18C03_08280	COG0612	Peptidase, M16
WP2S18C03_08290	COG2918	glutathione biosynthetic process
WP2S18C03_08300	COG1022	Amp-dependent synthetase and ligase
WP2S18C03_08310	COG0456	acetyltransferase
WP2S18C03_08340	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP2S18C03_08380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP2S18C03_08400	COG0477	Major facilitator Superfamily
WP2S18C03_08410	COG0583	DNA-binding transcription factor activity
WP2S18C03_08430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2S18C03_08440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP2S18C03_08460	COG0673	inositol 2-dehydrogenase activity
WP2S18C03_08480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP2S18C03_08490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2S18C03_08500	COG3036	rescue of stalled ribosome
WP2S18C03_08520	COG0138	bifunctional purine biosynthesis protein purh
WP2S18C03_08530	COG0151	Belongs to the GarS family
WP2S18C03_08560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP2S18C03_08580	COG1610	YqeY-like protein
WP2S18C03_08590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP2S18C03_08600	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP2S18C03_08610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2S18C03_08620	COG1027	Aspartate ammonia-lyase
WP2S18C03_08630	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP2S18C03_08640	COG0534	Mate efflux family protein
WP2S18C03_08650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP2S18C03_08660	COG0459	protein refolding
WP2S18C03_08710	COG1484	DNA-dependent DNA replication
WP2S18C03_08720	COG4584	PFAM Integrase catalytic
WP2S18C03_08750	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP2S18C03_08760	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP2S18C03_08770	COG1178	ABC-type Fe3 transport system permease component
WP2S18C03_08810	COG0066	3-isopropylmalate dehydratase activity
WP2S18C03_08820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP2S18C03_08830	COG0473	3-isopropylmalate dehydrogenase activity
WP2S18C03_08840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP2S18C03_08890	COG0028	Belongs to the TPP enzyme family
WP2S18C03_08900	COG0440	acetolactate synthase activity
WP2S18C03_09000	COG3311	Transcriptional regulator
WP2S18C03_09090	COG4584	PFAM Integrase catalytic
WP2S18C03_09100	COG1484	DNA-dependent DNA replication
WP2S18C03_09120	COG2003	Belongs to the UPF0758 family
WP2S18C03_09220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP2S18C03_09230	COG0732	type I restriction modification DNA specificity domain
WP2S18C03_09240	COG1401	restriction endodeoxyribonuclease activity
WP2S18C03_09240	COG1401	restriction endodeoxyribonuclease activity
WP2S18C03_09260	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP2S18C03_09270	COG4584	PFAM Integrase catalytic
WP2S18C03_09280	COG1484	DNA-dependent DNA replication
WP2S18C03_09320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2S18C03_09360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP2S18C03_09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_09450	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_09460	COG3104	oligopeptide transport
WP2S18C03_09470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP2S18C03_09480	COG1555	photosystem II stabilization
WP2S18C03_09490	COG0280	phosphate acetyltransferase
WP2S18C03_09490	COG0857	belongs to the CobB CobQ family
WP2S18C03_09500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP2S18C03_09520	COG3013	Belongs to the UPF0304 family
WP2S18C03_09530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP2S18C03_09540	COG2716	regulation of RNA biosynthetic process
WP2S18C03_09550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP2S18C03_09560	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP2S18C03_09570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP2S18C03_09640	COG2198	Histidine kinase
WP2S18C03_09640	COG5002	protein histidine kinase activity
WP2S18C03_09640	COG0784	Response regulator, receiver
WP2S18C03_09710	COG1464	Belongs to the NlpA lipoprotein family
WP2S18C03_09720	COG2011	ABC-type metal ion transport system permease component
WP2S18C03_09730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP2S18C03_09770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP2S18C03_09770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP2S18C03_09780	COG0802	atpase or kinase
WP2S18C03_09800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP2S18C03_09810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP2S18C03_09820	COG1923	regulation of RNA biosynthetic process
WP2S18C03_09830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP2S18C03_09840	COG0330	HflC and HflK could
WP2S18C03_09850	COG0330	HflC and HflK could
WP2S18C03_09860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP2S18C03_09870	COG0142	geranyltranstransferase activity
WP2S18C03_09880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP2S18C03_09890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP2S18C03_09900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP2S18C03_09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP2S18C03_09940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP2S18C03_09950	COG2967	ApaG domain
WP2S18C03_09960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP2S18C03_09970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP2S18C03_09980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2S18C03_09990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP2S18C03_10000	COG3178	'Phosphotransferase
WP2S18C03_10010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP2S18C03_10020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2S18C03_10030	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2S18C03_10050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP2S18C03_10110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP2S18C03_10140	COG4628	conserved protein (DUF2132)
WP2S18C03_10150	COG0688	phosphatidylethanolamine metabolic process
WP2S18C03_10160	COG1162	GTPase activity
WP2S18C03_10170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP2S18C03_10180	COG1278	Cold shock
WP2S18C03_10200	COG0840	transmembrane signaling receptor activity
WP2S18C03_10210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2S18C03_10220	COG2252	PERMEase
WP2S18C03_10240	COG0488	(ABC) transporter
WP2S18C03_10270	COG0741	lytic transglycosylase activity
WP2S18C03_10290	COG3416	Protein conserved in bacteria
WP2S18C03_10330	COG4608	Belongs to the ABC transporter superfamily
WP2S18C03_10340	COG0444	Belongs to the ABC transporter superfamily
WP2S18C03_10350	COG4239	(ABC) transporter, permease
WP2S18C03_10360	COG4174	ABC transporter (Permease)
WP2S18C03_10380	COG0616	signal peptide processing
WP2S18C03_10390	COG1902	pentaerythritol trinitrate reductase activity
WP2S18C03_10390	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2S18C03_10400	COG0778	Nitroreductase
WP2S18C03_10420	COG2264	protein methyltransferase activity
WP2S18C03_10430	COG0604	alcohol dehydrogenase
WP2S18C03_10440	COG0583	DNA-binding transcription factor activity
WP2S18C03_10450	COG1263	PTS System
WP2S18C03_10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_10450	COG2190	(PTS) system
WP2S18C03_10460	COG4145	pantothenate transmembrane transporter activity
WP2S18C03_10470	COG3924	membrane
WP2S18C03_10480	COG0439	Biotin carboxylase
WP2S18C03_10490	COG0511	ligase activity, forming carbon-carbon bonds
WP2S18C03_10500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP2S18C03_10510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2S18C03_10550	COG3381	protein complex oligomerization
WP2S18C03_10580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP2S18C03_10600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP2S18C03_10610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2S18C03_10610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP2S18C03_10650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2S18C03_10660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP2S18C03_10670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP2S18C03_10700	COG4166	transmembrane transport
WP2S18C03_10730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP2S18C03_10740	COG0142	geranyltranstransferase activity
WP2S18C03_10750	COG1722	exodeoxyribonuclease VII activity
WP2S18C03_10760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2S18C03_10770	COG1360	Flagellar Motor Protein
WP2S18C03_10770	COG1360	Flagellar Motor Protein
WP2S18C03_10800	COG1534	Rna-binding protein
WP2S18C03_10810	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP2S18C03_10830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP2S18C03_10840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP2S18C03_10850	COG0149	triose-phosphate isomerase activity
WP2S18C03_10860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP2S18C03_10870	COG0779	Required for maturation of 30S ribosomal subunits
WP2S18C03_10880	COG0195	Participates in both transcription termination and antitermination
WP2S18C03_10890	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP2S18C03_10900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP2S18C03_10910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP2S18C03_10920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP2S18C03_10930	COG1185	polyribonucleotide nucleotidyltransferase activity
WP2S18C03_10940	COG2201	protein-glutamate methylesterase activity
WP2S18C03_10950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WP2S18C03_10970	COG0840	transmembrane signaling receptor activity
WP2S18C03_11000	COG0835	chemotaxis
WP2S18C03_11010	COG0840	transmembrane signaling receptor activity
WP2S18C03_11020	COG2963	transposase activity
WP2S18C03_11030	COG4584	PFAM Integrase catalytic
WP2S18C03_11040	COG1484	DNA-dependent DNA replication
WP2S18C03_11050	COG2801	Transposase and inactivated derivatives
WP2S18C03_11090	COG0643	Histidine kinase
WP2S18C03_11090	COG2198	Histidine kinase
WP2S18C03_11110	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_11120	COG0840	transmembrane signaling receptor activity
WP2S18C03_11130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP2S18C03_11150	COG1280	lysine exporter protein (LysE YggA)
WP2S18C03_11160	COG0826	peptidase U32
WP2S18C03_11170	COG0737	Belongs to the 5'-nucleotidase family
WP2S18C03_11180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP2S18C03_11210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP2S18C03_11260	COG0300	oxidoreductase activity
WP2S18C03_11330	COG0077	Prephenate dehydratase
WP2S18C03_11330	COG1605	Chorismate mutase
WP2S18C03_11390	COG3272	Protein of unknown function (DUF1722)
WP2S18C03_11400	COG0789	Transcriptional regulator
WP2S18C03_11410	COG0415	Belongs to the DNA photolyase family
WP2S18C03_11430	COG0300	oxidoreductase activity
WP2S18C03_11460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2S18C03_11520	COG1477	protein flavinylation
WP2S18C03_11530	COG2871	sodium ion transport
WP2S18C03_11540	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2S18C03_11550	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2S18C03_11560	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2S18C03_11570	COG1805	sodium ion transport
WP2S18C03_11580	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP2S18C03_11590	COG0271	Belongs to the BolA IbaG family
WP2S18C03_11600	COG2813	Specifically methylates the guanine in position
WP2S18C03_11620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2S18C03_11640	COG3248	Nucleoside-binding outer membrane protein
WP2S18C03_11650	COG1666	GTP binding
WP2S18C03_11660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP2S18C03_11690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP2S18C03_11700	COG0840	transmembrane signaling receptor activity
WP2S18C03_11710	COG0583	DNA-binding transcription factor activity
WP2S18C03_11730	COG2363	Small membrane protein
WP2S18C03_11740	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP2S18C03_11760	COG0473	3-isopropylmalate dehydrogenase activity
WP2S18C03_11770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2S18C03_11780	COG1611	Belongs to the LOG family
WP2S18C03_11790	COG3706	GGDEF domain
WP2S18C03_11810	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2S18C03_11810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP2S18C03_11830	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP2S18C03_11890	COG3098	single-species biofilm formation
WP2S18C03_11900	COG0564	pseudouridine synthase activity
WP2S18C03_11940	COG1263	PTS System
WP2S18C03_11940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_11960	COG2171	N-acyltransferase activity
WP2S18C03_11980	COG0024	Methionine aminopeptidase
WP2S18C03_11990	COG0052	Belongs to the universal ribosomal protein uS2 family
WP2S18C03_12000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP2S18C03_12010	COG0528	UMP kinase activity
WP2S18C03_12020	COG0233	cytoplasmic translational termination
WP2S18C03_12030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP2S18C03_12040	COG0575	Belongs to the CDS family
WP2S18C03_12050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP2S18C03_12060	COG0750	zinc metalloprotease
WP2S18C03_12070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2S18C03_12090	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2S18C03_12100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2S18C03_12110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2S18C03_12120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2S18C03_12130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP2S18C03_12150	COG0825	malonyl-CoA metabolic process
WP2S18C03_12170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP2S18C03_12180	COG1115	amino acid carrier protein
WP2S18C03_12190	COG4584	PFAM Integrase catalytic
WP2S18C03_12200	COG1484	DNA-dependent DNA replication
WP2S18C03_12230	COG0714	Associated with various cellular activities
WP2S18C03_12280	COG3104	oligopeptide transport
WP2S18C03_12290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP2S18C03_12300	COG1678	Uncharacterized ACR, COG1678
WP2S18C03_12320	COG0189	ligase activity
WP2S18C03_12330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP2S18C03_12350	COG3091	SprT-like family
WP2S18C03_12370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP2S18C03_12420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP2S18C03_12430	COG0739	heme binding
WP2S18C03_12440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP2S18C03_12510	COG0814	amino acid
WP2S18C03_12550	COG0531	amino acid
WP2S18C03_12560	COG3710	Transcriptional regulator
WP2S18C03_12570	COG0531	amino acid
WP2S18C03_12580	COG1982	Orn Lys Arg decarboxylase major
WP2S18C03_12590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP2S18C03_12610	COG3590	peptidase
WP2S18C03_12630	COG2199	diguanylate cyclase activity
WP2S18C03_12630	COG2203	Gaf domain
WP2S18C03_12700	COG0366	Alpha amylase catalytic
WP2S18C03_12730	COG0463	Glycosyl transferase, family 2
WP2S18C03_12750	COG2989	Protein conserved in bacteria
WP2S18C03_12760	COG3108	Peptidase M15
WP2S18C03_12780	COG2860	membrane
WP2S18C03_12800	COG1196	nuclear chromosome segregation
WP2S18C03_12810	COG3115	cell septum assembly
WP2S18C03_12820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP2S18C03_12840	COG1328	CTP reductase activity
WP2S18C03_12850	COG0602	queuosine metabolic process
WP2S18C03_12940	COG0281	malic enzyme
WP2S18C03_12950	COG3290	protein histidine kinase activity
WP2S18C03_12970	COG0697	spore germination
WP2S18C03_12990	COG3706	GGDEF domain
WP2S18C03_13000	COG0346	lactoylglutathione lyase activity
WP2S18C03_13010	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_13020	COG5002	protein histidine kinase activity
WP2S18C03_13080	COG3142	Participates in the control of copper homeostasis
WP2S18C03_13090	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2S18C03_13120	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
WP2S18C03_13160	COG0019	diaminopimelate decarboxylase activity
WP2S18C03_13170	COG1115	amino acid carrier protein
WP2S18C03_13180	COG2233	PERMEase
WP2S18C03_13190	COG3706	GGDEF domain
WP2S18C03_13210	COG0534	Mate efflux family protein
WP2S18C03_13230	COG0281	malic enzyme
WP2S18C03_13300	COG0733	neurotransmitter:sodium symporter activity
WP2S18C03_13320	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2S18C03_13330	COG3706	GGDEF domain
WP2S18C03_13350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2S18C03_13360	COG1032	radical SAM domain protein
WP2S18C03_13430	COG0673	inositol 2-dehydrogenase activity
WP2S18C03_13440	COG2920	part of a sulfur-relay system
WP2S18C03_13450	COG1289	transmembrane transporter activity
WP2S18C03_13460	COG0670	Belongs to the BI1 family
WP2S18C03_13480	COG1486	melibiose metabolic process
WP2S18C03_13490	COG2169	Transcriptional regulator
WP2S18C03_13490	COG1917	Cupin 2, conserved barrel domain protein
WP2S18C03_13500	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP2S18C03_13510	COG2723	6-phospho-beta-galactosidase activity
WP2S18C03_13520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2S18C03_13530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP2S18C03_13550	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP2S18C03_13570	COG3156	type II secretion system protein K
WP2S18C03_13580	COG4795	General secretion pathway protein
WP2S18C03_13590	COG2165	general secretion pathway protein
WP2S18C03_13610	COG2165	general secretion pathway protein
WP2S18C03_13620	COG1459	type II secretion system
WP2S18C03_13630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2S18C03_13640	COG1450	Type ii and iii secretion system protein
WP2S18C03_13670	COG3409	Peptidoglycan-binding domain 1 protein
WP2S18C03_13670	COG3267	Type II secretory pathway component ExeA
WP2S18C03_13680	COG2770	Histidine kinase
WP2S18C03_13680	COG3437	response regulator, receiver
WP2S18C03_13710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP2S18C03_13720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP2S18C03_13730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_13750	COG2190	(PTS) system
WP2S18C03_13760	COG3706	GGDEF domain
WP2S18C03_13770	COG3264	Mechanosensitive ion channel
WP2S18C03_13770	COG1196	nuclear chromosome segregation
WP2S18C03_13780	COG0469	pyruvate kinase activity
WP2S18C03_13800	COG3384	dioxygenase
WP2S18C03_13810	COG0419	ATPase involved in DNA repair
WP2S18C03_13820	COG0420	3'-5' exonuclease activity
WP2S18C03_13840	COG2974	May be involved in recombination
WP2S18C03_13860	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP2S18C03_13880	COG0531	amino acid
WP2S18C03_13900	COG0531	amino acid
WP2S18C03_13930	COG1396	sequence-specific DNA binding
WP2S18C03_13930	COG1917	Cupin 2, conserved barrel domain protein
WP2S18C03_13940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_14000	COG3152	Membrane
WP2S18C03_14010	COG3161	chorismate lyase activity
WP2S18C03_14030	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_14060	COG1720	tRNA m6t6A37 methyltransferase activity
WP2S18C03_14100	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP2S18C03_14110	COG4988	ABC transporter
WP2S18C03_14120	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_14140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP2S18C03_14170	COG0640	Transcriptional regulator
WP2S18C03_14200	COG0798	PFAM Bile acid sodium symporter
WP2S18C03_14230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2S18C03_14240	COG3550	peptidyl-serine autophosphorylation
WP2S18C03_14250	COG1396	sequence-specific DNA binding
WP2S18C03_14260	COG1988	membrane-bound metal-dependent
WP2S18C03_14290	COG0159	tryptophan synthase activity
WP2S18C03_14300	COG0133	tryptophan synthase activity
WP2S18C03_14310	COG0135	phosphoribosylanthranilate isomerase activity
WP2S18C03_14310	COG0134	indole-3-glycerol-phosphate synthase activity
WP2S18C03_14320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2S18C03_14330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP2S18C03_14330	COG0512	Glutamine amidotransferase of anthranilate synthase
WP2S18C03_14340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP2S18C03_14360	COG0009	L-threonylcarbamoyladenylate synthase
WP2S18C03_14380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP2S18C03_14400	COG1993	acr, cog1993
WP2S18C03_14410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP2S18C03_14430	COG1946	Acyl-CoA thioesterase
WP2S18C03_14440	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP2S18C03_14450	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP2S18C03_14470	COG0083	homoserine kinase activity
WP2S18C03_14480	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP2S18C03_14490	COG3039	Transposase
WP2S18C03_14500	COG1484	DNA-dependent DNA replication
WP2S18C03_14510	COG4584	PFAM Integrase catalytic
WP2S18C03_14520	COG1943	Transposase
WP2S18C03_14540	COG4584	PFAM Integrase catalytic
WP2S18C03_14550	COG1484	DNA-dependent DNA replication
WP2S18C03_14560	COG0675	Transposase, IS605 OrfB family
WP2S18C03_14580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2S18C03_14620	COG1342	Belongs to the UPF0251 family
WP2S18C03_14650	COG1309	transcriptional regulator
WP2S18C03_14660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_14670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2S18C03_14690	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP2S18C03_14760	COG0367	asparagine synthase
WP2S18C03_14780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
WP2S18C03_14820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP2S18C03_14850	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP2S18C03_14870	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP2S18C03_14880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP2S18C03_14900	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WP2S18C03_14920	COG1484	DNA-dependent DNA replication
WP2S18C03_14930	COG4584	PFAM Integrase catalytic
WP2S18C03_14980	COG1136	(ABC) transporter
WP2S18C03_14980	COG0577	efflux transmembrane transporter activity
WP2S18C03_14990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_15000	COG1227	inorganic diphosphatase activity
WP2S18C03_15010	COG0497	DNA recombination
WP2S18C03_15020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP2S18C03_15030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP2S18C03_15040	COG0443	Heat shock 70 kDa protein
WP2S18C03_15050	COG0484	heat shock protein binding
WP2S18C03_15110	COG1285	pathogenesis
WP2S18C03_15130	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2S18C03_15200	COG5001	Diguanylate cyclase
WP2S18C03_15210	COG0095	Lipoate-protein ligase
WP2S18C03_15230	COG0702	epimerase
WP2S18C03_15240	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2S18C03_15250	COG4584	PFAM Integrase catalytic
WP2S18C03_15260	COG4584	PFAM Integrase catalytic
WP2S18C03_15270	COG1484	DNA-dependent DNA replication
WP2S18C03_15280	COG1454	alcohol dehydrogenase
WP2S18C03_15300	COG0564	pseudouridine synthase activity
WP2S18C03_15310	COG1957	nucleoside hydrolase
WP2S18C03_15360	COG1280	lysine exporter protein (LysE YggA)
WP2S18C03_15390	COG3263	regulation of cellular component size
WP2S18C03_15410	COG1876	peptidase activity
WP2S18C03_15420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP2S18C03_15430	COG1393	Belongs to the ArsC family
WP2S18C03_15450	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2S18C03_15460	COG1473	amidohydrolase
WP2S18C03_15480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP2S18C03_15500	COG0017	Asparaginyl-tRNA synthetase
WP2S18C03_15530	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WP2S18C03_15540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP2S18C03_15550	COG0156	8-amino-7-oxononanoate synthase activity
WP2S18C03_15560	COG1073	alpha beta
WP2S18C03_15560	COG2226	methyltransferase
WP2S18C03_15570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP2S18C03_15580	COG0501	Belongs to the peptidase M48B family
WP2S18C03_15590	COG3217	Mosc domain protein beta barrel domain protein
WP2S18C03_15590	COG0633	Ferredoxin
WP2S18C03_15590	COG0633	Ferredoxin
WP2S18C03_15590	COG3217	Mosc domain protein beta barrel domain protein
WP2S18C03_15620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP2S18C03_15620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP2S18C03_15620	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP2S18C03_15620	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP2S18C03_15640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP2S18C03_15650	COG1607	acyl-coa hydrolase
WP2S18C03_15670	COG3021	interspecies interaction between organisms
WP2S18C03_15680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP2S18C03_15690	COG2027	D-alanyl-D-alanine carboxypeptidase
WP2S18C03_15700	COG1061	Type III restriction enzyme res subunit
WP2S18C03_15710	COG1566	PFAM secretion protein HlyD family protein
WP2S18C03_15730	COG1966	Carbon starvation protein
WP2S18C03_15740	COG3279	Response regulator of the LytR AlgR family
WP2S18C03_15750	COG3275	phosphorelay sensor kinase activity
WP2S18C03_15760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2S18C03_15760	COG2199	diguanylate cyclase activity
WP2S18C03_15790	COG1940	carbohydrate kinase activity
WP2S18C03_15790	COG1846	Transcriptional regulator
WP2S18C03_15800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2S18C03_15810	COG0363	glucosamine-6-phosphate deaminase activity
WP2S18C03_15820	COG1263	PTS System
WP2S18C03_15820	COG2190	(PTS) system
WP2S18C03_15820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_15860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2S18C03_15870	COG0735	belongs to the Fur family
WP2S18C03_15890	COG0716	FMN binding
WP2S18C03_15920	COG0596	Alpha beta hydrolase
WP2S18C03_15930	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP2S18C03_15940	COG0033	Phosphoglucomutase
WP2S18C03_15950	COG2951	lytic endotransglycosylase activity
WP2S18C03_15960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP2S18C03_15970	COG4136	ATPase activity
WP2S18C03_15980	COG4135	transport system, permease component
WP2S18C03_15990	COG4134	Bacterial extracellular solute-binding protein
WP2S18C03_16000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2S18C03_16010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP2S18C03_16030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2S18C03_16050	COG0729	surface antigen
WP2S18C03_16060	COG2911	Protein conserved in bacteria
WP2S18C03_16080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP2S18C03_16100	COG0741	lytic transglycosylase activity
WP2S18C03_16120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2S18C03_16130	COG4771	TonB-dependent receptor
WP2S18C03_16140	COG1169	isochorismate synthase
WP2S18C03_16150	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP2S18C03_16160	COG1535	isochorismatase
WP2S18C03_16160	COG3433	isochorismatase activity
WP2S18C03_16170	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_16180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2S18C03_16180	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
WP2S18C03_16230	COG1278	Cold shock
WP2S18C03_16280	COG0747	negative chemotaxis
WP2S18C03_16290	COG0697	spore germination
WP2S18C03_16300	COG1349	DNA-binding transcription factor activity
WP2S18C03_16310	COG1882	Formate acetyltransferase
WP2S18C03_16320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2S18C03_16330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP2S18C03_16380	COG4166	transmembrane transport
WP2S18C03_16390	COG0622	Phosphoesterase
WP2S18C03_16420	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP2S18C03_16430	COG0835	chemotaxis
WP2S18C03_16430	COG0784	Response regulator, receiver
WP2S18C03_16440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP2S18C03_16450	COG1815	bacterial-type flagellum-dependent cell motility
WP2S18C03_16490	COG4787	bacterial-type flagellum-dependent cell motility
WP2S18C03_16510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP2S18C03_16520	COG1706	bacterial-type flagellum-dependent cell motility
WP2S18C03_16530	COG1705	Flagellar rod assembly protein muramidase FlgJ
WP2S18C03_16530	COG3951	Flagellar rod assembly protein muramidase FlgJ
WP2S18C03_16560	COG2239	Acts as a magnesium transporter
WP2S18C03_16580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP2S18C03_16590	COG2716	regulation of RNA biosynthetic process
WP2S18C03_16620	COG3852	Histidine kinase
WP2S18C03_16640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP2S18C03_16650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP2S18C03_16660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP2S18C03_16670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP2S18C03_16710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP2S18C03_16730	COG0590	tRNA wobble adenosine to inosine editing
WP2S18C03_16740	COG0573	inorganic phosphate transmembrane transporter activity
WP2S18C03_16750	COG0581	inorganic phosphate transmembrane transporter activity
WP2S18C03_16760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
WP2S18C03_16770	COG0704	Plays a role in the regulation of phosphate uptake
WP2S18C03_16780	COG1253	flavin adenine dinucleotide binding
WP2S18C03_16810	COG0531	amino acid
WP2S18C03_16820	COG4584	PFAM Integrase catalytic
WP2S18C03_16830	COG1484	DNA-dependent DNA replication
WP2S18C03_16840	COG0531	amino acid
WP2S18C03_16870	COG1126	abc transporter atp-binding protein
WP2S18C03_16880	COG0765	amino acid transport
WP2S18C03_16890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_16900	COG5001	Diguanylate cyclase
WP2S18C03_16900	COG3300	MHYT domain
WP2S18C03_16930	COG2197	response regulator
WP2S18C03_16940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP2S18C03_16990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP2S18C03_17000	COG0477	Major facilitator Superfamily
WP2S18C03_17010	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP2S18C03_17030	COG1199	ATP-dependent helicase activity
WP2S18C03_17050	COG0287	Prephenate dehydrogenase
WP2S18C03_17050	COG1605	Chorismate mutase
WP2S18C03_17060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2S18C03_17080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2S18C03_17090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2S18C03_17160	COG0537	adenosine 5'-monophosphoramidase activity
WP2S18C03_17170	COG0840	transmembrane signaling receptor activity
WP2S18C03_17190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP2S18C03_17210	COG1301	dicarboxylic acid transport
WP2S18C03_17230	COG2354	Protein conserved in bacteria
WP2S18C03_17240	COG1164	Oligoendopeptidase f
WP2S18C03_17250	COG2233	PERMEase
WP2S18C03_17260	COG3150	esterase
WP2S18C03_17270	COG1252	NADH dehydrogenase
WP2S18C03_17290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP2S18C03_17310	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2S18C03_17330	COG2373	Large extracellular alpha-helical protein
WP2S18C03_17340	COG4953	penicillin-binding protein 1C
WP2S18C03_17370	COG0301	tRNA thio-modification
WP2S18C03_17370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2S18C03_17490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP2S18C03_17510	COG2089	acid synthase
WP2S18C03_17530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WP2S18C03_17540	COG1083	cytidylyl-transferase
WP2S18C03_17560	COG1086	Polysaccharide biosynthesis protein
WP2S18C03_17570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP2S18C03_17590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP2S18C03_17620	COG0483	inositol monophosphate 1-phosphatase activity
WP2S18C03_17640	COG0625	glutathione transferase activity
WP2S18C03_17650	COG2814	Major facilitator Superfamily
WP2S18C03_17660	COG0583	DNA-binding transcription factor activity
WP2S18C03_17680	COG0243	molybdopterin cofactor binding
WP2S18C03_17710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2S18C03_17720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2S18C03_17730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP2S18C03_17740	COG0509	glycine decarboxylation via glycine cleavage system
WP2S18C03_17750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2S18C03_17750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP2S18C03_17760	COG0840	transmembrane signaling receptor activity
WP2S18C03_17770	COG0546	phosphoglycolate phosphatase activity
WP2S18C03_17820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP2S18C03_17830	COG0574	Belongs to the PEP-utilizing enzyme family
WP2S18C03_17830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP2S18C03_17860	COG1464	Belongs to the NlpA lipoprotein family
WP2S18C03_17870	COG3083	sulfuric ester hydrolase activity
WP2S18C03_17880	COG3082	Protein of unknown function (DUF1414)
WP2S18C03_17890	COG3081	Nucleoid-associated protein
WP2S18C03_17910	COG1175	transmembrane transport
WP2S18C03_17920	COG3833	ABC-type maltose transport systems, permease component
WP2S18C03_17930	COG3842	ATPase activity
WP2S18C03_17980	COG0425	Belongs to the sulfur carrier protein TusA family
WP2S18C03_17990	COG4783	chaperone-mediated protein folding
WP2S18C03_18010	COG1393	Belongs to the ArsC family
WP2S18C03_18040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP2S18C03_18050	COG2431	L-lysine efflux transmembrane transporter activity
WP2S18C03_18090	COG4160	amino acid transport
WP2S18C03_18140	COG0564	pseudouridine synthase activity
WP2S18C03_18170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP2S18C03_18190	COG0625	glutathione transferase activity
WP2S18C03_18200	COG0367	asparagine synthase
WP2S18C03_18220	COG4651	solute:proton antiporter activity
WP2S18C03_18220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP2S18C03_18230	COG0647	UMP catabolic process
WP2S18C03_18260	COG1902	pentaerythritol trinitrate reductase activity
WP2S18C03_18270	COG1253	flavin adenine dinucleotide binding
WP2S18C03_18290	COG0277	FAD linked oxidase domain protein
WP2S18C03_18290	COG0247	lactate metabolic process
WP2S18C03_18310	COG2050	protein possibly involved in aromatic compounds catabolism
WP2S18C03_18340	COG5001	Diguanylate cyclase
WP2S18C03_18340	COG3300	MHYT domain
WP2S18C03_18350	COG2056	Na+-H+ antiporter family
WP2S18C03_18360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2S18C03_18370	COG0671	phosphoesterase, PA-phosphatase related
WP2S18C03_18380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2S18C03_18390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2S18C03_18410	COG0101	tRNA pseudouridine synthase activity
WP2S18C03_18420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP2S18C03_18430	COG0285	dihydrofolate synthase activity
WP2S18C03_18440	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP2S18C03_18450	COG0393	Putative heavy-metal-binding
WP2S18C03_18470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2S18C03_18470	COG1648	precorrin-2 dehydrogenase activity
WP2S18C03_18520	COG1619	proteins homologs of microcin C7 resistance protein MccF
WP2S18C03_18530	COG1368	sulfuric ester hydrolase activity
WP2S18C03_18550	COG0527	aspartate kinase activity
WP2S18C03_18560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP2S18C03_18560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2S18C03_18570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2S18C03_18610	COG0596	Alpha beta hydrolase
WP2S18C03_18650	COG2814	Major facilitator Superfamily
WP2S18C03_18690	COG0672	)-iron permease
WP2S18C03_18850	COG4584	PFAM Integrase catalytic
WP2S18C03_18860	COG1484	DNA-dependent DNA replication
WP2S18C03_18870	COG0393	Putative heavy-metal-binding
WP2S18C03_18960	COG2963	transposase activity
WP2S18C03_19020	COG3706	GGDEF domain
WP2S18C03_19080	COG4584	PFAM Integrase catalytic
WP2S18C03_19090	COG1484	DNA-dependent DNA replication
WP2S18C03_19100	COG0582	viral genome integration into host DNA
WP2S18C03_19130	COG0659	secondary active sulfate transmembrane transporter activity
WP2S18C03_19160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP2S18C03_19180	COG0392	lysyltransferase activity
WP2S18C03_19180	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP2S18C03_19200	COG2205	protein histidine kinase activity
WP2S18C03_19210	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_19360	COG4584	PFAM Integrase catalytic
WP2S18C03_19370	COG1484	DNA-dependent DNA replication
WP2S18C03_19440	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP2S18C03_19450	COG1278	Cold shock
WP2S18C03_19460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP2S18C03_19470	COG0542	response to heat
WP2S18C03_19480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP2S18C03_19490	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP2S18C03_19500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP2S18C03_19510	COG3134	Outer membrane lipoprotein
WP2S18C03_19520	COG3706	GGDEF domain
WP2S18C03_19530	COG0492	ferredoxin-NADP+ reductase activity
WP2S18C03_19540	COG0686	Belongs to the AlaDH PNT family
WP2S18C03_19560	COG0531	amino acid
WP2S18C03_19560	COG1674	ftsk spoiiie
WP2S18C03_19570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP2S18C03_19580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP2S18C03_19590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP2S18C03_19600	COG1286	toxin biosynthetic process
WP2S18C03_19610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP2S18C03_19630	COG0563	adenylate kinase activity
WP2S18C03_19640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP2S18C03_19660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2S18C03_19690	COG5001	Diguanylate cyclase
WP2S18C03_19690	COG3300	MHYT domain
WP2S18C03_19800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP2S18C03_19810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2S18C03_19840	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_19850	COG0386	Belongs to the glutathione peroxidase family
WP2S18C03_19870	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP2S18C03_19880	COG0383	alpha-mannosidase activity
WP2S18C03_19890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_19890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_19890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_19900	COG2188	Transcriptional regulator
WP2S18C03_19910	COG1570	exodeoxyribonuclease VII activity
WP2S18C03_19960	COG0516	GMP reductase activity
WP2S18C03_19960	COG0517	IMP dehydrogenase activity
WP2S18C03_19970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2S18C03_19970	COG0519	Catalyzes the synthesis of GMP from XMP
WP2S18C03_20050	COG2062	phosphohistidine phosphatase, SixA
WP2S18C03_20070	COG0697	spore germination
WP2S18C03_20080	COG4166	transmembrane transport
WP2S18C03_20090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP2S18C03_20100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP2S18C03_20120	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2S18C03_20130	COG1136	(ABC) transporter
WP2S18C03_20140	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP2S18C03_20150	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP2S18C03_20170	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP2S18C03_20180	COG0740	serine-type endopeptidase activity
WP2S18C03_20190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP2S18C03_20200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2S18C03_20220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP2S18C03_20230	COG0488	(ABC) transporter
WP2S18C03_20240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2S18C03_20250	COG3162	membrane
WP2S18C03_20280	COG1024	Enoyl-CoA hydratase
WP2S18C03_20290	COG1115	amino acid carrier protein
WP2S18C03_20310	COG3228	Belongs to the MtfA family
WP2S18C03_20320	COG1584	GPR1 FUN34 yaaH family protein
WP2S18C03_20390	COG1024	Enoyl-CoA hydratase
WP2S18C03_20400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP2S18C03_20410	COG1960	acyl-CoA dehydrogenase activity
WP2S18C03_20420	COG1960	acyl-CoA dehydrogenase activity
WP2S18C03_20430	COG1024	Enoyl-CoA hydratase
WP2S18C03_20440	COG1024	Enoyl-CoA hydratase
WP2S18C03_20460	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_20480	COG0730	response to heat
WP2S18C03_20490	COG0582	viral genome integration into host DNA
WP2S18C03_20530	COG4584	PFAM Integrase catalytic
WP2S18C03_20540	COG1484	DNA-dependent DNA replication
WP2S18C03_20570	COG2003	Belongs to the UPF0758 family
WP2S18C03_20700	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP2S18C03_20710	COG0437	4 iron, 4 sulfur cluster binding
WP2S18C03_20720	COG5557	Pfam Polysulphide reductase, NrfD
WP2S18C03_20730	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP2S18C03_20740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP2S18C03_20750	COG1773	rubredoxin
WP2S18C03_20780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2S18C03_20790	COG0444	Belongs to the ABC transporter superfamily
WP2S18C03_20800	COG3842	ATPase activity
WP2S18C03_20810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP2S18C03_20830	COG0375	protein maturation
WP2S18C03_20840	COG0309	Hydrogenase expression formation protein (HypE)
WP2S18C03_20860	COG0298	carbon dioxide binding
WP2S18C03_20870	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP2S18C03_20890	COG1921	L-seryl-tRNASec selenium transferase activity
WP2S18C03_20900	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP2S18C03_20920	COG3260	NADH ubiquinone oxidoreductase 20
WP2S18C03_20930	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_20940	COG3261	NADH dehydrogenase
WP2S18C03_20940	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
WP2S18C03_20950	COG0650	Formate hydrogenlyase subunit 4
WP2S18C03_20960	COG0651	ATP synthesis coupled electron transport
WP2S18C03_20970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2S18C03_20980	COG3158	transport of potassium into the cell
WP2S18C03_20990	COG1196	nuclear chromosome segregation
WP2S18C03_21000	COG5433	transposase activity
WP2S18C03_21020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2S18C03_21070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP2S18C03_21080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_21090	COG3046	protein related to deoxyribodipyrimidine photolyase
WP2S18C03_21100	COG3033	Beta-eliminating lyase
WP2S18C03_21110	COG0295	cytidine deaminase activity
WP2S18C03_21120	COG1346	cytolysis
WP2S18C03_21130	COG1380	Effector of murein hydrolase LrgA
WP2S18C03_21140	COG3345	alpha-galactosidase
WP2S18C03_21160	COG2925	Exonuclease
WP2S18C03_21210	COG1484	DNA-dependent DNA replication
WP2S18C03_21220	COG4584	PFAM Integrase catalytic
WP2S18C03_21250	COG4235	cytochrome complex assembly
WP2S18C03_21250	COG3088	subunit of a heme lyase
WP2S18C03_21260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2S18C03_21270	COG1138	Cytochrome C-type biogenesis protein
WP2S18C03_21280	COG3301	Polysulphide reductase, NrfD
WP2S18C03_21290	COG0437	4 iron, 4 sulfur cluster binding
WP2S18C03_21300	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP2S18C03_21350	COG0247	lactate metabolic process
WP2S18C03_21360	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP2S18C03_21370	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP2S18C03_21390	COG3012	SEC-C Motif Domain Protein
WP2S18C03_21400	COG0840	transmembrane signaling receptor activity
WP2S18C03_21410	COG1846	Transcriptional regulator
WP2S18C03_21410	COG1940	carbohydrate kinase activity
WP2S18C03_21430	COG0730	response to heat
WP2S18C03_21440	COG0583	DNA-binding transcription factor activity
WP2S18C03_21480	COG3593	DNA synthesis involved in DNA repair
WP2S18C03_21510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2S18C03_21520	COG1011	Hydrolase
WP2S18C03_21550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2S18C03_21560	COG2832	Protein of unknown function (DUF454)
WP2S18C03_21570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP2S18C03_21590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP2S18C03_21640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP2S18C03_21660	COG0583	DNA-binding transcription factor activity
WP2S18C03_21680	COG1560	Kdo2-lipid A biosynthetic process
WP2S18C03_21690	COG1560	Kdo2-lipid A biosynthetic process
WP2S18C03_21730	COG0417	DNA replication proofreading
WP2S18C03_21760	COG1451	nucleotide metabolic process
WP2S18C03_21790	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2S18C03_21820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_21820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP2S18C03_21830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2S18C03_21840	COG2985	domain, Protein
WP2S18C03_21840	COG0569	domain protein
WP2S18C03_21850	COG0556	nucleotide-excision repair
WP2S18C03_21870	COG0586	Pfam SNARE associated Golgi protein
WP2S18C03_21880	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP2S18C03_21890	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP2S18C03_21950	COG0534	Mate efflux family protein
WP2S18C03_21980	COG0307	riboflavin synthase, alpha
WP2S18C03_22010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2S18C03_22020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP2S18C03_22030	COG0697	spore germination
WP2S18C03_22040	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP2S18C03_22120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2S18C03_22130	COG3099	Belongs to the UPF0263 family
WP2S18C03_22140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP2S18C03_22150	COG2894	cell division
WP2S18C03_22160	COG0850	regulation of cytokinetic process
WP2S18C03_22170	COG3100	YcgL domain-containing protein
WP2S18C03_22200	COG2824	Alkylphosphonate utilization operon protein PhnA
WP2S18C03_22240	COG0406	alpha-ribazole phosphatase activity
WP2S18C03_22250	COG3706	GGDEF domain
WP2S18C03_22260	COG2840	Smr protein MutS2
WP2S18C03_22270	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2S18C03_22280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP2S18C03_22300	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_22310	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP2S18C03_22340	COG0814	amino acid
WP2S18C03_22350	COG4584	PFAM Integrase catalytic
WP2S18C03_22360	COG1484	DNA-dependent DNA replication
WP2S18C03_22370	COG0814	amino acid
WP2S18C03_22380	COG1609	Transcriptional regulator
WP2S18C03_22390	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_22390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_22400	COG1105	Belongs to the carbohydrate kinase PfkB family
WP2S18C03_22410	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP2S18C03_22410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_22410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_22420	COG3313	Fe-S protein
WP2S18C03_22430	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP2S18C03_22440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2S18C03_22450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2S18C03_22460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP2S18C03_22480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2S18C03_22500	COG0366	Alpha amylase catalytic
WP2S18C03_22540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP2S18C03_22550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP2S18C03_22560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP2S18C03_22570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP2S18C03_22580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2S18C03_22590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP2S18C03_22600	COG0072	phenylalanine-tRNA ligase activity
WP2S18C03_22600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2S18C03_22610	COG0776	regulation of translation
WP2S18C03_22630	COG0784	Response regulator, receiver
WP2S18C03_22630	COG2205	protein histidine kinase activity
WP2S18C03_22670	COG1609	Transcriptional regulator
WP2S18C03_22680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2S18C03_22690	COG1879	ABC-type sugar transport system periplasmic component
WP2S18C03_22700	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP2S18C03_22710	COG1129	ABC transporter
WP2S18C03_22720	COG1869	D-ribose catabolic process
WP2S18C03_22730	COG0625	glutathione transferase activity
WP2S18C03_22780	COG1177	transmembrane transport
WP2S18C03_22830	COG0037	tRNA processing
WP2S18C03_22840	COG0589	response to stress
WP2S18C03_22850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2S18C03_22900	COG2010	Cytochrome c
WP2S18C03_22930	COG3278	Belongs to the heme-copper respiratory oxidase family
WP2S18C03_22950	COG1956	GAF domain-containing protein
WP2S18C03_22960	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP2S18C03_22980	COG0308	aminopeptidase N
WP2S18C03_23000	COG2902	Dehydrogenase
WP2S18C03_23010	COG0167	dihydroorotate dehydrogenase activity
WP2S18C03_23040	COG2203	Gaf domain
WP2S18C03_23040	COG3706	GGDEF domain
WP2S18C03_23040	COG4251	negative regulation of phosphorylation
WP2S18C03_23040	COG5001	Diguanylate cyclase
WP2S18C03_23050	COG2201	protein-glutamate methylesterase activity
WP2S18C03_23060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP2S18C03_23110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_23180	COG0835	chemotaxis
WP2S18C03_23190	COG0840	transmembrane signaling receptor activity
WP2S18C03_23260	COG0116	Belongs to the methyltransferase superfamily
WP2S18C03_23260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2S18C03_23300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2S18C03_23310	COG1067	ATP-dependent peptidase activity
WP2S18C03_23350	COG1484	DNA-dependent DNA replication
WP2S18C03_23360	COG4584	PFAM Integrase catalytic
WP2S18C03_23380	COG3141	response to X-ray
WP2S18C03_23400	COG4221	oxidoreductase activity
WP2S18C03_23450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP2S18C03_23490	COG0372	Belongs to the citrate synthase family
WP2S18C03_23500	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP2S18C03_23520	COG2995	paraquat-inducible protein a
WP2S18C03_23530	COG3008	intermembrane lipid transfer
WP2S18C03_23540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2S18C03_23540	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP2S18C03_23580	COG4644	lycopene metabolic process
WP2S18C03_23590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2S18C03_23590	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP2S18C03_23620	COG0084	hydrolase, TatD family'
WP2S18C03_23630	COG0470	DNA polymerase III
WP2S18C03_23640	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP2S18C03_23650	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP2S18C03_23660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP2S18C03_23680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP2S18C03_23690	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_23710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP2S18C03_23720	COG0416	fatty acid biosynthetic process
WP2S18C03_23730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP2S18C03_23740	COG1399	metal-binding, possibly nucleic acid-binding protein
WP2S18C03_23750	COG0424	maF-like protein
WP2S18C03_23790	COG1530	ribonuclease E activity
WP2S18C03_23800	COG0306	phosphate transporter
WP2S18C03_23810	COG0717	Belongs to the dCTP deaminase family
WP2S18C03_23820	COG0572	uridine kinase
WP2S18C03_23830	COG0489	protein tyrosine kinase activity
WP2S18C03_23840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2S18C03_23840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2S18C03_23860	COG1254	Belongs to the acylphosphatase family
WP2S18C03_23880	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP2S18C03_23900	COG0709	Synthesizes selenophosphate from selenide and ATP
WP2S18C03_23910	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP2S18C03_23920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2S18C03_23940	COG0318	PFAM AMP-dependent synthetase and ligase
WP2S18C03_23950	COG0596	Alpha beta hydrolase
WP2S18C03_23970	COG1214	PFAM Peptidase M22, glycoprotease
WP2S18C03_23980	COG1199	ATP-dependent helicase activity
WP2S18C03_24000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP2S18C03_24010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP2S18C03_24020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP2S18C03_24030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP2S18C03_24030	COG0131	Imidazoleglycerol-phosphate dehydratase
WP2S18C03_24040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP2S18C03_24050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP2S18C03_24060	COG0107	imidazoleglycerol-phosphate synthase activity
WP2S18C03_24070	COG0140	phosphoribosyl-ATP diphosphatase activity
WP2S18C03_24070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WP2S18C03_24110	COG3706	GGDEF domain
WP2S18C03_24120	COG0318	PFAM AMP-dependent synthetase and ligase
WP2S18C03_24140	COG3134	Outer membrane lipoprotein
WP2S18C03_24150	COG2080	2 iron, 2 sulfur cluster binding
WP2S18C03_24160	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP2S18C03_24170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP2S18C03_24180	COG2252	PERMEase
WP2S18C03_24190	COG0402	S-adenosylhomocysteine deaminase activity
WP2S18C03_24200	COG2233	PERMEase
WP2S18C03_24210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP2S18C03_24210	COG2080	2 iron, 2 sulfur cluster binding
WP2S18C03_24220	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP2S18C03_24230	COG0402	S-adenosylhomocysteine deaminase activity
WP2S18C03_24240	COG0493	'glutamate synthase
WP2S18C03_24240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2S18C03_24250	COG2068	MobA-Related Protein
WP2S18C03_24260	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP2S18C03_24270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WP2S18C03_24270	COG3608	succinylglutamate desuccinylase aspartoacylase
WP2S18C03_24280	COG0697	spore germination
WP2S18C03_24290	COG0549	Belongs to the carbamate kinase family
WP2S18C03_24310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP2S18C03_24320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP2S18C03_24330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP2S18C03_24370	COG0242	peptide deformylase activity
WP2S18C03_24390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2S18C03_24400	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP2S18C03_24410	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP2S18C03_24430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP2S18C03_24440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP2S18C03_24460	COG0205	6-phosphofructokinase activity
WP2S18C03_24480	COG1301	dicarboxylic acid transport
WP2S18C03_24490	COG3123	guanosine phosphorylase activity
WP2S18C03_24500	COG1760	l-serine dehydratase
WP2S18C03_24510	COG1760	l-serine dehydratase
WP2S18C03_24550	COG0814	amino acid
WP2S18C03_24590	COG4584	PFAM Integrase catalytic
WP2S18C03_24600	COG1484	DNA-dependent DNA replication
WP2S18C03_24620	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP2S18C03_24630	COG0514	ATP-dependent DNA helicase (RecQ)
WP2S18C03_24640	COG2766	serine protein kinase
WP2S18C03_24650	COG2718	Belongs to the UPF0229 family
WP2S18C03_24660	COG2719	SpoVR family
WP2S18C03_24670	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2S18C03_24670	COG1024	Enoyl-CoA hydratase
WP2S18C03_24680	COG0183	Belongs to the thiolase family
WP2S18C03_24690	COG0714	Associated with various cellular activities
WP2S18C03_24760	COG1595	DNA-templated transcription, initiation
WP2S18C03_24780	COG2067	long-chain fatty acid transport protein
WP2S18C03_24790	COG2067	long-chain fatty acid transport protein
WP2S18C03_24800	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP2S18C03_24830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP2S18C03_24850	COG1643	Atp-dependent helicase
WP2S18C03_24860	COG0517	IMP dehydrogenase activity
WP2S18C03_24860	COG0617	tRNA 3'-terminal CCA addition
WP2S18C03_24860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP2S18C03_24870	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2S18C03_24900	COG1484	DNA-dependent DNA replication
WP2S18C03_24910	COG4584	PFAM Integrase catalytic
WP2S18C03_24940	COG2801	Transposase and inactivated derivatives
WP2S18C03_24980	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP2S18C03_25010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP2S18C03_25110	COG0045	succinate-CoA ligase (ADP-forming) activity
WP2S18C03_25120	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2S18C03_25130	COG0567	Dehydrogenase, E1 component
WP2S18C03_25150	COG1053	succinate dehydrogenase
WP2S18C03_25160	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP2S18C03_25170	COG2009	succinate dehydrogenase
WP2S18C03_25260	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP2S18C03_25290	COG2501	S4 domain
WP2S18C03_25310	COG1132	(ABC) transporter
WP2S18C03_25320	COG1132	(ABC) transporter
WP2S18C03_25330	COG4999	Histidine kinase
WP2S18C03_25330	COG3850	Histidine kinase
WP2S18C03_25330	COG3437	response regulator, receiver
WP2S18C03_25330	COG2205	protein histidine kinase activity
WP2S18C03_25340	COG3118	belongs to the thioredoxin family
WP2S18C03_25350	COG0471	metal ion transport
WP2S18C03_25360	COG0058	SHG alpha-glucan phosphorylase activity
WP2S18C03_25390	COG2983	Belongs to the UPF0260 family
WP2S18C03_25400	COG4584	PFAM Integrase catalytic
WP2S18C03_25410	COG1484	DNA-dependent DNA replication
WP2S18C03_25420	COG1882	Formate acetyltransferase
WP2S18C03_25430	COG2116	formate transmembrane transporter activity
WP2S18C03_25440	COG1944	ATP diphosphatase activity
WP2S18C03_25450	COG2723	6-phospho-beta-galactosidase activity
WP2S18C03_25460	COG0583	DNA-binding transcription factor activity
WP2S18C03_25490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP2S18C03_25500	COG0583	DNA-binding transcription factor activity
WP2S18C03_25520	COG1335	isochorismatase
WP2S18C03_25550	COG0583	DNA-binding transcription factor activity
WP2S18C03_25560	COG2910	NAD(P)H-binding
WP2S18C03_25590	COG1022	Amp-dependent synthetase and ligase
WP2S18C03_25620	COG0861	Integral membrane protein TerC family
WP2S18C03_25630	COG2885	chlorophyll binding
WP2S18C03_25640	COG3706	GGDEF domain
WP2S18C03_25680	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP2S18C03_25690	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP2S18C03_25710	COG3768	UPF0283 membrane protein
WP2S18C03_25720	COG3106	COG3106 Predicted ATPase
WP2S18C03_25750	COG1842	Phage shock protein A
WP2S18C03_25760	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP2S18C03_25810	COG4172	Belongs to the ABC transporter superfamily
WP2S18C03_25820	COG0326	Molecular chaperone. Has ATPase activity
WP2S18C03_25830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP2S18C03_25860	COG1435	thymidine kinase activity
WP2S18C03_25870	COG1757	Na H antiporter
WP2S18C03_25880	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP2S18C03_25890	COG2096	Adenosyltransferase
WP2S18C03_25900	COG3530	Putative quorum-sensing-regulated virulence factor
WP2S18C03_25910	COG0602	queuosine metabolic process
WP2S18C03_25920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP2S18C03_25960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP2S18C03_25980	COG0776	regulation of translation
WP2S18C03_25990	COG0539	negative regulation of cytoplasmic translation
WP2S18C03_26000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP2S18C03_26010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2S18C03_26040	COG2814	Major facilitator Superfamily
WP2S18C03_26080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP2S18C03_26090	COG3300	MHYT domain
WP2S18C03_26090	COG5001	Diguanylate cyclase
WP2S18C03_26100	COG0583	DNA-binding transcription factor activity
WP2S18C03_26110	COG3437	response regulator, receiver
WP2S18C03_26130	COG3385	transposase activity
WP2S18C03_26170	COG4989	oxidoreductase activity
WP2S18C03_26180	COG0724	RNA recognition motif
WP2S18C03_26210	COG0765	amino acid transport
WP2S18C03_26220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_26230	COG4597	amino acid ABC transporter
WP2S18C03_26240	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
WP2S18C03_26260	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP2S18C03_26280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2S18C03_26290	COG1360	Flagellar Motor Protein
WP2S18C03_26300	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_26310	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_26320	COG0649	NAD binding
WP2S18C03_26320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_26350	COG1034	ATP synthesis coupled electron transport
WP2S18C03_26360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP2S18C03_26370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_26380	COG0839	Belongs to the complex I subunit 6 family
WP2S18C03_26390	COG0713	ATP synthesis coupled electron transport
WP2S18C03_26410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_26420	COG1007	ATP synthesis coupled electron transport
WP2S18C03_26430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP2S18C03_26430	COG0047	phosphoribosylformylglycinamidine synthase activity
WP2S18C03_26440	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP2S18C03_26460	COG1645	bacterial-type flagellum-dependent swarming motility
WP2S18C03_26470	COG1160	GTP binding
WP2S18C03_26480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP2S18C03_26490	COG2976	Protein conserved in bacteria
WP2S18C03_26500	COG0124	histidyl-tRNA synthetase
WP2S18C03_26520	COG1426	Protein conserved in bacteria
WP2S18C03_26540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP2S18C03_26550	COG0105	UTP biosynthetic process
WP2S18C03_26580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP2S18C03_26600	COG0633	Ferredoxin
WP2S18C03_26610	COG0443	Heat shock 70 kDa protein
WP2S18C03_26620	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP2S18C03_26640	COG0822	iron-sulfur transferase activity
WP2S18C03_26650	COG1104	cysteine desulfurase activity
WP2S18C03_26660	COG1959	2 iron, 2 sulfur cluster binding
WP2S18C03_26690	COG3154	lipid carrier protein
WP2S18C03_26700	COG0826	peptidase U32
WP2S18C03_26710	COG0826	peptidase U32
WP2S18C03_26740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2S18C03_26750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP2S18C03_26760	COG1862	Preprotein translocase
WP2S18C03_26770	COG0343	queuine tRNA-ribosyltransferase activity
WP2S18C03_26780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP2S18C03_26790	COG1125	glycine betaine transport
WP2S18C03_26790	COG0517	IMP dehydrogenase activity
WP2S18C03_26810	COG3634	alkyl hydroperoxide reductase activity
WP2S18C03_26860	COG1484	DNA-dependent DNA replication
WP2S18C03_26870	COG4584	PFAM Integrase catalytic
WP2S18C03_26960	COG1242	4 iron, 4 sulfur cluster binding
WP2S18C03_26970	COG0069	glutamate synthase activity
WP2S18C03_26970	COG0067	glutamate synthase
WP2S18C03_26970	COG0070	glutamate synthase
WP2S18C03_26980	COG0493	'glutamate synthase
WP2S18C03_26990	COG1126	abc transporter atp-binding protein
WP2S18C03_27000	COG0765	amino acid transport
WP2S18C03_27010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_27040	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_27070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
WP2S18C03_27090	COG0023	Translation Initiation Factor
WP2S18C03_27100	COG2119	membrane
WP2S18C03_27210	COG0215	cysteine-tRNA ligase activity
WP2S18C03_27220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP2S18C03_27230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP2S18C03_27240	COG2261	transglycosylase associated protein
WP2S18C03_27250	COG0642	Histidine kinase
WP2S18C03_27360	COG2963	transposase activity
WP2S18C03_27420	COG1484	DNA-dependent DNA replication
WP2S18C03_27430	COG4584	PFAM Integrase catalytic
WP2S18C03_27470	COG1484	DNA-dependent DNA replication
WP2S18C03_27480	COG4584	PFAM Integrase catalytic
WP2S18C03_27490	COG0582	viral genome integration into host DNA
WP2S18C03_27740	COG0582	viral genome integration into host DNA
WP2S18C03_27760	COG0322	excinuclease ABC activity
WP2S18C03_27770	COG2197	response regulator
WP2S18C03_27780	COG3385	transposase activity
WP2S18C03_27790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP2S18C03_27800	COG2835	tetraacyldisaccharide 4'-kinase activity
WP2S18C03_27810	COG1663	tetraacyldisaccharide 4'-kinase activity
WP2S18C03_27830	COG0658	competence protein
WP2S18C03_27830	COG2333	competence protein COMEC
WP2S18C03_27860	COG1448	Aminotransferase
WP2S18C03_27880	COG0583	DNA-binding transcription factor activity
WP2S18C03_27890	COG3085	chromosome segregation
WP2S18C03_27900	COG4574	serine-type endopeptidase inhibitor activity
WP2S18C03_27910	COG0584	glycerophosphoryl diester phosphodiesterase
WP2S18C03_27930	COG1349	DNA-binding transcription factor activity
WP2S18C03_27940	COG2271	Major facilitator Superfamily
WP2S18C03_27950	COG1484	DNA-dependent DNA replication
WP2S18C03_27960	COG4584	PFAM Integrase catalytic
WP2S18C03_27970	COG2271	Major facilitator Superfamily
WP2S18C03_28000	COG2271	Major facilitator Superfamily
WP2S18C03_28010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2S18C03_28020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP2S18C03_28030	COG0840	transmembrane signaling receptor activity
WP2S18C03_28050	COG0583	DNA-binding transcription factor activity
WP2S18C03_28090	COG0656	L-ascorbic acid biosynthetic process
WP2S18C03_28100	COG2814	Major facilitator Superfamily
WP2S18C03_28110	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP2S18C03_28140	COG3220	belongs to the UPF0276 family
WP2S18C03_28180	COG1294	oxidase, subunit
WP2S18C03_28200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2S18C03_28220	COG2979	Protein of unknown function (DUF533)
WP2S18C03_28250	COG0583	DNA-binding transcription factor activity
WP2S18C03_28270	COG2807	transmembrane transport
WP2S18C03_28280	COG1187	pseudouridine synthase activity
WP2S18C03_28320	COG4657	Part of a membrane complex involved in electron transport
WP2S18C03_28330	COG2878	Part of a membrane complex involved in electron transport
WP2S18C03_28350	COG4658	electron transport chain
WP2S18C03_28360	COG4659	FMN binding
WP2S18C03_28370	COG4660	Part of a membrane complex involved in electron transport
WP2S18C03_28380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP2S18C03_28390	COG0346	lactoylglutathione lyase activity
WP2S18C03_28420	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP2S18C03_28450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP2S18C03_28460	COG0505	Belongs to the CarA family
WP2S18C03_28470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP2S18C03_28490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP2S18C03_28500	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP2S18C03_28510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP2S18C03_28520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP2S18C03_28530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP2S18C03_28590	COG2020	methyltransferase activity
WP2S18C03_28600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2S18C03_28610	COG0861	Integral membrane protein TerC family
WP2S18C03_28640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2S18C03_28650	COG0601	transmembrane transport
WP2S18C03_28670	COG2095	MarC family integral membrane protein
WP2S18C03_28680	COG1012	belongs to the aldehyde dehydrogenase family
WP2S18C03_28680	COG1454	alcohol dehydrogenase
WP2S18C03_28690	COG0217	transcriptional regulatory protein
WP2S18C03_28700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP2S18C03_28720	COG1801	Protein of unknown function DUF72
WP2S18C03_28730	COG4106	trans-aconitate 2-methyltransferase activity
WP2S18C03_28740	COG0500	methyltransferase
WP2S18C03_28790	COG2963	transposase activity
WP2S18C03_28800	COG0450	alkyl hydroperoxide reductase
WP2S18C03_28810	COG0583	DNA-binding transcription factor activity
WP2S18C03_28820	COG0791	NLP P60 protein
WP2S18C03_28840	COG0538	isocitrate dehydrogenase activity
WP2S18C03_28850	COG2207	Transcriptional regulator
WP2S18C03_28900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_28930	COG3152	Membrane
WP2S18C03_28940	COG2814	Major facilitator Superfamily
WP2S18C03_28950	COG0109	protoheme IX farnesyltransferase activity
WP2S18C03_28960	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WP2S18C03_28970	COG1845	cytochrome c oxidase, subunit III
WP2S18C03_28980	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WP2S18C03_28990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
WP2S18C03_29020	COG2010	Cytochrome c
WP2S18C03_29070	COG1309	transcriptional regulator
WP2S18C03_29090	COG1454	alcohol dehydrogenase
WP2S18C03_29130	COG0534	Mate efflux family protein
WP2S18C03_29150	COG2841	Protein conserved in bacteria
WP2S18C03_29160	COG3132	Protein of unknown function, DUF480
WP2S18C03_29220	COG0708	Exodeoxyribonuclease III
WP2S18C03_29260	COG1122	ATPase activity
WP2S18C03_29270	COG1122	ATPase activity
WP2S18C03_29310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP2S18C03_29320	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP2S18C03_29350	COG1120	ATPase activity
WP2S18C03_29360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2S18C03_29370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2S18C03_29380	COG2375	cellular response to nickel ion
WP2S18C03_29390	COG0784	Response regulator, receiver
WP2S18C03_29390	COG3437	response regulator, receiver
WP2S18C03_29410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2S18C03_29420	COG0328	RNA-DNA hybrid ribonuclease activity
WP2S18C03_29430	COG2226	methyltransferase
WP2S18C03_29440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP2S18C03_29450	COG0741	lytic transglycosylase activity
WP2S18C03_29450	COG1388	LysM domain
WP2S18C03_29500	COG0582	viral genome integration into host DNA
WP2S18C03_29520	COG4584	PFAM Integrase catalytic
WP2S18C03_29530	COG1484	DNA-dependent DNA replication
WP2S18C03_29540	COG1376	ErfK ybiS ycfS ynhG family protein
WP2S18C03_29540	COG1388	LysM domain
WP2S18C03_29560	COG0471	metal ion transport
WP2S18C03_29580	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP2S18C03_29590	COG0791	NLP P60 protein
WP2S18C03_29610	COG3118	belongs to the thioredoxin family
WP2S18C03_29630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP2S18C03_29640	COG0788	formyltetrahydrofolate deformylase activity
WP2S18C03_29690	COG0739	heme binding
WP2S18C03_29690	COG0741	lytic transglycosylase activity
WP2S18C03_29690	COG1196	nuclear chromosome segregation
WP2S18C03_29700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP2S18C03_29720	COG0436	Aminotransferase
WP2S18C03_29740	COG1288	antiporter activity
WP2S18C03_29760	COG1879	ABC-type sugar transport system periplasmic component
WP2S18C03_29780	COG0406	alpha-ribazole phosphatase activity
WP2S18C03_29790	COG2964	Protein conserved in bacteria
WP2S18C03_29800	COG3681	Belongs to the UPF0597 family
WP2S18C03_29820	COG0814	amino acid
WP2S18C03_29860	COG1166	arginine decarboxylase activity
WP2S18C03_29870	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2S18C03_29930	COG0583	DNA-binding transcription factor activity
WP2S18C03_29950	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP2S18C03_29960	COG0840	transmembrane signaling receptor activity
WP2S18C03_29970	COG0302	gtp cyclohydrolase
WP2S18C03_29980	COG0303	'Molybdopterin
WP2S18C03_29990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP2S18C03_30010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP2S18C03_30040	COG0314	molybdopterin synthase activity
WP2S18C03_30060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP2S18C03_30070	COG0315	cyclic pyranopterin monophosphate synthase activity
WP2S18C03_30080	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2S18C03_30090	COG3005	denitrification pathway
WP2S18C03_30110	COG0348	domain, Protein
WP2S18C03_30120	COG0437	4 iron, 4 sulfur cluster binding
WP2S18C03_30130	COG0243	molybdopterin cofactor binding
WP2S18C03_30150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2S18C03_30160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP2S18C03_30170	COG3850	Histidine kinase
WP2S18C03_30180	COG2197	response regulator
WP2S18C03_30240	COG0121	glutamine amidotransferase
WP2S18C03_30250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2S18C03_30260	COG1960	acyl-CoA dehydrogenase activity
WP2S18C03_30270	COG1473	amidohydrolase
WP2S18C03_30280	COG2914	Belongs to the UPF0125 (RnfH) family
WP2S18C03_30290	COG2867	negative regulation of translational initiation
WP2S18C03_30300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP2S18C03_30650	COG3646	Phage regulatory protein
WP2S18C03_30650	COG3645	SOS response
WP2S18C03_30830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP2S18C03_30910	COG2974	May be involved in recombination
WP2S18C03_31020	COG0582	viral genome integration into host DNA
WP2S18C03_31030	COG0582	viral genome integration into host DNA
WP2S18C03_31080	COG2814	Major facilitator Superfamily
WP2S18C03_31080	COG0477	Major facilitator Superfamily
WP2S18C03_31090	COG0457	Tetratricopeptide repeat
WP2S18C03_31100	COG1940	carbohydrate kinase activity
WP2S18C03_31110	COG3383	formate dehydrogenase (NAD+) activity
WP2S18C03_31220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP2S18C03_31250	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WP2S18C03_31300	COG3039	Transposase
WP2S18C03_31310	COG3706	GGDEF domain
WP2S18C03_31340	COG3447	MASE1 domain protein
WP2S18C03_31340	COG5002	protein histidine kinase activity
WP2S18C03_31340	COG5001	Diguanylate cyclase
WP2S18C03_31380	COG3311	Transcriptional regulator
WP2S18C03_31390	COG4983	Phage plasmid primase, P4 family domain protein
WP2S18C03_31410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP2S18C03_31430	COG1960	acyl-CoA dehydrogenase activity
WP2S18C03_31440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP2S18C03_31490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP2S18C03_31500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_31500	COG1263	PTS System
WP2S18C03_31510	COG1609	Transcriptional regulator
WP2S18C03_31580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_31580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_31580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_31600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP2S18C03_31620	COG1187	pseudouridine synthase activity
WP2S18C03_31630	COG1051	belongs to the nudix hydrolase family
WP2S18C03_31640	COG0482	sulfurtransferase activity
WP2S18C03_31650	COG2915	High frequency lysogenization protein hflD homolog
WP2S18C03_31660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP2S18C03_31670	COG2850	peptidyl-arginine hydroxylation
WP2S18C03_31700	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
WP2S18C03_31730	COG1397	ADP-ribosylglycohydrolase
WP2S18C03_31750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2S18C03_31790	COG0625	glutathione transferase activity
WP2S18C03_31800	COG0259	pyridoxamine-phosphate oxidase activity
WP2S18C03_31840	COG4584	PFAM Integrase catalytic
WP2S18C03_31850	COG1484	DNA-dependent DNA replication
WP2S18C03_31870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP2S18C03_31880	COG1882	Formate acetyltransferase
WP2S18C03_31900	COG1882	Formate acetyltransferase
WP2S18C03_31920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2S18C03_31920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2S18C03_31940	COG1484	DNA-dependent DNA replication
WP2S18C03_31950	COG4584	PFAM Integrase catalytic
WP2S18C03_31990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP2S18C03_32020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP2S18C03_32070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2S18C03_32080	COG1138	Cytochrome C-type biogenesis protein
WP2S18C03_32090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP2S18C03_32100	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2S18C03_32110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2S18C03_32120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP2S18C03_32160	COG0835	chemotaxis
WP2S18C03_32180	COG1192	Involved in chromosome partitioning
WP2S18C03_32190	COG1360	Flagellar Motor Protein
WP2S18C03_32200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP2S18C03_32210	COG2201	protein-glutamate methylesterase activity
WP2S18C03_32220	COG0643	Histidine kinase
WP2S18C03_32220	COG0784	Response regulator, receiver
WP2S18C03_32220	COG2198	Histidine kinase
WP2S18C03_32230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP2S18C03_32280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP2S18C03_32300	COG1684	flagellar biosynthetic protein fliR
WP2S18C03_32410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP2S18C03_32430	COG1677	Flagellar hook-basal body complex protein FliE
WP2S18C03_32450	COG0469	pyruvate kinase activity
WP2S18C03_32460	COG1737	Transcriptional regulator
WP2S18C03_32530	COG2233	PERMEase
WP2S18C03_32560	COG0281	malic enzyme
WP2S18C03_32570	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_32590	COG0437	4 iron, 4 sulfur cluster binding
WP2S18C03_32600	COG3383	formate dehydrogenase (NAD+) activity
WP2S18C03_32600	COG3383	formate dehydrogenase (NAD+) activity
WP2S18C03_32670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP2S18C03_32690	COG3852	Histidine kinase
WP2S18C03_32700	COG2204	response regulator
WP2S18C03_32720	COG4662	Binding-protein-dependent transport system inner membrane component
WP2S18C03_32730	COG1136	(ABC) transporter
WP2S18C03_32740	COG0746	molybdenum cofactor guanylyltransferase activity
WP2S18C03_32750	COG0303	'Molybdopterin
WP2S18C03_32760	COG1289	transmembrane transporter activity
WP2S18C03_32770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2S18C03_32780	COG1484	DNA-dependent DNA replication
WP2S18C03_32790	COG4584	PFAM Integrase catalytic
WP2S18C03_32800	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP2S18C03_32860	COG0784	Response regulator, receiver
WP2S18C03_32860	COG2205	protein histidine kinase activity
WP2S18C03_32870	COG4166	transmembrane transport
WP2S18C03_32880	COG0601	transmembrane transport
WP2S18C03_32890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP2S18C03_32900	COG0444	Belongs to the ABC transporter superfamily
WP2S18C03_32910	COG4608	Belongs to the ABC transporter superfamily
WP2S18C03_32930	COG2971	BadF BadG BcrA BcrD
WP2S18C03_33030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP2S18C03_33040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP2S18C03_33060	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP2S18C03_33070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP2S18C03_33090	COG0180	Tryptophanyl-tRNA synthetase
WP2S18C03_33120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP2S18C03_33140	COG1012	belongs to the aldehyde dehydrogenase family
WP2S18C03_33160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2S18C03_33180	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP2S18C03_33180	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP2S18C03_33180	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP2S18C03_33180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP2S18C03_33190	COG0366	Alpha amylase catalytic
WP2S18C03_33230	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
WP2S18C03_33250	COG0490	domain, Protein
WP2S18C03_33250	COG0471	metal ion transport
WP2S18C03_33280	COG0583	DNA-binding transcription factor activity
WP2S18C03_33290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP2S18C03_33300	COG3842	ATPase activity
WP2S18C03_33310	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP2S18C03_33320	COG1177	transmembrane transport
WP2S18C03_33330	COG1012	belongs to the aldehyde dehydrogenase family
WP2S18C03_33340	COG0012	GTP binding
WP2S18C03_33350	COG0193	aminoacyl-tRNA hydrolase activity
WP2S18C03_33360	COG0737	Belongs to the 5'-nucleotidase family
WP2S18C03_33370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP2S18C03_33380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP2S18C03_33390	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP2S18C03_33400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP2S18C03_33410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP2S18C03_33420	COG2890	protein-(glutamine-N5) methyltransferase activity
WP2S18C03_33440	COG2912	Transglutaminase-like superfamily
WP2S18C03_33450	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP2S18C03_33460	COG1301	dicarboxylic acid transport
WP2S18C03_33490	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP2S18C03_33510	COG3408	Glycogen debranching enzyme
WP2S18C03_33510	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WP2S18C03_33530	COG1881	PFAM PEBP family protein
WP2S18C03_33570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP2S18C03_33590	COG0583	DNA-binding transcription factor activity
WP2S18C03_33600	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_33610	COG0616	signal peptide processing
WP2S18C03_33620	COG2211	Major facilitator Superfamily
WP2S18C03_33630	COG2203	Gaf domain
WP2S18C03_33630	COG2199	diguanylate cyclase activity
WP2S18C03_33640	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP2S18C03_33660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP2S18C03_33680	COG2199	diguanylate cyclase activity
WP2S18C03_33680	COG2203	Gaf domain
WP2S18C03_33680	COG2200	EAL domain
WP2S18C03_33720	COG5433	transposase activity
WP2S18C03_33740	COG2197	response regulator
WP2S18C03_33750	COG2205	protein histidine kinase activity
WP2S18C03_33750	COG0784	Response regulator, receiver
WP2S18C03_33750	COG5002	protein histidine kinase activity
WP2S18C03_33770	COG3724	N-succinylarginine dihydrolase activity
WP2S18C03_33820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP2S18C03_33830	COG0583	DNA-binding transcription factor activity
WP2S18C03_33870	COG0583	DNA-binding transcription factor activity
WP2S18C03_33890	COG0739	heme binding
WP2S18C03_33910	COG1511	domain protein
WP2S18C03_33910	COG3264	Mechanosensitive ion channel
WP2S18C03_33920	COG0584	glycerophosphoryl diester phosphodiesterase
WP2S18C03_33970	COG1053	succinate dehydrogenase
WP2S18C03_33980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP2S18C03_33990	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2S18C03_34000	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP2S18C03_34010	COG3366	ferrous iron transmembrane transporter activity
WP2S18C03_34020	COG0700	Nucleoside recognition
WP2S18C03_34030	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP2S18C03_34050	COG3214	Protein conserved in bacteria
WP2S18C03_34080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_34090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_34140	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_34190	COG0516	GMP reductase activity
WP2S18C03_34210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP2S18C03_34230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP2S18C03_34250	COG0583	DNA-binding transcription factor activity
WP2S18C03_34260	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
WP2S18C03_34280	COG3069	C4-dicarboxylate transmembrane transporter activity
WP2S18C03_34330	COG3706	GGDEF domain
WP2S18C03_34340	COG1335	isochorismatase
WP2S18C03_34360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP2S18C03_34370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP2S18C03_34380	COG1702	phosphate starvation-inducible protein PhoH
WP2S18C03_34390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP2S18C03_34400	COG4535	Mg2 and Co2 transporter CorC
WP2S18C03_34410	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP2S18C03_34460	COG1970	mechanosensitive ion channel activity
WP2S18C03_34470	COG4974	Belongs to the 'phage' integrase family
WP2S18C03_34480	COG0716	FMN binding
WP2S18C03_34500	COG0312	modulator of DNA gyrase
WP2S18C03_34520	COG2888	peptidyl-tyrosine sulfation
WP2S18C03_34530	COG0495	leucyl-tRNA aminoacylation
WP2S18C03_34560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP2S18C03_34570	COG0799	negative regulation of ribosome biogenesis
WP2S18C03_34580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP2S18C03_34590	COG0768	penicillin binding
WP2S18C03_34600	COG0772	Belongs to the SEDS family
WP2S18C03_34610	COG2951	lytic endotransglycosylase activity
WP2S18C03_34620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP2S18C03_34630	COG1686	Belongs to the peptidase S11 family
WP2S18C03_34640	COG2921	Belongs to the UPF0250 family
WP2S18C03_34650	COG0321	lipoyl(octanoyl) transferase activity
WP2S18C03_34660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP2S18C03_34700	COG3139	Protein of unknown function (DUF1315)
WP2S18C03_34710	COG0252	asparaginase activity
WP2S18C03_34720	COG0786	glutamate:sodium symporter activity
WP2S18C03_34740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP2S18C03_34750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP2S18C03_34760	COG0384	phenazine biosynthesis protein PhzF
WP2S18C03_34770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP2S18C03_34780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP2S18C03_34790	COG0175	sulfate reduction
WP2S18C03_34820	COG2966	Psort location CytoplasmicMembrane, score
WP2S18C03_34840	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP2S18C03_34870	COG2897	thiosulfate sulfurtransferase activity
WP2S18C03_34880	COG2066	Belongs to the glutaminase family
WP2S18C03_34890	COG3171	Protein conserved in bacteria
WP2S18C03_34900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP2S18C03_34910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2S18C03_34920	COG2200	EAL domain
WP2S18C03_34920	COG2771	luxR family
WP2S18C03_34940	COG1090	epimerase
WP2S18C03_34950	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP2S18C03_34960	COG4181	ATPase activity
WP2S18C03_34970	COG2755	lipolytic protein G-D-S-L family
WP2S18C03_34980	COG0784	Response regulator, receiver
WP2S18C03_34980	COG0835	chemotaxis
WP2S18C03_35020	COG3397	chitin binding
WP2S18C03_35050	COG2205	protein histidine kinase activity
WP2S18C03_35050	COG0784	Response regulator, receiver
WP2S18C03_35050	COG5002	protein histidine kinase activity
WP2S18C03_35070	COG3655	Transcriptional regulator
WP2S18C03_35090	COG2814	Major facilitator Superfamily
WP2S18C03_35150	COG0748	coenzyme F420 binding
WP2S18C03_35160	COG3721	Heme iron utilization protein
WP2S18C03_35180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP2S18C03_35230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP2S18C03_35310	COG2204	response regulator
WP2S18C03_35320	COG0545	Peptidyl-prolyl cis-trans isomerase
WP2S18C03_35350	COG1047	Peptidyl-prolyl cis-trans
WP2S18C03_35360	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP2S18C03_35380	COG0784	Response regulator, receiver
WP2S18C03_35380	COG0835	chemotaxis
WP2S18C03_35390	COG0429	hydrolase of the alpha beta-hydrolase fold
WP2S18C03_35400	COG5001	Diguanylate cyclase
WP2S18C03_35400	COG4251	negative regulation of phosphorylation
WP2S18C03_35400	COG3706	GGDEF domain
WP2S18C03_35400	COG2203	Gaf domain
WP2S18C03_35410	COG3089	Belongs to the UPF0270 family
WP2S18C03_35420	COG3954	Phosphoribulokinase
WP2S18C03_35450	COG1765	OsmC-like protein
WP2S18C03_35530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2S18C03_35540	COG2313	pseudouridylate synthase activity
WP2S18C03_35610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP2S18C03_35640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2S18C03_35660	COG2986	histidine ammonia-lyase
WP2S18C03_35710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2S18C03_35720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP2S18C03_35730	COG1028	Short-chain dehydrogenase reductase Sdr
WP2S18C03_35740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP2S18C03_35760	COG0582	viral genome integration into host DNA
WP2S18C03_35800	COG1484	DNA-dependent DNA replication
WP2S18C03_35810	COG4584	PFAM Integrase catalytic
WP2S18C03_35850	COG4974	Belongs to the 'phage' integrase family
WP2S18C03_35920	COG5001	Diguanylate cyclase
WP2S18C03_35920	COG2203	Gaf domain
WP2S18C03_35920	COG4251	negative regulation of phosphorylation
WP2S18C03_35920	COG3706	GGDEF domain
WP2S18C03_35930	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP2S18C03_35980	COG0569	domain protein
WP2S18C03_35980	COG2985	domain, Protein
WP2S18C03_35990	COG1272	protein, Hemolysin III
WP2S18C03_36000	COG0076	glutamate decarboxylase activity
WP2S18C03_36010	COG2917	probably involved in intracellular septation
WP2S18C03_36020	COG2350	Protein conserved in bacteria
WP2S18C03_36040	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP2S18C03_36050	COG1381	Involved in DNA repair and RecF pathway recombination
WP2S18C03_36080	COG0681	Belongs to the peptidase S26 family
WP2S18C03_36090	COG0481	GTPase activity
WP2S18C03_36110	COG3026	antisigma factor binding
WP2S18C03_36120	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP2S18C03_36130	COG1595	DNA-templated transcription, initiation
WP2S18C03_36140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP2S18C03_36170	COG0354	folic acid binding
WP2S18C03_36260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP2S18C03_36280	COG0126	phosphoglycerate kinase activity
WP2S18C03_36290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2S18C03_36300	COG1940	carbohydrate kinase activity
WP2S18C03_36310	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP2S18C03_36320	COG2816	NAD+ diphosphatase activity
WP2S18C03_36330	COG2816	NAD+ diphosphatase activity
WP2S18C03_36350	COG4991	sh3 domain protein
WP2S18C03_36360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2S18C03_36390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP2S18C03_36460	COG2816	NAD+ diphosphatase activity
WP2S18C03_36500	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP2S18C03_36520	COG2199	diguanylate cyclase activity
WP2S18C03_36520	COG2203	Gaf domain
WP2S18C03_36530	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_36550	COG0471	metal ion transport
WP2S18C03_36580	COG0154	amidase activity
WP2S18C03_36590	COG2957	Belongs to the agmatine deiminase family
WP2S18C03_36610	COG2852	Protein conserved in bacteria
WP2S18C03_36630	COG1902	pentaerythritol trinitrate reductase activity
WP2S18C03_36650	COG1388	LysM domain
WP2S18C03_36650	COG4942	peptidase
WP2S18C03_36660	COG1238	metal cluster binding
WP2S18C03_36670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP2S18C03_36680	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP2S18C03_36690	COG0585	pseudouridine synthase activity
WP2S18C03_36710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP2S18C03_36720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP2S18C03_36730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP2S18C03_36750	COG1376	ErfK ybiS ycfS ynhG family protein
WP2S18C03_36760	COG0668	transmembrane transport
WP2S18C03_36780	COG2731	YhcH YjgK YiaL family protein
WP2S18C03_36800	COG1794	racemase activity, acting on amino acids and derivatives
WP2S18C03_36830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP2S18C03_36870	COG0488	(ABC) transporter
WP2S18C03_36890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP2S18C03_36930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WP2S18C03_36950	COG0148	phosphopyruvate hydratase activity
WP2S18C03_36960	COG0504	CTP synthase activity
WP2S18C03_36970	COG3956	TIGRFAM MazG family protein
WP2S18C03_36980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP2S18C03_36990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2S18C03_37010	COG4807	Protein conserved in bacteria
WP2S18C03_37020	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP2S18C03_37030	COG0783	Belongs to the Dps family
WP2S18C03_37040	COG1151	hydroxylamine reductase activity
WP2S18C03_37050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP2S18C03_37060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP2S18C03_37070	COG0671	phosphoesterase, PA-phosphatase related
WP2S18C03_37080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2S18C03_37090	COG0163	prenyltransferase activity
WP2S18C03_37120	COG1131	(ABC) transporter
WP2S18C03_37130	COG0842	Transport permease protein
WP2S18C03_37140	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WP2S18C03_37150	COG1924	4 iron, 4 sulfur cluster binding
WP2S18C03_37200	COG1486	melibiose metabolic process
WP2S18C03_37250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP2S18C03_37260	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP2S18C03_37270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP2S18C03_37290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP2S18C03_37300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP2S18C03_37310	COG1489	DNA binding
WP2S18C03_37330	COG1643	Atp-dependent helicase
WP2S18C03_37340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP2S18C03_37350	COG0346	lactoylglutathione lyase activity
WP2S18C03_37360	COG2076	Multidrug Resistance protein
WP2S18C03_37370	COG2076	Multidrug Resistance protein
WP2S18C03_37390	COG3437	response regulator, receiver
WP2S18C03_37390	COG0784	Response regulator, receiver
WP2S18C03_37400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP2S18C03_37430	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP2S18C03_37500	COG0840	transmembrane signaling receptor activity
WP2S18C03_37510	COG1484	DNA-dependent DNA replication
WP2S18C03_37520	COG4584	PFAM Integrase catalytic
WP2S18C03_37530	COG0840	transmembrane signaling receptor activity
WP2S18C03_37540	COG0529	Catalyzes the synthesis of activated sulfate
WP2S18C03_37550	COG2895	sulfate adenylyltransferase (ATP) activity
WP2S18C03_37560	COG0175	sulfate reduction
WP2S18C03_37570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP2S18C03_37570	COG1648	precorrin-2 dehydrogenase activity
WP2S18C03_37580	COG0330	HflC and HflK could
WP2S18C03_37590	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP2S18C03_37600	COG0840	transmembrane signaling receptor activity
WP2S18C03_37610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP2S18C03_37630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP2S18C03_37640	COG1640	4-alpha-glucanotransferase
WP2S18C03_37650	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP2S18C03_37690	COG1051	belongs to the nudix hydrolase family
WP2S18C03_37740	COG0561	phosphatase activity
WP2S18C03_37770	COG0733	neurotransmitter:sodium symporter activity
WP2S18C03_37790	COG0733	neurotransmitter:sodium symporter activity
WP2S18C03_37800	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP2S18C03_37810	COG2885	chlorophyll binding
WP2S18C03_37820	COG0823	Involved in the tonB-independent uptake of proteins
WP2S18C03_37850	COG0811	peptide transport
WP2S18C03_37860	COG0824	Thioesterase
WP2S18C03_37870	COG3790	cyd operon protein YbgE
WP2S18C03_37880	COG4890	Cyd operon protein YbgT
WP2S18C03_37890	COG1294	oxidase, subunit
WP2S18C03_37910	COG2255	four-way junction helicase activity
WP2S18C03_37920	COG0632	four-way junction helicase activity
WP2S18C03_37930	COG0840	transmembrane signaling receptor activity
WP2S18C03_37950	COG2771	luxR family
WP2S18C03_37960	COG3916	Acyl-homoserine-lactone synthase
WP2S18C03_37980	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP2S18C03_37990	COG5001	Diguanylate cyclase
WP2S18C03_37990	COG4251	negative regulation of phosphorylation
WP2S18C03_37990	COG2203	Gaf domain
WP2S18C03_37990	COG3706	GGDEF domain
WP2S18C03_38010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP2S18C03_38030	COG2995	paraquat-inducible protein a
WP2S18C03_38040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2S18C03_38040	COG3008	intermembrane lipid transfer
WP2S18C03_38050	COG3009	Protein conserved in bacteria
WP2S18C03_38060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP2S18C03_38070	COG0442	prolyl-tRNA aminoacylation
WP2S18C03_38090	COG1309	transcriptional regulator
WP2S18C03_38120	COG4221	oxidoreductase activity
WP2S18C03_38150	COG1024	Enoyl-CoA hydratase
WP2S18C03_38170	COG0110	maltose O-acetyltransferase activity
WP2S18C03_38190	COG4166	transmembrane transport
WP2S18C03_38210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP2S18C03_38220	COG0735	belongs to the Fur family
WP2S18C03_38270	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP2S18C03_38280	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_38290	COG2153	protein acetylation
WP2S18C03_38320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP2S18C03_38330	COG0557	exoribonuclease II activity
WP2S18C03_38340	COG3706	GGDEF domain
WP2S18C03_38360	COG3240	lipase activity
WP2S18C03_38390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP2S18C03_38400	COG1194	a g-specific adenine glycosylase
WP2S18C03_38410	COG0617	tRNA 3'-terminal CCA addition
WP2S18C03_38450	COG3068	Protein conserved in bacteria
WP2S18C03_38470	COG0739	heme binding
WP2S18C03_38510	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP2S18C03_38520	COG1121	(ABC) transporter
WP2S18C03_38530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP2S18C03_38540	COG0583	DNA-binding transcription factor activity
WP2S18C03_38550	COG0697	spore germination
WP2S18C03_38560	COG1573	uracil-dna glycosylase
WP2S18C03_38590	COG2827	Endonuclease containing a URI domain
WP2S18C03_38620	COG1842	Phage shock protein A
WP2S18C03_38630	COG0204	Acyl-transferase
WP2S18C03_38670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP2S18C03_38680	COG0583	DNA-binding transcription factor activity
WP2S18C03_38750	COG3104	oligopeptide transport
WP2S18C03_38790	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP2S18C03_38820	COG0187	DNA topoisomerase II activity
WP2S18C03_38830	COG1289	transmembrane transporter activity
WP2S18C03_38840	COG1566	PFAM secretion protein HlyD family protein
WP2S18C03_38880	COG1051	belongs to the nudix hydrolase family
WP2S18C03_38890	COG3150	esterase
WP2S18C03_38910	COG3151	Protein conserved in bacteria
WP2S18C03_38920	COG0494	nUDIX hydrolase
WP2S18C03_38930	COG1538	Outer membrane efflux protein
WP2S18C03_38940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP2S18C03_38940	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP2S18C03_38950	COG1560	Kdo2-lipid A biosynthetic process
WP2S18C03_38960	COG2213	PTS system mannitol-specific
WP2S18C03_38960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_38970	COG0246	Mannitol dehydrogenase
WP2S18C03_38980	COG3722	fumarate hydratase activity
WP2S18C03_39030	COG1671	Belongs to the UPF0178 family
WP2S18C03_39060	COG1988	membrane-bound metal-dependent
WP2S18C03_39070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP2S18C03_39080	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_39120	COG1575	Belongs to the MenA family. Type 1 subfamily
WP2S18C03_39130	COG1169	isochorismate synthase
WP2S18C03_39140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP2S18C03_39150	COG0596	Alpha beta hydrolase
WP2S18C03_39160	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP2S18C03_39180	COG0318	PFAM AMP-dependent synthetase and ligase
WP2S18C03_39210	COG3539	Fimbrial protein
WP2S18C03_39230	COG3121	Chaperone
WP2S18C03_39240	COG3188	usher protein
WP2S18C03_39300	COG3291	Pkd domain containing protein
WP2S18C03_39310	COG2949	membrane
WP2S18C03_39320	COG0835	chemotaxis
WP2S18C03_39320	COG0784	Response regulator, receiver
WP2S18C03_39340	COG1444	tRNA N-acetyltransferase activity
WP2S18C03_39380	COG1803	Methylglyoxal synthase
WP2S18C03_39390	COG1979	alcohol dehydrogenase
WP2S18C03_39420	COG4221	oxidoreductase activity
WP2S18C03_39460	COG1285	pathogenesis
WP2S18C03_39500	COG1368	sulfuric ester hydrolase activity
WP2S18C03_39510	COG1522	sequence-specific DNA binding
WP2S18C03_39530	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP2S18C03_39540	COG1418	mRNA catabolic process
WP2S18C03_39550	COG1546	Belongs to the CinA family
WP2S18C03_39550	COG1058	Belongs to the CinA family
WP2S18C03_39570	COG0561	phosphatase activity
WP2S18C03_39590	COG2926	Belongs to the UPF0265 family
WP2S18C03_39630	COG1484	DNA-dependent DNA replication
WP2S18C03_39640	COG4584	PFAM Integrase catalytic
WP2S18C03_39700	COG3655	Transcriptional regulator
WP2S18C03_39820	COG4584	PFAM Integrase catalytic
WP2S18C03_39830	COG1484	DNA-dependent DNA replication
WP2S18C03_39860	COG0840	transmembrane signaling receptor activity
WP2S18C03_39870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_39930	COG4584	PFAM Integrase catalytic
WP2S18C03_39940	COG1484	DNA-dependent DNA replication
WP2S18C03_40010	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP2S18C03_40020	COG0564	pseudouridine synthase activity
WP2S18C03_40040	COG0110	maltose O-acetyltransferase activity
WP2S18C03_40050	COG0366	Alpha amylase catalytic
WP2S18C03_40060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP2S18C03_40060	COG1263	PTS System
WP2S18C03_40100	COG0252	asparaginase activity
WP2S18C03_40110	COG1253	flavin adenine dinucleotide binding
WP2S18C03_40120	COG0586	Pfam SNARE associated Golgi protein
WP2S18C03_40130	COG1686	Belongs to the peptidase S11 family
WP2S18C03_40140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP2S18C03_40160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP2S18C03_40170	COG2137	regulation of response to DNA damage stimulus
WP2S18C03_40180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP2S18C03_40190	COG1546	Belongs to the CinA family
WP2S18C03_40210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WP2S18C03_40240	COG0582	viral genome integration into host DNA
WP2S18C03_40250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP2S18C03_40260	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP2S18C03_40270	COG4667	esterase of the alpha-beta hydrolase superfamily
WP2S18C03_40290	COG1346	cytolysis
WP2S18C03_40300	COG1380	Effector of murein hydrolase LrgA
WP2S18C03_40340	COG0583	DNA-binding transcription factor activity
WP2S18C03_40400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP2S18C03_40420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP2S18C03_40430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP2S18C03_40450	COG0137	argininosuccinate synthase activity
WP2S18C03_40460	COG0165	Argininosuccinate lyase
WP2S18C03_40500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP2S18C03_40510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP2S18C03_40530	COG0477	Major facilitator Superfamily
WP2S18C03_40540	COG0523	cobalamin synthesis protein
WP2S18C03_40560	COG2200	EAL domain
WP2S18C03_40570	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP2S18C03_40580	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP2S18C03_40590	COG0840	transmembrane signaling receptor activity
WP2S18C03_40610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP2S18C03_40620	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP2S18C03_40630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP2S18C03_40640	COG2186	Transcriptional regulator
WP2S18C03_40680	COG4969	Belongs to the N-Me-Phe pilin family
WP2S18C03_40690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP2S18C03_40700	COG1459	type II secretion system
WP2S18C03_40730	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP2S18C03_40740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP2S18C03_40750	COG0494	nUDIX hydrolase
WP2S18C03_40760	COG0653	protein targeting
WP2S18C03_40780	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP2S18C03_40790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP2S18C03_40800	COG0849	cell division
WP2S18C03_40820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP2S18C03_40830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP2S18C03_40840	COG0772	Belongs to the SEDS family
WP2S18C03_40850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP2S18C03_40860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP2S18C03_40870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP2S18C03_40880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP2S18C03_40890	COG0768	penicillin binding
WP2S18C03_40900	COG3116	cell division
WP2S18C03_40910	COG0275	rRNA processing
WP2S18C03_40920	COG2001	Belongs to the MraZ family
WP2S18C03_40930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP2S18C03_40940	COG3107	peptidoglycan biosynthetic process
WP2S18C03_40950	COG0792	nuclease activity
WP2S18C03_40960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP2S18C03_40980	COG2969	positive regulation of protein catabolic process
WP2S18C03_40990	COG0625	glutathione transferase activity
WP2S18C03_41000	COG2857	Cytochrome c1
WP2S18C03_41010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP2S18C03_41020	COG0723	plastoquinol--plastocyanin reductase activity
WP2S18C03_41030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP2S18C03_41040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP2S18C03_41050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP2S18C03_41070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2S18C03_41080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP2S18C03_41140	COG3964	amidohydrolase
WP2S18C03_41170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_41170	COG3711	transcriptional antiterminator
WP2S18C03_41180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_41190	COG1660	Displays ATPase and GTPase activities
WP2S18C03_41200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_41220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP2S18C03_41230	COG1137	ATPase activity
WP2S18C03_41240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP2S18C03_41260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP2S18C03_41270	COG0517	IMP dehydrogenase activity
WP2S18C03_41270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP2S18C03_41280	COG1127	ABC transporter
WP2S18C03_41290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP2S18C03_41300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP2S18C03_41310	COG2854	intermembrane phospholipid transfer
WP2S18C03_41330	COG5007	Belongs to the BolA IbaG family
WP2S18C03_41340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP2S18C03_41350	COG0312	modulator of DNA gyrase
WP2S18C03_41360	COG3028	Belongs to the UPF0307 family
WP2S18C03_41370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP2S18C03_41390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP2S18C03_41400	COG1011	Hydrolase
WP2S18C03_41430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP2S18C03_41440	COG0019	diaminopimelate decarboxylase activity
WP2S18C03_41450	COG1965	Belongs to the frataxin family
WP2S18C03_41460	COG0400	carboxylic ester hydrolase activity
WP2S18C03_41470	COG3072	Adenylate cyclase
WP2S18C03_41490	COG0181	hydroxymethylbilane synthase activity
WP2S18C03_41510	COG2959	enzyme of heme biosynthesis
WP2S18C03_41540	COG1494	fructose-1,6-bisphosphatase
WP2S18C03_41590	COG1686	Belongs to the peptidase S11 family
WP2S18C03_41610	COG4584	PFAM Integrase catalytic
WP2S18C03_41620	COG1484	DNA-dependent DNA replication
WP2S18C03_41650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP2S18C03_41670	COG3078	GTPase activator activity
WP2S18C03_41690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP2S18C03_41710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP2S18C03_41720	COG0408	coproporphyrinogen oxidase activity
WP2S18C03_41730	COG0009	L-threonylcarbamoyladenylate synthase
WP2S18C03_41750	COG0551	DNA topoisomerase type I activity
WP2S18C03_41760	COG2922	Belongs to the Smg family
WP2S18C03_41770	COG0758	DNA mediated transformation
WP2S18C03_41780	COG1652	LysM domain
WP2S18C03_41790	COG0242	peptide deformylase activity
WP2S18C03_41800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP2S18C03_41810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP2S18C03_41810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP2S18C03_41820	COG0569	domain protein
WP2S18C03_41830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2S18C03_41850	COG0174	glutamine synthetase
WP2S18C03_41890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP2S18C03_41900	COG1322	Protein conserved in bacteria
WP2S18C03_41940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP2S18C03_41950	COG0583	DNA-binding transcription factor activity
WP2S18C03_41960	COG0519	Catalyzes the synthesis of GMP from XMP
WP2S18C03_41960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP2S18C03_41990	COG1396	sequence-specific DNA binding
WP2S18C03_42000	COG1012	belongs to the aldehyde dehydrogenase family
WP2S18C03_42020	COG2962	Rard protein
WP2S18C03_42030	COG0840	transmembrane signaling receptor activity
WP2S18C03_42040	COG2391	methyltransferase activity
WP2S18C03_42080	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP2S18C03_42100	COG3681	Belongs to the UPF0597 family
WP2S18C03_42120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP2S18C03_42130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP2S18C03_42140	COG1979	alcohol dehydrogenase
WP2S18C03_42150	COG2207	Transcriptional regulator
WP2S18C03_42160	COG3040	lipid binding
WP2S18C03_42190	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
WP2S18C03_42230	COG0583	DNA-binding transcription factor activity
WP2S18C03_42240	COG0688	phosphatidylethanolamine metabolic process
WP2S18C03_42260	COG0540	Belongs to the ATCase OTCase family
WP2S18C03_42270	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP2S18C03_42280	COG1438	arginine binding
WP2S18C03_42290	COG3385	transposase activity
WP2S18C03_42300	COG3385	transposase activity
WP2S18C03_42370	COG1401	restriction endodeoxyribonuclease activity
WP2S18C03_42380	COG1401	restriction endodeoxyribonuclease activity
WP2S18C03_42390	COG4584	PFAM Integrase catalytic
WP2S18C03_42400	COG1484	DNA-dependent DNA replication
WP2S18C03_42410	COG1401	restriction endodeoxyribonuclease activity
WP2S18C03_42450	COG0129	dihydroxy-acid dehydratase activity
WP2S18C03_42470	COG3978	acetolactate synthase activity
WP2S18C03_42490	COG0606	chelatase, subunit chli
WP2S18C03_42500	COG0204	Acyl-transferase
WP2S18C03_42510	COG0204	Acyl-transferase
WP2S18C03_42520	COG1683	Conserved Protein
WP2S18C03_42540	COG1335	isochorismatase
WP2S18C03_42560	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP2S18C03_42570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP2S18C03_42590	COG3084	Protein conserved in bacteria
WP2S18C03_42600	COG4251	negative regulation of phosphorylation
WP2S18C03_42600	COG3706	GGDEF domain
WP2S18C03_42600	COG5001	Diguanylate cyclase
WP2S18C03_42600	COG2203	Gaf domain
WP2S18C03_42630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP2S18C03_42640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP2S18C03_42650	COG1561	YicC-like family, N-terminal region
WP2S18C03_42660	COG0583	DNA-binding transcription factor activity
WP2S18C03_42690	COG0583	DNA-binding transcription factor activity
WP2S18C03_42770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP2S18C03_42780	COG0385	Bile acid
WP2S18C03_42790	COG0531	amino acid
WP2S18C03_42800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP2S18C03_42810	COG0531	amino acid
WP2S18C03_42820	COG2731	YhcH YjgK YiaL family protein
WP2S18C03_42830	COG3250	beta-galactosidase activity
WP2S18C03_42840	COG1609	Transcriptional regulator
WP2S18C03_42850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP2S18C03_42860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2S18C03_42860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP2S18C03_42870	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP2S18C03_42890	COG3074	FtsZ-dependent cytokinesis
WP2S18C03_42910	COG1045	serine acetyltransferase
WP2S18C03_42930	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_42940	COG2205	protein histidine kinase activity
WP2S18C03_42950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP2S18C03_42960	COG0534	Mate efflux family protein
WP2S18C03_42990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP2S18C03_43000	COG2937	Belongs to the GPAT DAPAT family
WP2S18C03_43010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP2S18C03_43020	COG3161	chorismate lyase activity
WP2S18C03_43030	COG1580	Controls the rotational direction of flagella during chemotaxis
WP2S18C03_43070	COG0604	alcohol dehydrogenase
WP2S18C03_43080	COG1609	Transcriptional regulator
WP2S18C03_43090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP2S18C03_43120	COG1519	Transferase
WP2S18C03_43130	COG0859	PFAM glycosyl transferase family 9
WP2S18C03_43140	COG0463	Glycosyl transferase, family 2
WP2S18C03_43150	COG0859	PFAM glycosyl transferase family 9
WP2S18C03_43160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP2S18C03_43170	COG2990	Protein conserved in bacteria
WP2S18C03_43180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP2S18C03_43200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP2S18C03_43210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP2S18C03_43220	COG2003	Belongs to the UPF0758 family
WP2S18C03_43230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP2S18C03_43240	COG0756	dUTP diphosphatase activity
WP2S18C03_43250	COG1309	transcriptional regulator
WP2S18C03_43260	COG0668	transmembrane transport
WP2S18C03_43270	COG0166	Belongs to the GPI family
WP2S18C03_43280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP2S18C03_43360	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP2S18C03_43370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP2S18C03_43380	COG1739	Uncharacterized protein family UPF0029
WP2S18C03_43390	COG0006	proline dipeptidase activity
WP2S18C03_43400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2S18C03_43410	COG4584	PFAM Integrase catalytic
WP2S18C03_43420	COG1484	DNA-dependent DNA replication
WP2S18C03_43430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP2S18C03_43440	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP2S18C03_43440	COG1024	Enoyl-CoA hydratase
WP2S18C03_43450	COG0183	Belongs to the thiolase family
WP2S18C03_43460	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_43470	COG2205	protein histidine kinase activity
WP2S18C03_43500	COG0425	Belongs to the sulfur carrier protein TusA family
WP2S18C03_43510	COG0251	oxidation-reduction process
WP2S18C03_43520	COG2885	chlorophyll binding
WP2S18C03_43530	COG0840	transmembrane signaling receptor activity
WP2S18C03_43540	COG2818	Glycosylase
WP2S18C03_43550	COG0752	glycyl-tRNA synthetase alpha subunit
WP2S18C03_43560	COG0751	glycine-tRNA ligase activity
WP2S18C03_43590	COG2203	Gaf domain
WP2S18C03_43590	COG3706	GGDEF domain
WP2S18C03_43590	COG5001	Diguanylate cyclase
WP2S18C03_43590	COG4251	negative regulation of phosphorylation
WP2S18C03_43680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP2S18C03_43710	COG2960	long-chain fatty acid transporting porin activity
WP2S18C03_43720	COG5001	Diguanylate cyclase
WP2S18C03_43720	COG5002	protein histidine kinase activity
WP2S18C03_43740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP2S18C03_43770	COG3118	belongs to the thioredoxin family
WP2S18C03_43780	COG0513	Belongs to the DEAD box helicase family
WP2S18C03_43790	COG0248	Ppx GppA phosphatase
WP2S18C03_43810	COG0742	ribosomal rna small subunit methyltransferase
WP2S18C03_43820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP2S18C03_43850	COG3469	chitinase activity
WP2S18C03_43870	COG0084	hydrolase, TatD family'
WP2S18C03_43880	COG0805	protein transport
WP2S18C03_43890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP2S18C03_43910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP2S18C03_43930	COG2226	methyltransferase
WP2S18C03_43940	COG0402	S-adenosylhomocysteine deaminase activity
WP2S18C03_43950	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP2S18C03_43980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP2S18C03_44010	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP2S18C03_44020	COG0848	biopolymer transport protein
WP2S18C03_44030	COG0811	peptide transport
WP2S18C03_44040	COG0811	peptide transport
WP2S18C03_44070	COG2771	luxR family
WP2S18C03_44080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP2S18C03_44090	COG1349	DNA-binding transcription factor activity
WP2S18C03_44100	COG0745	RESPONSE REGULATOR receiver
WP2S18C03_44110	COG2205	protein histidine kinase activity
WP2S18C03_44140	COG4452	Inner membrane protein CreD
WP2S18C03_44150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP2S18C03_44160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP2S18C03_44170	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP2S18C03_44180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP2S18C03_44190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP2S18C03_44200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP2S18C03_44210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP2S18C03_44230	COG0356	it plays a direct role in the translocation of protons across the membrane
WP2S18C03_44250	COG1475	DNA binding
WP2S18C03_44260	COG1192	Involved in chromosome partitioning
WP2S18C03_44270	COG0357	Ribosomal RNA small subunit methyltransferase G
WP2S18C03_44280	COG0445	tRNA wobble uridine modification
WP2S18C03_44290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP2S18C03_44310	COG3550	peptidyl-serine autophosphorylation
WP2S18C03_44440	COG3385	transposase activity
WP2S18C03_44480	COG4974	Belongs to the 'phage' integrase family
WP2S18C03_44490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP2S18C03_44500	COG0706	membrane insertase activity
WP2S18C03_44510	COG0594	ribonuclease P activity
WP2S18C03_44520	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP2S18C03_P10130	COG5433	transposase activity
WP2S18C03_P10140	COG0358	DNA primase activity
WP2S18C03_P10170	COG3041	Addiction module toxin RelE StbE family
WP2S18C03_P10180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_P10210	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_P10240	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2S18C03_P10270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP2S18C03_P10280	COG3077	Addiction module antitoxin, RelB DinJ family
WP2S18C03_P10310	COG5433	transposase activity
WP2S18C03_P10360	COG2194	sulfuric ester hydrolase activity
WP2S18C03_P10420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP2S18C03_P10560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP2S18C03_P10630	COG3293	Transposase
WP2S18C03_P10650	COG1475	DNA binding
WP2S18C03_P10660	COG0556	nucleotide-excision repair
WP2S18C03_P10730	COG1702	phosphate starvation-inducible protein PhoH
WP2S18C03_P10750	COG4974	Belongs to the 'phage' integrase family
WP2S18C03_P20040	COG3041	Addiction module toxin RelE StbE family
WP2S18C03_P20050	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP2S18C03_P20070	COG1357	PFAM Pentapeptide repeats (8 copies)
WP2S18C03_P20130	COG1192	Involved in chromosome partitioning
WP2S18C03_P30150	COG2194	sulfuric ester hydrolase activity