locus-tag	class	description
WP8S18E11_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP8S18E11_00020	COG0592	DNA-directed DNA polymerase activity
WP8S18E11_00040	COG0187	DNA topoisomerase II activity
WP8S18E11_00070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP8S18E11_00080	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S18E11_00090	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8S18E11_00100	COG3977	Valine--pyruvate aminotransferase
WP8S18E11_00130	COG2814	Major facilitator Superfamily
WP8S18E11_00140	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_00150	COG2205	protein histidine kinase activity
WP8S18E11_00190	COG1733	regulation of RNA biosynthetic process
WP8S18E11_00210	COG0604	alcohol dehydrogenase
WP8S18E11_00230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S18E11_00240	COG4191	Histidine kinase
WP8S18E11_00240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_00250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E11_00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_00270	COG1309	transcriptional regulator
WP8S18E11_00290	COG0469	pyruvate kinase activity
WP8S18E11_00300	COG2271	Major facilitator Superfamily
WP8S18E11_00350	COG0561	phosphatase activity
WP8S18E11_00360	COG2267	carboxylic ester hydrolase activity
WP8S18E11_00370	COG0110	maltose O-acetyltransferase activity
WP8S18E11_00380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S18E11_00390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S18E11_00400	COG1758	RNA polymerase activity
WP8S18E11_00410	COG0194	GDP metabolic process
WP8S18E11_00420	COG0859	PFAM glycosyl transferase family 9
WP8S18E11_00430	COG3642	lipopolysaccharide core region biosynthetic process
WP8S18E11_00510	COG0589	response to stress
WP8S18E11_00520	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8S18E11_00530	COG1528	Iron-storage protein
WP8S18E11_00540	COG2081	HI0933 family
WP8S18E11_00550	COG3275	phosphorelay sensor kinase activity
WP8S18E11_00560	COG3279	Response regulator of the LytR AlgR family
WP8S18E11_00570	COG2223	nitrite transmembrane transporter activity
WP8S18E11_00580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP8S18E11_00590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP8S18E11_00620	COG0583	DNA-binding transcription factor activity
WP8S18E11_00670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP8S18E11_00680	COG2166	iron-sulfur cluster assembly
WP8S18E11_00690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP8S18E11_00720	COG3245	cytochrome
WP8S18E11_00730	COG1063	alcohol dehydrogenase
WP8S18E11_00760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S18E11_00790	COG3307	-O-antigen
WP8S18E11_00800	COG3306	glycosyltransferase involved in LPS biosynthesis
WP8S18E11_00870	COG1280	lysine exporter protein (LysE YggA)
WP8S18E11_00950	COG1943	Transposase
WP8S18E11_00960	COG0210	DNA helicase
WP8S18E11_01010	COG2239	Acts as a magnesium transporter
WP8S18E11_01020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E11_01020	COG1648	precorrin-2 dehydrogenase activity
WP8S18E11_01030	COG2116	formate transmembrane transporter activity
WP8S18E11_01050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E11_01060	COG0842	Transport permease protein
WP8S18E11_01070	COG0842	Transport permease protein
WP8S18E11_01080	COG1131	(ABC) transporter
WP8S18E11_01090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_01130	COG0477	Major facilitator Superfamily
WP8S18E11_01140	COG3385	transposase activity
WP8S18E11_01150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP8S18E11_01160	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP8S18E11_01180	COG0018	arginyl-trna synthetase
WP8S18E11_01200	COG1595	DNA-templated transcription, initiation
WP8S18E11_01220	COG1968	undecaprenyl-diphosphatase activity
WP8S18E11_01230	COG2017	converts alpha-aldose to the beta-anomer
WP8S18E11_01240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8S18E11_01250	COG1085	galactose-1-phosphate uridylyltransferase
WP8S18E11_01260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E11_01270	COG1609	Transcriptional regulator
WP8S18E11_01280	COG3250	beta-galactosidase activity
WP8S18E11_01310	COG4211	Belongs to the binding-protein-dependent transport system permease family
WP8S18E11_01330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E11_01360	COG0366	Alpha amylase catalytic
WP8S18E11_01390	COG0443	Heat shock 70 kDa protein
WP8S18E11_01400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S18E11_01410	COG3045	CreA protein
WP8S18E11_01450	COG0174	glutamine synthetase
WP8S18E11_01490	COG3842	ATPase activity
WP8S18E11_01500	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S18E11_01510	COG1177	transmembrane transport
WP8S18E11_01520	COG2258	MOSC domain
WP8S18E11_01580	COG0732	type I restriction modification DNA specificity domain
WP8S18E11_01690	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S18E11_01700	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E11_01710	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E11_01730	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP8S18E11_01750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP8S18E11_01760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S18E11_01790	COG0254	rRNA binding
WP8S18E11_01800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP8S18E11_01820	COG0702	epimerase
WP8S18E11_01830	COG0814	amino acid
WP8S18E11_01840	COG0281	malic enzyme
WP8S18E11_01850	COG1295	ribonuclease BN
WP8S18E11_01860	COG1490	D-aminoacyl-tRNA deacylase activity
WP8S18E11_01870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WP8S18E11_01890	COG0456	acetyltransferase
WP8S18E11_01910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP8S18E11_01920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S18E11_01930	COG2610	gluconate transmembrane transporter activity
WP8S18E11_01940	COG3265	gluconokinase activity
WP8S18E11_01950	COG0129	dihydroxy-acid dehydratase activity
WP8S18E11_01960	COG0800	Aldolase
WP8S18E11_01970	COG1609	Transcriptional regulator
WP8S18E11_01990	COG4942	peptidase
WP8S18E11_02000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP8S18E11_02010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E11_02020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP8S18E11_02030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP8S18E11_02040	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP8S18E11_02040	COG0316	Belongs to the HesB IscA family
WP8S18E11_02050	COG1040	competence protein
WP8S18E11_02060	COG0596	Alpha beta hydrolase
WP8S18E11_02100	COG2183	response to ionizing radiation
WP8S18E11_02110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S18E11_02120	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_02150	COG0051	transcription antitermination factor activity, RNA binding
WP8S18E11_02160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP8S18E11_02170	COG0088	Forms part of the polypeptide exit tunnel
WP8S18E11_02180	COG0089	rRNA binding
WP8S18E11_02190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP8S18E11_02200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP8S18E11_02210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP8S18E11_02220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP8S18E11_02230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP8S18E11_02240	COG0255	Belongs to the universal ribosomal protein uL29 family
WP8S18E11_02250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP8S18E11_02260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP8S18E11_02270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP8S18E11_02280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP8S18E11_02290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP8S18E11_02300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP8S18E11_02310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP8S18E11_02320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WP8S18E11_02330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP8S18E11_02340	COG1841	ribosomal large subunit assembly
WP8S18E11_02350	COG0200	Binds to the 23S rRNA
WP8S18E11_02360	COG0201	protein transport
WP8S18E11_02370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP8S18E11_02380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP8S18E11_02390	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP8S18E11_02400	COG0202	RNA polymerase activity
WP8S18E11_02410	COG0203	ribosomal protein L17
WP8S18E11_02470	COG3714	YhhN family
WP8S18E11_02520	COG1301	dicarboxylic acid transport
WP8S18E11_02540	COG2095	MarC family integral membrane protein
WP8S18E11_02550	COG0583	DNA-binding transcription factor activity
WP8S18E11_02580	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S18E11_02600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S18E11_02630	COG1770	oligopeptidase
WP8S18E11_02660	COG4221	oxidoreductase activity
WP8S18E11_02670	COG0583	DNA-binding transcription factor activity
WP8S18E11_02680	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8S18E11_02730	COG0742	ribosomal rna small subunit methyltransferase
WP8S18E11_02740	COG0552	protein localization to endoplasmic reticulum
WP8S18E11_02750	COG2884	Cell division ATP-binding protein ftsE
WP8S18E11_02760	COG2177	Part of the ABC transporter FtsEX involved in
WP8S18E11_02780	COG0288	reversible hydration of carbon dioxide
WP8S18E11_02790	COG2188	Transcriptional regulator
WP8S18E11_02800	COG1228	amidohydrolase
WP8S18E11_02810	COG0010	Belongs to the arginase family
WP8S18E11_02820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP8S18E11_02830	COG2986	histidine ammonia-lyase
WP8S18E11_02840	COG0387	Pfam Sodium calcium exchanger
WP8S18E11_02850	COG2200	EAL domain
WP8S18E11_02860	COG2199	diguanylate cyclase activity
WP8S18E11_02860	COG2200	EAL domain
WP8S18E11_02950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S18E11_02960	COG3941	tape measure
WP8S18E11_02970	COG4397	Mu-like prophage major head subunit gpT
WP8S18E11_03060	COG1459	type II secretion system
WP8S18E11_03100	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8S18E11_03150	COG1077	Cell shape determining protein MreB Mrl
WP8S18E11_03160	COG1792	Involved in formation and maintenance of cell shape
WP8S18E11_03170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP8S18E11_03180	COG0424	maF-like protein
WP8S18E11_03190	COG1530	ribonuclease E activity
WP8S18E11_03200	COG3164	Protein of unknown function
WP8S18E11_03220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S18E11_03230	COG0312	modulator of DNA gyrase
WP8S18E11_03270	COG0477	Major facilitator Superfamily
WP8S18E11_03360	COG0189	ligase activity
WP8S18E11_03370	COG0642	Histidine kinase
WP8S18E11_03380	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_03410	COG0789	Transcriptional regulator
WP8S18E11_03420	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP8S18E11_03430	COG0352	thiamine-phosphate diphosphorylase activity
WP8S18E11_03440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S18E11_03460	COG2022	thiamine diphosphate biosynthetic process
WP8S18E11_03470	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S18E11_03490	COG0110	maltose O-acetyltransferase activity
WP8S18E11_03520	COG0814	amino acid
WP8S18E11_03530	COG3932	Exopolysaccharide synthesis, ExoD
WP8S18E11_03550	COG3706	GGDEF domain
WP8S18E11_03560	COG0004	ammonium transporteR
WP8S18E11_03570	COG3133	Outer membrane lipoprotein
WP8S18E11_03580	COG0456	acetyltransferase
WP8S18E11_03630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP8S18E11_03660	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E11_03670	COG0628	permease
WP8S18E11_03700	COG2957	Belongs to the agmatine deiminase family
WP8S18E11_03710	COG0583	DNA-binding transcription factor activity
WP8S18E11_03740	COG2801	Transposase and inactivated derivatives
WP8S18E11_03760	COG3284	Transcriptional regulator
WP8S18E11_03780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP8S18E11_03780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_03780	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
WP8S18E11_03790	COG1461	Dihydroxyacetone kinase
WP8S18E11_03800	COG2376	Dihydroxyacetone kinase
WP8S18E11_03810	COG2252	PERMEase
WP8S18E11_03820	COG1278	Cold shock
WP8S18E11_03840	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WP8S18E11_03890	COG2197	response regulator
WP8S18E11_03960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP8S18E11_03970	COG3706	GGDEF domain
WP8S18E11_03990	COG3047	cAMP biosynthetic process
WP8S18E11_04000	COG3385	transposase activity
WP8S18E11_04010	COG0840	transmembrane signaling receptor activity
WP8S18E11_04060	COG3135	benzoate transporter
WP8S18E11_04070	COG1396	sequence-specific DNA binding
WP8S18E11_04100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S18E11_04100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8S18E11_04130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP8S18E11_04140	COG0038	chloride channel
WP8S18E11_04160	COG0316	Belongs to the HesB IscA family
WP8S18E11_04170	COG1757	Na H antiporter
WP8S18E11_04200	COG0297	glycogen (starch) synthase activity
WP8S18E11_04210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP8S18E11_04220	COG2813	Specifically methylates the guanine in position
WP8S18E11_04230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S18E11_04250	COG1392	Phosphate transport regulator
WP8S18E11_04260	COG0306	phosphate transporter
WP8S18E11_04270	COG0527	aspartate kinase activity
WP8S18E11_04270	COG0460	homoserine dehydrogenase
WP8S18E11_04280	COG0626	cystathionine gamma-synthase activity
WP8S18E11_04300	COG0814	amino acid
WP8S18E11_04310	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP8S18E11_04320	COG0494	nUDIX hydrolase
WP8S18E11_04330	COG1011	Hydrolase
WP8S18E11_04360	COG0110	maltose O-acetyltransferase activity
WP8S18E11_04370	COG3174	membrane
WP8S18E11_04380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP8S18E11_04400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP8S18E11_04410	COG4208	sulfate ABC transporter
WP8S18E11_04420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP8S18E11_04430	COG0583	DNA-binding transcription factor activity
WP8S18E11_04440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S18E11_04450	COG0765	amino acid transport
WP8S18E11_04480	COG1126	abc transporter atp-binding protein
WP8S18E11_04490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_04500	COG3397	chitin binding
WP8S18E11_04510	COG0840	transmembrane signaling receptor activity
WP8S18E11_04570	COG0633	Ferredoxin
WP8S18E11_04570	COG0543	2 iron, 2 sulfur cluster binding
WP8S18E11_04600	COG1328	CTP reductase activity
WP8S18E11_04610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S18E11_04640	COG1448	Aminotransferase
WP8S18E11_04650	COG2194	sulfuric ester hydrolase activity
WP8S18E11_04680	COG1215	transferase activity, transferring glycosyl groups
WP8S18E11_04700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
WP8S18E11_04710	COG3118	belongs to the thioredoxin family
WP8S18E11_04710	COG0457	Tetratricopeptide repeat
WP8S18E11_04780	COG3385	transposase activity
WP8S18E11_04800	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_04850	COG3112	Uncharacterised protein family (UPF0231)
WP8S18E11_04870	COG3835	regulator
WP8S18E11_04880	COG2610	gluconate transmembrane transporter activity
WP8S18E11_04890	COG1929	Belongs to the glycerate kinase type-1 family
WP8S18E11_04930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E11_04950	COG1872	DUF167
WP8S18E11_04960	COG0762	integral membrane protein
WP8S18E11_04970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP8S18E11_04980	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP8S18E11_05010	COG3022	response to hydroperoxide
WP8S18E11_05050	COG0347	Belongs to the P(II) protein family
WP8S18E11_05060	COG1840	ABC-type Fe3 transport system, periplasmic component
WP8S18E11_05080	COG3842	ATPase activity
WP8S18E11_05090	COG2837	iron assimilation
WP8S18E11_05100	COG1438	arginine binding
WP8S18E11_05110	COG1126	abc transporter atp-binding protein
WP8S18E11_05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_05130	COG4215	(ABC) transporter
WP8S18E11_05140	COG4160	amino acid transport
WP8S18E11_05150	COG0039	L-malate dehydrogenase activity
WP8S18E11_05160	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP8S18E11_05170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E11_05170	COG1017	nitric oxide dioxygenase activity
WP8S18E11_05190	COG4536	flavin adenine dinucleotide binding
WP8S18E11_05200	COG4137	Cytochrome C assembly protein
WP8S18E11_05210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP8S18E11_05220	COG0228	four-way junction DNA binding
WP8S18E11_05230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP8S18E11_05240	COG0336	Belongs to the RNA methyltransferase TrmD family
WP8S18E11_05250	COG0335	large ribosomal subunit rRNA binding
WP8S18E11_05270	COG3066	DNA modification
WP8S18E11_05280	COG1051	belongs to the nudix hydrolase family
WP8S18E11_05300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP8S18E11_05310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP8S18E11_05320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S18E11_05340	COG0583	DNA-binding transcription factor activity
WP8S18E11_05350	COG0640	Transcriptional regulator
WP8S18E11_05360	COG0268	Binds directly to 16S ribosomal RNA
WP8S18E11_05370	COG0728	peptidoglycan biosynthetic process
WP8S18E11_05380	COG0196	riboflavin kinase activity
WP8S18E11_05390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP8S18E11_05400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP8S18E11_05410	COG1047	Peptidyl-prolyl cis-trans
WP8S18E11_05420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP8S18E11_05430	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8S18E11_05440	COG3039	Transposase
WP8S18E11_05520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8S18E11_05520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP8S18E11_05550	COG1854	S-ribosylhomocysteine lyase activity
WP8S18E11_05580	COG0084	hydrolase, TatD family'
WP8S18E11_05590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E11_05610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP8S18E11_05620	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP8S18E11_05630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP8S18E11_05670	COG0560	Phosphoserine phosphatase
WP8S18E11_05700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP8S18E11_05710	COG3385	transposase activity
WP8S18E11_05740	COG0776	regulation of translation
WP8S18E11_05760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8S18E11_05770	COG1914	H( )-stimulated, divalent metal cation uptake system
WP8S18E11_05780	COG0360	Binds together with S18 to 16S ribosomal RNA
WP8S18E11_05790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP8S18E11_05800	COG0359	binds to the 23S rRNA
WP8S18E11_05810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E11_05850	COG1064	alcohol dehydrogenase
WP8S18E11_05860	COG1238	metal cluster binding
WP8S18E11_05870	COG0612	Peptidase, M16
WP8S18E11_05880	COG2918	glutathione biosynthetic process
WP8S18E11_05900	COG3385	transposase activity
WP8S18E11_05910	COG1022	Amp-dependent synthetase and ligase
WP8S18E11_05930	COG0456	acetyltransferase
WP8S18E11_05980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
WP8S18E11_06020	COG0477	Major facilitator Superfamily
WP8S18E11_06030	COG0583	DNA-binding transcription factor activity
WP8S18E11_06040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E11_06050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E11_06070	COG0673	inositol 2-dehydrogenase activity
WP8S18E11_06090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP8S18E11_06100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8S18E11_06110	COG3036	rescue of stalled ribosome
WP8S18E11_06130	COG0138	bifunctional purine biosynthesis protein purh
WP8S18E11_06140	COG0151	Belongs to the GarS family
WP8S18E11_06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP8S18E11_06250	COG0358	DNA primase activity
WP8S18E11_06260	COG1610	YqeY-like protein
WP8S18E11_06270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP8S18E11_06280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP8S18E11_06290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S18E11_06300	COG1027	Aspartate ammonia-lyase
WP8S18E11_06310	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP8S18E11_06320	COG0534	Mate efflux family protein
WP8S18E11_06330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP8S18E11_06340	COG0459	protein refolding
WP8S18E11_06410	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP8S18E11_06420	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP8S18E11_06440	COG4143	(ABC) transporter
WP8S18E11_06470	COG0066	3-isopropylmalate dehydratase activity
WP8S18E11_06480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP8S18E11_06490	COG0473	3-isopropylmalate dehydrogenase activity
WP8S18E11_06500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8S18E11_06520	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E11_06550	COG0028	Belongs to the TPP enzyme family
WP8S18E11_06570	COG0440	acetolactate synthase activity
WP8S18E11_06680	COG3311	Transcriptional regulator
WP8S18E11_06840	COG2003	Belongs to the UPF0758 family
WP8S18E11_06950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8S18E11_06980	COG2189	Belongs to the N(4) N(6)-methyltransferase family
WP8S18E11_07000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP8S18E11_07010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E11_07030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_07090	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_07100	COG3104	oligopeptide transport
WP8S18E11_07110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP8S18E11_07120	COG1555	photosystem II stabilization
WP8S18E11_07130	COG0280	phosphate acetyltransferase
WP8S18E11_07130	COG0857	belongs to the CobB CobQ family
WP8S18E11_07140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8S18E11_07160	COG3013	Belongs to the UPF0304 family
WP8S18E11_07180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP8S18E11_07190	COG2716	regulation of RNA biosynthetic process
WP8S18E11_07200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8S18E11_07210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP8S18E11_07220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP8S18E11_07290	COG5002	protein histidine kinase activity
WP8S18E11_07290	COG2198	Histidine kinase
WP8S18E11_07290	COG0784	Response regulator, receiver
WP8S18E11_07300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WP8S18E11_07320	COG5002	protein histidine kinase activity
WP8S18E11_07320	COG2205	protein histidine kinase activity
WP8S18E11_07320	COG0784	Response regulator, receiver
WP8S18E11_07360	COG1464	Belongs to the NlpA lipoprotein family
WP8S18E11_07370	COG2011	ABC-type metal ion transport system permease component
WP8S18E11_07420	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP8S18E11_07420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP8S18E11_07430	COG0802	atpase or kinase
WP8S18E11_07450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP8S18E11_07460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP8S18E11_07470	COG1923	regulation of RNA biosynthetic process
WP8S18E11_07480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP8S18E11_07490	COG0330	HflC and HflK could
WP8S18E11_07500	COG0330	HflC and HflK could
WP8S18E11_07510	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP8S18E11_07530	COG0142	geranyltranstransferase activity
WP8S18E11_07540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP8S18E11_07550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP8S18E11_07560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP8S18E11_07580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP8S18E11_07600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8S18E11_07610	COG2967	ApaG domain
WP8S18E11_07620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP8S18E11_07630	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP8S18E11_07640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S18E11_07650	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP8S18E11_07660	COG3178	'Phosphotransferase
WP8S18E11_07670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP8S18E11_07680	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S18E11_07690	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S18E11_07750	COG2801	Transposase and inactivated derivatives
WP8S18E11_07770	COG0840	transmembrane signaling receptor activity
WP8S18E11_07820	COG1136	(ABC) transporter
WP8S18E11_07850	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP8S18E11_07880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP8S18E11_07890	COG0784	Response regulator, receiver
WP8S18E11_07890	COG3437	response regulator, receiver
WP8S18E11_07900	COG0583	DNA-binding transcription factor activity
WP8S18E11_07910	COG2076	Multidrug Resistance protein
WP8S18E11_07920	COG2076	Multidrug Resistance protein
WP8S18E11_07930	COG0346	lactoylglutathione lyase activity
WP8S18E11_07940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S18E11_07950	COG1643	Atp-dependent helicase
WP8S18E11_07970	COG1489	DNA binding
WP8S18E11_07980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP8S18E11_07990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E11_08000	COG0617	tRNA 3'-terminal CCA addition
WP8S18E11_08010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP8S18E11_08020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP8S18E11_08030	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP8S18E11_08080	COG1486	melibiose metabolic process
WP8S18E11_08100	COG1129	ABC transporter
WP8S18E11_08130	COG1924	4 iron, 4 sulfur cluster binding
WP8S18E11_08140	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WP8S18E11_08150	COG0842	Transport permease protein
WP8S18E11_08160	COG1131	(ABC) transporter
WP8S18E11_08190	COG0163	prenyltransferase activity
WP8S18E11_08200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S18E11_08210	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E11_08220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E11_08230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E11_08240	COG1151	hydroxylamine reductase activity
WP8S18E11_08250	COG0783	Belongs to the Dps family
WP8S18E11_08260	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP8S18E11_08270	COG4807	Protein conserved in bacteria
WP8S18E11_08290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E11_08300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8S18E11_08310	COG3956	TIGRFAM MazG family protein
WP8S18E11_08320	COG0504	CTP synthase activity
WP8S18E11_08330	COG0148	phosphopyruvate hydratase activity
WP8S18E11_08410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP8S18E11_08430	COG0488	(ABC) transporter
WP8S18E11_08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E11_08500	COG1794	racemase activity, acting on amino acids and derivatives
WP8S18E11_08520	COG2731	YhcH YjgK YiaL family protein
WP8S18E11_08540	COG0668	transmembrane transport
WP8S18E11_08550	COG1376	ErfK ybiS ycfS ynhG family protein
WP8S18E11_08570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S18E11_08580	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP8S18E11_08590	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP8S18E11_08610	COG0585	pseudouridine synthase activity
WP8S18E11_08620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP8S18E11_08630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP8S18E11_08640	COG1238	metal cluster binding
WP8S18E11_08670	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E11_08700	COG2957	Belongs to the agmatine deiminase family
WP8S18E11_08710	COG0154	amidase activity
WP8S18E11_08760	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_08770	COG2203	Gaf domain
WP8S18E11_08770	COG2199	diguanylate cyclase activity
WP8S18E11_08790	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP8S18E11_08800	COG1858	cytochrome C peroxidase
WP8S18E11_08890	COG2188	Transcriptional regulator
WP8S18E11_08920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP8S18E11_08930	COG4608	Belongs to the ABC transporter superfamily
WP8S18E11_08940	COG0444	Belongs to the ABC transporter superfamily
WP8S18E11_08960	COG4239	(ABC) transporter, permease
WP8S18E11_08970	COG4174	ABC transporter (Permease)
WP8S18E11_09000	COG0811	peptide transport
WP8S18E11_09010	COG0811	peptide transport
WP8S18E11_09020	COG0848	biopolymer transport protein
WP8S18E11_09060	COG0616	signal peptide processing
WP8S18E11_09070	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E11_09070	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E11_09080	COG0778	Nitroreductase
WP8S18E11_09100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S18E11_09110	COG2264	protein methyltransferase activity
WP8S18E11_09120	COG0604	alcohol dehydrogenase
WP8S18E11_09130	COG0583	DNA-binding transcription factor activity
WP8S18E11_09140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_09140	COG1263	PTS System
WP8S18E11_09140	COG2190	(PTS) system
WP8S18E11_09150	COG4145	pantothenate transmembrane transporter activity
WP8S18E11_09160	COG3924	membrane
WP8S18E11_09170	COG0439	Biotin carboxylase
WP8S18E11_09180	COG0511	ligase activity, forming carbon-carbon bonds
WP8S18E11_09190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP8S18E11_09200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S18E11_09270	COG3381	protein complex oligomerization
WP8S18E11_09290	COG3005	denitrification pathway
WP8S18E11_09300	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_09320	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E11_09330	COG2205	protein histidine kinase activity
WP8S18E11_09330	COG2198	Histidine kinase
WP8S18E11_09330	COG0784	Response regulator, receiver
WP8S18E11_09350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP8S18E11_09360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP8S18E11_09370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S18E11_09370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8S18E11_09400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP8S18E11_09410	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E11_09420	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP8S18E11_09430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP8S18E11_09480	COG2900	Belongs to the SlyX family
WP8S18E11_09500	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S18E11_09510	COG2204	response regulator
WP8S18E11_09550	COG0737	Belongs to the 5'-nucleotidase family
WP8S18E11_09570	COG3385	transposase activity
WP8S18E11_09590	COG3655	Transcriptional regulator
WP8S18E11_09610	COG0784	Response regulator, receiver
WP8S18E11_09610	COG5002	protein histidine kinase activity
WP8S18E11_09610	COG2205	protein histidine kinase activity
WP8S18E11_09630	COG3706	GGDEF domain
WP8S18E11_09650	COG3397	chitin binding
WP8S18E11_09690	COG0784	Response regulator, receiver
WP8S18E11_09690	COG0835	chemotaxis
WP8S18E11_09700	COG2755	lipolytic protein G-D-S-L family
WP8S18E11_09710	COG4181	ATPase activity
WP8S18E11_09720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP8S18E11_09730	COG1090	epimerase
WP8S18E11_09740	COG2200	EAL domain
WP8S18E11_09750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E11_09760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP8S18E11_09770	COG3171	Protein conserved in bacteria
WP8S18E11_09780	COG2066	Belongs to the glutaminase family
WP8S18E11_09790	COG2897	thiosulfate sulfurtransferase activity
WP8S18E11_09820	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S18E11_09840	COG2966	Psort location CytoplasmicMembrane, score
WP8S18E11_09870	COG4175	Glycine betaine
WP8S18E11_09880	COG4176	ABC-type proline glycine betaine transport system permease component
WP8S18E11_09890	COG2113	Glycine betaine
WP8S18E11_09920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8S18E11_09940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP8S18E11_09950	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP8S18E11_09970	COG5001	Diguanylate cyclase
WP8S18E11_09980	COG0786	glutamate:sodium symporter activity
WP8S18E11_09990	COG0252	asparaginase activity
WP8S18E11_10000	COG3139	Protein of unknown function (DUF1315)
WP8S18E11_10040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP8S18E11_10060	COG0321	lipoyl(octanoyl) transferase activity
WP8S18E11_10070	COG2921	Belongs to the UPF0250 family
WP8S18E11_10080	COG1686	Belongs to the peptidase S11 family
WP8S18E11_10090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP8S18E11_10100	COG2951	lytic endotransglycosylase activity
WP8S18E11_10110	COG0772	Belongs to the SEDS family
WP8S18E11_10120	COG0772	Belongs to the SEDS family
WP8S18E11_10130	COG0768	penicillin binding
WP8S18E11_10140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP8S18E11_10150	COG0799	negative regulation of ribosome biogenesis
WP8S18E11_10160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP8S18E11_10190	COG0495	leucyl-tRNA aminoacylation
WP8S18E11_10200	COG2888	peptidyl-tyrosine sulfation
WP8S18E11_10210	COG0312	modulator of DNA gyrase
WP8S18E11_10230	COG0716	FMN binding
WP8S18E11_10240	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_10250	COG1970	mechanosensitive ion channel activity
WP8S18E11_10280	COG0789	Transcriptional regulator
WP8S18E11_10290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP8S18E11_10300	COG4535	Mg2 and Co2 transporter CorC
WP8S18E11_10310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP8S18E11_10320	COG1702	phosphate starvation-inducible protein PhoH
WP8S18E11_10330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S18E11_10340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E11_10350	COG1335	isochorismatase
WP8S18E11_10380	COG3706	GGDEF domain
WP8S18E11_10390	COG0583	DNA-binding transcription factor activity
WP8S18E11_10430	COG5433	transposase activity
WP8S18E11_10460	COG3385	transposase activity
WP8S18E11_10470	COG1611	Belongs to the LOG family
WP8S18E11_10480	COG3706	GGDEF domain
WP8S18E11_10500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S18E11_10500	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8S18E11_10520	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP8S18E11_10570	COG3098	single-species biofilm formation
WP8S18E11_10580	COG0564	pseudouridine synthase activity
WP8S18E11_10590	COG0716	FMN binding
WP8S18E11_10620	COG1263	PTS System
WP8S18E11_10620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_10640	COG2171	N-acyltransferase activity
WP8S18E11_10650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
WP8S18E11_10660	COG0024	Methionine aminopeptidase
WP8S18E11_10670	COG0052	Belongs to the universal ribosomal protein uS2 family
WP8S18E11_10680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP8S18E11_10690	COG0528	UMP kinase activity
WP8S18E11_10700	COG0233	cytoplasmic translational termination
WP8S18E11_10710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP8S18E11_10720	COG0575	Belongs to the CDS family
WP8S18E11_10730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP8S18E11_10740	COG0750	zinc metalloprotease
WP8S18E11_10770	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E11_10780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S18E11_10790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E11_10800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E11_10810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP8S18E11_10830	COG0825	malonyl-CoA metabolic process
WP8S18E11_10860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8S18E11_10870	COG1115	amino acid carrier protein
WP8S18E11_10900	COG0714	Associated with various cellular activities
WP8S18E11_10970	COG3039	Transposase
WP8S18E11_11000	COG3104	oligopeptide transport
WP8S18E11_11010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP8S18E11_11020	COG1678	Uncharacterized ACR, COG1678
WP8S18E11_11100	COG1846	Transcriptional regulator
WP8S18E11_11120	COG0281	malic enzyme
WP8S18E11_11130	COG3290	protein histidine kinase activity
WP8S18E11_11150	COG0697	spore germination
WP8S18E11_11170	COG0346	lactoylglutathione lyase activity
WP8S18E11_11180	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_11190	COG5002	protein histidine kinase activity
WP8S18E11_11240	COG3142	Participates in the control of copper homeostasis
WP8S18E11_11250	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8S18E11_11300	COG0678	peroxiredoxin activity
WP8S18E11_11320	COG0019	diaminopimelate decarboxylase activity
WP8S18E11_11330	COG1115	amino acid carrier protein
WP8S18E11_11350	COG0095	Lipoate-protein ligase
WP8S18E11_11370	COG2233	PERMEase
WP8S18E11_11380	COG3706	GGDEF domain
WP8S18E11_11400	COG0534	Mate efflux family protein
WP8S18E11_11420	COG0281	malic enzyme
WP8S18E11_11480	COG0733	neurotransmitter:sodium symporter activity
WP8S18E11_11490	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S18E11_11500	COG3706	GGDEF domain
WP8S18E11_11510	COG1566	PFAM secretion protein HlyD family protein
WP8S18E11_11530	COG1032	radical SAM domain protein
WP8S18E11_11550	COG3039	Transposase
WP8S18E11_11590	COG0673	inositol 2-dehydrogenase activity
WP8S18E11_11600	COG2920	part of a sulfur-relay system
WP8S18E11_11610	COG1289	transmembrane transporter activity
WP8S18E11_11620	COG0670	Belongs to the BI1 family
WP8S18E11_11650	COG1486	melibiose metabolic process
WP8S18E11_11660	COG2169	Transcriptional regulator
WP8S18E11_11660	COG1917	Cupin 2, conserved barrel domain protein
WP8S18E11_11670	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP8S18E11_11680	COG2723	6-phospho-beta-galactosidase activity
WP8S18E11_11690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E11_11700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E11_11710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E11_11720	COG1446	asparaginase
WP8S18E11_11740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
WP8S18E11_11750	COG1447	Phosphotransferase system cellobiose-specific component IIA
WP8S18E11_11760	COG3385	transposase activity
WP8S18E11_11790	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP8S18E11_11810	COG3156	type II secretion system protein K
WP8S18E11_11820	COG4795	General secretion pathway protein
WP8S18E11_11830	COG2165	general secretion pathway protein
WP8S18E11_11860	COG2165	general secretion pathway protein
WP8S18E11_11870	COG1459	type II secretion system
WP8S18E11_11880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S18E11_11900	COG3031	protein transport across the cell outer membrane
WP8S18E11_11920	COG3267	Type II secretory pathway component ExeA
WP8S18E11_11920	COG3409	Peptidoglycan-binding domain 1 protein
WP8S18E11_11930	COG2770	Histidine kinase
WP8S18E11_11930	COG3437	response regulator, receiver
WP8S18E11_11960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP8S18E11_11970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP8S18E11_11980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_12000	COG2190	(PTS) system
WP8S18E11_12010	COG3706	GGDEF domain
WP8S18E11_12030	COG1196	nuclear chromosome segregation
WP8S18E11_12030	COG3264	Mechanosensitive ion channel
WP8S18E11_12040	COG0469	pyruvate kinase activity
WP8S18E11_12060	COG3384	dioxygenase
WP8S18E11_12070	COG0419	ATPase involved in DNA repair
WP8S18E11_12080	COG0420	3'-5' exonuclease activity
WP8S18E11_12100	COG2974	May be involved in recombination
WP8S18E11_12120	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP8S18E11_12140	COG0531	amino acid
WP8S18E11_12160	COG0531	amino acid
WP8S18E11_12200	COG1917	Cupin 2, conserved barrel domain protein
WP8S18E11_12200	COG1396	sequence-specific DNA binding
WP8S18E11_12210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E11_12270	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_12290	COG3038	cytochrome b561
WP8S18E11_12300	COG1720	tRNA m6t6A37 methyltransferase activity
WP8S18E11_12340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP8S18E11_12350	COG4988	ABC transporter
WP8S18E11_12360	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_12380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8S18E11_12440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E11_12450	COG1988	membrane-bound metal-dependent
WP8S18E11_12480	COG3385	transposase activity
WP8S18E11_12490	COG0159	tryptophan synthase activity
WP8S18E11_12500	COG0133	tryptophan synthase activity
WP8S18E11_12510	COG0134	indole-3-glycerol-phosphate synthase activity
WP8S18E11_12510	COG0135	phosphoribosylanthranilate isomerase activity
WP8S18E11_12520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S18E11_12530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8S18E11_12530	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8S18E11_12540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP8S18E11_12560	COG0009	L-threonylcarbamoyladenylate synthase
WP8S18E11_12580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP8S18E11_12600	COG1946	Acyl-CoA thioesterase
WP8S18E11_12610	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP8S18E11_12620	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP8S18E11_12640	COG0083	homoserine kinase activity
WP8S18E11_12650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8S18E11_12660	COG3039	Transposase
WP8S18E11_12670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8S18E11_12710	COG3385	transposase activity
WP8S18E11_12720	COG2850	peptidyl-arginine hydroxylation
WP8S18E11_12730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP8S18E11_12740	COG2915	High frequency lysogenization protein hflD homolog
WP8S18E11_12750	COG0482	sulfurtransferase activity
WP8S18E11_12770	COG1187	pseudouridine synthase activity
WP8S18E11_12790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_12830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_12830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_12840	COG0737	Belongs to the 5'-nucleotidase family
WP8S18E11_12910	COG1609	Transcriptional regulator
WP8S18E11_12920	COG1263	PTS System
WP8S18E11_12920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_12930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8S18E11_12940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP8S18E11_12960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E11_12970	COG1960	acyl-CoA dehydrogenase activity
WP8S18E11_12990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP8S18E11_13030	COG3383	formate dehydrogenase (NAD+) activity
WP8S18E11_13050	COG0784	Response regulator, receiver
WP8S18E11_13050	COG2205	protein histidine kinase activity
WP8S18E11_13060	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E11_13070	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP8S18E11_13100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP8S18E11_13110	COG2867	negative regulation of translational initiation
WP8S18E11_13120	COG2914	Belongs to the UPF0125 (RnfH) family
WP8S18E11_13130	COG1473	amidohydrolase
WP8S18E11_13140	COG1960	acyl-CoA dehydrogenase activity
WP8S18E11_13150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S18E11_13160	COG0121	glutamine amidotransferase
WP8S18E11_13220	COG2197	response regulator
WP8S18E11_13230	COG3850	Histidine kinase
WP8S18E11_13240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP8S18E11_13250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E11_13270	COG0243	molybdopterin cofactor binding
WP8S18E11_13280	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E11_13290	COG0348	domain, Protein
WP8S18E11_13310	COG3005	denitrification pathway
WP8S18E11_13320	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8S18E11_13330	COG0315	cyclic pyranopterin monophosphate synthase activity
WP8S18E11_13340	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP8S18E11_13350	COG0314	molybdopterin synthase activity
WP8S18E11_13380	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP8S18E11_13390	COG2267	carboxylic ester hydrolase activity
WP8S18E11_13400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8S18E11_13420	COG0302	gtp cyclohydrolase
WP8S18E11_13430	COG0840	transmembrane signaling receptor activity
WP8S18E11_13440	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP8S18E11_13460	COG0583	DNA-binding transcription factor activity
WP8S18E11_13470	COG2353	YceI-like domain
WP8S18E11_13490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP8S18E11_13520	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S18E11_13530	COG1166	arginine decarboxylase activity
WP8S18E11_13570	COG0814	amino acid
WP8S18E11_13580	COG0251	oxidation-reduction process
WP8S18E11_13590	COG3681	Belongs to the UPF0597 family
WP8S18E11_13600	COG2964	Protein conserved in bacteria
WP8S18E11_13640	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E11_13650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8S18E11_13660	COG1288	antiporter activity
WP8S18E11_13670	COG0436	Aminotransferase
WP8S18E11_13700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S18E11_13710	COG1196	nuclear chromosome segregation
WP8S18E11_13710	COG0741	lytic transglycosylase activity
WP8S18E11_13710	COG0739	heme binding
WP8S18E11_13740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8S18E11_13760	COG0788	formyltetrahydrofolate deformylase activity
WP8S18E11_13770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S18E11_13810	COG0791	NLP P60 protein
WP8S18E11_13830	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP8S18E11_13850	COG0471	metal ion transport
WP8S18E11_13870	COG1388	LysM domain
WP8S18E11_13870	COG1376	ErfK ybiS ycfS ynhG family protein
WP8S18E11_13880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8S18E11_13890	COG1085	galactose-1-phosphate uridylyltransferase
WP8S18E11_13900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8S18E11_13910	COG1609	Transcriptional regulator
WP8S18E11_13920	COG4580	involved in the transport of maltose and maltodextrins
WP8S18E11_13990	COG2182	Extracellular solute-binding protein
WP8S18E11_14000	COG1175	transmembrane transport
WP8S18E11_14010	COG3833	ABC-type maltose transport systems, permease component
WP8S18E11_14020	COG3867	Arabinogalactan endo-beta-1,4-galactanase
WP8S18E11_14030	COG1874	Beta-galactosidase
WP8S18E11_14040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_14040	COG2190	(PTS) system
WP8S18E11_14040	COG1263	PTS System
WP8S18E11_14050	COG0469	pyruvate kinase activity
WP8S18E11_14100	COG1388	LysM domain
WP8S18E11_14100	COG0741	lytic transglycosylase activity
WP8S18E11_14110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S18E11_14120	COG2226	methyltransferase
WP8S18E11_14130	COG0328	RNA-DNA hybrid ribonuclease activity
WP8S18E11_14140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S18E11_14160	COG0784	Response regulator, receiver
WP8S18E11_14160	COG3437	response regulator, receiver
WP8S18E11_14170	COG2375	cellular response to nickel ion
WP8S18E11_14180	COG4771	TonB-dependent receptor
WP8S18E11_14190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E11_14200	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E11_14210	COG1120	ATPase activity
WP8S18E11_14240	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E11_14250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_14310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_14320	COG1122	ATPase activity
WP8S18E11_14370	COG0708	Exodeoxyribonuclease III
WP8S18E11_14440	COG3132	Protein of unknown function, DUF480
WP8S18E11_14450	COG3300	MHYT domain
WP8S18E11_14450	COG5001	Diguanylate cyclase
WP8S18E11_14470	COG2841	Protein conserved in bacteria
WP8S18E11_14490	COG0534	Mate efflux family protein
WP8S18E11_14540	COG1454	alcohol dehydrogenase
WP8S18E11_14560	COG1309	transcriptional regulator
WP8S18E11_14630	COG3152	Membrane
WP8S18E11_14660	COG0589	response to stress
WP8S18E11_14670	COG0659	secondary active sulfate transmembrane transporter activity
WP8S18E11_14680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_14720	COG3537	Alpha-1,2-mannosidase
WP8S18E11_14740	COG2207	Transcriptional regulator
WP8S18E11_14750	COG0538	isocitrate dehydrogenase activity
WP8S18E11_14770	COG3048	D-serine ammonia-lyase activity
WP8S18E11_14780	COG2610	gluconate transmembrane transporter activity
WP8S18E11_14790	COG0583	DNA-binding transcription factor activity
WP8S18E11_14810	COG0791	NLP P60 protein
WP8S18E11_14820	COG0583	DNA-binding transcription factor activity
WP8S18E11_14830	COG0450	alkyl hydroperoxide reductase
WP8S18E11_14870	COG0500	methyltransferase
WP8S18E11_14880	COG4106	trans-aconitate 2-methyltransferase activity
WP8S18E11_14890	COG1801	Protein of unknown function DUF72
WP8S18E11_14910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP8S18E11_14920	COG0217	transcriptional regulatory protein
WP8S18E11_14930	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E11_14930	COG1454	alcohol dehydrogenase
WP8S18E11_14940	COG2095	MarC family integral membrane protein
WP8S18E11_14960	COG0601	transmembrane transport
WP8S18E11_14970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E11_15010	COG0861	Integral membrane protein TerC family
WP8S18E11_15020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S18E11_15090	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP8S18E11_15100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E11_15110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8S18E11_15130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S18E11_15140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP8S18E11_15150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP8S18E11_15170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP8S18E11_15180	COG0505	Belongs to the CarA family
WP8S18E11_15190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP8S18E11_15250	COG0346	lactoylglutathione lyase activity
WP8S18E11_15260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP8S18E11_15270	COG4660	Part of a membrane complex involved in electron transport
WP8S18E11_15280	COG4659	FMN binding
WP8S18E11_15290	COG4658	electron transport chain
WP8S18E11_15310	COG2878	Part of a membrane complex involved in electron transport
WP8S18E11_15320	COG4657	Part of a membrane complex involved in electron transport
WP8S18E11_15330	COG1061	Type III restriction enzyme res subunit
WP8S18E11_15350	COG0346	lactoylglutathione lyase activity
WP8S18E11_15370	COG1187	pseudouridine synthase activity
WP8S18E11_15380	COG2807	transmembrane transport
WP8S18E11_15400	COG0583	DNA-binding transcription factor activity
WP8S18E11_15430	COG2979	Protein of unknown function (DUF533)
WP8S18E11_15440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8S18E11_15460	COG1294	oxidase, subunit
WP8S18E11_15500	COG3220	belongs to the UPF0276 family
WP8S18E11_15530	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8S18E11_15540	COG2814	Major facilitator Superfamily
WP8S18E11_15550	COG0656	L-ascorbic acid biosynthetic process
WP8S18E11_15590	COG0583	DNA-binding transcription factor activity
WP8S18E11_15600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP8S18E11_15610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8S18E11_15620	COG2271	Major facilitator Superfamily
WP8S18E11_15630	COG2271	Major facilitator Superfamily
WP8S18E11_15640	COG1349	DNA-binding transcription factor activity
WP8S18E11_15660	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S18E11_15670	COG4574	serine-type endopeptidase inhibitor activity
WP8S18E11_15680	COG3085	chromosome segregation
WP8S18E11_15690	COG0583	DNA-binding transcription factor activity
WP8S18E11_15710	COG1448	Aminotransferase
WP8S18E11_15740	COG0658	competence protein
WP8S18E11_15740	COG2333	competence protein COMEC
WP8S18E11_15760	COG1663	tetraacyldisaccharide 4'-kinase activity
WP8S18E11_15770	COG2835	tetraacyldisaccharide 4'-kinase activity
WP8S18E11_15780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP8S18E11_15790	COG2197	response regulator
WP8S18E11_15800	COG0322	excinuclease ABC activity
WP8S18E11_15820	COG3039	Transposase
WP8S18E11_15950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S18E11_15970	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_16000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8S18E11_16020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S18E11_16140	COG2119	membrane
WP8S18E11_16150	COG0023	Translation Initiation Factor
WP8S18E11_16200	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_16220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_16230	COG0765	amino acid transport
WP8S18E11_16240	COG1126	abc transporter atp-binding protein
WP8S18E11_16250	COG0493	'glutamate synthase
WP8S18E11_16260	COG0069	glutamate synthase activity
WP8S18E11_16260	COG0070	glutamate synthase
WP8S18E11_16260	COG0067	glutamate synthase
WP8S18E11_16270	COG1242	4 iron, 4 sulfur cluster binding
WP8S18E11_16360	COG3634	alkyl hydroperoxide reductase activity
WP8S18E11_16380	COG0517	IMP dehydrogenase activity
WP8S18E11_16390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP8S18E11_16400	COG0343	queuine tRNA-ribosyltransferase activity
WP8S18E11_16410	COG1862	Preprotein translocase
WP8S18E11_16420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E11_16430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E11_16440	COG2897	thiosulfate sulfurtransferase activity
WP8S18E11_16460	COG0826	peptidase U32
WP8S18E11_16470	COG0826	peptidase U32
WP8S18E11_16480	COG3154	lipid carrier protein
WP8S18E11_16520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP8S18E11_16530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP8S18E11_16530	COG0574	Belongs to the PEP-utilizing enzyme family
WP8S18E11_16540	COG2207	Transcriptional regulator
WP8S18E11_16580	COG1464	Belongs to the NlpA lipoprotein family
WP8S18E11_16590	COG3083	sulfuric ester hydrolase activity
WP8S18E11_16600	COG3082	Protein of unknown function (DUF1414)
WP8S18E11_16610	COG3081	Nucleoid-associated protein
WP8S18E11_16630	COG1175	transmembrane transport
WP8S18E11_16640	COG3833	ABC-type maltose transport systems, permease component
WP8S18E11_16650	COG3842	ATPase activity
WP8S18E11_16700	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S18E11_16710	COG4783	chaperone-mediated protein folding
WP8S18E11_16730	COG1393	Belongs to the ArsC family
WP8S18E11_16750	COG3385	transposase activity
WP8S18E11_16760	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
WP8S18E11_16770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S18E11_16780	COG2431	L-lysine efflux transmembrane transporter activity
WP8S18E11_16800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_16820	COG4160	amino acid transport
WP8S18E11_16830	COG0564	pseudouridine synthase activity
WP8S18E11_16860	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP8S18E11_16880	COG0625	glutathione transferase activity
WP8S18E11_16900	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8S18E11_16910	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E11_16920	COG0367	asparagine synthase
WP8S18E11_16940	COG4651	solute:proton antiporter activity
WP8S18E11_16940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP8S18E11_16950	COG0647	UMP catabolic process
WP8S18E11_16980	COG1902	pentaerythritol trinitrate reductase activity
WP8S18E11_16990	COG1253	flavin adenine dinucleotide binding
WP8S18E11_17010	COG0247	lactate metabolic process
WP8S18E11_17010	COG0277	FAD linked oxidase domain protein
WP8S18E11_17030	COG2050	protein possibly involved in aromatic compounds catabolism
WP8S18E11_17040	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_17060	COG5001	Diguanylate cyclase
WP8S18E11_17060	COG3300	MHYT domain
WP8S18E11_17070	COG2056	Na+-H+ antiporter family
WP8S18E11_17080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8S18E11_17090	COG0671	phosphoesterase, PA-phosphatase related
WP8S18E11_17100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8S18E11_17110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S18E11_17130	COG0101	tRNA pseudouridine synthase activity
WP8S18E11_17140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP8S18E11_17150	COG0285	dihydrofolate synthase activity
WP8S18E11_17160	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP8S18E11_17170	COG0393	Putative heavy-metal-binding
WP8S18E11_17190	COG1648	precorrin-2 dehydrogenase activity
WP8S18E11_17190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E11_17200	COG4667	esterase of the alpha-beta hydrolase superfamily
WP8S18E11_17210	COG1368	sulfuric ester hydrolase activity
WP8S18E11_17230	COG0527	aspartate kinase activity
WP8S18E11_17240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP8S18E11_17240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S18E11_17250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8S18E11_17290	COG0596	Alpha beta hydrolase
WP8S18E11_17340	COG1136	(ABC) transporter
WP8S18E11_17370	COG2814	Major facilitator Superfamily
WP8S18E11_17420	COG0672	)-iron permease
WP8S18E11_17480	COG0659	secondary active sulfate transmembrane transporter activity
WP8S18E11_17490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP8S18E11_17500	COG0326	Molecular chaperone. Has ATPase activity
WP8S18E11_17510	COG4172	Belongs to the ABC transporter superfamily
WP8S18E11_17520	COG4172	Belongs to the ABC transporter superfamily
WP8S18E11_17540	COG4168	peptide transport system, permease
WP8S18E11_17560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP8S18E11_17570	COG1842	Phage shock protein A
WP8S18E11_17600	COG3106	COG3106 Predicted ATPase
WP8S18E11_17610	COG3768	UPF0283 membrane protein
WP8S18E11_17620	COG0583	DNA-binding transcription factor activity
WP8S18E11_17630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP8S18E11_17640	COG3842	ATPase activity
WP8S18E11_17650	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S18E11_17660	COG1177	transmembrane transport
WP8S18E11_17670	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E11_17690	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP8S18E11_17720	COG2199	diguanylate cyclase activity
WP8S18E11_17730	COG2885	chlorophyll binding
WP8S18E11_17740	COG0861	Integral membrane protein TerC family
WP8S18E11_17770	COG1022	Amp-dependent synthetase and ligase
WP8S18E11_17800	COG2910	NAD(P)H-binding
WP8S18E11_17810	COG0583	DNA-binding transcription factor activity
WP8S18E11_17820	COG0583	DNA-binding transcription factor activity
WP8S18E11_17830	COG0583	DNA-binding transcription factor activity
WP8S18E11_17840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP8S18E11_17860	COG0583	DNA-binding transcription factor activity
WP8S18E11_17870	COG2723	6-phospho-beta-galactosidase activity
WP8S18E11_17880	COG1944	ATP diphosphatase activity
WP8S18E11_17890	COG2116	formate transmembrane transporter activity
WP8S18E11_17900	COG1882	Formate acetyltransferase
WP8S18E11_17910	COG2983	Belongs to the UPF0260 family
WP8S18E11_17930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP8S18E11_17940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP8S18E11_17960	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S18E11_17970	COG1136	(ABC) transporter
WP8S18E11_17980	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8S18E11_17990	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP8S18E11_18010	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP8S18E11_18020	COG0740	serine-type endopeptidase activity
WP8S18E11_18030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP8S18E11_18040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP8S18E11_18050	COG0776	regulation of translation
WP8S18E11_18060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S18E11_18100	COG0488	(ABC) transporter
WP8S18E11_18110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8S18E11_18120	COG3162	membrane
WP8S18E11_18150	COG1024	Enoyl-CoA hydratase
WP8S18E11_18160	COG1115	amino acid carrier protein
WP8S18E11_18210	COG1584	GPR1 FUN34 yaaH family protein
WP8S18E11_18300	COG1024	Enoyl-CoA hydratase
WP8S18E11_18310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP8S18E11_18320	COG1960	acyl-CoA dehydrogenase activity
WP8S18E11_18330	COG1960	acyl-CoA dehydrogenase activity
WP8S18E11_18340	COG1024	Enoyl-CoA hydratase
WP8S18E11_18350	COG1024	Enoyl-CoA hydratase
WP8S18E11_18370	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_18390	COG0730	response to heat
WP8S18E11_18450	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8S18E11_18470	COG2003	Belongs to the UPF0758 family
WP8S18E11_18560	COG2801	Transposase and inactivated derivatives
WP8S18E11_18580	COG0640	Transcriptional regulator
WP8S18E11_18610	COG0798	PFAM Bile acid sodium symporter
WP8S18E11_18620	COG1393	Belongs to the ArsC family
WP8S18E11_18690	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP8S18E11_18710	COG5001	Diguanylate cyclase
WP8S18E11_18710	COG4251	negative regulation of phosphorylation
WP8S18E11_18710	COG3706	GGDEF domain
WP8S18E11_18710	COG2203	Gaf domain
WP8S18E11_18720	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E11_18730	COG3437	response regulator, receiver
WP8S18E11_18760	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
WP8S18E11_18770	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E11_18780	COG5557	Pfam Polysulphide reductase, NrfD
WP8S18E11_18790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
WP8S18E11_18800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP8S18E11_18810	COG1773	rubredoxin
WP8S18E11_18830	COG0601	transmembrane transport
WP8S18E11_18840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E11_18870	COG3842	ATPase activity
WP8S18E11_18890	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
WP8S18E11_18910	COG0375	protein maturation
WP8S18E11_18920	COG0309	Hydrogenase expression formation protein (HypE)
WP8S18E11_18940	COG0298	carbon dioxide binding
WP8S18E11_18950	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
WP8S18E11_18970	COG1921	L-seryl-tRNASec selenium transferase activity
WP8S18E11_18980	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
WP8S18E11_19000	COG3260	NADH ubiquinone oxidoreductase 20
WP8S18E11_19010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_19020	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
WP8S18E11_19020	COG3261	NADH dehydrogenase
WP8S18E11_19030	COG0650	Formate hydrogenlyase subunit 4
WP8S18E11_19040	COG0651	ATP synthesis coupled electron transport
WP8S18E11_19050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E11_19060	COG3158	transport of potassium into the cell
WP8S18E11_19100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E11_19160	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8S18E11_19170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E11_19180	COG3046	protein related to deoxyribodipyrimidine photolyase
WP8S18E11_19190	COG3033	Beta-eliminating lyase
WP8S18E11_19200	COG0295	cytidine deaminase activity
WP8S18E11_19210	COG1346	cytolysis
WP8S18E11_19220	COG1380	Effector of murein hydrolase LrgA
WP8S18E11_19230	COG3345	alpha-galactosidase
WP8S18E11_19250	COG2925	Exonuclease
WP8S18E11_19260	COG0582	viral genome integration into host DNA
WP8S18E11_19530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S18E11_19630	COG4626	Terminase
WP8S18E11_19630	COG1802	Transcriptional regulator
WP8S18E11_19660	COG0616	signal peptide processing
WP8S18E11_19740	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WP8S18E11_19840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP8S18E11_19870	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
WP8S18E11_19950	COG0641	radical SAM
WP8S18E11_20010	COG2304	oxidoreductase activity
WP8S18E11_20040	COG0714	Associated with various cellular activities
WP8S18E11_20050	COG3119	arylsulfatase activity
WP8S18E11_20060	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8S18E11_20070	COG0517	IMP dehydrogenase activity
WP8S18E11_20070	COG0617	tRNA 3'-terminal CCA addition
WP8S18E11_20070	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8S18E11_20080	COG1643	Atp-dependent helicase
WP8S18E11_20100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP8S18E11_20130	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP8S18E11_20140	COG2067	long-chain fatty acid transport protein
WP8S18E11_20150	COG2067	long-chain fatty acid transport protein
WP8S18E11_20170	COG1595	DNA-templated transcription, initiation
WP8S18E11_20190	COG2304	oxidoreductase activity
WP8S18E11_20230	COG0714	Associated with various cellular activities
WP8S18E11_20240	COG0183	Belongs to the thiolase family
WP8S18E11_20250	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S18E11_20250	COG1024	Enoyl-CoA hydratase
WP8S18E11_20260	COG2719	SpoVR family
WP8S18E11_20270	COG2718	Belongs to the UPF0229 family
WP8S18E11_20280	COG2766	serine protein kinase
WP8S18E11_20290	COG0514	ATP-dependent DNA helicase (RecQ)
WP8S18E11_20300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP8S18E11_20320	COG0814	amino acid
WP8S18E11_20330	COG0494	nUDIX hydrolase
WP8S18E11_20360	COG2824	Alkylphosphonate utilization operon protein PhnA
WP8S18E11_20400	COG0406	alpha-ribazole phosphatase activity
WP8S18E11_20410	COG3706	GGDEF domain
WP8S18E11_20420	COG2840	Smr protein MutS2
WP8S18E11_20430	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S18E11_20440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP8S18E11_20460	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_20470	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP8S18E11_20480	COG0814	amino acid
WP8S18E11_20490	COG1609	Transcriptional regulator
WP8S18E11_20500	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_20500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_20510	COG1105	Belongs to the carbohydrate kinase PfkB family
WP8S18E11_20520	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP8S18E11_20520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_20520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8S18E11_20530	COG3313	Fe-S protein
WP8S18E11_20540	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP8S18E11_20550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8S18E11_20560	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S18E11_20570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8S18E11_20590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E11_20610	COG3385	transposase activity
WP8S18E11_20620	COG0366	Alpha amylase catalytic
WP8S18E11_20660	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP8S18E11_20670	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP8S18E11_20680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP8S18E11_20690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP8S18E11_20700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP8S18E11_20710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E11_20710	COG0072	phenylalanine-tRNA ligase activity
WP8S18E11_20720	COG0776	regulation of translation
WP8S18E11_20730	COG0784	Response regulator, receiver
WP8S18E11_20730	COG2205	protein histidine kinase activity
WP8S18E11_20770	COG1609	Transcriptional regulator
WP8S18E11_20780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_20790	COG1879	ABC-type sugar transport system periplasmic component
WP8S18E11_20800	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8S18E11_20810	COG1129	ABC transporter
WP8S18E11_20820	COG1869	D-ribose catabolic process
WP8S18E11_20830	COG0625	glutathione transferase activity
WP8S18E11_20850	COG1177	transmembrane transport
WP8S18E11_20860	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8S18E11_20880	COG3423	Transcriptional regulator
WP8S18E11_20890	COG2801	Transposase and inactivated derivatives
WP8S18E11_20900	COG2842	Transposition protein
WP8S18E11_21110	COG0640	Transcriptional regulator
WP8S18E11_21150	COG4373	Mu-like prophage FluMu protein gp28
WP8S18E11_21160	COG4383	Mu-like prophage protein gp29
WP8S18E11_21190	COG4397	Mu-like prophage major head subunit gpT
WP8S18E11_21270	COG4386	tail sheath protein
WP8S18E11_21290	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
WP8S18E11_21330	COG4384	Bacteriophage Mu Gp45 protein
WP8S18E11_21350	COG3299	homolog of phage Mu protein gp47
WP8S18E11_21410	COG3385	transposase activity
WP8S18E11_21420	COG0037	tRNA processing
WP8S18E11_21430	COG0589	response to stress
WP8S18E11_21440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S18E11_21470	COG2217	Heavy metal translocating P-type atpase
WP8S18E11_21490	COG2010	Cytochrome c
WP8S18E11_21520	COG3278	Belongs to the heme-copper respiratory oxidase family
WP8S18E11_21540	COG1956	GAF domain-containing protein
WP8S18E11_21550	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP8S18E11_21570	COG0308	aminopeptidase N
WP8S18E11_21590	COG2902	Dehydrogenase
WP8S18E11_21600	COG0167	dihydroorotate dehydrogenase activity
WP8S18E11_21620	COG0254	rRNA binding
WP8S18E11_21630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP8S18E11_21640	COG0116	Belongs to the methyltransferase superfamily
WP8S18E11_21640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S18E11_21680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8S18E11_21690	COG1067	ATP-dependent peptidase activity
WP8S18E11_21780	COG4128	Pfam Zonular occludens toxin
WP8S18E11_21830	COG3141	response to X-ray
WP8S18E11_21840	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8S18E11_21850	COG4221	oxidoreductase activity
WP8S18E11_21940	COG0372	Belongs to the citrate synthase family
WP8S18E11_21950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP8S18E11_21970	COG2995	paraquat-inducible protein a
WP8S18E11_21980	COG3008	intermembrane lipid transfer
WP8S18E11_21990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E11_21990	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP8S18E11_22020	COG0084	hydrolase, TatD family'
WP8S18E11_22030	COG0470	DNA polymerase III
WP8S18E11_22040	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP8S18E11_22050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP8S18E11_22060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP8S18E11_22080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP8S18E11_22090	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_22110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP8S18E11_22120	COG0416	fatty acid biosynthetic process
WP8S18E11_22130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP8S18E11_22150	COG0424	maF-like protein
WP8S18E11_22160	COG0583	DNA-binding transcription factor activity
WP8S18E11_22200	COG0546	phosphoglycolate phosphatase activity
WP8S18E11_22210	COG0564	pseudouridine synthase activity
WP8S18E11_22220	COG1530	ribonuclease E activity
WP8S18E11_22230	COG3385	transposase activity
WP8S18E11_22270	COG0306	phosphate transporter
WP8S18E11_22280	COG0717	Belongs to the dCTP deaminase family
WP8S18E11_22290	COG0572	uridine kinase
WP8S18E11_22300	COG0489	protein tyrosine kinase activity
WP8S18E11_22310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E11_22310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8S18E11_22330	COG1254	Belongs to the acylphosphatase family
WP8S18E11_22340	COG0840	transmembrane signaling receptor activity
WP8S18E11_22350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8S18E11_22380	COG0709	Synthesizes selenophosphate from selenide and ATP
WP8S18E11_22390	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP8S18E11_22400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8S18E11_22420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP8S18E11_22430	COG3039	Transposase
WP8S18E11_22450	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E11_22460	COG2267	carboxylic ester hydrolase activity
WP8S18E11_22480	COG1214	PFAM Peptidase M22, glycoprotease
WP8S18E11_22490	COG1199	ATP-dependent helicase activity
WP8S18E11_22510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP8S18E11_22520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP8S18E11_22530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP8S18E11_22540	COG0131	Imidazoleglycerol-phosphate dehydratase
WP8S18E11_22540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S18E11_22560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP8S18E11_22570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP8S18E11_22580	COG3437	response regulator, receiver
WP8S18E11_22600	COG2205	protein histidine kinase activity
WP8S18E11_22600	COG0784	Response regulator, receiver
WP8S18E11_22600	COG2198	Histidine kinase
WP8S18E11_22610	COG0107	imidazoleglycerol-phosphate synthase activity
WP8S18E11_22650	COG3706	GGDEF domain
WP8S18E11_22660	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E11_22670	COG1288	antiporter activity
WP8S18E11_22690	COG3134	Outer membrane lipoprotein
WP8S18E11_22700	COG2080	2 iron, 2 sulfur cluster binding
WP8S18E11_22710	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP8S18E11_22720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP8S18E11_22730	COG2252	PERMEase
WP8S18E11_22740	COG0402	S-adenosylhomocysteine deaminase activity
WP8S18E11_22750	COG2233	PERMEase
WP8S18E11_22760	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP8S18E11_22760	COG2080	2 iron, 2 sulfur cluster binding
WP8S18E11_22770	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP8S18E11_22780	COG0402	S-adenosylhomocysteine deaminase activity
WP8S18E11_22790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E11_22790	COG0493	'glutamate synthase
WP8S18E11_22800	COG2068	MobA-Related Protein
WP8S18E11_22810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP8S18E11_22820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WP8S18E11_22820	COG3608	succinylglutamate desuccinylase aspartoacylase
WP8S18E11_22840	COG0697	spore germination
WP8S18E11_22860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E11_22890	COG0549	Belongs to the carbamate kinase family
WP8S18E11_22910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8S18E11_22920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP8S18E11_22930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8S18E11_22970	COG3039	Transposase
WP8S18E11_22990	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S18E11_23000	COG0641	radical SAM
WP8S18E11_23050	COG0242	peptide deformylase activity
WP8S18E11_23090	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8S18E11_23100	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP8S18E11_23120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8S18E11_23130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP8S18E11_23150	COG0205	6-phosphofructokinase activity
WP8S18E11_23180	COG3039	Transposase
WP8S18E11_23190	COG3123	guanosine phosphorylase activity
WP8S18E11_23200	COG1760	l-serine dehydratase
WP8S18E11_23210	COG1760	l-serine dehydratase
WP8S18E11_23220	COG3100	YcgL domain-containing protein
WP8S18E11_23230	COG0850	regulation of cytokinetic process
WP8S18E11_23240	COG2894	cell division
WP8S18E11_23250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP8S18E11_23260	COG3099	Belongs to the UPF0263 family
WP8S18E11_23270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8S18E11_23350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP8S18E11_23360	COG0697	spore germination
WP8S18E11_23370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP8S18E11_23380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E11_23420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_23430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E11_23440	COG0307	riboflavin synthase, alpha
WP8S18E11_23490	COG4681	YaeQ
WP8S18E11_23520	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8S18E11_23530	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP8S18E11_23540	COG0586	Pfam SNARE associated Golgi protein
WP8S18E11_23560	COG0556	nucleotide-excision repair
WP8S18E11_23570	COG2985	domain, Protein
WP8S18E11_23570	COG0569	domain protein
WP8S18E11_23580	COG3385	transposase activity
WP8S18E11_23600	COG3385	transposase activity
WP8S18E11_23610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8S18E11_23620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP8S18E11_23620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E11_23650	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E11_23680	COG1451	nucleotide metabolic process
WP8S18E11_23710	COG0417	DNA replication proofreading
WP8S18E11_23730	COG2203	Gaf domain
WP8S18E11_23730	COG2199	diguanylate cyclase activity
WP8S18E11_23760	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E11_23770	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E11_23800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP8S18E11_23830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP8S18E11_23840	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WP8S18E11_23850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP8S18E11_23860	COG2832	Protein of unknown function (DUF454)
WP8S18E11_23870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E11_23900	COG1011	Hydrolase
WP8S18E11_23910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S18E11_23940	COG3593	DNA synthesis involved in DNA repair
WP8S18E11_23970	COG0583	DNA-binding transcription factor activity
WP8S18E11_23980	COG0730	response to heat
WP8S18E11_24000	COG1940	carbohydrate kinase activity
WP8S18E11_24000	COG1846	Transcriptional regulator
WP8S18E11_24010	COG0840	transmembrane signaling receptor activity
WP8S18E11_24020	COG3012	SEC-C Motif Domain Protein
WP8S18E11_24030	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP8S18E11_24040	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP8S18E11_24050	COG0247	lactate metabolic process
WP8S18E11_24080	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP8S18E11_24090	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E11_24100	COG3301	Polysulphide reductase, NrfD
WP8S18E11_24110	COG1138	Cytochrome C-type biogenesis protein
WP8S18E11_24130	COG3088	subunit of a heme lyase
WP8S18E11_24130	COG4235	cytochrome complex assembly
WP8S18E11_24190	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S18E11_24200	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S18E11_24210	COG0567	Dehydrogenase, E1 component
WP8S18E11_24230	COG1053	succinate dehydrogenase
WP8S18E11_24240	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP8S18E11_24300	COG1742	UPF0060 membrane protein
WP8S18E11_24330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8S18E11_24370	COG2501	S4 domain
WP8S18E11_24390	COG1132	(ABC) transporter
WP8S18E11_24400	COG1132	(ABC) transporter
WP8S18E11_24420	COG3118	belongs to the thioredoxin family
WP8S18E11_24430	COG0471	metal ion transport
WP8S18E11_24440	COG0058	SHG alpha-glucan phosphorylase activity
WP8S18E11_24470	COG0697	spore germination
WP8S18E11_24510	COG2062	phosphohistidine phosphatase, SixA
WP8S18E11_24520	COG1025	Belongs to the peptidase M16 family
WP8S18E11_24560	COG3039	Transposase
WP8S18E11_24580	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S18E11_24580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S18E11_24590	COG0516	GMP reductase activity
WP8S18E11_24590	COG0517	IMP dehydrogenase activity
WP8S18E11_24600	COG1278	Cold shock
WP8S18E11_24610	COG1570	exodeoxyribonuclease VII activity
WP8S18E11_24620	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP8S18E11_24640	COG0386	Belongs to the glutathione peroxidase family
WP8S18E11_24650	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_24670	COG0840	transmembrane signaling receptor activity
WP8S18E11_24680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E11_24690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP8S18E11_24700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP8S18E11_24800	COG5001	Diguanylate cyclase
WP8S18E11_24800	COG3300	MHYT domain
WP8S18E11_24830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_24850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP8S18E11_24860	COG0563	adenylate kinase activity
WP8S18E11_24880	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP8S18E11_24890	COG1286	toxin biosynthetic process
WP8S18E11_24900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP8S18E11_24910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP8S18E11_24920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP8S18E11_24930	COG0531	amino acid
WP8S18E11_24930	COG1674	ftsk spoiiie
WP8S18E11_24950	COG0686	Belongs to the AlaDH PNT family
WP8S18E11_24960	COG0492	ferredoxin-NADP+ reductase activity
WP8S18E11_24970	COG3706	GGDEF domain
WP8S18E11_24980	COG3134	Outer membrane lipoprotein
WP8S18E11_24990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP8S18E11_25000	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP8S18E11_25010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP8S18E11_25020	COG0542	response to heat
WP8S18E11_25030	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP8S18E11_25040	COG1278	Cold shock
WP8S18E11_25050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP8S18E11_25060	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_25070	COG2205	protein histidine kinase activity
WP8S18E11_25090	COG0392	lysyltransferase activity
WP8S18E11_25090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP8S18E11_25170	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_25210	COG1435	thymidine kinase activity
WP8S18E11_25220	COG1757	Na H antiporter
WP8S18E11_25230	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8S18E11_25240	COG2096	Adenosyltransferase
WP8S18E11_25250	COG3530	Putative quorum-sensing-regulated virulence factor
WP8S18E11_25260	COG0602	queuosine metabolic process
WP8S18E11_25270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP8S18E11_25310	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP8S18E11_25330	COG0776	regulation of translation
WP8S18E11_25340	COG0539	negative regulation of cytoplasmic translation
WP8S18E11_25350	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP8S18E11_25360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8S18E11_25390	COG2814	Major facilitator Superfamily
WP8S18E11_25430	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP8S18E11_25440	COG5001	Diguanylate cyclase
WP8S18E11_25440	COG3300	MHYT domain
WP8S18E11_25450	COG0583	DNA-binding transcription factor activity
WP8S18E11_25460	COG3437	response regulator, receiver
WP8S18E11_25510	COG4989	oxidoreductase activity
WP8S18E11_25520	COG0724	RNA recognition motif
WP8S18E11_25540	COG1126	abc transporter atp-binding protein
WP8S18E11_25550	COG0765	amino acid transport
WP8S18E11_25560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_25570	COG0765	amino acid transport
WP8S18E11_25580	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
WP8S18E11_25600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP8S18E11_25640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP8S18E11_25660	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E11_25670	COG1360	Flagellar Motor Protein
WP8S18E11_25680	COG4771	TonB-dependent receptor
WP8S18E11_25690	COG1770	oligopeptidase
WP8S18E11_25730	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_25740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_25750	COG0649	NAD binding
WP8S18E11_25750	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_25780	COG1034	ATP synthesis coupled electron transport
WP8S18E11_25790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP8S18E11_25800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_25810	COG0839	Belongs to the complex I subunit 6 family
WP8S18E11_25820	COG0713	ATP synthesis coupled electron transport
WP8S18E11_25840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8S18E11_25850	COG1007	ATP synthesis coupled electron transport
WP8S18E11_25860	COG0047	phosphoribosylformylglycinamidine synthase activity
WP8S18E11_25860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP8S18E11_25870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8S18E11_25890	COG1645	bacterial-type flagellum-dependent swarming motility
WP8S18E11_25900	COG1160	GTP binding
WP8S18E11_25910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E11_25920	COG2976	Protein conserved in bacteria
WP8S18E11_25930	COG0124	histidyl-tRNA synthetase
WP8S18E11_25950	COG1426	Protein conserved in bacteria
WP8S18E11_25970	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP8S18E11_25980	COG0105	UTP biosynthetic process
WP8S18E11_26010	COG0633	Ferredoxin
WP8S18E11_26020	COG0443	Heat shock 70 kDa protein
WP8S18E11_26030	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8S18E11_26050	COG0822	iron-sulfur transferase activity
WP8S18E11_26060	COG1104	cysteine desulfurase activity
WP8S18E11_26070	COG1959	2 iron, 2 sulfur cluster binding
WP8S18E11_26140	COG3039	Transposase
WP8S18E11_26240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S18E11_26240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8S18E11_26250	COG0509	glycine decarboxylation via glycine cleavage system
WP8S18E11_26260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP8S18E11_26270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E11_26280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8S18E11_26310	COG2814	Major facilitator Superfamily
WP8S18E11_26320	COG0625	glutathione transferase activity
WP8S18E11_26340	COG0483	inositol monophosphate 1-phosphatase activity
WP8S18E11_26370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP8S18E11_26400	COG1086	Polysaccharide biosynthesis protein
WP8S18E11_26410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP8S18E11_26440	COG3848	Pyruvate phosphate dikinase
WP8S18E11_26440	COG0574	Belongs to the PEP-utilizing enzyme family
WP8S18E11_26470	COG3039	Transposase
WP8S18E11_26480	COG0529	Catalyzes the synthesis of activated sulfate
WP8S18E11_26530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP8S18E11_26550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP8S18E11_26590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP8S18E11_26630	COG1442	glycosyl transferase family 8
WP8S18E11_26640	COG1215	transferase activity, transferring glycosyl groups
WP8S18E11_26670	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E11_26680	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_26710	COG1083	cytidylyl-transferase
WP8S18E11_26730	COG2089	acid synthase
WP8S18E11_26780	COG4310	Domain of unknown function (DUF2172)
WP8S18E11_26890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8S18E11_26920	COG0301	tRNA thio-modification
WP8S18E11_26920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E11_26950	COG4953	penicillin-binding protein 1C
WP8S18E11_26960	COG2373	Large extracellular alpha-helical protein
WP8S18E11_26980	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E11_26990	COG5001	Diguanylate cyclase
WP8S18E11_26990	COG3300	MHYT domain
WP8S18E11_27000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S18E11_27020	COG1252	NADH dehydrogenase
WP8S18E11_27030	COG3150	esterase
WP8S18E11_27040	COG2233	PERMEase
WP8S18E11_27060	COG2354	Protein conserved in bacteria
WP8S18E11_27090	COG1301	dicarboxylic acid transport
WP8S18E11_27110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP8S18E11_27140	COG0537	adenosine 5'-monophosphoramidase activity
WP8S18E11_27210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E11_27220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8S18E11_27240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8S18E11_27250	COG1605	Chorismate mutase
WP8S18E11_27250	COG0287	Prephenate dehydrogenase
WP8S18E11_27270	COG1199	ATP-dependent helicase activity
WP8S18E11_27290	COG3385	transposase activity
WP8S18E11_27300	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP8S18E11_27310	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP8S18E11_27320	COG1785	Belongs to the alkaline phosphatase family
WP8S18E11_27360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8S18E11_27370	COG2197	response regulator
WP8S18E11_27400	COG3706	GGDEF domain
WP8S18E11_27410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_27420	COG0765	amino acid transport
WP8S18E11_27450	COG1126	abc transporter atp-binding protein
WP8S18E11_27480	COG0531	amino acid
WP8S18E11_27510	COG1253	flavin adenine dinucleotide binding
WP8S18E11_27520	COG0704	Plays a role in the regulation of phosphate uptake
WP8S18E11_27540	COG0581	inorganic phosphate transmembrane transporter activity
WP8S18E11_27550	COG0573	inorganic phosphate transmembrane transporter activity
WP8S18E11_27560	COG0590	tRNA wobble adenosine to inosine editing
WP8S18E11_27590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP8S18E11_27630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP8S18E11_27640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP8S18E11_27650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP8S18E11_27660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP8S18E11_27680	COG3852	Histidine kinase
WP8S18E11_27710	COG2716	regulation of RNA biosynthetic process
WP8S18E11_27720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP8S18E11_27740	COG2239	Acts as a magnesium transporter
WP8S18E11_27780	COG1706	bacterial-type flagellum-dependent cell motility
WP8S18E11_27790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP8S18E11_27810	COG4787	bacterial-type flagellum-dependent cell motility
WP8S18E11_27820	COG3385	transposase activity
WP8S18E11_27830	COG1749	Flagellar hook protein flgE
WP8S18E11_27840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WP8S18E11_27860	COG1815	bacterial-type flagellum-dependent cell motility
WP8S18E11_27870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP8S18E11_27880	COG0835	chemotaxis
WP8S18E11_27880	COG0784	Response regulator, receiver
WP8S18E11_27890	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP8S18E11_27920	COG0622	Phosphoesterase
WP8S18E11_27930	COG4166	transmembrane transport
WP8S18E11_27950	COG1187	pseudouridine synthase activity
WP8S18E11_27980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8S18E11_27990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8S18E11_28000	COG1882	Formate acetyltransferase
WP8S18E11_28010	COG1349	DNA-binding transcription factor activity
WP8S18E11_28020	COG0697	spore germination
WP8S18E11_28030	COG0747	negative chemotaxis
WP8S18E11_28060	COG0583	DNA-binding transcription factor activity
WP8S18E11_28090	COG1121	(ABC) transporter
WP8S18E11_28160	COG4771	TonB-dependent receptor
WP8S18E11_28200	COG1278	Cold shock
WP8S18E11_28250	COG4771	TonB-dependent receptor
WP8S18E11_28270	COG0741	lytic transglycosylase activity
WP8S18E11_28290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP8S18E11_28310	COG2911	Protein conserved in bacteria
WP8S18E11_28320	COG0729	surface antigen
WP8S18E11_28340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8S18E11_28350	COG3039	Transposase
WP8S18E11_28410	COG2003	Belongs to the UPF0758 family
WP8S18E11_28550	COG1660	Displays ATPase and GTPase activities
WP8S18E11_28590	COG3173	Aminoglycoside phosphotransferase
WP8S18E11_28720	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8S18E11_28740	COG4134	Bacterial extracellular solute-binding protein
WP8S18E11_28760	COG4136	ATPase activity
WP8S18E11_28770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP8S18E11_28780	COG2951	lytic endotransglycosylase activity
WP8S18E11_28790	COG0033	Phosphoglucomutase
WP8S18E11_28800	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP8S18E11_28810	COG0596	Alpha beta hydrolase
WP8S18E11_28840	COG0716	FMN binding
WP8S18E11_28860	COG0735	belongs to the Fur family
WP8S18E11_28870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E11_28890	COG2190	(PTS) system
WP8S18E11_28890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_28890	COG1263	PTS System
WP8S18E11_28900	COG0363	glucosamine-6-phosphate deaminase activity
WP8S18E11_28910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S18E11_28920	COG1846	Transcriptional regulator
WP8S18E11_28920	COG1940	carbohydrate kinase activity
WP8S18E11_28930	COG2194	sulfuric ester hydrolase activity
WP8S18E11_28960	COG3275	phosphorelay sensor kinase activity
WP8S18E11_28970	COG3279	Response regulator of the LytR AlgR family
WP8S18E11_28980	COG1966	Carbon starvation protein
WP8S18E11_29000	COG1566	PFAM secretion protein HlyD family protein
WP8S18E11_29010	COG1061	Type III restriction enzyme res subunit
WP8S18E11_29020	COG2027	D-alanyl-D-alanine carboxypeptidase
WP8S18E11_29030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP8S18E11_29040	COG3021	interspecies interaction between organisms
WP8S18E11_29060	COG1607	acyl-coa hydrolase
WP8S18E11_29070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8S18E11_29090	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP8S18E11_29090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP8S18E11_29090	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP8S18E11_29090	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP8S18E11_29120	COG0633	Ferredoxin
WP8S18E11_29120	COG3217	Mosc domain protein beta barrel domain protein
WP8S18E11_29120	COG3217	Mosc domain protein beta barrel domain protein
WP8S18E11_29120	COG0633	Ferredoxin
WP8S18E11_29140	COG0501	Belongs to the peptidase M48B family
WP8S18E11_29150	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP8S18E11_29160	COG1073	alpha beta
WP8S18E11_29160	COG2226	methyltransferase
WP8S18E11_29170	COG0156	8-amino-7-oxononanoate synthase activity
WP8S18E11_29180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8S18E11_29190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WP8S18E11_29220	COG0017	Asparaginyl-tRNA synthetase
WP8S18E11_29240	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8S18E11_29260	COG1473	amidohydrolase
WP8S18E11_29270	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E11_29290	COG1393	Belongs to the ArsC family
WP8S18E11_29300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8S18E11_29310	COG1876	peptidase activity
WP8S18E11_29440	COG3039	Transposase
WP8S18E11_29450	COG2932	Transcriptional regulator
WP8S18E11_29460	COG3263	regulation of cellular component size
WP8S18E11_29490	COG1280	lysine exporter protein (LysE YggA)
WP8S18E11_29540	COG1957	nucleoside hydrolase
WP8S18E11_29570	COG1454	alcohol dehydrogenase
WP8S18E11_29710	COG4397	Mu-like prophage major head subunit gpT
WP8S18E11_29720	COG4388	Caudovirus prohead serine protease
WP8S18E11_29760	COG4383	Mu-like prophage protein gp29
WP8S18E11_29770	COG4373	Mu-like prophage FluMu protein gp28
WP8S18E11_29790	COG0640	Transcriptional regulator
WP8S18E11_30020	COG1454	alcohol dehydrogenase
WP8S18E11_30030	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E11_30040	COG0702	epimerase
WP8S18E11_30060	COG0095	Lipoate-protein ligase
WP8S18E11_30080	COG0577	efflux transmembrane transporter activity
WP8S18E11_30080	COG1136	(ABC) transporter
WP8S18E11_30090	COG0577	efflux transmembrane transporter activity
WP8S18E11_30090	COG1136	(ABC) transporter
WP8S18E11_30100	COG0577	efflux transmembrane transporter activity
WP8S18E11_30100	COG1136	(ABC) transporter
WP8S18E11_30110	COG1566	PFAM secretion protein HlyD family protein
WP8S18E11_30180	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E11_30200	COG1285	pathogenesis
WP8S18E11_30260	COG0484	heat shock protein binding
WP8S18E11_30270	COG0443	Heat shock 70 kDa protein
WP8S18E11_30280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP8S18E11_30290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP8S18E11_30300	COG0497	DNA recombination
WP8S18E11_30310	COG1227	inorganic diphosphatase activity
WP8S18E11_30320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_30330	COG1136	(ABC) transporter
WP8S18E11_30330	COG0577	efflux transmembrane transporter activity
WP8S18E11_30370	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WP8S18E11_30390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8S18E11_30400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8S18E11_30420	COG3385	transposase activity
WP8S18E11_30430	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP8S18E11_30460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP8S18E11_30490	COG0297	glycogen (starch) synthase activity
WP8S18E11_30500	COG3306	glycosyltransferase involved in LPS biosynthesis
WP8S18E11_30570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8S18E11_30590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8S18E11_30600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8S18E11_30610	COG1309	transcriptional regulator
WP8S18E11_30640	COG1342	Belongs to the UPF0251 family
WP8S18E11_30700	COG0625	glutathione transferase activity
WP8S18E11_30710	COG0259	pyridoxamine-phosphate oxidase activity
WP8S18E11_30740	COG3385	transposase activity
WP8S18E11_30760	COG3385	transposase activity
WP8S18E11_30800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E11_30800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E11_30810	COG0251	oxidation-reduction process
WP8S18E11_30820	COG1882	Formate acetyltransferase
WP8S18E11_30830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8S18E11_30850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP8S18E11_30860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP8S18E11_30900	COG3088	subunit of a heme lyase
WP8S18E11_30900	COG4235	cytochrome complex assembly
WP8S18E11_30910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S18E11_30920	COG1138	Cytochrome C-type biogenesis protein
WP8S18E11_30930	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP8S18E11_30940	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E11_30950	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E11_30960	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8S18E11_30990	COG0835	chemotaxis
WP8S18E11_31010	COG1192	Involved in chromosome partitioning
WP8S18E11_31020	COG1360	Flagellar Motor Protein
WP8S18E11_31030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E11_31040	COG2201	protein-glutamate methylesterase activity
WP8S18E11_31050	COG0643	Histidine kinase
WP8S18E11_31050	COG2198	Histidine kinase
WP8S18E11_31050	COG0784	Response regulator, receiver
WP8S18E11_31060	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP8S18E11_31110	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP8S18E11_31130	COG1684	flagellar biosynthetic protein fliR
WP8S18E11_31240	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP8S18E11_31260	COG1677	Flagellar hook-basal body complex protein FliE
WP8S18E11_31290	COG0469	pyruvate kinase activity
WP8S18E11_31300	COG1737	Transcriptional regulator
WP8S18E11_31310	COG0837	glucose binding
WP8S18E11_31370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_31390	COG0281	malic enzyme
WP8S18E11_31430	COG0437	4 iron, 4 sulfur cluster binding
WP8S18E11_31440	COG3383	formate dehydrogenase (NAD+) activity
WP8S18E11_31440	COG3383	formate dehydrogenase (NAD+) activity
WP8S18E11_31500	COG3039	Transposase
WP8S18E11_31530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP8S18E11_31550	COG3852	Histidine kinase
WP8S18E11_31560	COG2204	response regulator
WP8S18E11_31580	COG4662	Binding-protein-dependent transport system inner membrane component
WP8S18E11_31600	COG0746	molybdenum cofactor guanylyltransferase activity
WP8S18E11_31610	COG0303	'Molybdopterin
WP8S18E11_31620	COG1289	transmembrane transporter activity
WP8S18E11_31680	COG2205	protein histidine kinase activity
WP8S18E11_31680	COG0784	Response regulator, receiver
WP8S18E11_31710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8S18E11_31720	COG0444	Belongs to the ABC transporter superfamily
WP8S18E11_31730	COG4608	Belongs to the ABC transporter superfamily
WP8S18E11_31750	COG2971	BadF BadG BcrA BcrD
WP8S18E11_31800	COG3724	N-succinylarginine dihydrolase activity
WP8S18E11_31840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8S18E11_31860	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S18E11_31870	COG3706	GGDEF domain
WP8S18E11_31880	COG2211	Major facilitator Superfamily
WP8S18E11_31890	COG0616	signal peptide processing
WP8S18E11_31900	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_31910	COG0583	DNA-binding transcription factor activity
WP8S18E11_31930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8S18E11_31970	COG1881	PFAM PEBP family protein
WP8S18E11_32000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP8S18E11_32040	COG1301	dicarboxylic acid transport
WP8S18E11_32050	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP8S18E11_32060	COG2912	Transglutaminase-like superfamily
WP8S18E11_32080	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8S18E11_32090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP8S18E11_32100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP8S18E11_32110	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP8S18E11_32120	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP8S18E11_32130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP8S18E11_32140	COG0737	Belongs to the 5'-nucleotidase family
WP8S18E11_32150	COG0193	aminoacyl-tRNA hydrolase activity
WP8S18E11_32160	COG0012	GTP binding
WP8S18E11_32170	COG0490	domain, Protein
WP8S18E11_32170	COG0471	metal ion transport
WP8S18E11_32190	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
WP8S18E11_32230	COG0366	Alpha amylase catalytic
WP8S18E11_32250	COG0488	(ABC) transporter
WP8S18E11_32270	COG3385	transposase activity
WP8S18E11_32290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E11_32320	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E11_32330	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E11_32350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP8S18E11_32360	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8S18E11_32380	COG0180	Tryptophanyl-tRNA synthetase
WP8S18E11_32400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP8S18E11_32410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP8S18E11_32430	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP8S18E11_32440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP8S18E11_32500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP8S18E11_32520	COG0583	DNA-binding transcription factor activity
WP8S18E11_32560	COG0583	DNA-binding transcription factor activity
WP8S18E11_32580	COG0739	heme binding
WP8S18E11_32600	COG1511	domain protein
WP8S18E11_32600	COG3264	Mechanosensitive ion channel
WP8S18E11_32610	COG0584	glycerophosphoryl diester phosphodiesterase
WP8S18E11_32630	COG1053	succinate dehydrogenase
WP8S18E11_32640	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP8S18E11_32650	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S18E11_32660	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8S18E11_32670	COG3385	transposase activity
WP8S18E11_32680	COG3385	transposase activity
WP8S18E11_32690	COG0602	queuosine metabolic process
WP8S18E11_32730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP8S18E11_32740	COG3115	cell septum assembly
WP8S18E11_32750	COG1196	nuclear chromosome segregation
WP8S18E11_32770	COG2860	membrane
WP8S18E11_32790	COG3108	Peptidase M15
WP8S18E11_32800	COG2989	Protein conserved in bacteria
WP8S18E11_32830	COG0463	Glycosyl transferase, family 2
WP8S18E11_32860	COG0366	Alpha amylase catalytic
WP8S18E11_32930	COG2199	diguanylate cyclase activity
WP8S18E11_32930	COG2203	Gaf domain
WP8S18E11_32950	COG3590	peptidase
WP8S18E11_32980	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8S18E11_32990	COG1982	Orn Lys Arg decarboxylase major
WP8S18E11_33000	COG0531	amino acid
WP8S18E11_33020	COG3710	Transcriptional regulator
WP8S18E11_33030	COG0531	amino acid
WP8S18E11_33040	COG0814	amino acid
WP8S18E11_33070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S18E11_33080	COG0739	heme binding
WP8S18E11_33090	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP8S18E11_33110	COG0251	oxidation-reduction process
WP8S18E11_33130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP8S18E11_33150	COG3091	SprT-like family
WP8S18E11_33170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP8S18E11_33180	COG0189	ligase activity
WP8S18E11_33190	COG3385	transposase activity
WP8S18E11_33220	COG1022	Amp-dependent synthetase and ligase
WP8S18E11_33240	COG4221	oxidoreductase activity
WP8S18E11_33270	COG0642	Histidine kinase
WP8S18E11_33290	COG0516	GMP reductase activity
WP8S18E11_33310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP8S18E11_33320	COG3647	Membrane
WP8S18E11_33340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8S18E11_33410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E11_33420	COG0473	3-isopropylmalate dehydrogenase activity
WP8S18E11_33440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP8S18E11_33450	COG2363	Small membrane protein
WP8S18E11_33470	COG0583	DNA-binding transcription factor activity
WP8S18E11_33480	COG0840	transmembrane signaling receptor activity
WP8S18E11_33490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8S18E11_33520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP8S18E11_33530	COG1666	GTP binding
WP8S18E11_33550	COG2211	Major facilitator Superfamily
WP8S18E11_33560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8S18E11_33580	COG2813	Specifically methylates the guanine in position
WP8S18E11_33590	COG0271	Belongs to the BolA IbaG family
WP8S18E11_33600	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E11_33610	COG1805	sodium ion transport
WP8S18E11_33620	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E11_33630	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E11_33640	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8S18E11_33650	COG2871	sodium ion transport
WP8S18E11_33660	COG1477	protein flavinylation
WP8S18E11_33720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP8S18E11_33750	COG0300	oxidoreductase activity
WP8S18E11_33770	COG0415	Belongs to the DNA photolyase family
WP8S18E11_33780	COG0789	Transcriptional regulator
WP8S18E11_33790	COG3272	Protein of unknown function (DUF1722)
WP8S18E11_33850	COG0077	Prephenate dehydratase
WP8S18E11_33850	COG1605	Chorismate mutase
WP8S18E11_33900	COG2801	Transposase and inactivated derivatives
WP8S18E11_33980	COG1160	GTP binding
WP8S18E11_34040	COG2801	Transposase and inactivated derivatives
WP8S18E11_34080	COG0300	oxidoreductase activity
WP8S18E11_34130	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP8S18E11_34210	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP8S18E11_34220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_34240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_34250	COG0826	peptidase U32
WP8S18E11_34260	COG1280	lysine exporter protein (LysE YggA)
WP8S18E11_34320	COG2198	Histidine kinase
WP8S18E11_34320	COG0643	Histidine kinase
WP8S18E11_34340	COG0835	chemotaxis
WP8S18E11_34350	COG0840	transmembrane signaling receptor activity
WP8S18E11_34370	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WP8S18E11_34380	COG2201	protein-glutamate methylesterase activity
WP8S18E11_34390	COG1185	polyribonucleotide nucleotidyltransferase activity
WP8S18E11_34400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP8S18E11_34410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP8S18E11_34420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP8S18E11_34430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP8S18E11_34440	COG0195	Participates in both transcription termination and antitermination
WP8S18E11_34450	COG0779	Required for maturation of 30S ribosomal subunits
WP8S18E11_34460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP8S18E11_34470	COG0149	triose-phosphate isomerase activity
WP8S18E11_34480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP8S18E11_34490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP8S18E11_34510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP8S18E11_34520	COG1534	Rna-binding protein
WP8S18E11_34550	COG1360	Flagellar Motor Protein
WP8S18E11_34560	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8S18E11_34570	COG1722	exodeoxyribonuclease VII activity
WP8S18E11_34580	COG0142	geranyltranstransferase activity
WP8S18E11_34590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP8S18E11_34600	COG2814	Major facilitator Superfamily
WP8S18E11_34650	COG0748	coenzyme F420 binding
WP8S18E11_34660	COG3721	Heme iron utilization protein
WP8S18E11_34680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E11_34710	COG3275	phosphorelay sensor kinase activity
WP8S18E11_34720	COG3279	Response regulator of the LytR AlgR family
WP8S18E11_34730	COG1966	Carbon starvation protein
WP8S18E11_34750	COG3340	Belongs to the peptidase S51 family
WP8S18E11_34770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8S18E11_34780	COG0305	Participates in initiation and elongation during chromosome replication
WP8S18E11_34810	COG1047	Peptidyl-prolyl cis-trans
WP8S18E11_34820	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP8S18E11_34840	COG0784	Response regulator, receiver
WP8S18E11_34840	COG0835	chemotaxis
WP8S18E11_34850	COG0429	hydrolase of the alpha beta-hydrolase fold
WP8S18E11_34870	COG3089	Belongs to the UPF0270 family
WP8S18E11_34880	COG3954	Phosphoribulokinase
WP8S18E11_34910	COG1765	OsmC-like protein
WP8S18E11_34990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_35000	COG2313	pseudouridylate synthase activity
WP8S18E11_35010	COG3385	transposase activity
WP8S18E11_35040	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP8S18E11_35050	COG5001	Diguanylate cyclase
WP8S18E11_35050	COG3300	MHYT domain
WP8S18E11_35100	COG0569	domain protein
WP8S18E11_35100	COG2985	domain, Protein
WP8S18E11_35110	COG1272	protein, Hemolysin III
WP8S18E11_35120	COG0076	glutamate decarboxylase activity
WP8S18E11_35130	COG2917	probably involved in intracellular septation
WP8S18E11_35140	COG2350	Protein conserved in bacteria
WP8S18E11_35160	COG1349	DNA-binding transcription factor activity
WP8S18E11_35180	COG2222	sugar isomerase
WP8S18E11_35190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_35210	COG3716	PTS system mannose fructose sorbose family IID component
WP8S18E11_35220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_35230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8S18E11_35250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP8S18E11_35260	COG1381	Involved in DNA repair and RecF pathway recombination
WP8S18E11_35280	COG0571	ribonuclease III activity
WP8S18E11_35290	COG0681	Belongs to the peptidase S26 family
WP8S18E11_35300	COG0481	GTPase activity
WP8S18E11_35320	COG3026	antisigma factor binding
WP8S18E11_35330	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP8S18E11_35340	COG1595	DNA-templated transcription, initiation
WP8S18E11_35350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP8S18E11_35370	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP8S18E11_35380	COG0354	folic acid binding
WP8S18E11_35430	COG4232	protein-disulfide reductase activity
WP8S18E11_35460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8S18E11_35470	COG0191	fructose-bisphosphate aldolase activity
WP8S18E11_35480	COG0126	phosphoglycerate kinase activity
WP8S18E11_35490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S18E11_35500	COG1940	carbohydrate kinase activity
WP8S18E11_35510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP8S18E11_35520	COG2816	NAD+ diphosphatase activity
WP8S18E11_35540	COG4991	sh3 domain protein
WP8S18E11_35550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8S18E11_35610	COG0741	lytic transglycosylase activity
WP8S18E11_35620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP8S18E11_35650	COG0488	(ABC) transporter
WP8S18E11_35670	COG2252	PERMEase
WP8S18E11_35680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8S18E11_35690	COG0840	transmembrane signaling receptor activity
WP8S18E11_35710	COG1278	Cold shock
WP8S18E11_35720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP8S18E11_35740	COG0688	phosphatidylethanolamine metabolic process
WP8S18E11_35750	COG4628	conserved protein (DUF2132)
WP8S18E11_35780	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP8S18E11_35820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP8S18E11_35830	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_35890	COG5433	transposase activity
WP8S18E11_35930	COG3274	enterobacterial common antigen metabolic process
WP8S18E11_35940	COG4695	Portal protein
WP8S18E11_35970	COG5433	transposase activity
WP8S18E11_35980	COG0529	Catalyzes the synthesis of activated sulfate
WP8S18E11_35990	COG0471	metal ion transport
WP8S18E11_35990	COG3273	potassium ion transport
WP8S18E11_36000	COG2895	sulfate adenylyltransferase (ATP) activity
WP8S18E11_36010	COG0175	sulfate reduction
WP8S18E11_36020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8S18E11_36020	COG1648	precorrin-2 dehydrogenase activity
WP8S18E11_36030	COG0330	HflC and HflK could
WP8S18E11_36040	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP8S18E11_36050	COG0840	transmembrane signaling receptor activity
WP8S18E11_36060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP8S18E11_36070	COG0676	glucose-6-phosphate 1-epimerase activity
WP8S18E11_36080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8S18E11_36090	COG1640	4-alpha-glucanotransferase
WP8S18E11_36100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP8S18E11_36200	COG0561	phosphatase activity
WP8S18E11_36230	COG0733	neurotransmitter:sodium symporter activity
WP8S18E11_36250	COG0733	neurotransmitter:sodium symporter activity
WP8S18E11_36260	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP8S18E11_36270	COG2885	chlorophyll binding
WP8S18E11_36280	COG0823	Involved in the tonB-independent uptake of proteins
WP8S18E11_36310	COG0811	peptide transport
WP8S18E11_36320	COG0824	Thioesterase
WP8S18E11_36330	COG3790	cyd operon protein YbgE
WP8S18E11_36340	COG4890	Cyd operon protein YbgT
WP8S18E11_36350	COG1294	oxidase, subunit
WP8S18E11_36370	COG2255	four-way junction helicase activity
WP8S18E11_36380	COG0632	four-way junction helicase activity
WP8S18E11_36420	COG2771	luxR family
WP8S18E11_36450	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP8S18E11_36460	COG4251	negative regulation of phosphorylation
WP8S18E11_36460	COG2203	Gaf domain
WP8S18E11_36460	COG3706	GGDEF domain
WP8S18E11_36460	COG5001	Diguanylate cyclase
WP8S18E11_36480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8S18E11_36500	COG2995	paraquat-inducible protein a
WP8S18E11_36510	COG3008	intermembrane lipid transfer
WP8S18E11_36510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S18E11_36530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8S18E11_36540	COG0442	prolyl-tRNA aminoacylation
WP8S18E11_36550	COG4221	oxidoreductase activity
WP8S18E11_36580	COG1024	Enoyl-CoA hydratase
WP8S18E11_36600	COG0110	maltose O-acetyltransferase activity
WP8S18E11_36620	COG4166	transmembrane transport
WP8S18E11_36640	COG0840	transmembrane signaling receptor activity
WP8S18E11_36650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8S18E11_36660	COG0735	belongs to the Fur family
WP8S18E11_36710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP8S18E11_36720	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_36730	COG2153	protein acetylation
WP8S18E11_36750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8S18E11_36760	COG0557	exoribonuclease II activity
WP8S18E11_36770	COG3706	GGDEF domain
WP8S18E11_36780	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WP8S18E11_36780	COG2885	chlorophyll binding
WP8S18E11_36790	COG3240	lipase activity
WP8S18E11_36800	COG3111	PFAM Bacterial OB fold (BOF) protein
WP8S18E11_36820	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP8S18E11_36830	COG1194	a g-specific adenine glycosylase
WP8S18E11_36840	COG0617	tRNA 3'-terminal CCA addition
WP8S18E11_36880	COG3068	Protein conserved in bacteria
WP8S18E11_36900	COG0739	heme binding
WP8S18E11_36940	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP8S18E11_36950	COG1121	(ABC) transporter
WP8S18E11_36960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP8S18E11_36970	COG0583	DNA-binding transcription factor activity
WP8S18E11_36990	COG1573	uracil-dna glycosylase
WP8S18E11_37020	COG2827	Endonuclease containing a URI domain
WP8S18E11_37050	COG1842	Phage shock protein A
WP8S18E11_37060	COG0204	Acyl-transferase
WP8S18E11_37100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8S18E11_37110	COG0484	heat shock protein binding
WP8S18E11_37150	COG3104	oligopeptide transport
WP8S18E11_37220	COG3150	esterase
WP8S18E11_37240	COG3151	Protein conserved in bacteria
WP8S18E11_37250	COG0494	nUDIX hydrolase
WP8S18E11_37260	COG1538	Outer membrane efflux protein
WP8S18E11_37270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP8S18E11_37270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP8S18E11_37280	COG1560	Kdo2-lipid A biosynthetic process
WP8S18E11_37290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_37290	COG2213	PTS system mannitol-specific
WP8S18E11_37300	COG0246	Mannitol dehydrogenase
WP8S18E11_37310	COG3722	fumarate hydratase activity
WP8S18E11_37370	COG1671	Belongs to the UPF0178 family
WP8S18E11_37380	COG1988	membrane-bound metal-dependent
WP8S18E11_37390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8S18E11_37400	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_37440	COG1575	Belongs to the MenA family. Type 1 subfamily
WP8S18E11_37450	COG1169	isochorismate synthase
WP8S18E11_37460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP8S18E11_37470	COG0596	Alpha beta hydrolase
WP8S18E11_37480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP8S18E11_37490	COG1441	menaquinone biosynthetic process
WP8S18E11_37500	COG0318	PFAM AMP-dependent synthetase and ligase
WP8S18E11_37510	COG3291	Pkd domain containing protein
WP8S18E11_37520	COG2949	membrane
WP8S18E11_37530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP8S18E11_37550	COG0835	chemotaxis
WP8S18E11_37550	COG0784	Response regulator, receiver
WP8S18E11_37570	COG1444	tRNA N-acetyltransferase activity
WP8S18E11_37620	COG1803	Methylglyoxal synthase
WP8S18E11_37630	COG1979	alcohol dehydrogenase
WP8S18E11_37670	COG4221	oxidoreductase activity
WP8S18E11_37740	COG1368	sulfuric ester hydrolase activity
WP8S18E11_37750	COG1522	sequence-specific DNA binding
WP8S18E11_37770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP8S18E11_37790	COG1546	Belongs to the CinA family
WP8S18E11_37790	COG1058	Belongs to the CinA family
WP8S18E11_37810	COG0561	phosphatase activity
WP8S18E11_37830	COG2926	Belongs to the UPF0265 family
WP8S18E11_37840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8S18E11_37850	COG0564	pseudouridine synthase activity
WP8S18E11_37870	COG0110	maltose O-acetyltransferase activity
WP8S18E11_37880	COG0366	Alpha amylase catalytic
WP8S18E11_37890	COG1263	PTS System
WP8S18E11_37890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8S18E11_37930	COG0252	asparaginase activity
WP8S18E11_37940	COG1253	flavin adenine dinucleotide binding
WP8S18E11_37950	COG0586	Pfam SNARE associated Golgi protein
WP8S18E11_37960	COG1686	Belongs to the peptidase S11 family
WP8S18E11_37970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP8S18E11_37990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8S18E11_38010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP8S18E11_38020	COG1546	Belongs to the CinA family
WP8S18E11_38030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP8S18E11_38040	COG4667	esterase of the alpha-beta hydrolase superfamily
WP8S18E11_38060	COG1346	cytolysis
WP8S18E11_38070	COG1380	Effector of murein hydrolase LrgA
WP8S18E11_38080	COG0583	DNA-binding transcription factor activity
WP8S18E11_38120	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP8S18E11_38130	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP8S18E11_38150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP8S18E11_38160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8S18E11_38180	COG0137	argininosuccinate synthase activity
WP8S18E11_38190	COG0165	Argininosuccinate lyase
WP8S18E11_38240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP8S18E11_38250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP8S18E11_38280	COG0477	Major facilitator Superfamily
WP8S18E11_38290	COG0523	cobalamin synthesis protein
WP8S18E11_38310	COG1280	lysine exporter protein (LysE YggA)
WP8S18E11_38340	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_38350	COG2200	EAL domain
WP8S18E11_38360	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP8S18E11_38370	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8S18E11_38380	COG0840	transmembrane signaling receptor activity
WP8S18E11_38400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8S18E11_38410	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8S18E11_38420	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP8S18E11_38430	COG2186	Transcriptional regulator
WP8S18E11_38480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8S18E11_38490	COG1459	type II secretion system
WP8S18E11_38520	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP8S18E11_38530	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP8S18E11_38540	COG0494	nUDIX hydrolase
WP8S18E11_38550	COG0653	protein targeting
WP8S18E11_38570	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP8S18E11_38580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP8S18E11_38590	COG0849	cell division
WP8S18E11_38610	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8S18E11_38620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP8S18E11_38630	COG0772	Belongs to the SEDS family
WP8S18E11_38640	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP8S18E11_38650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8S18E11_38660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP8S18E11_38680	COG0768	penicillin binding
WP8S18E11_38690	COG3116	cell division
WP8S18E11_38700	COG0275	rRNA processing
WP8S18E11_38710	COG2001	Belongs to the MraZ family
WP8S18E11_38720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP8S18E11_38730	COG3107	peptidoglycan biosynthetic process
WP8S18E11_38740	COG0792	nuclease activity
WP8S18E11_38750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8S18E11_38770	COG2969	positive regulation of protein catabolic process
WP8S18E11_38780	COG0625	glutathione transferase activity
WP8S18E11_38790	COG2857	Cytochrome c1
WP8S18E11_38800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP8S18E11_38810	COG0723	plastoquinol--plastocyanin reductase activity
WP8S18E11_38820	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP8S18E11_38830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP8S18E11_38840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP8S18E11_38860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S18E11_38870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8S18E11_38880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_38890	COG1660	Displays ATPase and GTPase activities
WP8S18E11_38900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_38920	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WP8S18E11_38930	COG1137	ATPase activity
WP8S18E11_38940	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP8S18E11_38950	COG3117	lipopolysaccharide transmembrane transporter activity
WP8S18E11_38960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP8S18E11_38970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP8S18E11_38970	COG0517	IMP dehydrogenase activity
WP8S18E11_38980	COG1127	ABC transporter
WP8S18E11_38990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP8S18E11_39000	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8S18E11_39010	COG2854	intermembrane phospholipid transfer
WP8S18E11_39030	COG5007	Belongs to the BolA IbaG family
WP8S18E11_39040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP8S18E11_39050	COG0312	modulator of DNA gyrase
WP8S18E11_39060	COG3028	Belongs to the UPF0307 family
WP8S18E11_39070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP8S18E11_39110	COG1011	Hydrolase
WP8S18E11_39140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP8S18E11_39150	COG0019	diaminopimelate decarboxylase activity
WP8S18E11_39160	COG1965	Belongs to the frataxin family
WP8S18E11_39170	COG0400	carboxylic ester hydrolase activity
WP8S18E11_39180	COG3072	Adenylate cyclase
WP8S18E11_39190	COG0181	hydroxymethylbilane synthase activity
WP8S18E11_39210	COG2959	enzyme of heme biosynthesis
WP8S18E11_39240	COG1494	fructose-1,6-bisphosphatase
WP8S18E11_39330	COG2801	Transposase and inactivated derivatives
WP8S18E11_39370	COG1160	GTP binding
WP8S18E11_39390	COG0582	viral genome integration into host DNA
WP8S18E11_39470	COG0582	viral genome integration into host DNA
WP8S18E11_39490	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S18E11_39500	COG0795	lipopolysaccharide-transporting ATPase activity
WP8S18E11_39510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8S18E11_39520	COG2927	DNA polymerase III (CHI subunit)
WP8S18E11_39570	COG0456	acetyltransferase
WP8S18E11_39570	COG0454	-acetyltransferase
WP8S18E11_39580	COG0753	catalase activity
WP8S18E11_39590	COG3385	transposase activity
WP8S18E11_39640	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8S18E11_39650	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8S18E11_39660	COG5380	lipid catabolic process
WP8S18E11_39690	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WP8S18E11_39700	COG4533	DNA binding
WP8S18E11_39720	COG2873	o-acetylhomoserine
WP8S18E11_39780	COG3842	ATPase activity
WP8S18E11_39800	COG1175	transmembrane transport
WP8S18E11_39850	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8S18E11_39870	COG3706	GGDEF domain
WP8S18E11_39890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8S18E11_39900	COG1074	ATP-dependent DNA helicase activity
WP8S18E11_39910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP8S18E11_39920	COG2259	Doxx family
WP8S18E11_39930	COG1741	Belongs to the pirin family
WP8S18E11_39950	COG0583	DNA-binding transcription factor activity
WP8S18E11_39990	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_40010	COG3706	GGDEF domain
WP8S18E11_40020	COG4771	TonB-dependent receptor
WP8S18E11_40030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8S18E11_40040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S18E11_40050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP8S18E11_40060	COG0049	tRNA binding
WP8S18E11_40070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP8S18E11_40080	COG2168	tRNA wobble position uridine thiolation
WP8S18E11_40090	COG2923	Belongs to the DsrF TusC family
WP8S18E11_40100	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8S18E11_40120	COG2964	Protein conserved in bacteria
WP8S18E11_40130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP8S18E11_40140	COG0085	RNA polymerase activity
WP8S18E11_40150	COG0222	ribosome binding
WP8S18E11_40160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP8S18E11_40170	COG0081	regulation of translation
WP8S18E11_40180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP8S18E11_40190	COG0250	Participates in transcription elongation, termination and antitermination
WP8S18E11_40210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8S18E11_40240	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP8S18E11_40250	COG0569	domain protein
WP8S18E11_40260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E11_40290	COG4191	Histidine kinase
WP8S18E11_40290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_40300	COG3005	denitrification pathway
WP8S18E11_40310	COG0243	molybdopterin cofactor binding
WP8S18E11_40330	COG2205	protein histidine kinase activity
WP8S18E11_40340	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_40410	COG2204	response regulator
WP8S18E11_40430	COG2205	protein histidine kinase activity
WP8S18E11_40460	COG1028	Short-chain dehydrogenase reductase Sdr
WP8S18E11_40470	COG0516	GMP reductase activity
WP8S18E11_40470	COG0517	IMP dehydrogenase activity
WP8S18E11_40480	COG5413	integral membrane protein
WP8S18E11_40500	COG1522	sequence-specific DNA binding
WP8S18E11_40510	COG2502	aspartate--ammonia ligase
WP8S18E11_40520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP8S18E11_40530	COG0542	response to heat
WP8S18E11_40550	COG0564	pseudouridine synthase activity
WP8S18E11_40560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8S18E11_40580	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8S18E11_40600	COG3681	Belongs to the UPF0597 family
WP8S18E11_40610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8S18E11_40620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP8S18E11_40630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP8S18E11_40640	COG1979	alcohol dehydrogenase
WP8S18E11_40650	COG2207	Transcriptional regulator
WP8S18E11_40690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
WP8S18E11_40730	COG0540	Belongs to the ATCase OTCase family
WP8S18E11_40740	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP8S18E11_40750	COG1438	arginine binding
WP8S18E11_40760	COG1288	antiporter activity
WP8S18E11_40770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8S18E11_40850	COG3078	GTPase activator activity
WP8S18E11_40880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP8S18E11_40910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP8S18E11_40920	COG0408	coproporphyrinogen oxidase activity
WP8S18E11_40930	COG0009	L-threonylcarbamoyladenylate synthase
WP8S18E11_40950	COG0551	DNA topoisomerase type I activity
WP8S18E11_40960	COG2922	Belongs to the Smg family
WP8S18E11_40970	COG0758	DNA mediated transformation
WP8S18E11_40980	COG1652	LysM domain
WP8S18E11_40990	COG0242	peptide deformylase activity
WP8S18E11_41000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP8S18E11_41010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8S18E11_41010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8S18E11_41020	COG0569	domain protein
WP8S18E11_41030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E11_41050	COG0174	glutamine synthetase
WP8S18E11_41080	COG2204	response regulator
WP8S18E11_41090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8S18E11_41100	COG1322	Protein conserved in bacteria
WP8S18E11_41140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8S18E11_41150	COG0583	DNA-binding transcription factor activity
WP8S18E11_41160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8S18E11_41160	COG0519	Catalyzes the synthesis of GMP from XMP
WP8S18E11_41190	COG1396	sequence-specific DNA binding
WP8S18E11_41200	COG1012	belongs to the aldehyde dehydrogenase family
WP8S18E11_41220	COG2962	Rard protein
WP8S18E11_41230	COG0840	transmembrane signaling receptor activity
WP8S18E11_41240	COG2391	methyltransferase activity
WP8S18E11_41270	COG0129	dihydroxy-acid dehydratase activity
WP8S18E11_41290	COG3978	acetolactate synthase activity
WP8S18E11_41310	COG0606	chelatase, subunit chli
WP8S18E11_41340	COG2129	metallophosphoesterase
WP8S18E11_41450	COG0606	chelatase, subunit chli
WP8S18E11_41460	COG0204	Acyl-transferase
WP8S18E11_41470	COG0204	Acyl-transferase
WP8S18E11_41480	COG1683	Conserved Protein
WP8S18E11_41500	COG1335	isochorismatase
WP8S18E11_41520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8S18E11_41530	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP8S18E11_41550	COG3084	Protein conserved in bacteria
WP8S18E11_41560	COG5001	Diguanylate cyclase
WP8S18E11_41560	COG4251	negative regulation of phosphorylation
WP8S18E11_41560	COG3706	GGDEF domain
WP8S18E11_41560	COG2203	Gaf domain
WP8S18E11_41590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP8S18E11_41610	COG1561	YicC-like family, N-terminal region
WP8S18E11_41620	COG1309	transcriptional regulator
WP8S18E11_41630	COG1538	Outer membrane efflux protein
WP8S18E11_41650	COG2814	Major facilitator Superfamily
WP8S18E11_41660	COG0583	DNA-binding transcription factor activity
WP8S18E11_41700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP8S18E11_41710	COG0385	Bile acid
WP8S18E11_41720	COG3328	transposase activity
WP8S18E11_41740	COG1609	Transcriptional regulator
WP8S18E11_41750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP8S18E11_41760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E11_41760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8S18E11_41770	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP8S18E11_41780	COG3074	FtsZ-dependent cytokinesis
WP8S18E11_41800	COG1045	serine acetyltransferase
WP8S18E11_41820	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_41830	COG2205	protein histidine kinase activity
WP8S18E11_41840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP8S18E11_41850	COG0534	Mate efflux family protein
WP8S18E11_41870	COG3385	transposase activity
WP8S18E11_41890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8S18E11_41900	COG2937	Belongs to the GPAT DAPAT family
WP8S18E11_41910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP8S18E11_41920	COG3161	chorismate lyase activity
WP8S18E11_41970	COG0604	alcohol dehydrogenase
WP8S18E11_41980	COG1609	Transcriptional regulator
WP8S18E11_41990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8S18E11_42020	COG1519	Transferase
WP8S18E11_42030	COG0859	PFAM glycosyl transferase family 9
WP8S18E11_42040	COG0463	Glycosyl transferase, family 2
WP8S18E11_42050	COG0859	PFAM glycosyl transferase family 9
WP8S18E11_42060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP8S18E11_42070	COG2990	Protein conserved in bacteria
WP8S18E11_42080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP8S18E11_42100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP8S18E11_42110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP8S18E11_42120	COG2003	Belongs to the UPF0758 family
WP8S18E11_42130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP8S18E11_42140	COG0756	dUTP diphosphatase activity
WP8S18E11_42150	COG1309	transcriptional regulator
WP8S18E11_42160	COG0668	transmembrane transport
WP8S18E11_42170	COG0166	Belongs to the GPI family
WP8S18E11_42180	COG3385	transposase activity
WP8S18E11_42190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP8S18E11_42230	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8S18E11_42230	COG1042	CoA-binding domain protein
WP8S18E11_42230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8S18E11_42250	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP8S18E11_42260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8S18E11_42270	COG1739	Uncharacterized protein family UPF0029
WP8S18E11_42280	COG0006	proline dipeptidase activity
WP8S18E11_42290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8S18E11_42300	COG1024	Enoyl-CoA hydratase
WP8S18E11_42300	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8S18E11_42310	COG0183	Belongs to the thiolase family
WP8S18E11_42320	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_42330	COG2205	protein histidine kinase activity
WP8S18E11_42360	COG0425	Belongs to the sulfur carrier protein TusA family
WP8S18E11_42370	COG0251	oxidation-reduction process
WP8S18E11_42380	COG2885	chlorophyll binding
WP8S18E11_42410	COG2818	Glycosylase
WP8S18E11_42420	COG0752	glycyl-tRNA synthetase alpha subunit
WP8S18E11_42430	COG0751	glycine-tRNA ligase activity
WP8S18E11_42450	COG2200	EAL domain
WP8S18E11_42500	COG1609	Transcriptional regulator
WP8S18E11_42560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8S18E11_42590	COG2960	long-chain fatty acid transporting porin activity
WP8S18E11_42600	COG5001	Diguanylate cyclase
WP8S18E11_42600	COG5002	protein histidine kinase activity
WP8S18E11_42620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP8S18E11_42650	COG3118	belongs to the thioredoxin family
WP8S18E11_42660	COG0513	Belongs to the DEAD box helicase family
WP8S18E11_42670	COG0248	Ppx GppA phosphatase
WP8S18E11_42690	COG0742	ribosomal rna small subunit methyltransferase
WP8S18E11_42720	COG3469	chitinase activity
WP8S18E11_42740	COG0084	hydrolase, TatD family'
WP8S18E11_42750	COG0805	protein transport
WP8S18E11_42760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S18E11_42770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8S18E11_42780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP8S18E11_42790	COG3165	ubiquinone biosynthetic process from chorismate
WP8S18E11_42800	COG2226	methyltransferase
WP8S18E11_42810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP8S18E11_42820	COG0402	S-adenosylhomocysteine deaminase activity
WP8S18E11_42830	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP8S18E11_42850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP8S18E11_42880	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP8S18E11_42890	COG0848	biopolymer transport protein
WP8S18E11_42900	COG0811	peptide transport
WP8S18E11_42910	COG0811	peptide transport
WP8S18E11_42930	COG2771	luxR family
WP8S18E11_42960	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP8S18E11_43080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP8S18E11_43090	COG1349	DNA-binding transcription factor activity
WP8S18E11_43100	COG0745	RESPONSE REGULATOR receiver
WP8S18E11_43110	COG2205	protein histidine kinase activity
WP8S18E11_43130	COG4452	Inner membrane protein CreD
WP8S18E11_43140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP8S18E11_43150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP8S18E11_43160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP8S18E11_43170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP8S18E11_43180	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP8S18E11_43190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP8S18E11_43200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP8S18E11_43220	COG0356	it plays a direct role in the translocation of protons across the membrane
WP8S18E11_43240	COG1475	DNA binding
WP8S18E11_43250	COG1192	Involved in chromosome partitioning
WP8S18E11_43260	COG0357	Ribosomal RNA small subunit methyltransferase G
WP8S18E11_43270	COG0445	tRNA wobble uridine modification
WP8S18E11_43280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP8S18E11_43290	COG4774	siderophore transport
WP8S18E11_43300	COG4615	Cyclic peptide transporter
WP8S18E11_43310	COG1120	ATPase activity
WP8S18E11_43320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8S18E11_43330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8S18E11_43340	COG3550	peptidyl-serine autophosphorylation
WP8S18E11_43410	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP8S18E11_43430	COG3012	SEC-C Motif Domain Protein
WP8S18E11_43430	COG3318	Belongs to the UPF0149 family
WP8S18E11_43480	COG3039	Transposase
WP8S18E11_43520	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_43530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP8S18E11_43540	COG0706	membrane insertase activity
WP8S18E11_43550	COG0594	ribonuclease P activity
WP8S18E11_43560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP8S18E11_P10180	COG4974	Belongs to the 'phage' integrase family
WP8S18E11_P20010	COG1192	Involved in chromosome partitioning