locus-tag	class	description
WP8W19C03_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WP8W19C03_00020	COG0592	DNA-directed DNA polymerase activity
WP8W19C03_00040	COG0187	DNA topoisomerase II activity
WP8W19C03_00060	COG2378	regulation of single-species biofilm formation
WP8W19C03_00080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
WP8W19C03_00090	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8W19C03_00100	COG0071	Belongs to the small heat shock protein (HSP20) family
WP8W19C03_00110	COG3977	Valine--pyruvate aminotransferase
WP8W19C03_00150	COG2814	Major facilitator Superfamily
WP8W19C03_00160	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_00170	COG2205	protein histidine kinase activity
WP8W19C03_00220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8W19C03_00230	COG4191	Histidine kinase
WP8W19C03_00230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_00240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_00250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_00260	COG1309	transcriptional regulator
WP8W19C03_00280	COG0561	phosphatase activity
WP8W19C03_00290	COG2267	carboxylic ester hydrolase activity
WP8W19C03_00310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8W19C03_00320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8W19C03_00330	COG1758	RNA polymerase activity
WP8W19C03_00340	COG0194	GDP metabolic process
WP8W19C03_00350	COG0859	PFAM glycosyl transferase family 9
WP8W19C03_00360	COG3642	lipopolysaccharide core region biosynthetic process
WP8W19C03_00440	COG0589	response to stress
WP8W19C03_00450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8W19C03_00460	COG1528	Iron-storage protein
WP8W19C03_00470	COG2081	HI0933 family
WP8W19C03_00480	COG3275	phosphorelay sensor kinase activity
WP8W19C03_00490	COG3279	Response regulator of the LytR AlgR family
WP8W19C03_00500	COG2223	nitrite transmembrane transporter activity
WP8W19C03_00510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WP8W19C03_00520	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WP8W19C03_00550	COG0583	DNA-binding transcription factor activity
WP8W19C03_00570	COG3385	transposase activity
WP8W19C03_00620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WP8W19C03_00630	COG2166	iron-sulfur cluster assembly
WP8W19C03_00640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
WP8W19C03_00670	COG3245	cytochrome
WP8W19C03_00680	COG1063	alcohol dehydrogenase
WP8W19C03_00710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8W19C03_00720	COG0438	transferase activity, transferring glycosyl groups
WP8W19C03_00750	COG0110	maltose O-acetyltransferase activity
WP8W19C03_00770	COG0604	alcohol dehydrogenase
WP8W19C03_00900	COG0210	DNA helicase
WP8W19C03_00950	COG0737	Belongs to the 5'-nucleotidase family
WP8W19C03_00970	COG2239	Acts as a magnesium transporter
WP8W19C03_00980	COG1648	precorrin-2 dehydrogenase activity
WP8W19C03_00980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8W19C03_00990	COG2116	formate transmembrane transporter activity
WP8W19C03_01010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8W19C03_01020	COG0842	Transport permease protein
WP8W19C03_01030	COG0842	Transport permease protein
WP8W19C03_01040	COG1131	(ABC) transporter
WP8W19C03_01050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_01070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WP8W19C03_01080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
WP8W19C03_01100	COG0018	arginyl-trna synthetase
WP8W19C03_01120	COG1595	DNA-templated transcription, initiation
WP8W19C03_01140	COG1968	undecaprenyl-diphosphatase activity
WP8W19C03_01150	COG2017	converts alpha-aldose to the beta-anomer
WP8W19C03_01160	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
WP8W19C03_01180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8W19C03_01190	COG1609	Transcriptional regulator
WP8W19C03_01200	COG3250	beta-galactosidase activity
WP8W19C03_01220	COG1129	ABC transporter
WP8W19C03_01230	COG4211	Belongs to the binding-protein-dependent transport system permease family
WP8W19C03_01250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8W19C03_01280	COG0366	Alpha amylase catalytic
WP8W19C03_01310	COG0443	Heat shock 70 kDa protein
WP8W19C03_01320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8W19C03_01330	COG3045	CreA protein
WP8W19C03_01370	COG0174	glutamine synthetase
WP8W19C03_01410	COG3842	ATPase activity
WP8W19C03_01420	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8W19C03_01430	COG1177	transmembrane transport
WP8W19C03_01440	COG2258	MOSC domain
WP8W19C03_01460	COG2050	protein possibly involved in aromatic compounds catabolism
WP8W19C03_01470	COG0514	ATP-dependent DNA helicase (RecQ)
WP8W19C03_01490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
WP8W19C03_01510	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
WP8W19C03_01520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8W19C03_01550	COG0254	rRNA binding
WP8W19C03_01560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WP8W19C03_01580	COG0702	epimerase
WP8W19C03_01590	COG0814	amino acid
WP8W19C03_01600	COG0281	malic enzyme
WP8W19C03_01610	COG1295	ribonuclease BN
WP8W19C03_01620	COG1490	D-aminoacyl-tRNA deacylase activity
WP8W19C03_01630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WP8W19C03_01640	COG0456	acetyltransferase
WP8W19C03_01660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WP8W19C03_01670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8W19C03_01680	COG2610	gluconate transmembrane transporter activity
WP8W19C03_01690	COG3265	gluconokinase activity
WP8W19C03_01700	COG0129	dihydroxy-acid dehydratase activity
WP8W19C03_01710	COG0800	Aldolase
WP8W19C03_01720	COG1609	Transcriptional regulator
WP8W19C03_01740	COG4942	peptidase
WP8W19C03_01750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
WP8W19C03_01760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8W19C03_01770	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
WP8W19C03_01780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
WP8W19C03_01790	COG0316	Belongs to the HesB IscA family
WP8W19C03_01790	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
WP8W19C03_01800	COG1040	competence protein
WP8W19C03_01810	COG0596	Alpha beta hydrolase
WP8W19C03_01850	COG2183	response to ionizing radiation
WP8W19C03_01860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8W19C03_01870	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_01900	COG0051	transcription antitermination factor activity, RNA binding
WP8W19C03_01910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WP8W19C03_01920	COG0088	Forms part of the polypeptide exit tunnel
WP8W19C03_01930	COG0089	rRNA binding
WP8W19C03_01940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
WP8W19C03_01950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
WP8W19C03_01960	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
WP8W19C03_01970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
WP8W19C03_01980	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WP8W19C03_01990	COG0255	Belongs to the universal ribosomal protein uL29 family
WP8W19C03_02000	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WP8W19C03_02010	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WP8W19C03_02020	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
WP8W19C03_02030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
WP8W19C03_02040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
WP8W19C03_02050	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
WP8W19C03_02060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
WP8W19C03_02070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
WP8W19C03_02080	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
WP8W19C03_02090	COG1841	ribosomal large subunit assembly
WP8W19C03_02100	COG0200	Binds to the 23S rRNA
WP8W19C03_02110	COG0201	protein transport
WP8W19C03_02120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WP8W19C03_02130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
WP8W19C03_02140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WP8W19C03_02150	COG0202	RNA polymerase activity
WP8W19C03_02160	COG0203	ribosomal protein L17
WP8W19C03_02170	COG4771	TonB-dependent receptor
WP8W19C03_02200	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_02230	COG0583	DNA-binding transcription factor activity
WP8W19C03_02250	COG1741	Belongs to the pirin family
WP8W19C03_02260	COG2259	Doxx family
WP8W19C03_02270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WP8W19C03_02280	COG1074	ATP-dependent DNA helicase activity
WP8W19C03_02290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8W19C03_02310	COG5433	transposase activity
WP8W19C03_02330	COG3706	GGDEF domain
WP8W19C03_02400	COG1175	transmembrane transport
WP8W19C03_02420	COG3842	ATPase activity
WP8W19C03_02480	COG2873	o-acetylhomoserine
WP8W19C03_02500	COG4533	DNA binding
WP8W19C03_02540	COG5380	lipid catabolic process
WP8W19C03_02550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8W19C03_02560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8W19C03_02610	COG0753	catalase activity
WP8W19C03_02670	COG2927	DNA polymerase III (CHI subunit)
WP8W19C03_02680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8W19C03_02690	COG0795	lipopolysaccharide-transporting ATPase activity
WP8W19C03_02700	COG0795	lipopolysaccharide-transporting ATPase activity
WP8W19C03_02900	COG1494	fructose-1,6-bisphosphatase
WP8W19C03_02930	COG2959	enzyme of heme biosynthesis
WP8W19C03_02950	COG0181	hydroxymethylbilane synthase activity
WP8W19C03_02960	COG3072	Adenylate cyclase
WP8W19C03_02970	COG0400	carboxylic ester hydrolase activity
WP8W19C03_02980	COG1965	Belongs to the frataxin family
WP8W19C03_02990	COG0019	diaminopimelate decarboxylase activity
WP8W19C03_03000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WP8W19C03_03030	COG1011	Hydrolase
WP8W19C03_03070	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WP8W19C03_03080	COG3028	Belongs to the UPF0307 family
WP8W19C03_03090	COG0312	modulator of DNA gyrase
WP8W19C03_03100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
WP8W19C03_03110	COG5007	Belongs to the BolA IbaG family
WP8W19C03_03130	COG2854	intermembrane phospholipid transfer
WP8W19C03_03140	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8W19C03_03150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WP8W19C03_03160	COG1127	ABC transporter
WP8W19C03_03170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
WP8W19C03_03170	COG0517	IMP dehydrogenase activity
WP8W19C03_03180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WP8W19C03_03190	COG3117	lipopolysaccharide transmembrane transporter activity
WP8W19C03_03200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
WP8W19C03_03210	COG1137	ATPase activity
WP8W19C03_03240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_03250	COG1660	Displays ATPase and GTPase activities
WP8W19C03_03260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_03270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_03270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_03280	COG3711	transcriptional antiterminator
WP8W19C03_03280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_03310	COG3964	amidohydrolase
WP8W19C03_03370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8W19C03_03380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WP8W19C03_03400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WP8W19C03_03410	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WP8W19C03_03420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WP8W19C03_03430	COG0723	plastoquinol--plastocyanin reductase activity
WP8W19C03_03440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WP8W19C03_03450	COG2857	Cytochrome c1
WP8W19C03_03460	COG0625	glutathione transferase activity
WP8W19C03_03470	COG2969	positive regulation of protein catabolic process
WP8W19C03_03490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8W19C03_03500	COG0792	nuclease activity
WP8W19C03_03510	COG3107	peptidoglycan biosynthetic process
WP8W19C03_03520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
WP8W19C03_03530	COG2001	Belongs to the MraZ family
WP8W19C03_03540	COG0275	rRNA processing
WP8W19C03_03550	COG3116	cell division
WP8W19C03_03560	COG0768	penicillin binding
WP8W19C03_03580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WP8W19C03_03590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8W19C03_03600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WP8W19C03_03610	COG0772	Belongs to the SEDS family
WP8W19C03_03620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WP8W19C03_03630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8W19C03_03650	COG0849	cell division
WP8W19C03_03660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
WP8W19C03_03670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WP8W19C03_03690	COG0653	protein targeting
WP8W19C03_03700	COG0494	nUDIX hydrolase
WP8W19C03_03710	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WP8W19C03_03720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
WP8W19C03_03740	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WP8W19C03_03750	COG1459	type II secretion system
WP8W19C03_03760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8W19C03_03800	COG2186	Transcriptional regulator
WP8W19C03_03810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WP8W19C03_03820	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8W19C03_03830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WP8W19C03_03850	COG0840	transmembrane signaling receptor activity
WP8W19C03_03860	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8W19C03_03870	COG1049	propionate catabolic process, 2-methylcitrate cycle
WP8W19C03_03880	COG2200	EAL domain
WP8W19C03_03900	COG0523	cobalamin synthesis protein
WP8W19C03_03910	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_03940	COG0477	Major facilitator Superfamily
WP8W19C03_03970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
WP8W19C03_03980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
WP8W19C03_04010	COG0165	Argininosuccinate lyase
WP8W19C03_04020	COG0137	argininosuccinate synthase activity
WP8W19C03_04040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8W19C03_04050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WP8W19C03_04070	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WP8W19C03_04080	COG0110	maltose O-acetyltransferase activity
WP8W19C03_04100	COG3706	GGDEF domain
WP8W19C03_04110	COG0814	amino acid
WP8W19C03_04120	COG3932	Exopolysaccharide synthesis, ExoD
WP8W19C03_04140	COG3706	GGDEF domain
WP8W19C03_04150	COG0004	ammonium transporteR
WP8W19C03_04160	COG3133	Outer membrane lipoprotein
WP8W19C03_04170	COG0456	acetyltransferase
WP8W19C03_04220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WP8W19C03_04250	COG0494	nUDIX hydrolase
WP8W19C03_04260	COG0628	permease
WP8W19C03_04280	COG5433	transposase activity
WP8W19C03_04290	COG3284	Transcriptional regulator
WP8W19C03_04320	COG1461	Dihydroxyacetone kinase
WP8W19C03_04330	COG2376	Dihydroxyacetone kinase
WP8W19C03_04340	COG2252	PERMEase
WP8W19C03_04350	COG1278	Cold shock
WP8W19C03_04360	COG3039	Transposase
WP8W19C03_04380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
WP8W19C03_04480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8W19C03_04540	COG2197	response regulator
WP8W19C03_04610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
WP8W19C03_04620	COG3706	GGDEF domain
WP8W19C03_04630	COG3047	cAMP biosynthetic process
WP8W19C03_04640	COG0840	transmembrane signaling receptor activity
WP8W19C03_04690	COG3135	benzoate transporter
WP8W19C03_04700	COG1396	sequence-specific DNA binding
WP8W19C03_04730	COG2926	Belongs to the UPF0265 family
WP8W19C03_04750	COG0561	phosphatase activity
WP8W19C03_04770	COG1546	Belongs to the CinA family
WP8W19C03_04770	COG1058	Belongs to the CinA family
WP8W19C03_04790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
WP8W19C03_04810	COG1522	sequence-specific DNA binding
WP8W19C03_04820	COG1368	sulfuric ester hydrolase activity
WP8W19C03_04890	COG4221	oxidoreductase activity
WP8W19C03_04920	COG1979	alcohol dehydrogenase
WP8W19C03_04930	COG1803	Methylglyoxal synthase
WP8W19C03_04970	COG1444	tRNA N-acetyltransferase activity
WP8W19C03_04990	COG0784	Response regulator, receiver
WP8W19C03_04990	COG0835	chemotaxis
WP8W19C03_05010	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WP8W19C03_05020	COG2949	membrane
WP8W19C03_05030	COG3291	Pkd domain containing protein
WP8W19C03_05040	COG0318	PFAM AMP-dependent synthetase and ligase
WP8W19C03_05050	COG1441	menaquinone biosynthetic process
WP8W19C03_05060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
WP8W19C03_05070	COG0596	Alpha beta hydrolase
WP8W19C03_05080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
WP8W19C03_05090	COG1169	isochorismate synthase
WP8W19C03_05100	COG1575	Belongs to the MenA family. Type 1 subfamily
WP8W19C03_05140	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_05150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8W19C03_05160	COG1988	membrane-bound metal-dependent
WP8W19C03_05170	COG1671	Belongs to the UPF0178 family
WP8W19C03_05210	COG0484	heat shock protein binding
WP8W19C03_05230	COG3722	fumarate hydratase activity
WP8W19C03_05240	COG0246	Mannitol dehydrogenase
WP8W19C03_05250	COG2213	PTS system mannitol-specific
WP8W19C03_05250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_05260	COG1560	Kdo2-lipid A biosynthetic process
WP8W19C03_05270	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WP8W19C03_05270	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WP8W19C03_05280	COG1538	Outer membrane efflux protein
WP8W19C03_05290	COG0494	nUDIX hydrolase
WP8W19C03_05300	COG3151	Protein conserved in bacteria
WP8W19C03_05320	COG3150	esterase
WP8W19C03_05370	COG3104	oligopeptide transport
WP8W19C03_05430	COG2084	Dehydrogenase
WP8W19C03_05440	COG0583	DNA-binding transcription factor activity
WP8W19C03_05450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8W19C03_05490	COG0204	Acyl-transferase
WP8W19C03_05500	COG1842	Phage shock protein A
WP8W19C03_05530	COG2827	Endonuclease containing a URI domain
WP8W19C03_05560	COG1573	uracil-dna glycosylase
WP8W19C03_05570	COG0697	spore germination
WP8W19C03_05580	COG0583	DNA-binding transcription factor activity
WP8W19C03_05590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WP8W19C03_05600	COG1121	(ABC) transporter
WP8W19C03_05610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
WP8W19C03_05650	COG0739	heme binding
WP8W19C03_05670	COG3068	Protein conserved in bacteria
WP8W19C03_05710	COG0617	tRNA 3'-terminal CCA addition
WP8W19C03_05720	COG1194	a g-specific adenine glycosylase
WP8W19C03_05730	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
WP8W19C03_05750	COG3111	PFAM Bacterial OB fold (BOF) protein
WP8W19C03_05760	COG3240	lipase activity
WP8W19C03_05770	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
WP8W19C03_05770	COG2885	chlorophyll binding
WP8W19C03_05780	COG3706	GGDEF domain
WP8W19C03_05790	COG0557	exoribonuclease II activity
WP8W19C03_05800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WP8W19C03_05820	COG2153	protein acetylation
WP8W19C03_05830	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_05840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WP8W19C03_05890	COG0735	belongs to the Fur family
WP8W19C03_05900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8W19C03_05910	COG0840	transmembrane signaling receptor activity
WP8W19C03_05930	COG4166	transmembrane transport
WP8W19C03_05950	COG0110	maltose O-acetyltransferase activity
WP8W19C03_05970	COG1024	Enoyl-CoA hydratase
WP8W19C03_06000	COG4221	oxidoreductase activity
WP8W19C03_06010	COG0442	prolyl-tRNA aminoacylation
WP8W19C03_06020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8W19C03_06040	COG3008	intermembrane lipid transfer
WP8W19C03_06040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WP8W19C03_06050	COG2995	paraquat-inducible protein a
WP8W19C03_06070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8W19C03_06090	COG5001	Diguanylate cyclase
WP8W19C03_06090	COG3706	GGDEF domain
WP8W19C03_06090	COG2203	Gaf domain
WP8W19C03_06090	COG4251	negative regulation of phosphorylation
WP8W19C03_06100	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
WP8W19C03_06130	COG2771	luxR family
WP8W19C03_06150	COG0840	transmembrane signaling receptor activity
WP8W19C03_06160	COG0632	four-way junction helicase activity
WP8W19C03_06170	COG2255	four-way junction helicase activity
WP8W19C03_06190	COG1294	oxidase, subunit
WP8W19C03_06200	COG4890	Cyd operon protein YbgT
WP8W19C03_06210	COG3790	cyd operon protein YbgE
WP8W19C03_06220	COG0824	Thioesterase
WP8W19C03_06230	COG0811	peptide transport
WP8W19C03_06260	COG0823	Involved in the tonB-independent uptake of proteins
WP8W19C03_06270	COG2885	chlorophyll binding
WP8W19C03_06280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
WP8W19C03_06290	COG0733	neurotransmitter:sodium symporter activity
WP8W19C03_06310	COG0733	neurotransmitter:sodium symporter activity
WP8W19C03_06340	COG0561	phosphatase activity
WP8W19C03_06440	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
WP8W19C03_06450	COG1640	4-alpha-glucanotransferase
WP8W19C03_06460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8W19C03_06470	COG0676	glucose-6-phosphate 1-epimerase activity
WP8W19C03_06480	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WP8W19C03_06490	COG0840	transmembrane signaling receptor activity
WP8W19C03_06500	COG1585	Membrane protein implicated in regulation of membrane protease activity
WP8W19C03_06510	COG0330	HflC and HflK could
WP8W19C03_06520	COG1648	precorrin-2 dehydrogenase activity
WP8W19C03_06520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8W19C03_06530	COG0175	sulfate reduction
WP8W19C03_06540	COG2895	sulfate adenylyltransferase (ATP) activity
WP8W19C03_06550	COG3273	potassium ion transport
WP8W19C03_06550	COG0471	metal ion transport
WP8W19C03_06560	COG0529	Catalyzes the synthesis of activated sulfate
WP8W19C03_06580	COG5433	transposase activity
WP8W19C03_06600	COG0840	transmembrane signaling receptor activity
WP8W19C03_06640	COG1136	(ABC) transporter
WP8W19C03_06670	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
WP8W19C03_06700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WP8W19C03_06710	COG3437	response regulator, receiver
WP8W19C03_06710	COG0784	Response regulator, receiver
WP8W19C03_06730	COG2076	Multidrug Resistance protein
WP8W19C03_06740	COG2076	Multidrug Resistance protein
WP8W19C03_06750	COG0346	lactoylglutathione lyase activity
WP8W19C03_06760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8W19C03_06770	COG1643	Atp-dependent helicase
WP8W19C03_06790	COG1489	DNA binding
WP8W19C03_06800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
WP8W19C03_06810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8W19C03_06830	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WP8W19C03_06840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
WP8W19C03_06850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
WP8W19C03_06910	COG1924	4 iron, 4 sulfur cluster binding
WP8W19C03_06920	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
WP8W19C03_06930	COG0842	Transport permease protein
WP8W19C03_06940	COG1131	(ABC) transporter
WP8W19C03_06970	COG0163	prenyltransferase activity
WP8W19C03_06980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WP8W19C03_06990	COG0671	phosphoesterase, PA-phosphatase related
WP8W19C03_07000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WP8W19C03_07020	COG1151	hydroxylamine reductase activity
WP8W19C03_07030	COG0783	Belongs to the Dps family
WP8W19C03_07040	COG3023	N-Acetylmuramoyl-L-alanine amidase
WP8W19C03_07050	COG4807	Protein conserved in bacteria
WP8W19C03_07070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
WP8W19C03_07080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WP8W19C03_07090	COG3956	TIGRFAM MazG family protein
WP8W19C03_07100	COG0504	CTP synthase activity
WP8W19C03_07110	COG0148	phosphopyruvate hydratase activity
WP8W19C03_07200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WP8W19C03_07220	COG0488	(ABC) transporter
WP8W19C03_07230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8W19C03_07230	COG0617	tRNA 3'-terminal CCA addition
WP8W19C03_07230	COG0517	IMP dehydrogenase activity
WP8W19C03_07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8W19C03_07290	COG1794	racemase activity, acting on amino acids and derivatives
WP8W19C03_07310	COG2731	YhcH YjgK YiaL family protein
WP8W19C03_07330	COG0668	transmembrane transport
WP8W19C03_07340	COG1376	ErfK ybiS ycfS ynhG family protein
WP8W19C03_07360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8W19C03_07370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WP8W19C03_07380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WP8W19C03_07400	COG0585	pseudouridine synthase activity
WP8W19C03_07410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WP8W19C03_07420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WP8W19C03_07430	COG1238	metal cluster binding
WP8W19C03_07460	COG1902	pentaerythritol trinitrate reductase activity
WP8W19C03_07480	COG2852	Protein conserved in bacteria
WP8W19C03_07500	COG2957	Belongs to the agmatine deiminase family
WP8W19C03_07510	COG0154	amidase activity
WP8W19C03_07530	COG3039	Transposase
WP8W19C03_07540	COG5433	transposase activity
WP8W19C03_07590	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_07600	COG2203	Gaf domain
WP8W19C03_07600	COG2199	diguanylate cyclase activity
WP8W19C03_07620	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
WP8W19C03_07630	COG1858	cytochrome C peroxidase
WP8W19C03_07740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WP8W19C03_07760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8W19C03_07770	COG4991	sh3 domain protein
WP8W19C03_07790	COG2816	NAD+ diphosphatase activity
WP8W19C03_07800	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WP8W19C03_07810	COG1940	carbohydrate kinase activity
WP8W19C03_07820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WP8W19C03_07830	COG0126	phosphoglycerate kinase activity
WP8W19C03_07840	COG0191	fructose-bisphosphate aldolase activity
WP8W19C03_07850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_07940	COG0354	folic acid binding
WP8W19C03_07950	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
WP8W19C03_07970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WP8W19C03_07980	COG1595	DNA-templated transcription, initiation
WP8W19C03_07990	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
WP8W19C03_08000	COG3026	antisigma factor binding
WP8W19C03_08020	COG0481	GTPase activity
WP8W19C03_08030	COG0681	Belongs to the peptidase S26 family
WP8W19C03_08060	COG1381	Involved in DNA repair and RecF pathway recombination
WP8W19C03_08070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
WP8W19C03_08090	COG2350	Protein conserved in bacteria
WP8W19C03_08100	COG2917	probably involved in intracellular septation
WP8W19C03_08110	COG0076	glutamate decarboxylase activity
WP8W19C03_08120	COG1272	protein, Hemolysin III
WP8W19C03_08130	COG2985	domain, Protein
WP8W19C03_08130	COG0569	domain protein
WP8W19C03_08170	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
WP8W19C03_08190	COG0653	protein targeting
WP8W19C03_08220	COG2801	Transposase and inactivated derivatives
WP8W19C03_08280	COG4974	Belongs to the 'phage' integrase family
WP8W19C03_08340	COG0582	viral genome integration into host DNA
WP8W19C03_08360	COG1858	cytochrome C peroxidase
WP8W19C03_08380	COG2313	pseudouridylate synthase activity
WP8W19C03_08390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8W19C03_08470	COG1765	OsmC-like protein
WP8W19C03_08500	COG3954	Phosphoribulokinase
WP8W19C03_08510	COG3089	Belongs to the UPF0270 family
WP8W19C03_08520	COG2203	Gaf domain
WP8W19C03_08520	COG3706	GGDEF domain
WP8W19C03_08520	COG4251	negative regulation of phosphorylation
WP8W19C03_08520	COG5001	Diguanylate cyclase
WP8W19C03_08530	COG0429	hydrolase of the alpha beta-hydrolase fold
WP8W19C03_08540	COG0835	chemotaxis
WP8W19C03_08540	COG0784	Response regulator, receiver
WP8W19C03_08560	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
WP8W19C03_08570	COG1047	Peptidyl-prolyl cis-trans
WP8W19C03_08610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8W19C03_08640	COG1966	Carbon starvation protein
WP8W19C03_08650	COG3279	Response regulator of the LytR AlgR family
WP8W19C03_08660	COG3275	phosphorelay sensor kinase activity
WP8W19C03_08690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8W19C03_08710	COG3721	Heme iron utilization protein
WP8W19C03_08720	COG0748	coenzyme F420 binding
WP8W19C03_08780	COG2814	Major facilitator Superfamily
WP8W19C03_08800	COG3655	Transcriptional regulator
WP8W19C03_08820	COG0784	Response regulator, receiver
WP8W19C03_08820	COG2205	protein histidine kinase activity
WP8W19C03_08820	COG5002	protein histidine kinase activity
WP8W19C03_08840	COG3706	GGDEF domain
WP8W19C03_08870	COG3397	chitin binding
WP8W19C03_08910	COG0835	chemotaxis
WP8W19C03_08910	COG0784	Response regulator, receiver
WP8W19C03_08920	COG2755	lipolytic protein G-D-S-L family
WP8W19C03_08930	COG4181	ATPase activity
WP8W19C03_08940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
WP8W19C03_08950	COG1090	epimerase
WP8W19C03_08960	COG2200	EAL domain
WP8W19C03_08970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8W19C03_08980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WP8W19C03_08990	COG3171	Protein conserved in bacteria
WP8W19C03_09000	COG2066	Belongs to the glutaminase family
WP8W19C03_09010	COG2897	thiosulfate sulfurtransferase activity
WP8W19C03_09040	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8W19C03_09060	COG2966	Psort location CytoplasmicMembrane, score
WP8W19C03_09070	COG3610	response to peptide
WP8W19C03_09100	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
WP8W19C03_09110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP8W19C03_09120	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
WP8W19C03_09130	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WP8W19C03_09150	COG0786	glutamate:sodium symporter activity
WP8W19C03_09160	COG0252	asparaginase activity
WP8W19C03_09170	COG3139	Protein of unknown function (DUF1315)
WP8W19C03_09210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WP8W19C03_09220	COG0321	lipoyl(octanoyl) transferase activity
WP8W19C03_09230	COG2921	Belongs to the UPF0250 family
WP8W19C03_09240	COG1686	Belongs to the peptidase S11 family
WP8W19C03_09250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP8W19C03_09260	COG2951	lytic endotransglycosylase activity
WP8W19C03_09270	COG0772	Belongs to the SEDS family
WP8W19C03_09280	COG0768	penicillin binding
WP8W19C03_09290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WP8W19C03_09300	COG0799	negative regulation of ribosome biogenesis
WP8W19C03_09310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
WP8W19C03_09340	COG0495	leucyl-tRNA aminoacylation
WP8W19C03_09350	COG2888	peptidyl-tyrosine sulfation
WP8W19C03_09360	COG0312	modulator of DNA gyrase
WP8W19C03_09380	COG0716	FMN binding
WP8W19C03_09390	COG4974	Belongs to the 'phage' integrase family
WP8W19C03_09400	COG1970	mechanosensitive ion channel activity
WP8W19C03_09430	COG0789	Transcriptional regulator
WP8W19C03_09440	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WP8W19C03_09450	COG4535	Mg2 and Co2 transporter CorC
WP8W19C03_09460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
WP8W19C03_09470	COG1702	phosphate starvation-inducible protein PhoH
WP8W19C03_09480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8W19C03_09490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8W19C03_09500	COG1335	isochorismatase
WP8W19C03_09510	COG1278	Cold shock
WP8W19C03_09520	COG3706	GGDEF domain
WP8W19C03_09530	COG0583	DNA-binding transcription factor activity
WP8W19C03_09570	COG5002	protein histidine kinase activity
WP8W19C03_09570	COG5001	Diguanylate cyclase
WP8W19C03_09570	COG3447	MASE1 domain protein
WP8W19C03_09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WP8W19C03_09610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WP8W19C03_09630	COG0516	GMP reductase activity
WP8W19C03_09650	COG0642	Histidine kinase
WP8W19C03_09680	COG4221	oxidoreductase activity
WP8W19C03_09730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_09760	COG3214	Protein conserved in bacteria
WP8W19C03_09780	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8W19C03_09790	COG0700	Nucleoside recognition
WP8W19C03_09800	COG3366	ferrous iron transmembrane transporter activity
WP8W19C03_09810	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8W19C03_09820	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
WP8W19C03_09830	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
WP8W19C03_09840	COG1053	succinate dehydrogenase
WP8W19C03_09860	COG0584	glycerophosphoryl diester phosphodiesterase
WP8W19C03_09870	COG1511	domain protein
WP8W19C03_09870	COG3264	Mechanosensitive ion channel
WP8W19C03_09890	COG0739	heme binding
WP8W19C03_09910	COG0583	DNA-binding transcription factor activity
WP8W19C03_09970	COG0583	DNA-binding transcription factor activity
WP8W19C03_09980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
WP8W19C03_10040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
WP8W19C03_10050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
WP8W19C03_10070	COG0338	D12 class N6 adenine-specific DNA methyltransferase
WP8W19C03_10080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WP8W19C03_10100	COG0180	Tryptophanyl-tRNA synthetase
WP8W19C03_10120	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8W19C03_10130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WP8W19C03_10150	COG1012	belongs to the aldehyde dehydrogenase family
WP8W19C03_10180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8W19C03_10190	COG2814	Major facilitator Superfamily
WP8W19C03_10210	COG2369	cell adhesion
WP8W19C03_10220	COG4383	Mu-like prophage protein gp29
WP8W19C03_10340	COG4396	Host-nuclease inhibitor protein Gam
WP8W19C03_10750	COG0477	Major facilitator Superfamily
WP8W19C03_10760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP8W19C03_10760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_10760	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP8W19C03_10760	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP8W19C03_10770	COG0366	Alpha amylase catalytic
WP8W19C03_10820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
WP8W19C03_10840	COG0490	domain, Protein
WP8W19C03_10840	COG0471	metal ion transport
WP8W19C03_10850	COG0012	GTP binding
WP8W19C03_10860	COG0193	aminoacyl-tRNA hydrolase activity
WP8W19C03_10870	COG0737	Belongs to the 5'-nucleotidase family
WP8W19C03_10880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WP8W19C03_10890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
WP8W19C03_10900	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WP8W19C03_10910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
WP8W19C03_10920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
WP8W19C03_10930	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8W19C03_10950	COG2912	Transglutaminase-like superfamily
WP8W19C03_10960	COG2877	3-deoxy-8-phosphooctulonate synthase activity
WP8W19C03_10970	COG1301	dicarboxylic acid transport
WP8W19C03_11000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WP8W19C03_11020	COG3408	Glycogen debranching enzyme
WP8W19C03_11020	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
WP8W19C03_11040	COG1881	PFAM PEBP family protein
WP8W19C03_11080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8W19C03_11100	COG0583	DNA-binding transcription factor activity
WP8W19C03_11110	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_11120	COG0616	signal peptide processing
WP8W19C03_11130	COG2211	Major facilitator Superfamily
WP8W19C03_11140	COG3706	GGDEF domain
WP8W19C03_11150	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8W19C03_11170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8W19C03_11190	COG2200	EAL domain
WP8W19C03_11190	COG2199	diguanylate cyclase activity
WP8W19C03_11190	COG2203	Gaf domain
WP8W19C03_11220	COG5433	transposase activity
WP8W19C03_11260	COG5433	transposase activity
WP8W19C03_11270	COG2197	response regulator
WP8W19C03_11300	COG3724	N-succinylarginine dihydrolase activity
WP8W19C03_11340	COG0840	transmembrane signaling receptor activity
WP8W19C03_11360	COG2971	BadF BadG BcrA BcrD
WP8W19C03_11380	COG4608	Belongs to the ABC transporter superfamily
WP8W19C03_11390	COG0444	Belongs to the ABC transporter superfamily
WP8W19C03_11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8W19C03_11430	COG0784	Response regulator, receiver
WP8W19C03_11430	COG2205	protein histidine kinase activity
WP8W19C03_11470	COG3220	belongs to the UPF0276 family
WP8W19C03_11530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8W19C03_11540	COG1289	transmembrane transporter activity
WP8W19C03_11550	COG0303	'Molybdopterin
WP8W19C03_11560	COG0746	molybdenum cofactor guanylyltransferase activity
WP8W19C03_11580	COG4662	Binding-protein-dependent transport system inner membrane component
WP8W19C03_11600	COG2204	response regulator
WP8W19C03_11610	COG3852	Histidine kinase
WP8W19C03_11630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WP8W19C03_11710	COG3383	formate dehydrogenase (NAD+) activity
WP8W19C03_11710	COG3383	formate dehydrogenase (NAD+) activity
WP8W19C03_11720	COG0437	4 iron, 4 sulfur cluster binding
WP8W19C03_11760	COG0281	malic enzyme
WP8W19C03_11800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_11860	COG0837	glucose binding
WP8W19C03_11870	COG1737	Transcriptional regulator
WP8W19C03_11880	COG0469	pyruvate kinase activity
WP8W19C03_11920	COG1677	Flagellar hook-basal body complex protein FliE
WP8W19C03_11940	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WP8W19C03_12040	COG1987	bacterial-type flagellum assembly
WP8W19C03_12050	COG1684	flagellar biosynthetic protein fliR
WP8W19C03_12070	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WP8W19C03_12120	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WP8W19C03_12130	COG0784	Response regulator, receiver
WP8W19C03_12130	COG2198	Histidine kinase
WP8W19C03_12130	COG0643	Histidine kinase
WP8W19C03_12140	COG2201	protein-glutamate methylesterase activity
WP8W19C03_12150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8W19C03_12160	COG1360	Flagellar Motor Protein
WP8W19C03_12170	COG1192	Involved in chromosome partitioning
WP8W19C03_12190	COG0835	chemotaxis
WP8W19C03_12220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8W19C03_12230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8W19C03_12240	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WP8W19C03_12250	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
WP8W19C03_12260	COG1138	Cytochrome C-type biogenesis protein
WP8W19C03_12270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8W19C03_12300	COG2853	Lipoprotein
WP8W19C03_12320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WP8W19C03_12340	COG3039	Transposase
WP8W19C03_12360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8W19C03_12370	COG1882	Formate acetyltransferase
WP8W19C03_12390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8W19C03_12390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8W19C03_12410	COG3039	Transposase
WP8W19C03_12430	COG0259	pyridoxamine-phosphate oxidase activity
WP8W19C03_12440	COG0625	glutathione transferase activity
WP8W19C03_12480	COG2850	peptidyl-arginine hydroxylation
WP8W19C03_12490	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
WP8W19C03_12500	COG2915	High frequency lysogenization protein hflD homolog
WP8W19C03_12510	COG0482	sulfurtransferase activity
WP8W19C03_12530	COG1187	pseudouridine synthase activity
WP8W19C03_12550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_12560	COG2271	Major facilitator Superfamily
WP8W19C03_12570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_12570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_12570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_12610	COG5433	transposase activity
WP8W19C03_12620	COG4821	SIS domain
WP8W19C03_12630	COG3385	transposase activity
WP8W19C03_12670	COG1609	Transcriptional regulator
WP8W19C03_12680	COG1263	PTS System
WP8W19C03_12680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_12690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
WP8W19C03_12710	COG5433	transposase activity
WP8W19C03_12740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WP8W19C03_12760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_12770	COG1960	acyl-CoA dehydrogenase activity
WP8W19C03_12790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
WP8W19C03_12810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_12810	COG2205	protein histidine kinase activity
WP8W19C03_12830	COG3039	Transposase
WP8W19C03_12840	COG0582	viral genome integration into host DNA
WP8W19C03_12850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
WP8W19C03_12860	COG2867	negative regulation of translational initiation
WP8W19C03_12870	COG2914	Belongs to the UPF0125 (RnfH) family
WP8W19C03_12880	COG1473	amidohydrolase
WP8W19C03_12890	COG1960	acyl-CoA dehydrogenase activity
WP8W19C03_12900	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WP8W19C03_12910	COG0121	glutamine amidotransferase
WP8W19C03_12970	COG2197	response regulator
WP8W19C03_12980	COG3850	Histidine kinase
WP8W19C03_12990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WP8W19C03_13000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8W19C03_13020	COG0243	molybdopterin cofactor binding
WP8W19C03_13030	COG0437	4 iron, 4 sulfur cluster binding
WP8W19C03_13040	COG0348	domain, Protein
WP8W19C03_13060	COG3005	denitrification pathway
WP8W19C03_13070	COG0521	Mo-molybdopterin cofactor biosynthetic process
WP8W19C03_13080	COG0315	cyclic pyranopterin monophosphate synthase activity
WP8W19C03_13090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WP8W19C03_13100	COG0314	molybdopterin synthase activity
WP8W19C03_13130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
WP8W19C03_13150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8W19C03_13170	COG0302	gtp cyclohydrolase
WP8W19C03_13180	COG0840	transmembrane signaling receptor activity
WP8W19C03_13190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
WP8W19C03_13210	COG0583	DNA-binding transcription factor activity
WP8W19C03_13220	COG2353	YceI-like domain
WP8W19C03_13240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
WP8W19C03_13270	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8W19C03_13280	COG1166	arginine decarboxylase activity
WP8W19C03_13320	COG0814	amino acid
WP8W19C03_13340	COG3681	Belongs to the UPF0597 family
WP8W19C03_13350	COG2964	Protein conserved in bacteria
WP8W19C03_13380	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
WP8W19C03_13390	COG1288	antiporter activity
WP8W19C03_13400	COG0436	Aminotransferase
WP8W19C03_13420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8W19C03_13430	COG0739	heme binding
WP8W19C03_13430	COG1196	nuclear chromosome segregation
WP8W19C03_13430	COG0741	lytic transglycosylase activity
WP8W19C03_13460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8W19C03_13480	COG0788	formyltetrahydrofolate deformylase activity
WP8W19C03_13490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8W19C03_13510	COG3118	belongs to the thioredoxin family
WP8W19C03_13530	COG0791	NLP P60 protein
WP8W19C03_13540	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
WP8W19C03_13560	COG0471	metal ion transport
WP8W19C03_13580	COG1388	LysM domain
WP8W19C03_13580	COG1376	ErfK ybiS ycfS ynhG family protein
WP8W19C03_13590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_13600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_13610	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_13620	COG5002	protein histidine kinase activity
WP8W19C03_13670	COG1388	LysM domain
WP8W19C03_13670	COG0741	lytic transglycosylase activity
WP8W19C03_13680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8W19C03_13690	COG2226	methyltransferase
WP8W19C03_13700	COG0328	RNA-DNA hybrid ribonuclease activity
WP8W19C03_13710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8W19C03_13730	COG5433	transposase activity
WP8W19C03_13740	COG3437	response regulator, receiver
WP8W19C03_13740	COG0784	Response regulator, receiver
WP8W19C03_13750	COG2375	cellular response to nickel ion
WP8W19C03_13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8W19C03_13770	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8W19C03_13780	COG1120	ATPase activity
WP8W19C03_13810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_13890	COG0708	Exodeoxyribonuclease III
WP8W19C03_13950	COG3132	Protein of unknown function, DUF480
WP8W19C03_13960	COG3300	MHYT domain
WP8W19C03_13960	COG5001	Diguanylate cyclase
WP8W19C03_13980	COG2841	Protein conserved in bacteria
WP8W19C03_14000	COG0534	Mate efflux family protein
WP8W19C03_14070	COG1309	transcriptional regulator
WP8W19C03_14150	COG3152	Membrane
WP8W19C03_14180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_14190	COG3537	Alpha-1,2-mannosidase
WP8W19C03_14200	COG5433	transposase activity
WP8W19C03_14230	COG3537	Alpha-1,2-mannosidase
WP8W19C03_14250	COG2207	Transcriptional regulator
WP8W19C03_14270	COG2207	Transcriptional regulator
WP8W19C03_14280	COG0538	isocitrate dehydrogenase activity
WP8W19C03_14300	COG3048	D-serine ammonia-lyase activity
WP8W19C03_14310	COG2610	gluconate transmembrane transporter activity
WP8W19C03_14320	COG0583	DNA-binding transcription factor activity
WP8W19C03_14340	COG0791	NLP P60 protein
WP8W19C03_14350	COG0583	DNA-binding transcription factor activity
WP8W19C03_14360	COG0450	alkyl hydroperoxide reductase
WP8W19C03_14400	COG0500	methyltransferase
WP8W19C03_14410	COG4106	trans-aconitate 2-methyltransferase activity
WP8W19C03_14420	COG1801	Protein of unknown function DUF72
WP8W19C03_14440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WP8W19C03_14450	COG0217	transcriptional regulatory protein
WP8W19C03_14460	COG1012	belongs to the aldehyde dehydrogenase family
WP8W19C03_14460	COG1454	alcohol dehydrogenase
WP8W19C03_14470	COG2095	MarC family integral membrane protein
WP8W19C03_14490	COG0601	transmembrane transport
WP8W19C03_14500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WP8W19C03_14530	COG0861	Integral membrane protein TerC family
WP8W19C03_14540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
WP8W19C03_14610	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
WP8W19C03_14620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8W19C03_14630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
WP8W19C03_14640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8W19C03_14650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WP8W19C03_14660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WP8W19C03_14700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
WP8W19C03_14710	COG0505	Belongs to the CarA family
WP8W19C03_14720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WP8W19C03_14740	COG0287	Prephenate dehydrogenase
WP8W19C03_14740	COG1605	Chorismate mutase
WP8W19C03_14750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8W19C03_14770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8W19C03_14780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8W19C03_14850	COG0537	adenosine 5'-monophosphoramidase activity
WP8W19C03_14880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WP8W19C03_14900	COG1301	dicarboxylic acid transport
WP8W19C03_14930	COG2354	Protein conserved in bacteria
WP8W19C03_14950	COG2233	PERMEase
WP8W19C03_14960	COG3150	esterase
WP8W19C03_14970	COG1252	NADH dehydrogenase
WP8W19C03_14990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8W19C03_15000	COG3300	MHYT domain
WP8W19C03_15000	COG5001	Diguanylate cyclase
WP8W19C03_15010	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8W19C03_15030	COG2373	Large extracellular alpha-helical protein
WP8W19C03_15040	COG4953	penicillin-binding protein 1C
WP8W19C03_15060	COG0301	tRNA thio-modification
WP8W19C03_15060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8W19C03_15100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8W19C03_15160	COG2089	acid synthase
WP8W19C03_15180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
WP8W19C03_15200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP8W19C03_15210	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP8W19C03_15230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WP8W19C03_15240	COG1086	Polysaccharide biosynthesis protein
WP8W19C03_15250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8W19C03_15270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WP8W19C03_15290	COG0483	inositol monophosphate 1-phosphatase activity
WP8W19C03_15310	COG0625	glutathione transferase activity
WP8W19C03_15320	COG2814	Major facilitator Superfamily
WP8W19C03_15350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8W19C03_15360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WP8W19C03_15370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
WP8W19C03_15380	COG0509	glycine decarboxylation via glycine cleavage system
WP8W19C03_15390	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8W19C03_15390	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WP8W19C03_15430	COG3012	SEC-C Motif Domain Protein
WP8W19C03_15430	COG3318	Belongs to the UPF0149 family
WP8W19C03_15440	COG0714	Associated with various cellular activities
WP8W19C03_15460	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP8W19C03_15540	COG5642	Protein of unknown function (DUF2384)
WP8W19C03_15550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WP8W19C03_15570	COG3039	Transposase
WP8W19C03_15590	COG0840	transmembrane signaling receptor activity
WP8W19C03_15650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WP8W19C03_15660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WP8W19C03_15660	COG0574	Belongs to the PEP-utilizing enzyme family
WP8W19C03_15690	COG1464	Belongs to the NlpA lipoprotein family
WP8W19C03_15700	COG3083	sulfuric ester hydrolase activity
WP8W19C03_15710	COG3082	Protein of unknown function (DUF1414)
WP8W19C03_15720	COG3081	Nucleoid-associated protein
WP8W19C03_15740	COG1175	transmembrane transport
WP8W19C03_15750	COG3833	ABC-type maltose transport systems, permease component
WP8W19C03_15760	COG3842	ATPase activity
WP8W19C03_15810	COG0425	Belongs to the sulfur carrier protein TusA family
WP8W19C03_15820	COG4783	chaperone-mediated protein folding
WP8W19C03_15830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WP8W19C03_15840	COG1393	Belongs to the ArsC family
WP8W19C03_15860	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
WP8W19C03_15870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_15880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8W19C03_15890	COG2431	L-lysine efflux transmembrane transporter activity
WP8W19C03_15910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_15930	COG4160	amino acid transport
WP8W19C03_15940	COG0564	pseudouridine synthase activity
WP8W19C03_15970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WP8W19C03_15990	COG0625	glutathione transferase activity
WP8W19C03_16040	COG0642	Histidine kinase
WP8W19C03_16050	COG2261	transglycosylase associated protein
WP8W19C03_16080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8W19C03_16100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8W19C03_16110	COG0215	cysteine-tRNA ligase activity
WP8W19C03_16120	COG1106	Psort location Cytoplasmic, score
WP8W19C03_16190	COG2119	membrane
WP8W19C03_16200	COG0023	Translation Initiation Factor
WP8W19C03_16250	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_16270	COG0493	'glutamate synthase
WP8W19C03_16280	COG0070	glutamate synthase
WP8W19C03_16280	COG0069	glutamate synthase activity
WP8W19C03_16280	COG0067	glutamate synthase
WP8W19C03_16290	COG1242	4 iron, 4 sulfur cluster binding
WP8W19C03_16400	COG3634	alkyl hydroperoxide reductase activity
WP8W19C03_16420	COG0517	IMP dehydrogenase activity
WP8W19C03_16430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
WP8W19C03_16440	COG0343	queuine tRNA-ribosyltransferase activity
WP8W19C03_16450	COG1862	Preprotein translocase
WP8W19C03_16460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8W19C03_16470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WP8W19C03_16500	COG0826	peptidase U32
WP8W19C03_16510	COG0826	peptidase U32
WP8W19C03_16520	COG3154	lipid carrier protein
WP8W19C03_16560	COG1104	cysteine desulfurase activity
WP8W19C03_16570	COG0822	iron-sulfur transferase activity
WP8W19C03_16590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8W19C03_16600	COG0443	Heat shock 70 kDa protein
WP8W19C03_16610	COG0633	Ferredoxin
WP8W19C03_16640	COG0105	UTP biosynthetic process
WP8W19C03_16650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WP8W19C03_16690	COG0124	histidyl-tRNA synthetase
WP8W19C03_16700	COG2976	Protein conserved in bacteria
WP8W19C03_16710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8W19C03_16720	COG1160	GTP binding
WP8W19C03_16730	COG1645	bacterial-type flagellum-dependent swarming motility
WP8W19C03_16750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8W19C03_16760	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WP8W19C03_16760	COG0047	phosphoribosylformylglycinamidine synthase activity
WP8W19C03_16770	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8W19C03_16770	COG2199	diguanylate cyclase activity
WP8W19C03_16800	COG1007	ATP synthesis coupled electron transport
WP8W19C03_16810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_16830	COG0713	ATP synthesis coupled electron transport
WP8W19C03_16840	COG0839	Belongs to the complex I subunit 6 family
WP8W19C03_16850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_16860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WP8W19C03_16870	COG1034	ATP synthesis coupled electron transport
WP8W19C03_16900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_16900	COG0649	NAD binding
WP8W19C03_16910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_16920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WP8W19C03_16960	COG1770	oligopeptidase
WP8W19C03_16970	COG4771	TonB-dependent receptor
WP8W19C03_16980	COG1360	Flagellar Motor Protein
WP8W19C03_16990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8W19C03_17050	COG5642	Protein of unknown function (DUF2384)
WP8W19C03_17080	COG3039	Transposase
WP8W19C03_17170	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
WP8W19C03_17190	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
WP8W19C03_17200	COG4597	amino acid ABC transporter
WP8W19C03_17210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_17220	COG0765	amino acid transport
WP8W19C03_17230	COG1126	abc transporter atp-binding protein
WP8W19C03_17250	COG0724	RNA recognition motif
WP8W19C03_17260	COG4989	oxidoreductase activity
WP8W19C03_17310	COG3437	response regulator, receiver
WP8W19C03_17320	COG0583	DNA-binding transcription factor activity
WP8W19C03_17330	COG3039	Transposase
WP8W19C03_17340	COG5001	Diguanylate cyclase
WP8W19C03_17340	COG3300	MHYT domain
WP8W19C03_17350	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
WP8W19C03_17370	COG3385	transposase activity
WP8W19C03_17410	COG2814	Major facilitator Superfamily
WP8W19C03_17440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
WP8W19C03_17450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WP8W19C03_17460	COG0539	negative regulation of cytoplasmic translation
WP8W19C03_17470	COG0776	regulation of translation
WP8W19C03_17490	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WP8W19C03_17530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WP8W19C03_17540	COG0602	queuosine metabolic process
WP8W19C03_17550	COG3530	Putative quorum-sensing-regulated virulence factor
WP8W19C03_17560	COG2096	Adenosyltransferase
WP8W19C03_17570	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8W19C03_17580	COG1757	Na H antiporter
WP8W19C03_17590	COG1435	thymidine kinase activity
WP8W19C03_17690	COG5433	transposase activity
WP8W19C03_17710	COG3039	Transposase
WP8W19C03_17740	COG3039	Transposase
WP8W19C03_17750	COG0583	DNA-binding transcription factor activity
WP8W19C03_17790	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
WP8W19C03_17800	COG0326	Molecular chaperone. Has ATPase activity
WP8W19C03_17810	COG4172	Belongs to the ABC transporter superfamily
WP8W19C03_17820	COG4172	Belongs to the ABC transporter superfamily
WP8W19C03_17840	COG4168	peptide transport system, permease
WP8W19C03_17860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
WP8W19C03_17870	COG1842	Phage shock protein A
WP8W19C03_17900	COG3106	COG3106 Predicted ATPase
WP8W19C03_17910	COG3768	UPF0283 membrane protein
WP8W19C03_17920	COG0583	DNA-binding transcription factor activity
WP8W19C03_17930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WP8W19C03_17940	COG3842	ATPase activity
WP8W19C03_17950	COG1176	ABC-type spermidine putrescine transport system, permease component I
WP8W19C03_17960	COG1177	transmembrane transport
WP8W19C03_17970	COG1012	belongs to the aldehyde dehydrogenase family
WP8W19C03_17990	COG2154	pterin-4-alpha-carbinolamine dehydratase
WP8W19C03_18030	COG2199	diguanylate cyclase activity
WP8W19C03_18040	COG2885	chlorophyll binding
WP8W19C03_18050	COG0861	Integral membrane protein TerC family
WP8W19C03_18110	COG2910	NAD(P)H-binding
WP8W19C03_18120	COG0583	DNA-binding transcription factor activity
WP8W19C03_18130	COG0583	DNA-binding transcription factor activity
WP8W19C03_18140	COG2271	Major facilitator Superfamily
WP8W19C03_18160	COG1335	isochorismatase
WP8W19C03_18180	COG0583	DNA-binding transcription factor activity
WP8W19C03_18190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
WP8W19C03_18210	COG0583	DNA-binding transcription factor activity
WP8W19C03_18220	COG2723	6-phospho-beta-galactosidase activity
WP8W19C03_18240	COG0583	DNA-binding transcription factor activity
WP8W19C03_18250	COG1944	ATP diphosphatase activity
WP8W19C03_18260	COG2116	formate transmembrane transporter activity
WP8W19C03_18270	COG1882	Formate acetyltransferase
WP8W19C03_18280	COG2983	Belongs to the UPF0260 family
WP8W19C03_18310	COG0058	SHG alpha-glucan phosphorylase activity
WP8W19C03_18320	COG0471	metal ion transport
WP8W19C03_18330	COG3118	belongs to the thioredoxin family
WP8W19C03_18350	COG1132	(ABC) transporter
WP8W19C03_18360	COG1132	(ABC) transporter
WP8W19C03_18380	COG2501	S4 domain
WP8W19C03_18410	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8W19C03_18470	COG0456	acetyltransferase
WP8W19C03_18500	COG2009	succinate dehydrogenase
WP8W19C03_18510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
WP8W19C03_18520	COG1053	succinate dehydrogenase
WP8W19C03_18540	COG0567	Dehydrogenase, E1 component
WP8W19C03_18550	COG0508	dehydrogenase complex catalyzes the overall conversion of
WP8W19C03_18560	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8W19C03_18590	COG1584	GPR1 FUN34 yaaH family protein
WP8W19C03_18650	COG1024	Enoyl-CoA hydratase
WP8W19C03_18660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
WP8W19C03_18670	COG1960	acyl-CoA dehydrogenase activity
WP8W19C03_18680	COG1960	acyl-CoA dehydrogenase activity
WP8W19C03_18690	COG1024	Enoyl-CoA hydratase
WP8W19C03_18700	COG1024	Enoyl-CoA hydratase
WP8W19C03_18720	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_18740	COG0730	response to heat
WP8W19C03_18850	COG2003	Belongs to the UPF0758 family
WP8W19C03_18890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8W19C03_18940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8W19C03_18950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_18960	COG3046	protein related to deoxyribodipyrimidine photolyase
WP8W19C03_18970	COG3033	Beta-eliminating lyase
WP8W19C03_18980	COG0295	cytidine deaminase activity
WP8W19C03_18990	COG1346	cytolysis
WP8W19C03_19000	COG1380	Effector of murein hydrolase LrgA
WP8W19C03_19010	COG3345	alpha-galactosidase
WP8W19C03_19030	COG2925	Exonuclease
WP8W19C03_19180	COG0641	radical SAM
WP8W19C03_19230	COG2304	oxidoreductase activity
WP8W19C03_19270	COG0714	Associated with various cellular activities
WP8W19C03_19280	COG0714	Associated with various cellular activities
WP8W19C03_19290	COG3119	arylsulfatase activity
WP8W19C03_19300	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8W19C03_19310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
WP8W19C03_19310	COG0517	IMP dehydrogenase activity
WP8W19C03_19310	COG0617	tRNA 3'-terminal CCA addition
WP8W19C03_19320	COG1643	Atp-dependent helicase
WP8W19C03_19340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
WP8W19C03_19370	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
WP8W19C03_19380	COG2067	long-chain fatty acid transport protein
WP8W19C03_19390	COG2067	long-chain fatty acid transport protein
WP8W19C03_19410	COG1595	DNA-templated transcription, initiation
WP8W19C03_19430	COG2304	oxidoreductase activity
WP8W19C03_19470	COG0714	Associated with various cellular activities
WP8W19C03_19480	COG0183	Belongs to the thiolase family
WP8W19C03_19490	COG1024	Enoyl-CoA hydratase
WP8W19C03_19490	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8W19C03_19500	COG2719	SpoVR family
WP8W19C03_19510	COG2718	Belongs to the UPF0229 family
WP8W19C03_19520	COG2766	serine protein kinase
WP8W19C03_19530	COG0514	ATP-dependent DNA helicase (RecQ)
WP8W19C03_19540	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
WP8W19C03_19560	COG0814	amino acid
WP8W19C03_19570	COG0494	nUDIX hydrolase
WP8W19C03_19600	COG2824	Alkylphosphonate utilization operon protein PhnA
WP8W19C03_19650	COG3706	GGDEF domain
WP8W19C03_19660	COG2840	Smr protein MutS2
WP8W19C03_19670	COG2890	protein-(glutamine-N5) methyltransferase activity
WP8W19C03_19680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
WP8W19C03_19700	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_19720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
WP8W19C03_19740	COG0814	amino acid
WP8W19C03_19750	COG1609	Transcriptional regulator
WP8W19C03_19760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_19760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_19770	COG1105	Belongs to the carbohydrate kinase PfkB family
WP8W19C03_19780	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
WP8W19C03_19780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_19780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_19790	COG1530	ribonuclease E activity
WP8W19C03_19820	COG0424	maF-like protein
WP8W19C03_19830	COG1399	metal-binding, possibly nucleic acid-binding protein
WP8W19C03_19840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
WP8W19C03_19850	COG0416	fatty acid biosynthetic process
WP8W19C03_19860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
WP8W19C03_19880	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_19890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
WP8W19C03_19900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8W19C03_19910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
WP8W19C03_19920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WP8W19C03_19930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
WP8W19C03_19940	COG0470	DNA polymerase III
WP8W19C03_19950	COG0084	hydrolase, TatD family'
WP8W19C03_19980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8W19C03_19980	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
WP8W19C03_19990	COG3008	intermembrane lipid transfer
WP8W19C03_20000	COG2995	paraquat-inducible protein a
WP8W19C03_20020	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
WP8W19C03_20030	COG0372	Belongs to the citrate synthase family
WP8W19C03_20120	COG4221	oxidoreductase activity
WP8W19C03_20130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
WP8W19C03_20140	COG3141	response to X-ray
WP8W19C03_20180	COG1067	ATP-dependent peptidase activity
WP8W19C03_20190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8W19C03_20230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8W19C03_20230	COG0116	Belongs to the methyltransferase superfamily
WP8W19C03_20240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
WP8W19C03_20250	COG0254	rRNA binding
WP8W19C03_20280	COG0167	dihydroorotate dehydrogenase activity
WP8W19C03_20290	COG2902	Dehydrogenase
WP8W19C03_20310	COG0308	aminopeptidase N
WP8W19C03_20330	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
WP8W19C03_20340	COG1956	GAF domain-containing protein
WP8W19C03_20360	COG3278	Belongs to the heme-copper respiratory oxidase family
WP8W19C03_20390	COG2010	Cytochrome c
WP8W19C03_20410	COG2217	Heavy metal translocating P-type atpase
WP8W19C03_20440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
WP8W19C03_20450	COG0589	response to stress
WP8W19C03_20460	COG0037	tRNA processing
WP8W19C03_20510	COG1177	transmembrane transport
WP8W19C03_20560	COG1869	D-ribose catabolic process
WP8W19C03_20570	COG1129	ABC transporter
WP8W19C03_20580	COG1172	Belongs to the binding-protein-dependent transport system permease family
WP8W19C03_20590	COG1879	ABC-type sugar transport system periplasmic component
WP8W19C03_20600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8W19C03_20610	COG1609	Transcriptional regulator
WP8W19C03_20620	COG3706	GGDEF domain
WP8W19C03_20670	COG2205	protein histidine kinase activity
WP8W19C03_20670	COG0784	Response regulator, receiver
WP8W19C03_20680	COG0776	regulation of translation
WP8W19C03_20690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8W19C03_20690	COG0072	phenylalanine-tRNA ligase activity
WP8W19C03_20700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WP8W19C03_20710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
WP8W19C03_20720	COG0291	Belongs to the bacterial ribosomal protein bL35 family
WP8W19C03_20730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WP8W19C03_20740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WP8W19C03_20780	COG0366	Alpha amylase catalytic
WP8W19C03_20800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8W19C03_20820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8W19C03_20830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8W19C03_20840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8W19C03_20850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WP8W19C03_20860	COG3313	Fe-S protein
WP8W19C03_20870	COG2942	2-epimerase
WP8W19C03_20880	COG3716	PTS system mannose fructose sorbose family IID component
WP8W19C03_20890	COG3715	PTS system
WP8W19C03_20900	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_20900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_20930	COG1609	Transcriptional regulator
WP8W19C03_20940	COG2140	Oxalate decarboxylase
WP8W19C03_20950	COG0306	phosphate transporter
WP8W19C03_20960	COG0717	Belongs to the dCTP deaminase family
WP8W19C03_20970	COG0572	uridine kinase
WP8W19C03_20980	COG0489	protein tyrosine kinase activity
WP8W19C03_20990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8W19C03_20990	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8W19C03_21010	COG1254	Belongs to the acylphosphatase family
WP8W19C03_21030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8W19C03_21040	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WP8W19C03_21070	COG0709	Synthesizes selenophosphate from selenide and ATP
WP8W19C03_21080	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WP8W19C03_21090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WP8W19C03_21110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WP8W19C03_21130	COG0318	PFAM AMP-dependent synthetase and ligase
WP8W19C03_21140	COG2267	carboxylic ester hydrolase activity
WP8W19C03_21160	COG1214	PFAM Peptidase M22, glycoprotease
WP8W19C03_21170	COG1199	ATP-dependent helicase activity
WP8W19C03_21190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
WP8W19C03_21200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WP8W19C03_21210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
WP8W19C03_21220	COG0131	Imidazoleglycerol-phosphate dehydratase
WP8W19C03_21220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8W19C03_21230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
WP8W19C03_21240	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
WP8W19C03_21250	COG0107	imidazoleglycerol-phosphate synthase activity
WP8W19C03_21280	COG3706	GGDEF domain
WP8W19C03_21290	COG0318	PFAM AMP-dependent synthetase and ligase
WP8W19C03_21300	COG1288	antiporter activity
WP8W19C03_21320	COG3134	Outer membrane lipoprotein
WP8W19C03_21330	COG2080	2 iron, 2 sulfur cluster binding
WP8W19C03_21340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP8W19C03_21350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP8W19C03_21360	COG2252	PERMEase
WP8W19C03_21370	COG0402	S-adenosylhomocysteine deaminase activity
WP8W19C03_21380	COG2233	PERMEase
WP8W19C03_21390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WP8W19C03_21390	COG2080	2 iron, 2 sulfur cluster binding
WP8W19C03_21400	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WP8W19C03_21410	COG0402	S-adenosylhomocysteine deaminase activity
WP8W19C03_21420	COG0493	'glutamate synthase
WP8W19C03_21420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WP8W19C03_21430	COG2068	MobA-Related Protein
WP8W19C03_21440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WP8W19C03_21450	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
WP8W19C03_21450	COG3608	succinylglutamate desuccinylase aspartoacylase
WP8W19C03_21460	COG0697	spore germination
WP8W19C03_21480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
WP8W19C03_21510	COG0549	Belongs to the carbamate kinase family
WP8W19C03_21530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8W19C03_21540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WP8W19C03_21550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8W19C03_21620	COG0242	peptide deformylase activity
WP8W19C03_21650	COG5433	transposase activity
WP8W19C03_21670	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
WP8W19C03_21680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WP8W19C03_21690	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
WP8W19C03_21710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
WP8W19C03_21720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
WP8W19C03_21740	COG0205	6-phosphofructokinase activity
WP8W19C03_21760	COG3123	guanosine phosphorylase activity
WP8W19C03_21770	COG1760	l-serine dehydratase
WP8W19C03_21780	COG1760	l-serine dehydratase
WP8W19C03_21790	COG3100	YcgL domain-containing protein
WP8W19C03_21800	COG0850	regulation of cytokinetic process
WP8W19C03_21810	COG2894	cell division
WP8W19C03_21820	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WP8W19C03_21830	COG3099	Belongs to the UPF0263 family
WP8W19C03_21840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WP8W19C03_21920	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
WP8W19C03_21930	COG0697	spore germination
WP8W19C03_21940	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WP8W19C03_21950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8W19C03_21970	COG0307	riboflavin synthase, alpha
WP8W19C03_22000	COG0534	Mate efflux family protein
WP8W19C03_22040	COG4681	YaeQ
WP8W19C03_22070	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8W19C03_22080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WP8W19C03_22090	COG0586	Pfam SNARE associated Golgi protein
WP8W19C03_22110	COG0556	nucleotide-excision repair
WP8W19C03_22120	COG2985	domain, Protein
WP8W19C03_22120	COG0569	domain protein
WP8W19C03_22130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WP8W19C03_22140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WP8W19C03_22140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_22170	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8W19C03_22200	COG1451	nucleotide metabolic process
WP8W19C03_22230	COG0417	DNA replication proofreading
WP8W19C03_22250	COG2203	Gaf domain
WP8W19C03_22250	COG2199	diguanylate cyclase activity
WP8W19C03_22280	COG1560	Kdo2-lipid A biosynthetic process
WP8W19C03_22300	COG1560	Kdo2-lipid A biosynthetic process
WP8W19C03_22330	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
WP8W19C03_22340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WP8W19C03_22350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WP8W19C03_22360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
WP8W19C03_22370	COG2832	Protein of unknown function (DUF454)
WP8W19C03_22380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8W19C03_22410	COG1011	Hydrolase
WP8W19C03_22420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
WP8W19C03_22450	COG3593	DNA synthesis involved in DNA repair
WP8W19C03_22480	COG0583	DNA-binding transcription factor activity
WP8W19C03_22490	COG0730	response to heat
WP8W19C03_22510	COG1940	carbohydrate kinase activity
WP8W19C03_22510	COG1846	Transcriptional regulator
WP8W19C03_22520	COG0840	transmembrane signaling receptor activity
WP8W19C03_22530	COG3012	SEC-C Motif Domain Protein
WP8W19C03_22540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
WP8W19C03_22550	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
WP8W19C03_22560	COG0247	lactate metabolic process
WP8W19C03_22600	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
WP8W19C03_22610	COG0437	4 iron, 4 sulfur cluster binding
WP8W19C03_22620	COG3301	Polysulphide reductase, NrfD
WP8W19C03_22630	COG1138	Cytochrome C-type biogenesis protein
WP8W19C03_22650	COG3088	subunit of a heme lyase
WP8W19C03_22650	COG4235	cytochrome complex assembly
WP8W19C03_22680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WP8W19C03_22700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WP8W19C03_22720	COG1840	ABC-type Fe3 transport system, periplasmic component
WP8W19C03_22730	COG3842	ATPase activity
WP8W19C03_22750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_22790	COG2801	Transposase and inactivated derivatives
WP8W19C03_22820	COG1115	amino acid carrier protein
WP8W19C03_22880	COG4695	Portal protein
WP8W19C03_22890	COG1024	Enoyl-CoA hydratase
WP8W19C03_22920	COG3162	membrane
WP8W19C03_22930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WP8W19C03_22940	COG0488	(ABC) transporter
WP8W19C03_22950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8W19C03_22960	COG0776	regulation of translation
WP8W19C03_22970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WP8W19C03_22980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
WP8W19C03_22990	COG0740	serine-type endopeptidase activity
WP8W19C03_23000	COG0544	peptidyl-prolyl cis-trans isomerase activity
WP8W19C03_23020	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
WP8W19C03_23030	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8W19C03_23040	COG1136	(ABC) transporter
WP8W19C03_23050	COG4591	ABC-type transport system involved in lipoprotein release permease component
WP8W19C03_23070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WP8W19C03_23080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WP8W19C03_23090	COG4166	transmembrane transport
WP8W19C03_23100	COG0697	spore germination
WP8W19C03_23110	COG3328	transposase activity
WP8W19C03_23130	COG2062	phosphohistidine phosphatase, SixA
WP8W19C03_23140	COG1025	Belongs to the peptidase M16 family
WP8W19C03_23190	COG5290	Psort location Cytoplasmic, score
WP8W19C03_23200	COG5433	transposase activity
WP8W19C03_23210	COG5290	Psort location Cytoplasmic, score
WP8W19C03_23230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8W19C03_23230	COG0519	Catalyzes the synthesis of GMP from XMP
WP8W19C03_23240	COG0516	GMP reductase activity
WP8W19C03_23240	COG0517	IMP dehydrogenase activity
WP8W19C03_23250	COG3038	cytochrome b561
WP8W19C03_23260	COG1570	exodeoxyribonuclease VII activity
WP8W19C03_23270	COG2188	Transcriptional regulator
WP8W19C03_23280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_23280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_23280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
WP8W19C03_23290	COG0383	alpha-mannosidase activity
WP8W19C03_23300	COG1181	Belongs to the D-alanine--D-alanine ligase family
WP8W19C03_23320	COG0386	Belongs to the glutathione peroxidase family
WP8W19C03_23330	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_23360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8W19C03_23370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
WP8W19C03_23380	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
WP8W19C03_23480	COG3300	MHYT domain
WP8W19C03_23480	COG5001	Diguanylate cyclase
WP8W19C03_23510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8W19C03_23530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WP8W19C03_23540	COG0563	adenylate kinase activity
WP8W19C03_23560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
WP8W19C03_23570	COG1286	toxin biosynthetic process
WP8W19C03_23580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
WP8W19C03_23600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WP8W19C03_23610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WP8W19C03_23620	COG0531	amino acid
WP8W19C03_23620	COG1674	ftsk spoiiie
WP8W19C03_23640	COG0686	Belongs to the AlaDH PNT family
WP8W19C03_23650	COG0492	ferredoxin-NADP+ reductase activity
WP8W19C03_23660	COG3706	GGDEF domain
WP8W19C03_23670	COG3134	Outer membrane lipoprotein
WP8W19C03_23680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
WP8W19C03_23690	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WP8W19C03_23700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
WP8W19C03_23710	COG0542	response to heat
WP8W19C03_23720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
WP8W19C03_23730	COG1278	Cold shock
WP8W19C03_23740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
WP8W19C03_23750	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_23760	COG2205	protein histidine kinase activity
WP8W19C03_23780	COG0392	lysyltransferase activity
WP8W19C03_23780	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
WP8W19C03_23800	COG0659	secondary active sulfate transmembrane transporter activity
WP8W19C03_23850	COG0672	)-iron permease
WP8W19C03_23890	COG2814	Major facilitator Superfamily
WP8W19C03_23920	COG1136	(ABC) transporter
WP8W19C03_23960	COG0596	Alpha beta hydrolase
WP8W19C03_24000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8W19C03_24010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WP8W19C03_24010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WP8W19C03_24020	COG0527	aspartate kinase activity
WP8W19C03_24040	COG1368	sulfuric ester hydrolase activity
WP8W19C03_24050	COG1619	proteins homologs of microcin C7 resistance protein MccF
WP8W19C03_24060	COG4667	esterase of the alpha-beta hydrolase superfamily
WP8W19C03_24100	COG1648	precorrin-2 dehydrogenase activity
WP8W19C03_24100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WP8W19C03_24120	COG0393	Putative heavy-metal-binding
WP8W19C03_24130	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
WP8W19C03_24140	COG0285	dihydrofolate synthase activity
WP8W19C03_24150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
WP8W19C03_24160	COG0101	tRNA pseudouridine synthase activity
WP8W19C03_24180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
WP8W19C03_24190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WP8W19C03_24200	COG0671	phosphoesterase, PA-phosphatase related
WP8W19C03_24210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WP8W19C03_24220	COG2056	Na+-H+ antiporter family
WP8W19C03_24230	COG5001	Diguanylate cyclase
WP8W19C03_24230	COG3300	MHYT domain
WP8W19C03_24260	COG2050	protein possibly involved in aromatic compounds catabolism
WP8W19C03_24280	COG0277	FAD linked oxidase domain protein
WP8W19C03_24280	COG0247	lactate metabolic process
WP8W19C03_24300	COG1253	flavin adenine dinucleotide binding
WP8W19C03_24310	COG1902	pentaerythritol trinitrate reductase activity
WP8W19C03_24320	COG0604	alcohol dehydrogenase
WP8W19C03_24320	COG3321	synthase
WP8W19C03_24320	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_24340	COG0647	UMP catabolic process
WP8W19C03_24350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
WP8W19C03_24350	COG4651	solute:proton antiporter activity
WP8W19C03_24370	COG0367	asparagine synthase
WP8W19C03_24410	COG0322	excinuclease ABC activity
WP8W19C03_24420	COG2197	response regulator
WP8W19C03_24430	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
WP8W19C03_24440	COG2835	tetraacyldisaccharide 4'-kinase activity
WP8W19C03_24450	COG1663	tetraacyldisaccharide 4'-kinase activity
WP8W19C03_24470	COG0658	competence protein
WP8W19C03_24470	COG2333	competence protein COMEC
WP8W19C03_24500	COG1448	Aminotransferase
WP8W19C03_24520	COG0583	DNA-binding transcription factor activity
WP8W19C03_24530	COG3085	chromosome segregation
WP8W19C03_24540	COG4574	serine-type endopeptidase inhibitor activity
WP8W19C03_24550	COG0584	glycerophosphoryl diester phosphodiesterase
WP8W19C03_24580	COG1349	DNA-binding transcription factor activity
WP8W19C03_24590	COG2271	Major facilitator Superfamily
WP8W19C03_24610	COG2271	Major facilitator Superfamily
WP8W19C03_24620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WP8W19C03_24630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WP8W19C03_24640	COG0840	transmembrane signaling receptor activity
WP8W19C03_24660	COG0583	DNA-binding transcription factor activity
WP8W19C03_24690	COG0656	L-ascorbic acid biosynthetic process
WP8W19C03_24710	COG2814	Major facilitator Superfamily
WP8W19C03_24720	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8W19C03_24750	COG3220	belongs to the UPF0276 family
WP8W19C03_24790	COG1294	oxidase, subunit
WP8W19C03_24810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WP8W19C03_24830	COG2979	Protein of unknown function (DUF533)
WP8W19C03_24860	COG0583	DNA-binding transcription factor activity
WP8W19C03_24870	COG2807	transmembrane transport
WP8W19C03_24880	COG1187	pseudouridine synthase activity
WP8W19C03_24910	COG0346	lactoylglutathione lyase activity
WP8W19C03_24930	COG1061	Type III restriction enzyme res subunit
WP8W19C03_24940	COG4657	Part of a membrane complex involved in electron transport
WP8W19C03_24950	COG2878	Part of a membrane complex involved in electron transport
WP8W19C03_24970	COG4658	electron transport chain
WP8W19C03_24980	COG4659	FMN binding
WP8W19C03_24990	COG4660	Part of a membrane complex involved in electron transport
WP8W19C03_25000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WP8W19C03_25010	COG0346	lactoylglutathione lyase activity
WP8W19C03_25060	COG2801	Transposase and inactivated derivatives
WP8W19C03_25080	COG5433	transposase activity
WP8W19C03_25100	COG1199	ATP-dependent helicase activity
WP8W19C03_25120	COG0123	including yeast histone deacetylase and acetoin utilization protein
WP8W19C03_25130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
WP8W19C03_25140	COG1785	Belongs to the alkaline phosphatase family
WP8W19C03_25180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WP8W19C03_25190	COG2197	response regulator
WP8W19C03_25210	COG2271	Major facilitator Superfamily
WP8W19C03_25220	COG3706	GGDEF domain
WP8W19C03_25230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_25240	COG0765	amino acid transport
WP8W19C03_25250	COG1126	abc transporter atp-binding protein
WP8W19C03_25280	COG0531	amino acid
WP8W19C03_25310	COG1253	flavin adenine dinucleotide binding
WP8W19C03_25320	COG0704	Plays a role in the regulation of phosphate uptake
WP8W19C03_25340	COG0581	inorganic phosphate transmembrane transporter activity
WP8W19C03_25350	COG0573	inorganic phosphate transmembrane transporter activity
WP8W19C03_25360	COG0590	tRNA wobble adenosine to inosine editing
WP8W19C03_25380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WP8W19C03_25420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WP8W19C03_25430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WP8W19C03_25440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WP8W19C03_25450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WP8W19C03_25470	COG3852	Histidine kinase
WP8W19C03_25500	COG2716	regulation of RNA biosynthetic process
WP8W19C03_25510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
WP8W19C03_25530	COG2239	Acts as a magnesium transporter
WP8W19C03_25540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
WP8W19C03_25570	COG1706	bacterial-type flagellum-dependent cell motility
WP8W19C03_25580	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
WP8W19C03_25600	COG4787	bacterial-type flagellum-dependent cell motility
WP8W19C03_25640	COG1815	bacterial-type flagellum-dependent cell motility
WP8W19C03_25650	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WP8W19C03_25660	COG0835	chemotaxis
WP8W19C03_25660	COG0784	Response regulator, receiver
WP8W19C03_25670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
WP8W19C03_25700	COG0622	Phosphoesterase
WP8W19C03_25710	COG4166	transmembrane transport
WP8W19C03_25730	COG1187	pseudouridine synthase activity
WP8W19C03_25740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8W19C03_25760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8W19C03_25770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8W19C03_25780	COG1882	Formate acetyltransferase
WP8W19C03_25790	COG1349	DNA-binding transcription factor activity
WP8W19C03_25800	COG4166	transmembrane transport
WP8W19C03_25850	COG1278	Cold shock
WP8W19C03_25900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WP8W19C03_25900	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
WP8W19C03_25910	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_25920	COG3433	isochorismatase activity
WP8W19C03_25920	COG1535	isochorismatase
WP8W19C03_25930	COG1021	2,3-dihydroxybenzoate-AMP ligase
WP8W19C03_25940	COG1169	isochorismate synthase
WP8W19C03_25950	COG4771	TonB-dependent receptor
WP8W19C03_25960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WP8W19C03_25970	COG1609	Transcriptional regulator
WP8W19C03_25980	COG0741	lytic transglycosylase activity
WP8W19C03_26000	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WP8W19C03_26020	COG2911	Protein conserved in bacteria
WP8W19C03_26030	COG0729	surface antigen
WP8W19C03_26050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8W19C03_26070	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WP8W19C03_26090	COG4134	Bacterial extracellular solute-binding protein
WP8W19C03_26110	COG4136	ATPase activity
WP8W19C03_26120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WP8W19C03_26130	COG2951	lytic endotransglycosylase activity
WP8W19C03_26140	COG1846	Transcriptional regulator
WP8W19C03_26160	COG0033	Phosphoglucomutase
WP8W19C03_26170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
WP8W19C03_26180	COG0596	Alpha beta hydrolase
WP8W19C03_26210	COG0716	FMN binding
WP8W19C03_26230	COG0735	belongs to the Fur family
WP8W19C03_26240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8W19C03_26260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_26260	COG2190	(PTS) system
WP8W19C03_26260	COG1263	PTS System
WP8W19C03_26270	COG0363	glucosamine-6-phosphate deaminase activity
WP8W19C03_26280	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WP8W19C03_26290	COG1940	carbohydrate kinase activity
WP8W19C03_26290	COG1846	Transcriptional regulator
WP8W19C03_26300	COG2194	sulfuric ester hydrolase activity
WP8W19C03_26310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
WP8W19C03_26310	COG2199	diguanylate cyclase activity
WP8W19C03_26320	COG3275	phosphorelay sensor kinase activity
WP8W19C03_26330	COG3279	Response regulator of the LytR AlgR family
WP8W19C03_26340	COG1966	Carbon starvation protein
WP8W19C03_26370	COG1566	PFAM secretion protein HlyD family protein
WP8W19C03_26380	COG1061	Type III restriction enzyme res subunit
WP8W19C03_26390	COG2027	D-alanyl-D-alanine carboxypeptidase
WP8W19C03_26400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP8W19C03_26410	COG3021	interspecies interaction between organisms
WP8W19C03_26430	COG1607	acyl-coa hydrolase
WP8W19C03_26440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WP8W19C03_26460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WP8W19C03_26460	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
WP8W19C03_26460	COG0674	pyruvate-flavodoxin oxidoreductase activity
WP8W19C03_26460	COG1013	pyruvate-flavodoxin oxidoreductase activity
WP8W19C03_26490	COG0633	Ferredoxin
WP8W19C03_26490	COG3217	Mosc domain protein beta barrel domain protein
WP8W19C03_26490	COG0633	Ferredoxin
WP8W19C03_26490	COG3217	Mosc domain protein beta barrel domain protein
WP8W19C03_26510	COG0501	Belongs to the peptidase M48B family
WP8W19C03_26520	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
WP8W19C03_26530	COG1073	alpha beta
WP8W19C03_26530	COG2226	methyltransferase
WP8W19C03_26540	COG0156	8-amino-7-oxononanoate synthase activity
WP8W19C03_26550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8W19C03_26560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
WP8W19C03_26590	COG0017	Asparaginyl-tRNA synthetase
WP8W19C03_26610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8W19C03_26630	COG1473	amidohydrolase
WP8W19C03_26640	COG3069	C4-dicarboxylate transmembrane transporter activity
WP8W19C03_26670	COG1393	Belongs to the ArsC family
WP8W19C03_26680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WP8W19C03_26690	COG1876	peptidase activity
WP8W19C03_26710	COG3263	regulation of cellular component size
WP8W19C03_26740	COG1280	lysine exporter protein (LysE YggA)
WP8W19C03_26800	COG0564	pseudouridine synthase activity
WP8W19C03_26820	COG1454	alcohol dehydrogenase
WP8W19C03_26900	COG2894	cell division
WP8W19C03_26920	COG4964	Belongs to the GSP D family
WP8W19C03_26980	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8W19C03_26990	COG0702	epimerase
WP8W19C03_27010	COG0095	Lipoate-protein ligase
WP8W19C03_27030	COG0577	efflux transmembrane transporter activity
WP8W19C03_27030	COG1136	(ABC) transporter
WP8W19C03_27040	COG1136	(ABC) transporter
WP8W19C03_27040	COG0577	efflux transmembrane transporter activity
WP8W19C03_27050	COG1136	(ABC) transporter
WP8W19C03_27050	COG0577	efflux transmembrane transporter activity
WP8W19C03_27060	COG1566	PFAM secretion protein HlyD family protein
WP8W19C03_27140	COG1285	pathogenesis
WP8W19C03_27200	COG0484	heat shock protein binding
WP8W19C03_27210	COG0443	Heat shock 70 kDa protein
WP8W19C03_27220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WP8W19C03_27230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WP8W19C03_27240	COG0497	DNA recombination
WP8W19C03_27250	COG1227	inorganic diphosphatase activity
WP8W19C03_27260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_27270	COG1136	(ABC) transporter
WP8W19C03_27270	COG0577	efflux transmembrane transporter activity
WP8W19C03_27310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
WP8W19C03_27330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8W19C03_27340	COG1091	dTDP-4-dehydrorhamnose reductase activity
WP8W19C03_27350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WP8W19C03_27360	COG0438	transferase activity, transferring glycosyl groups
WP8W19C03_27380	COG0438	transferase activity, transferring glycosyl groups
WP8W19C03_27400	COG0438	transferase activity, transferring glycosyl groups
WP8W19C03_27420	COG1216	Glycosyl transferase, family 2
WP8W19C03_27470	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
WP8W19C03_27490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WP8W19C03_27500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_27510	COG1309	transcriptional regulator
WP8W19C03_27540	COG1342	Belongs to the UPF0251 family
WP8W19C03_27580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WP8W19C03_27630	COG0813	purine-nucleoside phosphorylase activity
WP8W19C03_27660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
WP8W19C03_27670	COG0083	homoserine kinase activity
WP8W19C03_27690	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
WP8W19C03_27700	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
WP8W19C03_27710	COG1946	Acyl-CoA thioesterase
WP8W19C03_27740	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WP8W19C03_27760	COG0009	L-threonylcarbamoyladenylate synthase
WP8W19C03_27780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WP8W19C03_27790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8W19C03_27790	COG0512	Glutamine amidotransferase of anthranilate synthase
WP8W19C03_27800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WP8W19C03_27810	COG0135	phosphoribosylanthranilate isomerase activity
WP8W19C03_27810	COG0134	indole-3-glycerol-phosphate synthase activity
WP8W19C03_27820	COG0133	tryptophan synthase activity
WP8W19C03_27830	COG0159	tryptophan synthase activity
WP8W19C03_27850	COG1988	membrane-bound metal-dependent
WP8W19C03_27890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8W19C03_27920	COG0798	PFAM Bile acid sodium symporter
WP8W19C03_27980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
WP8W19C03_28000	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_28010	COG4988	ABC transporter
WP8W19C03_28020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
WP8W19C03_28060	COG1720	tRNA m6t6A37 methyltransferase activity
WP8W19C03_28070	COG3038	cytochrome b561
WP8W19C03_28090	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_28110	COG2862	Uncharacterized protein family, UPF0114
WP8W19C03_28140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WP8W19C03_28150	COG1396	sequence-specific DNA binding
WP8W19C03_28150	COG1917	Cupin 2, conserved barrel domain protein
WP8W19C03_28190	COG0531	amino acid
WP8W19C03_28210	COG0531	amino acid
WP8W19C03_28220	COG1283	sodium-dependent phosphate transmembrane transporter activity
WP8W19C03_28250	COG2974	May be involved in recombination
WP8W19C03_28270	COG0420	3'-5' exonuclease activity
WP8W19C03_28280	COG0419	ATPase involved in DNA repair
WP8W19C03_28290	COG3384	dioxygenase
WP8W19C03_28310	COG0469	pyruvate kinase activity
WP8W19C03_28320	COG3264	Mechanosensitive ion channel
WP8W19C03_28320	COG1196	nuclear chromosome segregation
WP8W19C03_28340	COG3590	peptidase
WP8W19C03_28350	COG3706	GGDEF domain
WP8W19C03_28360	COG2190	(PTS) system
WP8W19C03_28380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_28390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
WP8W19C03_28400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WP8W19C03_28430	COG2770	Histidine kinase
WP8W19C03_28430	COG3437	response regulator, receiver
WP8W19C03_28440	COG3409	Peptidoglycan-binding domain 1 protein
WP8W19C03_28440	COG3267	Type II secretory pathway component ExeA
WP8W19C03_28460	COG3031	protein transport across the cell outer membrane
WP8W19C03_28480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8W19C03_28490	COG1459	type II secretion system
WP8W19C03_28500	COG2165	general secretion pathway protein
WP8W19C03_28520	COG2165	general secretion pathway protein
WP8W19C03_28530	COG4795	General secretion pathway protein
WP8W19C03_28540	COG3156	type II secretion system protein K
WP8W19C03_28560	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
WP8W19C03_28580	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
WP8W19C03_28630	COG0561	phosphatase activity
WP8W19C03_28640	COG3623	hexulose-6-phosphate isomerase
WP8W19C03_28660	COG0670	Belongs to the BI1 family
WP8W19C03_28670	COG1289	transmembrane transporter activity
WP8W19C03_28680	COG2920	part of a sulfur-relay system
WP8W19C03_28690	COG0673	inositol 2-dehydrogenase activity
WP8W19C03_28760	COG2801	Transposase and inactivated derivatives
WP8W19C03_28780	COG1032	radical SAM domain protein
WP8W19C03_28800	COG1566	PFAM secretion protein HlyD family protein
WP8W19C03_28810	COG3706	GGDEF domain
WP8W19C03_28820	COG1752	Esterase of the alpha-beta hydrolase superfamily
WP8W19C03_28830	COG0531	amino acid
WP8W19C03_28890	COG0281	malic enzyme
WP8W19C03_28910	COG0534	Mate efflux family protein
WP8W19C03_28930	COG3706	GGDEF domain
WP8W19C03_28940	COG2233	PERMEase
WP8W19C03_28950	COG0095	Lipoate-protein ligase
WP8W19C03_28960	COG1115	amino acid carrier protein
WP8W19C03_28970	COG0019	diaminopimelate decarboxylase activity
WP8W19C03_28990	COG0678	peroxiredoxin activity
WP8W19C03_29040	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8W19C03_29050	COG3142	Participates in the control of copper homeostasis
WP8W19C03_29100	COG5002	protein histidine kinase activity
WP8W19C03_29110	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_29120	COG0346	lactoylglutathione lyase activity
WP8W19C03_29130	COG3284	Transcriptional regulator
WP8W19C03_29140	COG1012	belongs to the aldehyde dehydrogenase family
WP8W19C03_29160	COG0697	spore germination
WP8W19C03_29180	COG3290	protein histidine kinase activity
WP8W19C03_29190	COG0281	malic enzyme
WP8W19C03_29210	COG1846	Transcriptional regulator
WP8W19C03_29220	COG1566	PFAM secretion protein HlyD family protein
WP8W19C03_29280	COG0602	queuosine metabolic process
WP8W19C03_29290	COG1328	CTP reductase activity
WP8W19C03_29310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
WP8W19C03_29320	COG3115	cell septum assembly
WP8W19C03_29330	COG1196	nuclear chromosome segregation
WP8W19C03_29350	COG2860	membrane
WP8W19C03_29370	COG3108	Peptidase M15
WP8W19C03_29380	COG2989	Protein conserved in bacteria
WP8W19C03_29410	COG0463	Glycosyl transferase, family 2
WP8W19C03_29440	COG0366	Alpha amylase catalytic
WP8W19C03_29510	COG2199	diguanylate cyclase activity
WP8W19C03_29510	COG2203	Gaf domain
WP8W19C03_29530	COG3590	peptidase
WP8W19C03_29550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
WP8W19C03_29560	COG1982	Orn Lys Arg decarboxylase major
WP8W19C03_29570	COG0531	amino acid
WP8W19C03_29580	COG3710	Transcriptional regulator
WP8W19C03_29590	COG0531	amino acid
WP8W19C03_29630	COG0814	amino acid
WP8W19C03_29690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
WP8W19C03_29700	COG0739	heme binding
WP8W19C03_29710	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
WP8W19C03_29730	COG0251	oxidation-reduction process
WP8W19C03_29760	COG0583	DNA-binding transcription factor activity
WP8W19C03_29770	COG3321	synthase
WP8W19C03_29770	COG0604	alcohol dehydrogenase
WP8W19C03_29770	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_29780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WP8W19C03_29800	COG3091	SprT-like family
WP8W19C03_29820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WP8W19C03_29830	COG0189	ligase activity
WP8W19C03_29840	COG1678	Uncharacterized ACR, COG1678
WP8W19C03_29850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
WP8W19C03_29860	COG3104	oligopeptide transport
WP8W19C03_29890	COG0714	Associated with various cellular activities
WP8W19C03_29920	COG1115	amino acid carrier protein
WP8W19C03_29930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
WP8W19C03_29950	COG0825	malonyl-CoA metabolic process
WP8W19C03_29970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
WP8W19C03_29980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8W19C03_29990	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8W19C03_30000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
WP8W19C03_30010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WP8W19C03_30030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8W19C03_30040	COG0750	zinc metalloprotease
WP8W19C03_30050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
WP8W19C03_30060	COG0575	Belongs to the CDS family
WP8W19C03_30070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WP8W19C03_30080	COG0233	cytoplasmic translational termination
WP8W19C03_30090	COG0528	UMP kinase activity
WP8W19C03_30100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WP8W19C03_30110	COG0052	Belongs to the universal ribosomal protein uS2 family
WP8W19C03_30120	COG0024	Methionine aminopeptidase
WP8W19C03_30140	COG2171	N-acyltransferase activity
WP8W19C03_30160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_30160	COG1263	PTS System
WP8W19C03_30200	COG0564	pseudouridine synthase activity
WP8W19C03_30210	COG3098	single-species biofilm formation
WP8W19C03_30260	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
WP8W19C03_30280	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8W19C03_30280	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
WP8W19C03_30300	COG3706	GGDEF domain
WP8W19C03_30310	COG1611	Belongs to the LOG family
WP8W19C03_30320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
WP8W19C03_30330	COG0473	3-isopropylmalate dehydrogenase activity
WP8W19C03_30350	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
WP8W19C03_30360	COG2363	Small membrane protein
WP8W19C03_30380	COG0583	DNA-binding transcription factor activity
WP8W19C03_30390	COG0840	transmembrane signaling receptor activity
WP8W19C03_30400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8W19C03_30430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WP8W19C03_30440	COG1666	GTP binding
WP8W19C03_30460	COG2211	Major facilitator Superfamily
WP8W19C03_30470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WP8W19C03_30490	COG2813	Specifically methylates the guanine in position
WP8W19C03_30500	COG0271	Belongs to the BolA IbaG family
WP8W19C03_30510	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8W19C03_30520	COG1805	sodium ion transport
WP8W19C03_30530	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8W19C03_30540	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8W19C03_30550	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
WP8W19C03_30560	COG2871	sodium ion transport
WP8W19C03_30570	COG1477	protein flavinylation
WP8W19C03_30630	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WP8W19C03_30660	COG0300	oxidoreductase activity
WP8W19C03_30680	COG0415	Belongs to the DNA photolyase family
WP8W19C03_30690	COG0789	Transcriptional regulator
WP8W19C03_30700	COG3272	Protein of unknown function (DUF1722)
WP8W19C03_30760	COG0077	Prephenate dehydratase
WP8W19C03_30760	COG1605	Chorismate mutase
WP8W19C03_30910	COG3039	Transposase
WP8W19C03_30960	COG3328	transposase activity
WP8W19C03_30990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8W19C03_31060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8W19C03_31140	COG2916	Histone family protein nucleoid-structuring protein H-NS
WP8W19C03_31160	COG3039	Transposase
WP8W19C03_31170	COG5433	transposase activity
WP8W19C03_31210	COG5377	YqaJ viral recombinase family
WP8W19C03_31270	COG2003	Belongs to the UPF0758 family
WP8W19C03_31290	COG4735	regulation of single-species biofilm formation
WP8W19C03_31310	COG3328	transposase activity
WP8W19C03_31340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
WP8W19C03_31410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8W19C03_31460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WP8W19C03_31520	COG0840	transmembrane signaling receptor activity
WP8W19C03_31540	COG0300	oxidoreductase activity
WP8W19C03_31590	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
WP8W19C03_31670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WP8W19C03_31680	COG0826	peptidase U32
WP8W19C03_31690	COG1280	lysine exporter protein (LysE YggA)
WP8W19C03_31730	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_31750	COG2198	Histidine kinase
WP8W19C03_31750	COG0643	Histidine kinase
WP8W19C03_31770	COG0835	chemotaxis
WP8W19C03_31780	COG0840	transmembrane signaling receptor activity
WP8W19C03_31800	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
WP8W19C03_31810	COG2201	protein-glutamate methylesterase activity
WP8W19C03_31820	COG1185	polyribonucleotide nucleotidyltransferase activity
WP8W19C03_31830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
WP8W19C03_31840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
WP8W19C03_31850	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
WP8W19C03_31860	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WP8W19C03_31870	COG0195	Participates in both transcription termination and antitermination
WP8W19C03_31880	COG0779	Required for maturation of 30S ribosomal subunits
WP8W19C03_31890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WP8W19C03_31900	COG0149	triose-phosphate isomerase activity
WP8W19C03_31910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WP8W19C03_31920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
WP8W19C03_31940	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WP8W19C03_31950	COG1534	Rna-binding protein
WP8W19C03_31980	COG1360	Flagellar Motor Protein
WP8W19C03_31990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
WP8W19C03_32000	COG1722	exodeoxyribonuclease VII activity
WP8W19C03_32010	COG0142	geranyltranstransferase activity
WP8W19C03_32020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
WP8W19C03_32030	COG0737	Belongs to the 5'-nucleotidase family
WP8W19C03_32070	COG2204	response regulator
WP8W19C03_32080	COG0545	Peptidyl-prolyl cis-trans isomerase
WP8W19C03_32100	COG2900	Belongs to the SlyX family
WP8W19C03_32150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WP8W19C03_32160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
WP8W19C03_32170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8W19C03_32180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WP8W19C03_32210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8W19C03_32210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WP8W19C03_32220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WP8W19C03_32230	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
WP8W19C03_32250	COG0784	Response regulator, receiver
WP8W19C03_32250	COG2205	protein histidine kinase activity
WP8W19C03_32250	COG2198	Histidine kinase
WP8W19C03_32260	COG1879	ABC-type sugar transport system periplasmic component
WP8W19C03_32280	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_32290	COG3005	denitrification pathway
WP8W19C03_32310	COG3381	protein complex oligomerization
WP8W19C03_32350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8W19C03_32360	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WP8W19C03_32370	COG0511	ligase activity, forming carbon-carbon bonds
WP8W19C03_32380	COG0439	Biotin carboxylase
WP8W19C03_32390	COG3924	membrane
WP8W19C03_32400	COG4145	pantothenate transmembrane transporter activity
WP8W19C03_32410	COG1263	PTS System
WP8W19C03_32410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_32410	COG2190	(PTS) system
WP8W19C03_32420	COG0583	DNA-binding transcription factor activity
WP8W19C03_32430	COG0604	alcohol dehydrogenase
WP8W19C03_32440	COG2264	protein methyltransferase activity
WP8W19C03_32460	COG0778	Nitroreductase
WP8W19C03_32470	COG1902	pentaerythritol trinitrate reductase activity
WP8W19C03_32470	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8W19C03_32480	COG0616	signal peptide processing
WP8W19C03_32520	COG0848	biopolymer transport protein
WP8W19C03_32530	COG0811	peptide transport
WP8W19C03_32540	COG0811	peptide transport
WP8W19C03_32570	COG4174	ABC transporter (Permease)
WP8W19C03_32580	COG4239	(ABC) transporter, permease
WP8W19C03_32600	COG0444	Belongs to the ABC transporter superfamily
WP8W19C03_32610	COG4608	Belongs to the ABC transporter superfamily
WP8W19C03_32650	COG3416	Protein conserved in bacteria
WP8W19C03_32670	COG0741	lytic transglycosylase activity
WP8W19C03_32700	COG0488	(ABC) transporter
WP8W19C03_32720	COG2252	PERMEase
WP8W19C03_32730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WP8W19C03_32740	COG0840	transmembrane signaling receptor activity
WP8W19C03_32760	COG1278	Cold shock
WP8W19C03_32770	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WP8W19C03_32790	COG0688	phosphatidylethanolamine metabolic process
WP8W19C03_32800	COG4628	conserved protein (DUF2132)
WP8W19C03_32830	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WP8W19C03_32870	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WP8W19C03_32890	COG2195	Cleaves the N-terminal amino acid of tripeptides
WP8W19C03_32900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WP8W19C03_32910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
WP8W19C03_32920	COG3178	'Phosphotransferase
WP8W19C03_32930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
WP8W19C03_32940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WP8W19C03_32950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WP8W19C03_32960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WP8W19C03_32970	COG2967	ApaG domain
WP8W19C03_32980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
WP8W19C03_33010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WP8W19C03_33040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WP8W19C03_33050	COG0211	Belongs to the bacterial ribosomal protein bL27 family
WP8W19C03_33060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
WP8W19C03_33070	COG0142	geranyltranstransferase activity
WP8W19C03_33080	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
WP8W19C03_33090	COG0330	HflC and HflK could
WP8W19C03_33100	COG0330	HflC and HflK could
WP8W19C03_33110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WP8W19C03_33120	COG1923	regulation of RNA biosynthetic process
WP8W19C03_33130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WP8W19C03_33140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP8W19C03_33150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WP8W19C03_33170	COG0802	atpase or kinase
WP8W19C03_33180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WP8W19C03_33180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WP8W19C03_33220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WP8W19C03_33230	COG2011	ABC-type metal ion transport system permease component
WP8W19C03_33240	COG1464	Belongs to the NlpA lipoprotein family
WP8W19C03_33310	COG0784	Response regulator, receiver
WP8W19C03_33310	COG2198	Histidine kinase
WP8W19C03_33310	COG5002	protein histidine kinase activity
WP8W19C03_33380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WP8W19C03_33390	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WP8W19C03_33400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8W19C03_33410	COG2716	regulation of RNA biosynthetic process
WP8W19C03_33420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WP8W19C03_33440	COG3013	Belongs to the UPF0304 family
WP8W19C03_33460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
WP8W19C03_33470	COG0280	phosphate acetyltransferase
WP8W19C03_33470	COG0857	belongs to the CobB CobQ family
WP8W19C03_33480	COG1555	photosystem II stabilization
WP8W19C03_33490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WP8W19C03_33500	COG3104	oligopeptide transport
WP8W19C03_33510	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_33570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
WP8W19C03_33590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WP8W19C03_33600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WP8W19C03_33680	COG0440	acetolactate synthase activity
WP8W19C03_33690	COG0028	Belongs to the TPP enzyme family
WP8W19C03_33740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WP8W19C03_33750	COG0473	3-isopropylmalate dehydrogenase activity
WP8W19C03_33760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
WP8W19C03_33770	COG0066	3-isopropylmalate dehydratase activity
WP8W19C03_33800	COG4143	(ABC) transporter
WP8W19C03_33810	COG1178	ABC-type Fe3 transport system permease component
WP8W19C03_33820	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
WP8W19C03_33830	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WP8W19C03_33850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WP8W19C03_33890	COG0459	protein refolding
WP8W19C03_33900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WP8W19C03_33910	COG0534	Mate efflux family protein
WP8W19C03_33920	COG3030	protein affecting phage T7 exclusion by the F plasmid
WP8W19C03_33930	COG1027	Aspartate ammonia-lyase
WP8W19C03_33940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
WP8W19C03_33950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
WP8W19C03_33960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
WP8W19C03_33970	COG1610	YqeY-like protein
WP8W19C03_33990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WP8W19C03_34020	COG0151	Belongs to the GarS family
WP8W19C03_34030	COG0138	bifunctional purine biosynthesis protein purh
WP8W19C03_34050	COG3036	rescue of stalled ribosome
WP8W19C03_34060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8W19C03_34070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WP8W19C03_34090	COG0673	inositol 2-dehydrogenase activity
WP8W19C03_34110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8W19C03_34120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8W19C03_34140	COG0583	DNA-binding transcription factor activity
WP8W19C03_34150	COG0477	Major facilitator Superfamily
WP8W19C03_34180	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_34200	COG2425	protein containing a von Willebrand factor type A (vWA) domain
WP8W19C03_34230	COG0456	acetyltransferase
WP8W19C03_34250	COG1022	Amp-dependent synthetase and ligase
WP8W19C03_34260	COG2918	glutathione biosynthetic process
WP8W19C03_34270	COG0612	Peptidase, M16
WP8W19C03_34280	COG1238	metal cluster binding
WP8W19C03_34290	COG1064	alcohol dehydrogenase
WP8W19C03_34340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8W19C03_34350	COG0359	binds to the 23S rRNA
WP8W19C03_34360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
WP8W19C03_34370	COG0360	Binds together with S18 to 16S ribosomal RNA
WP8W19C03_34380	COG1914	H( )-stimulated, divalent metal cation uptake system
WP8W19C03_34390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8W19C03_34410	COG0776	regulation of translation
WP8W19C03_34440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
WP8W19C03_34470	COG0560	Phosphoserine phosphatase
WP8W19C03_34490	COG0813	purine-nucleoside phosphorylase activity
WP8W19C03_34500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
WP8W19C03_34510	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
WP8W19C03_34520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
WP8W19C03_34540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8W19C03_34550	COG0084	hydrolase, TatD family'
WP8W19C03_34580	COG1854	S-ribosylhomocysteine lyase activity
WP8W19C03_34610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8W19C03_34610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
WP8W19C03_34700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WP8W19C03_34710	COG1047	Peptidyl-prolyl cis-trans
WP8W19C03_34720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WP8W19C03_34730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
WP8W19C03_34740	COG0196	riboflavin kinase activity
WP8W19C03_34750	COG0728	peptidoglycan biosynthetic process
WP8W19C03_34760	COG0268	Binds directly to 16S ribosomal RNA
WP8W19C03_34770	COG0640	Transcriptional regulator
WP8W19C03_34780	COG0583	DNA-binding transcription factor activity
WP8W19C03_34800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8W19C03_34810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WP8W19C03_34820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WP8W19C03_34830	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
WP8W19C03_34840	COG1051	belongs to the nudix hydrolase family
WP8W19C03_34860	COG3066	DNA modification
WP8W19C03_34880	COG0335	large ribosomal subunit rRNA binding
WP8W19C03_34890	COG0336	Belongs to the RNA methyltransferase TrmD family
WP8W19C03_34900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WP8W19C03_34910	COG0228	four-way junction DNA binding
WP8W19C03_34920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WP8W19C03_34930	COG4137	Cytochrome C assembly protein
WP8W19C03_34940	COG4536	flavin adenine dinucleotide binding
WP8W19C03_34960	COG1017	nitric oxide dioxygenase activity
WP8W19C03_34960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WP8W19C03_34970	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
WP8W19C03_34980	COG0039	L-malate dehydrogenase activity
WP8W19C03_34990	COG4160	amino acid transport
WP8W19C03_35000	COG4215	(ABC) transporter
WP8W19C03_35010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_35020	COG1126	abc transporter atp-binding protein
WP8W19C03_35030	COG1438	arginine binding
WP8W19C03_35040	COG2837	iron assimilation
WP8W19C03_35050	COG3842	ATPase activity
WP8W19C03_35070	COG1840	ABC-type Fe3 transport system, periplasmic component
WP8W19C03_35080	COG0347	Belongs to the P(II) protein family
WP8W19C03_35120	COG3022	response to hydroperoxide
WP8W19C03_35150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
WP8W19C03_35160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
WP8W19C03_35170	COG0762	integral membrane protein
WP8W19C03_35180	COG1872	DUF167
WP8W19C03_35200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
WP8W19C03_35210	COG0583	DNA-binding transcription factor activity
WP8W19C03_35240	COG1929	Belongs to the glycerate kinase type-1 family
WP8W19C03_35250	COG2610	gluconate transmembrane transporter activity
WP8W19C03_35260	COG3835	regulator
WP8W19C03_35270	COG3112	Uncharacterised protein family (UPF0231)
WP8W19C03_35330	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_35410	COG1448	Aminotransferase
WP8W19C03_35440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
WP8W19C03_35450	COG1328	CTP reductase activity
WP8W19C03_35500	COG0543	2 iron, 2 sulfur cluster binding
WP8W19C03_35500	COG0633	Ferredoxin
WP8W19C03_35530	COG0840	transmembrane signaling receptor activity
WP8W19C03_35540	COG3397	chitin binding
WP8W19C03_35550	COG0583	DNA-binding transcription factor activity
WP8W19C03_35560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WP8W19C03_35570	COG4208	sulfate ABC transporter
WP8W19C03_35580	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WP8W19C03_35600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WP8W19C03_35610	COG3174	membrane
WP8W19C03_35620	COG0110	maltose O-acetyltransferase activity
WP8W19C03_35650	COG1011	Hydrolase
WP8W19C03_35660	COG0494	nUDIX hydrolase
WP8W19C03_35670	COG1218	3'(2'),5'-bisphosphate nucleotidase
WP8W19C03_35680	COG0814	amino acid
WP8W19C03_35690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8W19C03_35720	COG0626	cystathionine gamma-synthase activity
WP8W19C03_35730	COG0460	homoserine dehydrogenase
WP8W19C03_35730	COG0527	aspartate kinase activity
WP8W19C03_35740	COG0306	phosphate transporter
WP8W19C03_35750	COG1392	Phosphate transport regulator
WP8W19C03_35770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WP8W19C03_35780	COG2813	Specifically methylates the guanine in position
WP8W19C03_35790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
WP8W19C03_35800	COG0297	glycogen (starch) synthase activity
WP8W19C03_35830	COG1757	Na H antiporter
WP8W19C03_35840	COG0316	Belongs to the HesB IscA family
WP8W19C03_35860	COG0038	chloride channel
WP8W19C03_35870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WP8W19C03_35900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
WP8W19C03_35900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8W19C03_35910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
WP8W19C03_35920	COG0564	pseudouridine synthase activity
WP8W19C03_35940	COG0110	maltose O-acetyltransferase activity
WP8W19C03_35950	COG0366	Alpha amylase catalytic
WP8W19C03_35960	COG1263	PTS System
WP8W19C03_35960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WP8W19C03_36000	COG0252	asparaginase activity
WP8W19C03_36010	COG1253	flavin adenine dinucleotide binding
WP8W19C03_36020	COG0586	Pfam SNARE associated Golgi protein
WP8W19C03_36030	COG1686	Belongs to the peptidase S11 family
WP8W19C03_36050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
WP8W19C03_36060	COG0527	aspartate kinase activity
WP8W19C03_36070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WP8W19C03_36090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WP8W19C03_36100	COG1546	Belongs to the CinA family
WP8W19C03_36110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
WP8W19C03_36120	COG4667	esterase of the alpha-beta hydrolase superfamily
WP8W19C03_36140	COG1346	cytolysis
WP8W19C03_36150	COG1380	Effector of murein hydrolase LrgA
WP8W19C03_36160	COG0583	DNA-binding transcription factor activity
WP8W19C03_36180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WP8W19C03_36210	COG3039	Transposase
WP8W19C03_36230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
WP8W19C03_36240	COG2022	thiamine diphosphate biosynthetic process
WP8W19C03_36260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WP8W19C03_36270	COG0352	thiamine-phosphate diphosphorylase activity
WP8W19C03_36280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WP8W19C03_36320	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_36330	COG0642	Histidine kinase
WP8W19C03_36340	COG0189	ligase activity
WP8W19C03_36430	COG0477	Major facilitator Superfamily
WP8W19C03_36470	COG0312	modulator of DNA gyrase
WP8W19C03_36480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WP8W19C03_36500	COG3164	Protein of unknown function
WP8W19C03_36510	COG1530	ribonuclease E activity
WP8W19C03_36520	COG0424	maF-like protein
WP8W19C03_36530	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
WP8W19C03_36540	COG1792	Involved in formation and maintenance of cell shape
WP8W19C03_36550	COG1077	Cell shape determining protein MreB Mrl
WP8W19C03_36600	COG4968	Prepilin-type N-terminal cleavage methylation domain
WP8W19C03_36610	COG4969	Belongs to the N-Me-Phe pilin family
WP8W19C03_36640	COG1459	type II secretion system
WP8W19C03_36650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
WP8W19C03_36740	COG2200	EAL domain
WP8W19C03_36740	COG2199	diguanylate cyclase activity
WP8W19C03_36770	COG4943	cyclic-guanylate-specific phosphodiesterase activity
WP8W19C03_36780	COG0387	Pfam Sodium calcium exchanger
WP8W19C03_36790	COG2986	histidine ammonia-lyase
WP8W19C03_36800	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WP8W19C03_36810	COG0010	Belongs to the arginase family
WP8W19C03_36820	COG1228	amidohydrolase
WP8W19C03_36830	COG2188	Transcriptional regulator
WP8W19C03_36840	COG0288	reversible hydration of carbon dioxide
WP8W19C03_36860	COG2177	Part of the ABC transporter FtsEX involved in
WP8W19C03_36870	COG2884	Cell division ATP-binding protein ftsE
WP8W19C03_36880	COG0552	protein localization to endoplasmic reticulum
WP8W19C03_36890	COG0742	ribosomal rna small subunit methyltransferase
WP8W19C03_36940	COG2249	NAD(P)H dehydrogenase (quinone) activity
WP8W19C03_36950	COG0583	DNA-binding transcription factor activity
WP8W19C03_36960	COG4221	oxidoreductase activity
WP8W19C03_36990	COG1770	oligopeptidase
WP8W19C03_37020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WP8W19C03_37040	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
WP8W19C03_37060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8W19C03_37080	COG2095	MarC family integral membrane protein
WP8W19C03_37100	COG1301	dicarboxylic acid transport
WP8W19C03_37150	COG3714	YhhN family
WP8W19C03_37210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WP8W19C03_37220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8W19C03_37230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
WP8W19C03_37240	COG0049	tRNA binding
WP8W19C03_37250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
WP8W19C03_37260	COG2168	tRNA wobble position uridine thiolation
WP8W19C03_37270	COG2923	Belongs to the DsrF TusC family
WP8W19C03_37280	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
WP8W19C03_37300	COG2964	Protein conserved in bacteria
WP8W19C03_37310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WP8W19C03_37320	COG0085	RNA polymerase activity
WP8W19C03_37330	COG0222	ribosome binding
WP8W19C03_37340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
WP8W19C03_37350	COG0081	regulation of translation
WP8W19C03_37360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WP8W19C03_37370	COG0250	Participates in transcription elongation, termination and antitermination
WP8W19C03_37390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WP8W19C03_37420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
WP8W19C03_37430	COG0569	domain protein
WP8W19C03_37440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8W19C03_37500	COG4191	Histidine kinase
WP8W19C03_37500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WP8W19C03_37510	COG3005	denitrification pathway
WP8W19C03_37520	COG0243	molybdopterin cofactor binding
WP8W19C03_37540	COG2205	protein histidine kinase activity
WP8W19C03_37550	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_37620	COG2204	response regulator
WP8W19C03_37640	COG2205	protein histidine kinase activity
WP8W19C03_37670	COG1028	Short-chain dehydrogenase reductase Sdr
WP8W19C03_37680	COG0517	IMP dehydrogenase activity
WP8W19C03_37680	COG0516	GMP reductase activity
WP8W19C03_37690	COG5413	integral membrane protein
WP8W19C03_37710	COG1522	sequence-specific DNA binding
WP8W19C03_37720	COG2502	aspartate--ammonia ligase
WP8W19C03_37730	COG0542	response to heat
WP8W19C03_37750	COG0564	pseudouridine synthase activity
WP8W19C03_37760	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WP8W19C03_37770	COG0446	pyridine nucleotide-disulphide oxidoreductase
WP8W19C03_37790	COG3681	Belongs to the UPF0597 family
WP8W19C03_37800	COG2964	Protein conserved in bacteria
WP8W19C03_37820	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
WP8W19C03_37830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
WP8W19C03_37840	COG1979	alcohol dehydrogenase
WP8W19C03_37850	COG2207	Transcriptional regulator
WP8W19C03_37860	COG3040	lipid binding
WP8W19C03_37890	COG0583	DNA-binding transcription factor activity
WP8W19C03_37910	COG0540	Belongs to the ATCase OTCase family
WP8W19C03_37920	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
WP8W19C03_37930	COG1438	arginine binding
WP8W19C03_37940	COG1288	antiporter activity
WP8W19C03_37950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
WP8W19C03_38010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WP8W19C03_38030	COG3078	GTPase activator activity
WP8W19C03_38050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
WP8W19C03_38070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WP8W19C03_38080	COG0408	coproporphyrinogen oxidase activity
WP8W19C03_38090	COG0009	L-threonylcarbamoyladenylate synthase
WP8W19C03_38110	COG0551	DNA topoisomerase type I activity
WP8W19C03_38120	COG2922	Belongs to the Smg family
WP8W19C03_38130	COG0758	DNA mediated transformation
WP8W19C03_38140	COG1652	LysM domain
WP8W19C03_38150	COG0242	peptide deformylase activity
WP8W19C03_38160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WP8W19C03_38170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WP8W19C03_38170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WP8W19C03_38180	COG0569	domain protein
WP8W19C03_38190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8W19C03_38210	COG0174	glutamine synthetase
WP8W19C03_38250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WP8W19C03_38260	COG1322	Protein conserved in bacteria
WP8W19C03_38300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WP8W19C03_38310	COG0583	DNA-binding transcription factor activity
WP8W19C03_38320	COG0519	Catalyzes the synthesis of GMP from XMP
WP8W19C03_38320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8W19C03_38350	COG1396	sequence-specific DNA binding
WP8W19C03_38360	COG1012	belongs to the aldehyde dehydrogenase family
WP8W19C03_38380	COG2962	Rard protein
WP8W19C03_38400	COG0840	transmembrane signaling receptor activity
WP8W19C03_38410	COG2391	methyltransferase activity
WP8W19C03_38430	COG1309	transcriptional regulator
WP8W19C03_38460	COG0129	dihydroxy-acid dehydratase activity
WP8W19C03_38480	COG3978	acetolactate synthase activity
WP8W19C03_38500	COG0606	chelatase, subunit chli
WP8W19C03_38510	COG0204	Acyl-transferase
WP8W19C03_38520	COG0204	Acyl-transferase
WP8W19C03_38530	COG1683	Conserved Protein
WP8W19C03_38550	COG1335	isochorismatase
WP8W19C03_38570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WP8W19C03_38580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WP8W19C03_38600	COG3084	Protein conserved in bacteria
WP8W19C03_38610	COG4251	negative regulation of phosphorylation
WP8W19C03_38610	COG3706	GGDEF domain
WP8W19C03_38610	COG5001	Diguanylate cyclase
WP8W19C03_38610	COG2203	Gaf domain
WP8W19C03_38640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WP8W19C03_38650	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
WP8W19C03_38660	COG1561	YicC-like family, N-terminal region
WP8W19C03_38670	COG0583	DNA-binding transcription factor activity
WP8W19C03_38700	COG0583	DNA-binding transcription factor activity
WP8W19C03_38780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WP8W19C03_38790	COG0385	Bile acid
WP8W19C03_38800	COG0531	amino acid
WP8W19C03_38810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
WP8W19C03_38820	COG0531	amino acid
WP8W19C03_38830	COG2731	YhcH YjgK YiaL family protein
WP8W19C03_38840	COG3250	beta-galactosidase activity
WP8W19C03_38850	COG1609	Transcriptional regulator
WP8W19C03_38860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
WP8W19C03_38880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
WP8W19C03_38890	COG3074	FtsZ-dependent cytokinesis
WP8W19C03_38910	COG1045	serine acetyltransferase
WP8W19C03_38930	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_38940	COG2205	protein histidine kinase activity
WP8W19C03_38950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WP8W19C03_38960	COG0534	Mate efflux family protein
WP8W19C03_38990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WP8W19C03_39000	COG2937	Belongs to the GPAT DAPAT family
WP8W19C03_39010	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WP8W19C03_39020	COG3161	chorismate lyase activity
WP8W19C03_39080	COG0604	alcohol dehydrogenase
WP8W19C03_39090	COG1609	Transcriptional regulator
WP8W19C03_39100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
WP8W19C03_39130	COG1519	Transferase
WP8W19C03_39140	COG0859	PFAM glycosyl transferase family 9
WP8W19C03_39150	COG0463	Glycosyl transferase, family 2
WP8W19C03_39160	COG0859	PFAM glycosyl transferase family 9
WP8W19C03_39170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WP8W19C03_39180	COG2990	Protein conserved in bacteria
WP8W19C03_39190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
WP8W19C03_39210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
WP8W19C03_39220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
WP8W19C03_39230	COG2003	Belongs to the UPF0758 family
WP8W19C03_39240	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WP8W19C03_39250	COG0756	dUTP diphosphatase activity
WP8W19C03_39260	COG1309	transcriptional regulator
WP8W19C03_39270	COG0668	transmembrane transport
WP8W19C03_39280	COG0166	Belongs to the GPI family
WP8W19C03_39290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WP8W19C03_39330	COG1042	CoA-binding domain protein
WP8W19C03_39330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WP8W19C03_39330	COG0045	succinate-CoA ligase (ADP-forming) activity
WP8W19C03_39350	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
WP8W19C03_39360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
WP8W19C03_39370	COG1739	Uncharacterized protein family UPF0029
WP8W19C03_39380	COG0006	proline dipeptidase activity
WP8W19C03_39390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WP8W19C03_39400	COG1024	Enoyl-CoA hydratase
WP8W19C03_39400	COG1250	3-hydroxyacyl-CoA dehydrogenase
WP8W19C03_39410	COG0183	Belongs to the thiolase family
WP8W19C03_39420	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_39430	COG2205	protein histidine kinase activity
WP8W19C03_39460	COG0425	Belongs to the sulfur carrier protein TusA family
WP8W19C03_39470	COG0251	oxidation-reduction process
WP8W19C03_39480	COG2885	chlorophyll binding
WP8W19C03_39490	COG2818	Glycosylase
WP8W19C03_39500	COG0752	glycyl-tRNA synthetase alpha subunit
WP8W19C03_39510	COG0751	glycine-tRNA ligase activity
WP8W19C03_39530	COG2200	EAL domain
WP8W19C03_39560	COG2188	Transcriptional regulator
WP8W19C03_39590	COG1609	Transcriptional regulator
WP8W19C03_39650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WP8W19C03_39680	COG2960	long-chain fatty acid transporting porin activity
WP8W19C03_39690	COG5001	Diguanylate cyclase
WP8W19C03_39710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WP8W19C03_39740	COG3118	belongs to the thioredoxin family
WP8W19C03_39750	COG0513	Belongs to the DEAD box helicase family
WP8W19C03_39760	COG0248	Ppx GppA phosphatase
WP8W19C03_39780	COG0742	ribosomal rna small subunit methyltransferase
WP8W19C03_39810	COG3469	chitinase activity
WP8W19C03_39820	COG3397	chitin binding
WP8W19C03_39840	COG0084	hydrolase, TatD family'
WP8W19C03_39850	COG0805	protein transport
WP8W19C03_39860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8W19C03_39870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WP8W19C03_39880	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
WP8W19C03_39890	COG3165	ubiquinone biosynthetic process from chorismate
WP8W19C03_39900	COG2226	methyltransferase
WP8W19C03_39910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
WP8W19C03_39920	COG0402	S-adenosylhomocysteine deaminase activity
WP8W19C03_39930	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WP8W19C03_39960	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
WP8W19C03_39970	COG0848	biopolymer transport protein
WP8W19C03_39980	COG0811	peptide transport
WP8W19C03_39990	COG0811	peptide transport
WP8W19C03_40010	COG2771	luxR family
WP8W19C03_40020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WP8W19C03_40030	COG1349	DNA-binding transcription factor activity
WP8W19C03_40040	COG0745	RESPONSE REGULATOR receiver
WP8W19C03_40050	COG2205	protein histidine kinase activity
WP8W19C03_40080	COG4452	Inner membrane protein CreD
WP8W19C03_40110	COG0297	glycogen (starch) synthase activity
WP8W19C03_40110	COG0438	transferase activity, transferring glycosyl groups
WP8W19C03_40200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
WP8W19C03_40210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
WP8W19C03_40220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
WP8W19C03_40230	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
WP8W19C03_40240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WP8W19C03_40250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WP8W19C03_40260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
WP8W19C03_40270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
WP8W19C03_40290	COG0356	it plays a direct role in the translocation of protons across the membrane
WP8W19C03_40310	COG1475	DNA binding
WP8W19C03_40320	COG1192	Involved in chromosome partitioning
WP8W19C03_40330	COG0357	Ribosomal RNA small subunit methyltransferase G
WP8W19C03_40340	COG0445	tRNA wobble uridine modification
WP8W19C03_40350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
WP8W19C03_40370	COG4615	Cyclic peptide transporter
WP8W19C03_40380	COG1120	ATPase activity
WP8W19C03_40390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WP8W19C03_40410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WP8W19C03_40420	COG0706	membrane insertase activity
WP8W19C03_40430	COG0594	ribonuclease P activity
WP8W19C03_40440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
WP8W19C03_P10050	COG1525	nuclease
WP8W19C03_P10100	COG1192	Involved in chromosome partitioning
WP8W19C03_P10190	COG3385	transposase activity
WP8W19C03_P10260	COG0583	DNA-binding transcription factor activity
WP8W19C03_P10280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8W19C03_P10290	COG0625	glutathione transferase activity
WP8W19C03_P10330	COG0519	Catalyzes the synthesis of GMP from XMP
WP8W19C03_P10330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WP8W19C03_P10350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8W19C03_P10390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8W19C03_P10410	COG0604	alcohol dehydrogenase
WP8W19C03_P10420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WP8W19C03_P10440	COG0183	Belongs to the thiolase family
WP8W19C03_P10450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
WP8W19C03_P10480	COG0783	Belongs to the Dps family
WP8W19C03_P10640	COG0038	chloride channel
WP8W19C03_P10670	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8W19C03_P10710	COG0840	transmembrane signaling receptor activity
WP8W19C03_P10730	COG3385	transposase activity
WP8W19C03_P10760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WP8W19C03_P10770	COG1061	Type III restriction enzyme res subunit
WP8W19C03_P10780	COG1002	Type II restriction enzyme, methylase subunits
WP8W19C03_P10810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
WP8W19C03_P10940	COG0640	Transcriptional regulator
WP8W19C03_P11130	COG2801	Transposase and inactivated derivatives
WP8W19C03_P11280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP8W19C03_P11290	COG4804	nuclease activity
WP8W19C03_P11310	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
WP8W19C03_P11320	COG4804	nuclease activity
WP8W19C03_P11340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
WP8W19C03_P11370	COG4584	PFAM Integrase catalytic
WP8W19C03_P11380	COG1484	DNA-dependent DNA replication
WP8W19C03_P11420	COG2801	Transposase and inactivated derivatives
WP8W19C03_P11550	COG2974	May be involved in recombination
WP8W19C03_P20100	COG3385	transposase activity
WP8W19C03_P20160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WP8W19C03_P20170	COG0625	glutathione transferase activity
WP8W19C03_P20220	COG1192	Involved in chromosome partitioning
WP8W19C03_P20270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8W19C03_P20280	COG3041	Addiction module toxin RelE StbE family
WP8W19C03_P20380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
WP8W19C03_P20430	COG2608	mercury ion transmembrane transporter activity
WP8W19C03_P20490	COG2176	DNA-directed DNA polymerase activity
WP8W19C03_P20490	COG5002	protein histidine kinase activity
WP8W19C03_P30060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs