locus-tag	class	description
CVS42_00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CVS42_00015	COG0706	membrane insertase activity
CVS42_00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CVS42_00025	COG0594	ribonuclease P activity
CVS42_00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CVS42_00050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CVS42_00055	COG0592	DNA-directed DNA polymerase activity
CVS42_00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CVS42_00065	COG0187	DNA topoisomerase II activity
CVS42_00075	COG2378	regulation of single-species biofilm formation
CVS42_00085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CVS42_00090	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS42_00095	COG0071	Belongs to the small heat shock protein (HSP20) family
CVS42_00100	COG3977	Valine--pyruvate aminotransferase
CVS42_00115	COG2814	Major facilitator Superfamily
CVS42_00120	COG0745	RESPONSE REGULATOR receiver
CVS42_00125	COG2205	protein histidine kinase activity
CVS42_00150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS42_00155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_00155	COG4191	Histidine kinase
CVS42_00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_00170	COG1309	transcriptional regulator
CVS42_00200	COG0469	pyruvate kinase activity
CVS42_00205	COG2271	Major facilitator Superfamily
CVS42_00210	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS42_00230	COG0561	phosphatase activity
CVS42_00235	COG2267	carboxylic ester hydrolase activity
CVS42_00245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS42_00250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS42_00255	COG1758	RNA polymerase activity
CVS42_00270	COG0859	PFAM glycosyl transferase family 9
CVS42_00275	COG3642	lipopolysaccharide core region biosynthetic process
CVS42_00315	COG0589	response to stress
CVS42_00320	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS42_00325	COG1528	Iron-storage protein
CVS42_00330	COG2081	HI0933 family
CVS42_00335	COG3275	phosphorelay sensor kinase activity
CVS42_00340	COG3279	Response regulator of the LytR AlgR family
CVS42_00345	COG2223	nitrite transmembrane transporter activity
CVS42_00350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CVS42_00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CVS42_00370	COG0583	DNA-binding transcription factor activity
CVS42_00410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CVS42_00415	COG2166	iron-sulfur cluster assembly
CVS42_00420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CVS42_00435	COG3245	cytochrome
CVS42_00440	COG1063	alcohol dehydrogenase
CVS42_00455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS42_00465	COG3307	-O-antigen
CVS42_00505	COG1280	lysine exporter protein (LysE YggA)
CVS42_00560	COG1943	Transposase
CVS42_00565	COG0210	DNA helicase
CVS42_00595	COG0737	Belongs to the 5'-nucleotidase family
CVS42_00605	COG2239	Acts as a magnesium transporter
CVS42_00610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_00610	COG1648	precorrin-2 dehydrogenase activity
CVS42_00615	COG2116	formate transmembrane transporter activity
CVS42_00620	COG2146	nitrite reductase [NAD(P)H] activity
CVS42_00625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS42_00630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CVS42_00635	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CVS42_00650	COG0018	arginyl-trna synthetase
CVS42_00660	COG1595	DNA-templated transcription, initiation
CVS42_00670	COG1968	undecaprenyl-diphosphatase activity
CVS42_00675	COG2017	converts alpha-aldose to the beta-anomer
CVS42_00680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CVS42_00685	COG1085	galactose-1-phosphate uridylyltransferase
CVS42_00690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS42_00695	COG1609	Transcriptional regulator
CVS42_00700	COG3250	beta-galactosidase activity
CVS42_00710	COG1129	ABC transporter
CVS42_00715	COG4211	Belongs to the binding-protein-dependent transport system permease family
CVS42_00725	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_00740	COG0366	Alpha amylase catalytic
CVS42_00755	COG0443	Heat shock 70 kDa protein
CVS42_00760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS42_00765	COG3045	CreA protein
CVS42_00780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CVS42_00785	COG0174	glutamine synthetase
CVS42_00805	COG3842	ATPase activity
CVS42_00810	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS42_00815	COG1177	transmembrane transport
CVS42_00820	COG2258	MOSC domain
CVS42_00835	COG2050	protein possibly involved in aromatic compounds catabolism
CVS42_00840	COG0514	ATP-dependent DNA helicase (RecQ)
CVS42_00850	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CVS42_00860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CVS42_00865	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS42_00885	COG0254	rRNA binding
CVS42_00890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CVS42_00900	COG0702	epimerase
CVS42_00905	COG0814	amino acid
CVS42_00910	COG0281	malic enzyme
CVS42_00915	COG1295	ribonuclease BN
CVS42_00920	COG1490	D-aminoacyl-tRNA deacylase activity
CVS42_00925	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CVS42_00930	COG0456	acetyltransferase
CVS42_00940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CVS42_00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_00950	COG2610	gluconate transmembrane transporter activity
CVS42_00955	COG3265	gluconokinase activity
CVS42_00960	COG0129	dihydroxy-acid dehydratase activity
CVS42_00965	COG0800	Aldolase
CVS42_00980	COG1609	Transcriptional regulator
CVS42_00990	COG4942	peptidase
CVS42_00995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CVS42_01000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_01005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CVS42_01010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CVS42_01015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CVS42_01015	COG0316	Belongs to the HesB IscA family
CVS42_01020	COG1040	competence protein
CVS42_01025	COG0596	Alpha beta hydrolase
CVS42_01045	COG2183	response to ionizing radiation
CVS42_01050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS42_01055	COG0745	RESPONSE REGULATOR receiver
CVS42_01070	COG0051	transcription antitermination factor activity, RNA binding
CVS42_01075	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CVS42_01080	COG0088	Forms part of the polypeptide exit tunnel
CVS42_01085	COG0089	rRNA binding
CVS42_01090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CVS42_01095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CVS42_01100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CVS42_01105	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CVS42_01110	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CVS42_01115	COG0255	Belongs to the universal ribosomal protein uL29 family
CVS42_01120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CVS42_01125	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CVS42_01130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CVS42_01135	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CVS42_01140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CVS42_01145	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CVS42_01150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CVS42_01155	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CVS42_01160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CVS42_01165	COG1841	ribosomal large subunit assembly
CVS42_01170	COG0200	Binds to the 23S rRNA
CVS42_01175	COG0201	protein transport
CVS42_01180	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS42_01185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CVS42_01190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CVS42_01195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CVS42_01200	COG0202	RNA polymerase activity
CVS42_01205	COG0203	ribosomal protein L17
CVS42_01240	COG4771	TonB-dependent receptor
CVS42_01245	COG3706	GGDEF domain
CVS42_01255	COG0745	RESPONSE REGULATOR receiver
CVS42_01265	COG0583	DNA-binding transcription factor activity
CVS42_01275	COG1741	Belongs to the pirin family
CVS42_01280	COG2259	Doxx family
CVS42_01285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CVS42_01290	COG1074	ATP-dependent DNA helicase activity
CVS42_01295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CVS42_01310	COG3706	GGDEF domain
CVS42_01340	COG1175	transmembrane transport
CVS42_01350	COG3842	ATPase activity
CVS42_01380	COG2873	o-acetylhomoserine
CVS42_01390	COG4533	DNA binding
CVS42_01395	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CVS42_01410	COG5380	lipid catabolic process
CVS42_01415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CVS42_01420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS42_01445	COG0753	catalase activity
CVS42_01450	COG0454	-acetyltransferase
CVS42_01450	COG0456	acetyltransferase
CVS42_01475	COG2927	DNA polymerase III (CHI subunit)
CVS42_01480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS42_01485	COG0795	lipopolysaccharide-transporting ATPase activity
CVS42_01490	COG0795	lipopolysaccharide-transporting ATPase activity
CVS42_01620	COG4695	Portal protein
CVS42_01690	COG3620	sequence-specific DNA binding
CVS42_01710	COG4974	Belongs to the 'phage' integrase family
CVS42_01715	COG0582	viral genome integration into host DNA
CVS42_01735	COG0840	transmembrane signaling receptor activity
CVS42_01740	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVS42_01745	COG1049	propionate catabolic process, 2-methylcitrate cycle
CVS42_01750	COG2200	EAL domain
CVS42_01760	COG0523	cobalamin synthesis protein
CVS42_01765	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_01780	COG0477	Major facilitator Superfamily
CVS42_01795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CVS42_01800	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CVS42_01835	COG0165	Argininosuccinate lyase
CVS42_01840	COG0137	argininosuccinate synthase activity
CVS42_01850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS42_01855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CVS42_01865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CVS42_01880	COG0582	viral genome integration into host DNA
CVS42_01885	COG2926	Belongs to the UPF0265 family
CVS42_01895	COG0561	phosphatase activity
CVS42_01905	COG1546	Belongs to the CinA family
CVS42_01905	COG1058	Belongs to the CinA family
CVS42_01915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CVS42_01925	COG1522	sequence-specific DNA binding
CVS42_01930	COG1368	sulfuric ester hydrolase activity
CVS42_01965	COG4221	oxidoreductase activity
CVS42_01980	COG1979	alcohol dehydrogenase
CVS42_01985	COG1803	Methylglyoxal synthase
CVS42_02010	COG1444	tRNA N-acetyltransferase activity
CVS42_02015	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_02020	COG0784	Response regulator, receiver
CVS42_02020	COG0835	chemotaxis
CVS42_02030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CVS42_02035	COG2949	membrane
CVS42_02040	COG3291	Pkd domain containing protein
CVS42_02045	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_02050	COG1441	menaquinone biosynthetic process
CVS42_02055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CVS42_02060	COG0596	Alpha beta hydrolase
CVS42_02065	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CVS42_02070	COG1169	isochorismate synthase
CVS42_02075	COG1575	Belongs to the MenA family. Type 1 subfamily
CVS42_02095	COG0513	Belongs to the DEAD box helicase family
CVS42_02100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_02105	COG1988	membrane-bound metal-dependent
CVS42_02110	COG1671	Belongs to the UPF0178 family
CVS42_02130	COG0484	heat shock protein binding
CVS42_02135	COG3722	fumarate hydratase activity
CVS42_02140	COG0246	Mannitol dehydrogenase
CVS42_02145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_02145	COG2213	PTS system mannitol-specific
CVS42_02150	COG1560	Kdo2-lipid A biosynthetic process
CVS42_02155	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CVS42_02155	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CVS42_02160	COG1538	Outer membrane efflux protein
CVS42_02165	COG0494	nUDIX hydrolase
CVS42_02170	COG3151	Protein conserved in bacteria
CVS42_02180	COG3150	esterase
CVS42_02185	COG0187	DNA topoisomerase II activity
CVS42_02200	COG0583	DNA-binding transcription factor activity
CVS42_02210	COG3104	oligopeptide transport
CVS42_02240	COG2084	Dehydrogenase
CVS42_02245	COG0583	DNA-binding transcription factor activity
CVS42_02250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS42_02270	COG0204	Acyl-transferase
CVS42_02275	COG1842	Phage shock protein A
CVS42_02290	COG2827	Endonuclease containing a URI domain
CVS42_02305	COG1573	uracil-dna glycosylase
CVS42_02310	COG0697	spore germination
CVS42_02315	COG0583	DNA-binding transcription factor activity
CVS42_02320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CVS42_02325	COG1121	(ABC) transporter
CVS42_02330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CVS42_02350	COG0739	heme binding
CVS42_02360	COG3068	Protein conserved in bacteria
CVS42_02380	COG0617	tRNA 3'-terminal CCA addition
CVS42_02385	COG1194	a g-specific adenine glycosylase
CVS42_02390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CVS42_02400	COG3111	PFAM Bacterial OB fold (BOF) protein
CVS42_02405	COG3240	lipase activity
CVS42_02410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CVS42_02410	COG2885	chlorophyll binding
CVS42_02415	COG3706	GGDEF domain
CVS42_02420	COG0557	exoribonuclease II activity
CVS42_02510	COG3501	Rhs element vgr protein
CVS42_02550	COG0673	inositol 2-dehydrogenase activity
CVS42_02560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CVS42_02565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS42_02590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CVS42_02600	COG2153	protein acetylation
CVS42_02605	COG0513	Belongs to the DEAD box helicase family
CVS42_02610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CVS42_02635	COG0735	belongs to the Fur family
CVS42_02640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS42_02675	COG0840	transmembrane signaling receptor activity
CVS42_02685	COG4166	transmembrane transport
CVS42_02695	COG0110	maltose O-acetyltransferase activity
CVS42_02705	COG1024	Enoyl-CoA hydratase
CVS42_02720	COG4221	oxidoreductase activity
CVS42_02725	COG0442	prolyl-tRNA aminoacylation
CVS42_02730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_02740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS42_02740	COG3008	intermembrane lipid transfer
CVS42_02745	COG2995	paraquat-inducible protein a
CVS42_02755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_02765	COG2203	Gaf domain
CVS42_02765	COG3706	GGDEF domain
CVS42_02765	COG4251	negative regulation of phosphorylation
CVS42_02765	COG5001	Diguanylate cyclase
CVS42_02770	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CVS42_02785	COG2771	luxR family
CVS42_02795	COG0840	transmembrane signaling receptor activity
CVS42_02800	COG0632	four-way junction helicase activity
CVS42_02805	COG2255	four-way junction helicase activity
CVS42_02815	COG1294	oxidase, subunit
CVS42_02820	COG4890	Cyd operon protein YbgT
CVS42_02825	COG3790	cyd operon protein YbgE
CVS42_02830	COG0824	Thioesterase
CVS42_02835	COG0811	peptide transport
CVS42_02850	COG0823	Involved in the tonB-independent uptake of proteins
CVS42_02855	COG2885	chlorophyll binding
CVS42_02860	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CVS42_02895	COG0733	neurotransmitter:sodium symporter activity
CVS42_02905	COG0733	neurotransmitter:sodium symporter activity
CVS42_02920	COG0561	phosphatase activity
CVS42_02935	COG1522	sequence-specific DNA binding
CVS42_02970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CVS42_02975	COG1640	4-alpha-glucanotransferase
CVS42_02985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS42_02990	COG0676	glucose-6-phosphate 1-epimerase activity
CVS42_02995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CVS42_03000	COG0840	transmembrane signaling receptor activity
CVS42_03005	COG1585	Membrane protein implicated in regulation of membrane protease activity
CVS42_03010	COG0330	HflC and HflK could
CVS42_03015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_03015	COG1648	precorrin-2 dehydrogenase activity
CVS42_03020	COG0175	sulfate reduction
CVS42_03025	COG2895	sulfate adenylyltransferase (ATP) activity
CVS42_03030	COG0471	metal ion transport
CVS42_03030	COG3273	potassium ion transport
CVS42_03035	COG0529	Catalyzes the synthesis of activated sulfate
CVS42_03050	COG0840	transmembrane signaling receptor activity
CVS42_03085	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CVS42_03100	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CVS42_03105	COG0784	Response regulator, receiver
CVS42_03105	COG3437	response regulator, receiver
CVS42_03115	COG2076	Multidrug Resistance protein
CVS42_03120	COG2076	Multidrug Resistance protein
CVS42_03125	COG0346	lactoylglutathione lyase activity
CVS42_03130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS42_03135	COG1643	Atp-dependent helicase
CVS42_03145	COG1489	DNA binding
CVS42_03150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CVS42_03155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_03165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CVS42_03170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CVS42_03175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CVS42_03210	COG0842	Transport permease protein
CVS42_03215	COG1131	(ABC) transporter
CVS42_03230	COG0163	prenyltransferase activity
CVS42_03235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS42_03240	COG0671	phosphoesterase, PA-phosphatase related
CVS42_03245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CVS42_03250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_03255	COG1151	hydroxylamine reductase activity
CVS42_03260	COG0783	Belongs to the Dps family
CVS42_03265	COG3023	N-Acetylmuramoyl-L-alanine amidase
CVS42_03270	COG4807	Protein conserved in bacteria
CVS42_03280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CVS42_03285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CVS42_03290	COG3956	TIGRFAM MazG family protein
CVS42_03295	COG0504	CTP synthase activity
CVS42_03300	COG0148	phosphopyruvate hydratase activity
CVS42_03350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CVS42_03360	COG0488	(ABC) transporter
CVS42_03380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_03395	COG1794	racemase activity, acting on amino acids and derivatives
CVS42_03405	COG2731	YhcH YjgK YiaL family protein
CVS42_03415	COG0668	transmembrane transport
CVS42_03420	COG1376	ErfK ybiS ycfS ynhG family protein
CVS42_03430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS42_03435	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CVS42_03440	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CVS42_03450	COG0585	pseudouridine synthase activity
CVS42_03455	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CVS42_03460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CVS42_03465	COG1238	metal cluster binding
CVS42_03480	COG1902	pentaerythritol trinitrate reductase activity
CVS42_03495	COG2957	Belongs to the agmatine deiminase family
CVS42_03500	COG0154	amidase activity
CVS42_03540	COG0513	Belongs to the DEAD box helicase family
CVS42_03545	COG2199	diguanylate cyclase activity
CVS42_03545	COG2203	Gaf domain
CVS42_03555	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CVS42_03605	COG2816	NAD+ diphosphatase activity
CVS42_03640	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CVS42_03650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS42_03655	COG4991	sh3 domain protein
CVS42_03665	COG2816	NAD+ diphosphatase activity
CVS42_03670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CVS42_03675	COG1940	carbohydrate kinase activity
CVS42_03680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CVS42_03685	COG0126	phosphoglycerate kinase activity
CVS42_03690	COG0191	fructose-bisphosphate aldolase activity
CVS42_03695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_03740	COG0354	folic acid binding
CVS42_03745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CVS42_03755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CVS42_03760	COG1595	DNA-templated transcription, initiation
CVS42_03765	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CVS42_03770	COG3026	antisigma factor binding
CVS42_03780	COG0481	GTPase activity
CVS42_03785	COG0681	Belongs to the peptidase S26 family
CVS42_03800	COG1381	Involved in DNA repair and RecF pathway recombination
CVS42_03805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CVS42_03820	COG2350	Protein conserved in bacteria
CVS42_03825	COG2917	probably involved in intracellular septation
CVS42_03830	COG0076	glutamate decarboxylase activity
CVS42_03835	COG1272	protein, Hemolysin III
CVS42_03840	COG2985	domain, Protein
CVS42_03840	COG0569	domain protein
CVS42_03860	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CVS42_03890	COG1858	cytochrome C peroxidase
CVS42_03900	COG2313	pseudouridylate synthase activity
CVS42_03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_03940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS42_03945	COG1765	OsmC-like protein
CVS42_03960	COG3954	Phosphoribulokinase
CVS42_03965	COG3089	Belongs to the UPF0270 family
CVS42_03970	COG2203	Gaf domain
CVS42_03970	COG5001	Diguanylate cyclase
CVS42_03970	COG4251	negative regulation of phosphorylation
CVS42_03970	COG3706	GGDEF domain
CVS42_03975	COG0429	hydrolase of the alpha beta-hydrolase fold
CVS42_03980	COG0835	chemotaxis
CVS42_03980	COG0784	Response regulator, receiver
CVS42_03990	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CVS42_03995	COG1047	Peptidyl-prolyl cis-trans
CVS42_04000	COG2900	Belongs to the SlyX family
CVS42_04010	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS42_04015	COG2204	response regulator
CVS42_04035	COG0737	Belongs to the 5'-nucleotidase family
CVS42_04050	COG0305	Participates in initiation and elongation during chromosome replication
CVS42_04055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS42_04060	COG0432	Pfam Uncharacterised protein family UPF0047
CVS42_04065	COG3340	Belongs to the peptidase S51 family
CVS42_04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_04090	COG3721	Heme iron utilization protein
CVS42_04095	COG0748	coenzyme F420 binding
CVS42_04135	COG3501	Rhs element vgr protein
CVS42_04145	COG2814	Major facilitator Superfamily
CVS42_04155	COG3655	Transcriptional regulator
CVS42_04165	COG5002	protein histidine kinase activity
CVS42_04165	COG0784	Response regulator, receiver
CVS42_04165	COG2205	protein histidine kinase activity
CVS42_04175	COG3706	GGDEF domain
CVS42_04190	COG3397	chitin binding
CVS42_04235	COG0784	Response regulator, receiver
CVS42_04235	COG0835	chemotaxis
CVS42_04240	COG2755	lipolytic protein G-D-S-L family
CVS42_04245	COG4181	ATPase activity
CVS42_04250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CVS42_04255	COG1090	epimerase
CVS42_04260	COG2200	EAL domain
CVS42_04265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_04270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CVS42_04275	COG3171	Protein conserved in bacteria
CVS42_04280	COG2066	Belongs to the glutaminase family
CVS42_04285	COG2897	thiosulfate sulfurtransferase activity
CVS42_04300	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS42_04310	COG2966	Psort location CytoplasmicMembrane, score
CVS42_04315	COG3610	response to peptide
CVS42_04330	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CVS42_04335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CVS42_04340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CVS42_04355	COG0786	glutamate:sodium symporter activity
CVS42_04360	COG0252	asparaginase activity
CVS42_04365	COG3139	Protein of unknown function (DUF1315)
CVS42_04385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CVS42_04390	COG0321	lipoyl(octanoyl) transferase activity
CVS42_04395	COG2921	Belongs to the UPF0250 family
CVS42_04400	COG1686	Belongs to the peptidase S11 family
CVS42_04405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS42_04410	COG2951	lytic endotransglycosylase activity
CVS42_04415	COG0772	Belongs to the SEDS family
CVS42_04420	COG0768	penicillin binding
CVS42_04425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CVS42_04430	COG0799	negative regulation of ribosome biogenesis
CVS42_04435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CVS42_04450	COG0495	leucyl-tRNA aminoacylation
CVS42_04455	COG2888	peptidyl-tyrosine sulfation
CVS42_04460	COG0312	modulator of DNA gyrase
CVS42_04470	COG0716	FMN binding
CVS42_04475	COG4974	Belongs to the 'phage' integrase family
CVS42_04480	COG3706	GGDEF domain
CVS42_04480	COG0745	RESPONSE REGULATOR receiver
CVS42_04485	COG1970	mechanosensitive ion channel activity
CVS42_04500	COG0789	Transcriptional regulator
CVS42_04505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CVS42_04510	COG4535	Mg2 and Co2 transporter CorC
CVS42_04515	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CVS42_04520	COG1702	phosphate starvation-inducible protein PhoH
CVS42_04525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS42_04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_04535	COG1335	isochorismatase
CVS42_04545	COG3706	GGDEF domain
CVS42_04555	COG3706	GGDEF domain
CVS42_04565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CVS42_04575	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CVS42_04585	COG0516	GMP reductase activity
CVS42_04595	COG0642	Histidine kinase
CVS42_04600	COG0745	RESPONSE REGULATOR receiver
CVS42_04610	COG4221	oxidoreductase activity
CVS42_04635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_04650	COG3214	Protein conserved in bacteria
CVS42_04660	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_04665	COG0700	Nucleoside recognition
CVS42_04670	COG3366	ferrous iron transmembrane transporter activity
CVS42_04675	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS42_04680	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CVS42_04685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CVS42_04690	COG1053	succinate dehydrogenase
CVS42_04700	COG0584	glycerophosphoryl diester phosphodiesterase
CVS42_04705	COG1511	domain protein
CVS42_04705	COG3264	Mechanosensitive ion channel
CVS42_04715	COG0739	heme binding
CVS42_04725	COG0583	DNA-binding transcription factor activity
CVS42_04745	COG0583	DNA-binding transcription factor activity
CVS42_04750	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CVS42_04780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CVS42_04785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CVS42_04795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CVS42_04800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CVS42_04810	COG0180	Tryptophanyl-tRNA synthetase
CVS42_04825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CVS42_04835	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_04850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_04860	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVS42_04860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_04860	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVS42_04860	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVS42_04865	COG0366	Alpha amylase catalytic
CVS42_04875	COG0443	Heat shock 70 kDa protein
CVS42_04880	COG2214	Heat shock protein DnaJ domain protein
CVS42_04905	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CVS42_04915	COG0490	domain, Protein
CVS42_04915	COG0471	metal ion transport
CVS42_04960	COG0012	GTP binding
CVS42_04965	COG0193	aminoacyl-tRNA hydrolase activity
CVS42_04970	COG0737	Belongs to the 5'-nucleotidase family
CVS42_04975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CVS42_04985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CVS42_04990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CVS42_04995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CVS42_05000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CVS42_05005	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS42_05015	COG2912	Transglutaminase-like superfamily
CVS42_05020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CVS42_05035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CVS42_05050	COG1881	PFAM PEBP family protein
CVS42_05070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CVS42_05080	COG0583	DNA-binding transcription factor activity
CVS42_05085	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_05090	COG0616	signal peptide processing
CVS42_05100	COG2211	Major facilitator Superfamily
CVS42_05105	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVS42_05115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_05145	COG3724	N-succinylarginine dihydrolase activity
CVS42_05150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CVS42_05160	COG0840	transmembrane signaling receptor activity
CVS42_05170	COG2971	BadF BadG BcrA BcrD
CVS42_05180	COG4608	Belongs to the ABC transporter superfamily
CVS42_05185	COG0444	Belongs to the ABC transporter superfamily
CVS42_05190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_05205	COG0784	Response regulator, receiver
CVS42_05205	COG2205	protein histidine kinase activity
CVS42_05230	COG3385	transposase activity
CVS42_05240	COG3220	belongs to the UPF0276 family
CVS42_05270	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_05275	COG1289	transmembrane transporter activity
CVS42_05280	COG0303	'Molybdopterin
CVS42_05285	COG0746	molybdenum cofactor guanylyltransferase activity
CVS42_05295	COG4662	Binding-protein-dependent transport system inner membrane component
CVS42_05310	COG3852	Histidine kinase
CVS42_05320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CVS42_05355	COG3383	formate dehydrogenase (NAD+) activity
CVS42_05355	COG3383	formate dehydrogenase (NAD+) activity
CVS42_05360	COG0437	4 iron, 4 sulfur cluster binding
CVS42_05380	COG0281	malic enzyme
CVS42_05400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_05435	COG1737	Transcriptional regulator
CVS42_05440	COG0469	pyruvate kinase activity
CVS42_05460	COG1677	Flagellar hook-basal body complex protein FliE
CVS42_05470	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS42_05520	COG1987	bacterial-type flagellum assembly
CVS42_05525	COG1684	flagellar biosynthetic protein fliR
CVS42_05535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CVS42_05545	COG0455	bacterial-type flagellum organization
CVS42_05560	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CVS42_05565	COG0643	Histidine kinase
CVS42_05565	COG2198	Histidine kinase
CVS42_05570	COG2201	protein-glutamate methylesterase activity
CVS42_05575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_05580	COG1360	Flagellar Motor Protein
CVS42_05585	COG1192	Involved in chromosome partitioning
CVS42_05595	COG0835	chemotaxis
CVS42_05610	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_05615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_05620	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CVS42_05625	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CVS42_05630	COG1138	Cytochrome C-type biogenesis protein
CVS42_05635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CVS42_05640	COG4235	cytochrome complex assembly
CVS42_05640	COG3088	subunit of a heme lyase
CVS42_05650	COG2853	Lipoprotein
CVS42_05660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CVS42_05665	COG2850	peptidyl-arginine hydroxylation
CVS42_05670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CVS42_05675	COG2915	High frequency lysogenization protein hflD homolog
CVS42_05680	COG0482	sulfurtransferase activity
CVS42_05690	COG1187	pseudouridine synthase activity
CVS42_05700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_05705	COG2271	Major facilitator Superfamily
CVS42_05710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_05710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_05710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_05730	COG1609	Transcriptional regulator
CVS42_05735	COG1263	PTS System
CVS42_05735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_05740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CVS42_05765	COG4792	protein secretion
CVS42_05770	COG4791	protein targeting
CVS42_05775	COG4794	Type iii secretion
CVS42_05780	COG4790	Type iii secretion
CVS42_05785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS42_05850	COG0457	Tetratricopeptide repeat
CVS42_05940	COG1317	bacterial-type flagellum organization
CVS42_05945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CVS42_05955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_05960	COG1960	acyl-CoA dehydrogenase activity
CVS42_05970	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CVS42_05990	COG0464	growth
CVS42_06045	COG2003	Belongs to the UPF0758 family
CVS42_06120	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_06145	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_06175	COG2200	EAL domain
CVS42_06175	COG2203	Gaf domain
CVS42_06175	COG2199	diguanylate cyclase activity
CVS42_06190	COG2205	protein histidine kinase activity
CVS42_06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_06210	COG2197	response regulator
CVS42_06240	COG2826	transposase and inactivated derivatives, IS30 family
CVS42_06250	COG4932	domain protein
CVS42_06250	COG5492	domain, Protein
CVS42_06300	COG2205	protein histidine kinase activity
CVS42_06300	COG0784	Response regulator, receiver
CVS42_06310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CVS42_06315	COG2867	negative regulation of translational initiation
CVS42_06325	COG1473	amidohydrolase
CVS42_06330	COG1960	acyl-CoA dehydrogenase activity
CVS42_06335	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS42_06340	COG0121	glutamine amidotransferase
CVS42_06360	COG2205	protein histidine kinase activity
CVS42_06360	COG0784	Response regulator, receiver
CVS42_06370	COG2197	response regulator
CVS42_06375	COG3850	Histidine kinase
CVS42_06380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CVS42_06385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_06395	COG0243	molybdopterin cofactor binding
CVS42_06400	COG0437	4 iron, 4 sulfur cluster binding
CVS42_06405	COG0348	domain, Protein
CVS42_06415	COG3005	denitrification pathway
CVS42_06420	COG0521	Mo-molybdopterin cofactor biosynthetic process
CVS42_06425	COG0315	cyclic pyranopterin monophosphate synthase activity
CVS42_06430	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CVS42_06435	COG0314	molybdopterin synthase activity
CVS42_06450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CVS42_06455	COG2267	carboxylic ester hydrolase activity
CVS42_06470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS42_06480	COG0302	gtp cyclohydrolase
CVS42_06485	COG0840	transmembrane signaling receptor activity
CVS42_06490	COG0840	transmembrane signaling receptor activity
CVS42_06495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CVS42_06505	COG0583	DNA-binding transcription factor activity
CVS42_06510	COG2353	YceI-like domain
CVS42_06535	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_06545	COG1166	arginine decarboxylase activity
CVS42_06555	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CVS42_06575	COG0814	amino acid
CVS42_06585	COG3681	Belongs to the UPF0597 family
CVS42_06590	COG2964	Protein conserved in bacteria
CVS42_06600	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CVS42_06610	COG0436	Aminotransferase
CVS42_06620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVS42_06625	COG1196	nuclear chromosome segregation
CVS42_06625	COG0741	lytic transglycosylase activity
CVS42_06625	COG0739	heme binding
CVS42_06640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_06650	COG0788	formyltetrahydrofolate deformylase activity
CVS42_06655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS42_06675	COG0791	NLP P60 protein
CVS42_06680	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CVS42_06690	COG0471	metal ion transport
CVS42_06700	COG1376	ErfK ybiS ycfS ynhG family protein
CVS42_06700	COG1388	LysM domain
CVS42_06710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_06715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_06720	COG0745	RESPONSE REGULATOR receiver
CVS42_06725	COG5002	protein histidine kinase activity
CVS42_06725	COG5000	phosphorelay sensor kinase activity
CVS42_06750	COG1388	LysM domain
CVS42_06750	COG0741	lytic transglycosylase activity
CVS42_06755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS42_06760	COG2226	methyltransferase
CVS42_06765	COG0328	RNA-DNA hybrid ribonuclease activity
CVS42_06770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS42_06780	COG3437	response regulator, receiver
CVS42_06780	COG0784	Response regulator, receiver
CVS42_06785	COG2375	cellular response to nickel ion
CVS42_06790	COG4771	TonB-dependent receptor
CVS42_06795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_06800	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CVS42_06805	COG1120	ATPase activity
CVS42_06810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS42_06820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_06850	COG0708	Exodeoxyribonuclease III
CVS42_06885	COG3132	Protein of unknown function, DUF480
CVS42_06890	COG3300	MHYT domain
CVS42_06890	COG5001	Diguanylate cyclase
CVS42_06900	COG2841	Protein conserved in bacteria
CVS42_06940	COG1309	transcriptional regulator
CVS42_06975	COG3152	Membrane
CVS42_06990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_07005	COG2207	Transcriptional regulator
CVS42_07010	COG0538	isocitrate dehydrogenase activity
CVS42_07020	COG3048	D-serine ammonia-lyase activity
CVS42_07025	COG2610	gluconate transmembrane transporter activity
CVS42_07030	COG0583	DNA-binding transcription factor activity
CVS42_07040	COG0791	NLP P60 protein
CVS42_07045	COG0583	DNA-binding transcription factor activity
CVS42_07050	COG0450	alkyl hydroperoxide reductase
CVS42_07060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS42_07070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS42_07075	COG1882	Formate acetyltransferase
CVS42_07085	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_07085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_07120	COG0259	pyridoxamine-phosphate oxidase activity
CVS42_07175	COG0483	inositol monophosphate 1-phosphatase activity
CVS42_07185	COG0625	glutathione transferase activity
CVS42_07190	COG2814	Major facilitator Superfamily
CVS42_07200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CVS42_07210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_07215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CVS42_07225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CVS42_07230	COG0509	glycine decarboxylation via glycine cleavage system
CVS42_07235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS42_07235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CVS42_07240	COG0840	transmembrane signaling receptor activity
CVS42_07265	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CVS42_07270	COG0574	Belongs to the PEP-utilizing enzyme family
CVS42_07270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS42_07285	COG1464	Belongs to the NlpA lipoprotein family
CVS42_07290	COG3083	sulfuric ester hydrolase activity
CVS42_07295	COG3082	Protein of unknown function (DUF1414)
CVS42_07300	COG3081	Nucleoid-associated protein
CVS42_07310	COG1175	transmembrane transport
CVS42_07320	COG3842	ATPase activity
CVS42_07350	COG4783	chaperone-mediated protein folding
CVS42_07360	COG1393	Belongs to the ArsC family
CVS42_07380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_07390	COG2431	L-lysine efflux transmembrane transporter activity
CVS42_07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_07405	COG4215	(ABC) transporter
CVS42_07410	COG4160	amino acid transport
CVS42_07415	COG0564	pseudouridine synthase activity
CVS42_07430	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CVS42_07440	COG0625	glutathione transferase activity
CVS42_07450	COG2801	Transposase and inactivated derivatives
CVS42_07465	COG0367	asparagine synthase
CVS42_07475	COG4651	solute:proton antiporter activity
CVS42_07475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CVS42_07480	COG0647	UMP catabolic process
CVS42_07485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVS42_07495	COG1902	pentaerythritol trinitrate reductase activity
CVS42_07500	COG1253	flavin adenine dinucleotide binding
CVS42_07510	COG0277	FAD linked oxidase domain protein
CVS42_07510	COG0247	lactate metabolic process
CVS42_07520	COG2050	protein possibly involved in aromatic compounds catabolism
CVS42_07525	COG0513	Belongs to the DEAD box helicase family
CVS42_07550	COG3634	alkyl hydroperoxide reductase activity
CVS42_07555	COG0450	alkyl hydroperoxide reductase
CVS42_07560	COG0517	IMP dehydrogenase activity
CVS42_07565	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CVS42_07570	COG0343	queuine tRNA-ribosyltransferase activity
CVS42_07575	COG1862	Preprotein translocase
CVS42_07580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_07585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_07630	COG1104	cysteine desulfurase activity
CVS42_07635	COG0822	iron-sulfur transferase activity
CVS42_07645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS42_07650	COG0443	Heat shock 70 kDa protein
CVS42_07655	COG0633	Ferredoxin
CVS42_07670	COG0105	UTP biosynthetic process
CVS42_07675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CVS42_07695	COG0124	histidyl-tRNA synthetase
CVS42_07700	COG2976	Protein conserved in bacteria
CVS42_07705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_07710	COG1160	GTP binding
CVS42_07715	COG1645	bacterial-type flagellum-dependent swarming motility
CVS42_07725	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS42_07730	COG0047	phosphoribosylformylglycinamidine synthase activity
CVS42_07730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CVS42_07735	COG2056	Na+-H+ antiporter family
CVS42_07740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CVS42_07745	COG0671	phosphoesterase, PA-phosphatase related
CVS42_07750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS42_07755	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS42_07765	COG0101	tRNA pseudouridine synthase activity
CVS42_07770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CVS42_07775	COG0285	dihydrofolate synthase activity
CVS42_07780	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CVS42_07785	COG0393	Putative heavy-metal-binding
CVS42_07795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CVS42_07795	COG1648	precorrin-2 dehydrogenase activity
CVS42_07800	COG2221	Nitrite and sulphite reductase 4Fe-4S
CVS42_07815	COG4667	esterase of the alpha-beta hydrolase superfamily
CVS42_07820	COG1619	proteins homologs of microcin C7 resistance protein MccF
CVS42_07825	COG1368	sulfuric ester hydrolase activity
CVS42_07835	COG0527	aspartate kinase activity
CVS42_07840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CVS42_07840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CVS42_07845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CVS42_07865	COG0596	Alpha beta hydrolase
CVS42_07880	COG1136	(ABC) transporter
CVS42_07895	COG2814	Major facilitator Superfamily
CVS42_07915	COG0672	)-iron permease
CVS42_07985	COG0393	Putative heavy-metal-binding
CVS42_08040	COG0582	viral genome integration into host DNA
CVS42_08060	COG0659	secondary active sulfate transmembrane transporter activity
CVS42_08145	COG2003	Belongs to the UPF0758 family
CVS42_08185	COG3311	Transcriptional regulator
CVS42_08190	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_08205	COG0346	lactoylglutathione lyase activity
CVS42_08225	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CVS42_08245	COG3501	Rhs element vgr protein
CVS42_08280	COG0582	viral genome integration into host DNA
CVS42_08285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CVS42_08290	COG0326	Molecular chaperone. Has ATPase activity
CVS42_08295	COG4172	Belongs to the ABC transporter superfamily
CVS42_08300	COG4172	Belongs to the ABC transporter superfamily
CVS42_08305	COG4171	peptide transport system, permease
CVS42_08310	COG4168	peptide transport system, permease
CVS42_08320	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CVS42_08325	COG1842	Phage shock protein A
CVS42_08340	COG3106	COG3106 Predicted ATPase
CVS42_08345	COG3768	UPF0283 membrane protein
CVS42_08355	COG2154	pterin-4-alpha-carbinolamine dehydratase
CVS42_08375	COG2199	diguanylate cyclase activity
CVS42_08380	COG2885	chlorophyll binding
CVS42_08385	COG0861	Integral membrane protein TerC family
CVS42_08420	COG2910	NAD(P)H-binding
CVS42_08425	COG0583	DNA-binding transcription factor activity
CVS42_08430	COG0583	DNA-binding transcription factor activity
CVS42_08435	COG2271	Major facilitator Superfamily
CVS42_08445	COG1335	isochorismatase
CVS42_08455	COG0583	DNA-binding transcription factor activity
CVS42_08460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CVS42_08470	COG0583	DNA-binding transcription factor activity
CVS42_08475	COG2723	6-phospho-beta-galactosidase activity
CVS42_08480	COG1944	ATP diphosphatase activity
CVS42_08485	COG2116	formate transmembrane transporter activity
CVS42_08490	COG1882	Formate acetyltransferase
CVS42_08495	COG2983	Belongs to the UPF0260 family
CVS42_08510	COG0058	SHG alpha-glucan phosphorylase activity
CVS42_08515	COG0471	metal ion transport
CVS42_08520	COG3118	belongs to the thioredoxin family
CVS42_08530	COG1132	(ABC) transporter
CVS42_08535	COG1132	(ABC) transporter
CVS42_08545	COG2501	S4 domain
CVS42_08560	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS42_08600	COG2009	succinate dehydrogenase
CVS42_08605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CVS42_08610	COG1053	succinate dehydrogenase
CVS42_08620	COG0567	Dehydrogenase, E1 component
CVS42_08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS42_08630	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS42_08640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_08650	COG3842	ATPase activity
CVS42_08655	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS42_08665	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CVS42_08675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_08690	COG4235	cytochrome complex assembly
CVS42_08690	COG3088	subunit of a heme lyase
CVS42_08700	COG1138	Cytochrome C-type biogenesis protein
CVS42_08705	COG3301	Polysulphide reductase, NrfD
CVS42_08710	COG0437	4 iron, 4 sulfur cluster binding
CVS42_08715	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CVS42_08730	COG0247	lactate metabolic process
CVS42_08735	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CVS42_08740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CVS42_08745	COG3012	SEC-C Motif Domain Protein
CVS42_08750	COG0840	transmembrane signaling receptor activity
CVS42_08755	COG1846	Transcriptional regulator
CVS42_08755	COG1940	carbohydrate kinase activity
CVS42_08765	COG0730	response to heat
CVS42_08770	COG0583	DNA-binding transcription factor activity
CVS42_08785	COG3593	DNA synthesis involved in DNA repair
CVS42_08820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CVS42_08825	COG1011	Hydrolase
CVS42_08840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CVS42_08845	COG2832	Protein of unknown function (DUF454)
CVS42_08850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CVS42_08860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CVS42_08865	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CVS42_08880	COG1560	Kdo2-lipid A biosynthetic process
CVS42_08885	COG1560	Kdo2-lipid A biosynthetic process
CVS42_08910	COG0417	DNA replication proofreading
CVS42_08925	COG1451	nucleotide metabolic process
CVS42_08940	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS42_08955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_08955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CVS42_08960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS42_08965	COG2985	domain, Protein
CVS42_08965	COG0569	domain protein
CVS42_08975	COG0556	nucleotide-excision repair
CVS42_08985	COG0586	Pfam SNARE associated Golgi protein
CVS42_08990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CVS42_08995	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_09010	COG4681	YaeQ
CVS42_09070	COG0307	riboflavin synthase, alpha
CVS42_09080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CVS42_09085	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CVS42_09090	COG0697	spore germination
CVS42_09095	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CVS42_09135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CVS42_09145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CVS42_09150	COG2894	cell division
CVS42_09155	COG0850	regulation of cytokinetic process
CVS42_09160	COG3100	YcgL domain-containing protein
CVS42_09165	COG1760	l-serine dehydratase
CVS42_09175	COG1760	l-serine dehydratase
CVS42_09180	COG3123	guanosine phosphorylase activity
CVS42_09190	COG0205	6-phosphofructokinase activity
CVS42_09200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CVS42_09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS42_09215	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CVS42_09220	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CVS42_09225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CVS42_09240	COG0242	peptide deformylase activity
CVS42_09275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS42_09280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CVS42_09285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS42_09295	COG0549	Belongs to the carbamate kinase family
CVS42_09300	COG0697	spore germination
CVS42_09305	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CVS42_09305	COG3608	succinylglutamate desuccinylase aspartoacylase
CVS42_09310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CVS42_09315	COG2068	MobA-Related Protein
CVS42_09320	COG0493	'glutamate synthase
CVS42_09320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_09325	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_09330	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS42_09335	COG2080	2 iron, 2 sulfur cluster binding
CVS42_09335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS42_09340	COG2233	PERMEase
CVS42_09345	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_09350	COG2252	PERMEase
CVS42_09355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CVS42_09360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CVS42_09365	COG2080	2 iron, 2 sulfur cluster binding
CVS42_09370	COG3134	Outer membrane lipoprotein
CVS42_09380	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_09385	COG3706	GGDEF domain
CVS42_09400	COG0107	imidazoleglycerol-phosphate synthase activity
CVS42_09405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CVS42_09410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CVS42_09415	COG0131	Imidazoleglycerol-phosphate dehydratase
CVS42_09415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS42_09420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CVS42_09425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CVS42_09430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CVS42_09440	COG1199	ATP-dependent helicase activity
CVS42_09445	COG1214	PFAM Peptidase M22, glycoprotease
CVS42_09455	COG2267	carboxylic ester hydrolase activity
CVS42_09460	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_09475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CVS42_09480	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CVS42_09485	COG0709	Synthesizes selenophosphate from selenide and ATP
CVS42_09515	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVS42_09520	COG0840	transmembrane signaling receptor activity
CVS42_09525	COG1254	Belongs to the acylphosphatase family
CVS42_09535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_09535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_09540	COG0489	protein tyrosine kinase activity
CVS42_09545	COG0572	uridine kinase
CVS42_09550	COG0717	Belongs to the dCTP deaminase family
CVS42_09555	COG0306	phosphate transporter
CVS42_09560	COG3313	Fe-S protein
CVS42_09565	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CVS42_09570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_09575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS42_09580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CVS42_09590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CVS42_09600	COG0366	Alpha amylase catalytic
CVS42_09615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CVS42_09620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CVS42_09625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CVS42_09630	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CVS42_09635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CVS42_09640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_09640	COG0072	phenylalanine-tRNA ligase activity
CVS42_09645	COG0776	regulation of translation
CVS42_09650	COG2205	protein histidine kinase activity
CVS42_09650	COG0784	Response regulator, receiver
CVS42_09665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS42_09675	COG5001	Diguanylate cyclase
CVS42_09675	COG3300	MHYT domain
CVS42_09680	COG1609	Transcriptional regulator
CVS42_09685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_09690	COG1879	ABC-type sugar transport system periplasmic component
CVS42_09695	COG1172	Belongs to the binding-protein-dependent transport system permease family
CVS42_09700	COG1129	ABC transporter
CVS42_09705	COG1869	D-ribose catabolic process
CVS42_09710	COG0625	glutathione transferase activity
CVS42_09720	COG5654	RES domain protein
CVS42_09730	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CVS42_09735	COG1177	transmembrane transport
CVS42_09740	COG1176	ABC-type spermidine putrescine transport system, permease component I
CVS42_09760	COG0037	tRNA processing
CVS42_09765	COG0589	response to stress
CVS42_09770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CVS42_09785	COG2217	Heavy metal translocating P-type atpase
CVS42_09795	COG2010	Cytochrome c
CVS42_09810	COG3278	Belongs to the heme-copper respiratory oxidase family
CVS42_09820	COG1956	GAF domain-containing protein
CVS42_09825	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CVS42_09835	COG0308	aminopeptidase N
CVS42_09845	COG2902	Dehydrogenase
CVS42_09850	COG0167	dihydroorotate dehydrogenase activity
CVS42_09865	COG0254	rRNA binding
CVS42_09870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CVS42_09875	COG0116	Belongs to the methyltransferase superfamily
CVS42_09875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CVS42_09895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS42_09900	COG1067	ATP-dependent peptidase activity
CVS42_09985	COG3141	response to X-ray
CVS42_09990	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CVS42_09995	COG4221	oxidoreductase activity
CVS42_10040	COG0372	Belongs to the citrate synthase family
CVS42_10045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CVS42_10055	COG2995	paraquat-inducible protein a
CVS42_10060	COG3008	intermembrane lipid transfer
CVS42_10065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_10065	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CVS42_10080	COG0084	hydrolase, TatD family'
CVS42_10085	COG0470	DNA polymerase III
CVS42_10090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CVS42_10095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CVS42_10100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS42_10105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CVS42_10110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CVS42_10115	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_10125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CVS42_10130	COG0416	fatty acid biosynthetic process
CVS42_10135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CVS42_10140	COG1399	metal-binding, possibly nucleic acid-binding protein
CVS42_10145	COG0424	maF-like protein
CVS42_10160	COG1530	ribonuclease E activity
CVS42_10170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CVS42_10170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_10170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CVS42_10175	COG1105	Belongs to the carbohydrate kinase PfkB family
CVS42_10180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_10180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_10185	COG1609	Transcriptional regulator
CVS42_10190	COG0814	amino acid
CVS42_10200	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CVS42_10215	COG0513	Belongs to the DEAD box helicase family
CVS42_10225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CVS42_10230	COG2890	protein-(glutamine-N5) methyltransferase activity
CVS42_10235	COG2840	Smr protein MutS2
CVS42_10240	COG3706	GGDEF domain
CVS42_10245	COG0406	alpha-ribazole phosphatase activity
CVS42_10270	COG2824	Alkylphosphonate utilization operon protein PhnA
CVS42_10290	COG0814	amino acid
CVS42_10295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CVS42_10305	COG0514	ATP-dependent DNA helicase (RecQ)
CVS42_10310	COG2766	serine protein kinase
CVS42_10315	COG2718	Belongs to the UPF0229 family
CVS42_10320	COG2719	SpoVR family
CVS42_10325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS42_10325	COG1024	Enoyl-CoA hydratase
CVS42_10330	COG0183	Belongs to the thiolase family
CVS42_10335	COG0714	Associated with various cellular activities
CVS42_10355	COG2304	oxidoreductase activity
CVS42_10365	COG1595	DNA-templated transcription, initiation
CVS42_10375	COG2067	long-chain fatty acid transport protein
CVS42_10380	COG2067	long-chain fatty acid transport protein
CVS42_10385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CVS42_10400	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CVS42_10410	COG1643	Atp-dependent helicase
CVS42_10420	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_10425	COG3119	arylsulfatase activity
CVS42_10430	COG0714	Associated with various cellular activities
CVS42_10445	COG2304	oxidoreductase activity
CVS42_10450	COG2304	oxidoreductase activity
CVS42_10475	COG0641	radical SAM
CVS42_10480	COG2925	Exonuclease
CVS42_10490	COG3345	alpha-galactosidase
CVS42_10495	COG1380	Effector of murein hydrolase LrgA
CVS42_10500	COG1346	cytolysis
CVS42_10505	COG0295	cytidine deaminase activity
CVS42_10510	COG3033	Beta-eliminating lyase
CVS42_10520	COG3046	protein related to deoxyribodipyrimidine photolyase
CVS42_10525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_10530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CVS42_10555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_10570	COG0454	-acetyltransferase
CVS42_10580	COG3158	transport of potassium into the cell
CVS42_10585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CVS42_10590	COG0651	ATP synthesis coupled electron transport
CVS42_10595	COG0650	Formate hydrogenlyase subunit 4
CVS42_10600	COG3261	NADH dehydrogenase
CVS42_10600	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CVS42_10605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_10610	COG3260	NADH ubiquinone oxidoreductase 20
CVS42_10620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS42_10625	COG1921	L-seryl-tRNASec selenium transferase activity
CVS42_10635	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CVS42_10640	COG0298	carbon dioxide binding
CVS42_10650	COG0309	Hydrogenase expression formation protein (HypE)
CVS42_10655	COG0375	protein maturation
CVS42_10660	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CVS42_10665	COG1124	(ABC) transporter
CVS42_10675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_10680	COG0601	transmembrane transport
CVS42_10685	COG0747	negative chemotaxis
CVS42_10690	COG1773	rubredoxin
CVS42_10695	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CVS42_10700	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CVS42_10705	COG5557	Pfam Polysulphide reductase, NrfD
CVS42_10710	COG0437	4 iron, 4 sulfur cluster binding
CVS42_10715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CVS42_10720	COG5001	Diguanylate cyclase
CVS42_10720	COG4251	negative regulation of phosphorylation
CVS42_10720	COG3706	GGDEF domain
CVS42_10720	COG2203	Gaf domain
CVS42_10725	COG0438	transferase activity, transferring glycosyl groups
CVS42_10730	COG0438	transferase activity, transferring glycosyl groups
CVS42_10750	COG0438	transferase activity, transferring glycosyl groups
CVS42_10795	COG0438	transferase activity, transferring glycosyl groups
CVS42_10800	COG1215	transferase activity, transferring glycosyl groups
CVS42_10805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS42_10845	COG2205	protein histidine kinase activity
CVS42_10845	COG0784	Response regulator, receiver
CVS42_10860	COG0730	response to heat
CVS42_10875	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_10885	COG1024	Enoyl-CoA hydratase
CVS42_10890	COG1024	Enoyl-CoA hydratase
CVS42_10895	COG1960	acyl-CoA dehydrogenase activity
CVS42_10900	COG1960	acyl-CoA dehydrogenase activity
CVS42_10905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CVS42_10910	COG1024	Enoyl-CoA hydratase
CVS42_10940	COG1584	GPR1 FUN34 yaaH family protein
CVS42_10970	COG1115	amino acid carrier protein
CVS42_10975	COG4974	Belongs to the 'phage' integrase family
CVS42_11000	COG1024	Enoyl-CoA hydratase
CVS42_11015	COG3162	membrane
CVS42_11020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CVS42_11085	COG4584	PFAM Integrase catalytic
CVS42_11090	COG1484	DNA-dependent DNA replication
CVS42_11100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS42_11220	COG1484	DNA-dependent DNA replication
CVS42_11225	COG4584	PFAM Integrase catalytic
CVS42_11385	COG0582	viral genome integration into host DNA
CVS42_11390	COG0488	(ABC) transporter
CVS42_11395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_11400	COG0776	regulation of translation
CVS42_11405	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CVS42_11410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CVS42_11415	COG0740	serine-type endopeptidase activity
CVS42_11420	COG0544	peptidyl-prolyl cis-trans isomerase activity
CVS42_11435	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CVS42_11440	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS42_11445	COG1136	(ABC) transporter
CVS42_11450	COG4591	ABC-type transport system involved in lipoprotein release permease component
CVS42_11460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CVS42_11465	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CVS42_11470	COG4166	transmembrane transport
CVS42_11475	COG0697	spore germination
CVS42_11485	COG2062	phosphohistidine phosphatase, SixA
CVS42_11490	COG1025	Belongs to the peptidase M16 family
CVS42_11525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS42_11525	COG0519	Catalyzes the synthesis of GMP from XMP
CVS42_11530	COG0516	GMP reductase activity
CVS42_11530	COG0517	IMP dehydrogenase activity
CVS42_11540	COG1570	exodeoxyribonuclease VII activity
CVS42_11550	COG1181	Belongs to the D-alanine--D-alanine ligase family
CVS42_11560	COG0386	Belongs to the glutathione peroxidase family
CVS42_11565	COG0513	Belongs to the DEAD box helicase family
CVS42_11580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_11585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CVS42_11590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CVS42_11610	COG0598	Magnesium transport protein CorA
CVS42_11640	COG5001	Diguanylate cyclase
CVS42_11640	COG3300	MHYT domain
CVS42_11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_11665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CVS42_11670	COG0563	adenylate kinase activity
CVS42_11680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CVS42_11685	COG1286	toxin biosynthetic process
CVS42_11690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CVS42_11695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CVS42_11700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CVS42_11705	COG1674	ftsk spoiiie
CVS42_11705	COG0531	amino acid
CVS42_11715	COG0686	Belongs to the AlaDH PNT family
CVS42_11720	COG0492	ferredoxin-NADP+ reductase activity
CVS42_11725	COG3706	GGDEF domain
CVS42_11730	COG3134	Outer membrane lipoprotein
CVS42_11735	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CVS42_11740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CVS42_11745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CVS42_11750	COG0542	response to heat
CVS42_11755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CVS42_11760	COG1278	Cold shock
CVS42_11765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CVS42_11785	COG0745	RESPONSE REGULATOR receiver
CVS42_11790	COG2205	protein histidine kinase activity
CVS42_11800	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CVS42_11800	COG0392	lysyltransferase activity
CVS42_11840	COG1435	thymidine kinase activity
CVS42_11845	COG1757	Na H antiporter
CVS42_11850	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_11855	COG2096	Adenosyltransferase
CVS42_11860	COG3530	Putative quorum-sensing-regulated virulence factor
CVS42_11865	COG0602	queuosine metabolic process
CVS42_11870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CVS42_11890	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CVS42_11900	COG0776	regulation of translation
CVS42_11905	COG0539	negative regulation of cytoplasmic translation
CVS42_11910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CVS42_11915	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CVS42_11930	COG2814	Major facilitator Superfamily
CVS42_11950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CVS42_11955	COG3300	MHYT domain
CVS42_11955	COG5001	Diguanylate cyclase
CVS42_11960	COG0583	DNA-binding transcription factor activity
CVS42_11965	COG3437	response regulator, receiver
CVS42_11990	COG4989	oxidoreductase activity
CVS42_11995	COG0724	RNA recognition motif
CVS42_12005	COG1126	abc transporter atp-binding protein
CVS42_12010	COG0765	amino acid transport
CVS42_12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_12020	COG4597	amino acid ABC transporter
CVS42_12025	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CVS42_12035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CVS42_12060	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CVS42_12070	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_12075	COG1360	Flagellar Motor Protein
CVS42_12080	COG4771	TonB-dependent receptor
CVS42_12085	COG1770	oligopeptidase
CVS42_12105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_12110	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_12115	COG0649	NAD binding
CVS42_12115	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_12130	COG1034	ATP synthesis coupled electron transport
CVS42_12135	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CVS42_12140	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_12145	COG0839	Belongs to the complex I subunit 6 family
CVS42_12150	COG0713	ATP synthesis coupled electron transport
CVS42_12160	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CVS42_12165	COG1007	ATP synthesis coupled electron transport
CVS42_12180	COG2199	diguanylate cyclase activity
CVS42_12180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_12185	COG3300	MHYT domain
CVS42_12185	COG5001	Diguanylate cyclase
CVS42_12230	COG1242	4 iron, 4 sulfur cluster binding
CVS42_12235	COG0069	glutamate synthase activity
CVS42_12235	COG0067	glutamate synthase
CVS42_12235	COG0070	glutamate synthase
CVS42_12240	COG0493	'glutamate synthase
CVS42_12255	COG0513	Belongs to the DEAD box helicase family
CVS42_12280	COG0023	Translation Initiation Factor
CVS42_12285	COG2119	membrane
CVS42_12325	COG1061	Type III restriction enzyme res subunit
CVS42_12330	COG0215	cysteine-tRNA ligase activity
CVS42_12335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS42_12345	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_12350	COG2261	transglycosylase associated protein
CVS42_12355	COG0642	Histidine kinase
CVS42_12385	COG0582	viral genome integration into host DNA
CVS42_12410	COG0322	excinuclease ABC activity
CVS42_12415	COG2197	response regulator
CVS42_12420	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CVS42_12425	COG2835	tetraacyldisaccharide 4'-kinase activity
CVS42_12430	COG1663	tetraacyldisaccharide 4'-kinase activity
CVS42_12440	COG0658	competence protein
CVS42_12440	COG2333	competence protein COMEC
CVS42_12455	COG1448	Aminotransferase
CVS42_12465	COG0583	DNA-binding transcription factor activity
CVS42_12470	COG3085	chromosome segregation
CVS42_12475	COG4574	serine-type endopeptidase inhibitor activity
CVS42_12480	COG0584	glycerophosphoryl diester phosphodiesterase
CVS42_12490	COG1349	DNA-binding transcription factor activity
CVS42_12495	COG2271	Major facilitator Superfamily
CVS42_12500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CVS42_12505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CVS42_12510	COG0840	transmembrane signaling receptor activity
CVS42_12525	COG0583	DNA-binding transcription factor activity
CVS42_12550	COG0656	L-ascorbic acid biosynthetic process
CVS42_12560	COG2814	Major facilitator Superfamily
CVS42_12565	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS42_12580	COG3220	belongs to the UPF0276 family
CVS42_12600	COG1294	oxidase, subunit
CVS42_12610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CVS42_12620	COG2979	Protein of unknown function (DUF533)
CVS42_12625	COG1607	acyl-coa hydrolase
CVS42_12635	COG0583	DNA-binding transcription factor activity
CVS42_12640	COG2807	transmembrane transport
CVS42_12645	COG1187	pseudouridine synthase activity
CVS42_12655	COG0346	lactoylglutathione lyase activity
CVS42_12665	COG1403	HNH endonuclease
CVS42_12670	COG4657	Part of a membrane complex involved in electron transport
CVS42_12675	COG2878	Part of a membrane complex involved in electron transport
CVS42_12685	COG4658	electron transport chain
CVS42_12690	COG4659	FMN binding
CVS42_12700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CVS42_12705	COG0346	lactoylglutathione lyase activity
CVS42_12740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CVS42_12745	COG0505	Belongs to the CarA family
CVS42_12750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CVS42_12765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CVS42_12770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CVS42_12775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CVS42_12780	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CVS42_12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_12790	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CVS42_12820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CVS42_12825	COG0861	Integral membrane protein TerC family
CVS42_12835	COG0444	Belongs to the ABC transporter superfamily
CVS42_12840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CVS42_12845	COG0601	transmembrane transport
CVS42_12855	COG2095	MarC family integral membrane protein
CVS42_12860	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_12860	COG1454	alcohol dehydrogenase
CVS42_12865	COG0217	transcriptional regulatory protein
CVS42_12870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CVS42_12880	COG1801	Protein of unknown function DUF72
CVS42_12885	COG4106	trans-aconitate 2-methyltransferase activity
CVS42_12890	COG0500	methyltransferase
CVS42_12930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CVS42_12945	COG1086	Polysaccharide biosynthesis protein
CVS42_12950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS42_12965	COG0367	asparagine synthase
CVS42_12970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CVS42_12980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CVS42_13000	COG2226	methyltransferase
CVS42_13015	COG0438	transferase activity, transferring glycosyl groups
CVS42_13025	COG0562	UDP-galactopyranose mutase
CVS42_13030	COG1215	transferase activity, transferring glycosyl groups
CVS42_13045	COG0318	PFAM AMP-dependent synthetase and ligase
CVS42_13065	COG1083	cytidylyl-transferase
CVS42_13075	COG2089	acid synthase
CVS42_13095	COG4310	Domain of unknown function (DUF2172)
CVS42_13150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_13165	COG0301	tRNA thio-modification
CVS42_13165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_13180	COG4953	penicillin-binding protein 1C
CVS42_13185	COG2373	Large extracellular alpha-helical protein
CVS42_13195	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_13200	COG5001	Diguanylate cyclase
CVS42_13200	COG3300	MHYT domain
CVS42_13205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_13215	COG1252	NADH dehydrogenase
CVS42_13225	COG2233	PERMEase
CVS42_13235	COG2354	Protein conserved in bacteria
CVS42_13245	COG0840	transmembrane signaling receptor activity
CVS42_13250	COG1301	dicarboxylic acid transport
CVS42_13265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CVS42_13280	COG0537	adenosine 5'-monophosphoramidase activity
CVS42_13315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_13320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CVS42_13330	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_13335	COG0287	Prephenate dehydrogenase
CVS42_13335	COG1605	Chorismate mutase
CVS42_13345	COG1199	ATP-dependent helicase activity
CVS42_13355	COG0123	including yeast histone deacetylase and acetoin utilization protein
CVS42_13360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CVS42_13365	COG1785	Belongs to the alkaline phosphatase family
CVS42_13385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS42_13390	COG2197	response regulator
CVS42_13400	COG2271	Major facilitator Superfamily
CVS42_13405	COG3300	MHYT domain
CVS42_13405	COG5001	Diguanylate cyclase
CVS42_13410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_13415	COG0765	amino acid transport
CVS42_13420	COG1126	abc transporter atp-binding protein
CVS42_13435	COG0531	amino acid
CVS42_13450	COG1253	flavin adenine dinucleotide binding
CVS42_13455	COG0704	Plays a role in the regulation of phosphate uptake
CVS42_13465	COG0581	inorganic phosphate transmembrane transporter activity
CVS42_13470	COG0573	inorganic phosphate transmembrane transporter activity
CVS42_13475	COG0590	tRNA wobble adenosine to inosine editing
CVS42_13485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CVS42_13505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CVS42_13510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CVS42_13515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CVS42_13520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CVS42_13525	COG2204	response regulator
CVS42_13530	COG3852	Histidine kinase
CVS42_13535	COG2204	response regulator
CVS42_13545	COG2716	regulation of RNA biosynthetic process
CVS42_13550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CVS42_13555	COG0248	Ppx GppA phosphatase
CVS42_13560	COG2239	Acts as a magnesium transporter
CVS42_13565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_13575	COG1705	Flagellar rod assembly protein muramidase FlgJ
CVS42_13575	COG3951	Flagellar rod assembly protein muramidase FlgJ
CVS42_13580	COG1706	bacterial-type flagellum-dependent cell motility
CVS42_13585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS42_13590	COG4786	Flagellar basal body rod
CVS42_13595	COG4787	bacterial-type flagellum-dependent cell motility
CVS42_13605	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS42_13610	COG1558	bacterial-type flagellum-dependent cell motility
CVS42_13615	COG1815	bacterial-type flagellum-dependent cell motility
CVS42_13620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CVS42_13625	COG0835	chemotaxis
CVS42_13625	COG0784	Response regulator, receiver
CVS42_13630	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CVS42_13645	COG0622	Phosphoesterase
CVS42_13650	COG4166	transmembrane transport
CVS42_13660	COG1187	pseudouridine synthase activity
CVS42_13665	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_13675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS42_13680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_13690	COG1349	DNA-binding transcription factor activity
CVS42_13695	COG4166	transmembrane transport
CVS42_13720	COG1278	Cold shock
CVS42_13745	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CVS42_13745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CVS42_13750	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_13755	COG1535	isochorismatase
CVS42_13755	COG3433	isochorismatase activity
CVS42_13760	COG1021	2,3-dihydroxybenzoate-AMP ligase
CVS42_13765	COG1169	isochorismate synthase
CVS42_13770	COG4771	TonB-dependent receptor
CVS42_13775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CVS42_13780	COG1609	Transcriptional regulator
CVS42_13785	COG0741	lytic transglycosylase activity
CVS42_13795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CVS42_13815	COG2911	Protein conserved in bacteria
CVS42_13820	COG0729	surface antigen
CVS42_13830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_13845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CVS42_13855	COG4134	Bacterial extracellular solute-binding protein
CVS42_13865	COG4136	ATPase activity
CVS42_13870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CVS42_13875	COG2951	lytic endotransglycosylase activity
CVS42_13880	COG1846	Transcriptional regulator
CVS42_13890	COG0033	Phosphoglucomutase
CVS42_13895	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CVS42_13900	COG0596	Alpha beta hydrolase
CVS42_13915	COG0716	FMN binding
CVS42_13925	COG0735	belongs to the Fur family
CVS42_13930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_13940	COG1263	PTS System
CVS42_13940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_13940	COG2190	(PTS) system
CVS42_13945	COG0363	glucosamine-6-phosphate deaminase activity
CVS42_13950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CVS42_13955	COG1940	carbohydrate kinase activity
CVS42_13955	COG1846	Transcriptional regulator
CVS42_13965	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CVS42_13965	COG2199	diguanylate cyclase activity
CVS42_13970	COG3275	phosphorelay sensor kinase activity
CVS42_13975	COG3279	Response regulator of the LytR AlgR family
CVS42_13980	COG1966	Carbon starvation protein
CVS42_13990	COG1566	PFAM secretion protein HlyD family protein
CVS42_13995	COG1061	Type III restriction enzyme res subunit
CVS42_14000	COG2027	D-alanyl-D-alanine carboxypeptidase
CVS42_14005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CVS42_14010	COG3021	interspecies interaction between organisms
CVS42_14020	COG1607	acyl-coa hydrolase
CVS42_14025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CVS42_14035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CVS42_14035	COG1013	pyruvate-flavodoxin oxidoreductase activity
CVS42_14035	COG0674	pyruvate-flavodoxin oxidoreductase activity
CVS42_14035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CVS42_14050	COG3217	Mosc domain protein beta barrel domain protein
CVS42_14050	COG0633	Ferredoxin
CVS42_14050	COG0633	Ferredoxin
CVS42_14050	COG3217	Mosc domain protein beta barrel domain protein
CVS42_14060	COG0501	Belongs to the peptidase M48B family
CVS42_14065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CVS42_14070	COG1073	alpha beta
CVS42_14070	COG2226	methyltransferase
CVS42_14075	COG0156	8-amino-7-oxononanoate synthase activity
CVS42_14080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS42_14085	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CVS42_14100	COG0017	Asparaginyl-tRNA synthetase
CVS42_14110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS42_14120	COG1473	amidohydrolase
CVS42_14125	COG3069	C4-dicarboxylate transmembrane transporter activity
CVS42_14135	COG1393	Belongs to the ArsC family
CVS42_14140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CVS42_14145	COG1876	peptidase activity
CVS42_14155	COG3263	regulation of cellular component size
CVS42_14165	COG3263	regulation of cellular component size
CVS42_14170	COG1280	lysine exporter protein (LysE YggA)
CVS42_14200	COG0564	pseudouridine synthase activity
CVS42_14210	COG1454	alcohol dehydrogenase
CVS42_14215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_14220	COG0702	epimerase
CVS42_14230	COG0095	Lipoate-protein ligase
CVS42_14240	COG1136	(ABC) transporter
CVS42_14240	COG0577	efflux transmembrane transporter activity
CVS42_14245	COG1136	(ABC) transporter
CVS42_14245	COG0577	efflux transmembrane transporter activity
CVS42_14250	COG1136	(ABC) transporter
CVS42_14250	COG0577	efflux transmembrane transporter activity
CVS42_14255	COG1566	PFAM secretion protein HlyD family protein
CVS42_14270	COG2391	methyltransferase activity
CVS42_14290	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_14300	COG1285	pathogenesis
CVS42_14330	COG0484	heat shock protein binding
CVS42_14335	COG0443	Heat shock 70 kDa protein
CVS42_14340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CVS42_14345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CVS42_14350	COG0497	DNA recombination
CVS42_14355	COG1227	inorganic diphosphatase activity
CVS42_14360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_14365	COG1136	(ABC) transporter
CVS42_14365	COG0577	efflux transmembrane transporter activity
CVS42_14370	COG1538	Outer membrane efflux protein
CVS42_14385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CVS42_14395	COG0297	glycogen (starch) synthase activity
CVS42_14400	COG0463	Glycosyl transferase, family 2
CVS42_14400	COG1216	Glycosyl transferase, family 2
CVS42_14415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS42_14430	COG0529	Catalyzes the synthesis of activated sulfate
CVS42_14435	COG0490	domain, Protein
CVS42_14435	COG0471	metal ion transport
CVS42_14440	COG2895	sulfate adenylyltransferase (ATP) activity
CVS42_14450	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS42_14455	COG0463	Glycosyl transferase, family 2
CVS42_14485	COG1450	Type ii and iii secretion system protein
CVS42_14535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_14555	COG1091	dTDP-4-dehydrorhamnose reductase activity
CVS42_14570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CVS42_14575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_14580	COG1309	transcriptional regulator
CVS42_14595	COG1342	Belongs to the UPF0251 family
CVS42_14615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CVS42_14630	COG1943	Transposase
CVS42_14645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CVS42_14650	COG0083	homoserine kinase activity
CVS42_14660	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CVS42_14665	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CVS42_14670	COG1946	Acyl-CoA thioesterase
CVS42_14680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CVS42_14690	COG0009	L-threonylcarbamoyladenylate synthase
CVS42_14700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CVS42_14705	COG0512	Glutamine amidotransferase of anthranilate synthase
CVS42_14705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS42_14710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CVS42_14715	COG0135	phosphoribosylanthranilate isomerase activity
CVS42_14715	COG0134	indole-3-glycerol-phosphate synthase activity
CVS42_14720	COG0133	tryptophan synthase activity
CVS42_14725	COG0159	tryptophan synthase activity
CVS42_14740	COG1988	membrane-bound metal-dependent
CVS42_14760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_14770	COG0798	PFAM Bile acid sodium symporter
CVS42_14800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CVS42_14810	COG0745	RESPONSE REGULATOR receiver
CVS42_14825	COG4988	ABC transporter
CVS42_14830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CVS42_14850	COG1720	tRNA m6t6A37 methyltransferase activity
CVS42_14855	COG3038	cytochrome b561
CVS42_14865	COG0745	RESPONSE REGULATOR receiver
CVS42_14875	COG2862	Uncharacterized protein family, UPF0114
CVS42_14890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CVS42_14895	COG1917	Cupin 2, conserved barrel domain protein
CVS42_14895	COG1396	sequence-specific DNA binding
CVS42_14910	COG0531	amino acid
CVS42_14920	COG0531	amino acid
CVS42_14925	COG1283	sodium-dependent phosphate transmembrane transporter activity
CVS42_14935	COG0405	Gamma-glutamyltransferase
CVS42_14940	COG2974	May be involved in recombination
CVS42_14950	COG0420	3'-5' exonuclease activity
CVS42_14955	COG0419	ATPase involved in DNA repair
CVS42_14960	COG3384	dioxygenase
CVS42_14970	COG0469	pyruvate kinase activity
CVS42_14975	COG3264	Mechanosensitive ion channel
CVS42_14975	COG1196	nuclear chromosome segregation
CVS42_14985	COG3590	peptidase
CVS42_14990	COG3706	GGDEF domain
CVS42_14995	COG2190	(PTS) system
CVS42_15005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_15010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CVS42_15015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS42_15030	COG2770	Histidine kinase
CVS42_15030	COG3437	response regulator, receiver
CVS42_15035	COG3409	Peptidoglycan-binding domain 1 protein
CVS42_15035	COG3267	Type II secretory pathway component ExeA
CVS42_15045	COG3031	protein transport across the cell outer membrane
CVS42_15055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_15060	COG1459	type II secretion system
CVS42_15065	COG2165	general secretion pathway protein
CVS42_15075	COG2165	general secretion pathway protein
CVS42_15080	COG4795	General secretion pathway protein
CVS42_15085	COG3156	type II secretion system protein K
CVS42_15095	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CVS42_15105	COG0582	viral genome integration into host DNA
CVS42_15175	COG3501	Rhs element vgr protein
CVS42_15190	COG2916	Histone family protein nucleoid-structuring protein H-NS
CVS42_15200	COG4983	Phage plasmid primase, P4 family domain protein
CVS42_15250	COG2003	Belongs to the UPF0758 family
CVS42_15300	COG2003	Belongs to the UPF0758 family
CVS42_15315	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CVS42_15325	COG0670	Belongs to the BI1 family
CVS42_15330	COG1289	transmembrane transporter activity
CVS42_15335	COG2920	part of a sulfur-relay system
CVS42_15340	COG0673	inositol 2-dehydrogenase activity
CVS42_15345	COG0583	DNA-binding transcription factor activity
CVS42_15395	COG1032	radical SAM domain protein
CVS42_15405	COG1566	PFAM secretion protein HlyD family protein
CVS42_15410	COG3706	GGDEF domain
CVS42_15415	COG1752	Esterase of the alpha-beta hydrolase superfamily
CVS42_15420	COG0531	amino acid
CVS42_15445	COG0281	malic enzyme
CVS42_15455	COG0534	Mate efflux family protein
CVS42_15465	COG3706	GGDEF domain
CVS42_15470	COG2233	PERMEase
CVS42_15475	COG0095	Lipoate-protein ligase
CVS42_15480	COG1115	amino acid carrier protein
CVS42_15485	COG0019	diaminopimelate decarboxylase activity
CVS42_15495	COG0678	peroxiredoxin activity
CVS42_15520	COG0545	Peptidyl-prolyl cis-trans isomerase
CVS42_15525	COG3142	Participates in the control of copper homeostasis
CVS42_15540	COG4783	chaperone-mediated protein folding
CVS42_15550	COG5002	protein histidine kinase activity
CVS42_15555	COG0745	RESPONSE REGULATOR receiver
CVS42_15560	COG0346	lactoylglutathione lyase activity
CVS42_15565	COG3284	Transcriptional regulator
CVS42_15570	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_15580	COG0697	spore germination
CVS42_15585	COG4565	transcriptional regulatory protein
CVS42_15590	COG3290	protein histidine kinase activity
CVS42_15595	COG0281	malic enzyme
CVS42_15615	COG1846	Transcriptional regulator
CVS42_15620	COG1566	PFAM secretion protein HlyD family protein
CVS42_15650	COG0602	queuosine metabolic process
CVS42_15655	COG1328	CTP reductase activity
CVS42_15665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CVS42_15670	COG3115	cell septum assembly
CVS42_15675	COG1196	nuclear chromosome segregation
CVS42_15685	COG2860	membrane
CVS42_15695	COG3108	Peptidase M15
CVS42_15700	COG2989	Protein conserved in bacteria
CVS42_15715	COG0463	Glycosyl transferase, family 2
CVS42_15730	COG0366	Alpha amylase catalytic
CVS42_15765	COG2199	diguanylate cyclase activity
CVS42_15765	COG2203	Gaf domain
CVS42_15775	COG3590	peptidase
CVS42_15785	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CVS42_15790	COG1982	Orn Lys Arg decarboxylase major
CVS42_15795	COG0531	amino acid
CVS42_15800	COG3710	Transcriptional regulator
CVS42_15810	COG0531	amino acid
CVS42_15830	COG0814	amino acid
CVS42_15860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CVS42_15865	COG0739	heme binding
CVS42_15870	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CVS42_15880	COG0251	oxidation-reduction process
CVS42_15895	COG0583	DNA-binding transcription factor activity
CVS42_15910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CVS42_15920	COG3091	SprT-like family
CVS42_15930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CVS42_15935	COG0189	ligase activity
CVS42_15940	COG1678	Uncharacterized ACR, COG1678
CVS42_15945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CVS42_15950	COG3104	oligopeptide transport
CVS42_15955	COG0583	DNA-binding transcription factor activity
CVS42_15965	COG0714	Associated with various cellular activities
CVS42_15980	COG1115	amino acid carrier protein
CVS42_15985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CVS42_15995	COG0825	malonyl-CoA metabolic process
CVS42_16005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CVS42_16010	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_16015	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_16020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CVS42_16025	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CVS42_16040	COG0750	zinc metalloprotease
CVS42_16045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CVS42_16050	COG0575	Belongs to the CDS family
CVS42_16060	COG0233	cytoplasmic translational termination
CVS42_16065	COG0528	UMP kinase activity
CVS42_16070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CVS42_16075	COG0052	Belongs to the universal ribosomal protein uS2 family
CVS42_16080	COG0024	Methionine aminopeptidase
CVS42_16085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CVS42_16090	COG2171	N-acyltransferase activity
CVS42_16100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_16100	COG1263	PTS System
CVS42_16120	COG0564	pseudouridine synthase activity
CVS42_16125	COG3098	single-species biofilm formation
CVS42_16150	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CVS42_16160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS42_16160	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CVS42_16170	COG3706	GGDEF domain
CVS42_16175	COG1611	Belongs to the LOG family
CVS42_16180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_16185	COG0473	3-isopropylmalate dehydrogenase activity
CVS42_16195	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CVS42_16200	COG2363	Small membrane protein
CVS42_16210	COG0583	DNA-binding transcription factor activity
CVS42_16215	COG0840	transmembrane signaling receptor activity
CVS42_16220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CVS42_16235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CVS42_16240	COG1666	GTP binding
CVS42_16250	COG2211	Major facilitator Superfamily
CVS42_16255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CVS42_16265	COG2813	Specifically methylates the guanine in position
CVS42_16270	COG0271	Belongs to the BolA IbaG family
CVS42_16275	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_16280	COG1805	sodium ion transport
CVS42_16290	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_16295	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CVS42_16300	COG2871	sodium ion transport
CVS42_16305	COG1477	protein flavinylation
CVS42_16335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CVS42_16350	COG0300	oxidoreductase activity
CVS42_16360	COG0415	Belongs to the DNA photolyase family
CVS42_16365	COG0789	Transcriptional regulator
CVS42_16370	COG3272	Protein of unknown function (DUF1722)
CVS42_16400	COG0077	Prephenate dehydratase
CVS42_16400	COG1605	Chorismate mutase
CVS42_16450	COG0697	spore germination
CVS42_16455	COG0840	transmembrane signaling receptor activity
CVS42_16465	COG0300	oxidoreductase activity
CVS42_16490	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CVS42_16530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CVS42_16535	COG0826	peptidase U32
CVS42_16540	COG1280	lysine exporter protein (LysE YggA)
CVS42_16570	COG2198	Histidine kinase
CVS42_16570	COG0643	Histidine kinase
CVS42_16580	COG0835	chemotaxis
CVS42_16585	COG0840	transmembrane signaling receptor activity
CVS42_16595	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CVS42_16600	COG2201	protein-glutamate methylesterase activity
CVS42_16605	COG1185	polyribonucleotide nucleotidyltransferase activity
CVS42_16610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CVS42_16615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CVS42_16620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CVS42_16625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CVS42_16630	COG0195	Participates in both transcription termination and antitermination
CVS42_16635	COG0779	Required for maturation of 30S ribosomal subunits
CVS42_16650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS42_16655	COG0149	triose-phosphate isomerase activity
CVS42_16660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CVS42_16665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CVS42_16670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CVS42_16675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CVS42_16680	COG1534	Rna-binding protein
CVS42_16690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CVS42_16695	COG1360	Flagellar Motor Protein
CVS42_16700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_16705	COG1722	exodeoxyribonuclease VII activity
CVS42_16710	COG0142	geranyltranstransferase activity
CVS42_16715	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CVS42_16740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CVS42_16745	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CVS42_16750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_16755	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CVS42_16775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS42_16775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CVS42_16780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CVS42_16790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CVS42_16800	COG2205	protein histidine kinase activity
CVS42_16800	COG2198	Histidine kinase
CVS42_16800	COG0784	Response regulator, receiver
CVS42_16805	COG1879	ABC-type sugar transport system periplasmic component
CVS42_16815	COG0745	RESPONSE REGULATOR receiver
CVS42_16820	COG3005	denitrification pathway
CVS42_16830	COG3381	protein complex oligomerization
CVS42_16850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS42_16855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CVS42_16860	COG0511	ligase activity, forming carbon-carbon bonds
CVS42_16865	COG0439	Biotin carboxylase
CVS42_16875	COG4145	pantothenate transmembrane transporter activity
CVS42_16880	COG1263	PTS System
CVS42_16880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_16880	COG2190	(PTS) system
CVS42_16885	COG0583	DNA-binding transcription factor activity
CVS42_16890	COG0604	alcohol dehydrogenase
CVS42_16895	COG2264	protein methyltransferase activity
CVS42_16905	COG0778	Nitroreductase
CVS42_16910	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_16910	COG1902	pentaerythritol trinitrate reductase activity
CVS42_16915	COG0616	signal peptide processing
CVS42_16935	COG0848	biopolymer transport protein
CVS42_16940	COG0811	peptide transport
CVS42_16945	COG0811	peptide transport
CVS42_16960	COG4174	ABC transporter (Permease)
CVS42_16965	COG4239	(ABC) transporter, permease
CVS42_16975	COG0444	Belongs to the ABC transporter superfamily
CVS42_16980	COG4608	Belongs to the ABC transporter superfamily
CVS42_17000	COG3416	Protein conserved in bacteria
CVS42_17010	COG0741	lytic transglycosylase activity
CVS42_17025	COG0488	(ABC) transporter
CVS42_17035	COG2252	PERMEase
CVS42_17040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_17045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CVS42_17050	COG0840	transmembrane signaling receptor activity
CVS42_17060	COG1278	Cold shock
CVS42_17100	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CVS42_17105	COG1162	GTPase activity
CVS42_17110	COG0688	phosphatidylethanolamine metabolic process
CVS42_17115	COG4628	conserved protein (DUF2132)
CVS42_17130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CVS42_17150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CVS42_17160	COG2195	Cleaves the N-terminal amino acid of tripeptides
CVS42_17165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CVS42_17170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CVS42_17175	COG3178	'Phosphotransferase
CVS42_17180	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CVS42_17185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CVS42_17190	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CVS42_17195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CVS42_17205	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CVS42_17220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CVS42_17235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CVS42_17240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CVS42_17245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CVS42_17250	COG0142	geranyltranstransferase activity
CVS42_17255	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CVS42_17260	COG0330	HflC and HflK could
CVS42_17265	COG0330	HflC and HflK could
CVS42_17270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CVS42_17275	COG1923	regulation of RNA biosynthetic process
CVS42_17280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CVS42_17285	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CVS42_17295	COG0802	atpase or kinase
CVS42_17300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CVS42_17300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CVS42_17320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CVS42_17325	COG2011	ABC-type metal ion transport system permease component
CVS42_17330	COG1464	Belongs to the NlpA lipoprotein family
CVS42_17340	COG0840	transmembrane signaling receptor activity
CVS42_17355	COG0784	Response regulator, receiver
CVS42_17355	COG2198	Histidine kinase
CVS42_17355	COG5002	protein histidine kinase activity
CVS42_17390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CVS42_17395	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CVS42_17400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS42_17405	COG2716	regulation of RNA biosynthetic process
CVS42_17410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CVS42_17415	COG3013	Belongs to the UPF0304 family
CVS42_17420	COG3092	negative regulation of chromosome organization
CVS42_17425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CVS42_17430	COG0280	phosphate acetyltransferase
CVS42_17430	COG0857	belongs to the CobB CobQ family
CVS42_17435	COG1555	photosystem II stabilization
CVS42_17440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CVS42_17445	COG3104	oligopeptide transport
CVS42_17450	COG0745	RESPONSE REGULATOR receiver
CVS42_17480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CVS42_17495	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CVS42_17530	COG0440	acetolactate synthase activity
CVS42_17535	COG0028	Belongs to the TPP enzyme family
CVS42_17560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CVS42_17565	COG0473	3-isopropylmalate dehydrogenase activity
CVS42_17570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CVS42_17575	COG0066	3-isopropylmalate dehydratase activity
CVS42_17590	COG4143	(ABC) transporter
CVS42_17595	COG1178	ABC-type Fe3 transport system permease component
CVS42_17600	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CVS42_17605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CVS42_17655	COG0459	protein refolding
CVS42_17660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CVS42_17670	COG3030	protein affecting phage T7 exclusion by the F plasmid
CVS42_17675	COG1027	Aspartate ammonia-lyase
CVS42_17680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CVS42_17685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CVS42_17690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CVS42_17695	COG1610	YqeY-like protein
CVS42_17700	COG0358	DNA primase activity
CVS42_17705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CVS42_17745	COG0305	Participates in initiation and elongation during chromosome replication
CVS42_17775	COG0151	Belongs to the GarS family
CVS42_17780	COG0138	bifunctional purine biosynthesis protein purh
CVS42_17820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_17825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_17835	COG0583	DNA-binding transcription factor activity
CVS42_17840	COG0477	Major facilitator Superfamily
CVS42_17855	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_17860	COG3706	GGDEF domain
CVS42_17860	COG0745	RESPONSE REGULATOR receiver
CVS42_17865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CVS42_17880	COG0456	acetyltransferase
CVS42_17890	COG1022	Amp-dependent synthetase and ligase
CVS42_17900	COG2918	glutathione biosynthetic process
CVS42_17905	COG0612	Peptidase, M16
CVS42_17910	COG1238	metal cluster binding
CVS42_17940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_17945	COG0359	binds to the 23S rRNA
CVS42_17950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CVS42_17955	COG0360	Binds together with S18 to 16S ribosomal RNA
CVS42_17960	COG1914	H( )-stimulated, divalent metal cation uptake system
CVS42_17965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS42_17975	COG0776	regulation of translation
CVS42_17990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CVS42_18005	COG0560	Phosphoserine phosphatase
CVS42_18020	COG0813	purine-nucleoside phosphorylase activity
CVS42_18025	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CVS42_18030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CVS42_18035	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CVS42_18045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_18050	COG0084	hydrolase, TatD family'
CVS42_18065	COG1854	S-ribosylhomocysteine lyase activity
CVS42_18080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CVS42_18080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS42_18140	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CVS42_18145	COG1047	Peptidyl-prolyl cis-trans
CVS42_18150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CVS42_18155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CVS42_18160	COG0196	riboflavin kinase activity
CVS42_18165	COG0728	peptidoglycan biosynthetic process
CVS42_18170	COG0268	Binds directly to 16S ribosomal RNA
CVS42_18175	COG0640	Transcriptional regulator
CVS42_18180	COG0583	DNA-binding transcription factor activity
CVS42_18190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_18195	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CVS42_18200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CVS42_18205	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CVS42_18210	COG1051	belongs to the nudix hydrolase family
CVS42_18215	COG3066	DNA modification
CVS42_18225	COG0335	large ribosomal subunit rRNA binding
CVS42_18230	COG0336	Belongs to the RNA methyltransferase TrmD family
CVS42_18235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CVS42_18240	COG0228	four-way junction DNA binding
CVS42_18245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CVS42_18250	COG4137	Cytochrome C assembly protein
CVS42_18255	COG4536	flavin adenine dinucleotide binding
CVS42_18265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CVS42_18265	COG1017	nitric oxide dioxygenase activity
CVS42_18270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CVS42_18275	COG0039	L-malate dehydrogenase activity
CVS42_18280	COG4160	amino acid transport
CVS42_18285	COG4215	(ABC) transporter
CVS42_18290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_18295	COG1126	abc transporter atp-binding protein
CVS42_18300	COG1438	arginine binding
CVS42_18305	COG2837	iron assimilation
CVS42_18310	COG3842	ATPase activity
CVS42_18320	COG1840	ABC-type Fe3 transport system, periplasmic component
CVS42_18325	COG0347	Belongs to the P(II) protein family
CVS42_18345	COG3022	response to hydroperoxide
CVS42_18360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CVS42_18365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CVS42_18370	COG0762	integral membrane protein
CVS42_18375	COG1872	DUF167
CVS42_18385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CVS42_18390	COG0583	DNA-binding transcription factor activity
CVS42_18405	COG1929	Belongs to the glycerate kinase type-1 family
CVS42_18410	COG2610	gluconate transmembrane transporter activity
CVS42_18415	COG3835	regulator
CVS42_18420	COG3112	Uncharacterised protein family (UPF0231)
CVS42_18440	COG3568	Endonuclease Exonuclease Phosphatase
CVS42_18450	COG0513	Belongs to the DEAD box helicase family
CVS42_18490	COG1448	Aminotransferase
CVS42_18505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CVS42_18510	COG1328	CTP reductase activity
CVS42_18525	COG0543	2 iron, 2 sulfur cluster binding
CVS42_18525	COG0633	Ferredoxin
CVS42_18540	COG1215	transferase activity, transferring glycosyl groups
CVS42_18545	COG1649	PFAM Uncharacterised BCR, COG1649
CVS42_18545	COG0726	polysaccharide deacetylase
CVS42_18560	COG4783	chaperone-mediated protein folding
CVS42_18565	COG1215	transferase activity, transferring glycosyl groups
CVS42_18570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CVS42_18580	COG0840	transmembrane signaling receptor activity
CVS42_18585	COG3397	chitin binding
CVS42_18590	COG0583	DNA-binding transcription factor activity
CVS42_18595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CVS42_18600	COG4208	sulfate ABC transporter
CVS42_18605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CVS42_18615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CVS42_18620	COG3174	membrane
CVS42_18625	COG0110	maltose O-acetyltransferase activity
CVS42_18640	COG1011	Hydrolase
CVS42_18645	COG0494	nUDIX hydrolase
CVS42_18650	COG1218	3'(2'),5'-bisphosphate nucleotidase
CVS42_18655	COG0814	amino acid
CVS42_18660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_18675	COG0626	cystathionine gamma-synthase activity
CVS42_18680	COG0460	homoserine dehydrogenase
CVS42_18680	COG0527	aspartate kinase activity
CVS42_18690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CVS42_18695	COG0508	dehydrogenase complex catalyzes the overall conversion of
CVS42_18700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CVS42_18705	COG2186	Transcriptional regulator
CVS42_18735	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_18740	COG1459	type II secretion system
CVS42_18755	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CVS42_18760	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CVS42_18765	COG0494	nUDIX hydrolase
CVS42_18770	COG0653	protein targeting
CVS42_18780	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CVS42_18785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CVS42_18790	COG0849	cell division
CVS42_18800	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CVS42_18805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CVS42_18810	COG0772	Belongs to the SEDS family
CVS42_18815	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CVS42_18820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CVS42_18825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CVS42_18835	COG0768	penicillin binding
CVS42_18840	COG3116	cell division
CVS42_18845	COG0275	rRNA processing
CVS42_18850	COG2001	Belongs to the MraZ family
CVS42_18860	COG1388	LysM domain
CVS42_18860	COG0741	lytic transglycosylase activity
CVS42_18875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CVS42_18880	COG1191	sigma factor activity
CVS42_18905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CVS42_18910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_18925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CVS42_18930	COG4786	Flagellar basal body rod
CVS42_18930	COG1256	bacterial-type flagellum assembly
CVS42_18940	COG1706	bacterial-type flagellum-dependent cell motility
CVS42_18945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CVS42_18950	COG4786	Flagellar basal body rod
CVS42_18955	COG4787	bacterial-type flagellum-dependent cell motility
CVS42_18960	COG1749	Flagellar hook protein flgE
CVS42_18965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CVS42_18970	COG1558	bacterial-type flagellum-dependent cell motility
CVS42_18975	COG1815	bacterial-type flagellum-dependent cell motility
CVS42_19010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CVS42_19020	COG1677	Flagellar hook-basal body complex protein FliE
CVS42_19025	COG2204	response regulator
CVS42_19045	COG1987	bacterial-type flagellum assembly
CVS42_19070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CVS42_19075	COG3107	peptidoglycan biosynthetic process
CVS42_19080	COG0792	nuclease activity
CVS42_19085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CVS42_19090	COG2823	Periplasmic or secreted lipoprotein
CVS42_19095	COG2969	positive regulation of protein catabolic process
CVS42_19100	COG0625	glutathione transferase activity
CVS42_19105	COG2857	Cytochrome c1
CVS42_19110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CVS42_19115	COG0723	plastoquinol--plastocyanin reductase activity
CVS42_19120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CVS42_19125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CVS42_19130	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CVS42_19140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS42_19145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CVS42_19175	COG3964	amidohydrolase
CVS42_19190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_19190	COG3711	transcriptional antiterminator
CVS42_19195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_19200	COG1660	Displays ATPase and GTPase activities
CVS42_19205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_19220	COG1137	ATPase activity
CVS42_19225	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CVS42_19230	COG3117	lipopolysaccharide transmembrane transporter activity
CVS42_19235	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CVS42_19240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CVS42_19240	COG0517	IMP dehydrogenase activity
CVS42_19245	COG1127	ABC transporter
CVS42_19250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CVS42_19255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CVS42_19260	COG2854	intermembrane phospholipid transfer
CVS42_19270	COG5007	Belongs to the BolA IbaG family
CVS42_19275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CVS42_19280	COG0312	modulator of DNA gyrase
CVS42_19285	COG3028	Belongs to the UPF0307 family
CVS42_19290	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CVS42_19310	COG1011	Hydrolase
CVS42_19325	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CVS42_19330	COG0019	diaminopimelate decarboxylase activity
CVS42_19340	COG1965	Belongs to the frataxin family
CVS42_19345	COG0400	carboxylic ester hydrolase activity
CVS42_19350	COG3072	Adenylate cyclase
CVS42_19355	COG0181	hydroxymethylbilane synthase activity
CVS42_19365	COG2959	enzyme of heme biosynthesis
CVS42_19380	COG1494	fructose-1,6-bisphosphatase
CVS42_19400	COG0531	amino acid
CVS42_19430	COG3501	Rhs element vgr protein
CVS42_19440	COG3209	COG3209 Rhs family protein
CVS42_19440	COG4104	PAAR repeat-containing protein
CVS42_19450	COG3209	COG3209 Rhs family protein
CVS42_19450	COG4104	PAAR repeat-containing protein
CVS42_19480	COG4584	PFAM Integrase catalytic
CVS42_19485	COG1484	DNA-dependent DNA replication
CVS42_19500	COG0850	regulation of cytokinetic process
CVS42_19505	COG3100	YcgL domain-containing protein
CVS42_19515	COG0306	phosphate transporter
CVS42_19520	COG1392	Phosphate transport regulator
CVS42_19530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CVS42_19535	COG2813	Specifically methylates the guanine in position
CVS42_19540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CVS42_19545	COG0297	glycogen (starch) synthase activity
CVS42_19585	COG1757	Na H antiporter
CVS42_19590	COG0316	Belongs to the HesB IscA family
CVS42_19600	COG0038	chloride channel
CVS42_19605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CVS42_19625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS42_19625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CVS42_19640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CVS42_19645	COG0564	pseudouridine synthase activity
CVS42_19660	COG0110	maltose O-acetyltransferase activity
CVS42_19665	COG0366	Alpha amylase catalytic
CVS42_19670	COG1263	PTS System
CVS42_19670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CVS42_19690	COG0252	asparaginase activity
CVS42_19695	COG1253	flavin adenine dinucleotide binding
CVS42_19700	COG0586	Pfam SNARE associated Golgi protein
CVS42_19705	COG1686	Belongs to the peptidase S11 family
CVS42_19740	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CVS42_19745	COG0527	aspartate kinase activity
CVS42_19750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CVS42_19760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CVS42_19765	COG1546	Belongs to the CinA family
CVS42_19770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CVS42_19775	COG4667	esterase of the alpha-beta hydrolase superfamily
CVS42_19785	COG1346	cytolysis
CVS42_19790	COG1380	Effector of murein hydrolase LrgA
CVS42_19795	COG0583	DNA-binding transcription factor activity
CVS42_19805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CVS42_19850	COG1396	sequence-specific DNA binding
CVS42_19855	COG3135	benzoate transporter
CVS42_19880	COG0840	transmembrane signaling receptor activity
CVS42_19885	COG3047	cAMP biosynthetic process
CVS42_19890	COG3706	GGDEF domain
CVS42_19895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CVS42_19915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CVS42_19925	COG1278	Cold shock
CVS42_19930	COG2252	PERMEase
CVS42_19935	COG2376	Dihydroxyacetone kinase
CVS42_19940	COG1461	Dihydroxyacetone kinase
CVS42_19945	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CVS42_19945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CVS42_19945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CVS42_19955	COG3284	Transcriptional regulator
CVS42_19970	COG0628	permease
CVS42_19990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CVS42_20015	COG0456	acetyltransferase
CVS42_20020	COG3133	Outer membrane lipoprotein
CVS42_20025	COG0004	ammonium transporteR
CVS42_20030	COG3706	GGDEF domain
CVS42_20040	COG3932	Exopolysaccharide synthesis, ExoD
CVS42_20045	COG0814	amino acid
CVS42_20050	COG3706	GGDEF domain
CVS42_20060	COG0110	maltose O-acetyltransferase activity
CVS42_20080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CVS42_20085	COG2022	thiamine diphosphate biosynthetic process
CVS42_20095	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CVS42_20100	COG0352	thiamine-phosphate diphosphorylase activity
CVS42_20105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CVS42_20110	COG0754	glutathionylspermidine amidase activity
CVS42_20120	COG3766	membrane
CVS42_20140	COG0745	RESPONSE REGULATOR receiver
CVS42_20150	COG0189	ligase activity
CVS42_20195	COG0477	Major facilitator Superfamily
CVS42_20210	COG0312	modulator of DNA gyrase
CVS42_20215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CVS42_20230	COG3164	Protein of unknown function
CVS42_20235	COG1530	ribonuclease E activity
CVS42_20240	COG0424	maF-like protein
CVS42_20245	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CVS42_20250	COG1792	Involved in formation and maintenance of cell shape
CVS42_20255	COG1077	Cell shape determining protein MreB Mrl
CVS42_20280	COG4968	Prepilin-type N-terminal cleavage methylation domain
CVS42_20300	COG1459	type II secretion system
CVS42_20305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CVS42_20350	COG2199	diguanylate cyclase activity
CVS42_20350	COG2200	EAL domain
CVS42_20355	COG2200	EAL domain
CVS42_20360	COG0387	Pfam Sodium calcium exchanger
CVS42_20365	COG2986	histidine ammonia-lyase
CVS42_20370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CVS42_20375	COG0010	Belongs to the arginase family
CVS42_20380	COG1228	amidohydrolase
CVS42_20385	COG2188	Transcriptional regulator
CVS42_20390	COG0288	reversible hydration of carbon dioxide
CVS42_20400	COG2177	Part of the ABC transporter FtsEX involved in
CVS42_20405	COG2884	Cell division ATP-binding protein ftsE
CVS42_20410	COG0552	protein localization to endoplasmic reticulum
CVS42_20415	COG0742	ribosomal rna small subunit methyltransferase
CVS42_20440	COG2249	NAD(P)H dehydrogenase (quinone) activity
CVS42_20445	COG0583	DNA-binding transcription factor activity
CVS42_20450	COG4221	oxidoreductase activity
CVS42_20465	COG1770	oligopeptidase
CVS42_20480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CVS42_20485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CVS42_20495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_20505	COG2095	MarC family integral membrane protein
CVS42_20515	COG1301	dicarboxylic acid transport
CVS42_20540	COG3714	YhhN family
CVS42_20590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CVS42_20595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS42_20600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CVS42_20605	COG0049	tRNA binding
CVS42_20610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CVS42_20615	COG2168	tRNA wobble position uridine thiolation
CVS42_20620	COG2923	Belongs to the DsrF TusC family
CVS42_20625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CVS42_20635	COG2964	Protein conserved in bacteria
CVS42_20640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CVS42_20645	COG0085	RNA polymerase activity
CVS42_20650	COG0222	ribosome binding
CVS42_20655	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CVS42_20660	COG0081	regulation of translation
CVS42_20665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CVS42_20670	COG0250	Participates in transcription elongation, termination and antitermination
CVS42_20675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CVS42_20685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CVS42_20710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CVS42_20715	COG0569	domain protein
CVS42_20720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_20750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CVS42_20750	COG4191	Histidine kinase
CVS42_20755	COG3005	denitrification pathway
CVS42_20760	COG0243	molybdopterin cofactor binding
CVS42_20770	COG2205	protein histidine kinase activity
CVS42_20775	COG0745	RESPONSE REGULATOR receiver
CVS42_20810	COG2204	response regulator
CVS42_20820	COG2205	protein histidine kinase activity
CVS42_20835	COG1028	Short-chain dehydrogenase reductase Sdr
CVS42_20840	COG0516	GMP reductase activity
CVS42_20840	COG0517	IMP dehydrogenase activity
CVS42_20845	COG5413	integral membrane protein
CVS42_20855	COG1522	sequence-specific DNA binding
CVS42_20860	COG2502	aspartate--ammonia ligase
CVS42_20865	COG0542	response to heat
CVS42_20875	COG0564	pseudouridine synthase activity
CVS42_20880	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CVS42_20885	COG0446	pyridine nucleotide-disulphide oxidoreductase
CVS42_20895	COG3681	Belongs to the UPF0597 family
CVS42_20900	COG2964	Protein conserved in bacteria
CVS42_20910	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CVS42_20915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CVS42_20920	COG1979	alcohol dehydrogenase
CVS42_20925	COG2207	Transcriptional regulator
CVS42_20945	COG0583	DNA-binding transcription factor activity
CVS42_20960	COG0540	Belongs to the ATCase OTCase family
CVS42_20965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CVS42_20970	COG1438	arginine binding
CVS42_20975	COG1288	antiporter activity
CVS42_20980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CVS42_21005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CVS42_21015	COG3078	GTPase activator activity
CVS42_21030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CVS42_21040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CVS42_21045	COG0408	coproporphyrinogen oxidase activity
CVS42_21050	COG0009	L-threonylcarbamoyladenylate synthase
CVS42_21060	COG0551	DNA topoisomerase type I activity
CVS42_21065	COG2922	Belongs to the Smg family
CVS42_21070	COG0758	DNA mediated transformation
CVS42_21075	COG1652	LysM domain
CVS42_21080	COG0242	peptide deformylase activity
CVS42_21085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CVS42_21090	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CVS42_21090	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CVS42_21095	COG0569	domain protein
CVS42_21100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_21110	COG0174	glutamine synthetase
CVS42_21120	COG3852	Histidine kinase
CVS42_21125	COG2204	response regulator
CVS42_21130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CVS42_21135	COG1322	Protein conserved in bacteria
CVS42_21155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CVS42_21160	COG0583	DNA-binding transcription factor activity
CVS42_21165	COG0519	Catalyzes the synthesis of GMP from XMP
CVS42_21165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CVS42_21180	COG1396	sequence-specific DNA binding
CVS42_21185	COG1012	belongs to the aldehyde dehydrogenase family
CVS42_21195	COG2962	Rard protein
CVS42_21205	COG2391	methyltransferase activity
CVS42_21215	COG1309	transcriptional regulator
CVS42_21240	COG1401	restriction endodeoxyribonuclease activity
CVS42_21250	COG0129	dihydroxy-acid dehydratase activity
CVS42_21255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CVS42_21260	COG3978	acetolactate synthase activity
CVS42_21270	COG0606	chelatase, subunit chli
CVS42_21275	COG0204	Acyl-transferase
CVS42_21280	COG0204	Acyl-transferase
CVS42_21285	COG1683	Conserved Protein
CVS42_21295	COG1335	isochorismatase
CVS42_21305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CVS42_21310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CVS42_21320	COG3084	Protein conserved in bacteria
CVS42_21325	COG2203	Gaf domain
CVS42_21325	COG3706	GGDEF domain
CVS42_21325	COG5001	Diguanylate cyclase
CVS42_21325	COG4251	negative regulation of phosphorylation
CVS42_21340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CVS42_21345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CVS42_21350	COG1561	YicC-like family, N-terminal region
CVS42_21355	COG0583	DNA-binding transcription factor activity
CVS42_21375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CVS42_21380	COG0385	Bile acid
CVS42_21385	COG0531	amino acid
CVS42_21390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CVS42_21395	COG0531	amino acid
CVS42_21400	COG2731	YhcH YjgK YiaL family protein
CVS42_21405	COG3250	beta-galactosidase activity
CVS42_21410	COG1609	Transcriptional regulator
CVS42_21450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CVS42_21455	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_21455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CVS42_21465	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CVS42_21470	COG3074	FtsZ-dependent cytokinesis
CVS42_21480	COG1045	serine acetyltransferase
CVS42_21490	COG0745	RESPONSE REGULATOR receiver
CVS42_21495	COG2205	protein histidine kinase activity
CVS42_21500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CVS42_21505	COG0534	Mate efflux family protein
CVS42_21520	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CVS42_21525	COG2937	Belongs to the GPAT DAPAT family
CVS42_21530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CVS42_21535	COG3161	chorismate lyase activity
CVS42_21560	COG0604	alcohol dehydrogenase
CVS42_21565	COG1519	Transferase
CVS42_21570	COG0859	PFAM glycosyl transferase family 9
CVS42_21575	COG0463	Glycosyl transferase, family 2
CVS42_21580	COG0859	PFAM glycosyl transferase family 9
CVS42_21585	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CVS42_21590	COG2990	Protein conserved in bacteria
CVS42_21595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CVS42_21605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CVS42_21610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CVS42_21615	COG2003	Belongs to the UPF0758 family
CVS42_21620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CVS42_21625	COG0756	dUTP diphosphatase activity
CVS42_21630	COG1309	transcriptional regulator
CVS42_21635	COG0668	transmembrane transport
CVS42_21640	COG0166	Belongs to the GPI family
CVS42_21645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CVS42_21650	COG0583	DNA-binding transcription factor activity
CVS42_21665	COG1042	CoA-binding domain protein
CVS42_21665	COG0045	succinate-CoA ligase (ADP-forming) activity
CVS42_21665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CVS42_21700	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CVS42_21705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CVS42_21710	COG1739	Uncharacterized protein family UPF0029
CVS42_21715	COG0006	proline dipeptidase activity
CVS42_21720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CVS42_21725	COG1024	Enoyl-CoA hydratase
CVS42_21725	COG1250	3-hydroxyacyl-CoA dehydrogenase
CVS42_21730	COG0183	Belongs to the thiolase family
CVS42_21735	COG0745	RESPONSE REGULATOR receiver
CVS42_21740	COG2205	protein histidine kinase activity
CVS42_21755	COG0425	Belongs to the sulfur carrier protein TusA family
CVS42_21760	COG0251	oxidation-reduction process
CVS42_21765	COG2885	chlorophyll binding
CVS42_21770	COG2818	Glycosylase
CVS42_21775	COG0752	glycyl-tRNA synthetase alpha subunit
CVS42_21780	COG0751	glycine-tRNA ligase activity
CVS42_21790	COG2200	EAL domain
CVS42_21790	COG2202	Pas domain
CVS42_21790	COG2199	diguanylate cyclase activity
CVS42_21835	COG1609	Transcriptional regulator
CVS42_21845	COG0559	Belongs to the binding-protein-dependent transport system permease family
CVS42_21865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CVS42_21880	COG2960	long-chain fatty acid transporting porin activity
CVS42_21885	COG5001	Diguanylate cyclase
CVS42_21895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CVS42_21905	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CVS42_21910	COG3118	belongs to the thioredoxin family
CVS42_21915	COG0513	Belongs to the DEAD box helicase family
CVS42_21920	COG0248	Ppx GppA phosphatase
CVS42_21930	COG0742	ribosomal rna small subunit methyltransferase
CVS42_21950	COG3469	chitinase activity
CVS42_21955	COG3397	chitin binding
CVS42_21965	COG0084	hydrolase, TatD family'
CVS42_21970	COG0805	protein transport
CVS42_21975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_21980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CVS42_21985	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CVS42_21990	COG3165	ubiquinone biosynthetic process from chorismate
CVS42_21995	COG2226	methyltransferase
CVS42_22000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CVS42_22005	COG0402	S-adenosylhomocysteine deaminase activity
CVS42_22010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CVS42_22045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CVS42_22050	COG0848	biopolymer transport protein
CVS42_22055	COG0811	peptide transport
CVS42_22060	COG0811	peptide transport
CVS42_22070	COG2771	luxR family
CVS42_22075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CVS42_22080	COG1349	DNA-binding transcription factor activity
CVS42_22085	COG0745	RESPONSE REGULATOR receiver
CVS42_22090	COG2205	protein histidine kinase activity
CVS42_22105	COG4452	Inner membrane protein CreD
CVS42_22110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CVS42_22115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CVS42_22120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CVS42_22125	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CVS42_22130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CVS42_22135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CVS42_22140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CVS42_22150	COG0356	it plays a direct role in the translocation of protons across the membrane
CVS42_22160	COG1475	DNA binding
CVS42_22165	COG1192	Involved in chromosome partitioning
CVS42_22170	COG0357	Ribosomal RNA small subunit methyltransferase G
CVS42_22175	COG0445	tRNA wobble uridine modification
CVS42_22180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CVS42_22190	COG4615	Cyclic peptide transporter
CVS42_22195	COG1120	ATPase activity
CVS42_22200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CVS42_22205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily