locus-tag	class	description
APE_0009.1	ENOG410681U	heavy metal transport detoxification protein
APE_0010.1	ENOG4107RY6	amino acid
APE_0011.1	ENOG41061GT	Aldolase
APE_0012	ENOG4105D7K	pfkb domain protein
APE_0013.1	ENOG4105C01	Dihydroxy-acid dehydratase
APE_0017.1	ENOG4105CMG	Carbohydrate kinase
APE_0026	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
APE_0033.1	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
APE_0035.1	ENOG4107YY3	extracellular solute-binding protein family 1
APE_0038.1	ENOG4105S9S	Binding-protein-dependent transport systems, inner membrane component
APE_0040.1	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
APE_0043.1	ENOG4108IJ9	(ABC) transporter
APE_0048	ENOG4105E2Z	phosphate ABC transporter (Permease
APE_0050	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
APE_0056.1	ENOG4105E39	Enoyl-CoA hydratase
APE_0060.1	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
APE_0063	ENOG4105C2J	ABC transporter
APE_0072	ENOG4105CRE	cytochrome C
APE_0077	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APE_0079	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
APE_0084.1	ENOG4108DBC	nitroreductase
APE_0086	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APE_0089.1	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
APE_0099	ENOG4105CQ2	DNA polymerase
APE_0101.1	ENOG4105DF6	Fe-S oxidoreductase
APE_0105	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
APE_0110	ENOG4107WZZ	SMC domain protein
APE_0110	ENOG4107WZZ	SMC domain protein
APE_0117.1	ENOG4105C22	threonyL-tRNA synthetase
APE_0119	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
APE_0127	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
APE_0134.1	ENOG4105CV7	Electron transfer flavoprotein
APE_0135	ENOG4105C10	Electron transfer flavoprotein
APE_0137	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
APE_0159	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
APE_0163.1	ENOG4105C26	Dehydrogenase
APE_0169.1	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
APE_0173.1	ENOG4105BZA	Phosphoglycerate kinase
APE_0179	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
APE_0181	ENOG4105CY0	Metallo-Beta-Lactamase
APE_0182.1	ENOG4105VZ9	UPF0235 protein
APE_0191.1	ENOG4105CQR	helicase
APE_0193.1	ENOG4108535	NAD dependent epimerase/dehydratase family
APE_0204.1	ENOG4108UMS	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)
APE_0216.1	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
APE_0218	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APE_0222.1	ENOG4105CR4	methylisocitrate lyase
APE_0228a.1	ENOG41082UH	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
APE_0230.1	ENOG4105D1F	ATP-binding protein
APE_0236.1	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
APE_0244.1	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
APE_0246.1	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
APE_0248.1	ENOG4105E63	Pfam:DUF178
APE_0249.1	ENOG4105DVY	radical SAM domain protein
APE_0252	ENOG4105DVY	radical SAM domain protein
APE_0255.1	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
APE_0260.1	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
APE_0262	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
APE_0263.1	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
APE_0267	ENOG41080XP	Cbs domain
APE_0272.1	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
APE_0288	ENOG41062A4	Transcriptional regulator
APE_0291	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APE_0300.1	ENOG4108JQ7	(ABC) transporter
APE_0301.1	ENOG4105C3U	ABC transporter
APE_0302.1	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APE_0303	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APE_0304.1	ENOG4105DEF	Extracellular solute-binding protein, family 5
APE_0306.1	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
APE_0308.1	ENOG4105CQB	FAD linked oxidase domain protein
APE_0316.1	ENOG4105CYW	agmatinase
APE_0317.1	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
APE_0319	ENOG4108Z0Z	intracellular protease Pfpi family
APE_0320.1	ENOG410688J	Ferredoxin
APE_0326.1	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APE_0333.1	ENOG4105DHP	deoxycytidine triphosphate deaminase
APE_0336.1	ENOG4105CUJ	penicillin amidase
APE_0338.1	ENOG4105FQP	Beta-lactamase
APE_0342.1	ENOG4108S4H	thioesterase Superfamily protein
APE_0346	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
APE_0350	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
APE_0352.1	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
APE_0354.1	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APE_0356.1	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
APE_0358	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
APE_0359	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
APE_0362a	ENOG41082SA	50s ribosomal protein l29
APE_0365	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
APE_0367.1	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
APE_0374	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
APE_0382	ENOG4105C5X	domain protein
APE_0383.1	ENOG4105C2X	Arabinose 5-phosphate isomerase
APE_0385.1	ENOG4105CSU	acyl-Coa dehydrogenase
APE_0396.1	ENOG4105CEY	Amp-dependent synthetase and ligase
APE_0401.1	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
APE_0404.1	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
APE_0405.1	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
APE_0412	ENOG4105DY8	decarboxylase
APE_0413	ENOG4105C0D	helicase
APE_0423.1	ENOG4108RE7	deoxyribonuclease
APE_0427.1	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
APE_0436.1	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APE_0445	ENOG41060GV	RNA binding s1 domain protein
APE_0449	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
APE_0454	ENOG4105PW4	Sugar fermentation stimulation protein homolog
APE_0457	ENOG4108JPW	Aminotransferase
APE_0471.1	ENOG4105CIG	ABC transporter
APE_0475.1	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
APE_0478.1	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APE_0487	ENOG4105CQB	FAD linked oxidase domain protein
APE_0496.1	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
APE_0510.1	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APE_0511.1	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
APE_0514	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APE_0517	ENOG4108YZY	peptidylprolyl cis-trans isomerase
APE_0519.1	ENOG4108MDK	Dehydrogenase
APE_0521.1	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
APE_0522.1	ENOG4105CY0	Metallo-Beta-Lactamase
APE_0525.1	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
APE_0526.1	ENOG4105DC7	peptidase M24
APE_0545.1	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
APE_0553	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
APE_0555.1	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
APE_0557	ENOG4108T9W	RNA methylase
APE_0564	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
APE_0569	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
APE_0574.1	ENOG4105E2X	shikimate dehydrogenase
APE_0579	ENOG4105D49	3-dehydroquinate synthase
APE_0581.1	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
APE_0586.1	ENOG4108HHA	Transketolase
APE_0591.1	ENOG4108UKI	Enoyl-CoA hydratase
APE_0595.1	ENOG4105CEP	NADH dehydrogenase
APE_0607	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
APE_0621.1	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
APE_0624.1	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
APE_0632.1	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
APE_0639.1	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
APE_0641	ENOG4105K63	Thioredoxin
APE_0650.1	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
APE_0662.1	ENOG4105CUT	histidyl-tRNA synthetase
APE_0665	ENOG4105E66	phosphoriboisomerase A
APE_0669.1	ENOG4105ETU	transcriptional activator (TenA
APE_0672.1	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
APE_0674.1	ENOG4105CHM	Aminotransferase
APE_0675.1	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
APE_0676	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
APE_0677.1	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
APE_0686	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
APE_0689.1	ENOG4108HMX	isocitrate dehydrogenase (NADP)
APE_0695.1	ENOG4108EHY	type IV secretion system
APE_0712.1	ENOG4105DTQ	mandelate racemase muconate lactonizing
APE_0715.1	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
APE_0739	ENOG4105C1G	acyl-Coa dehydrogenase
APE_0741	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
APE_0745.1	ENOG4105EHU	Circadian clock protein KaiC
APE_0767.1	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
APE_0782.1	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
APE_0785.1	ENOG4105CJW	magnesium transporter
APE_0792.1	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
APE_0793.1	ENOG4105BZ9	Cytochrome C oxidase, subunit I
APE_0801.1	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
APE_0805	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
APE_0807.1	ENOG4105C26	Dehydrogenase
APE_0815.1	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
APE_0872.1	ENOG4105NI8	Cytosine-specific methyltransferase
APE_0892.1	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APE_0903.1	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
APE_0907.1	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
APE_0912	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
APE_0919	ENOG4105C0Z	ABC transporter
APE_0921	ENOG4108IV0	ABC, transporter
APE_0929.1	ENOG4105CHU	acetyl-coa acetyltransferase
APE_0935	ENOG4105BZ8	glutamate synthase
APE_0941	ENOG4105D38	putrescine abc transporter
APE_0943	ENOG4105F38	ABC transporter, permease
APE_0944.1	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APE_0945.1	ENOG4107XW0	Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein
APE_0946	ENOG4105E33	succinate dehydrogenase
APE_0951.1	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
APE_0955	ENOG4105EYW	Ion transport protein
APE_0959	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
APE_0960	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APE_0966.1	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
APE_0972.1	ENOG4105CK7	Sodium proline symporter
APE_0974.1	ENOG4105C2X	Arabinose 5-phosphate isomerase
APE_0978.1	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
APE_0986.1	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
APE_0993.1	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
APE_0996.1	ENOG4105D1Z	hydroxypyruvate reductase
APE_1011.1	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
APE_1015	ENOG4105C8T	Leucyl-tRNA synthetase
APE_1026.1	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
APE_1038.1	ENOG4105KG3	cytidine deaminase
APE_1043.1	ENOG4105CEP	NADH dehydrogenase
APE_1044	ENOG4108DBC	nitroreductase
APE_1045.1	ENOG4105D0M	Protease HtpX homolog
APE_1049.1	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
APE_1053.1	ENOG4105EHG	Permease protein
APE_1055.1	ENOG4105DIK	(ABC) transporter
APE_1056.1	ENOG4105NBF	ammecr1 domain protein
APE_1061.1	ENOG4105C3M	thioredoxin reductase
APE_1065.1	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
APE_1072.1	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
APE_1073	ENOG4105CFI	type iii restriction protein res subunit
APE_1081.1	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
APE_1094.1	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
APE_1098	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APE_1104.1	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
APE_1106.1	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
APE_1109.1	ENOG4107NFR	Fructose-1,6-bisphosphatase
APE_1117	ENOG4105E8R	UPF0173 metal-dependent hydrolase
APE_1119.1	ENOG4105DIK	(ABC) transporter
APE_1129	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
APE_1135	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APE_1138.1	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
APE_1139	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
APE_1140.1	ENOG4105CFH	Aspartokinase
APE_1143	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
APE_1144.1	ENOG4105D6E	homoserine dehydrogenase
APE_1156.1	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
APE_1158.1	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APE_1164	ENOG4105C3G	gtp-binding protein
APE_1180	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
APE_1181	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
APE_1183	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
APE_1191	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
APE_1195.1	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
APE_1197.1	ENOG4107RIQ	Sulfate adenylate transferase
APE_1205.1	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
APE_1208.1	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
APE_1209f	ENOG4105C1G	acyl-Coa dehydrogenase
APE_1226	ENOG4105C28	cystathionine
APE_1245.1	ENOG4105CPQ	Dehydrogenase
APE_1253	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
APE_1260	ENOG4105C5X	domain protein
APE_1275	ENOG4105C0F	tryptophanase EC 4.1.99.1
APE_1294.1	ENOG4108IUE	nitrate reductase beta subunit
APE_1300.1	ENOG4105R3A	Nitrate reductase
APE_1301.1	ENOG4108IV0	ABC, transporter
APE_1304.1	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
APE_1307	ENOG4108IQE	Amp-dependent synthetase and ligase
APE_1308	ENOG4105C0Z	ABC transporter
APE_1310	ENOG4105CEY	Amp-dependent synthetase and ligase
APE_1317	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
APE_1340.1	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
APE_1346.1	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APE_1350.1	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APE_1353.1	ENOG4105C9U	ATP-dependent DNA helicase RecQ
APE_1367	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APE_1376.1	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
APE_1380.1	ENOG4105CJ1	ABC, transporter
APE_1385	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
APE_1386.1	ENOG4105D82	Glutamate dehydrogenase
APE_1390.1	ENOG4105DEF	Extracellular solute-binding protein, family 5
APE_1395.1	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APE_1396	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APE_1402.1	ENOG4108JQ7	(ABC) transporter
APE_1404.1	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
APE_1410.1	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APE_1421.1	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
APE_1422	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APE_1426	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APE_1428.1	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
APE_1432	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
APE_1436.1	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
APE_1445	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APE_1447	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
APE_1454.1	ENOG4105C59	p-type ATPase
APE_1461.1	ENOG4107U4Q	acetylglutamate kinase
APE_1462	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
APE_1463	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
APE_1464	ENOG4105C8Y	Acetylornithine aminotransferase
APE_1467.1	ENOG4108KB0	deacetylase
APE_1470.1	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
APE_1471.1	ENOG4107Z8Z	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
APE_1472	ENOG4105DQU	oxidoreductase, subunit beta
APE_1473.1	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
APE_1481.1	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
APE_1484.1	ENOG4105E39	Enoyl-CoA hydratase
APE_1488.1	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
APE_1491.1	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
APE_1495a	ENOG4105MRR	Transcriptional regulator (By similarity)
APE_1498.1	ENOG4105C7B	Threonine dehydratase
APE_1501.1	ENOG4105KME	endoribonuclease L-psp
APE_1505.1	ENOG4105EHU	Circadian clock protein KaiC
APE_1516.1	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
APE_1520.1	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
APE_1522.1	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
APE_1524.1	ENOG4105D1H	recombination factor protein RarA
APE_1530.1	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APE_1538.1	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
APE_1543	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
APE_1547.1	ENOG4105C5Z	peptidase
APE_1555.1	ENOG4107R4J	Chloride channel
APE_1564.1	ENOG4108T9Q	UPF0278 protein
APE_1571.1	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
APE_1576	ENOG4108JQ7	(ABC) transporter
APE_1578	ENOG4105C3U	ABC transporter
APE_1581.1	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APE_1582	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APE_1586	ENOG4105C6T	cysteine synthase
APE_1586a	ENOG4105C1G	acyl-Coa dehydrogenase
APE_1588a	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
APE_1591.1	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
APE_1592.1	ENOG4105C8N	cysteinyl-tRNA synthetase
APE_1596	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
APE_1604	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
APE_1616.1	ENOG4105E3H	phosphoglycerate mutase
APE_1618.1	ENOG4107QM5	aconitate hydratase
APE_1622.1	ENOG41061H0	Monooxygenase
APE_1623	ENOG4107RQ2	Cytochrome c oxidase, subunit I
APE_1635.1	ENOG4108IJ9	(ABC) transporter
APE_1647	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
APE_1648.1	ENOG4108UVJ	appr-1-p processing domain protein
APE_1659	ENOG4105CPC	Aldo Keto reductase
APE_1662.1	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
APE_1663.1	ENOG4105CXT	aspartate transcarbamylase
APE_1668	ENOG4105VF7	tolerance protein
APE_1669.1	ENOG4107QN2	dihydrolipoyl dehydrogenase
APE_1674	ENOG4105CPP	Dehydrogenase, E1 component
APE_1681.1	ENOG4105C1G	acyl-Coa dehydrogenase
APE_1686.1	ENOG4105D5P	Methylmalonyl-coA mutase
APE_1694.1	ENOG4107VFP	cytochrome oxidase assembly
APE_1695.1	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
APE_1702	ENOG4105C3K	feS assembly ATPase SufC
APE_1713	ENOG4105BZN	citrate synthase
APE_1717.1	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
APE_1718	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
APE_1720	ENOG4105NAA	Cytochrome C oxidase, subunit II
APE_1722	ENOG4105K63	Thioredoxin
APE_1723.1	ENOG4107ZBN	O-methyltransferase
APE_1725	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
APE_1730.1	ENOG4105D38	putrescine abc transporter
APE_1732	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
APE_1735	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APE_1737.1	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APE_1739.1	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
APE_1742.1	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
APE_1747	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
APE_1749	ENOG4108UJD	30S ribosomal protein S9
APE_1750	ENOG4105CE9	30S ribosomal protein S2
APE_1765.1	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
APE_1771	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
APE_1773.1	ENOG4107QI1	Mate efflux family protein
APE_1775.1	ENOG4105CTD	carboxy-peptidase
APE_1782.1	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
APE_1786.1	ENOG4105C26	Dehydrogenase
APE_1792	ENOG4105M7V	2'-5' rna ligase
APE_1794	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
APE_1797	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
APE_1805.1	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
APE_1829	ENOG4105CJ1	ABC, transporter
APE_1831.1	ENOG4105C5I	Dehydrogenase
APE_1832	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
APE_1834.1	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
APE_1836.1	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
APE_1838.1	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
APE_1842	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
APE_1844	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
APE_1846.1	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
APE_1856	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
APE_1873.1	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
APE_1874.1	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
APE_1878	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
APE_1885	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
APE_1892	ENOG4105E5Q	amino acid AbC transporter
APE_1893.1	ENOG4105CHQ	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)
APE_1911.1	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
APE_1917	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
APE_1932.1	ENOG4108SDH	ABC, transporter
APE_1940.1	ENOG41080HJ	6-phospho 3-hexuloisomerase
APE_1958.1	ENOG4105C4K	Nad synthetase
APE_1961	ENOG4105CV8	reductase
APE_1962.1	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
APE_1968	ENOG4105C5B	carbamate kinase
APE_1976.1	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
APE_1979.1	ENOG4105VG1	fes assembly suf system protein
APE_1980.1	ENOG4105CEV	competence damage-inducible protein
APE_1992.1	ENOG4105DBV	ornithine carbamoyltransferase
APE_2007	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
APE_2012	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APE_2017	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
APE_2021.1	ENOG4105G5W	regulator Fur family
APE_2029.1	ENOG4108K7V	UPF0284 protein
APE_2035.1	ENOG4105CIH	Imidazole acetol-phosphate transaminase
APE_2037.1	ENOG4107ZET	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
APE_2039.1	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
APE_2044.1	ENOG4105C45	hydrogenase expression formation protein (HypE)
APE_2048	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
APE_2050.1	ENOG4107QYE	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
APE_2052.1	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APE_2060.1	ENOG4108IJ9	(ABC) transporter
APE_2062.1	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
APE_2064.1	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
APE_2066.1	ENOG4105E2K	Glycosyl transferase (Group 1
APE_2067.1	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
APE_2068	ENOG4105C28	cystathionine
APE_2072.1	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
APE_2074.1	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
APE_2078	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
APE_2081.1	ENOG4105C88	aminopeptidase
APE_2086	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
APE_2094.1	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
APE_2104.1	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
APE_2105.1	ENOG4108I5U	Uridine phosphorylase
APE_2106.1	ENOG4108RVA	ribokinase
APE_2109	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
APE_2121.1	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APE_2124.1	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APE_2125.1	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APE_2126.1	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
APE_2128	ENOG4105DQU	oxidoreductase, subunit beta
APE_2130.1	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
APE_2139a	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
APE_2142.1	ENOG4105C5F	glutamine synthetase
APE_2144.1	ENOG4107QRT	dEAD DEAH box helicase
APE_2149.1	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
APE_2153.1	ENOG4107QX8	SPFH domain, Band 7 family protein
APE_2154.1	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
APE_2154a	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
APE_2154b	ENOG4105C3U	ABC transporter
APE_2158.1	ENOG4105C1G	acyl-Coa dehydrogenase
APE_2162.1	ENOG4105D22	carbon starvation protein
APE_2165	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
APE_2166	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
APE_2173.1	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
APE_2174	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
APE_2188.1	ENOG4107QRT	dEAD DEAH box helicase
APE_2192.1	ENOG4105C5S	asparaginyl-tRNA synthetase
APE_2200	ENOG4105HDK	L-asparaginase
APE_2202	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
APE_2220.1	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
APE_2227	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
APE_2242.1	ENOG4105D1F	ATP-binding protein
APE_2247	ENOG4108VX5	3-methyladenine DNA glycosylase
APE_2248.1	ENOG4105CHM	Aminotransferase
APE_2252.1	ENOG4105EG2	ABC transporter, permease
APE_2257	ENOG4108J59	Extracellular solute-binding protein, family 5
APE_2258	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
APE_2260	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
APE_2263.1	ENOG4108JQ7	(ABC) transporter
APE_2272.1	ENOG4105D5T	phosphonate abc transporter
APE_2273.1	ENOG4105K63	Thioredoxin
APE_2278	ENOG4105D3R	alkyl hydroperoxide reductase
APE_2281.1	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
APE_2284.1	ENOG4105CEY	Amp-dependent synthetase and ligase
APE_2286	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
APE_2290.1	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
APE_2291	ENOG4105EJZ	Glucose-1-phosphate cytidylyltransferase
APE_2296	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
APE_2298.1	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
APE_2299.1	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
APE_2300.1	ENOG4105D52	delta-aminolevulinic acid dehydratase
APE_2302.1	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
APE_2305	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
APE_2308	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
APE_2316	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
APE_2317.1	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
APE_2328	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
APE_2341	ENOG4107UFM	Lipoate-protein ligase
APE_2342.1	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
APE_2344.1	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
APE_2348	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
APE_2349.1	ENOG4107SW0	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
APE_2350.1	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
APE_2354	ENOG4105C1G	acyl-Coa dehydrogenase
APE_2362.1	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
APE_2366.1	ENOG4105EM7	Selenocysteine-specific translation elongation factor
APE_2374	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
APE_2377	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
APE_2381.1	ENOG4105CRW	Short chain fatty acid transporter
APE_2392.1	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
APE_2397	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
APE_2400.1	ENOG4105DWF	phosphomethylpyrimidine kinase
APE_2406.1	ENOG4108JJB	ABC transporter
APE_2408.1	ENOG4108JJB	ABC transporter
APE_2418.1	ENOG4105BZJ	Electron transfer flavoprotein
APE_2419	ENOG4105C10	Electron transfer flavoprotein
APE_2421	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
APE_2423	ENOG4105C5R	Aminotransferase
APE_2433.1	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
APE_2437.1	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
APE_2439	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
APE_2441.1	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
APE_2446	ENOG4105CAG	UPF0210 protein
APE_2450.1	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
APE_2452	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
APE_2458	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
APE_2464.1	ENOG4108IAB	Phoh family
APE_2465.1	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
APE_2468.1	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
APE_2474.1	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
APE_2489.1	ENOG4105C2X	Arabinose 5-phosphate isomerase
APE_2495.1	ENOG4105K59	histidine triad (HIT) protein
APE_2497	ENOG41081FY	multiple antibiotic resistance (MarC)-related
APE_2503.1	ENOG4105CHR	reductase
APE_2507.1	ENOG4108JQ1	Dehydrogenase
APE_2522.1	ENOG4105C32	Amino acid ABC transporter (Permease)
APE_2524.1	ENOG4105C0Z	ABC transporter
APE_2526	ENOG4108IV0	ABC, transporter
APE_2533.1	ENOG4105C7Z	Conserved Protein
APE_2538	ENOG4107S6Z	Na H antiporter
APE_2540.1	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
APE_2548	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
APE_2550	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
APE_2553.1	ENOG4105CRQ	synthase (Component I)
APE_2555	ENOG4105DDQ	anthranilate synthase
APE_2556.1	ENOG4108K28	Arsenite oxidase, large subunit
APE_2575	ENOG4105CIH	Imidazole acetol-phosphate transaminase
APE_2580	ENOG4105CNW	domain protein
APE_2581	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
APE_2588	ENOG4105C2J	ABC transporter
APE_2595.1	ENOG4105KHC	sulfurtransferase
APE_2601.1	ENOG4105CEU	Arginine dihydrolase
APE_2604	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APE_2604a.1	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
APE_2605.1	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
APE_2610	ENOG4105DB1	molybdopterin oxidoreductase