locus-tag	class	description
ALSL_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALSL_0004	COG0187	DNA topoisomerase II activity
ALSL_0011	COG2091	lysine biosynthetic process via aminoadipic acid
ALSL_0012	COG0784	Response regulator, receiver
ALSL_0012	COG2198	Histidine kinase
ALSL_0012	COG2205	protein histidine kinase activity
ALSL_0016	COG0477	Major facilitator Superfamily
ALSL_0019	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALSL_0025	COG3186	Phenylalanine-4-hydroxylase
ALSL_0027	COG1522	sequence-specific DNA binding
ALSL_0031	COG3546	catalase activity
ALSL_0032	COG1881	PFAM PEBP family protein
ALSL_0038	COG1968	undecaprenyl-diphosphatase activity
ALSL_0040	COG0174	glutamine synthetase
ALSL_0044	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALSL_0044	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ALSL_0046	COG4771	TonB-dependent receptor
ALSL_0048	COG3852	Histidine kinase
ALSL_0049	COG2204	response regulator
ALSL_0052	COG0183	Belongs to the thiolase family
ALSL_0054	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_0060	COG1166	arginine decarboxylase activity
ALSL_0061	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_0063	COG4221	oxidoreductase activity
ALSL_0065	COG0018	arginyl-trna synthetase
ALSL_0067	COG2003	Belongs to the UPF0758 family
ALSL_0068	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ALSL_0069	COG0756	dUTP diphosphatase activity
ALSL_0073	COG0708	Exodeoxyribonuclease III
ALSL_0074	COG2223	nitrite transmembrane transporter activity
ALSL_0077	COG0739	heme binding
ALSL_0079	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALSL_0088	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ALSL_0089	COG1984	allophanate hydrolase subunit 2
ALSL_0090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ALSL_0091	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALSL_0091	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_0092	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALSL_0093	COG0752	glycyl-tRNA synthetase alpha subunit
ALSL_0096	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALSL_0097	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALSL_0098	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ALSL_0099	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALSL_0100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ALSL_0101	COG0210	DNA helicase
ALSL_0102	COG1435	thymidine kinase activity
ALSL_0105	COG3549	Plasmid maintenance system killer
ALSL_0106	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ALSL_0107	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ALSL_0111	COG1131	(ABC) transporter
ALSL_0113	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALSL_0113	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALSL_0114	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_0114	COG1506	peptidase
ALSL_0119	COG1201	RNA secondary structure unwinding
ALSL_0121	COG0697	spore germination
ALSL_0122	COG1187	pseudouridine synthase activity
ALSL_0124	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_0125	COG0667	Aldo Keto reductase
ALSL_0129	COG0531	amino acid
ALSL_0130	COG1063	alcohol dehydrogenase
ALSL_0131	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALSL_0132	COG0511	ligase activity, forming carbon-carbon bonds
ALSL_0133	COG0439	Biotin carboxylase
ALSL_0134	COG2264	protein methyltransferase activity
ALSL_0146	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_0148	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALSL_0150	COG0210	DNA helicase
ALSL_0151	COG0436	Aminotransferase
ALSL_0153	COG0668	transmembrane transport
ALSL_0157	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALSL_0158	COG1490	D-aminoacyl-tRNA deacylase activity
ALSL_0162	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALSL_0166	COG1215	transferase activity, transferring glycosyl groups
ALSL_0169	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALSL_0169	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALSL_0172	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALSL_0173	COG0242	peptide deformylase activity
ALSL_0175	COG0758	DNA mediated transformation
ALSL_0177	COG0009	L-threonylcarbamoyladenylate synthase
ALSL_0179	COG0151	Belongs to the GarS family
ALSL_0182	COG2816	NAD+ diphosphatase activity
ALSL_0183	COG0316	Belongs to the HesB IscA family
ALSL_0186	COG1051	belongs to the nudix hydrolase family
ALSL_0188	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALSL_0189	COG0166	Belongs to the GPI family
ALSL_0190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ALSL_0191	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ALSL_0192	COG0720	synthase
ALSL_0194	COG1538	Outer membrane efflux protein
ALSL_0195	COG1566	PFAM secretion protein HlyD family protein
ALSL_0196	COG2814	Major facilitator Superfamily
ALSL_0197	COG0662	Cupin 2, conserved barrel domain protein
ALSL_0197	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ALSL_0202	COG0626	cystathionine gamma-synthase activity
ALSL_0211	COG2086	electron transfer activity
ALSL_0215	COG0154	amidase activity
ALSL_0219	COG1127	ABC transporter
ALSL_0220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALSL_0221	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ALSL_0222	COG0509	glycine decarboxylation via glycine cleavage system
ALSL_0223	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ALSL_0228	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ALSL_0229	COG0463	Glycosyl transferase, family 2
ALSL_0230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALSL_0231	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ALSL_0235	COG1309	transcriptional regulator
ALSL_0237	COG1960	acyl-CoA dehydrogenase activity
ALSL_0238	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ALSL_0239	COG1518	maintenance of DNA repeat elements
ALSL_0239	COG1468	defense response to virus
ALSL_0246	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ALSL_0248	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALSL_0249	COG0626	cystathionine gamma-synthase activity
ALSL_0250	COG0460	homoserine dehydrogenase
ALSL_0250	COG0527	aspartate kinase activity
ALSL_0251	COG0531	amino acid
ALSL_0256	COG1760	l-serine dehydratase
ALSL_0259	COG3038	cytochrome b561
ALSL_0262	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALSL_0264	COG0795	lipopolysaccharide-transporting ATPase activity
ALSL_0269	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALSL_0271	COG0583	DNA-binding transcription factor activity
ALSL_0273	COG0308	aminopeptidase N
ALSL_0275	COG1214	PFAM Peptidase M22, glycoprotease
ALSL_0276	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALSL_0277	COG2059	Chromate
ALSL_0279	COG2259	Doxx family
ALSL_0281	COG1199	ATP-dependent helicase activity
ALSL_0285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALSL_0288	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALSL_0290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ALSL_0291	COG0792	nuclease activity
ALSL_0292	COG3107	peptidoglycan biosynthetic process
ALSL_0293	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALSL_0299	COG4772	TonB-dependent receptor
ALSL_0300	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_0301	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ALSL_0303	COG5006	permease, DMT superfamily
ALSL_0304	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_0305	COG0697	spore germination
ALSL_0307	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALSL_0308	COG0308	aminopeptidase N
ALSL_0314	COG3240	lipase activity
ALSL_0314	COG4625	pathogenesis
ALSL_0318	COG1040	competence protein
ALSL_0319	COG0840	transmembrane signaling receptor activity
ALSL_0325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALSL_0326	COG0440	acetolactate synthase activity
ALSL_0327	COG0028	Belongs to the TPP enzyme family
ALSL_0329	COG0129	dihydroxy-acid dehydratase activity
ALSL_0330	COG0473	3-isopropylmalate dehydrogenase activity
ALSL_0332	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ALSL_0337	COG0460	homoserine dehydrogenase
ALSL_0337	COG0527	aspartate kinase activity
ALSL_0340	COG0737	Belongs to the 5'-nucleotidase family
ALSL_0344	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ALSL_0345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALSL_0348	COG3012	SEC-C Motif Domain Protein
ALSL_0356	COG3245	cytochrome
ALSL_0361	COG0837	glucose binding
ALSL_0362	COG2723	6-phospho-beta-galactosidase activity
ALSL_0363	COG3842	ATPase activity
ALSL_0364	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_0369	COG3100	YcgL domain-containing protein
ALSL_0370	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_0374	COG4772	TonB-dependent receptor
ALSL_0375	COG0584	glycerophosphoryl diester phosphodiesterase
ALSL_0380	COG1565	acr, cog1565
ALSL_0380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ALSL_0388	COG0109	protoheme IX farnesyltransferase activity
ALSL_0389	COG0745	RESPONSE REGULATOR receiver
ALSL_0390	COG0642	Histidine kinase
ALSL_0400	COG0586	Pfam SNARE associated Golgi protein
ALSL_0401	COG0358	DNA primase activity
ALSL_0405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALSL_0406	COG3706	GGDEF domain
ALSL_0407	COG0302	gtp cyclohydrolase
ALSL_0408	COG1322	Protein conserved in bacteria
ALSL_0410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALSL_0412	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ALSL_0414	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ALSL_0414	COG0543	2 iron, 2 sulfur cluster binding
ALSL_0418	COG0456	acetyltransferase
ALSL_0422	COG1162	GTPase activity
ALSL_0423	COG2226	methyltransferase
ALSL_0424	COG0281	malic enzyme
ALSL_0424	COG0280	phosphate acetyltransferase
ALSL_0426	COG0469	pyruvate kinase activity
ALSL_0430	COG0438	transferase activity, transferring glycosyl groups
ALSL_0440	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_0440	COG1506	peptidase
ALSL_0444	COG2801	Transposase and inactivated derivatives
ALSL_0445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALSL_0448	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALSL_0449	COG0077	Prephenate dehydratase
ALSL_0449	COG1605	Chorismate mutase
ALSL_0453	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ALSL_0455	COG0322	excinuclease ABC activity
ALSL_0458	COG0582	viral genome integration into host DNA
ALSL_0464	COG2801	Transposase and inactivated derivatives
ALSL_0465	COG2963	transposase activity
ALSL_0469	COG2217	Heavy metal translocating P-type atpase
ALSL_0474	COG2132	Multicopper oxidase
ALSL_0475	COG0745	RESPONSE REGULATOR receiver
ALSL_0476	COG5002	protein histidine kinase activity
ALSL_0477	COG0640	Transcriptional regulator
ALSL_0480	COG0798	PFAM Bile acid sodium symporter
ALSL_0482	COG1695	Transcriptional regulator
ALSL_0499	COG2003	Belongs to the UPF0758 family
ALSL_0501	COG3039	Transposase
ALSL_0503	COG0789	Transcriptional regulator
ALSL_0505	COG0672	)-iron permease
ALSL_0511	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_0519	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALSL_0526	COG2132	Multicopper oxidase
ALSL_0530	COG0789	Transcriptional regulator
ALSL_0545	COG3311	Transcriptional regulator
ALSL_0546	COG1569	PIN domain
ALSL_0547	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALSL_0561	COG3039	Transposase
ALSL_0573	COG3039	Transposase
ALSL_0579	COG0789	Transcriptional regulator
ALSL_0587	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALSL_0589	COG0789	Transcriptional regulator
ALSL_0592	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ALSL_0593	COG0629	single-stranded DNA binding
ALSL_0606	COG0457	Tetratricopeptide repeat
ALSL_0609	COG0779	Required for maturation of 30S ribosomal subunits
ALSL_0610	COG0195	Participates in both transcription termination and antitermination
ALSL_0610	COG2251	uridine kinase activity
ALSL_0614	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALSL_0615	COG1185	polyribonucleotide nucleotidyltransferase activity
ALSL_0617	COG3243	poly(R)-hydroxyalkanoic acid synthase
ALSL_0618	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ALSL_0621	COG0071	Belongs to the small heat shock protein (HSP20) family
ALSL_0624	COG0604	alcohol dehydrogenase
ALSL_0630	COG2850	peptidyl-arginine hydroxylation
ALSL_0633	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ALSL_0634	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALSL_0635	COG0175	sulfate reduction
ALSL_0636	COG2046	Belongs to the sulfate adenylyltransferase family
ALSL_0636	COG0529	Catalyzes the synthesis of activated sulfate
ALSL_0638	COG1648	precorrin-2 dehydrogenase activity
ALSL_0638	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALSL_0644	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ALSL_0645	COG1561	YicC-like family, N-terminal region
ALSL_0646	COG0194	GDP metabolic process
ALSL_0647	COG1127	ABC transporter
ALSL_0648	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALSL_0652	COG2853	Lipoprotein
ALSL_0653	COG1758	RNA polymerase activity
ALSL_0654	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALSL_0656	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ALSL_0658	COG0254	rRNA binding
ALSL_0660	COG0372	Belongs to the citrate synthase family
ALSL_0664	COG2022	thiamine diphosphate biosynthetic process
ALSL_0671	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ALSL_0672	COG3278	Belongs to the heme-copper respiratory oxidase family
ALSL_0675	COG2010	Cytochrome c
ALSL_0679	COG2217	Heavy metal translocating P-type atpase
ALSL_0682	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ALSL_0684	COG0277	FAD linked oxidase domain protein
ALSL_0693	COG3483	tryptophan 2,3-dioxygenase activity
ALSL_0696	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ALSL_0700	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ALSL_0703	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_0709	COG1677	Flagellar hook-basal body complex protein FliE
ALSL_0711	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALSL_0720	COG1338	Plays a role in the flagellum-specific transport system
ALSL_0721	COG1987	bacterial-type flagellum assembly
ALSL_0724	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALSL_0728	COG0745	RESPONSE REGULATOR receiver
ALSL_0729	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ALSL_0730	COG0643	Histidine kinase
ALSL_0730	COG0784	Response regulator, receiver
ALSL_0730	COG2198	Histidine kinase
ALSL_0731	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ALSL_0732	COG1360	Flagellar Motor Protein
ALSL_0733	COG0835	chemotaxis
ALSL_0734	COG0842	Transport permease protein
ALSL_0735	COG1129	ABC transporter
ALSL_0735	COG0842	Transport permease protein
ALSL_0736	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_0738	COG4993	Dehydrogenase
ALSL_0741	COG2814	Major facilitator Superfamily
ALSL_0746	COG4771	TonB-dependent receptor
ALSL_0749	COG0643	Histidine kinase
ALSL_0749	COG2198	Histidine kinase
ALSL_0750	COG0835	chemotaxis
ALSL_0751	COG0840	transmembrane signaling receptor activity
ALSL_0752	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALSL_0753	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ALSL_0754	COG2201	protein-glutamate methylesterase activity
ALSL_0759	COG2080	2 iron, 2 sulfur cluster binding
ALSL_0761	COG0527	aspartate kinase activity
ALSL_0763	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALSL_0766	COG0729	surface antigen
ALSL_0769	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ALSL_0772	COG1368	sulfuric ester hydrolase activity
ALSL_0775	COG0783	Belongs to the Dps family
ALSL_0776	COG1643	Atp-dependent helicase
ALSL_0780	COG2855	membrane
ALSL_0781	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALSL_0797	COG1960	acyl-CoA dehydrogenase activity
ALSL_0800	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALSL_0803	COG0693	protein deglycase activity
ALSL_0804	COG3590	peptidase
ALSL_0808	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALSL_0810	COG0745	RESPONSE REGULATOR receiver
ALSL_0811	COG2205	protein histidine kinase activity
ALSL_0813	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ALSL_0813	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ALSL_0814	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ALSL_0817	COG0010	Belongs to the arginase family
ALSL_0818	COG2211	Major facilitator Superfamily
ALSL_0819	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALSL_0821	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALSL_0822	COG0071	Belongs to the small heat shock protein (HSP20) family
ALSL_0823	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ALSL_0824	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALSL_0827	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ALSL_0830	COG1137	ATPase activity
ALSL_0833	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ALSL_0836	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALSL_0839	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALSL_0842	COG0628	permease
ALSL_0844	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALSL_0845	COG3264	Mechanosensitive ion channel
ALSL_0845	COG1196	nuclear chromosome segregation
ALSL_0846	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALSL_0847	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALSL_0850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALSL_0855	COG1131	(ABC) transporter
ALSL_0856	COG2186	Transcriptional regulator
ALSL_0858	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ALSL_0861	COG2879	small protein
ALSL_0862	COG1966	Carbon starvation protein
ALSL_0864	COG1309	transcriptional regulator
ALSL_0870	COG4638	Rieske (2fe-2S)
ALSL_0871	COG4221	oxidoreductase activity
ALSL_0871	COG3321	synthase
ALSL_0871	COG0604	alcohol dehydrogenase
ALSL_0871	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ALSL_0872	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_0878	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALSL_0882	COG1802	Transcriptional regulator
ALSL_0883	COG4638	Rieske (2fe-2S)
ALSL_0884	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ALSL_0885	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_0886	COG0163	prenyltransferase activity
ALSL_0890	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_0903	COG0242	peptide deformylase activity
ALSL_0904	COG0284	orotidine-5'-phosphate decarboxylase activity
ALSL_0905	COG0488	(ABC) transporter
ALSL_0907	COG0483	inositol monophosphate 1-phosphatase activity
ALSL_0908	COG0494	nUDIX hydrolase
ALSL_0910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALSL_0910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALSL_0917	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ALSL_0922	COG0252	asparaginase activity
ALSL_0923	COG1960	acyl-CoA dehydrogenase activity
ALSL_0924	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_0927	COG1295	ribonuclease BN
ALSL_0928	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_0929	COG1254	Belongs to the acylphosphatase family
ALSL_0930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALSL_0933	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ALSL_0934	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALSL_0936	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALSL_0937	COG0193	aminoacyl-tRNA hydrolase activity
ALSL_0938	COG0012	GTP binding
ALSL_0939	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ALSL_0941	COG1946	Acyl-CoA thioesterase
ALSL_0944	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALSL_0944	COG0116	Belongs to the methyltransferase superfamily
ALSL_0946	COG0537	adenosine 5'-monophosphoramidase activity
ALSL_0949	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ALSL_0950	COG0386	Belongs to the glutathione peroxidase family
ALSL_0951	COG1047	Peptidyl-prolyl cis-trans
ALSL_0960	COG0714	Associated with various cellular activities
ALSL_0963	COG1399	metal-binding, possibly nucleic acid-binding protein
ALSL_0964	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALSL_0965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALSL_0969	COG1530	ribonuclease E activity
ALSL_0970	COG0564	pseudouridine synthase activity
ALSL_0971	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALSL_0973	COG3028	Belongs to the UPF0307 family
ALSL_0974	COG0312	modulator of DNA gyrase
ALSL_0976	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ALSL_0977	COG0539	negative regulation of cytoplasmic translation
ALSL_0978	COG0776	regulation of translation
ALSL_0979	COG1131	(ABC) transporter
ALSL_0983	COG1999	signal sequence binding
ALSL_0984	COG2363	Small membrane protein
ALSL_0989	COG0159	tryptophan synthase activity
ALSL_0990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALSL_0994	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALSL_0996	COG0735	belongs to the Fur family
ALSL_0998	COG1230	cation diffusion facilitator family transporter
ALSL_1006	COG3685	Protein conserved in bacteria
ALSL_1009	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_1010	COG1388	LysM domain
ALSL_1010	COG0741	lytic transglycosylase activity
ALSL_1011	COG0688	phosphatidylethanolamine metabolic process
ALSL_1012	COG2890	protein-(glutamine-N5) methyltransferase activity
ALSL_1014	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALSL_1015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALSL_1020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALSL_1022	COG0557	exoribonuclease II activity
ALSL_1023	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALSL_1025	COG0704	Plays a role in the regulation of phosphate uptake
ALSL_1028	COG0573	inorganic phosphate transmembrane transporter activity
ALSL_1029	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ALSL_1030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALSL_1032	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALSL_1033	COG2878	Part of a membrane complex involved in electron transport
ALSL_1035	COG2223	nitrite transmembrane transporter activity
ALSL_1036	COG1011	Hydrolase
ALSL_1037	COG1349	DNA-binding transcription factor activity
ALSL_1041	COG1555	photosystem II stabilization
ALSL_1044	COG0791	NLP P60 protein
ALSL_1046	COG1113	amino acid transport
ALSL_1047	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ALSL_1052	COG4774	siderophore transport
ALSL_1054	COG3590	peptidase
ALSL_1056	COG1183	phosphatidylcholine synthase activity
ALSL_1061	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALSL_1063	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_1064	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALSL_1065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_1067	COG0750	zinc metalloprotease
ALSL_1068	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ALSL_1069	COG0575	Belongs to the CDS family
ALSL_1070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALSL_1074	COG0052	Belongs to the universal ribosomal protein uS2 family
ALSL_1075	COG0024	Methionine aminopeptidase
ALSL_1076	COG1802	Transcriptional regulator
ALSL_1077	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALSL_1078	COG0346	lactoylglutathione lyase activity
ALSL_1079	COG0625	glutathione transferase activity
ALSL_1081	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALSL_1090	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_1094	COG4638	Rieske (2fe-2S)
ALSL_1095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ALSL_1096	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_1097	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_1098	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALSL_1099	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_1104	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ALSL_1105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALSL_1106	COG2171	N-acyltransferase activity
ALSL_1107	COG1393	Belongs to the ArsC family
ALSL_1108	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_1113	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ALSL_1114	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALSL_1116	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALSL_1117	COG4572	Cation transport regulator
ALSL_1119	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ALSL_1120	COG2894	cell division
ALSL_1124	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_1126	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ALSL_1133	COG2867	negative regulation of translational initiation
ALSL_1134	COG2914	Belongs to the UPF0125 (RnfH) family
ALSL_1135	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALSL_1136	COG0735	belongs to the Fur family
ALSL_1137	COG4585	Histidine kinase
ALSL_1140	COG1420	regulation of RNA biosynthetic process
ALSL_1141	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALSL_1142	COG0443	Heat shock 70 kDa protein
ALSL_1144	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ALSL_1147	COG0505	Belongs to the CarA family
ALSL_1148	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALSL_1149	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_1150	COG0481	GTPase activity
ALSL_1151	COG0681	Belongs to the peptidase S26 family
ALSL_1155	COG1381	Involved in DNA repair and RecF pathway recombination
ALSL_1159	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALSL_1160	COG2954	triphosphatase activity
ALSL_1161	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_1163	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ALSL_1164	COG1278	Cold shock
ALSL_1165	COG0475	glutathione-regulated potassium exporter activity
ALSL_1167	COG4585	Histidine kinase
ALSL_1168	COG2197	response regulator
ALSL_1171	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALSL_1172	COG0740	serine-type endopeptidase activity
ALSL_1173	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALSL_1175	COG0776	regulation of translation
ALSL_1178	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALSL_1179	COG1388	LysM domain
ALSL_1179	COG0791	NLP P60 protein
ALSL_1182	COG0328	RNA-DNA hybrid ribonuclease activity
ALSL_1183	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALSL_1187	COG0477	Major facilitator Superfamily
ALSL_1190	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ALSL_1191	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_1192	COG2166	iron-sulfur cluster assembly
ALSL_1196	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALSL_1198	COG0137	argininosuccinate synthase activity
ALSL_1199	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_1200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ALSL_1203	COG0165	Argininosuccinate lyase
ALSL_1205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALSL_1206	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALSL_1207	COG3844	kynureninase activity
ALSL_1210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALSL_1214	COG2153	protein acetylation
ALSL_1216	COG1228	amidohydrolase
ALSL_1220	COG1132	(ABC) transporter
ALSL_1222	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALSL_1226	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ALSL_1227	COG2132	Multicopper oxidase
ALSL_1228	COG3667	copper resistance
ALSL_1230	COG5002	protein histidine kinase activity
ALSL_1230	COG5001	Diguanylate cyclase
ALSL_1231	COG2982	Protein involved in outer membrane biogenesis
ALSL_1232	COG1764	response to oxidative stress
ALSL_1235	COG0384	phenazine biosynthesis protein PhzF
ALSL_1239	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALSL_1240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALSL_1244	COG1063	alcohol dehydrogenase
ALSL_1246	COG1923	regulation of RNA biosynthetic process
ALSL_1247	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ALSL_1251	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_1253	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_1257	COG1196	nuclear chromosome segregation
ALSL_1257	COG3264	Mechanosensitive ion channel
ALSL_1258	COG1515	deoxyribonuclease V activity
ALSL_1265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALSL_1267	COG2813	Specifically methylates the guanine in position
ALSL_1268	COG1187	pseudouridine synthase activity
ALSL_1277	COG3039	Transposase
ALSL_1279	COG0784	Response regulator, receiver
ALSL_1279	COG4191	Histidine kinase
ALSL_1281	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALSL_1287	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_1289	COG0142	geranyltranstransferase activity
ALSL_1290	COG1722	exodeoxyribonuclease VII activity
ALSL_1292	COG0825	malonyl-CoA metabolic process
ALSL_1293	COG1619	proteins homologs of microcin C7 resistance protein MccF
ALSL_1294	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALSL_1295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALSL_1297	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ALSL_1299	COG0753	catalase activity
ALSL_1302	COG0824	Thioesterase
ALSL_1303	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALSL_1305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALSL_1306	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALSL_1309	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALSL_1310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_1312	COG3265	gluconokinase activity
ALSL_1314	COG2833	Protein of unknown function (DUF455)
ALSL_1317	COG2986	histidine ammonia-lyase
ALSL_1321	COG0406	alpha-ribazole phosphatase activity
ALSL_1322	COG0285	dihydrofolate synthase activity
ALSL_1327	COG0316	Belongs to the HesB IscA family
ALSL_1327	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ALSL_1331	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_1332	COG2957	Belongs to the agmatine deiminase family
ALSL_1334	COG0488	(ABC) transporter
ALSL_1336	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALSL_1338	COG0367	asparagine synthase
ALSL_1340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ALSL_1343	COG2350	Protein conserved in bacteria
ALSL_1349	COG0305	Participates in initiation and elongation during chromosome replication
ALSL_1351	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_1352	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALSL_1354	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALSL_1356	COG0745	RESPONSE REGULATOR receiver
ALSL_1357	COG4783	chaperone-mediated protein folding
ALSL_1358	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ALSL_1360	COG0473	3-isopropylmalate dehydrogenase activity
ALSL_1362	COG0351	phosphomethylpyrimidine kinase
ALSL_1362	COG0352	thiamine-phosphate diphosphorylase activity
ALSL_1363	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALSL_1364	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALSL_1366	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALSL_1368	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ALSL_1378	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALSL_1379	COG0360	Binds together with S18 to 16S ribosomal RNA
ALSL_1380	COG0316	Belongs to the HesB IscA family
ALSL_1384	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_1385	COG0288	reversible hydration of carbon dioxide
ALSL_1387	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALSL_1388	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALSL_1389	COG0791	NLP P60 protein
ALSL_1391	COG2814	Major facilitator Superfamily
ALSL_1395	COG4221	oxidoreductase activity
ALSL_1397	COG0529	Catalyzes the synthesis of activated sulfate
ALSL_1397	COG2895	sulfate adenylyltransferase (ATP) activity
ALSL_1398	COG0175	sulfate reduction
ALSL_1400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALSL_1401	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALSL_1402	COG0719	Fe-S assembly protein
ALSL_1403	COG0396	ATPase activity
ALSL_1405	COG0719	Fe-S assembly protein
ALSL_1407	COG0347	Belongs to the P(II) protein family
ALSL_1408	COG0004	ammonium transporteR
ALSL_1409	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALSL_1411	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALSL_1412	COG1360	Flagellar Motor Protein
ALSL_1415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALSL_1416	COG1862	Preprotein translocase
ALSL_1419	COG2835	tetraacyldisaccharide 4'-kinase activity
ALSL_1424	COG2814	Major facilitator Superfamily
ALSL_1425	COG0579	oxidoreductase
ALSL_1426	COG2969	positive regulation of protein catabolic process
ALSL_1427	COG0625	glutathione transferase activity
ALSL_1428	COG2857	Cytochrome c1
ALSL_1429	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ALSL_1430	COG0723	plastoquinol--plastocyanin reductase activity
ALSL_1431	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_1433	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALSL_1433	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALSL_1436	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ALSL_1437	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALSL_1439	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ALSL_1442	COG0784	Response regulator, receiver
ALSL_1442	COG0643	Histidine kinase
ALSL_1442	COG2198	Histidine kinase
ALSL_1442	COG0784	Response regulator, receiver
ALSL_1442	COG0643	Histidine kinase
ALSL_1442	COG2198	Histidine kinase
ALSL_1443	COG0840	transmembrane signaling receptor activity
ALSL_1447	COG0189	ligase activity
ALSL_1451	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALSL_1458	COG0762	integral membrane protein
ALSL_1459	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALSL_1461	COG0732	type I restriction modification DNA specificity domain
ALSL_1463	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ALSL_1465	COG0432	Pfam Uncharacterised protein family UPF0047
ALSL_1467	COG0572	uridine kinase
ALSL_1469	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALSL_1471	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_1474	COG1914	H( )-stimulated, divalent metal cation uptake system
ALSL_1476	COG0343	queuine tRNA-ribosyltransferase activity
ALSL_1477	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALSL_1478	COG2197	response regulator
ALSL_1479	COG4585	Histidine kinase
ALSL_1481	COG1131	(ABC) transporter
ALSL_1484	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ALSL_1487	COG0277	FAD linked oxidase domain protein
ALSL_1488	COG0415	Belongs to the DNA photolyase family
ALSL_1489	COG3300	MHYT domain
ALSL_1489	COG5001	Diguanylate cyclase
ALSL_1491	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALSL_1494	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_1498	COG3023	N-Acetylmuramoyl-L-alanine amidase
ALSL_1500	COG3273	potassium ion transport
ALSL_1500	COG0471	metal ion transport
ALSL_1504	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALSL_1504	COG2169	Transcriptional regulator
ALSL_1505	COG0697	spore germination
ALSL_1508	COG2132	Multicopper oxidase
ALSL_1513	COG0697	spore germination
ALSL_1514	COG2031	fatty acid transporter
ALSL_1519	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_1519	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALSL_1521	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALSL_1523	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ALSL_1525	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALSL_1530	COG0105	UTP biosynthetic process
ALSL_1532	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALSL_1532	COG1024	Enoyl-CoA hydratase
ALSL_1533	COG0183	Belongs to the thiolase family
ALSL_1536	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALSL_1538	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALSL_1548	COG0582	viral genome integration into host DNA
ALSL_1550	COG1286	toxin biosynthetic process
ALSL_1552	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ALSL_1553	COG0489	protein tyrosine kinase activity
ALSL_1555	COG4535	Mg2 and Co2 transporter CorC
ALSL_1557	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALSL_1559	COG1702	phosphate starvation-inducible protein PhoH
ALSL_1560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALSL_1566	COG2076	Multidrug Resistance protein
ALSL_1570	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALSL_1571	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ALSL_1575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALSL_1576	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ALSL_1578	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALSL_1581	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_1589	COG0625	glutathione transferase activity
ALSL_1590	COG1960	acyl-CoA dehydrogenase activity
ALSL_1591	COG0697	spore germination
ALSL_1594	COG0028	Belongs to the TPP enzyme family
ALSL_1597	COG0477	Major facilitator Superfamily
ALSL_1602	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALSL_1606	COG0717	Belongs to the dCTP deaminase family
ALSL_1607	COG1674	ftsk spoiiie
ALSL_1608	COG0686	Belongs to the AlaDH PNT family
ALSL_1609	COG0492	ferredoxin-NADP+ reductase activity
ALSL_1611	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALSL_1619	COG3706	GGDEF domain
ALSL_1623	COG4191	Histidine kinase
ALSL_1623	COG0784	Response regulator, receiver
ALSL_1625	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_1627	COG0039	L-malate dehydrogenase activity
ALSL_1629	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALSL_1634	COG2198	Histidine kinase
ALSL_1634	COG2205	protein histidine kinase activity
ALSL_1634	COG0784	Response regulator, receiver
ALSL_1636	COG4771	TonB-dependent receptor
ALSL_1637	COG2610	gluconate transmembrane transporter activity
ALSL_1639	COG1609	Transcriptional regulator
ALSL_1642	COG0667	Aldo Keto reductase
ALSL_1643	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALSL_1649	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALSL_1650	COG1546	Belongs to the CinA family
ALSL_1655	COG0861	Integral membrane protein TerC family
ALSL_1657	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ALSL_1660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_1662	COG3384	dioxygenase
ALSL_1664	COG1297	OPT oligopeptide transporter protein
ALSL_1665	COG1132	(ABC) transporter
ALSL_1668	COG1640	4-alpha-glucanotransferase
ALSL_1669	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ALSL_1671	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ALSL_1672	COG0366	Alpha amylase catalytic
ALSL_1673	COG0366	Alpha amylase catalytic
ALSL_1676	COG0167	dihydroorotate dehydrogenase activity
ALSL_1677	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALSL_1681	COG0577	efflux transmembrane transporter activity
ALSL_1682	COG1136	(ABC) transporter
ALSL_1683	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_1684	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALSL_1685	COG1970	mechanosensitive ion channel activity
ALSL_1692	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALSL_1693	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALSL_1695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALSL_1696	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ALSL_1701	COG0556	nucleotide-excision repair
ALSL_1704	COG1611	Belongs to the LOG family
ALSL_1707	COG2095	MarC family integral membrane protein
ALSL_1712	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ALSL_1713	COG0237	dephospho-CoA kinase activity
ALSL_1714	COG5002	protein histidine kinase activity
ALSL_1714	COG5000	phosphorelay sensor kinase activity
ALSL_1715	COG0745	RESPONSE REGULATOR receiver
ALSL_1717	COG4181	ATPase activity
ALSL_1719	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALSL_1721	COG3956	TIGRFAM MazG family protein
ALSL_1722	COG0442	prolyl-tRNA aminoacylation
ALSL_1726	COG0330	HflC and HflK could
ALSL_1727	COG0366	Alpha amylase catalytic
ALSL_1732	COG0047	phosphoribosylformylglycinamidine synthase activity
ALSL_1732	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALSL_1733	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ALSL_1734	COG4974	Belongs to the 'phage' integrase family
ALSL_1738	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ALSL_1739	COG0602	queuosine metabolic process
ALSL_1741	COG2885	chlorophyll binding
ALSL_1744	COG0848	biopolymer transport protein
ALSL_1746	COG0824	Thioesterase
ALSL_1747	COG2255	four-way junction helicase activity
ALSL_1751	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALSL_1752	COG0402	S-adenosylhomocysteine deaminase activity
ALSL_1753	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALSL_1754	COG1509	lysine 2,3-aminomutase activity
ALSL_1758	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALSL_1760	COG1469	GTP cyclohydrolase I activity
ALSL_1765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ALSL_1768	COG0196	riboflavin kinase activity
ALSL_1769	COG0728	peptidoglycan biosynthetic process
ALSL_1771	COG1960	acyl-CoA dehydrogenase activity
ALSL_1774	COG0646	methionine synthase
ALSL_1774	COG1410	methionine synthase
ALSL_1775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_1775	COG3952	Lipid A Biosynthesis
ALSL_1784	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_1785	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_1788	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ALSL_1789	COG1187	pseudouridine synthase activity
ALSL_1790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_1791	COG0436	Aminotransferase
ALSL_1797	COG3642	lipopolysaccharide core region biosynthetic process
ALSL_1798	COG0859	PFAM glycosyl transferase family 9
ALSL_1800	COG0477	Major facilitator Superfamily
ALSL_1801	COG3039	Transposase
ALSL_1803	COG0336	Belongs to the RNA methyltransferase TrmD family
ALSL_1804	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALSL_1805	COG0228	four-way junction DNA binding
ALSL_1806	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALSL_1807	COG4137	Cytochrome C assembly protein
ALSL_1812	COG0545	Peptidyl-prolyl cis-trans isomerase
ALSL_1813	COG1024	Enoyl-CoA hydratase
ALSL_1815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ALSL_1817	COG0802	atpase or kinase
ALSL_1818	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALSL_1818	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALSL_1821	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALSL_1822	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALSL_1823	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ALSL_1824	COG2925	Exonuclease
ALSL_1829	COG1703	isobutyryl-CoA mutase activity
ALSL_1829	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALSL_1829	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALSL_1832	COG1960	acyl-CoA dehydrogenase activity
ALSL_1833	COG0183	Belongs to the thiolase family
ALSL_1836	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ALSL_1840	COG1024	Enoyl-CoA hydratase
ALSL_1850	COG4638	Rieske (2fe-2S)
ALSL_1851	COG1007	ATP synthesis coupled electron transport
ALSL_1854	COG0713	ATP synthesis coupled electron transport
ALSL_1855	COG0839	Belongs to the complex I subunit 6 family
ALSL_1858	COG1034	ATP synthesis coupled electron transport
ALSL_1859	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ALSL_1860	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ALSL_1861	COG0649	NAD binding
ALSL_1862	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_1863	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_1864	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_1865	COG1215	transferase activity, transferring glycosyl groups
ALSL_1866	COG0326	Molecular chaperone. Has ATPase activity
ALSL_1867	COG0501	Belongs to the peptidase M48B family
ALSL_1868	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALSL_1869	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_1870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ALSL_1871	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ALSL_1872	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALSL_1873	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ALSL_1874	COG0148	phosphopyruvate hydratase activity
ALSL_1876	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALSL_1880	COG0662	Cupin 2, conserved barrel domain protein
ALSL_1882	COG0531	amino acid
ALSL_1883	COG0531	amino acid
ALSL_1886	COG0235	Class ii aldolase
ALSL_1887	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ALSL_1888	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ALSL_1890	COG0140	phosphoribosyl-ATP diphosphatase activity
ALSL_1890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALSL_1892	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALSL_1894	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALSL_1894	COG0131	Imidazoleglycerol-phosphate dehydratase
ALSL_1895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALSL_1896	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALSL_1897	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALSL_1899	COG1663	tetraacyldisaccharide 4'-kinase activity
ALSL_1900	COG1132	(ABC) transporter
ALSL_1902	COG0811	peptide transport
ALSL_1903	COG0658	competence protein
ALSL_1903	COG2333	competence protein COMEC
ALSL_1905	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALSL_1908	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALSL_1910	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ALSL_1911	COG2009	succinate dehydrogenase
ALSL_1913	COG0354	folic acid binding
ALSL_1921	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALSL_1925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALSL_1929	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_1932	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALSL_1935	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALSL_1936	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ALSL_1938	COG0617	tRNA 3'-terminal CCA addition
ALSL_1940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALSL_1941	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALSL_1945	COG0300	oxidoreductase activity
ALSL_1946	COG0149	triose-phosphate isomerase activity
ALSL_1947	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALSL_1949	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALSL_1951	COG1064	alcohol dehydrogenase
ALSL_1953	COG2366	antibiotic biosynthetic process
ALSL_1954	COG1024	Enoyl-CoA hydratase
ALSL_1954	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALSL_1956	COG2900	Belongs to the SlyX family
ALSL_1958	COG0545	Peptidyl-prolyl cis-trans isomerase
ALSL_1959	COG4651	solute:proton antiporter activity
ALSL_1959	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALSL_1967	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALSL_1968	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ALSL_1971	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ALSL_1979	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALSL_1980	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ALSL_1981	COG1534	Rna-binding protein
ALSL_1985	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALSL_1991	COG1902	pentaerythritol trinitrate reductase activity
ALSL_1993	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALSL_1993	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALSL_1996	COG0330	HflC and HflK could
ALSL_1997	COG0330	HflC and HflK could
ALSL_1998	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ALSL_2002	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALSL_2004	COG2010	Cytochrome c
ALSL_2006	COG0154	amidase activity
ALSL_2007	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ALSL_2008	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ALSL_2009	COG0203	ribosomal protein L17
ALSL_2010	COG0202	RNA polymerase activity
ALSL_2011	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALSL_2012	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALSL_2013	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALSL_2014	COG0201	protein transport
ALSL_2017	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALSL_2018	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALSL_2020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALSL_2021	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALSL_2022	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALSL_2023	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALSL_2027	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALSL_2028	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALSL_2029	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALSL_2030	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALSL_2031	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALSL_2032	COG0089	rRNA binding
ALSL_2034	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALSL_2035	COG0051	transcription antitermination factor activity, RNA binding
ALSL_2036	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALSL_2040	COG0049	tRNA binding
ALSL_2041	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALSL_2042	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALSL_2043	COG0085	RNA polymerase activity
ALSL_2044	COG0222	ribosome binding
ALSL_2045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALSL_2046	COG0081	regulation of translation
ALSL_2047	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALSL_2048	COG0250	Participates in transcription elongation, termination and antitermination
ALSL_2049	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALSL_2051	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALSL_2060	COG3387	PFAM Glycoside hydrolase 15-related
ALSL_2061	COG3158	transport of potassium into the cell
ALSL_2062	COG0632	four-way junction helicase activity
ALSL_2066	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALSL_2069	COG4206	TonB-dependent receptor
ALSL_2070	COG0542	response to heat
ALSL_2071	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ALSL_2073	COG1355	regulation of microtubule-based process
ALSL_2074	COG2078	PFAM AMMECR1 domain protein
ALSL_2082	COG0531	amino acid
ALSL_2094	COG0352	thiamine-phosphate diphosphorylase activity
ALSL_2095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALSL_2098	COG0346	lactoylglutathione lyase activity
ALSL_2099	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALSL_2100	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_2101	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALSL_2102	COG0563	adenylate kinase activity
ALSL_2104	COG0840	transmembrane signaling receptor activity
ALSL_2105	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ALSL_2106	COG1505	serine-type exopeptidase activity
ALSL_2108	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ALSL_2114	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALSL_2115	COG1538	Outer membrane efflux protein
ALSL_2116	COG1519	Transferase
ALSL_2126	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALSL_2130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ALSL_2138	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALSL_2143	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALSL_2149	COG0494	nUDIX hydrolase
ALSL_2156	COG1704	LemA family
ALSL_2157	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ALSL_2160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ALSL_2163	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALSL_2165	COG0542	response to heat
ALSL_2166	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ALSL_2168	COG0482	sulfurtransferase activity
ALSL_2169	COG2915	High frequency lysogenization protein hflD homolog
ALSL_2172	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALSL_2173	COG0667	Aldo Keto reductase
ALSL_2174	COG0312	modulator of DNA gyrase
ALSL_2176	COG1530	ribonuclease E activity
ALSL_2181	COG2205	protein histidine kinase activity
ALSL_2182	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ALSL_2184	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ALSL_2185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ALSL_2187	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALSL_2190	COG0495	leucyl-tRNA aminoacylation
ALSL_2192	COG3008	intermembrane lipid transfer
ALSL_2193	COG2995	paraquat-inducible protein a
ALSL_2194	COG2995	paraquat-inducible protein a
ALSL_2200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALSL_2201	COG1074	ATP-dependent DNA helicase activity
ALSL_2202	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ALSL_2203	COG3161	chorismate lyase activity
ALSL_2205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALSL_2208	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALSL_2211	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALSL_2216	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALSL_2216	COG1372	Participates in initiation and elongation during chromosome replication
ALSL_2217	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_2219	COG0546	phosphoglycolate phosphatase activity
ALSL_2220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALSL_2222	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_2229	COG0493	'glutamate synthase
ALSL_2230	COG0069	glutamate synthase activity
ALSL_2230	COG0070	glutamate synthase
ALSL_2230	COG0067	glutamate synthase
ALSL_2232	COG4942	peptidase
ALSL_2233	COG0793	Belongs to the peptidase S41A family
ALSL_2236	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALSL_2238	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALSL_2239	COG0596	Alpha beta hydrolase
ALSL_2240	COG1668	transmembrane transport
ALSL_2241	COG4555	ABC transporter
ALSL_2244	COG3121	Chaperone
ALSL_2245	COG3188	usher protein
ALSL_2248	COG1131	(ABC) transporter
ALSL_2249	COG0842	Transport permease protein
ALSL_2250	COG0477	Major facilitator Superfamily
ALSL_2255	COG1643	Atp-dependent helicase
ALSL_2256	COG0793	Belongs to the peptidase S41A family
ALSL_2257	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ALSL_2258	COG0321	lipoyl(octanoyl) transferase activity
ALSL_2259	COG2921	Belongs to the UPF0250 family
ALSL_2260	COG1686	Belongs to the peptidase S11 family
ALSL_2262	COG2951	lytic endotransglycosylase activity
ALSL_2263	COG0772	Belongs to the SEDS family
ALSL_2264	COG0768	penicillin binding
ALSL_2266	COG1792	Involved in formation and maintenance of cell shape
ALSL_2267	COG1077	Cell shape determining protein MreB Mrl
ALSL_2269	COG0006	proline dipeptidase activity
ALSL_2272	COG1294	oxidase, subunit
ALSL_2274	COG0006	proline dipeptidase activity
ALSL_2278	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALSL_2281	COG0025	NhaP-type Na H and K H
ALSL_2283	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALSL_2285	COG0247	lactate metabolic process
ALSL_2286	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ALSL_2287	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ALSL_2288	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_2291	COG0134	indole-3-glycerol-phosphate synthase activity
ALSL_2292	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALSL_2294	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ALSL_2297	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ALSL_2298	COG1877	trehalose-phosphatase activity
ALSL_2299	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ALSL_2300	COG0564	pseudouridine synthase activity
ALSL_2302	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALSL_2302	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_2304	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ALSL_2309	COG0784	Response regulator, receiver
ALSL_2310	COG4251	negative regulation of phosphorylation
ALSL_2311	COG0629	single-stranded DNA binding
ALSL_2312	COG2814	Major facilitator Superfamily
ALSL_2313	COG0142	geranyltranstransferase activity
ALSL_2315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_2316	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_2318	COG2096	Adenosyltransferase
ALSL_2320	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ALSL_2321	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALSL_2322	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALSL_2323	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALSL_2325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALSL_2328	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALSL_2331	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ALSL_2332	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALSL_2336	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALSL_2337	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALSL_2340	COG3116	cell division
ALSL_2341	COG0275	rRNA processing
ALSL_2343	COG0431	NADPH-dependent FMN reductase
ALSL_2344	COG1393	Belongs to the ArsC family
ALSL_2346	COG0037	tRNA processing
ALSL_2349	COG0612	Peptidase, M16
ALSL_2351	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ALSL_2353	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALSL_2354	COG0564	pseudouridine synthase activity
ALSL_2358	COG0583	DNA-binding transcription factor activity
ALSL_2359	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ALSL_2360	COG2224	Isocitrate lyase
ALSL_2361	COG0606	chelatase, subunit chli
ALSL_2364	COG0588	phosphoglycerate mutase activity
ALSL_2365	COG3038	cytochrome b561
ALSL_2366	COG0408	coproporphyrinogen oxidase activity
ALSL_2371	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ALSL_2372	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALSL_2374	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALSL_2376	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALSL_2378	COG0356	it plays a direct role in the translocation of protons across the membrane
ALSL_2381	COG0730	response to heat
ALSL_2382	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALSL_2389	COG0625	glutathione transferase activity
ALSL_2390	COG0126	phosphoglycerate kinase activity
ALSL_2394	COG3588	fructose-bisphosphate aldolase
ALSL_2397	COG4786	Flagellar basal body rod
ALSL_2398	COG1705	Flagellar rod assembly protein muramidase FlgJ
ALSL_2398	COG3951	Flagellar rod assembly protein muramidase FlgJ
ALSL_2400	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ALSL_2403	COG1749	Flagellar hook protein flgE
ALSL_2404	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ALSL_2406	COG1815	bacterial-type flagellum-dependent cell motility
ALSL_2413	COG0405	Gamma-glutamyltransferase
ALSL_2414	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALSL_2416	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALSL_2417	COG0742	ribosomal rna small subunit methyltransferase
ALSL_2418	COG0552	protein localization to endoplasmic reticulum
ALSL_2420	COG1194	a g-specific adenine glycosylase
ALSL_2421	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ALSL_2426	COG2856	Zn peptidase
ALSL_2448	COG3609	addiction module antidote protein, CC2985 family
ALSL_2453	COG2856	Zn peptidase
ALSL_2494	COG3609	addiction module antidote protein, CC2985 family
ALSL_2497	COG1902	pentaerythritol trinitrate reductase activity
ALSL_2501	COG0514	ATP-dependent DNA helicase (RecQ)
ALSL_2505	COG1566	PFAM secretion protein HlyD family protein
ALSL_2509	COG0306	phosphate transporter
ALSL_2511	COG1253	flavin adenine dinucleotide binding
ALSL_2512	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ALSL_2516	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALSL_2519	COG1560	Kdo2-lipid A biosynthetic process
ALSL_2524	COG2353	YceI-like domain
ALSL_2527	COG1285	pathogenesis
ALSL_2529	COG1368	sulfuric ester hydrolase activity
ALSL_2532	COG1566	PFAM secretion protein HlyD family protein
ALSL_2537	COG1324	tolerance protein
ALSL_2538	COG4232	protein-disulfide reductase activity
ALSL_2539	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_2544	COG0625	glutathione transferase activity
ALSL_2545	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_2546	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_2548	COG0625	glutathione transferase activity
ALSL_2550	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_2552	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ALSL_2554	COG2937	Belongs to the GPAT DAPAT family
ALSL_2556	COG2226	methyltransferase
ALSL_2558	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_2561	COG0457	Tetratricopeptide repeat
ALSL_2562	COG2188	Transcriptional regulator
ALSL_2563	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ALSL_2564	COG0363	glucosamine-6-phosphate deaminase activity
ALSL_2565	COG0129	dihydroxy-acid dehydratase activity
ALSL_2566	COG0800	Aldolase
ALSL_2567	COG0084	hydrolase, TatD family'
ALSL_2568	COG3227	Zinc metalloprotease (Elastase)
ALSL_2570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALSL_2571	COG1459	type II secretion system
ALSL_2572	COG2165	general secretion pathway protein
ALSL_2574	COG2165	general secretion pathway protein
ALSL_2576	COG3156	type II secretion system protein K
ALSL_2577	COG3166	PFAM Fimbrial assembly family protein
ALSL_2580	COG1450	Type ii and iii secretion system protein
ALSL_2581	COG1199	ATP-dependent helicase activity
ALSL_2582	COG5001	Diguanylate cyclase
ALSL_2582	COG3300	MHYT domain
ALSL_2588	COG0471	metal ion transport
ALSL_2588	COG3273	potassium ion transport
ALSL_2592	COG0181	hydroxymethylbilane synthase activity
ALSL_2594	COG3275	phosphorelay sensor kinase activity
ALSL_2596	COG1506	peptidase
ALSL_2596	COG4946	Tricorn protease homolog
ALSL_2596	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_2598	COG0640	Transcriptional regulator
ALSL_2599	COG3453	Protein conserved in bacteria
ALSL_2599	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALSL_2605	COG1566	PFAM secretion protein HlyD family protein
ALSL_2606	COG2814	Major facilitator Superfamily
ALSL_2608	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ALSL_2610	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_2612	COG0673	inositol 2-dehydrogenase activity
ALSL_2614	COG0616	signal peptide processing
ALSL_2616	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALSL_2618	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_2620	COG2205	protein histidine kinase activity
ALSL_2622	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALSL_2623	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALSL_2624	COG2201	protein-glutamate methylesterase activity
ALSL_2625	COG2177	Part of the ABC transporter FtsEX involved in
ALSL_2626	COG2884	Cell division ATP-binding protein ftsE
ALSL_2630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ALSL_2634	COG0339	signal peptide processing
ALSL_2636	COG1956	GAF domain-containing protein
ALSL_2637	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALSL_2643	COG0741	lytic transglycosylase activity
ALSL_2645	COG0617	tRNA 3'-terminal CCA addition
ALSL_2652	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ALSL_2659	COG0395	ABC-type sugar transport system, permease component
ALSL_2660	COG1175	transmembrane transport
ALSL_2662	COG3664	PFAM glycoside hydrolase family 39
ALSL_2666	COG1609	Transcriptional regulator
ALSL_2668	COG0357	Ribosomal RNA small subunit methyltransferase G
ALSL_2669	COG1192	Involved in chromosome partitioning
ALSL_2670	COG1475	DNA binding
ALSL_2671	COG0463	Glycosyl transferase, family 2
ALSL_2672	COG3189	MarR family transcriptional regulator
ALSL_2674	COG3039	Transposase
ALSL_2678	COG0456	acetyltransferase
ALSL_2681	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALSL_2684	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ALSL_2688	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALSL_2689	COG1869	D-ribose catabolic process
ALSL_2690	COG1129	ABC transporter
ALSL_2691	COG1172	Belongs to the binding-protein-dependent transport system permease family
ALSL_2692	COG1879	ABC-type sugar transport system periplasmic component
ALSL_2694	COG4214	carbohydrate transport
ALSL_2695	COG1129	ABC transporter
ALSL_2696	COG4213	ABC transporter substrate-binding protein
ALSL_2697	COG1070	Carbohydrate kinase
ALSL_2699	COG1609	Transcriptional regulator
ALSL_2699	COG2207	Transcriptional regulator
ALSL_2700	COG2017	converts alpha-aldose to the beta-anomer
ALSL_2701	COG2376	Dihydroxyacetone kinase
ALSL_2702	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALSL_2703	COG0706	membrane insertase activity
ALSL_2705	COG0230	Belongs to the bacterial ribosomal protein bL34 family