locus-tag	class	description
ACT75_00005	COG1129	ABC transporter
ACT75_00005	COG0842	Transport permease protein
ACT75_00025	COG0308	aminopeptidase N
ACT75_00030	COG0167	dihydroorotate dehydrogenase activity
ACT75_00035	COG0613	PHP domain protein
ACT75_00045	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
ACT75_00050	COG0589	response to stress
ACT75_00055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACT75_00060	COG1528	Iron-storage protein
ACT75_00065	COG1528	Iron-storage protein
ACT75_00180	COG2925	Exonuclease
ACT75_00185	COG0697	spore germination
ACT75_00190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACT75_00195	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
ACT75_00200	COG0318	PFAM AMP-dependent synthetase and ligase
ACT75_00200	COG0204	Acyl-transferase
ACT75_00205	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
ACT75_00210	COG1686	Belongs to the peptidase S11 family
ACT75_00220	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACT75_00225	COG0586	Pfam SNARE associated Golgi protein
ACT75_00230	COG0058	SHG alpha-glucan phosphorylase activity
ACT75_00245	COG1523	belongs to the glycosyl hydrolase 13 family
ACT75_00285	COG3657	addiction module killer protein
ACT75_00300	COG1346	cytolysis
ACT75_00355	COG3005	denitrification pathway
ACT75_00360	COG0243	molybdopterin cofactor binding
ACT75_00365	COG2315	Protein conserved in bacteria
ACT75_00370	COG0471	metal ion transport
ACT75_00385	COG0101	tRNA pseudouridine synthase activity
ACT75_00405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACT75_00410	COG1074	ATP-dependent DNA helicase activity
ACT75_00415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACT75_00425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACT75_00430	COG1067	ATP-dependent peptidase activity
ACT75_00440	COG1278	Cold shock
ACT75_00455	COG3098	single-species biofilm formation
ACT75_00460	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
ACT75_00490	COG2801	Transposase and inactivated derivatives
ACT75_00495	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT75_00510	COG1178	ABC-type Fe3 transport system permease component
ACT75_00515	COG3842	ATPase activity
ACT75_00520	COG3101	peptidyl-lysine hydroxylation
ACT75_00525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACT75_00535	COG0788	formyltetrahydrofolate deformylase activity
ACT75_00540	COG2916	Histone family protein nucleoid-structuring protein H-NS
ACT75_00545	COG1757	Na H antiporter
ACT75_00560	COG0251	oxidation-reduction process
ACT75_00570	COG0463	Glycosyl transferase, family 2
ACT75_00575	COG3021	interspecies interaction between organisms
ACT75_00580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACT75_00590	COG1560	Kdo2-lipid A biosynthetic process
ACT75_00595	COG0730	response to heat
ACT75_00600	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
ACT75_00605	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACT75_00610	COG3264	Mechanosensitive ion channel
ACT75_00610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
ACT75_00615	COG0318	PFAM AMP-dependent synthetase and ligase
ACT75_00620	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
ACT75_00625	COG0596	Alpha beta hydrolase
ACT75_00630	COG0716	FMN binding
ACT75_00635	COG0735	belongs to the Fur family
ACT75_00640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACT75_00645	COG3094	Invasion gene expression up-regulator, SirB
ACT75_00650	COG0023	Translation Initiation Factor
ACT75_00660	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACT75_00665	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
ACT75_00670	COG0776	regulation of translation
ACT75_00675	COG0539	negative regulation of cytoplasmic translation
ACT75_00685	COG2990	Protein conserved in bacteria
ACT75_00690	COG4771	TonB-dependent receptor
ACT75_00695	COG0612	Peptidase, M16
ACT75_00700	COG1687	branched-chain amino acid
ACT75_00705	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACT75_00710	COG0583	DNA-binding transcription factor activity
ACT75_00720	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ACT75_00725	COG1518	maintenance of DNA repeat elements
ACT75_00770	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
ACT75_00775	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACT75_00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACT75_00795	COG0405	Gamma-glutamyltransferase
ACT75_00805	COG0745	RESPONSE REGULATOR receiver
ACT75_00810	COG0745	RESPONSE REGULATOR receiver
ACT75_00825	COG0737	Belongs to the 5'-nucleotidase family
ACT75_00830	COG4607	ABC-type enterochelin transport system periplasmic component
ACT75_00835	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT75_00840	COG4605	iron ion homeostasis
ACT75_00845	COG4604	ABC transporter, ATP-binding protein
ACT75_00850	COG0739	heme binding
ACT75_00860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT75_00865	COG0733	neurotransmitter:sodium symporter activity
ACT75_00870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACT75_00900	COG4657	Part of a membrane complex involved in electron transport
ACT75_00905	COG1090	epimerase
ACT75_00910	COG1438	arginine binding
ACT75_00915	COG0039	L-malate dehydrogenase activity
ACT75_00925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACT75_00930	COG0583	DNA-binding transcription factor activity
ACT75_00940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACT75_00945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACT75_00945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACT75_00950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACT75_00960	COG0471	metal ion transport
ACT75_00965	COG2005	Transcriptional regulator
ACT75_00970	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACT75_00975	COG4149	molybdate abc transporter
ACT75_00980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACT75_00990	COG0795	lipopolysaccharide-transporting ATPase activity
ACT75_00995	COG0795	lipopolysaccharide-transporting ATPase activity
ACT75_01000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACT75_01005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACT75_01035	COG0309	Hydrogenase expression formation protein (HypE)
ACT75_01040	COG0409	Hydrogenase expression formation protein
ACT75_01045	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACT75_01050	COG1122	ATPase activity
ACT75_01055	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACT75_01060	COG0310	cobalt ion transport
ACT75_01065	COG0310	cobalt ion transport
ACT75_01070	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
ACT75_01075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACT75_01080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT75_01085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACT75_01090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT75_01100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACT75_01115	COG2271	Major facilitator Superfamily
ACT75_01125	COG3718	enzyme involved in inositol metabolism
ACT75_01145	COG3501	Rhs element vgr protein
ACT75_01150	COG1609	Transcriptional regulator
ACT75_01155	COG2949	membrane
ACT75_01160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACT75_01180	COG0583	DNA-binding transcription factor activity
ACT75_01190	COG0009	L-threonylcarbamoyladenylate synthase
ACT75_01195	COG0287	Prephenate dehydrogenase
ACT75_01195	COG1605	Chorismate mutase
ACT75_01200	COG0616	signal peptide processing
ACT75_01205	COG0778	Nitroreductase
ACT75_01210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACT75_01215	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACT75_01220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACT75_01230	COG2909	trisaccharide binding
ACT75_01235	COG0058	SHG alpha-glucan phosphorylase activity
ACT75_01240	COG1640	4-alpha-glucanotransferase
ACT75_01245	COG1286	toxin biosynthetic process
ACT75_01250	COG3092	negative regulation of chromosome organization
ACT75_01255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACT75_01260	COG0280	phosphate acetyltransferase
ACT75_01260	COG0857	belongs to the CobB CobQ family
ACT75_01270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACT75_01275	COG0617	tRNA 3'-terminal CCA addition
ACT75_01280	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACT75_01285	COG2333	competence protein COMEC
ACT75_01285	COG0658	competence protein
ACT75_01290	COG1132	(ABC) transporter
ACT75_01295	COG1663	tetraacyldisaccharide 4'-kinase activity
ACT75_01300	COG2835	tetraacyldisaccharide 4'-kinase activity
ACT75_01310	COG0322	excinuclease ABC activity
ACT75_01320	COG0395	ABC-type sugar transport system, permease component
ACT75_01325	COG1175	transmembrane transport
ACT75_01340	COG3177	Filamentation induced by cAMP protein fic
ACT75_01350	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
ACT75_01355	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ACT75_01365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACT75_01380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACT75_01395	COG0195	Participates in both transcription termination and antitermination
ACT75_01470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACT75_01475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACT75_01485	COG0024	Methionine aminopeptidase
ACT75_01490	COG0316	Belongs to the HesB IscA family
ACT75_01500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACT75_01505	COG0672	)-iron permease
ACT75_01520	COG0577	efflux transmembrane transporter activity
ACT75_01520	COG1136	(ABC) transporter
ACT75_01530	COG1136	(ABC) transporter
ACT75_01530	COG0577	efflux transmembrane transporter activity
ACT75_01535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT75_01545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACT75_01555	COG1643	Atp-dependent helicase
ACT75_01560	COG2363	Small membrane protein
ACT75_01580	COG0247	lactate metabolic process
ACT75_01580	COG0277	FAD linked oxidase domain protein
ACT75_01595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ACT75_01600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ACT75_01605	COG0363	glucosamine-6-phosphate deaminase activity
ACT75_01610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACT75_01615	COG1737	Transcriptional regulator
ACT75_01625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
ACT75_01630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACT75_01635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACT75_01635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACT75_01640	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
ACT75_01645	COG1263	PTS System
ACT75_01645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT75_01645	COG2190	(PTS) system
ACT75_01655	COG3501	Rhs element vgr protein
ACT75_01670	COG3179	chitinase
ACT75_01735	COG1846	Transcriptional regulator
ACT75_01735	COG1940	carbohydrate kinase activity
ACT75_01745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACT75_01750	COG2226	methyltransferase
ACT75_01760	COG3422	double-strand break repair
ACT75_01770	COG1944	ATP diphosphatase activity
ACT75_01775	COG3105	Protein conserved in bacteria
ACT75_01780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACT75_01800	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
ACT75_01805	COG3683	transport system, periplasmic component
ACT75_01810	COG0488	(ABC) transporter
ACT75_01820	COG0187	DNA topoisomerase II activity
ACT75_01825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ACT75_01830	COG0625	glutathione transferase activity
ACT75_01835	COG2885	chlorophyll binding
ACT75_01835	COG3047	cAMP biosynthetic process
ACT75_01840	COG0616	signal peptide processing
ACT75_01850	COG1252	NADH dehydrogenase
ACT75_01860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ACT75_01870	COG0792	nuclease activity
ACT75_01875	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACT75_01880	COG2823	Periplasmic or secreted lipoprotein
ACT75_01885	COG0288	reversible hydration of carbon dioxide
ACT75_01890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACT75_01890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACT75_01895	COG0785	Cytochrome C biogenesis protein
ACT75_01900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT75_01915	COG2801	Transposase and inactivated derivatives
ACT75_01925	COG3069	C4-dicarboxylate transmembrane transporter activity
ACT75_01930	COG3077	Addiction module antitoxin, RelB DinJ family
ACT75_01935	COG3041	Addiction module toxin RelE StbE family
ACT75_01950	COG2351	hydroxyisourate hydrolase activity
ACT75_01955	COG0825	malonyl-CoA metabolic process
ACT75_01970	COG2252	PERMEase
ACT75_01975	COG3152	Membrane
ACT75_01980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACT75_01985	COG0375	protein maturation
ACT75_01990	COG2814	Major facilitator Superfamily
ACT75_01995	COG0563	adenylate kinase activity
ACT75_02000	COG2963	transposase activity
ACT75_02005	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ACT75_02010	COG3025	triphosphatase activity
ACT75_02015	COG1392	Phosphate transport regulator
ACT75_02020	COG0306	phosphate transporter
ACT75_02025	COG4991	sh3 domain protein
ACT75_02030	COG0617	tRNA 3'-terminal CCA addition
ACT75_02035	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACT75_02040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACT75_02055	COG1620	l-lactate permease
ACT75_02090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACT75_02100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACT75_02120	COG2026	Addiction module toxin, RelE StbE family
ACT75_02180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACT75_02190	COG1862	Preprotein translocase
ACT75_02195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACT75_02200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACT75_02210	COG1454	alcohol dehydrogenase
ACT75_02210	COG1012	belongs to the aldehyde dehydrogenase family
ACT75_02215	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT75_02220	COG1129	ABC transporter
ACT75_02225	COG1879	ABC-type sugar transport system periplasmic component
ACT75_02235	COG0673	inositol 2-dehydrogenase activity
ACT75_02275	COG0720	synthase
ACT75_02280	COG0602	queuosine metabolic process
ACT75_02285	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACT75_02290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACT75_02300	COG0783	Belongs to the Dps family
ACT75_02310	COG2814	Major facilitator Superfamily
ACT75_02320	COG3550	peptidyl-serine autophosphorylation
ACT75_02340	COG2927	DNA polymerase III (CHI subunit)
ACT75_02345	COG0114	fumarate hydratase activity
ACT75_02350	COG2268	Band 7 protein
ACT75_02360	COG0778	Nitroreductase
ACT75_02365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACT75_02375	COG0814	amino acid
ACT75_02410	COG0235	Class ii aldolase
ACT75_02415	COG3623	hexulose-6-phosphate isomerase
ACT75_02440	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ACT75_02465	COG3501	Rhs element vgr protein
ACT75_02470	COG4953	penicillin-binding protein 1C
ACT75_02475	COG2855	membrane
ACT75_02490	COG0157	Belongs to the NadC ModD family
ACT75_02495	COG3842	ATPase activity
ACT75_02500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACT75_02505	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACT75_02515	COG3676	manually curated
ACT75_02520	COG5339	Protein conserved in bacteria
ACT75_02525	COG0443	Heat shock 70 kDa protein
ACT75_02530	COG0484	heat shock protein binding
ACT75_02535	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACT75_02550	COG0626	cystathionine gamma-synthase activity
ACT75_02555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACT75_02575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACT75_02580	COG2999	glutathione oxidoreductase activity
ACT75_02585	COG1530	ribonuclease E activity
ACT75_02590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACT75_02640	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT75_02645	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT75_02670	COG2860	membrane
ACT75_02685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACT75_02695	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACT75_02700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACT75_02705	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
ACT75_02710	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ACT75_02735	COG2914	Belongs to the UPF0125 (RnfH) family
ACT75_02740	COG2850	peptidyl-arginine hydroxylation
ACT75_02745	COG1570	exodeoxyribonuclease VII activity
ACT75_02755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_02760	COG1137	ATPase activity
ACT75_02765	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACT75_02770	COG3117	lipopolysaccharide transmembrane transporter activity
ACT75_02775	COG1127	ABC transporter
ACT75_02780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACT75_02785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACT75_02790	COG2854	intermembrane phospholipid transfer
ACT75_02795	COG3113	response to antibiotic
ACT75_02800	COG5007	Belongs to the BolA IbaG family
ACT75_02810	COG3691	Protein conserved in bacteria
ACT75_02820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACT75_02830	COG0861	Integral membrane protein TerC family
ACT75_02845	COG3266	domain, Protein
ACT75_02845	COG3468	outer membrane autotransporter barrel domain protein
ACT75_02850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACT75_02855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACT75_02870	COG1125	glycine betaine transport
ACT75_02870	COG0517	IMP dehydrogenase activity
ACT75_02875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACT75_02885	COG0460	homoserine dehydrogenase
ACT75_02885	COG0527	aspartate kinase activity
ACT75_02900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACT75_02905	COG2091	lysine biosynthetic process via aminoadipic acid
ACT75_02910	COG0330	HflC and HflK could
ACT75_02915	COG0330	HflC and HflK could
ACT75_02920	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACT75_02925	COG4974	Belongs to the 'phage' integrase family
ACT75_02930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ACT75_02945	COG3266	domain, Protein
ACT75_02945	COG3061	Opacity-associated protein A
ACT75_02950	COG1509	lysine 2,3-aminomutase activity
ACT75_02960	COG3033	Beta-eliminating lyase
ACT75_02965	COG0814	amino acid
ACT75_02970	COG2964	Protein conserved in bacteria
ACT75_02975	COG5413	integral membrane protein
ACT75_02985	COG0204	Acyl-transferase
ACT75_02995	COG0697	spore germination
ACT75_03000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ACT75_03005	COG1882	Formate acetyltransferase
ACT75_03010	COG2116	formate transmembrane transporter activity
ACT75_03015	COG0537	adenosine 5'-monophosphoramidase activity
ACT75_03055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACT75_03070	COG0681	Belongs to the peptidase S26 family
ACT75_03100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACT75_03105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACT75_03110	COG0592	DNA-directed DNA polymerase activity
ACT75_03120	COG2226	methyltransferase
ACT75_03130	COG2081	HI0933 family
ACT75_03135	COG3088	subunit of a heme lyase
ACT75_03135	COG4235	cytochrome complex assembly
ACT75_03140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACT75_03145	COG1138	Cytochrome C-type biogenesis protein
ACT75_03150	COG3301	Polysulphide reductase, NrfD
ACT75_03155	COG0437	4 iron, 4 sulfur cluster binding
ACT75_03160	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
ACT75_03195	COG1138	Cytochrome C-type biogenesis protein
ACT75_03205	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT75_03210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT75_03215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACT75_03220	COG4133	protoheme IX ABC transporter activity
ACT75_03225	COG2814	Major facilitator Superfamily
ACT75_03275	COG2267	carboxylic ester hydrolase activity
ACT75_03280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ACT75_03290	COG0436	Aminotransferase
ACT75_03305	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACT75_03310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACT75_03315	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACT75_03325	COG1652	LysM domain
ACT75_03330	COG2321	neutral zinc metallopeptidase
ACT75_03345	COG0280	phosphate acetyltransferase
ACT75_03345	COG0281	malic enzyme
ACT75_03390	COG3091	SprT-like family
ACT75_03395	COG0814	amino acid
ACT75_03400	COG1760	l-serine dehydratase
ACT75_03405	COG0252	asparaginase activity
ACT75_03415	COG3063	Type IV pilus biogenesis stability protein PilW
ACT75_03420	COG1426	Protein conserved in bacteria
ACT75_03435	COG2976	Protein conserved in bacteria
ACT75_03445	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACT75_03450	COG2233	PERMEase
ACT75_03455	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACT75_03460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACT75_03465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACT75_03475	COG0659	secondary active sulfate transmembrane transporter activity
ACT75_03495	COG2186	Transcriptional regulator
ACT75_03510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACT75_03520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT75_03525	COG1028	Short-chain dehydrogenase reductase Sdr
ACT75_03535	COG0800	Aldolase
ACT75_03545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACT75_03550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACT75_03555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACT75_03565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACT75_03570	COG1555	photosystem II stabilization
ACT75_03580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACT75_03600	COG0196	riboflavin kinase activity
ACT75_03605	COG0728	peptidoglycan biosynthetic process
ACT75_03620	COG0560	Phosphoserine phosphatase
ACT75_03630	COG0193	aminoacyl-tRNA hydrolase activity
ACT75_03635	COG0012	GTP binding
ACT75_03640	COG1573	uracil-dna glycosylase
ACT75_03645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACT75_03655	COG3115	cell septum assembly
ACT75_03675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACT75_03680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACT75_03690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACT75_03700	COG0582	viral genome integration into host DNA
ACT75_03715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACT75_03720	COG0255	Belongs to the universal ribosomal protein uL29 family
ACT75_03725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACT75_03730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACT75_03735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACT75_03740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACT75_03745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACT75_03750	COG0089	rRNA binding
ACT75_03760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACT75_03765	COG0051	transcription antitermination factor activity, RNA binding
ACT75_03770	COG0583	DNA-binding transcription factor activity
ACT75_03775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACT75_03780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACT75_03785	COG2031	fatty acid transporter
ACT75_03790	COG0183	Belongs to the thiolase family
ACT75_03800	COG1288	antiporter activity
ACT75_03805	COG0549	Belongs to the carbamate kinase family
ACT75_03810	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACT75_03815	COG0038	chloride channel
ACT75_03820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACT75_03830	COG1522	sequence-specific DNA binding
ACT75_03835	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ACT75_03845	COG1393	Belongs to the ArsC family
ACT75_03855	COG3036	rescue of stalled ribosome
ACT75_03860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACT75_03865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACT75_03885	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ACT75_03895	COG0569	domain protein
ACT75_03900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACT75_03900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACT75_03940	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
ACT75_03945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACT75_03960	COG2960	long-chain fatty acid transporting porin activity
ACT75_03965	COG3172	ATPase kinase involved in NAD metabolism
ACT75_03970	COG2129	metallophosphoesterase
ACT75_03975	COG0814	amino acid
ACT75_03990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACT75_04005	COG0201	protein transport
ACT75_04015	COG1841	ribosomal large subunit assembly
ACT75_04025	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACT75_04035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACT75_04045	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACT75_04055	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACT75_04070	COG0805	protein transport
ACT75_04075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACT75_04080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACT75_04105	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACT75_04110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACT75_04115	COG1011	Hydrolase
ACT75_04120	COG0494	nUDIX hydrolase
ACT75_04125	COG1917	Cupin 2, conserved barrel domain protein
ACT75_04125	COG4977	sequence-specific DNA binding
ACT75_04130	COG3059	membrane
ACT75_04135	COG1297	OPT oligopeptide transporter protein
ACT75_04145	COG1218	3'(2'),5'-bisphosphate nucleotidase
ACT75_04150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ACT75_04155	COG0363	glucosamine-6-phosphate deaminase activity
ACT75_04175	COG0762	integral membrane protein
ACT75_04185	COG0778	Nitroreductase
ACT75_04225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACT75_04240	COG0006	proline dipeptidase activity
ACT75_04265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACT75_04270	COG1792	Involved in formation and maintenance of cell shape
ACT75_04275	COG1077	Cell shape determining protein MreB Mrl
ACT75_04280	COG0557	exoribonuclease II activity
ACT75_04290	COG2271	Major facilitator Superfamily
ACT75_04295	COG0584	glycerophosphoryl diester phosphodiesterase
ACT75_04300	COG0758	DNA mediated transformation
ACT75_04335	COG1132	(ABC) transporter
ACT75_04340	COG1917	Cupin 2, conserved barrel domain protein
ACT75_04340	COG4977	sequence-specific DNA binding
ACT75_04345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACT75_04350	COG0859	PFAM glycosyl transferase family 9
ACT75_04365	COG1519	Transferase
ACT75_04370	COG0463	Glycosyl transferase, family 2
ACT75_04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACT75_04390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACT75_04395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACT75_04400	COG3719	Belongs to the RNase T2 family
ACT75_04410	COG0191	fructose-bisphosphate aldolase activity
ACT75_04415	COG3307	-O-antigen
ACT75_04420	COG2267	carboxylic ester hydrolase activity
ACT75_04425	COG0561	phosphatase activity
ACT75_04430	COG0028	Belongs to the TPP enzyme family
ACT75_04435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACT75_04460	COG1072	(Pantothenic acid kinase))
ACT75_04465	COG0187	DNA topoisomerase II activity
ACT75_04470	COG0514	ATP-dependent DNA helicase (RecQ)
ACT75_04480	COG0019	diaminopimelate decarboxylase activity
ACT75_04485	COG3477	response to acidic pH
ACT75_04490	COG2818	Glycosylase
ACT75_04495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACT75_04505	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACT75_04510	COG0300	oxidoreductase activity
ACT75_04515	COG1763	Mo-molybdopterin cofactor biosynthetic process
ACT75_04520	COG3086	response to oxidative stress
ACT75_04525	COG3026	antisigma factor binding
ACT75_04530	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
ACT75_04535	COG1595	DNA-templated transcription, initiation
ACT75_04550	COG0442	prolyl-tRNA aminoacylation
ACT75_04555	COG1921	L-seryl-tRNASec selenium transferase activity
ACT75_04560	COG3276	selenocysteine insertion sequence binding
ACT75_04645	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACT75_04650	COG4589	Belongs to the CDS family
ACT75_04660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACT75_04665	COG0490	domain, Protein
ACT75_04665	COG0471	metal ion transport
ACT75_04685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACT75_04695	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
ACT75_04710	COG0575	Belongs to the CDS family
ACT75_04725	COG0233	cytoplasmic translational termination
ACT75_04740	COG4178	(ABC) transporter
ACT75_04750	COG1349	DNA-binding transcription factor activity
ACT75_04755	COG0705	Rhomboid family
ACT75_04780	COG0551	DNA topoisomerase type I activity
ACT75_04795	COG2962	Rard protein
ACT75_04800	COG0583	DNA-binding transcription factor activity
ACT75_04810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACT75_04825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACT75_04830	COG1879	ABC-type sugar transport system periplasmic component
ACT75_04835	COG1129	ABC transporter
ACT75_04840	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT75_04850	COG2183	response to ionizing radiation
ACT75_04865	COG0583	DNA-binding transcription factor activity
ACT75_04870	COG0471	metal ion transport
ACT75_04880	COG2183	response to ionizing radiation
ACT75_04885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACT75_04895	COG1595	DNA-templated transcription, initiation
ACT75_04905	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACT75_04910	COG3071	HemY protein
ACT75_04915	COG2959	enzyme of heme biosynthesis
ACT75_04925	COG0181	hydroxymethylbilane synthase activity
ACT75_04935	COG2197	response regulator
ACT75_04940	COG0729	surface antigen
ACT75_04945	COG2911	Protein conserved in bacteria
ACT75_04950	COG0248	Ppx GppA phosphatase
ACT75_04970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACT75_04975	COG3068	Protein conserved in bacteria
ACT75_04985	COG1349	DNA-binding transcription factor activity
ACT75_04990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACT75_05010	COG2272	Belongs to the type-B carboxylesterase lipase family
ACT75_05015	COG0667	Aldo Keto reductase
ACT75_05020	COG0656	L-ascorbic acid biosynthetic process
ACT75_05035	COG0433	COG0433 Predicted ATPase
ACT75_05040	COG2258	MOSC domain
ACT75_05045	COG3012	SEC-C Motif Domain Protein
ACT75_05055	COG1490	D-aminoacyl-tRNA deacylase activity
ACT75_05060	COG0786	glutamate:sodium symporter activity
ACT75_05065	COG2205	protein histidine kinase activity
ACT75_05070	COG0745	RESPONSE REGULATOR receiver
ACT75_05075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACT75_05085	COG3082	Protein of unknown function (DUF1414)
ACT75_05090	COG3083	sulfuric ester hydrolase activity
ACT75_05095	COG0402	S-adenosylhomocysteine deaminase activity
ACT75_05100	COG3956	TIGRFAM MazG family protein
ACT75_05115	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACT75_05125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACT75_05130	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ACT75_05135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACT75_05150	COG0148	phosphopyruvate hydratase activity
ACT75_05160	COG2991	Protein conserved in bacteria
ACT75_05165	COG1477	protein flavinylation
ACT75_05170	COG2871	sodium ion transport
ACT75_05175	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT75_05180	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT75_05185	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
ACT75_05200	COG0271	Belongs to the BolA IbaG family
ACT75_05205	COG3056	Lipoprotein
ACT75_05225	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACT75_05230	COG1194	a g-specific adenine glycosylase
ACT75_05240	COG3171	Protein conserved in bacteria
ACT75_05245	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT75_05250	COG1178	ABC-type Fe3 transport system permease component
ACT75_05255	COG3842	ATPase activity
ACT75_05270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACT75_05280	COG1561	YicC-like family, N-terminal region
ACT75_05285	COG0354	folic acid binding
ACT75_05300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACT75_05305	COG1381	Involved in DNA repair and RecF pathway recombination
ACT75_05310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACT75_05315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACT75_05320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACT75_05330	COG0500	methyltransferase
ACT75_05335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACT75_05340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT75_05345	COG1309	transcriptional regulator
ACT75_05350	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT75_05355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACT75_05370	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT75_05380	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT75_05400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACT75_05415	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACT75_05425	COG1309	transcriptional regulator
ACT75_05440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACT75_05445	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACT75_05450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ACT75_05455	COG4972	Pilus assembly protein
ACT75_05475	COG4796	Type ii and iii secretion system protein
ACT75_05490	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ACT75_05520	COG0653	protein targeting
ACT75_05535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACT75_05550	COG0789	Transcriptional regulator
ACT75_05555	COG4701	Protein of unknown function (DUF721)
ACT75_05570	COG0494	nUDIX hydrolase
ACT75_05575	COG1466	dna polymerase III delta subunit
ACT75_05580	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
ACT75_05595	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACT75_05600	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
ACT75_05605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACT75_05610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACT75_05615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACT75_05635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACT75_05640	COG4221	oxidoreductase activity
ACT75_05645	COG0789	Transcriptional regulator
ACT75_05650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACT75_05655	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACT75_05660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACT75_05665	COG4137	Cytochrome C assembly protein
ACT75_05670	COG4536	flavin adenine dinucleotide binding
ACT75_05675	COG0811	peptide transport
ACT75_05680	COG0848	biopolymer transport protein
ACT75_05690	COG4783	chaperone-mediated protein folding
ACT75_05700	COG0814	amino acid
ACT75_05725	COG0747	negative chemotaxis
ACT75_05730	COG2853	Lipoprotein
ACT75_05740	COG3501	Rhs element vgr protein
ACT75_05770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ACT75_05775	COG3610	response to peptide
ACT75_05780	COG2966	Psort location CytoplasmicMembrane, score
ACT75_05795	COG0545	Peptidyl-prolyl cis-trans isomerase
ACT75_05800	COG0688	phosphatidylethanolamine metabolic process
ACT75_05805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACT75_05815	COG2830	Protein of unknown function (DUF452)
ACT75_05820	COG0500	methyltransferase
ACT75_05830	COG1399	metal-binding, possibly nucleic acid-binding protein
ACT75_05835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACT75_05840	COG0416	fatty acid biosynthetic process
ACT75_05850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ACT75_05855	COG1028	Short-chain dehydrogenase reductase Sdr
ACT75_05865	COG2814	Major facilitator Superfamily
ACT75_05870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACT75_05875	COG0513	Belongs to the DEAD box helicase family
ACT75_05880	COG0799	negative regulation of ribosome biogenesis
ACT75_05890	COG0768	penicillin binding
ACT75_05895	COG0772	Belongs to the SEDS family
ACT75_05900	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT75_05900	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACT75_05905	COG1686	Belongs to the peptidase S11 family
ACT75_05935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACT75_05940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACT75_05945	COG0765	amino acid transport
ACT75_05950	COG1126	abc transporter atp-binding protein
ACT75_05955	COG2168	tRNA wobble position uridine thiolation
ACT75_05965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
ACT75_05970	COG2964	Protein conserved in bacteria
ACT75_05975	COG0545	Peptidyl-prolyl cis-trans isomerase
ACT75_05985	COG0678	peroxiredoxin activity
ACT75_05985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACT75_05990	COG0583	DNA-binding transcription factor activity
ACT75_05995	COG1309	transcriptional regulator
ACT75_06000	COG1132	(ABC) transporter
ACT75_06005	COG4988	ABC transporter
ACT75_06010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACT75_06015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ACT75_06020	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACT75_06030	COG1045	serine acetyltransferase
ACT75_06040	COG1494	fructose-1,6-bisphosphatase
ACT75_06050	COG0716	FMN binding
ACT75_06060	COG0702	epimerase
ACT75_06065	COG1733	regulation of RNA biosynthetic process
ACT75_06075	COG3312	ion transport
ACT75_06095	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACT75_06105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACT75_06120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACT75_06125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ACT75_06135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACT75_06145	COG1349	DNA-binding transcription factor activity
ACT75_06260	COG0459	protein refolding
ACT75_06265	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACT75_06275	COG1027	Aspartate ammonia-lyase
ACT75_06280	COG0859	PFAM glycosyl transferase family 9
ACT75_06285	COG3716	PTS system mannose fructose sorbose family IID component
ACT75_06290	COG3715	PTS system
ACT75_06295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT75_06295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_06300	COG2814	Major facilitator Superfamily
ACT75_06305	COG0662	Cupin 2, conserved barrel domain protein
ACT75_06305	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ACT75_06325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACT75_06335	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
ACT75_06345	COG0297	glycogen (starch) synthase activity
ACT75_06355	COG2207	Transcriptional regulator
ACT75_06355	COG1609	Transcriptional regulator
ACT75_06360	COG1757	Na H antiporter
ACT75_06365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ACT75_06370	COG4214	carbohydrate transport
ACT75_06375	COG1129	ABC transporter
ACT75_06380	COG4213	ABC transporter substrate-binding protein
ACT75_06385	COG2115	Belongs to the xylose isomerase family
ACT75_06405	COG3070	regulator of competence-specific genes
ACT75_06410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACT75_06420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACT75_06425	COG3850	Histidine kinase
ACT75_06430	COG3062	negative regulation of establishment of protein localization
ACT75_06435	COG0243	molybdopterin cofactor binding
ACT75_06440	COG0437	4 iron, 4 sulfur cluster binding
ACT75_06445	COG0348	domain, Protein
ACT75_06450	COG3043	anaerobic respiration
ACT75_06455	COG3005	denitrification pathway
ACT75_06460	COG0754	glutathionylspermidine amidase activity
ACT75_06465	COG0859	PFAM glycosyl transferase family 9
ACT75_06475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACT75_06485	COG0737	Belongs to the 5'-nucleotidase family
ACT75_06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT75_06515	COG1028	Short-chain dehydrogenase reductase Sdr
ACT75_06525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT75_06580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACT75_06605	COG1011	Hydrolase
ACT75_06615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACT75_06620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACT75_06640	COG1555	photosystem II stabilization
ACT75_06640	COG1596	polysaccharide export
ACT75_06645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACT75_06650	COG0561	phosphatase activity
ACT75_06655	COG1040	competence protein
ACT75_06670	COG1114	Component of the transport system for branched-chain amino acids
ACT75_06690	COG4804	nuclease activity
ACT75_06700	COG4545	Glutaredoxin-related protein
ACT75_06715	COG3381	protein complex oligomerization
ACT75_06720	COG3302	dmso reductase anchor subunit
ACT75_06725	COG0437	4 iron, 4 sulfur cluster binding
ACT75_06730	COG0243	molybdopterin cofactor binding
ACT75_06740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACT75_06740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACT75_06750	COG5645	(Lipo)protein
ACT75_06755	COG0210	DNA helicase
ACT75_06780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACT75_06785	COG0110	maltose O-acetyltransferase activity
ACT75_06790	COG1238	metal cluster binding
ACT75_06875	COG3561	AntA/AntB antirepressor
ACT75_06920	COG0582	viral genome integration into host DNA
ACT75_06935	COG2095	MarC family integral membrane protein
ACT75_06945	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACT75_06950	COG2137	regulation of response to DNA damage stimulus
ACT75_06955	COG0251	oxidation-reduction process
ACT75_06965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACT75_07020	COG0513	Belongs to the DEAD box helicase family
ACT75_07030	COG3201	nicotinamide mononucleotide transporter
ACT75_07045	COG3078	GTPase activator activity
ACT75_07055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACT75_07060	COG0456	acetyltransferase
ACT75_07070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ACT75_07095	COG0511	ligase activity, forming carbon-carbon bonds
ACT75_07100	COG0439	Biotin carboxylase
ACT75_07115	COG3924	membrane
ACT75_07120	COG4145	pantothenate transmembrane transporter activity
ACT75_07125	COG2184	nucleotidyltransferase activity
ACT75_07150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACT75_07155	COG1115	amino acid carrier protein
ACT75_07165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACT75_07170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACT75_07170	COG0237	dephospho-CoA kinase activity
ACT75_07175	COG2801	Transposase and inactivated derivatives
ACT75_07200	COG2918	glutathione biosynthetic process
ACT75_07200	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACT75_07205	COG2194	sulfuric ester hydrolase activity
ACT75_07210	COG0740	serine-type endopeptidase activity
ACT75_07230	COG3739	integral membrane protein
ACT75_07235	COG2217	Heavy metal translocating P-type atpase
ACT75_07240	COG2608	mercury ion transmembrane transporter activity
ACT75_07260	COG2932	Transcriptional regulator
ACT75_07280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACT75_07300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACT75_07345	COG1459	type II secretion system
ACT75_07350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ACT75_07355	COG4969	Belongs to the N-Me-Phe pilin family
ACT75_07360	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACT75_07365	COG2731	YhcH YjgK YiaL family protein
ACT75_07375	COG4785	May be involved in cell division
ACT75_07380	COG0513	Belongs to the DEAD box helicase family
ACT75_07390	COG3835	regulator
ACT75_07395	COG2610	gluconate transmembrane transporter activity
ACT75_07400	COG1929	Belongs to the glycerate kinase type-1 family
ACT75_07405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ACT75_07410	COG0312	modulator of DNA gyrase
ACT75_07415	COG3028	Belongs to the UPF0307 family
ACT75_07420	COG0471	metal ion transport
ACT75_07430	COG1575	Belongs to the MenA family. Type 1 subfamily
ACT75_07435	COG1720	tRNA m6t6A37 methyltransferase activity
ACT75_07465	COG2177	Part of the ABC transporter FtsEX involved in
ACT75_07470	COG2884	Cell division ATP-binding protein ftsE
ACT75_07475	COG0552	protein localization to endoplasmic reticulum
ACT75_07480	COG0742	ribosomal rna small subunit methyltransferase
ACT75_07485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_07485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ACT75_07490	COG3715	PTS system
ACT75_07495	COG3716	PTS system mannose fructose sorbose family IID component
ACT75_07500	COG0561	phosphatase activity
ACT75_07505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACT75_07520	COG0726	polysaccharide deacetylase
ACT75_07520	COG1649	PFAM Uncharacterised BCR, COG1649
ACT75_07525	COG1215	transferase activity, transferring glycosyl groups
ACT75_07535	COG2271	Major facilitator Superfamily
ACT75_07560	COG2801	Transposase and inactivated derivatives
ACT75_07580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACT75_07590	COG1758	RNA polymerase activity
ACT75_07595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACT75_07605	COG3161	chorismate lyase activity
ACT75_07645	COG1285	pathogenesis
ACT75_07655	COG0733	neurotransmitter:sodium symporter activity
ACT75_07660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACT75_07675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACT75_07705	COG1238	metal cluster binding
ACT75_07715	COG4942	peptidase
ACT75_07715	COG1388	LysM domain
ACT75_07735	COG0105	UTP biosynthetic process
ACT75_07755	COG4535	Mg2 and Co2 transporter CorC
ACT75_07760	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
ACT75_07770	COG2301	Belongs to the HpcH HpaI aldolase family
ACT75_07775	COG3051	citrate lyase alpha subunit
ACT75_07780	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
ACT75_07780	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ACT75_07785	COG0471	metal ion transport
ACT75_07800	COG2017	converts alpha-aldose to the beta-anomer
ACT75_07810	COG1085	galactose-1-phosphate uridylyltransferase
ACT75_07815	COG1609	Transcriptional regulator
ACT75_07820	COG1879	ABC-type sugar transport system periplasmic component
ACT75_07830	COG4211	Belongs to the binding-protein-dependent transport system permease family
ACT75_07835	COG5002	protein histidine kinase activity
ACT75_07835	COG0784	Response regulator, receiver
ACT75_07835	COG2198	Histidine kinase
ACT75_07840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACT75_07845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACT75_07845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACT75_07855	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACT75_07865	COG0497	DNA recombination
ACT75_07880	COG2917	probably involved in intracellular septation
ACT75_07885	COG1607	acyl-coa hydrolase
ACT75_07890	COG2350	Protein conserved in bacteria
ACT75_07895	COG0741	lytic transglycosylase activity
ACT75_07905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACT75_07920	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACT75_07925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACT75_07930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACT75_07940	COG1408	metallophosphoesterase
ACT75_07945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ACT75_07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT75_07955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACT75_07960	COG1120	ATPase activity
ACT75_07970	COG1053	succinate dehydrogenase
ACT75_07975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACT75_07985	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
ACT75_08020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACT75_08025	COG0494	nUDIX hydrolase
ACT75_08030	COG1876	peptidase activity
ACT75_08040	COG1393	Belongs to the ArsC family
ACT75_08045	COG0326	Molecular chaperone. Has ATPase activity
ACT75_08050	COG0077	Prephenate dehydratase
ACT75_08050	COG1605	Chorismate mutase
ACT75_08060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACT75_08065	COG0849	cell division
ACT75_08070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACT75_08085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACT75_08105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACT75_08115	COG0768	penicillin binding
ACT75_08120	COG3116	cell division
ACT75_08135	COG1966	Carbon starvation protein
ACT75_08140	COG4160	amino acid transport
ACT75_08145	COG4215	(ABC) transporter
ACT75_08150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACT75_08155	COG1126	abc transporter atp-binding protein
ACT75_08165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACT75_08170	COG3293	Transposase
ACT75_08175	COG1444	tRNA N-acetyltransferase activity
ACT75_08185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACT75_08215	COG4964	Belongs to the GSP D family
ACT75_08315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACT75_08315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACT75_08315	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ACT75_08320	COG1105	Belongs to the carbohydrate kinase PfkB family
ACT75_08325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_08325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_08335	COG0746	molybdenum cofactor guanylyltransferase activity
ACT75_08340	COG3084	Protein conserved in bacteria
ACT75_08345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACT75_08350	COG3085	chromosome segregation
ACT75_08400	COG0561	phosphatase activity
ACT75_08410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACT75_08425	COG3622	Belongs to the hyi family
ACT75_08430	COG0235	Class ii aldolase
ACT75_08435	COG3395	kinase activity
ACT75_08440	COG2084	Dehydrogenase
ACT75_08445	COG1349	DNA-binding transcription factor activity
ACT75_08450	COG0347	Belongs to the P(II) protein family
ACT75_08455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACT75_08460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACT75_08465	COG0470	DNA polymerase III
ACT75_08470	COG0084	hydrolase, TatD family'
ACT75_08480	COG1253	flavin adenine dinucleotide binding
ACT75_08510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACT75_08515	COG4942	peptidase
ACT75_08520	COG2861	carbohydrate metabolic process
ACT75_08525	COG0606	chelatase, subunit chli
ACT75_08535	COG2990	Protein conserved in bacteria
ACT75_08540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACT75_08560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACT75_08615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACT75_08625	COG0084	hydrolase, TatD family'
ACT75_08630	COG0602	queuosine metabolic process
ACT75_08635	COG1328	CTP reductase activity
ACT75_08635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACT75_08645	COG1022	Amp-dependent synthetase and ligase
ACT75_08650	COG0587	DNA-directed DNA polymerase activity
ACT75_08670	COG0753	catalase activity
ACT75_08675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACT75_08680	COG0165	Argininosuccinate lyase
ACT75_08715	COG0582	viral genome integration into host DNA
ACT75_08820	COG3561	AntA/AntB antirepressor
ACT75_08830	COG0305	Participates in initiation and elongation during chromosome replication
ACT75_08850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACT75_08870	COG3617	BRO family, N-terminal domain
ACT75_08890	COG3179	chitinase
ACT75_08905	COG3728	DNA packaging
ACT75_08915	COG3567	Phage-associated protein, HI1409 family
ACT75_08920	COG2369	cell adhesion
ACT75_08930	COG3566	protein conserved in bacteria
ACT75_09040	COG1278	Cold shock
ACT75_09045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT75_09050	COG1879	ABC-type sugar transport system periplasmic component
ACT75_09055	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACT75_09065	COG1869	D-ribose catabolic process
ACT75_09075	COG0730	response to heat
ACT75_09085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACT75_09095	COG0590	tRNA wobble adenosine to inosine editing
ACT75_09135	COG0489	protein tyrosine kinase activity
ACT75_09140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACT75_09140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACT75_09145	COG2975	iron-sulfur cluster assembly
ACT75_09150	COG0633	Ferredoxin
ACT75_09155	COG0443	Heat shock 70 kDa protein
ACT75_09170	COG0822	iron-sulfur transferase activity
ACT75_09180	COG1959	2 iron, 2 sulfur cluster binding
ACT75_09185	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACT75_09250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACT75_09265	COG1530	ribonuclease E activity
ACT75_09275	COG2259	Doxx family
ACT75_09285	COG1611	Belongs to the LOG family
ACT75_09295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ACT75_09300	COG0745	RESPONSE REGULATOR receiver
ACT75_09305	COG4608	Belongs to the ABC transporter superfamily
ACT75_09310	COG0444	Belongs to the ABC transporter superfamily
ACT75_09315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACT75_09320	COG0601	transmembrane transport
ACT75_09325	COG0601	transmembrane transport
ACT75_09330	COG4166	transmembrane transport
ACT75_09340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACT75_09345	COG0697	spore germination
ACT75_09350	COG0697	spore germination
ACT75_09365	COG0142	geranyltranstransferase activity
ACT75_09370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACT75_09385	COG2056	Na+-H+ antiporter family
ACT75_09390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACT75_09395	COG0346	lactoylglutathione lyase activity
ACT75_09405	COG2271	Major facilitator Superfamily
ACT75_09420	COG1755	Isoprenylcysteine carboxyl methyltransferase
ACT75_09425	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACT75_09430	COG2801	Transposase and inactivated derivatives
ACT75_09445	COG0494	nUDIX hydrolase
ACT75_09450	COG0217	transcriptional regulatory protein
ACT75_09480	COG1271	oxidase subunit
ACT75_09485	COG1294	oxidase, subunit
ACT75_09495	COG0824	Thioesterase
ACT75_09500	COG0811	peptide transport
ACT75_09505	COG0848	biopolymer transport protein
ACT75_09510	COG3064	Membrane
ACT75_09540	COG2165	general secretion pathway protein
ACT75_09545	COG4795	General secretion pathway protein
ACT75_09560	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACT75_09565	COG0456	acetyltransferase
ACT75_09570	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
ACT75_09575	COG2813	Specifically methylates the guanine in position
ACT75_09590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACT75_09600	COG2994	toxin metabolic process
ACT75_09605	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
ACT75_09610	COG2274	protein secretion by the type I secretion system
ACT75_09615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT75_09625	COG0246	Mannitol dehydrogenase
ACT75_09630	COG3722	fumarate hydratase activity
ACT75_09635	COG0673	inositol 2-dehydrogenase activity
ACT75_09645	COG3962	Belongs to the TPP enzyme family
ACT75_09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACT75_09695	COG3959	Transketolase, thiamine diphosphate binding domain
ACT75_09700	COG3958	Transketolase
ACT75_09715	COG1289	transmembrane transporter activity
ACT75_09720	COG3304	Inner membrane component domain
ACT75_09725	COG1803	Methylglyoxal synthase
ACT75_09740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT75_09745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACT75_09750	COG1121	(ABC) transporter
ACT75_09760	COG2920	part of a sulfur-relay system
ACT75_09780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ACT75_09795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
ACT75_09840	COG0351	phosphomethylpyrimidine kinase
ACT75_09840	COG0351	phosphomethylpyrimidine kinase
ACT75_09845	COG4143	(ABC) transporter
ACT75_09850	COG1178	ABC-type Fe3 transport system permease component
ACT75_09855	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
ACT75_09865	COG1522	sequence-specific DNA binding
ACT75_09880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACT75_09885	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ACT75_09900	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ACT75_09905	COG1177	transmembrane transport
ACT75_09910	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACT75_09915	COG3842	ATPase activity
ACT75_09925	COG3008	intermembrane lipid transfer
ACT75_09930	COG2995	paraquat-inducible protein a
ACT75_09935	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
ACT75_09940	COG0793	Belongs to the peptidase S41A family
ACT75_09945	COG2989	Protein conserved in bacteria
ACT75_09950	COG3108	Peptidase M15
ACT75_09955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACT75_09960	COG0567	Dehydrogenase, E1 component
ACT75_09965	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACT75_09975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACT75_09995	COG3383	formate dehydrogenase (NAD+) activity
ACT75_10000	COG3383	formate dehydrogenase (NAD+) activity
ACT75_10010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ACT75_10020	COG3260	NADH ubiquinone oxidoreductase 20
ACT75_10025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACT75_10030	COG3261	NADH dehydrogenase
ACT75_10030	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
ACT75_10035	COG0651	ATP synthesis coupled electron transport
ACT75_10040	COG4237	Hydrogenase 4 membrane
ACT75_10045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACT75_10050	COG0650	Formate hydrogenlyase subunit 4
ACT75_10055	COG0651	ATP synthesis coupled electron transport
ACT75_10060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACT75_10065	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ACT75_10070	COG2864	formate dehydrogenase
ACT75_10075	COG0437	4 iron, 4 sulfur cluster binding
ACT75_10095	COG1609	Transcriptional regulator
ACT75_10100	COG3265	gluconokinase activity
ACT75_10105	COG2610	gluconate transmembrane transporter activity
ACT75_10110	COG0210	DNA helicase
ACT75_10115	COG1793	dna ligase
ACT75_10120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ACT75_10125	COG4115	mRNA cleavage
ACT75_10130	COG2161	toxin-antitoxin pair type II binding
ACT75_10135	COG5039	Polysaccharide pyruvyl transferase
ACT75_10145	COG3306	glycosyltransferase involved in LPS biosynthesis
ACT75_10155	COG1216	Glycosyl transferase, family 2
ACT75_10160	COG1216	Glycosyl transferase, family 2
ACT75_10165	COG2951	lytic endotransglycosylase activity
ACT75_10170	COG0708	Exodeoxyribonuclease III
ACT75_10175	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
ACT75_10180	COG1088	dTDP-glucose 4,6-dehydratase activity
ACT75_10190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACT75_10195	COG0671	phosphoesterase, PA-phosphatase related
ACT75_10200	COG1940	carbohydrate kinase activity
ACT75_10220	COG0515	serine threonine protein kinase
ACT75_10225	COG1946	Acyl-CoA thioesterase
ACT75_10230	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ACT75_10235	COG4988	ABC transporter
ACT75_10240	COG0492	ferredoxin-NADP+ reductase activity
ACT75_10245	COG3118	belongs to the thioredoxin family
ACT75_10255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACT75_10260	COG0303	'Molybdopterin
ACT75_10270	COG2027	D-alanyl-D-alanine carboxypeptidase
ACT75_10275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACT75_10280	COG1534	Rna-binding protein
ACT75_10285	COG3657	addiction module killer protein
ACT75_10290	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACT75_10295	COG0307	riboflavin synthase, alpha
ACT75_10305	COG4774	siderophore transport
ACT75_10310	COG4178	(ABC) transporter
ACT75_10315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACT75_10320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACT75_10330	COG3102	Protein conserved in bacteria
ACT75_10335	COG3133	Outer membrane lipoprotein
ACT75_10340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACT75_10345	COG2890	protein-(glutamine-N5) methyltransferase activity
ACT75_10355	COG0791	NLP P60 protein
ACT75_10365	COG3100	YcgL domain-containing protein
ACT75_10380	COG2062	phosphohistidine phosphatase, SixA
ACT75_10390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACT75_10395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACT75_10405	COG2932	Transcriptional regulator
ACT75_10415	COG0517	IMP dehydrogenase activity
ACT75_10415	COG0516	GMP reductase activity
ACT75_10420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ACT75_10420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ACT75_10450	COG4172	Belongs to the ABC transporter superfamily
ACT75_10455	COG4172	Belongs to the ABC transporter superfamily
ACT75_10460	COG4171	peptide transport system, permease
ACT75_10465	COG4168	peptide transport system, permease
ACT75_10470	COG4166	transmembrane transport
ACT75_10475	COG3106	COG3106 Predicted ATPase
ACT75_10485	COG3283	Transcriptional regulator of aromatic amino acids metabolism
ACT75_10490	COG1923	regulation of RNA biosynthetic process
ACT75_10505	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACT75_10505	COG1388	LysM domain
ACT75_10510	COG0802	atpase or kinase
ACT75_10525	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ACT75_10535	COG2194	sulfuric ester hydrolase activity
ACT75_10570	COG2337	Toxic component of a toxin-antitoxin (TA) module
ACT75_10590	COG3021	interspecies interaction between organisms
ACT75_10665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACT75_10670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACT75_10675	COG2190	(PTS) system
ACT75_10680	COG0339	signal peptide processing
ACT75_10685	COG2832	Protein of unknown function (DUF454)
ACT75_10720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACT75_10730	COG0512	Glutamine amidotransferase of anthranilate synthase
ACT75_10735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACT75_10770	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACT75_10780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACT75_10790	COG3684	Belongs to the aldolase LacD family
ACT75_10795	COG3775	system Galactitol-specific IIC component
ACT75_10800	COG1063	alcohol dehydrogenase
ACT75_10805	COG1349	DNA-binding transcription factor activity
ACT75_10815	COG0142	geranyltranstransferase activity
ACT75_10830	COG0285	dihydrofolate synthase activity
ACT75_10835	COG0406	alpha-ribazole phosphatase activity
ACT75_10840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACT75_10845	COG2431	L-lysine efflux transmembrane transporter activity
ACT75_10850	COG0564	pseudouridine synthase activity
ACT75_10860	COG2824	Alkylphosphonate utilization operon protein PhnA
ACT75_10870	COG1538	Outer membrane efflux protein
ACT75_10875	COG1136	(ABC) transporter
ACT75_10875	COG0577	efflux transmembrane transporter activity
ACT75_10880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACT75_10900	COG2983	Belongs to the UPF0260 family
ACT75_10930	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACT75_10940	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACT75_10945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACT75_10950	COG0305	Participates in initiation and elongation during chromosome replication
ACT75_10960	COG0166	Belongs to the GPI family
ACT75_10970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACT75_10980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACT75_10985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACT75_10990	COG1280	lysine exporter protein (LysE YggA)
ACT75_11000	COG0633	Ferredoxin
ACT75_11010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT75_11025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT75_11035	COG1840	ABC-type Fe3 transport system, periplasmic component
ACT75_11045	COG3842	ATPase activity
ACT75_11050	COG0366	Alpha amylase catalytic
ACT75_11055	COG3833	ABC-type maltose transport systems, permease component
ACT75_11065	COG2182	Extracellular solute-binding protein
ACT75_11070	COG3842	ATPase activity
ACT75_11075	COG4580	involved in the transport of maltose and maltodextrins
ACT75_11085	COG0676	glucose-6-phosphate 1-epimerase activity
ACT75_11090	COG1199	ATP-dependent helicase activity
ACT75_11095	COG1214	PFAM Peptidase M22, glycoprotease
ACT75_11100	COG3065	identical protein binding
ACT75_11105	COG0318	PFAM AMP-dependent synthetase and ligase
ACT75_11110	COG0318	PFAM AMP-dependent synthetase and ligase
ACT75_11115	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ACT75_11120	COG1858	cytochrome C peroxidase
ACT75_11145	COG0330	HflC and HflK could
ACT75_11155	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACT75_11160	COG3381	protein complex oligomerization
ACT75_11165	COG1560	Kdo2-lipid A biosynthetic process
ACT75_11170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACT75_11170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACT75_11175	COG2166	iron-sulfur cluster assembly
ACT75_11180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACT75_11185	COG1525	nuclease
ACT75_11200	COG4774	siderophore transport
ACT75_11220	COG1120	ATPase activity
ACT75_11235	COG3585	molybdate ion transport
ACT75_11245	COG1120	ATPase activity
ACT75_11280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACT75_11290	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ACT75_11295	COG0314	molybdopterin synthase activity
ACT75_11305	COG2969	positive regulation of protein catabolic process
ACT75_11315	COG1940	carbohydrate kinase activity
ACT75_11320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACT75_11325	COG1070	Carbohydrate kinase
ACT75_11330	COG2390	Transcriptional regulator
ACT75_11365	COG0469	pyruvate kinase activity
ACT75_11375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACT75_11385	COG0133	tryptophan synthase activity
ACT75_11390	COG4221	oxidoreductase activity
ACT75_11400	COG1629	transport
ACT75_11400	COG4771	TonB-dependent receptor
ACT75_11405	COG4771	TonB-dependent receptor
ACT75_11405	COG1629	transport
ACT75_11420	COG3630	sodium ion export across plasma membrane
ACT75_11430	COG0298	carbon dioxide binding
ACT75_11440	COG0135	phosphoribosylanthranilate isomerase activity
ACT75_11440	COG0134	indole-3-glycerol-phosphate synthase activity
ACT75_11445	COG3093	addiction module antidote protein HigA
ACT75_11455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACT75_11460	COG1942	4-Oxalocrotonate Tautomerase
ACT75_11465	COG0512	Glutamine amidotransferase of anthranilate synthase
ACT75_11470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ACT75_11475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACT75_11480	COG0517	IMP dehydrogenase activity
ACT75_11480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACT75_11490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACT75_11505	COG0791	NLP P60 protein
ACT75_11520	COG0842	Transport permease protein