locus-tag	class	description
KO461_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KO461_00010	COG0592	DNA-directed DNA polymerase activity
KO461_00020	COG2226	methyltransferase
KO461_00030	COG2081	HI0933 family
KO461_00035	COG3088	subunit of a heme lyase
KO461_00035	COG4235	cytochrome complex assembly
KO461_00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_00045	COG1138	Cytochrome C-type biogenesis protein
KO461_00050	COG3301	Polysulphide reductase, NrfD
KO461_00055	COG0437	4 iron, 4 sulfur cluster binding
KO461_00060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
KO461_00095	COG1138	Cytochrome C-type biogenesis protein
KO461_00105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_00110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_00115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO461_00120	COG4133	protoheme IX ABC transporter activity
KO461_00165	COG2801	Transposase and inactivated derivatives
KO461_00180	COG2267	carboxylic ester hydrolase activity
KO461_00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KO461_00195	COG0436	Aminotransferase
KO461_00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KO461_00220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KO461_00225	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KO461_00235	COG1652	LysM domain
KO461_00240	COG2321	neutral zinc metallopeptidase
KO461_00255	COG0281	malic enzyme
KO461_00255	COG0280	phosphate acetyltransferase
KO461_00295	COG2801	Transposase and inactivated derivatives
KO461_00300	COG3091	SprT-like family
KO461_00305	COG0814	amino acid
KO461_00310	COG1760	l-serine dehydratase
KO461_00315	COG0252	asparaginase activity
KO461_00325	COG3063	Type IV pilus biogenesis stability protein PilW
KO461_00330	COG1426	Protein conserved in bacteria
KO461_00345	COG2976	Protein conserved in bacteria
KO461_00355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KO461_00360	COG2233	PERMEase
KO461_00365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KO461_00370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO461_00375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KO461_00385	COG0659	secondary active sulfate transmembrane transporter activity
KO461_00405	COG2186	Transcriptional regulator
KO461_00420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KO461_00430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_00435	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_00445	COG0800	Aldolase
KO461_00450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO461_00455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KO461_00460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KO461_00465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO461_00475	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KO461_00480	COG1555	photosystem II stabilization
KO461_00490	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KO461_00510	COG0196	riboflavin kinase activity
KO461_00515	COG0728	peptidoglycan biosynthetic process
KO461_00530	COG0560	Phosphoserine phosphatase
KO461_00540	COG0193	aminoacyl-tRNA hydrolase activity
KO461_00545	COG0012	GTP binding
KO461_00555	COG1573	uracil-dna glycosylase
KO461_00560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KO461_00570	COG3115	cell septum assembly
KO461_00590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KO461_00595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KO461_00615	COG0582	viral genome integration into host DNA
KO461_00635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KO461_00640	COG0255	Belongs to the universal ribosomal protein uL29 family
KO461_00645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KO461_00650	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KO461_00655	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KO461_00660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KO461_00665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KO461_00670	COG0089	rRNA binding
KO461_00675	COG0088	Forms part of the polypeptide exit tunnel
KO461_00680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KO461_00685	COG0051	transcription antitermination factor activity, RNA binding
KO461_00695	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KO461_00700	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KO461_00705	COG2031	fatty acid transporter
KO461_00710	COG0183	Belongs to the thiolase family
KO461_00720	COG1288	antiporter activity
KO461_00725	COG0549	Belongs to the carbamate kinase family
KO461_00730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KO461_00735	COG0038	chloride channel
KO461_00740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KO461_00750	COG1522	sequence-specific DNA binding
KO461_00755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
KO461_00765	COG1393	Belongs to the ArsC family
KO461_00775	COG3036	rescue of stalled ribosome
KO461_00785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KO461_00805	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KO461_00815	COG0569	domain protein
KO461_00820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KO461_00820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KO461_00860	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
KO461_00865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KO461_00880	COG2960	long-chain fatty acid transporting porin activity
KO461_00885	COG3172	ATPase kinase involved in NAD metabolism
KO461_00890	COG2129	metallophosphoesterase
KO461_00895	COG0814	amino acid
KO461_00910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KO461_00930	COG0201	protein transport
KO461_00950	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KO461_00960	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KO461_00970	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KO461_00995	COG0805	protein transport
KO461_01000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO461_01005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO461_01030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KO461_01035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KO461_01040	COG1011	Hydrolase
KO461_01045	COG0494	nUDIX hydrolase
KO461_01050	COG1917	Cupin 2, conserved barrel domain protein
KO461_01050	COG4977	sequence-specific DNA binding
KO461_01055	COG3059	membrane
KO461_01060	COG1297	OPT oligopeptide transporter protein
KO461_01070	COG1218	3'(2'),5'-bisphosphate nucleotidase
KO461_01075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KO461_01080	COG0363	glucosamine-6-phosphate deaminase activity
KO461_01100	COG0762	integral membrane protein
KO461_01110	COG0778	Nitroreductase
KO461_01130	COG1496	oxidoreductase activity
KO461_01145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KO461_01165	COG0006	proline dipeptidase activity
KO461_01190	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KO461_01195	COG1792	Involved in formation and maintenance of cell shape
KO461_01200	COG1077	Cell shape determining protein MreB Mrl
KO461_01205	COG0557	exoribonuclease II activity
KO461_01215	COG2271	Major facilitator Superfamily
KO461_01220	COG0584	glycerophosphoryl diester phosphodiesterase
KO461_01225	COG0758	DNA mediated transformation
KO461_01260	COG1132	(ABC) transporter
KO461_01265	COG1917	Cupin 2, conserved barrel domain protein
KO461_01265	COG4977	sequence-specific DNA binding
KO461_01270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KO461_01275	COG0859	PFAM glycosyl transferase family 9
KO461_01290	COG1519	Transferase
KO461_01295	COG0463	Glycosyl transferase, family 2
KO461_01310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO461_01315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KO461_01320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KO461_01325	COG3719	Belongs to the RNase T2 family
KO461_01335	COG0191	fructose-bisphosphate aldolase activity
KO461_01340	COG3307	-O-antigen
KO461_01345	COG2267	carboxylic ester hydrolase activity
KO461_01350	COG0561	phosphatase activity
KO461_01360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KO461_01385	COG1072	(Pantothenic acid kinase))
KO461_01390	COG0187	DNA topoisomerase II activity
KO461_01395	COG0514	ATP-dependent DNA helicase (RecQ)
KO461_01405	COG0019	diaminopimelate decarboxylase activity
KO461_01410	COG3477	response to acidic pH
KO461_01415	COG2818	Glycosylase
KO461_01420	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
KO461_01430	COG2195	Cleaves the N-terminal amino acid of tripeptides
KO461_01435	COG2801	Transposase and inactivated derivatives
KO461_01450	COG0300	oxidoreductase activity
KO461_01455	COG1763	Mo-molybdopterin cofactor biosynthetic process
KO461_01460	COG3086	response to oxidative stress
KO461_01465	COG3026	antisigma factor binding
KO461_01470	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
KO461_01475	COG1595	DNA-templated transcription, initiation
KO461_01490	COG0442	prolyl-tRNA aminoacylation
KO461_01495	COG1921	L-seryl-tRNASec selenium transferase activity
KO461_01500	COG3276	selenocysteine insertion sequence binding
KO461_01565	COG0521	Mo-molybdopterin cofactor biosynthetic process
KO461_01570	COG4589	Belongs to the CDS family
KO461_01580	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KO461_01585	COG0471	metal ion transport
KO461_01585	COG0490	domain, Protein
KO461_01615	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
KO461_01630	COG0575	Belongs to the CDS family
KO461_01645	COG0233	cytoplasmic translational termination
KO461_01660	COG4178	(ABC) transporter
KO461_01670	COG1349	DNA-binding transcription factor activity
KO461_01675	COG0705	Rhomboid family
KO461_01700	COG0551	DNA topoisomerase type I activity
KO461_01715	COG2962	Rard protein
KO461_01720	COG0583	DNA-binding transcription factor activity
KO461_01730	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KO461_01745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KO461_01750	COG1879	ABC-type sugar transport system periplasmic component
KO461_01755	COG1129	ABC transporter
KO461_01760	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_01770	COG2183	response to ionizing radiation
KO461_01780	COG2801	Transposase and inactivated derivatives
KO461_01790	COG0583	DNA-binding transcription factor activity
KO461_01795	COG0471	metal ion transport
KO461_01810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KO461_01820	COG1595	DNA-templated transcription, initiation
KO461_01830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KO461_01835	COG3071	HemY protein
KO461_01840	COG2959	enzyme of heme biosynthesis
KO461_01850	COG0181	hydroxymethylbilane synthase activity
KO461_01860	COG2197	response regulator
KO461_01865	COG0729	surface antigen
KO461_01870	COG2911	Protein conserved in bacteria
KO461_01875	COG0248	Ppx GppA phosphatase
KO461_01895	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KO461_01900	COG3068	Protein conserved in bacteria
KO461_01910	COG1349	DNA-binding transcription factor activity
KO461_01915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KO461_01935	COG2272	Belongs to the type-B carboxylesterase lipase family
KO461_01945	COG0667	Aldo Keto reductase
KO461_01965	COG0433	COG0433 Predicted ATPase
KO461_01970	COG2258	MOSC domain
KO461_01975	COG3012	SEC-C Motif Domain Protein
KO461_01985	COG1490	D-aminoacyl-tRNA deacylase activity
KO461_01990	COG0786	glutamate:sodium symporter activity
KO461_01995	COG2205	protein histidine kinase activity
KO461_02000	COG0745	RESPONSE REGULATOR receiver
KO461_02005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KO461_02015	COG3082	Protein of unknown function (DUF1414)
KO461_02020	COG3083	sulfuric ester hydrolase activity
KO461_02025	COG0402	S-adenosylhomocysteine deaminase activity
KO461_02030	COG3956	TIGRFAM MazG family protein
KO461_02045	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KO461_02055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KO461_02060	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
KO461_02065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KO461_02080	COG0148	phosphopyruvate hydratase activity
KO461_02090	COG2991	Protein conserved in bacteria
KO461_02095	COG1477	protein flavinylation
KO461_02100	COG2871	sodium ion transport
KO461_02105	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_02110	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_02115	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
KO461_02130	COG0271	Belongs to the BolA IbaG family
KO461_02135	COG3056	Lipoprotein
KO461_02160	COG1194	a g-specific adenine glycosylase
KO461_02170	COG3171	Protein conserved in bacteria
KO461_02175	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_02180	COG1178	ABC-type Fe3 transport system permease component
KO461_02185	COG3842	ATPase activity
KO461_02200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KO461_02210	COG1561	YicC-like family, N-terminal region
KO461_02215	COG0354	folic acid binding
KO461_02230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KO461_02235	COG1381	Involved in DNA repair and RecF pathway recombination
KO461_02240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KO461_02245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KO461_02250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KO461_02260	COG0500	methyltransferase
KO461_02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KO461_02270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_02275	COG1309	transcriptional regulator
KO461_02280	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_02285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KO461_02300	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_02310	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KO461_02355	COG1309	transcriptional regulator
KO461_02370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO461_02375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KO461_02380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
KO461_02385	COG4972	Pilus assembly protein
KO461_02405	COG4796	Type ii and iii secretion system protein
KO461_02420	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KO461_02445	COG0653	protein targeting
KO461_02460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KO461_02470	COG2801	Transposase and inactivated derivatives
KO461_02480	COG0789	Transcriptional regulator
KO461_02485	COG4701	Protein of unknown function (DUF721)
KO461_02500	COG0494	nUDIX hydrolase
KO461_02505	COG1466	dna polymerase III delta subunit
KO461_02510	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
KO461_02525	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KO461_02530	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KO461_02535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KO461_02540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KO461_02545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO461_02565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KO461_02575	COG4221	oxidoreductase activity
KO461_02585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KO461_02590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KO461_02595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KO461_02600	COG4137	Cytochrome C assembly protein
KO461_02605	COG4536	flavin adenine dinucleotide binding
KO461_02610	COG0811	peptide transport
KO461_02615	COG0848	biopolymer transport protein
KO461_02625	COG4783	chaperone-mediated protein folding
KO461_02635	COG0814	amino acid
KO461_02660	COG0747	negative chemotaxis
KO461_02665	COG2853	Lipoprotein
KO461_02675	COG3501	Rhs element vgr protein
KO461_02700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KO461_02710	COG2966	Psort location CytoplasmicMembrane, score
KO461_02720	COG0545	Peptidyl-prolyl cis-trans isomerase
KO461_02725	COG0688	phosphatidylethanolamine metabolic process
KO461_02730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KO461_02745	COG0500	methyltransferase
KO461_02755	COG1399	metal-binding, possibly nucleic acid-binding protein
KO461_02765	COG0416	fatty acid biosynthetic process
KO461_02775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KO461_02780	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_02790	COG2814	Major facilitator Superfamily
KO461_02795	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KO461_02800	COG0513	Belongs to the DEAD box helicase family
KO461_02805	COG0799	negative regulation of ribosome biogenesis
KO461_02815	COG0768	penicillin binding
KO461_02820	COG0772	Belongs to the SEDS family
KO461_02825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_02825	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO461_02830	COG1686	Belongs to the peptidase S11 family
KO461_02860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO461_02865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO461_02870	COG0765	amino acid transport
KO461_02875	COG1126	abc transporter atp-binding protein
KO461_02880	COG2168	tRNA wobble position uridine thiolation
KO461_02890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KO461_02895	COG2964	Protein conserved in bacteria
KO461_02900	COG0545	Peptidyl-prolyl cis-trans isomerase
KO461_02910	COG0678	peroxiredoxin activity
KO461_02910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KO461_02915	COG0583	DNA-binding transcription factor activity
KO461_02920	COG1309	transcriptional regulator
KO461_02925	COG1132	(ABC) transporter
KO461_02930	COG4988	ABC transporter
KO461_02935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KO461_02940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KO461_02945	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
KO461_02955	COG1045	serine acetyltransferase
KO461_02965	COG1494	fructose-1,6-bisphosphatase
KO461_02975	COG0716	FMN binding
KO461_02985	COG0702	epimerase
KO461_02990	COG1733	regulation of RNA biosynthetic process
KO461_03000	COG3312	ion transport
KO461_03020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KO461_03030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KO461_03045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KO461_03050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KO461_03060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KO461_03070	COG1349	DNA-binding transcription factor activity
KO461_03105	COG3501	Rhs element vgr protein
KO461_03205	COG0459	protein refolding
KO461_03210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KO461_03220	COG1027	Aspartate ammonia-lyase
KO461_03225	COG0859	PFAM glycosyl transferase family 9
KO461_03235	COG3716	PTS system mannose fructose sorbose family IID component
KO461_03240	COG3715	PTS system
KO461_03245	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_03245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_03250	COG2814	Major facilitator Superfamily
KO461_03255	COG2207	Transcriptional regulator
KO461_03255	COG1609	Transcriptional regulator
KO461_03260	COG1757	Na H antiporter
KO461_03270	COG4214	carbohydrate transport
KO461_03275	COG1129	ABC transporter
KO461_03285	COG2115	Belongs to the xylose isomerase family
KO461_03290	COG1070	Carbohydrate kinase
KO461_03300	COG0582	viral genome integration into host DNA
KO461_03350	COG3561	AntA/AntB antirepressor
KO461_03390	COG3070	regulator of competence-specific genes
KO461_03395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KO461_03405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KO461_03410	COG3850	Histidine kinase
KO461_03415	COG3062	negative regulation of establishment of protein localization
KO461_03420	COG0243	molybdopterin cofactor binding
KO461_03425	COG0437	4 iron, 4 sulfur cluster binding
KO461_03430	COG0348	domain, Protein
KO461_03435	COG3043	anaerobic respiration
KO461_03440	COG3005	denitrification pathway
KO461_03445	COG0754	glutathionylspermidine amidase activity
KO461_03450	COG0859	PFAM glycosyl transferase family 9
KO461_03460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO461_03470	COG0737	Belongs to the 5'-nucleotidase family
KO461_03495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_03500	COG1028	Short-chain dehydrogenase reductase Sdr
KO461_03510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_03565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO461_03590	COG1011	Hydrolase
KO461_03600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KO461_03605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KO461_03625	COG1596	polysaccharide export
KO461_03625	COG1555	photosystem II stabilization
KO461_03630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KO461_03635	COG0561	phosphatase activity
KO461_03640	COG1040	competence protein
KO461_03655	COG1114	Component of the transport system for branched-chain amino acids
KO461_03680	COG4804	nuclease activity
KO461_03690	COG4545	Glutaredoxin-related protein
KO461_03705	COG3381	protein complex oligomerization
KO461_03710	COG3302	dmso reductase anchor subunit
KO461_03715	COG0437	4 iron, 4 sulfur cluster binding
KO461_03730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO461_03730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO461_03740	COG5645	(Lipo)protein
KO461_03745	COG0210	DNA helicase
KO461_03770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KO461_03775	COG0110	maltose O-acetyltransferase activity
KO461_03780	COG1238	metal cluster binding
KO461_03815	COG2801	Transposase and inactivated derivatives
KO461_03870	COG2095	MarC family integral membrane protein
KO461_03875	COG0488	(ABC) transporter
KO461_03880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KO461_03885	COG2137	regulation of response to DNA damage stimulus
KO461_03890	COG0251	oxidation-reduction process
KO461_03900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KO461_03925	COG2826	transposase and inactivated derivatives, IS30 family
KO461_03955	COG0513	Belongs to the DEAD box helicase family
KO461_03965	COG3201	nicotinamide mononucleotide transporter
KO461_03975	COG3501	Rhs element vgr protein
KO461_03980	COG3078	GTPase activator activity
KO461_03990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO461_03995	COG0456	acetyltransferase
KO461_04005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KO461_04030	COG0511	ligase activity, forming carbon-carbon bonds
KO461_04035	COG0439	Biotin carboxylase
KO461_04045	COG4783	chaperone-mediated protein folding
KO461_04050	COG3924	membrane
KO461_04055	COG4145	pantothenate transmembrane transporter activity
KO461_04060	COG2184	nucleotidyltransferase activity
KO461_04085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KO461_04090	COG1115	amino acid carrier protein
KO461_04100	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KO461_04105	COG0237	dephospho-CoA kinase activity
KO461_04105	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KO461_04110	COG2801	Transposase and inactivated derivatives
KO461_04150	COG1181	Belongs to the D-alanine--D-alanine ligase family
KO461_04150	COG2918	glutathione biosynthetic process
KO461_04155	COG2194	sulfuric ester hydrolase activity
KO461_04160	COG0740	serine-type endopeptidase activity
KO461_04180	COG3739	integral membrane protein
KO461_04185	COG2217	Heavy metal translocating P-type atpase
KO461_04190	COG2608	mercury ion transmembrane transporter activity
KO461_04210	COG2932	Transcriptional regulator
KO461_04230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KO461_04250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO461_04300	COG1459	type II secretion system
KO461_04310	COG4969	Belongs to the N-Me-Phe pilin family
KO461_04315	COG3023	N-Acetylmuramoyl-L-alanine amidase
KO461_04320	COG2731	YhcH YjgK YiaL family protein
KO461_04330	COG4785	May be involved in cell division
KO461_04335	COG0513	Belongs to the DEAD box helicase family
KO461_04345	COG2801	Transposase and inactivated derivatives
KO461_04350	COG3835	regulator
KO461_04355	COG2610	gluconate transmembrane transporter activity
KO461_04360	COG1929	Belongs to the glycerate kinase type-1 family
KO461_04365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KO461_04370	COG0312	modulator of DNA gyrase
KO461_04375	COG3028	Belongs to the UPF0307 family
KO461_04380	COG0471	metal ion transport
KO461_04390	COG1575	Belongs to the MenA family. Type 1 subfamily
KO461_04395	COG1720	tRNA m6t6A37 methyltransferase activity
KO461_04425	COG2177	Part of the ABC transporter FtsEX involved in
KO461_04430	COG2884	Cell division ATP-binding protein ftsE
KO461_04435	COG0552	protein localization to endoplasmic reticulum
KO461_04440	COG0742	ribosomal rna small subunit methyltransferase
KO461_04445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_04445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_04450	COG3715	PTS system
KO461_04455	COG3716	PTS system mannose fructose sorbose family IID component
KO461_04460	COG0561	phosphatase activity
KO461_04465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KO461_04480	COG1649	PFAM Uncharacterised BCR, COG1649
KO461_04480	COG0726	polysaccharide deacetylase
KO461_04485	COG1215	transferase activity, transferring glycosyl groups
KO461_04495	COG2271	Major facilitator Superfamily
KO461_04520	COG2801	Transposase and inactivated derivatives
KO461_04540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KO461_04550	COG1758	RNA polymerase activity
KO461_04555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KO461_04565	COG3161	chorismate lyase activity
KO461_04595	COG2826	transposase and inactivated derivatives, IS30 family
KO461_04660	COG4964	Belongs to the GSP D family
KO461_04685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KO461_04695	COG1444	tRNA N-acetyltransferase activity
KO461_04705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KO461_04715	COG1126	abc transporter atp-binding protein
KO461_04720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO461_04725	COG4215	(ABC) transporter
KO461_04730	COG4160	amino acid transport
KO461_04735	COG1966	Carbon starvation protein
KO461_04750	COG3116	cell division
KO461_04755	COG0768	penicillin binding
KO461_04765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KO461_04785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KO461_04800	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KO461_04805	COG0849	cell division
KO461_04810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KO461_04820	COG0077	Prephenate dehydratase
KO461_04820	COG1605	Chorismate mutase
KO461_04825	COG0326	Molecular chaperone. Has ATPase activity
KO461_04830	COG1393	Belongs to the ArsC family
KO461_04840	COG1876	peptidase activity
KO461_04845	COG0494	nUDIX hydrolase
KO461_04850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KO461_04890	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
KO461_04900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KO461_04905	COG1053	succinate dehydrogenase
KO461_04915	COG1120	ATPase activity
KO461_04920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_04925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_04930	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KO461_04935	COG1408	metallophosphoesterase
KO461_04945	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KO461_04950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KO461_04955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO461_04970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO461_04980	COG0741	lytic transglycosylase activity
KO461_04985	COG2350	Protein conserved in bacteria
KO461_04990	COG1607	acyl-coa hydrolase
KO461_05005	COG3047	cAMP biosynthetic process
KO461_05010	COG0497	DNA recombination
KO461_05020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KO461_05030	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KO461_05030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO461_05035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO461_05040	COG0784	Response regulator, receiver
KO461_05040	COG2198	Histidine kinase
KO461_05040	COG5002	protein histidine kinase activity
KO461_05045	COG4211	Belongs to the binding-protein-dependent transport system permease family
KO461_05050	COG1129	ABC transporter
KO461_05055	COG1879	ABC-type sugar transport system periplasmic component
KO461_05060	COG1609	Transcriptional regulator
KO461_05065	COG1085	galactose-1-phosphate uridylyltransferase
KO461_05075	COG2017	converts alpha-aldose to the beta-anomer
KO461_05095	COG0471	metal ion transport
KO461_05100	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
KO461_05100	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KO461_05105	COG3051	citrate lyase alpha subunit
KO461_05110	COG2301	Belongs to the HpcH HpaI aldolase family
KO461_05120	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
KO461_05125	COG4535	Mg2 and Co2 transporter CorC
KO461_05145	COG0105	UTP biosynthetic process
KO461_05165	COG4942	peptidase
KO461_05165	COG1388	LysM domain
KO461_05175	COG1238	metal cluster binding
KO461_05205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KO461_05220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KO461_05240	COG1285	pathogenesis
KO461_05255	COG2826	transposase and inactivated derivatives, IS30 family
KO461_05300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO461_05300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO461_05300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KO461_05305	COG1105	Belongs to the carbohydrate kinase PfkB family
KO461_05310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_05310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_05320	COG0746	molybdenum cofactor guanylyltransferase activity
KO461_05325	COG3084	Protein conserved in bacteria
KO461_05330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_05335	COG3085	chromosome segregation
KO461_05375	COG0561	phosphatase activity
KO461_05385	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KO461_05395	COG2610	gluconate transmembrane transporter activity
KO461_05400	COG3622	Belongs to the hyi family
KO461_05405	COG0235	Class ii aldolase
KO461_05410	COG3395	kinase activity
KO461_05415	COG2084	Dehydrogenase
KO461_05420	COG1349	DNA-binding transcription factor activity
KO461_05425	COG0347	Belongs to the P(II) protein family
KO461_05430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KO461_05435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KO461_05440	COG0470	DNA polymerase III
KO461_05445	COG0084	hydrolase, TatD family'
KO461_05455	COG1253	flavin adenine dinucleotide binding
KO461_05460	COG3293	Transposase
KO461_05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KO461_05485	COG4942	peptidase
KO461_05490	COG2861	carbohydrate metabolic process
KO461_05495	COG0606	chelatase, subunit chli
KO461_05540	COG0210	DNA helicase
KO461_05560	COG0606	chelatase, subunit chli
KO461_05570	COG2990	Protein conserved in bacteria
KO461_05575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KO461_05595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KO461_05655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KO461_05670	COG0084	hydrolase, TatD family'
KO461_05675	COG0602	queuosine metabolic process
KO461_05680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KO461_05680	COG1328	CTP reductase activity
KO461_05690	COG1022	Amp-dependent synthetase and ligase
KO461_05695	COG0587	DNA-directed DNA polymerase activity
KO461_05715	COG0753	catalase activity
KO461_05720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KO461_05725	COG0165	Argininosuccinate lyase
KO461_05765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_05770	COG1879	ABC-type sugar transport system periplasmic component
KO461_05775	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_05785	COG1869	D-ribose catabolic process
KO461_05795	COG0730	response to heat
KO461_05810	COG0590	tRNA wobble adenosine to inosine editing
KO461_05840	COG3501	Rhs element vgr protein
KO461_05845	COG0489	protein tyrosine kinase activity
KO461_05850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO461_05850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO461_05855	COG2975	iron-sulfur cluster assembly
KO461_05860	COG0633	Ferredoxin
KO461_05865	COG0443	Heat shock 70 kDa protein
KO461_05880	COG0822	iron-sulfur transferase activity
KO461_05890	COG1959	2 iron, 2 sulfur cluster binding
KO461_05895	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
KO461_05950	COG0626	cystathionine gamma-synthase activity
KO461_05955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO461_05970	COG1530	ribonuclease E activity
KO461_05980	COG2259	Doxx family
KO461_05990	COG1611	Belongs to the LOG family
KO461_06000	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KO461_06005	COG0745	RESPONSE REGULATOR receiver
KO461_06010	COG4608	Belongs to the ABC transporter superfamily
KO461_06015	COG0444	Belongs to the ABC transporter superfamily
KO461_06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KO461_06025	COG0601	transmembrane transport
KO461_06030	COG4166	transmembrane transport
KO461_06040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KO461_06045	COG0697	spore germination
KO461_06050	COG0697	spore germination
KO461_06065	COG0142	geranyltranstransferase activity
KO461_06070	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KO461_06075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KO461_06090	COG2056	Na+-H+ antiporter family
KO461_06095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KO461_06100	COG0346	lactoylglutathione lyase activity
KO461_06110	COG2271	Major facilitator Superfamily
KO461_06125	COG1755	Isoprenylcysteine carboxyl methyltransferase
KO461_06130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KO461_06135	COG2801	Transposase and inactivated derivatives
KO461_06150	COG0494	nUDIX hydrolase
KO461_06155	COG0217	transcriptional regulatory protein
KO461_06185	COG1271	oxidase subunit
KO461_06190	COG1294	oxidase, subunit
KO461_06205	COG0824	Thioesterase
KO461_06210	COG0811	peptide transport
KO461_06215	COG0848	biopolymer transport protein
KO461_06220	COG3064	Membrane
KO461_06250	COG2165	general secretion pathway protein
KO461_06255	COG4795	General secretion pathway protein
KO461_06270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KO461_06275	COG0456	acetyltransferase
KO461_06280	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
KO461_06285	COG2813	Specifically methylates the guanine in position
KO461_06300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KO461_06310	COG2994	toxin metabolic process
KO461_06315	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
KO461_06320	COG2274	protein secretion by the type I secretion system
KO461_06325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_06335	COG0246	Mannitol dehydrogenase
KO461_06340	COG3722	fumarate hydratase activity
KO461_06345	COG0673	inositol 2-dehydrogenase activity
KO461_06355	COG3962	Belongs to the TPP enzyme family
KO461_06360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO461_06390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KO461_06415	COG3623	hexulose-6-phosphate isomerase
KO461_06420	COG0235	Class ii aldolase
KO461_06450	COG0814	amino acid
KO461_06460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KO461_06465	COG0778	Nitroreductase
KO461_06480	COG2268	Band 7 protein
KO461_06485	COG0114	fumarate hydratase activity
KO461_06490	COG2927	DNA polymerase III (CHI subunit)
KO461_06520	COG2814	Major facilitator Superfamily
KO461_06525	COG1566	PFAM secretion protein HlyD family protein
KO461_06530	COG0783	Belongs to the Dps family
KO461_06540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KO461_06545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KO461_06550	COG0602	queuosine metabolic process
KO461_06555	COG0720	synthase
KO461_06615	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO461_06620	COG1012	belongs to the aldehyde dehydrogenase family
KO461_06620	COG1454	alcohol dehydrogenase
KO461_06630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO461_06635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO461_06640	COG1862	Preprotein translocase
KO461_06650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KO461_06700	COG0826	peptidase U32
KO461_06715	COG2026	Addiction module toxin, RelE StbE family
KO461_06735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KO461_06740	COG0328	RNA-DNA hybrid ribonuclease activity
KO461_06745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KO461_06765	COG1620	l-lactate permease
KO461_06785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KO461_06790	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KO461_06795	COG0617	tRNA 3'-terminal CCA addition
KO461_06800	COG4991	sh3 domain protein
KO461_06805	COG0306	phosphate transporter
KO461_06810	COG1392	Phosphate transport regulator
KO461_06815	COG3025	triphosphatase activity
KO461_06820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KO461_06825	COG0563	adenylate kinase activity
KO461_06830	COG2814	Major facilitator Superfamily
KO461_06835	COG0375	protein maturation
KO461_06840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KO461_06845	COG3152	Membrane
KO461_06850	COG2252	PERMEase
KO461_06865	COG0825	malonyl-CoA metabolic process
KO461_06870	COG2351	hydroxyisourate hydrolase activity
KO461_06885	COG3041	Addiction module toxin RelE StbE family
KO461_06890	COG3077	Addiction module antitoxin, RelB DinJ family
KO461_06895	COG3069	C4-dicarboxylate transmembrane transporter activity
KO461_06900	COG2801	Transposase and inactivated derivatives
KO461_06915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_06920	COG0785	Cytochrome C biogenesis protein
KO461_06925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KO461_06925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KO461_06930	COG0288	reversible hydration of carbon dioxide
KO461_06935	COG2823	Periplasmic or secreted lipoprotein
KO461_06940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
KO461_06945	COG0792	nuclease activity
KO461_06955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KO461_06965	COG1252	NADH dehydrogenase
KO461_06975	COG0616	signal peptide processing
KO461_06985	COG0625	glutathione transferase activity
KO461_06990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO461_06995	COG0187	DNA topoisomerase II activity
KO461_07005	COG0488	(ABC) transporter
KO461_07010	COG3683	transport system, periplasmic component
KO461_07015	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
KO461_07035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO461_07040	COG3105	Protein conserved in bacteria
KO461_07045	COG1944	ATP diphosphatase activity
KO461_07055	COG3422	double-strand break repair
KO461_07060	COG2190	(PTS) system
KO461_07060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_07060	COG1263	PTS System
KO461_07065	COG2226	methyltransferase
KO461_07070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO461_07080	COG1940	carbohydrate kinase activity
KO461_07080	COG1846	Transcriptional regulator
KO461_07170	COG3501	Rhs element vgr protein
KO461_07175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO461_07175	COG2190	(PTS) system
KO461_07175	COG1263	PTS System
KO461_07180	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
KO461_07185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KO461_07185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KO461_07190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KO461_07195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
KO461_07205	COG1737	Transcriptional regulator
KO461_07210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KO461_07215	COG0363	glucosamine-6-phosphate deaminase activity
KO461_07220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KO461_07225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KO461_07240	COG0277	FAD linked oxidase domain protein
KO461_07240	COG0247	lactate metabolic process
KO461_07260	COG2363	Small membrane protein
KO461_07265	COG1643	Atp-dependent helicase
KO461_07275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KO461_07285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO461_07290	COG0577	efflux transmembrane transporter activity
KO461_07290	COG1136	(ABC) transporter
KO461_07300	COG0577	efflux transmembrane transporter activity
KO461_07300	COG1136	(ABC) transporter
KO461_07315	COG0672	)-iron permease
KO461_07320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO461_07330	COG0316	Belongs to the HesB IscA family
KO461_07335	COG0024	Methionine aminopeptidase
KO461_07345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KO461_07350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KO461_07395	COG4172	Belongs to the ABC transporter superfamily
KO461_07400	COG4172	Belongs to the ABC transporter superfamily
KO461_07405	COG4171	peptide transport system, permease
KO461_07410	COG4168	peptide transport system, permease
KO461_07415	COG4166	transmembrane transport
KO461_07420	COG3106	COG3106 Predicted ATPase
KO461_07430	COG3283	Transcriptional regulator of aromatic amino acids metabolism
KO461_07435	COG1923	regulation of RNA biosynthetic process
KO461_07445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KO461_07450	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO461_07450	COG1388	LysM domain
KO461_07455	COG0802	atpase or kinase
KO461_07465	COG2246	polysaccharide biosynthetic process
KO461_07475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KO461_07485	COG2194	sulfuric ester hydrolase activity
KO461_07520	COG2337	Toxic component of a toxin-antitoxin (TA) module
KO461_07535	COG3021	interspecies interaction between organisms
KO461_07610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_07615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KO461_07620	COG2190	(PTS) system
KO461_07625	COG0339	signal peptide processing
KO461_07630	COG2832	Protein of unknown function (DUF454)
KO461_07635	COG4166	transmembrane transport
KO461_07655	COG3501	Rhs element vgr protein
KO461_07660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO461_07670	COG0512	Glutamine amidotransferase of anthranilate synthase
KO461_07675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO461_07700	COG2801	Transposase and inactivated derivatives
KO461_07715	COG2932	Transcriptional regulator
KO461_07730	COG0517	IMP dehydrogenase activity
KO461_07730	COG0516	GMP reductase activity
KO461_07805	COG0195	Participates in both transcription termination and antitermination
KO461_07820	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KO461_07835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KO461_07845	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KO461_07850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
KO461_07860	COG3177	Filamentation induced by cAMP protein fic
KO461_07870	COG3842	ATPase activity
KO461_07875	COG1175	transmembrane transport
KO461_07880	COG0395	ABC-type sugar transport system, permease component
KO461_07890	COG0322	excinuclease ABC activity
KO461_07900	COG2835	tetraacyldisaccharide 4'-kinase activity
KO461_07905	COG1663	tetraacyldisaccharide 4'-kinase activity
KO461_07910	COG1132	(ABC) transporter
KO461_07915	COG2333	competence protein COMEC
KO461_07915	COG0658	competence protein
KO461_07920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KO461_07925	COG0617	tRNA 3'-terminal CCA addition
KO461_07930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KO461_07940	COG0857	belongs to the CobB CobQ family
KO461_07940	COG0280	phosphate acetyltransferase
KO461_07945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KO461_07950	COG3092	negative regulation of chromosome organization
KO461_07955	COG1286	toxin biosynthetic process
KO461_07960	COG1640	4-alpha-glucanotransferase
KO461_07965	COG0058	SHG alpha-glucan phosphorylase activity
KO461_07970	COG2909	trisaccharide binding
KO461_07980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KO461_07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO461_07990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO461_07995	COG0778	Nitroreductase
KO461_08000	COG0616	signal peptide processing
KO461_08010	COG0009	L-threonylcarbamoyladenylate synthase
KO461_08020	COG0583	DNA-binding transcription factor activity
KO461_08040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KO461_08045	COG2949	membrane
KO461_08055	COG3501	Rhs element vgr protein
KO461_08075	COG3718	enzyme involved in inositol metabolism
KO461_08085	COG2271	Major facilitator Superfamily
KO461_08105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KO461_08115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_08120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KO461_08125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO461_08130	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KO461_08135	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KO461_08140	COG0310	cobalt ion transport
KO461_08145	COG0310	cobalt ion transport
KO461_08150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KO461_08155	COG1122	ATPase activity
KO461_08160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KO461_08165	COG0409	Hydrogenase expression formation protein
KO461_08170	COG0309	Hydrogenase expression formation protein (HypE)
KO461_08190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KO461_08195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KO461_08200	COG0795	lipopolysaccharide-transporting ATPase activity
KO461_08205	COG0795	lipopolysaccharide-transporting ATPase activity
KO461_08215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KO461_08220	COG4149	molybdate abc transporter
KO461_08225	COG0725	ABC transporter, periplasmic molybdate-binding protein
KO461_08230	COG2005	Transcriptional regulator
KO461_08235	COG0471	metal ion transport
KO461_08245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO461_08250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO461_08250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO461_08255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KO461_08265	COG0583	DNA-binding transcription factor activity
KO461_08270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO461_08280	COG0039	L-malate dehydrogenase activity
KO461_08285	COG1438	arginine binding
KO461_08290	COG1090	epimerase
KO461_08295	COG4657	Part of a membrane complex involved in electron transport
KO461_08325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KO461_08330	COG0733	neurotransmitter:sodium symporter activity
KO461_08335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_08345	COG0739	heme binding
KO461_08350	COG4604	ABC transporter, ATP-binding protein
KO461_08355	COG4605	iron ion homeostasis
KO461_08360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_08365	COG4607	ABC-type enterochelin transport system periplasmic component
KO461_08370	COG0737	Belongs to the 5'-nucleotidase family
KO461_08390	COG0642	Histidine kinase
KO461_08395	COG0405	Gamma-glutamyltransferase
KO461_08410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO461_08415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KO461_08420	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
KO461_08475	COG0583	DNA-binding transcription factor activity
KO461_08480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KO461_08485	COG1687	branched-chain amino acid
KO461_08490	COG0612	Peptidase, M16
KO461_08495	COG4771	TonB-dependent receptor
KO461_08500	COG2990	Protein conserved in bacteria
KO461_08510	COG0539	negative regulation of cytoplasmic translation
KO461_08515	COG0776	regulation of translation
KO461_08520	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
KO461_08525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
KO461_08535	COG0023	Translation Initiation Factor
KO461_08540	COG3094	Invasion gene expression up-regulator, SirB
KO461_08545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO461_08550	COG0735	belongs to the Fur family
KO461_08555	COG0716	FMN binding
KO461_08560	COG0596	Alpha beta hydrolase
KO461_08565	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
KO461_08570	COG0318	PFAM AMP-dependent synthetase and ligase
KO461_08575	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KO461_08575	COG3264	Mechanosensitive ion channel
KO461_08580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KO461_08585	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
KO461_08590	COG0730	response to heat
KO461_08595	COG1560	Kdo2-lipid A biosynthetic process
KO461_08605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KO461_08615	COG0463	Glycosyl transferase, family 2
KO461_08625	COG0251	oxidation-reduction process
KO461_08635	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KO461_08640	COG1757	Na H antiporter
KO461_08645	COG2916	Histone family protein nucleoid-structuring protein H-NS
KO461_08650	COG0788	formyltetrahydrofolate deformylase activity
KO461_08660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KO461_08665	COG3101	peptidyl-lysine hydroxylation
KO461_08670	COG3842	ATPase activity
KO461_08675	COG1178	ABC-type Fe3 transport system permease component
KO461_08680	COG3842	ATPase activity
KO461_08715	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
KO461_08720	COG3098	single-species biofilm formation
KO461_08735	COG1278	Cold shock
KO461_08745	COG1067	ATP-dependent peptidase activity
KO461_08750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KO461_08760	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KO461_08765	COG1074	ATP-dependent DNA helicase activity
KO461_08770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KO461_08790	COG0101	tRNA pseudouridine synthase activity
KO461_08805	COG0471	metal ion transport
KO461_08810	COG2315	Protein conserved in bacteria
KO461_08815	COG0243	molybdopterin cofactor binding
KO461_08820	COG3005	denitrification pathway
KO461_08840	COG3293	Transposase
KO461_08875	COG1346	cytolysis
KO461_08890	COG3657	addiction module killer protein
KO461_08895	COG0488	(ABC) transporter
KO461_08945	COG1523	belongs to the glycosyl hydrolase 13 family
KO461_08960	COG0058	SHG alpha-glucan phosphorylase activity
KO461_08965	COG0586	Pfam SNARE associated Golgi protein
KO461_08970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KO461_08980	COG1686	Belongs to the peptidase S11 family
KO461_08985	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
KO461_08995	COG0318	PFAM AMP-dependent synthetase and ligase
KO461_08995	COG0204	Acyl-transferase
KO461_09000	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
KO461_09005	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
KO461_09010	COG0697	spore germination
KO461_09015	COG2925	Exonuclease
KO461_09020	COG1528	Iron-storage protein
KO461_09025	COG1528	Iron-storage protein
KO461_09035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KO461_09040	COG0589	response to stress
KO461_09045	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
KO461_09055	COG0613	PHP domain protein
KO461_09060	COG0167	dihydroorotate dehydrogenase activity
KO461_09065	COG0308	aminopeptidase N
KO461_09070	COG1448	Aminotransferase
KO461_09080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_09085	COG1129	ABC transporter
KO461_09085	COG0842	Transport permease protein
KO461_09090	COG0842	Transport permease protein
KO461_09105	COG0791	NLP P60 protein
KO461_09120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KO461_09135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KO461_09135	COG0517	IMP dehydrogenase activity
KO461_09140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KO461_09145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KO461_09155	COG1942	4-Oxalocrotonate Tautomerase
KO461_09170	COG3093	addiction module antidote protein HigA
KO461_09175	COG0134	indole-3-glycerol-phosphate synthase activity
KO461_09175	COG0135	phosphoribosylanthranilate isomerase activity
KO461_09185	COG0298	carbon dioxide binding
KO461_09200	COG3630	sodium ion export across plasma membrane
KO461_09225	COG0133	tryptophan synthase activity
KO461_09235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_09245	COG0469	pyruvate kinase activity
KO461_09280	COG2390	Transcriptional regulator
KO461_09285	COG1070	Carbohydrate kinase
KO461_09290	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KO461_09295	COG1940	carbohydrate kinase activity
KO461_09305	COG2969	positive regulation of protein catabolic process
KO461_09315	COG0314	molybdopterin synthase activity
KO461_09320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KO461_09330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KO461_09340	COG3293	Transposase
KO461_09400	COG3293	Transposase
KO461_09415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_09420	COG1120	ATPase activity
KO461_09430	COG3585	molybdate ion transport
KO461_09440	COG1120	ATPase activity
KO461_09445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO461_09450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO461_09460	COG4774	siderophore transport
KO461_09475	COG1525	nuclease
KO461_09480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KO461_09485	COG2166	iron-sulfur cluster assembly
KO461_09490	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
KO461_09490	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KO461_09495	COG1560	Kdo2-lipid A biosynthetic process
KO461_09500	COG3381	protein complex oligomerization
KO461_09505	COG2249	NAD(P)H dehydrogenase (quinone) activity
KO461_09515	COG0330	HflC and HflK could
KO461_09540	COG1858	cytochrome C peroxidase
KO461_09545	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
KO461_09555	COG3065	identical protein binding
KO461_09560	COG1214	PFAM Peptidase M22, glycoprotease
KO461_09565	COG1199	ATP-dependent helicase activity
KO461_09570	COG0676	glucose-6-phosphate 1-epimerase activity
KO461_09580	COG4580	involved in the transport of maltose and maltodextrins
KO461_09585	COG3842	ATPase activity
KO461_09590	COG2182	Extracellular solute-binding protein
KO461_09600	COG3833	ABC-type maltose transport systems, permease component
KO461_09605	COG0366	Alpha amylase catalytic
KO461_09610	COG3842	ATPase activity
KO461_09620	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_09630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_09640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO461_09645	COG0633	Ferredoxin
KO461_09655	COG1280	lysine exporter protein (LysE YggA)
KO461_09660	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KO461_09665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KO461_09675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KO461_09685	COG0166	Belongs to the GPI family
KO461_09695	COG0305	Participates in initiation and elongation during chromosome replication
KO461_09700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KO461_09705	COG4591	ABC-type transport system involved in lipoprotein release permease component
KO461_09710	COG1136	(ABC) transporter
KO461_09715	COG4591	ABC-type transport system involved in lipoprotein release permease component
KO461_09770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO461_09775	COG1136	(ABC) transporter
KO461_09775	COG0577	efflux transmembrane transporter activity
KO461_09780	COG1538	Outer membrane efflux protein
KO461_09790	COG2824	Alkylphosphonate utilization operon protein PhnA
KO461_09800	COG0564	pseudouridine synthase activity
KO461_09805	COG2431	L-lysine efflux transmembrane transporter activity
KO461_09810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO461_09815	COG0406	alpha-ribazole phosphatase activity
KO461_09820	COG0285	dihydrofolate synthase activity
KO461_09835	COG0142	geranyltranstransferase activity
KO461_09845	COG1349	DNA-binding transcription factor activity
KO461_09850	COG1063	alcohol dehydrogenase
KO461_09860	COG3684	Belongs to the aldolase LacD family
KO461_09870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KO461_09875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KO461_09895	COG2801	Transposase and inactivated derivatives
KO461_09900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KO461_09905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KO461_09915	COG2062	phosphohistidine phosphatase, SixA
KO461_09930	COG3100	YcgL domain-containing protein
KO461_09940	COG0791	NLP P60 protein
KO461_09950	COG2890	protein-(glutamine-N5) methyltransferase activity
KO461_09955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KO461_09960	COG3133	Outer membrane lipoprotein
KO461_09975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KO461_09980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KO461_09990	COG0307	riboflavin synthase, alpha
KO461_09995	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KO461_10000	COG3657	addiction module killer protein
KO461_10005	COG1534	Rna-binding protein
KO461_10010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KO461_10015	COG2027	D-alanyl-D-alanine carboxypeptidase
KO461_10025	COG0303	'Molybdopterin
KO461_10030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KO461_10040	COG3118	belongs to the thioredoxin family
KO461_10045	COG0492	ferredoxin-NADP+ reductase activity
KO461_10050	COG4988	ABC transporter
KO461_10055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KO461_10065	COG1946	Acyl-CoA thioesterase
KO461_10070	COG0515	serine threonine protein kinase
KO461_10090	COG0671	phosphoesterase, PA-phosphatase related
KO461_10105	COG1088	dTDP-glucose 4,6-dehydratase activity
KO461_10110	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
KO461_10115	COG0708	Exodeoxyribonuclease III
KO461_10140	COG1216	Glycosyl transferase, family 2
KO461_10145	COG2246	polysaccharide biosynthetic process
KO461_10190	COG2951	lytic endotransglycosylase activity
KO461_10195	COG1216	Glycosyl transferase, family 2
KO461_10200	COG1216	Glycosyl transferase, family 2
KO461_10210	COG3306	glycosyltransferase involved in LPS biosynthesis
KO461_10220	COG5039	Polysaccharide pyruvyl transferase
KO461_10225	COG2161	toxin-antitoxin pair type II binding
KO461_10230	COG4115	mRNA cleavage
KO461_10235	COG1434	Gram-negative-bacterium-type cell wall biogenesis
KO461_10240	COG1793	dna ligase
KO461_10245	COG0210	DNA helicase
KO461_10250	COG2610	gluconate transmembrane transporter activity
KO461_10255	COG3265	gluconokinase activity
KO461_10260	COG1609	Transcriptional regulator
KO461_10275	COG0437	4 iron, 4 sulfur cluster binding
KO461_10280	COG2864	formate dehydrogenase
KO461_10285	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
KO461_10290	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KO461_10295	COG0651	ATP synthesis coupled electron transport
KO461_10300	COG0650	Formate hydrogenlyase subunit 4
KO461_10305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KO461_10310	COG4237	Hydrogenase 4 membrane
KO461_10315	COG0651	ATP synthesis coupled electron transport
KO461_10320	COG3261	NADH dehydrogenase
KO461_10320	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
KO461_10325	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KO461_10330	COG3260	NADH ubiquinone oxidoreductase 20
KO461_10340	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KO461_10350	COG3383	formate dehydrogenase (NAD+) activity
KO461_10355	COG3383	formate dehydrogenase (NAD+) activity
KO461_10380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KO461_10390	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO461_10395	COG0567	Dehydrogenase, E1 component
KO461_10400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO461_10405	COG3108	Peptidase M15
KO461_10410	COG2989	Protein conserved in bacteria
KO461_10415	COG0793	Belongs to the peptidase S41A family
KO461_10420	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
KO461_10425	COG2995	paraquat-inducible protein a
KO461_10430	COG3008	intermembrane lipid transfer
KO461_10440	COG3842	ATPase activity
KO461_10445	COG1176	ABC-type spermidine putrescine transport system, permease component I
KO461_10450	COG1177	transmembrane transport
KO461_10455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KO461_10470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
KO461_10475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KO461_10490	COG1522	sequence-specific DNA binding
KO461_10500	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
KO461_10505	COG1178	ABC-type Fe3 transport system permease component
KO461_10510	COG4143	(ABC) transporter
KO461_10515	COG0351	phosphomethylpyrimidine kinase
KO461_10515	COG0351	phosphomethylpyrimidine kinase
KO461_10580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KO461_10595	COG2920	part of a sulfur-relay system
KO461_10605	COG1121	(ABC) transporter
KO461_10610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_10615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO461_10635	COG3304	Inner membrane component domain
KO461_10640	COG1289	transmembrane transporter activity
KO461_10655	COG3958	Transketolase
KO461_10660	COG3959	Transketolase, thiamine diphosphate binding domain
KO461_10695	COG3501	Rhs element vgr protein
KO461_10700	COG4953	penicillin-binding protein 1C
KO461_10705	COG2855	membrane
KO461_10720	COG0157	Belongs to the NadC ModD family
KO461_10730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KO461_10735	COG0725	ABC transporter, periplasmic molybdate-binding protein
KO461_10745	COG5339	Protein conserved in bacteria
KO461_10750	COG0443	Heat shock 70 kDa protein
KO461_10755	COG0484	heat shock protein binding
KO461_10760	COG2337	Toxic component of a toxin-antitoxin (TA) module
KO461_10775	COG0626	cystathionine gamma-synthase activity
KO461_10780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KO461_10800	COG2801	Transposase and inactivated derivatives
KO461_10810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KO461_10815	COG2999	glutathione oxidoreductase activity
KO461_10820	COG1530	ribonuclease E activity
KO461_10825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO461_10875	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_10880	COG1840	ABC-type Fe3 transport system, periplasmic component
KO461_10910	COG2860	membrane
KO461_10925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KO461_10935	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
KO461_10940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KO461_10945	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
KO461_10950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
KO461_10970	COG2914	Belongs to the UPF0125 (RnfH) family
KO461_10975	COG2850	peptidyl-arginine hydroxylation
KO461_10980	COG1570	exodeoxyribonuclease VII activity
KO461_10990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO461_10995	COG1137	ATPase activity
KO461_11000	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KO461_11005	COG3117	lipopolysaccharide transmembrane transporter activity
KO461_11010	COG1127	ABC transporter
KO461_11015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KO461_11020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KO461_11025	COG2854	intermembrane phospholipid transfer
KO461_11030	COG3113	response to antibiotic
KO461_11035	COG5007	Belongs to the BolA IbaG family
KO461_11045	COG3691	Protein conserved in bacteria
KO461_11055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KO461_11065	COG0861	Integral membrane protein TerC family
KO461_11075	COG1217	gtp-binding protein TYPA
KO461_11080	COG3266	domain, Protein
KO461_11080	COG3468	outer membrane autotransporter barrel domain protein
KO461_11085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KO461_11090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KO461_11105	COG0517	IMP dehydrogenase activity
KO461_11105	COG1125	glycine betaine transport
KO461_11110	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KO461_11120	COG0460	homoserine dehydrogenase
KO461_11120	COG0527	aspartate kinase activity
KO461_11135	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KO461_11140	COG2091	lysine biosynthetic process via aminoadipic acid
KO461_11145	COG0330	HflC and HflK could
KO461_11150	COG0330	HflC and HflK could
KO461_11160	COG4974	Belongs to the 'phage' integrase family
KO461_11165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KO461_11180	COG3266	domain, Protein
KO461_11180	COG3061	Opacity-associated protein A
KO461_11185	COG1509	lysine 2,3-aminomutase activity
KO461_11195	COG3033	Beta-eliminating lyase
KO461_11200	COG0814	amino acid
KO461_11205	COG2964	Protein conserved in bacteria
KO461_11210	COG5413	integral membrane protein
KO461_11220	COG0204	Acyl-transferase
KO461_11230	COG0697	spore germination
KO461_11235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KO461_11240	COG1882	Formate acetyltransferase
KO461_11245	COG2116	formate transmembrane transporter activity
KO461_11250	COG0537	adenosine 5'-monophosphoramidase activity
KO461_11290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KO461_11305	COG0681	Belongs to the peptidase S26 family