locus-tag	class	description
D11S_0003	COG2842	Transposition protein
D11S_0004	COG2801	Transposase and inactivated derivatives
D11S_0005	COG3423	Transcriptional regulator
D11S_0009	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D11S_0011	COG0688	phosphatidylethanolamine metabolic process
D11S_0012	COG0545	Peptidyl-prolyl cis-trans isomerase
D11S_0016	COG2966	Psort location CytoplasmicMembrane, score
D11S_0017	COG3610	response to peptide
D11S_0018	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D11S_0019	COG1253	flavin adenine dinucleotide binding
D11S_0022	COG0084	hydrolase, TatD family'
D11S_0023	COG0470	DNA polymerase III
D11S_0024	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D11S_0025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D11S_0026	COG0347	Belongs to the P(II) protein family
D11S_0027	COG1349	DNA-binding transcription factor activity
D11S_0028	COG2084	Dehydrogenase
D11S_0029	COG3395	kinase activity
D11S_0030	COG0235	Class ii aldolase
D11S_0031	COG3622	Belongs to the hyi family
D11S_0032	COG2610	gluconate transmembrane transporter activity
D11S_0034	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D11S_0036	COG0561	phosphatase activity
D11S_0041	COG3085	chromosome segregation
D11S_0042	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_0043	COG3084	Protein conserved in bacteria
D11S_0044	COG0746	molybdenum cofactor guanylyltransferase activity
D11S_0046	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_0046	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_0047	COG1105	Belongs to the carbohydrate kinase PfkB family
D11S_0048	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D11S_0048	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D11S_0048	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D11S_0056	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D11S_0061	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D11S_0065	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D11S_0066	COG0255	Belongs to the universal ribosomal protein uL29 family
D11S_0067	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D11S_0068	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D11S_0069	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D11S_0071	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D11S_0072	COG0089	rRNA binding
D11S_0073	COG0088	Forms part of the polypeptide exit tunnel
D11S_0074	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D11S_0075	COG0051	transcription antitermination factor activity, RNA binding
D11S_0076	COG0583	DNA-binding transcription factor activity
D11S_0077	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D11S_0078	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D11S_0079	COG2031	fatty acid transporter
D11S_0080	COG0183	Belongs to the thiolase family
D11S_0082	COG1288	antiporter activity
D11S_0083	COG0549	Belongs to the carbamate kinase family
D11S_0084	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D11S_0085	COG0038	chloride channel
D11S_0086	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D11S_0088	COG1522	sequence-specific DNA binding
D11S_0089	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D11S_0091	COG1393	Belongs to the ArsC family
D11S_0093	COG3036	rescue of stalled ribosome
D11S_0094	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D11S_0095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D11S_0096	COG2841	Protein conserved in bacteria
D11S_0099	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D11S_0101	COG0569	domain protein
D11S_0102	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D11S_0102	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D11S_0112	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D11S_0116	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D11S_0117	COG2990	Protein conserved in bacteria
D11S_0124	COG0210	DNA helicase
D11S_0131	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D11S_0139	COG2861	carbohydrate metabolic process
D11S_0140	COG4942	peptidase
D11S_0141	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D11S_0144	COG2853	Lipoprotein
D11S_0145	COG0747	negative chemotaxis
D11S_0152	COG0814	amino acid
D11S_0154	COG4783	chaperone-mediated protein folding
D11S_0155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D11S_0157	COG0552	protein localization to endoplasmic reticulum
D11S_0158	COG0742	ribosomal rna small subunit methyltransferase
D11S_0159	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_0159	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_0160	COG3715	PTS system
D11S_0161	COG3716	PTS system mannose fructose sorbose family IID component
D11S_0162	COG0561	phosphatase activity
D11S_0163	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D11S_0167	COG1649	PFAM Uncharacterised BCR, COG1649
D11S_0167	COG0726	polysaccharide deacetylase
D11S_0168	COG1215	transferase activity, transferring glycosyl groups
D11S_0171	COG2271	Major facilitator Superfamily
D11S_0177	COG0513	Belongs to the DEAD box helicase family
D11S_0180	COG3201	nicotinamide mononucleotide transporter
D11S_0184	COG1238	metal cluster binding
D11S_0185	COG0110	maltose O-acetyltransferase activity
D11S_0192	COG0210	DNA helicase
D11S_0193	COG5645	(Lipo)protein
D11S_0195	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D11S_0195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D11S_0198	COG0737	Belongs to the 5'-nucleotidase family
D11S_0201	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D11S_0203	COG0859	PFAM glycosyl transferase family 9
D11S_0204	COG0754	glutathionylspermidine amidase activity
D11S_0205	COG3005	denitrification pathway
D11S_0206	COG3043	anaerobic respiration
D11S_0207	COG0348	domain, Protein
D11S_0208	COG0437	4 iron, 4 sulfur cluster binding
D11S_0209	COG0243	molybdopterin cofactor binding
D11S_0210	COG3062	negative regulation of establishment of protein localization
D11S_0212	COG3850	Histidine kinase
D11S_0213	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D11S_0215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D11S_0216	COG3070	regulator of competence-specific genes
D11S_02215	COG2932	Transcriptional regulator
D11S_02225	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D11S_0225	COG0583	DNA-binding transcription factor activity
D11S_0226	COG2962	Rard protein
D11S_02275	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D11S_0229	COG0551	DNA topoisomerase type I activity
D11S_0234	COG0705	Rhomboid family
D11S_0235	COG1349	DNA-binding transcription factor activity
D11S_02375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D11S_0238	COG4178	(ABC) transporter
D11S_02385	COG1841	ribosomal large subunit assembly
D11S_0243	COG0233	cytoplasmic translational termination
D11S_02440	COG1879	ABC-type sugar transport system periplasmic component
D11S_0246	COG0575	Belongs to the CDS family
D11S_0249	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D11S_02490	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_0251	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D11S_0253	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D11S_02550	COG2246	polysaccharide biosynthetic process
D11S_0257	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D11S_02570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D11S_0259	COG4589	Belongs to the CDS family
D11S_02590	COG3550	peptidyl-serine autophosphorylation
D11S_0260	COG0521	Mo-molybdopterin cofactor biosynthetic process
D11S_02635	COG2351	hydroxyisourate hydrolase activity
D11S_02660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D11S_0267	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D11S_0269	COG0251	oxidation-reduction process
D11S_0270	COG2137	regulation of response to DNA damage stimulus
D11S_0271	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D11S_0273	COG2095	MarC family integral membrane protein
D11S_0278	COG2963	transposase activity
D11S_02780	COG3266	domain, Protein
D11S_02780	COG3468	outer membrane autotransporter barrel domain protein
D11S_0280	COG1349	DNA-binding transcription factor activity
D11S_0282	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D11S_0284	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D11S_02855	COG1943	Transposase
D11S_0288	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D11S_02885	COG3108	Peptidase M15
D11S_0289	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D11S_0290	COG0765	amino acid transport
D11S_0291	COG1126	abc transporter atp-binding protein
D11S_0292	COG2168	tRNA wobble position uridine thiolation
D11S_0294	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D11S_0295	COG2964	Protein conserved in bacteria
D11S_0296	COG0545	Peptidyl-prolyl cis-trans isomerase
D11S_0297	COG2900	Belongs to the SlyX family
D11S_0298	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D11S_0298	COG0678	peroxiredoxin activity
D11S_0299	COG0583	DNA-binding transcription factor activity
D11S_0300	COG1309	transcriptional regulator
D11S_0301	COG1132	(ABC) transporter
D11S_0302	COG4988	ABC transporter
D11S_0303	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D11S_0304	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D11S_0305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D11S_0307	COG1045	serine acetyltransferase
D11S_0310	COG1494	fructose-1,6-bisphosphatase
D11S_0312	COG0716	FMN binding
D11S_0314	COG0702	epimerase
D11S_0315	COG1733	regulation of RNA biosynthetic process
D11S_0317	COG3312	ion transport
D11S_0321	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D11S_0323	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D11S_0326	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D11S_0334	COG3716	PTS system mannose fructose sorbose family IID component
D11S_0335	COG3715	PTS system
D11S_0336	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_0336	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_0337	COG2814	Major facilitator Superfamily
D11S_0338	COG2207	Transcriptional regulator
D11S_0338	COG1609	Transcriptional regulator
D11S_0342	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D11S_0343	COG4214	carbohydrate transport
D11S_0344	COG1129	ABC transporter
D11S_0345	COG4213	ABC transporter substrate-binding protein
D11S_0346	COG2115	Belongs to the xylose isomerase family
D11S_0347	COG1070	Carbohydrate kinase
D11S_0351	COG2801	Transposase and inactivated derivatives
D11S_0352	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D11S_0353	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D11S_0354	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_0355	COG3719	Belongs to the RNase T2 family
D11S_0357	COG0191	fructose-bisphosphate aldolase activity
D11S_0359	COG3307	-O-antigen
D11S_0360	COG2267	carboxylic ester hydrolase activity
D11S_0361	COG0561	phosphatase activity
D11S_0363	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D11S_0364	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D11S_0365	COG2177	Part of the ABC transporter FtsEX involved in
D11S_0366	COG2884	Cell division ATP-binding protein ftsE
D11S_0368	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D11S_0374	COG1238	metal cluster binding
D11S_0376	COG1388	LysM domain
D11S_0376	COG4942	peptidase
D11S_0378	COG0463	Glycosyl transferase, family 2
D11S_0379	COG1519	Transferase
D11S_0382	COG0859	PFAM glycosyl transferase family 9
D11S_0383	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D11S_0384	COG4977	sequence-specific DNA binding
D11S_0384	COG1917	Cupin 2, conserved barrel domain protein
D11S_0385	COG1132	(ABC) transporter
D11S_0393	COG0758	DNA mediated transformation
D11S_0394	COG0584	glycerophosphoryl diester phosphodiesterase
D11S_0395	COG2271	Major facilitator Superfamily
D11S_0398	COG0557	exoribonuclease II activity
D11S_0399	COG1077	Cell shape determining protein MreB Mrl
D11S_0400	COG1792	Involved in formation and maintenance of cell shape
D11S_0401	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D11S_0408	COG0006	proline dipeptidase activity
D11S_0411	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D11S_0415	COG1368	sulfuric ester hydrolase activity
D11S_0416	COG0778	Nitroreductase
D11S_0418	COG0762	integral membrane protein
D11S_0420	COG0500	methyltransferase
D11S_0422	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D11S_0423	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_0424	COG1309	transcriptional regulator
D11S_0425	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_0426	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D11S_0429	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_0432	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_0436	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D11S_0440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D11S_0442	COG1309	transcriptional regulator
D11S_0445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D11S_0446	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D11S_0447	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D11S_0448	COG4972	Pilus assembly protein
D11S_0452	COG4796	Type ii and iii secretion system protein
D11S_0455	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D11S_0457	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D11S_0458	COG0789	Transcriptional regulator
D11S_0459	COG4701	Protein of unknown function (DUF721)
D11S_0462	COG0494	nUDIX hydrolase
D11S_0463	COG1466	dna polymerase III delta subunit
D11S_0464	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D11S_0469	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D11S_0470	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D11S_0471	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D11S_0472	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D11S_0473	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D11S_0477	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D11S_0479	COG4221	oxidoreductase activity
D11S_0480	COG0789	Transcriptional regulator
D11S_0481	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D11S_0482	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D11S_0484	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D11S_0485	COG4137	Cytochrome C assembly protein
D11S_0486	COG4536	flavin adenine dinucleotide binding
D11S_0487	COG0811	peptide transport
D11S_0488	COG0848	biopolymer transport protein
D11S_0493	COG0243	molybdopterin cofactor binding
D11S_0494	COG0437	4 iron, 4 sulfur cluster binding
D11S_0495	COG3302	dmso reductase anchor subunit
D11S_0496	COG3381	protein complex oligomerization
D11S_0497	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_0497	COG2221	Nitrite and sulphite reductase 4Fe-4S
D11S_0499	COG4545	Glutaredoxin-related protein
D11S_0504	COG0805	protein transport
D11S_0505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D11S_0506	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D11S_0507	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D11S_0508	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D11S_0509	COG1011	Hydrolase
D11S_0510	COG0494	nUDIX hydrolase
D11S_0511	COG1917	Cupin 2, conserved barrel domain protein
D11S_0511	COG4977	sequence-specific DNA binding
D11S_0512	COG3059	membrane
D11S_0513	COG1297	OPT oligopeptide transporter protein
D11S_0515	COG1218	3'(2'),5'-bisphosphate nucleotidase
D11S_0516	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D11S_0517	COG0363	glucosamine-6-phosphate deaminase activity
D11S_0520	COG1794	racemase activity, acting on amino acids and derivatives
D11S_0521	COG4545	Glutaredoxin-related protein
D11S_0525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_0526	COG1028	Short-chain dehydrogenase reductase Sdr
D11S_0528	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_0539	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D11S_0544	COG1011	Hydrolase
D11S_0546	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D11S_0547	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D11S_0552	COG1596	polysaccharide export
D11S_0552	COG1555	photosystem II stabilization
D11S_0553	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D11S_0554	COG0561	phosphatase activity
D11S_0555	COG1040	competence protein
D11S_0558	COG1114	Component of the transport system for branched-chain amino acids
D11S_0561	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D11S_0562	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D11S_0564	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D11S_0567	COG0201	protein transport
D11S_0571	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D11S_0574	COG0814	amino acid
D11S_0575	COG2129	metallophosphoesterase
D11S_0576	COG3172	ATPase kinase involved in NAD metabolism
D11S_0581	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D11S_0582	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D11S_0596	COG0859	PFAM glycosyl transferase family 9
D11S_0597	COG1027	Aspartate ammonia-lyase
D11S_0599	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D11S_0600	COG0459	protein refolding
D11S_0604	COG2801	Transposase and inactivated derivatives
D11S_0607	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D11S_0608	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D11S_0609	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D11S_0610	COG1381	Involved in DNA repair and RecF pathway recombination
D11S_0611	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D11S_0614	COG0354	folic acid binding
D11S_0615	COG1561	YicC-like family, N-terminal region
D11S_0617	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D11S_0620	COG3842	ATPase activity
D11S_0621	COG1178	ABC-type Fe3 transport system permease component
D11S_0622	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_0623	COG3171	Protein conserved in bacteria
D11S_0625	COG1194	a g-specific adenine glycosylase
D11S_0626	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D11S_0631	COG3056	Lipoprotein
D11S_0632	COG0271	Belongs to the BolA IbaG family
D11S_0637	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_0638	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_0639	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D11S_0640	COG2871	sodium ion transport
D11S_0642	COG1477	protein flavinylation
D11S_0643	COG2991	Protein conserved in bacteria
D11S_0646	COG0148	phosphopyruvate hydratase activity
D11S_0649	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D11S_0651	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D11S_0652	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D11S_0653	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D11S_0654	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D11S_0657	COG3956	TIGRFAM MazG family protein
D11S_0658	COG0402	S-adenosylhomocysteine deaminase activity
D11S_0659	COG3083	sulfuric ester hydrolase activity
D11S_0660	COG3082	Protein of unknown function (DUF1414)
D11S_0662	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D11S_0663	COG0745	RESPONSE REGULATOR receiver
D11S_0664	COG2205	protein histidine kinase activity
D11S_0665	COG0786	glutamate:sodium symporter activity
D11S_0666	COG1490	D-aminoacyl-tRNA deacylase activity
D11S_0668	COG3012	SEC-C Motif Domain Protein
D11S_0669	COG2258	MOSC domain
D11S_0670	COG0433	COG0433 Predicted ATPase
D11S_0673	COG0656	L-ascorbic acid biosynthetic process
D11S_0674	COG0667	Aldo Keto reductase
D11S_0675	COG2272	Belongs to the type-B carboxylesterase lipase family
D11S_0681	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D11S_0682	COG1349	DNA-binding transcription factor activity
D11S_0684	COG3068	Protein conserved in bacteria
D11S_0685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D11S_0690	COG0248	Ppx GppA phosphatase
D11S_0691	COG2911	Protein conserved in bacteria
D11S_0692	COG0729	surface antigen
D11S_0693	COG2197	response regulator
D11S_0695	COG0181	hydroxymethylbilane synthase activity
D11S_0697	COG2959	enzyme of heme biosynthesis
D11S_0698	COG3071	HemY protein
D11S_0699	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D11S_0701	COG1595	DNA-templated transcription, initiation
D11S_0703	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D11S_0709	COG0583	DNA-binding transcription factor activity
D11S_0710	COG2183	response to ionizing radiation
D11S_0712	COG1172	Belongs to the binding-protein-dependent transport system permease family
D11S_0713	COG1129	ABC transporter
D11S_0722	COG1072	(Pantothenic acid kinase))
D11S_0723	COG0187	DNA topoisomerase II activity
D11S_0724	COG0514	ATP-dependent DNA helicase (RecQ)
D11S_0727	COG0019	diaminopimelate decarboxylase activity
D11S_0728	COG3477	response to acidic pH
D11S_0729	COG2818	Glycosylase
D11S_0730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D11S_0733	COG2195	Cleaves the N-terminal amino acid of tripeptides
D11S_0734	COG0300	oxidoreductase activity
D11S_0735	COG1763	Mo-molybdopterin cofactor biosynthetic process
D11S_0736	COG3086	response to oxidative stress
D11S_0737	COG3026	antisigma factor binding
D11S_0738	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D11S_0739	COG1595	DNA-templated transcription, initiation
D11S_0742	COG0442	prolyl-tRNA aminoacylation
D11S_0743	COG1921	L-seryl-tRNASec selenium transferase activity
D11S_0744	COG3276	selenocysteine insertion sequence binding
D11S_0749	COG0733	neurotransmitter:sodium symporter activity
D11S_0761	COG4964	Belongs to the GSP D family
D11S_0766	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D11S_0768	COG1444	tRNA N-acetyltransferase activity
D11S_0770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D11S_0772	COG1126	abc transporter atp-binding protein
D11S_0773	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D11S_0774	COG4215	(ABC) transporter
D11S_0775	COG4160	amino acid transport
D11S_0776	COG1966	Carbon starvation protein
D11S_0779	COG3116	cell division
D11S_0780	COG0768	penicillin binding
D11S_0782	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D11S_0784	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D11S_0786	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D11S_0789	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D11S_0790	COG0849	cell division
D11S_0791	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D11S_0795	COG0326	Molecular chaperone. Has ATPase activity
D11S_0796	COG1393	Belongs to the ArsC family
D11S_0798	COG1876	peptidase activity
D11S_0799	COG0494	nUDIX hydrolase
D11S_0800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D11S_0809	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D11S_0811	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D11S_0812	COG1053	succinate dehydrogenase
D11S_0815	COG1120	ATPase activity
D11S_0816	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_0817	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_0818	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D11S_0819	COG1408	metallophosphoesterase
D11S_0821	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D11S_0822	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D11S_0826	COG0582	viral genome integration into host DNA
D11S_0829	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D11S_0831	COG0741	lytic transglycosylase activity
D11S_0832	COG2350	Protein conserved in bacteria
D11S_0833	COG1607	acyl-coa hydrolase
D11S_0834	COG2917	probably involved in intracellular septation
D11S_0836	COG3047	cAMP biosynthetic process
D11S_0838	COG0497	DNA recombination
D11S_0841	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D11S_0843	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D11S_0843	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D11S_0844	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D11S_0846	COG0784	Response regulator, receiver
D11S_0846	COG5002	protein histidine kinase activity
D11S_0846	COG2198	Histidine kinase
D11S_0847	COG4211	Belongs to the binding-protein-dependent transport system permease family
D11S_0849	COG1879	ABC-type sugar transport system periplasmic component
D11S_0850	COG1609	Transcriptional regulator
D11S_0851	COG1085	galactose-1-phosphate uridylyltransferase
D11S_0852	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D11S_0853	COG2017	converts alpha-aldose to the beta-anomer
D11S_0856	COG0471	metal ion transport
D11S_0857	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D11S_0857	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D11S_0858	COG3051	citrate lyase alpha subunit
D11S_0859	COG2301	Belongs to the HpcH HpaI aldolase family
D11S_0861	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D11S_0863	COG4535	Mg2 and Co2 transporter CorC
D11S_0868	COG0105	UTP biosynthetic process
D11S_0871	COG0489	protein tyrosine kinase activity
D11S_0872	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D11S_0872	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D11S_0873	COG2975	iron-sulfur cluster assembly
D11S_0874	COG0633	Ferredoxin
D11S_0875	COG0443	Heat shock 70 kDa protein
D11S_0878	COG0822	iron-sulfur transferase activity
D11S_0880	COG1959	2 iron, 2 sulfur cluster binding
D11S_0881	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D11S_0887	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_0897	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D11S_0898	COG1530	ribonuclease E activity
D11S_0899	COG2999	glutathione oxidoreductase activity
D11S_0900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D11S_0909	COG3021	interspecies interaction between organisms
D11S_0916	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D11S_0917	COG0626	cystathionine gamma-synthase activity
D11S_0920	COG2337	Toxic component of a toxin-antitoxin (TA) module
D11S_0921	COG0484	heat shock protein binding
D11S_0922	COG0443	Heat shock 70 kDa protein
D11S_0923	COG5339	Protein conserved in bacteria
D11S_0925	COG3102	Protein conserved in bacteria
D11S_0926	COG3133	Outer membrane lipoprotein
D11S_0927	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D11S_0928	COG2890	protein-(glutamine-N5) methyltransferase activity
D11S_0930	COG0791	NLP P60 protein
D11S_0931	COG3100	YcgL domain-containing protein
D11S_0934	COG2062	phosphohistidine phosphatase, SixA
D11S_0936	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D11S_0937	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D11S_0939	COG2932	Transcriptional regulator
D11S_0941	COG0516	GMP reductase activity
D11S_0941	COG0517	IMP dehydrogenase activity
D11S_0942	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D11S_0942	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D11S_0949	COG4172	Belongs to the ABC transporter superfamily
D11S_0950	COG4172	Belongs to the ABC transporter superfamily
D11S_0951	COG4171	peptide transport system, permease
D11S_0952	COG4168	peptide transport system, permease
D11S_0953	COG4166	transmembrane transport
D11S_0954	COG3106	COG3106 Predicted ATPase
D11S_0956	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D11S_0959	COG1923	regulation of RNA biosynthetic process
D11S_0961	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D11S_0962	COG0860	N-Acetylmuramoyl-L-alanine amidase
D11S_0962	COG1388	LysM domain
D11S_0963	COG0802	atpase or kinase
D11S_0967	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D11S_0969	COG2194	sulfuric ester hydrolase activity
D11S_0973	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_0974	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D11S_0975	COG2190	(PTS) system
D11S_0976	COG0339	signal peptide processing
D11S_0977	COG2832	Protein of unknown function (DUF454)
D11S_0978	COG4166	transmembrane transport
D11S_0979	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D11S_0981	COG0512	Glutamine amidotransferase of anthranilate synthase
D11S_0982	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D11S_0983	COG4591	ABC-type transport system involved in lipoprotein release permease component
D11S_0985	COG4591	ABC-type transport system involved in lipoprotein release permease component
D11S_0986	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D11S_0988	COG0305	Participates in initiation and elongation during chromosome replication
D11S_0990	COG0166	Belongs to the GPI family
D11S_0991	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D11S_0993	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D11S_0994	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D11S_0995	COG1280	lysine exporter protein (LysE YggA)
D11S_0998	COG0633	Ferredoxin
D11S_1000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_1001	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_1004	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_1006	COG3842	ATPase activity
D11S_1008	COG0366	Alpha amylase catalytic
D11S_1009	COG3833	ABC-type maltose transport systems, permease component
D11S_1012	COG2182	Extracellular solute-binding protein
D11S_1013	COG3842	ATPase activity
D11S_1014	COG4580	involved in the transport of maltose and maltodextrins
D11S_1017	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D11S_1018	COG0303	'Molybdopterin
D11S_1020	COG2027	D-alanyl-D-alanine carboxypeptidase
D11S_1021	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D11S_1022	COG1534	Rna-binding protein
D11S_1023	COG3657	addiction module killer protein
D11S_1024	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D11S_1025	COG0307	riboflavin synthase, alpha
D11S_1027	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D11S_1028	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D11S_1029	COG3955	Domain of unknown function (DUF1919)
D11S_1044	COG2855	membrane
D11S_1045	COG4953	penicillin-binding protein 1C
D11S_1046	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D11S_1051	COG3623	hexulose-6-phosphate isomerase
D11S_1052	COG0235	Class ii aldolase
D11S_1053	COG0814	amino acid
D11S_1056	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D11S_1057	COG0778	Nitroreductase
D11S_1060	COG2268	Band 7 protein
D11S_1061	COG0114	fumarate hydratase activity
D11S_1062	COG2927	DNA polymerase III (CHI subunit)
D11S_1071	COG2814	Major facilitator Superfamily
D11S_1074	COG0783	Belongs to the Dps family
D11S_1076	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D11S_1077	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D11S_1078	COG0602	queuosine metabolic process
D11S_1079	COG0720	synthase
D11S_1080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D11S_1083	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_1084	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D11S_1085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D11S_1086	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D11S_1087	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D11S_1088	COG0310	cobalt ion transport
D11S_1089	COG0310	cobalt ion transport
D11S_1090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D11S_1091	COG1122	ATPase activity
D11S_1093	COG0409	Hydrogenase expression formation protein
D11S_1094	COG0309	Hydrogenase expression formation protein (HypE)
D11S_1096	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D11S_1097	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D11S_1098	COG0795	lipopolysaccharide-transporting ATPase activity
D11S_1099	COG0795	lipopolysaccharide-transporting ATPase activity
D11S_1100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D11S_1101	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D11S_1102	COG4149	molybdate abc transporter
D11S_1103	COG0725	ABC transporter, periplasmic molybdate-binding protein
D11S_1104	COG2005	Transcriptional regulator
D11S_1105	COG0471	metal ion transport
D11S_1107	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D11S_1108	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D11S_1108	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D11S_1109	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D11S_1111	COG0583	DNA-binding transcription factor activity
D11S_1112	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D11S_1114	COG0039	L-malate dehydrogenase activity
D11S_1115	COG1438	arginine binding
D11S_1116	COG1090	epimerase
D11S_1117	COG4657	Part of a membrane complex involved in electron transport
D11S_1123	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D11S_1124	COG0733	neurotransmitter:sodium symporter activity
D11S_1125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_1127	COG0739	heme binding
D11S_1128	COG4604	ABC transporter, ATP-binding protein
D11S_1129	COG4605	iron ion homeostasis
D11S_1130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D11S_1131	COG4607	ABC-type enterochelin transport system periplasmic component
D11S_1132	COG0737	Belongs to the 5'-nucleotidase family
D11S_1135	COG3111	PFAM Bacterial OB fold (BOF) protein
D11S_1136	COG0745	RESPONSE REGULATOR receiver
D11S_1137	COG0642	Histidine kinase
D11S_1138	COG0405	Gamma-glutamyltransferase
D11S_1141	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D11S_1143	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D11S_1144	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D11S_1150	COG1518	maintenance of DNA repeat elements
D11S_1152	COG0351	phosphomethylpyrimidine kinase
D11S_1153	COG4143	(ABC) transporter
D11S_1154	COG1178	ABC-type Fe3 transport system permease component
D11S_1155	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D11S_1157	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D11S_1159	COG3105	Protein conserved in bacteria
D11S_1160	COG1944	ATP diphosphatase activity
D11S_1162	COG3422	double-strand break repair
D11S_1165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D11S_1167	COG1940	carbohydrate kinase activity
D11S_1167	COG1846	Transcriptional regulator
D11S_1172	COG0563	adenylate kinase activity
D11S_1173	COG2814	Major facilitator Superfamily
D11S_1174	COG0375	protein maturation
D11S_1175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D11S_1176	COG3152	Membrane
D11S_1181	COG0825	malonyl-CoA metabolic process
D11S_1187	COG1598	PFAM Uncharacterised protein family UPF0150
D11S_1190	COG3617	BRO family, N-terminal domain
D11S_1194	COG3041	Addiction module toxin RelE StbE family
D11S_1195	COG3077	Addiction module antitoxin, RelB DinJ family
D11S_1197	COG3069	C4-dicarboxylate transmembrane transporter activity
D11S_1200	COG0195	Participates in both transcription termination and antitermination
D11S_1202	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D11S_1206	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D11S_1208	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D11S_1209	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D11S_1212	COG3177	Filamentation induced by cAMP protein fic
D11S_1215	COG1175	transmembrane transport
D11S_1216	COG0395	ABC-type sugar transport system, permease component
D11S_1218	COG0322	excinuclease ABC activity
D11S_1220	COG2835	tetraacyldisaccharide 4'-kinase activity
D11S_1221	COG1663	tetraacyldisaccharide 4'-kinase activity
D11S_1222	COG1132	(ABC) transporter
D11S_1223	COG0658	competence protein
D11S_1223	COG2333	competence protein COMEC
D11S_1224	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D11S_1227	COG0280	phosphate acetyltransferase
D11S_1227	COG0857	belongs to the CobB CobQ family
D11S_1228	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D11S_1229	COG3092	negative regulation of chromosome organization
D11S_1230	COG1286	toxin biosynthetic process
D11S_1232	COG1640	4-alpha-glucanotransferase
D11S_1233	COG0058	SHG alpha-glucan phosphorylase activity
D11S_1234	COG2909	trisaccharide binding
D11S_1236	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D11S_1237	COG0508	dehydrogenase complex catalyzes the overall conversion of
D11S_1238	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D11S_1240	COG0778	Nitroreductase
D11S_1241	COG0616	signal peptide processing
D11S_1242	COG1605	Chorismate mutase
D11S_1242	COG0287	Prephenate dehydrogenase
D11S_1243	COG0009	L-threonylcarbamoyladenylate synthase
D11S_1245	COG0583	DNA-binding transcription factor activity
D11S_1247	COG3099	Belongs to the UPF0263 family
D11S_1250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D11S_1251	COG2949	membrane
D11S_1252	COG1609	Transcriptional regulator
D11S_1255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_1256	COG0785	Cytochrome C biogenesis protein
D11S_1257	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D11S_1257	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D11S_1258	COG0288	reversible hydration of carbon dioxide
D11S_1259	COG2823	Periplasmic or secreted lipoprotein
D11S_1260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D11S_1261	COG0792	nuclease activity
D11S_1263	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D11S_1265	COG1252	NADH dehydrogenase
D11S_1267	COG0616	signal peptide processing
D11S_1268	COG2885	chlorophyll binding
D11S_1268	COG3047	cAMP biosynthetic process
D11S_1277	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D11S_1279	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D11S_1285	COG1349	DNA-binding transcription factor activity
D11S_1287	COG0142	geranyltranstransferase activity
D11S_1290	COG0285	dihydrofolate synthase activity
D11S_1291	COG0406	alpha-ribazole phosphatase activity
D11S_1292	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D11S_1293	COG2431	L-lysine efflux transmembrane transporter activity
D11S_1297	COG2824	Alkylphosphonate utilization operon protein PhnA
D11S_1303	COG1538	Outer membrane efflux protein
D11S_1304	COG0577	efflux transmembrane transporter activity
D11S_1304	COG1136	(ABC) transporter
D11S_1305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_1310	COG1523	belongs to the glycosyl hydrolase 13 family
D11S_1313	COG0058	SHG alpha-glucan phosphorylase activity
D11S_1315	COG0586	Pfam SNARE associated Golgi protein
D11S_1316	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D11S_1318	COG1686	Belongs to the peptidase S11 family
D11S_1319	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D11S_1322	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D11S_1323	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D11S_1324	COG0697	spore germination
D11S_1325	COG2925	Exonuclease
D11S_1330	COG1528	Iron-storage protein
D11S_1331	COG1528	Iron-storage protein
D11S_1333	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D11S_1334	COG0589	response to stress
D11S_1335	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D11S_1338	COG0167	dihydroorotate dehydrogenase activity
D11S_1339	COG0308	aminopeptidase N
D11S_1340	COG1448	Aminotransferase
D11S_1343	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_1346	COG0842	Transport permease protein
D11S_1349	COG1120	ATPase activity
D11S_1351	COG3585	molybdate ion transport
D11S_1355	COG1120	ATPase activity
D11S_1359	COG4774	siderophore transport
D11S_1363	COG0791	NLP P60 protein
D11S_1366	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D11S_1368	COG0517	IMP dehydrogenase activity
D11S_1368	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D11S_1369	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D11S_1370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D11S_1372	COG1942	4-Oxalocrotonate Tautomerase
D11S_1374	COG0134	indole-3-glycerol-phosphate synthase activity
D11S_1374	COG0135	phosphoribosylanthranilate isomerase activity
D11S_1376	COG0298	carbon dioxide binding
D11S_1379	COG3630	sodium ion export across plasma membrane
D11S_1380	COG5016	pyruvate
D11S_1380	COG0511	ligase activity, forming carbon-carbon bonds
D11S_1383	COG1629	transport
D11S_1383	COG4771	TonB-dependent receptor
D11S_1385	COG4221	oxidoreductase activity
D11S_1386	COG0133	tryptophan synthase activity
D11S_1388	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D11S_1390	COG0469	pyruvate kinase activity
D11S_1393	COG1879	ABC-type sugar transport system periplasmic component
D11S_1397	COG2390	Transcriptional regulator
D11S_1398	COG1070	Carbohydrate kinase
D11S_1399	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D11S_1400	COG1940	carbohydrate kinase activity
D11S_1402	COG2969	positive regulation of protein catabolic process
D11S_1404	COG0314	molybdopterin synthase activity
D11S_1405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D11S_1407	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D11S_1412	COG3005	denitrification pathway
D11S_1413	COG0243	molybdopterin cofactor binding
D11S_1414	COG2315	Protein conserved in bacteria
D11S_1415	COG0471	metal ion transport
D11S_1418	COG2026	Addiction module toxin, RelE StbE family
D11S_1419	COG0101	tRNA pseudouridine synthase activity
D11S_1424	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D11S_1425	COG1074	ATP-dependent DNA helicase activity
D11S_1426	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D11S_1428	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D11S_1429	COG1067	ATP-dependent peptidase activity
D11S_1431	COG1278	Cold shock
D11S_1434	COG3098	single-species biofilm formation
D11S_1435	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D11S_1436	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D11S_1436	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D11S_1439	COG1840	ABC-type Fe3 transport system, periplasmic component
D11S_1441	COG3842	ATPase activity
D11S_1443	COG3842	ATPase activity
D11S_1446	COG0788	formyltetrahydrofolate deformylase activity
D11S_1447	COG2916	Histone family protein nucleoid-structuring protein H-NS
D11S_1448	COG1757	Na H antiporter
D11S_1456	COG3161	chorismate lyase activity
D11S_1458	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D11S_1459	COG1758	RNA polymerase activity
D11S_1462	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D11S_1464	COG2867	negative regulation of translational initiation
D11S_1466	COG2850	peptidyl-arginine hydroxylation
D11S_1469	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D11S_1470	COG1137	ATPase activity
D11S_1471	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D11S_1472	COG3117	lipopolysaccharide transmembrane transporter activity
D11S_1473	COG1127	ABC transporter
D11S_1474	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D11S_1475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D11S_1476	COG2854	intermembrane phospholipid transfer
D11S_1477	COG3113	response to antibiotic
D11S_1478	COG5007	Belongs to the BolA IbaG family
D11S_1480	COG3691	Protein conserved in bacteria
D11S_1482	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D11S_1484	COG0861	Integral membrane protein TerC family
D11S_1489	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D11S_1490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D11S_1493	COG1125	glycine betaine transport
D11S_1493	COG0517	IMP dehydrogenase activity
D11S_1494	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D11S_1497	COG0527	aspartate kinase activity
D11S_1497	COG0460	homoserine dehydrogenase
D11S_1500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D11S_1501	COG2091	lysine biosynthetic process via aminoadipic acid
D11S_1502	COG0330	HflC and HflK could
D11S_1503	COG0330	HflC and HflK could
D11S_1505	COG1555	photosystem II stabilization
D11S_1506	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D11S_1508	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D11S_1509	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D11S_1510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D11S_1515	COG2186	Transcriptional regulator
D11S_1520	COG0659	secondary active sulfate transmembrane transporter activity
D11S_1522	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D11S_1523	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D11S_1525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D11S_1527	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D11S_1531	COG3115	cell septum assembly
D11S_1533	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D11S_1536	COG1573	uracil-dna glycosylase
D11S_1537	COG0012	GTP binding
D11S_1538	COG0193	aminoacyl-tRNA hydrolase activity
D11S_1550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D11S_1551	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D11S_1553	COG0024	Methionine aminopeptidase
D11S_1554	COG0316	Belongs to the HesB IscA family
D11S_1556	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D11S_1557	COG0672	)-iron permease
D11S_1560	COG0577	efflux transmembrane transporter activity
D11S_1562	COG1136	(ABC) transporter
D11S_1562	COG0577	efflux transmembrane transporter activity
D11S_1563	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_1565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D11S_1567	COG3385	transposase activity
D11S_1569	COG1643	Atp-dependent helicase
D11S_1570	COG2363	Small membrane protein
D11S_1574	COG0247	lactate metabolic process
D11S_1574	COG0277	FAD linked oxidase domain protein
D11S_1577	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D11S_1578	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D11S_1579	COG0363	glucosamine-6-phosphate deaminase activity
D11S_1580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D11S_1581	COG1737	Transcriptional regulator
D11S_1583	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D11S_1584	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D11S_1586	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D11S_1587	COG2190	(PTS) system
D11S_1587	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D11S_1587	COG1263	PTS System
D11S_1591	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D11S_1592	COG3683	transport system, periplasmic component
D11S_1594	COG0488	(ABC) transporter
D11S_1596	COG0187	DNA topoisomerase II activity
D11S_1598	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D11S_1599	COG0625	glutathione transferase activity
D11S_1600	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D11S_1602	COG0251	oxidation-reduction process
D11S_1605	COG0463	Glycosyl transferase, family 2
D11S_1610	COG1560	Kdo2-lipid A biosynthetic process
D11S_1611	COG0730	response to heat
D11S_1612	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D11S_1613	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D11S_1614	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D11S_1614	COG3264	Mechanosensitive ion channel
D11S_1615	COG0318	PFAM AMP-dependent synthetase and ligase
D11S_1616	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D11S_1617	COG0596	Alpha beta hydrolase
D11S_1618	COG0716	FMN binding
D11S_1619	COG0735	belongs to the Fur family
D11S_1620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D11S_1621	COG3094	Invasion gene expression up-regulator, SirB
D11S_1622	COG0023	Translation Initiation Factor
D11S_1624	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D11S_1625	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D11S_1626	COG0776	regulation of translation
D11S_1627	COG0539	negative regulation of cytoplasmic translation
D11S_1629	COG2990	Protein conserved in bacteria
D11S_1630	COG4771	TonB-dependent receptor
D11S_1631	COG0612	Peptidase, M16
D11S_1632	COG1687	branched-chain amino acid
D11S_1633	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D11S_1635	COG0583	DNA-binding transcription factor activity
D11S_1640	COG2920	part of a sulfur-relay system
D11S_1642	COG1121	(ABC) transporter
D11S_1643	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_1644	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D11S_1647	COG1803	Methylglyoxal synthase
D11S_1648	COG3304	Inner membrane component domain
D11S_1649	COG1289	transmembrane transporter activity
D11S_1653	COG3958	Transketolase
D11S_1654	COG3959	Transketolase, thiamine diphosphate binding domain
D11S_1661	COG1346	cytolysis
D11S_1664	COG1525	nuclease
D11S_1665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D11S_1666	COG2166	iron-sulfur cluster assembly
D11S_1667	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D11S_1667	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D11S_1668	COG1560	Kdo2-lipid A biosynthetic process
D11S_1669	COG3381	protein complex oligomerization
D11S_1670	COG2249	NAD(P)H dehydrogenase (quinone) activity
D11S_1672	COG0330	HflC and HflK could
D11S_1676	COG1858	cytochrome C peroxidase
D11S_1677	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D11S_1678	COG0318	PFAM AMP-dependent synthetase and ligase
D11S_1679	COG3065	identical protein binding
D11S_1680	COG1214	PFAM Peptidase M22, glycoprotease
D11S_1681	COG1199	ATP-dependent helicase activity
D11S_1682	COG0676	glucose-6-phosphate 1-epimerase activity
D11S_1683	COG3118	belongs to the thioredoxin family
D11S_1684	COG0492	ferredoxin-NADP+ reductase activity
D11S_1685	COG4988	ABC transporter
D11S_1686	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D11S_1688	COG0515	serine threonine protein kinase
D11S_1691	COG1940	carbohydrate kinase activity
D11S_1692	COG0671	phosphoesterase, PA-phosphatase related
D11S_1693	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D11S_1697	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D11S_1698	COG0708	Exodeoxyribonuclease III
D11S_1702	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D11S_1711	COG2951	lytic endotransglycosylase activity
D11S_1712	COG1216	Glycosyl transferase, family 2
D11S_1713	COG1216	Glycosyl transferase, family 2
D11S_1715	COG3306	glycosyltransferase involved in LPS biosynthesis
D11S_1717	COG5039	Polysaccharide pyruvyl transferase
D11S_1718	COG2161	toxin-antitoxin pair type II binding
D11S_1719	COG4115	mRNA cleavage
D11S_1720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D11S_1722	COG1793	dna ligase
D11S_1723	COG0210	DNA helicase
D11S_1724	COG2610	gluconate transmembrane transporter activity
D11S_1725	COG3265	gluconokinase activity
D11S_1727	COG1609	Transcriptional regulator
D11S_1732	COG0437	4 iron, 4 sulfur cluster binding
D11S_1733	COG2864	formate dehydrogenase
D11S_1735	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D11S_1736	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D11S_1737	COG0651	ATP synthesis coupled electron transport
D11S_1738	COG0651	ATP synthesis coupled electron transport
D11S_1739	COG0650	Formate hydrogenlyase subunit 4
D11S_1740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D11S_1741	COG4237	Hydrogenase 4 membrane
D11S_1742	COG0651	ATP synthesis coupled electron transport
D11S_1743	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D11S_1743	COG3261	NADH dehydrogenase
D11S_1744	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D11S_1745	COG3260	NADH ubiquinone oxidoreductase 20
D11S_1747	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D11S_1748	COG3383	formate dehydrogenase (NAD+) activity
D11S_1749	COG3383	formate dehydrogenase (NAD+) activity
D11S_1750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D11S_1753	COG0508	dehydrogenase complex catalyzes the overall conversion of
D11S_1754	COG0567	Dehydrogenase, E1 component
D11S_1756	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D11S_1758	COG2989	Protein conserved in bacteria
D11S_1759	COG0793	Belongs to the peptidase S41A family
D11S_1761	COG2995	paraquat-inducible protein a
D11S_1762	COG3008	intermembrane lipid transfer
D11S_1764	COG3842	ATPase activity
D11S_1765	COG1176	ABC-type spermidine putrescine transport system, permease component I
D11S_1766	COG1177	transmembrane transport
D11S_1767	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D11S_1771	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D11S_1772	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D11S_1775	COG1522	sequence-specific DNA binding
D11S_1776	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D11S_1777	COG3025	triphosphatase activity
D11S_1778	COG1392	Phosphate transport regulator
D11S_1779	COG0306	phosphate transporter
D11S_1780	COG4991	sh3 domain protein
D11S_1781	COG0617	tRNA 3'-terminal CCA addition
D11S_1782	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D11S_1783	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D11S_1787	COG1620	l-lactate permease
D11S_1793	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D11S_1795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D11S_1799	COG2026	Addiction module toxin, RelE StbE family
D11S_1804	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D11S_1806	COG1862	Preprotein translocase
D11S_1807	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D11S_1808	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D11S_1811	COG1012	belongs to the aldehyde dehydrogenase family
D11S_1811	COG1454	alcohol dehydrogenase
D11S_1812	COG1172	Belongs to the binding-protein-dependent transport system permease family
D11S_1813	COG0673	inositol 2-dehydrogenase activity
D11S_1814	COG3722	fumarate hydratase activity
D11S_1815	COG0246	Mannitol dehydrogenase
D11S_1817	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D11S_1818	COG2274	protein secretion by the type I secretion system
D11S_1819	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D11S_1820	COG2994	toxin metabolic process
D11S_1821	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D11S_1825	COG2813	Specifically methylates the guanine in position
D11S_1826	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D11S_1827	COG0456	acetyltransferase
D11S_1828	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D11S_1832	COG2165	general secretion pathway protein
D11S_1838	COG3064	Membrane
D11S_1839	COG0848	biopolymer transport protein
D11S_1840	COG0811	peptide transport
D11S_1841	COG0824	Thioesterase
D11S_1843	COG1294	oxidase, subunit
D11S_1844	COG1271	oxidase subunit
D11S_1849	COG0641	radical SAM
D11S_1850	COG0217	transcriptional regulatory protein
D11S_1851	COG0494	nUDIX hydrolase
D11S_1854	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D11S_1855	COG1755	Isoprenylcysteine carboxyl methyltransferase
D11S_1863	COG2271	Major facilitator Superfamily
D11S_1865	COG0346	lactoylglutathione lyase activity
D11S_1866	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D11S_1867	COG2056	Na+-H+ antiporter family
D11S_1872	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D11S_1873	COG0142	geranyltranstransferase activity
D11S_1876	COG0697	spore germination
D11S_1877	COG0697	spore germination
D11S_1878	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D11S_1884	COG0601	transmembrane transport
D11S_1885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D11S_1886	COG0444	Belongs to the ABC transporter superfamily
D11S_1887	COG4608	Belongs to the ABC transporter superfamily
D11S_1888	COG0745	RESPONSE REGULATOR receiver
D11S_1890	COG1611	Belongs to the LOG family
D11S_1893	COG2259	Doxx family
D11S_1895	COG1530	ribonuclease E activity
D11S_1899	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D11S_1900	COG0626	cystathionine gamma-synthase activity
D11S_1908	COG2860	membrane
D11S_1912	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D11S_1914	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D11S_1915	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D11S_1916	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D11S_1917	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D11S_1919	COG0560	Phosphoserine phosphatase
D11S_1923	COG0728	peptidoglycan biosynthetic process
D11S_1924	COG0196	riboflavin kinase activity
D11S_1927	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D11S_1929	COG0544	peptidyl-prolyl cis-trans isomerase activity
D11S_1930	COG4974	Belongs to the 'phage' integrase family
D11S_1931	COG2814	Major facilitator Superfamily
D11S_1932	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D11S_1933	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D11S_1936	COG3266	domain, Protein
D11S_1936	COG3061	Opacity-associated protein A
D11S_1937	COG1509	lysine 2,3-aminomutase activity
D11S_1940	COG3033	Beta-eliminating lyase
D11S_1941	COG0814	amino acid
D11S_1942	COG2964	Protein conserved in bacteria
D11S_1943	COG5413	integral membrane protein
D11S_1945	COG0204	Acyl-transferase
D11S_1947	COG0697	spore germination
D11S_1948	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D11S_1949	COG1882	Formate acetyltransferase
D11S_1950	COG2116	formate transmembrane transporter activity
D11S_1951	COG0537	adenosine 5'-monophosphoramidase activity
D11S_1959	COG3022	response to hydroperoxide
D11S_1960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D11S_1963	COG0681	Belongs to the peptidase S26 family
D11S_1970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D11S_1972	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D11S_1973	COG0592	DNA-directed DNA polymerase activity
D11S_1975	COG2226	methyltransferase
D11S_1980	COG0281	malic enzyme
D11S_1981	COG2081	HI0933 family
D11S_1982	COG4235	cytochrome complex assembly
D11S_1982	COG3088	subunit of a heme lyase
D11S_1983	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D11S_1984	COG1138	Cytochrome C-type biogenesis protein
D11S_1986	COG3301	Polysulphide reductase, NrfD
D11S_1987	COG0437	4 iron, 4 sulfur cluster binding
D11S_1988	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D11S_1995	COG1138	Cytochrome C-type biogenesis protein
D11S_1997	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_1998	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_1999	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D11S_2000	COG4133	protoheme IX ABC transporter activity
D11S_2005	COG0281	malic enzyme
D11S_2005	COG0280	phosphate acetyltransferase
D11S_2008	COG2321	neutral zinc metallopeptidase
D11S_2009	COG1652	LysM domain
D11S_2011	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D11S_2012	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D11S_2014	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D11S_2017	COG0436	Aminotransferase
D11S_2019	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D11S_2020	COG2267	carboxylic ester hydrolase activity
D11S_2023	COG3091	SprT-like family
D11S_2024	COG0814	amino acid
D11S_2025	COG1760	l-serine dehydratase
D11S_2026	COG0252	asparaginase activity
D11S_2028	COG3063	Type IV pilus biogenesis stability protein PilW
D11S_2029	COG1426	Protein conserved in bacteria
D11S_2032	COG2976	Protein conserved in bacteria
D11S_2034	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D11S_2036	COG2233	PERMEase
D11S_2037	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D11S_2038	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D11S_2039	COG2918	glutathione biosynthetic process
D11S_2039	COG1181	Belongs to the D-alanine--D-alanine ligase family
D11S_2041	COG2194	sulfuric ester hydrolase activity
D11S_2042	COG0740	serine-type endopeptidase activity
D11S_2046	COG3739	integral membrane protein
D11S_2047	COG2217	Heavy metal translocating P-type atpase
D11S_2048	COG2608	mercury ion transmembrane transporter activity
D11S_2049	COG0789	Transcriptional regulator
D11S_2050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D11S_2051	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D11S_2052	COG1720	tRNA m6t6A37 methyltransferase activity
D11S_2053	COG1575	Belongs to the MenA family. Type 1 subfamily
D11S_2057	COG3028	Belongs to the UPF0307 family
D11S_2058	COG0312	modulator of DNA gyrase
D11S_2059	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D11S_2060	COG1929	Belongs to the glycerate kinase type-1 family
D11S_2061	COG2610	gluconate transmembrane transporter activity
D11S_2062	COG3835	regulator
D11S_2064	COG0513	Belongs to the DEAD box helicase family
D11S_2065	COG4785	May be involved in cell division
D11S_2067	COG2731	YhcH YjgK YiaL family protein
D11S_2069	COG3023	N-Acetylmuramoyl-L-alanine amidase
D11S_2070	COG4969	Belongs to the N-Me-Phe pilin family
D11S_2071	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D11S_2072	COG1459	type II secretion system
D11S_2074	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D11S_2074	COG0237	dephospho-CoA kinase activity
D11S_2075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D11S_2077	COG1115	amino acid carrier protein
D11S_2078	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D11S_2083	COG2184	nucleotidyltransferase activity
D11S_2084	COG4145	pantothenate transmembrane transporter activity
D11S_2085	COG3924	membrane
D11S_2089	COG0439	Biotin carboxylase
D11S_2090	COG0511	ligase activity, forming carbon-carbon bonds
D11S_2096	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D11S_2098	COG0456	acetyltransferase
D11S_2099	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D11S_2101	COG3078	GTPase activator activity
D11S_2102	COG0590	tRNA wobble adenosine to inosine editing
D11S_2103	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D11S_2105	COG0730	response to heat
D11S_2107	COG1869	D-ribose catabolic process
D11S_2109	COG1172	Belongs to the binding-protein-dependent transport system permease family
D11S_2110	COG1879	ABC-type sugar transport system periplasmic component
D11S_2111	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D11S_2112	COG1278	Cold shock
D11S_2119	COG0165	Argininosuccinate lyase
D11S_2120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D11S_2121	COG0753	catalase activity
D11S_2123	COG0587	DNA-directed DNA polymerase activity
D11S_2125	COG1022	Amp-dependent synthetase and ligase
D11S_2128	COG1328	CTP reductase activity
D11S_2128	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D11S_2131	COG0602	queuosine metabolic process
D11S_2132	COG0084	hydrolase, TatD family'
D11S_2135	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D11S_2140	COG1686	Belongs to the peptidase S11 family
D11S_2141	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_2141	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D11S_2142	COG0772	Belongs to the SEDS family
D11S_2143	COG0768	penicillin binding
D11S_2145	COG0799	negative regulation of ribosome biogenesis
D11S_2146	COG0513	Belongs to the DEAD box helicase family
D11S_2147	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D11S_2148	COG2814	Major facilitator Superfamily
D11S_2151	COG1028	Short-chain dehydrogenase reductase Sdr
D11S_2152	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D11S_2154	COG0416	fatty acid biosynthetic process
D11S_2155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D11S_2156	COG1399	metal-binding, possibly nucleic acid-binding protein
D11S_2158	COG0500	methyltransferase
D11S_2165	COG3392	D12 class N6 adenine-specific DNA methyltransferase
D11S_2179	COG5003	unkown
D11S_2180	COG4387	Mu-like prophage protein GP36
D11S_2182	COG4397	Mu-like prophage major head subunit gpT
D11S_2183	COG4388	Caudovirus prohead serine protease
D11S_2184	COG5005	Phage virion morphogenesis
D11S_2185	COG2369	cell adhesion
D11S_2186	COG4383	Mu-like prophage protein gp29
D11S_2187	COG4373	Mu-like prophage FluMu protein gp28
D11S_2189	COG0640	Transcriptional regulator
D11S_2195	COG3023	N-Acetylmuramoyl-L-alanine amidase
D11S_2196	COG5566	PFAM Mor transcription activator
D11S_2197	COG4382	Mu-like prophage protein Gp16
D11S_2211	COG5301	cellulose 1,4-beta-cellobiosidase activity
D11S_2230	COG3566	protein conserved in bacteria
D11S_2231	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D11S_2233	COG2369	cell adhesion
D11S_2234	COG3567	Phage-associated protein, HI1409 family
D11S_2236	COG3728	DNA packaging
D11S_2240	COG3179	chitinase
D11S_2244	COG3617	BRO family, N-terminal domain
D11S_2248	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D11S_2253	COG1802	Transcriptional regulator
D11S_2253	COG4626	Terminase
D11S_2263	COG3617	BRO family, N-terminal domain
D11S_2273	COG0582	viral genome integration into host DNA
D11S_2289	COG2948	multi-organism process
D11S_2301	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D11S_2320	COG0629	single-stranded DNA binding
D11S_2321	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs