locus-tag	class	description
D7S_00003	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D7S_00005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D7S_00006	COG0314	molybdopterin synthase activity
D7S_00008	COG2969	positive regulation of protein catabolic process
D7S_00011	COG1940	carbohydrate kinase activity
D7S_00012	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D7S_00013	COG1070	Carbohydrate kinase
D7S_00014	COG2390	Transcriptional regulator
D7S_00021	COG0469	pyruvate kinase activity
D7S_00023	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_00025	COG0133	tryptophan synthase activity
D7S_00026	COG4221	oxidoreductase activity
D7S_00028	COG1629	transport
D7S_00028	COG4771	TonB-dependent receptor
D7S_00031	COG3630	sodium ion export across plasma membrane
D7S_00033	COG0298	carbon dioxide binding
D7S_00035	COG0134	indole-3-glycerol-phosphate synthase activity
D7S_00035	COG0135	phosphoribosylanthranilate isomerase activity
D7S_00036	COG3093	addiction module antidote protein HigA
D7S_00038	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D7S_00039	COG1942	4-Oxalocrotonate Tautomerase
D7S_00040	COG0512	Glutamine amidotransferase of anthranilate synthase
D7S_00041	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D7S_00042	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D7S_00043	COG0517	IMP dehydrogenase activity
D7S_00043	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D7S_00045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D7S_00051	COG0842	Transport permease protein
D7S_00052	COG0842	Transport permease protein
D7S_00052	COG1129	ABC transporter
D7S_00053	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_00055	COG1448	Aminotransferase
D7S_00056	COG0308	aminopeptidase N
D7S_00057	COG0167	dihydroorotate dehydrogenase activity
D7S_00058	COG0613	PHP domain protein
D7S_00060	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
D7S_00061	COG0589	response to stress
D7S_00062	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D7S_00064	COG1528	Iron-storage protein
D7S_00065	COG1528	Iron-storage protein
D7S_00066	COG2925	Exonuclease
D7S_00067	COG0697	spore germination
D7S_00068	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D7S_00069	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D7S_00070	COG0204	Acyl-transferase
D7S_00070	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_00072	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D7S_00073	COG1686	Belongs to the peptidase S11 family
D7S_00075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D7S_00076	COG0586	Pfam SNARE associated Golgi protein
D7S_00077	COG0058	SHG alpha-glucan phosphorylase activity
D7S_00080	COG1523	belongs to the glycosyl hydrolase 13 family
D7S_00088	COG3657	addiction module killer protein
D7S_00091	COG1346	cytolysis
D7S_00103	COG3005	denitrification pathway
D7S_00104	COG0243	molybdopterin cofactor binding
D7S_00105	COG2315	Protein conserved in bacteria
D7S_00106	COG0471	metal ion transport
D7S_00110	COG0101	tRNA pseudouridine synthase activity
D7S_00114	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7S_00115	COG1074	ATP-dependent DNA helicase activity
D7S_00116	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D7S_00118	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7S_00119	COG1067	ATP-dependent peptidase activity
D7S_00121	COG1278	Cold shock
D7S_00125	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D7S_00135	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_00137	COG3842	ATPase activity
D7S_00138	COG1178	ABC-type Fe3 transport system permease component
D7S_00139	COG3842	ATPase activity
D7S_00140	COG3101	peptidyl-lysine hydroxylation
D7S_00141	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D7S_00143	COG0788	formyltetrahydrofolate deformylase activity
D7S_00144	COG2916	Histone family protein nucleoid-structuring protein H-NS
D7S_00145	COG1757	Na H antiporter
D7S_00146	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D7S_00148	COG0251	oxidation-reduction process
D7S_00151	COG0463	Glycosyl transferase, family 2
D7S_00152	COG3021	interspecies interaction between organisms
D7S_00153	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D7S_00155	COG1560	Kdo2-lipid A biosynthetic process
D7S_00156	COG0730	response to heat
D7S_00157	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D7S_00158	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D7S_00159	COG3264	Mechanosensitive ion channel
D7S_00159	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D7S_00160	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_00161	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D7S_00162	COG0596	Alpha beta hydrolase
D7S_00163	COG0716	FMN binding
D7S_00164	COG0735	belongs to the Fur family
D7S_00165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7S_00166	COG3094	Invasion gene expression up-regulator, SirB
D7S_00167	COG0023	Translation Initiation Factor
D7S_00169	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D7S_00170	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
D7S_00171	COG0776	regulation of translation
D7S_00172	COG0539	negative regulation of cytoplasmic translation
D7S_00174	COG2990	Protein conserved in bacteria
D7S_00175	COG4771	TonB-dependent receptor
D7S_00176	COG0612	Peptidase, M16
D7S_00177	COG1687	branched-chain amino acid
D7S_00178	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D7S_00179	COG0583	DNA-binding transcription factor activity
D7S_00181	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D7S_00182	COG1518	maintenance of DNA repeat elements
D7S_00193	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D7S_00196	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_00199	COG0405	Gamma-glutamyltransferase
D7S_00207	COG0737	Belongs to the 5'-nucleotidase family
D7S_00208	COG4607	ABC-type enterochelin transport system periplasmic component
D7S_00209	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_00210	COG4605	iron ion homeostasis
D7S_00211	COG4604	ABC transporter, ATP-binding protein
D7S_00212	COG0739	heme binding
D7S_00214	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_00215	COG0733	neurotransmitter:sodium symporter activity
D7S_00223	COG4657	Part of a membrane complex involved in electron transport
D7S_00224	COG1090	epimerase
D7S_00225	COG1438	arginine binding
D7S_00227	COG0039	L-malate dehydrogenase activity
D7S_00229	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7S_00230	COG0583	DNA-binding transcription factor activity
D7S_00232	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7S_00233	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7S_00233	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D7S_00234	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7S_00236	COG0471	metal ion transport
D7S_00237	COG2005	Transcriptional regulator
D7S_00238	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7S_00239	COG4149	molybdate abc transporter
D7S_00240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D7S_00242	COG0795	lipopolysaccharide-transporting ATPase activity
D7S_00243	COG0795	lipopolysaccharide-transporting ATPase activity
D7S_00244	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D7S_00246	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D7S_00249	COG0309	Hydrogenase expression formation protein (HypE)
D7S_00250	COG0409	Hydrogenase expression formation protein
D7S_00251	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D7S_00254	COG0310	cobalt ion transport
D7S_00255	COG0310	cobalt ion transport
D7S_00258	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D7S_00259	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_00260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D7S_00261	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_00263	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D7S_00286	COG2271	Major facilitator Superfamily
D7S_00288	COG3718	enzyme involved in inositol metabolism
D7S_00294	COG3501	Rhs element vgr protein
D7S_00296	COG1609	Transcriptional regulator
D7S_00297	COG2949	membrane
D7S_00298	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D7S_00303	COG0583	DNA-binding transcription factor activity
D7S_00305	COG0009	L-threonylcarbamoyladenylate synthase
D7S_00306	COG0287	Prephenate dehydrogenase
D7S_00306	COG1605	Chorismate mutase
D7S_00307	COG0616	signal peptide processing
D7S_00308	COG0778	Nitroreductase
D7S_00311	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7S_00312	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7S_00314	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D7S_00316	COG2909	trisaccharide binding
D7S_00317	COG0058	SHG alpha-glucan phosphorylase activity
D7S_00318	COG1640	4-alpha-glucanotransferase
D7S_00320	COG1286	toxin biosynthetic process
D7S_00321	COG3092	negative regulation of chromosome organization
D7S_00323	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D7S_00324	COG0857	belongs to the CobB CobQ family
D7S_00324	COG0280	phosphate acetyltransferase
D7S_00326	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D7S_00327	COG0617	tRNA 3'-terminal CCA addition
D7S_00328	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D7S_00329	COG0658	competence protein
D7S_00329	COG2333	competence protein COMEC
D7S_00330	COG1132	(ABC) transporter
D7S_00331	COG1663	tetraacyldisaccharide 4'-kinase activity
D7S_00332	COG2835	tetraacyldisaccharide 4'-kinase activity
D7S_00334	COG0322	excinuclease ABC activity
D7S_00336	COG0395	ABC-type sugar transport system, permease component
D7S_00337	COG1175	transmembrane transport
D7S_00343	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D7S_00344	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D7S_00346	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D7S_00350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D7S_00352	COG0195	Participates in both transcription termination and antitermination
D7S_00371	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D7S_00372	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D7S_00374	COG0024	Methionine aminopeptidase
D7S_00375	COG0316	Belongs to the HesB IscA family
D7S_00377	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7S_00378	COG0672	)-iron permease
D7S_00381	COG1136	(ABC) transporter
D7S_00381	COG0577	efflux transmembrane transporter activity
D7S_00383	COG1136	(ABC) transporter
D7S_00383	COG0577	efflux transmembrane transporter activity
D7S_00384	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_00386	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7S_00389	COG1643	Atp-dependent helicase
D7S_00390	COG2363	Small membrane protein
D7S_00395	COG0277	FAD linked oxidase domain protein
D7S_00395	COG0247	lactate metabolic process
D7S_00398	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D7S_00400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D7S_00401	COG0363	glucosamine-6-phosphate deaminase activity
D7S_00402	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7S_00403	COG1737	Transcriptional regulator
D7S_00405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D7S_00406	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D7S_00407	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7S_00407	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D7S_00408	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
D7S_00409	COG2190	(PTS) system
D7S_00409	COG1263	PTS System
D7S_00409	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_00411	COG3501	Rhs element vgr protein
D7S_00414	COG3179	chitinase
D7S_00428	COG1846	Transcriptional regulator
D7S_00428	COG1940	carbohydrate kinase activity
D7S_00430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7S_00431	COG2226	methyltransferase
D7S_00434	COG3422	double-strand break repair
D7S_00436	COG1944	ATP diphosphatase activity
D7S_00437	COG3105	Protein conserved in bacteria
D7S_00439	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D7S_00443	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D7S_00444	COG3683	transport system, periplasmic component
D7S_00445	COG0488	(ABC) transporter
D7S_00447	COG0187	DNA topoisomerase II activity
D7S_00448	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D7S_00449	COG0625	glutathione transferase activity
D7S_00450	COG3047	cAMP biosynthetic process
D7S_00450	COG2885	chlorophyll binding
D7S_00451	COG0616	signal peptide processing
D7S_00454	COG1252	NADH dehydrogenase
D7S_00456	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D7S_00458	COG0792	nuclease activity
D7S_00459	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D7S_00460	COG2823	Periplasmic or secreted lipoprotein
D7S_00461	COG0288	reversible hydration of carbon dioxide
D7S_00462	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7S_00462	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D7S_00463	COG0785	Cytochrome C biogenesis protein
D7S_00464	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_00470	COG3069	C4-dicarboxylate transmembrane transporter activity
D7S_00471	COG3077	Addiction module antitoxin, RelB DinJ family
D7S_00472	COG3041	Addiction module toxin RelE StbE family
D7S_00475	COG0825	malonyl-CoA metabolic process
D7S_00478	COG2252	PERMEase
D7S_00479	COG3152	Membrane
D7S_00480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D7S_00481	COG0375	protein maturation
D7S_00484	COG0563	adenylate kinase activity
D7S_00486	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D7S_00487	COG3025	triphosphatase activity
D7S_00488	COG1392	Phosphate transport regulator
D7S_00489	COG0306	phosphate transporter
D7S_00490	COG4991	sh3 domain protein
D7S_00491	COG0617	tRNA 3'-terminal CCA addition
D7S_00492	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D7S_00493	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D7S_00497	COG1620	l-lactate permease
D7S_00505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D7S_00507	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7S_00511	COG2026	Addiction module toxin, RelE StbE family
D7S_00527	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D7S_00530	COG1862	Preprotein translocase
D7S_00531	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7S_00532	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D7S_00535	COG1012	belongs to the aldehyde dehydrogenase family
D7S_00535	COG1454	alcohol dehydrogenase
D7S_00536	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_00537	COG1129	ABC transporter
D7S_00538	COG1879	ABC-type sugar transport system periplasmic component
D7S_00540	COG0673	inositol 2-dehydrogenase activity
D7S_00549	COG0720	synthase
D7S_00550	COG0602	queuosine metabolic process
D7S_00551	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D7S_00552	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D7S_00554	COG0783	Belongs to the Dps family
D7S_00558	COG2814	Major facilitator Superfamily
D7S_00566	COG2927	DNA polymerase III (CHI subunit)
D7S_00567	COG0114	fumarate hydratase activity
D7S_00568	COG2268	Band 7 protein
D7S_00571	COG0778	Nitroreductase
D7S_00572	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7S_00574	COG0814	amino acid
D7S_00580	COG0235	Class ii aldolase
D7S_00581	COG3623	hexulose-6-phosphate isomerase
D7S_00586	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D7S_00594	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_00596	COG3962	Belongs to the TPP enzyme family
D7S_00598	COG0673	inositol 2-dehydrogenase activity
D7S_00599	COG3722	fumarate hydratase activity
D7S_00600	COG0246	Mannitol dehydrogenase
D7S_00602	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_00603	COG2274	protein secretion by the type I secretion system
D7S_00604	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D7S_00605	COG2994	toxin metabolic process
D7S_00607	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D7S_00611	COG2813	Specifically methylates the guanine in position
D7S_00612	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
D7S_00614	COG0456	acetyltransferase
D7S_00615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D7S_00618	COG4795	General secretion pathway protein
D7S_00619	COG2165	general secretion pathway protein
D7S_00625	COG3064	Membrane
D7S_00626	COG0848	biopolymer transport protein
D7S_00627	COG0811	peptide transport
D7S_00628	COG0824	Thioesterase
D7S_00629	COG1294	oxidase, subunit
D7S_00630	COG1271	oxidase subunit
D7S_00636	COG0217	transcriptional regulatory protein
D7S_00637	COG0494	nUDIX hydrolase
D7S_00643	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D7S_00644	COG1755	Isoprenylcysteine carboxyl methyltransferase
D7S_00647	COG2271	Major facilitator Superfamily
D7S_00651	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D7S_00653	COG2056	Na+-H+ antiporter family
D7S_00658	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D7S_00659	COG0142	geranyltranstransferase activity
D7S_00662	COG0697	spore germination
D7S_00663	COG0697	spore germination
D7S_00664	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D7S_00668	COG4166	transmembrane transport
D7S_00672	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D7S_00673	COG0444	Belongs to the ABC transporter superfamily
D7S_00674	COG4608	Belongs to the ABC transporter superfamily
D7S_00675	COG0745	RESPONSE REGULATOR receiver
D7S_00676	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D7S_00678	COG1611	Belongs to the LOG family
D7S_00680	COG2259	Doxx family
D7S_00682	COG1530	ribonuclease E activity
D7S_00686	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7S_00687	COG0626	cystathionine gamma-synthase activity
D7S_00702	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D7S_00703	COG1959	2 iron, 2 sulfur cluster binding
D7S_00705	COG0822	iron-sulfur transferase activity
D7S_00708	COG0443	Heat shock 70 kDa protein
D7S_00709	COG0633	Ferredoxin
D7S_00710	COG2975	iron-sulfur cluster assembly
D7S_00711	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7S_00711	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D7S_00712	COG0489	protein tyrosine kinase activity
D7S_00721	COG0590	tRNA wobble adenosine to inosine editing
D7S_00722	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D7S_00724	COG0730	response to heat
D7S_00726	COG1869	D-ribose catabolic process
D7S_00728	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_00729	COG1879	ABC-type sugar transport system periplasmic component
D7S_00730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_00731	COG1278	Cold shock
D7S_00737	COG0165	Argininosuccinate lyase
D7S_00738	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D7S_00739	COG0753	catalase activity
D7S_00743	COG0587	DNA-directed DNA polymerase activity
D7S_00744	COG1022	Amp-dependent synthetase and ligase
D7S_00748	COG1328	CTP reductase activity
D7S_00748	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D7S_00749	COG0602	queuosine metabolic process
D7S_00750	COG0084	hydrolase, TatD family'
D7S_00753	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D7S_00764	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
D7S_00765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D7S_00771	COG2960	long-chain fatty acid transporting porin activity
D7S_00773	COG3172	ATPase kinase involved in NAD metabolism
D7S_00774	COG2129	metallophosphoesterase
D7S_00776	COG0814	amino acid
D7S_00779	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D7S_00783	COG0201	protein transport
D7S_00786	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D7S_00788	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D7S_00792	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D7S_00795	COG0805	protein transport
D7S_00796	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7S_00797	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D7S_00804	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D7S_00805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D7S_00806	COG1011	Hydrolase
D7S_00807	COG0494	nUDIX hydrolase
D7S_00808	COG1917	Cupin 2, conserved barrel domain protein
D7S_00808	COG4977	sequence-specific DNA binding
D7S_00809	COG3059	membrane
D7S_00810	COG1297	OPT oligopeptide transporter protein
D7S_00812	COG1218	3'(2'),5'-bisphosphate nucleotidase
D7S_00813	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D7S_00814	COG0363	glucosamine-6-phosphate deaminase activity
D7S_00820	COG0762	integral membrane protein
D7S_00822	COG0778	Nitroreductase
D7S_00831	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D7S_00834	COG0006	proline dipeptidase activity
D7S_00839	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D7S_00840	COG1792	Involved in formation and maintenance of cell shape
D7S_00841	COG1077	Cell shape determining protein MreB Mrl
D7S_00842	COG0557	exoribonuclease II activity
D7S_00845	COG2271	Major facilitator Superfamily
D7S_00846	COG0584	glycerophosphoryl diester phosphodiesterase
D7S_00847	COG0758	DNA mediated transformation
D7S_00855	COG1132	(ABC) transporter
D7S_00856	COG4977	sequence-specific DNA binding
D7S_00856	COG1917	Cupin 2, conserved barrel domain protein
D7S_00857	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D7S_00858	COG0859	PFAM glycosyl transferase family 9
D7S_00861	COG1519	Transferase
D7S_00862	COG0463	Glycosyl transferase, family 2
D7S_00865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7S_00866	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D7S_00867	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7S_00868	COG3719	Belongs to the RNase T2 family
D7S_00870	COG0191	fructose-bisphosphate aldolase activity
D7S_00871	COG3307	-O-antigen
D7S_00872	COG0561	phosphatase activity
D7S_00873	COG0028	Belongs to the TPP enzyme family
D7S_00876	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7S_00881	COG1072	(Pantothenic acid kinase))
D7S_00882	COG0187	DNA topoisomerase II activity
D7S_00883	COG0514	ATP-dependent DNA helicase (RecQ)
D7S_00886	COG0019	diaminopimelate decarboxylase activity
D7S_00887	COG3477	response to acidic pH
D7S_00888	COG2818	Glycosylase
D7S_00889	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D7S_00891	COG2195	Cleaves the N-terminal amino acid of tripeptides
D7S_00892	COG0300	oxidoreductase activity
D7S_00893	COG1763	Mo-molybdopterin cofactor biosynthetic process
D7S_00894	COG3086	response to oxidative stress
D7S_00895	COG3026	antisigma factor binding
D7S_00896	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
D7S_00897	COG1595	DNA-templated transcription, initiation
D7S_00900	COG0442	prolyl-tRNA aminoacylation
D7S_00901	COG1921	L-seryl-tRNASec selenium transferase activity
D7S_00902	COG3276	selenocysteine insertion sequence binding
D7S_00916	COG0521	Mo-molybdopterin cofactor biosynthetic process
D7S_00917	COG4589	Belongs to the CDS family
D7S_00919	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7S_00920	COG0490	domain, Protein
D7S_00920	COG0471	metal ion transport
D7S_00924	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D7S_00926	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D7S_00929	COG0575	Belongs to the CDS family
D7S_00932	COG0233	cytoplasmic translational termination
D7S_00936	COG4178	(ABC) transporter
D7S_00939	COG1349	DNA-binding transcription factor activity
D7S_00940	COG0705	Rhomboid family
D7S_00945	COG0551	DNA topoisomerase type I activity
D7S_00948	COG2962	Rard protein
D7S_00949	COG0583	DNA-binding transcription factor activity
D7S_00955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D7S_00956	COG1879	ABC-type sugar transport system periplasmic component
D7S_00957	COG1129	ABC transporter
D7S_00958	COG1172	Belongs to the binding-protein-dependent transport system permease family
D7S_00960	COG2183	response to ionizing radiation
D7S_00965	COG0583	DNA-binding transcription factor activity
D7S_00966	COG0471	metal ion transport
D7S_00968	COG2183	response to ionizing radiation
D7S_00969	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7S_00971	COG1595	DNA-templated transcription, initiation
D7S_00973	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D7S_00974	COG3071	HemY protein
D7S_00975	COG2959	enzyme of heme biosynthesis
D7S_00977	COG0181	hydroxymethylbilane synthase activity
D7S_00979	COG2197	response regulator
D7S_00980	COG0729	surface antigen
D7S_00981	COG2911	Protein conserved in bacteria
D7S_00982	COG0248	Ppx GppA phosphatase
D7S_00987	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D7S_00988	COG3068	Protein conserved in bacteria
D7S_00990	COG1349	DNA-binding transcription factor activity
D7S_00991	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D7S_00995	COG2272	Belongs to the type-B carboxylesterase lipase family
D7S_00996	COG0667	Aldo Keto reductase
D7S_00997	COG0656	L-ascorbic acid biosynthetic process
D7S_01000	COG0433	COG0433 Predicted ATPase
D7S_01001	COG2258	MOSC domain
D7S_01002	COG3012	SEC-C Motif Domain Protein
D7S_01005	COG1490	D-aminoacyl-tRNA deacylase activity
D7S_01006	COG0786	glutamate:sodium symporter activity
D7S_01007	COG2205	protein histidine kinase activity
D7S_01008	COG0745	RESPONSE REGULATOR receiver
D7S_01009	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D7S_01011	COG3082	Protein of unknown function (DUF1414)
D7S_01012	COG3083	sulfuric ester hydrolase activity
D7S_01014	COG0402	S-adenosylhomocysteine deaminase activity
D7S_01015	COG3956	TIGRFAM MazG family protein
D7S_01018	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D7S_01020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D7S_01021	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
D7S_01023	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D7S_01026	COG0148	phosphopyruvate hydratase activity
D7S_01029	COG2991	Protein conserved in bacteria
D7S_01030	COG1477	protein flavinylation
D7S_01031	COG2871	sodium ion transport
D7S_01032	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_01033	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_01034	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D7S_01039	COG0271	Belongs to the BolA IbaG family
D7S_01040	COG3056	Lipoprotein
D7S_01045	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D7S_01046	COG1194	a g-specific adenine glycosylase
D7S_01048	COG3171	Protein conserved in bacteria
D7S_01049	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_01050	COG1178	ABC-type Fe3 transport system permease component
D7S_01051	COG3842	ATPase activity
D7S_01054	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D7S_01058	COG0354	folic acid binding
D7S_01061	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D7S_01064	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D7S_01065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7S_01066	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D7S_01068	COG0500	methyltransferase
D7S_01069	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D7S_01070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_01071	COG1309	transcriptional regulator
D7S_01072	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_01073	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D7S_01076	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_01078	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_01082	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D7S_01091	COG1309	transcriptional regulator
D7S_01094	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D7S_01095	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D7S_01096	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D7S_01097	COG4972	Pilus assembly protein
D7S_01101	COG4796	Type ii and iii secretion system protein
D7S_01104	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D7S_01110	COG0653	protein targeting
D7S_01113	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D7S_01118	COG0789	Transcriptional regulator
D7S_01119	COG4701	Protein of unknown function (DUF721)
D7S_01122	COG0494	nUDIX hydrolase
D7S_01123	COG1466	dna polymerase III delta subunit
D7S_01124	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D7S_01131	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D7S_01132	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D7S_01133	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7S_01137	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D7S_01138	COG4221	oxidoreductase activity
D7S_01139	COG0789	Transcriptional regulator
D7S_01140	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D7S_01141	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D7S_01143	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D7S_01144	COG4137	Cytochrome C assembly protein
D7S_01146	COG4536	flavin adenine dinucleotide binding
D7S_01148	COG0811	peptide transport
D7S_01149	COG0848	biopolymer transport protein
D7S_01151	COG4783	chaperone-mediated protein folding
D7S_01153	COG0814	amino acid
D7S_01159	COG0747	negative chemotaxis
D7S_01160	COG2853	Lipoprotein
D7S_01169	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D7S_01170	COG3610	response to peptide
D7S_01171	COG2966	Psort location CytoplasmicMembrane, score
D7S_01174	COG0545	Peptidyl-prolyl cis-trans isomerase
D7S_01175	COG0688	phosphatidylethanolamine metabolic process
D7S_01176	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D7S_01178	COG2830	Protein of unknown function (DUF452)
D7S_01179	COG0500	methyltransferase
D7S_01181	COG1399	metal-binding, possibly nucleic acid-binding protein
D7S_01182	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D7S_01183	COG0416	fatty acid biosynthetic process
D7S_01185	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D7S_01186	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_01189	COG2814	Major facilitator Superfamily
D7S_01190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D7S_01191	COG0513	Belongs to the DEAD box helicase family
D7S_01192	COG0799	negative regulation of ribosome biogenesis
D7S_01194	COG0768	penicillin binding
D7S_01195	COG0772	Belongs to the SEDS family
D7S_01196	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_01196	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D7S_01197	COG1686	Belongs to the peptidase S11 family
D7S_01204	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7S_01205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7S_01206	COG0765	amino acid transport
D7S_01207	COG1126	abc transporter atp-binding protein
D7S_01208	COG2168	tRNA wobble position uridine thiolation
D7S_01210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D7S_01211	COG2964	Protein conserved in bacteria
D7S_01212	COG0545	Peptidyl-prolyl cis-trans isomerase
D7S_01214	COG0678	peroxiredoxin activity
D7S_01214	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D7S_01215	COG0583	DNA-binding transcription factor activity
D7S_01216	COG1309	transcriptional regulator
D7S_01217	COG1132	(ABC) transporter
D7S_01218	COG4988	ABC transporter
D7S_01220	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D7S_01221	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D7S_01222	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D7S_01224	COG1045	serine acetyltransferase
D7S_01226	COG1494	fructose-1,6-bisphosphatase
D7S_01228	COG0716	FMN binding
D7S_01233	COG1733	regulation of RNA biosynthetic process
D7S_01235	COG3312	ion transport
D7S_01239	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D7S_01241	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D7S_01244	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7S_01245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D7S_01247	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D7S_01249	COG1349	DNA-binding transcription factor activity
D7S_01257	COG3501	Rhs element vgr protein
D7S_01281	COG0459	protein refolding
D7S_01282	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D7S_01284	COG1027	Aspartate ammonia-lyase
D7S_01285	COG0859	PFAM glycosyl transferase family 9
D7S_01286	COG3716	PTS system mannose fructose sorbose family IID component
D7S_01287	COG3715	PTS system
D7S_01288	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_01288	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_01289	COG2814	Major facilitator Superfamily
D7S_01290	COG0662	Cupin 2, conserved barrel domain protein
D7S_01290	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D7S_01295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_01297	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D7S_01299	COG0297	glycogen (starch) synthase activity
D7S_01303	COG1757	Na H antiporter
D7S_01304	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D7S_01305	COG4214	carbohydrate transport
D7S_01306	COG1129	ABC transporter
D7S_01307	COG4213	ABC transporter substrate-binding protein
D7S_01308	COG2115	Belongs to the xylose isomerase family
D7S_01313	COG3070	regulator of competence-specific genes
D7S_01314	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7S_01317	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D7S_01318	COG3850	Histidine kinase
D7S_01320	COG3062	negative regulation of establishment of protein localization
D7S_01323	COG0437	4 iron, 4 sulfur cluster binding
D7S_01324	COG0348	domain, Protein
D7S_01325	COG3043	anaerobic respiration
D7S_01326	COG3005	denitrification pathway
D7S_01327	COG0754	glutathionylspermidine amidase activity
D7S_01328	COG0859	PFAM glycosyl transferase family 9
D7S_01330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D7S_01332	COG0737	Belongs to the 5'-nucleotidase family
D7S_01337	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_01338	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_01340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_01351	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D7S_01356	COG1011	Hydrolase
D7S_01358	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D7S_01359	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D7S_01363	COG1596	polysaccharide export
D7S_01363	COG1555	photosystem II stabilization
D7S_01364	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7S_01365	COG0561	phosphatase activity
D7S_01366	COG1040	competence protein
D7S_01369	COG1114	Component of the transport system for branched-chain amino acids
D7S_01374	COG4804	nuclease activity
D7S_01376	COG4545	Glutaredoxin-related protein
D7S_01379	COG3381	protein complex oligomerization
D7S_01380	COG3302	dmso reductase anchor subunit
D7S_01381	COG0437	4 iron, 4 sulfur cluster binding
D7S_01382	COG0243	molybdopterin cofactor binding
D7S_01384	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7S_01384	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D7S_01386	COG5645	(Lipo)protein
D7S_01387	COG0210	DNA helicase
D7S_01392	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D7S_01393	COG0110	maltose O-acetyltransferase activity
D7S_01394	COG1238	metal cluster binding
D7S_01413	COG3561	AntA/AntB antirepressor
D7S_01422	COG0582	viral genome integration into host DNA
D7S_01425	COG2095	MarC family integral membrane protein
D7S_01427	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D7S_01428	COG2137	regulation of response to DNA damage stimulus
D7S_01429	COG0251	oxidation-reduction process
D7S_01431	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D7S_01453	COG4964	Belongs to the GSP D family
D7S_01459	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D7S_01462	COG1444	tRNA N-acetyltransferase activity
D7S_01465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D7S_01467	COG1126	abc transporter atp-binding protein
D7S_01468	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D7S_01469	COG4215	(ABC) transporter
D7S_01470	COG4160	amino acid transport
D7S_01471	COG1966	Carbon starvation protein
D7S_01474	COG3116	cell division
D7S_01475	COG0768	penicillin binding
D7S_01477	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D7S_01481	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D7S_01485	COG0849	cell division
D7S_01486	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D7S_01488	COG0077	Prephenate dehydratase
D7S_01488	COG1605	Chorismate mutase
D7S_01489	COG0326	Molecular chaperone. Has ATPase activity
D7S_01490	COG1393	Belongs to the ArsC family
D7S_01492	COG1876	peptidase activity
D7S_01493	COG0494	nUDIX hydrolase
D7S_01494	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D7S_01501	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
D7S_01503	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D7S_01504	COG1053	succinate dehydrogenase
D7S_01506	COG1120	ATPase activity
D7S_01509	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D7S_01510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D7S_01511	COG1408	metallophosphoesterase
D7S_01513	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D7S_01514	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D7S_01516	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7S_01520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D7S_01522	COG0741	lytic transglycosylase activity
D7S_01523	COG2350	Protein conserved in bacteria
D7S_01524	COG1607	acyl-coa hydrolase
D7S_01525	COG2917	probably involved in intracellular septation
D7S_01529	COG0497	DNA recombination
D7S_01532	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D7S_01536	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D7S_01537	COG0784	Response regulator, receiver
D7S_01537	COG2198	Histidine kinase
D7S_01537	COG5002	protein histidine kinase activity
D7S_01538	COG4211	Belongs to the binding-protein-dependent transport system permease family
D7S_01542	COG1879	ABC-type sugar transport system periplasmic component
D7S_01543	COG1609	Transcriptional regulator
D7S_01544	COG1085	galactose-1-phosphate uridylyltransferase
D7S_01546	COG2017	converts alpha-aldose to the beta-anomer
D7S_01550	COG0471	metal ion transport
D7S_01551	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
D7S_01551	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D7S_01552	COG3051	citrate lyase alpha subunit
D7S_01553	COG2301	Belongs to the HpcH HpaI aldolase family
D7S_01555	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D7S_01557	COG4535	Mg2 and Co2 transporter CorC
D7S_01562	COG0105	UTP biosynthetic process
D7S_01566	COG1388	LysM domain
D7S_01566	COG4942	peptidase
D7S_01568	COG1238	metal cluster binding
D7S_01573	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D7S_01576	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7S_01577	COG0733	neurotransmitter:sodium symporter activity
D7S_01579	COG1285	pathogenesis
D7S_01590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D7S_01590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7S_01590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D7S_01591	COG1105	Belongs to the carbohydrate kinase PfkB family
D7S_01592	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_01592	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_01594	COG0746	molybdenum cofactor guanylyltransferase activity
D7S_01595	COG3084	Protein conserved in bacteria
D7S_01596	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D7S_01597	COG3085	chromosome segregation
D7S_01606	COG0561	phosphatase activity
D7S_01608	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D7S_01610	COG2610	gluconate transmembrane transporter activity
D7S_01611	COG3622	Belongs to the hyi family
D7S_01612	COG0235	Class ii aldolase
D7S_01613	COG3395	kinase activity
D7S_01614	COG2084	Dehydrogenase
D7S_01615	COG1349	DNA-binding transcription factor activity
D7S_01616	COG0347	Belongs to the P(II) protein family
D7S_01617	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D7S_01618	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D7S_01619	COG0470	DNA polymerase III
D7S_01620	COG0084	hydrolase, TatD family'
D7S_01629	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D7S_01630	COG4942	peptidase
D7S_01631	COG2861	carbohydrate metabolic process
D7S_01632	COG0606	chelatase, subunit chli
D7S_01634	COG2990	Protein conserved in bacteria
D7S_01635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D7S_01639	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D7S_01650	COG0513	Belongs to the DEAD box helicase family
D7S_01653	COG3201	nicotinamide mononucleotide transporter
D7S_01656	COG3078	GTPase activator activity
D7S_01658	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7S_01659	COG0456	acetyltransferase
D7S_01661	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D7S_01666	COG0511	ligase activity, forming carbon-carbon bonds
D7S_01667	COG0439	Biotin carboxylase
D7S_01671	COG3924	membrane
D7S_01672	COG4145	pantothenate transmembrane transporter activity
D7S_01673	COG2184	nucleotidyltransferase activity
D7S_01679	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D7S_01680	COG1115	amino acid carrier protein
D7S_01685	COG2801	Transposase and inactivated derivatives
D7S_01690	COG2918	glutathione biosynthetic process
D7S_01690	COG1181	Belongs to the D-alanine--D-alanine ligase family
D7S_01692	COG2194	sulfuric ester hydrolase activity
D7S_01693	COG0740	serine-type endopeptidase activity
D7S_01697	COG3739	integral membrane protein
D7S_01698	COG2217	Heavy metal translocating P-type atpase
D7S_01699	COG2608	mercury ion transmembrane transporter activity
D7S_01703	COG2932	Transcriptional regulator
D7S_01708	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D7S_01712	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D7S_01721	COG1459	type II secretion system
D7S_01722	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D7S_01723	COG4969	Belongs to the N-Me-Phe pilin family
D7S_01724	COG3023	N-Acetylmuramoyl-L-alanine amidase
D7S_01726	COG2731	YhcH YjgK YiaL family protein
D7S_01728	COG4785	May be involved in cell division
D7S_01729	COG0513	Belongs to the DEAD box helicase family
D7S_01732	COG3835	regulator
D7S_01733	COG2610	gluconate transmembrane transporter activity
D7S_01734	COG1929	Belongs to the glycerate kinase type-1 family
D7S_01735	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D7S_01736	COG0312	modulator of DNA gyrase
D7S_01737	COG3028	Belongs to the UPF0307 family
D7S_01738	COG0471	metal ion transport
D7S_01740	COG1575	Belongs to the MenA family. Type 1 subfamily
D7S_01741	COG1720	tRNA m6t6A37 methyltransferase activity
D7S_01747	COG2177	Part of the ABC transporter FtsEX involved in
D7S_01748	COG2884	Cell division ATP-binding protein ftsE
D7S_01750	COG0552	protein localization to endoplasmic reticulum
D7S_01751	COG0742	ribosomal rna small subunit methyltransferase
D7S_01753	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D7S_01753	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_01754	COG3715	PTS system
D7S_01755	COG3716	PTS system mannose fructose sorbose family IID component
D7S_01756	COG0561	phosphatase activity
D7S_01757	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D7S_01763	COG1215	transferase activity, transferring glycosyl groups
D7S_01766	COG2271	Major facilitator Superfamily
D7S_01771	COG2801	Transposase and inactivated derivatives
D7S_01774	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D7S_01776	COG1758	RNA polymerase activity
D7S_01777	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D7S_01779	COG3161	chorismate lyase activity
D7S_01788	COG0569	domain protein
D7S_01790	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D7S_01793	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D7S_01794	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D7S_01795	COG3036	rescue of stalled ribosome
D7S_01797	COG1393	Belongs to the ArsC family
D7S_01799	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D7S_01800	COG1522	sequence-specific DNA binding
D7S_01802	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D7S_01803	COG0038	chloride channel
D7S_01804	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D7S_01805	COG0549	Belongs to the carbamate kinase family
D7S_01806	COG1288	antiporter activity
D7S_01808	COG0183	Belongs to the thiolase family
D7S_01809	COG2031	fatty acid transporter
D7S_01810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D7S_01811	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D7S_01812	COG0583	DNA-binding transcription factor activity
D7S_01813	COG0051	transcription antitermination factor activity, RNA binding
D7S_01814	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D7S_01816	COG0089	rRNA binding
D7S_01817	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D7S_01818	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D7S_01819	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D7S_01820	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D7S_01821	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D7S_01822	COG0255	Belongs to the universal ribosomal protein uL29 family
D7S_01823	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D7S_01829	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D7S_01831	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D7S_01833	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D7S_01838	COG3115	cell septum assembly
D7S_01840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D7S_01842	COG1573	uracil-dna glycosylase
D7S_01844	COG0012	GTP binding
D7S_01845	COG0193	aminoacyl-tRNA hydrolase activity
D7S_01847	COG0560	Phosphoserine phosphatase
D7S_01850	COG0728	peptidoglycan biosynthetic process
D7S_01851	COG0196	riboflavin kinase activity
D7S_01855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D7S_01857	COG1555	photosystem II stabilization
D7S_01858	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D7S_01860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D7S_01861	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D7S_01862	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D7S_01864	COG0800	Aldolase
D7S_01866	COG1028	Short-chain dehydrogenase reductase Sdr
D7S_01867	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D7S_01873	COG2186	Transcriptional regulator
D7S_01877	COG0659	secondary active sulfate transmembrane transporter activity
D7S_01879	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D7S_01880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D7S_01881	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D7S_01882	COG2233	PERMEase
D7S_01884	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7S_01886	COG2976	Protein conserved in bacteria
D7S_01889	COG1426	Protein conserved in bacteria
D7S_01890	COG3063	Type IV pilus biogenesis stability protein PilW
D7S_01893	COG0252	asparaginase activity
D7S_01894	COG1760	l-serine dehydratase
D7S_01895	COG0814	amino acid
D7S_01896	COG3091	SprT-like family
D7S_01906	COG0281	malic enzyme
D7S_01906	COG0280	phosphate acetyltransferase
D7S_01909	COG2321	neutral zinc metallopeptidase
D7S_01910	COG1652	LysM domain
D7S_01912	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D7S_01913	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D7S_01915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D7S_01918	COG0436	Aminotransferase
D7S_01920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D7S_01921	COG2267	carboxylic ester hydrolase activity
D7S_01934	COG2814	Major facilitator Superfamily
D7S_01935	COG4133	protoheme IX ABC transporter activity
D7S_01936	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_01937	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_01938	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D7S_01940	COG1138	Cytochrome C-type biogenesis protein
D7S_01947	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D7S_01948	COG0437	4 iron, 4 sulfur cluster binding
D7S_01949	COG3301	Polysulphide reductase, NrfD
D7S_01950	COG1138	Cytochrome C-type biogenesis protein
D7S_01951	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D7S_01952	COG4235	cytochrome complex assembly
D7S_01952	COG3088	subunit of a heme lyase
D7S_01953	COG2081	HI0933 family
D7S_01955	COG2226	methyltransferase
D7S_01957	COG0592	DNA-directed DNA polymerase activity
D7S_01958	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D7S_01959	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D7S_01965	COG0681	Belongs to the peptidase S26 family
D7S_01968	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D7S_01977	COG0537	adenosine 5'-monophosphoramidase activity
D7S_01978	COG2116	formate transmembrane transporter activity
D7S_01979	COG1882	Formate acetyltransferase
D7S_01980	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D7S_01981	COG0697	spore germination
D7S_01983	COG0204	Acyl-transferase
D7S_01985	COG5413	integral membrane protein
D7S_01986	COG2964	Protein conserved in bacteria
D7S_01987	COG0814	amino acid
D7S_01988	COG3033	Beta-eliminating lyase
D7S_01990	COG1509	lysine 2,3-aminomutase activity
D7S_01991	COG3061	Opacity-associated protein A
D7S_01991	COG3266	domain, Protein
D7S_01994	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D7S_01995	COG4974	Belongs to the 'phage' integrase family
D7S_01996	COG0544	peptidyl-prolyl cis-trans isomerase activity
D7S_01998	COG0330	HflC and HflK could
D7S_01999	COG0330	HflC and HflK could
D7S_02000	COG2091	lysine biosynthetic process via aminoadipic acid
D7S_02001	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D7S_02004	COG0460	homoserine dehydrogenase
D7S_02004	COG0527	aspartate kinase activity
D7S_02008	COG0517	IMP dehydrogenase activity
D7S_02008	COG1125	glycine betaine transport
D7S_02011	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D7S_02012	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D7S_02016	COG0861	Integral membrane protein TerC family
D7S_02018	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D7S_02020	COG3691	Protein conserved in bacteria
D7S_02022	COG5007	Belongs to the BolA IbaG family
D7S_02023	COG3113	response to antibiotic
D7S_02024	COG2854	intermembrane phospholipid transfer
D7S_02025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D7S_02026	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D7S_02027	COG1127	ABC transporter
D7S_02029	COG3117	lipopolysaccharide transmembrane transporter activity
D7S_02030	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D7S_02031	COG1137	ATPase activity
D7S_02032	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_02034	COG1570	exodeoxyribonuclease VII activity
D7S_02035	COG2850	peptidyl-arginine hydroxylation
D7S_02040	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D7S_02041	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D7S_02042	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D7S_02043	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D7S_02045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D7S_02049	COG2860	membrane
D7S_02054	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_02055	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_02065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D7S_02066	COG1530	ribonuclease E activity
D7S_02067	COG2999	glutathione oxidoreductase activity
D7S_02068	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D7S_02072	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D7S_02073	COG0626	cystathionine gamma-synthase activity
D7S_02076	COG2337	Toxic component of a toxin-antitoxin (TA) module
D7S_02077	COG0484	heat shock protein binding
D7S_02078	COG0443	Heat shock 70 kDa protein
D7S_02083	COG0725	ABC transporter, periplasmic molybdate-binding protein
D7S_02084	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D7S_02085	COG3842	ATPase activity
D7S_02086	COG0157	Belongs to the NadC ModD family
D7S_02089	COG2855	membrane
D7S_02090	COG4953	penicillin-binding protein 1C
D7S_02101	COG3959	Transketolase, thiamine diphosphate binding domain
D7S_02102	COG3958	Transketolase
D7S_02105	COG1289	transmembrane transporter activity
D7S_02106	COG3304	Inner membrane component domain
D7S_02107	COG1803	Methylglyoxal synthase
D7S_02110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_02111	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D7S_02112	COG1121	(ABC) transporter
D7S_02114	COG2920	part of a sulfur-relay system
D7S_02118	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D7S_02121	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D7S_02131	COG0351	phosphomethylpyrimidine kinase
D7S_02131	COG0351	phosphomethylpyrimidine kinase
D7S_02132	COG4143	(ABC) transporter
D7S_02133	COG1178	ABC-type Fe3 transport system permease component
D7S_02134	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D7S_02137	COG1522	sequence-specific DNA binding
D7S_02140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D7S_02141	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D7S_02144	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D7S_02145	COG1177	transmembrane transport
D7S_02146	COG1176	ABC-type spermidine putrescine transport system, permease component I
D7S_02147	COG3842	ATPase activity
D7S_02149	COG3008	intermembrane lipid transfer
D7S_02150	COG2995	paraquat-inducible protein a
D7S_02151	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D7S_02153	COG0793	Belongs to the peptidase S41A family
D7S_02154	COG2989	Protein conserved in bacteria
D7S_02155	COG3108	Peptidase M15
D7S_02156	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D7S_02158	COG0567	Dehydrogenase, E1 component
D7S_02159	COG0508	dehydrogenase complex catalyzes the overall conversion of
D7S_02162	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D7S_02164	COG3383	formate dehydrogenase (NAD+) activity
D7S_02165	COG3383	formate dehydrogenase (NAD+) activity
D7S_02167	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D7S_02169	COG3260	NADH ubiquinone oxidoreductase 20
D7S_02170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D7S_02171	COG3261	NADH dehydrogenase
D7S_02171	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D7S_02172	COG0651	ATP synthesis coupled electron transport
D7S_02173	COG4237	Hydrogenase 4 membrane
D7S_02174	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D7S_02175	COG0650	Formate hydrogenlyase subunit 4
D7S_02176	COG0651	ATP synthesis coupled electron transport
D7S_02177	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D7S_02178	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D7S_02180	COG2864	formate dehydrogenase
D7S_02181	COG0437	4 iron, 4 sulfur cluster binding
D7S_02185	COG1609	Transcriptional regulator
D7S_02186	COG3265	gluconokinase activity
D7S_02187	COG2610	gluconate transmembrane transporter activity
D7S_02188	COG0210	DNA helicase
D7S_02189	COG1793	dna ligase
D7S_02191	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D7S_02192	COG4115	mRNA cleavage
D7S_02193	COG2161	toxin-antitoxin pair type II binding
D7S_02194	COG5039	Polysaccharide pyruvyl transferase
D7S_02196	COG3306	glycosyltransferase involved in LPS biosynthesis
D7S_02198	COG1216	Glycosyl transferase, family 2
D7S_02199	COG1216	Glycosyl transferase, family 2
D7S_02200	COG2951	lytic endotransglycosylase activity
D7S_02201	COG0708	Exodeoxyribonuclease III
D7S_02202	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
D7S_02203	COG1088	dTDP-glucose 4,6-dehydratase activity
D7S_02205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D7S_02206	COG0671	phosphoesterase, PA-phosphatase related
D7S_02207	COG1940	carbohydrate kinase activity
D7S_02211	COG0515	serine threonine protein kinase
D7S_02213	COG1946	Acyl-CoA thioesterase
D7S_02214	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D7S_02215	COG4988	ABC transporter
D7S_02216	COG0492	ferredoxin-NADP+ reductase activity
D7S_02217	COG3118	belongs to the thioredoxin family
D7S_02218	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D7S_02219	COG0303	'Molybdopterin
D7S_02221	COG2027	D-alanyl-D-alanine carboxypeptidase
D7S_02222	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D7S_02223	COG1534	Rna-binding protein
D7S_02224	COG3657	addiction module killer protein
D7S_02225	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D7S_02226	COG0307	riboflavin synthase, alpha
D7S_02228	COG4774	siderophore transport
D7S_02229	COG4178	(ABC) transporter
D7S_02230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D7S_02231	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D7S_02233	COG3102	Protein conserved in bacteria
D7S_02234	COG3133	Outer membrane lipoprotein
D7S_02235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D7S_02236	COG2890	protein-(glutamine-N5) methyltransferase activity
D7S_02238	COG0791	NLP P60 protein
D7S_02239	COG3100	YcgL domain-containing protein
D7S_02242	COG2062	phosphohistidine phosphatase, SixA
D7S_02244	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D7S_02252	COG2932	Transcriptional regulator
D7S_02254	COG0517	IMP dehydrogenase activity
D7S_02254	COG0516	GMP reductase activity
D7S_02255	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D7S_02255	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D7S_02261	COG4172	Belongs to the ABC transporter superfamily
D7S_02262	COG4172	Belongs to the ABC transporter superfamily
D7S_02263	COG4171	peptide transport system, permease
D7S_02264	COG4168	peptide transport system, permease
D7S_02267	COG3106	COG3106 Predicted ATPase
D7S_02270	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D7S_02272	COG1923	regulation of RNA biosynthetic process
D7S_02275	COG0860	N-Acetylmuramoyl-L-alanine amidase
D7S_02275	COG1388	LysM domain
D7S_02276	COG0802	atpase or kinase
D7S_02281	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D7S_02283	COG2194	sulfuric ester hydrolase activity
D7S_02292	COG2337	Toxic component of a toxin-antitoxin (TA) module
D7S_02295	COG3021	interspecies interaction between organisms
D7S_02313	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D7S_02314	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D7S_02315	COG2190	(PTS) system
D7S_02316	COG0339	signal peptide processing
D7S_02317	COG2832	Protein of unknown function (DUF454)
D7S_02327	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D7S_02329	COG0512	Glutamine amidotransferase of anthranilate synthase
D7S_02330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D7S_02340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D7S_02342	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D7S_02345	COG3684	Belongs to the aldolase LacD family
D7S_02347	COG1063	alcohol dehydrogenase
D7S_02348	COG1349	DNA-binding transcription factor activity
D7S_02350	COG0142	geranyltranstransferase activity
D7S_02353	COG0285	dihydrofolate synthase activity
D7S_02354	COG0406	alpha-ribazole phosphatase activity
D7S_02355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D7S_02356	COG2431	L-lysine efflux transmembrane transporter activity
D7S_02357	COG0564	pseudouridine synthase activity
D7S_02360	COG2824	Alkylphosphonate utilization operon protein PhnA
D7S_02362	COG1538	Outer membrane efflux protein
D7S_02363	COG1136	(ABC) transporter
D7S_02363	COG0577	efflux transmembrane transporter activity
D7S_02364	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D7S_02376	COG4591	ABC-type transport system involved in lipoprotein release permease component
D7S_02378	COG4591	ABC-type transport system involved in lipoprotein release permease component
D7S_02379	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D7S_02381	COG0305	Participates in initiation and elongation during chromosome replication
D7S_02383	COG0166	Belongs to the GPI family
D7S_02385	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D7S_02387	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D7S_02388	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D7S_02389	COG1280	lysine exporter protein (LysE YggA)
D7S_02391	COG0633	Ferredoxin
D7S_02393	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_02396	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D7S_02399	COG1840	ABC-type Fe3 transport system, periplasmic component
D7S_02402	COG0366	Alpha amylase catalytic
D7S_02403	COG3833	ABC-type maltose transport systems, permease component
D7S_02405	COG2182	Extracellular solute-binding protein
D7S_02406	COG3842	ATPase activity
D7S_02407	COG4580	involved in the transport of maltose and maltodextrins
D7S_02410	COG0676	glucose-6-phosphate 1-epimerase activity
D7S_02412	COG1199	ATP-dependent helicase activity
D7S_02413	COG1214	PFAM Peptidase M22, glycoprotease
D7S_02414	COG3065	identical protein binding
D7S_02417	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D7S_02418	COG1858	cytochrome C peroxidase
D7S_02423	COG0330	HflC and HflK could
D7S_02425	COG2249	NAD(P)H dehydrogenase (quinone) activity
D7S_02426	COG3381	protein complex oligomerization
D7S_02427	COG1560	Kdo2-lipid A biosynthetic process
D7S_02428	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D7S_02428	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D7S_02429	COG2166	iron-sulfur cluster assembly
D7S_02430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D7S_02431	COG1525	nuclease
D7S_02434	COG4774	siderophore transport
D7S_02438	COG1120	ATPase activity
D7S_02441	COG3585	molybdate ion transport
D7S_02443	COG1120	ATPase activity
D7S_02460	COG4771	TonB-dependent receptor
D7S_02460	COG1629	transport
D7S_02470	COG0791	NLP P60 protein
D7S_02500	COG3098	single-species biofilm formation
D7S_02540	COG0745	RESPONSE REGULATOR receiver
D7S_02545	COG0745	RESPONSE REGULATOR receiver
D7S_02580	COG1122	ATPase activity
D7S_02585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D7S_02635	COG3177	Filamentation induced by cAMP protein fic
D7S_02700	COG2801	Transposase and inactivated derivatives
D7S_02705	COG2351	hydroxyisourate hydrolase activity
D7S_02740	COG3550	peptidyl-serine autophosphorylation
D7S_02785	COG0346	lactoylglutathione lyase activity
D7S_02870	COG1841	ribosomal large subunit assembly
D7S_02875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D7S_02910	COG2267	carboxylic ester hydrolase activity
D7S_02970	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D7S_03000	COG1561	YicC-like family, N-terminal region
D7S_03005	COG1381	Involved in DNA repair and RecF pathway recombination
D7S_03050	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D7S_03055	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
D7S_03065	COG3501	Rhs element vgr protein
D7S_03085	COG0702	epimerase
D7S_03140	COG2207	Transcriptional regulator
D7S_03140	COG1609	Transcriptional regulator
D7S_03150	COG0243	molybdopterin cofactor binding
D7S_03170	COG0243	molybdopterin cofactor binding
D7S_03240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D7S_03260	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D7S_03260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D7S_03340	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D7S_03345	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D7S_03345	COG0237	dephospho-CoA kinase activity
D7S_03450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D7S_03450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D7S_03475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D7S_03535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D7S_03540	COG3468	outer membrane autotransporter barrel domain protein
D7S_03540	COG3266	domain, Protein
D7S_03560	COG3676	manually curated
D7S_03680	COG4166	transmembrane transport
D7S_03755	COG3842	ATPase activity
D7S_03760	COG0318	PFAM AMP-dependent synthetase and ligase
D7S_03765	COG0318	PFAM AMP-dependent synthetase and ligase