locus-tag	class	description
FXN59_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN59_00010	COG0592	DNA-directed DNA polymerase activity
FXN59_00020	COG2226	methyltransferase
FXN59_00035	COG0281	malic enzyme
FXN59_00040	COG2081	HI0933 family
FXN59_00045	COG3088	subunit of a heme lyase
FXN59_00045	COG4235	cytochrome complex assembly
FXN59_00050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_00055	COG1138	Cytochrome C-type biogenesis protein
FXN59_00100	COG1138	Cytochrome C-type biogenesis protein
FXN59_00110	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_00115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_00120	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FXN59_00125	COG4133	protoheme IX ABC transporter activity
FXN59_00130	COG2814	Major facilitator Superfamily
FXN59_00165	COG2801	Transposase and inactivated derivatives
FXN59_00180	COG2267	carboxylic ester hydrolase activity
FXN59_00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FXN59_00195	COG0436	Aminotransferase
FXN59_00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FXN59_00215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FXN59_00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FXN59_00230	COG1652	LysM domain
FXN59_00235	COG2321	neutral zinc metallopeptidase
FXN59_00250	COG0281	malic enzyme
FXN59_00250	COG0280	phosphate acetyltransferase
FXN59_00280	COG2801	Transposase and inactivated derivatives
FXN59_00285	COG3091	SprT-like family
FXN59_00290	COG0814	amino acid
FXN59_00295	COG1760	l-serine dehydratase
FXN59_00300	COG0252	asparaginase activity
FXN59_00315	COG1426	Protein conserved in bacteria
FXN59_00330	COG2976	Protein conserved in bacteria
FXN59_00340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FXN59_00345	COG2233	PERMEase
FXN59_00350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FXN59_00355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN59_00360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FXN59_00370	COG0659	secondary active sulfate transmembrane transporter activity
FXN59_00390	COG2186	Transcriptional regulator
FXN59_00405	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FXN59_00415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN59_00420	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_00430	COG0800	Aldolase
FXN59_00445	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FXN59_00450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN59_00460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FXN59_00465	COG1555	photosystem II stabilization
FXN59_00475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FXN59_00495	COG0196	riboflavin kinase activity
FXN59_00500	COG0728	peptidoglycan biosynthetic process
FXN59_00515	COG0560	Phosphoserine phosphatase
FXN59_00525	COG0193	aminoacyl-tRNA hydrolase activity
FXN59_00530	COG0012	GTP binding
FXN59_00540	COG1573	uracil-dna glycosylase
FXN59_00545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FXN59_00555	COG3115	cell septum assembly
FXN59_00575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FXN59_00580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FXN59_00590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXN59_00620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FXN59_00625	COG0255	Belongs to the universal ribosomal protein uL29 family
FXN59_00630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FXN59_00635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FXN59_00640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FXN59_00645	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FXN59_00650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FXN59_00655	COG0089	rRNA binding
FXN59_00660	COG0088	Forms part of the polypeptide exit tunnel
FXN59_00665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FXN59_00670	COG0051	transcription antitermination factor activity, RNA binding
FXN59_00675	COG0583	DNA-binding transcription factor activity
FXN59_00680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FXN59_00695	COG0183	Belongs to the thiolase family
FXN59_00705	COG1288	antiporter activity
FXN59_00710	COG0549	Belongs to the carbamate kinase family
FXN59_00715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FXN59_00720	COG0038	chloride channel
FXN59_00725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FXN59_00735	COG1522	sequence-specific DNA binding
FXN59_00740	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FXN59_00750	COG1393	Belongs to the ArsC family
FXN59_00760	COG3036	rescue of stalled ribosome
FXN59_00765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FXN59_00770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FXN59_00775	COG2841	Protein conserved in bacteria
FXN59_00790	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN59_00800	COG0569	domain protein
FXN59_00805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FXN59_00805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FXN59_00840	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FXN59_00845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FXN59_00855	COG1739	Uncharacterized protein family UPF0029
FXN59_00870	COG3172	ATPase kinase involved in NAD metabolism
FXN59_00875	COG2129	metallophosphoesterase
FXN59_00880	COG0814	amino acid
FXN59_00895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FXN59_00915	COG0201	protein transport
FXN59_00925	COG1841	ribosomal large subunit assembly
FXN59_00935	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FXN59_00945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FXN59_00955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FXN59_00965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FXN59_00980	COG0805	protein transport
FXN59_00985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN59_00990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FXN59_01000	COG3293	Transposase
FXN59_01020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FXN59_01025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FXN59_01030	COG1011	Hydrolase
FXN59_01035	COG0494	nUDIX hydrolase
FXN59_01040	COG1917	Cupin 2, conserved barrel domain protein
FXN59_01040	COG4977	sequence-specific DNA binding
FXN59_01045	COG3059	membrane
FXN59_01050	COG1297	OPT oligopeptide transporter protein
FXN59_01060	COG1218	3'(2'),5'-bisphosphate nucleotidase
FXN59_01065	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FXN59_01070	COG0363	glucosamine-6-phosphate deaminase activity
FXN59_01090	COG0762	integral membrane protein
FXN59_01100	COG0778	Nitroreductase
FXN59_01105	COG1368	sulfuric ester hydrolase activity
FXN59_01125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FXN59_01145	COG0006	proline dipeptidase activity
FXN59_01175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FXN59_01180	COG1792	Involved in formation and maintenance of cell shape
FXN59_01185	COG1077	Cell shape determining protein MreB Mrl
FXN59_01190	COG0557	exoribonuclease II activity
FXN59_01200	COG2271	Major facilitator Superfamily
FXN59_01205	COG0584	glycerophosphoryl diester phosphodiesterase
FXN59_01210	COG0758	DNA mediated transformation
FXN59_01245	COG1132	(ABC) transporter
FXN59_01250	COG4977	sequence-specific DNA binding
FXN59_01250	COG1917	Cupin 2, conserved barrel domain protein
FXN59_01255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FXN59_01260	COG0859	PFAM glycosyl transferase family 9
FXN59_01275	COG1519	Transferase
FXN59_01280	COG0463	Glycosyl transferase, family 2
FXN59_01295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FXN59_01300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FXN59_01305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN59_01310	COG3719	Belongs to the RNase T2 family
FXN59_01320	COG0191	fructose-bisphosphate aldolase activity
FXN59_01325	COG3307	-O-antigen
FXN59_01330	COG2267	carboxylic ester hydrolase activity
FXN59_01340	COG0561	phosphatase activity
FXN59_01345	COG3293	Transposase
FXN59_01360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN59_01375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FXN59_01390	COG0583	DNA-binding transcription factor activity
FXN59_01395	COG2962	Rard protein
FXN59_01410	COG0551	DNA topoisomerase type I activity
FXN59_01435	COG0705	Rhomboid family
FXN59_01440	COG1349	DNA-binding transcription factor activity
FXN59_01455	COG4178	(ABC) transporter
FXN59_01470	COG0233	cytoplasmic translational termination
FXN59_01475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FXN59_01485	COG0575	Belongs to the CDS family
FXN59_01500	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FXN59_01510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN59_01520	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FXN59_01530	COG0490	domain, Protein
FXN59_01530	COG0471	metal ion transport
FXN59_01535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN59_01545	COG4589	Belongs to the CDS family
FXN59_01550	COG0521	Mo-molybdopterin cofactor biosynthetic process
FXN59_01565	COG3276	selenocysteine insertion sequence binding
FXN59_01570	COG1921	L-seryl-tRNASec selenium transferase activity
FXN59_01575	COG0442	prolyl-tRNA aminoacylation
FXN59_01590	COG1595	DNA-templated transcription, initiation
FXN59_01595	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FXN59_01600	COG3026	antisigma factor binding
FXN59_01605	COG3086	response to oxidative stress
FXN59_01610	COG1763	Mo-molybdopterin cofactor biosynthetic process
FXN59_01615	COG0300	oxidoreductase activity
FXN59_01620	COG2195	Cleaves the N-terminal amino acid of tripeptides
FXN59_01630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FXN59_01635	COG2818	Glycosylase
FXN59_01640	COG3293	Transposase
FXN59_01645	COG3477	response to acidic pH
FXN59_01650	COG0019	diaminopimelate decarboxylase activity
FXN59_01665	COG0514	ATP-dependent DNA helicase (RecQ)
FXN59_01670	COG0187	DNA topoisomerase II activity
FXN59_01675	COG1072	(Pantothenic acid kinase))
FXN59_01700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FXN59_01705	COG1879	ABC-type sugar transport system periplasmic component
FXN59_01710	COG1129	ABC transporter
FXN59_01725	COG2183	response to ionizing radiation
FXN59_01730	COG0583	DNA-binding transcription factor activity
FXN59_01745	COG2183	response to ionizing radiation
FXN59_01750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN59_01760	COG1595	DNA-templated transcription, initiation
FXN59_01770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FXN59_01775	COG3071	HemY protein
FXN59_01780	COG2959	enzyme of heme biosynthesis
FXN59_01790	COG0181	hydroxymethylbilane synthase activity
FXN59_01800	COG2197	response regulator
FXN59_01805	COG0729	surface antigen
FXN59_01810	COG2911	Protein conserved in bacteria
FXN59_01815	COG0248	Ppx GppA phosphatase
FXN59_01835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FXN59_01840	COG3068	Protein conserved in bacteria
FXN59_01850	COG1349	DNA-binding transcription factor activity
FXN59_01855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FXN59_01865	COG0433	COG0433 Predicted ATPase
FXN59_01870	COG2258	MOSC domain
FXN59_01875	COG3012	SEC-C Motif Domain Protein
FXN59_01890	COG0786	glutamate:sodium symporter activity
FXN59_01895	COG2205	protein histidine kinase activity
FXN59_01900	COG0745	RESPONSE REGULATOR receiver
FXN59_01905	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FXN59_01915	COG3082	Protein of unknown function (DUF1414)
FXN59_01920	COG3083	sulfuric ester hydrolase activity
FXN59_01925	COG0402	S-adenosylhomocysteine deaminase activity
FXN59_01930	COG3956	TIGRFAM MazG family protein
FXN59_01945	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FXN59_01955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FXN59_01960	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
FXN59_01965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FXN59_01980	COG0148	phosphopyruvate hydratase activity
FXN59_01995	COG2991	Protein conserved in bacteria
FXN59_02000	COG1477	protein flavinylation
FXN59_02005	COG2871	sodium ion transport
FXN59_02010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_02015	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_02020	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FXN59_02040	COG3056	Lipoprotein
FXN59_02060	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FXN59_02065	COG1194	a g-specific adenine glycosylase
FXN59_02075	COG3171	Protein conserved in bacteria
FXN59_02080	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_02085	COG1178	ABC-type Fe3 transport system permease component
FXN59_02090	COG3842	ATPase activity
FXN59_02105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FXN59_02115	COG1561	YicC-like family, N-terminal region
FXN59_02120	COG0354	folic acid binding
FXN59_02140	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FXN59_02145	COG1381	Involved in DNA repair and RecF pathway recombination
FXN59_02150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FXN59_02155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN59_02160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FXN59_02170	COG0500	methyltransferase
FXN59_02175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FXN59_02180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_02185	COG1309	transcriptional regulator
FXN59_02190	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_02200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FXN59_02215	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_02225	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_02245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FXN59_02260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FXN59_02270	COG1309	transcriptional regulator
FXN59_02285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN59_02290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FXN59_02295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FXN59_02300	COG4972	Pilus assembly protein
FXN59_02330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FXN59_02410	COG3293	Transposase
FXN59_02430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FXN59_02435	COG0789	Transcriptional regulator
FXN59_02440	COG4701	Protein of unknown function (DUF721)
FXN59_02455	COG0494	nUDIX hydrolase
FXN59_02460	COG1466	dna polymerase III delta subunit
FXN59_02465	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FXN59_02480	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN59_02485	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
FXN59_02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FXN59_02495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FXN59_02500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FXN59_02520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FXN59_02530	COG4221	oxidoreductase activity
FXN59_02535	COG3293	Transposase
FXN59_02540	COG0789	Transcriptional regulator
FXN59_02545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FXN59_02550	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FXN59_02560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FXN59_02565	COG4137	Cytochrome C assembly protein
FXN59_02570	COG4536	flavin adenine dinucleotide binding
FXN59_02575	COG0811	peptide transport
FXN59_02580	COG0848	biopolymer transport protein
FXN59_02590	COG4783	chaperone-mediated protein folding
FXN59_02600	COG0814	amino acid
FXN59_02635	COG0747	negative chemotaxis
FXN59_02640	COG2853	Lipoprotein
FXN59_02675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FXN59_02680	COG3610	response to peptide
FXN59_02690	COG3293	Transposase
FXN59_02705	COG0688	phosphatidylethanolamine metabolic process
FXN59_02710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FXN59_02720	COG2830	Protein of unknown function (DUF452)
FXN59_02725	COG0500	methyltransferase
FXN59_02735	COG1399	metal-binding, possibly nucleic acid-binding protein
FXN59_02740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FXN59_02745	COG0416	fatty acid biosynthetic process
FXN59_02755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FXN59_02760	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_02775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FXN59_02780	COG0513	Belongs to the DEAD box helicase family
FXN59_02785	COG0799	negative regulation of ribosome biogenesis
FXN59_02795	COG0768	penicillin binding
FXN59_02800	COG0772	Belongs to the SEDS family
FXN59_02805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_02805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FXN59_02810	COG1686	Belongs to the peptidase S11 family
FXN59_02840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN59_02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN59_02850	COG0765	amino acid transport
FXN59_02855	COG1126	abc transporter atp-binding protein
FXN59_02860	COG2168	tRNA wobble position uridine thiolation
FXN59_02870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN59_02875	COG2964	Protein conserved in bacteria
FXN59_02880	COG0545	Peptidyl-prolyl cis-trans isomerase
FXN59_02890	COG0678	peroxiredoxin activity
FXN59_02890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN59_02895	COG0583	DNA-binding transcription factor activity
FXN59_02900	COG1309	transcriptional regulator
FXN59_02905	COG1132	(ABC) transporter
FXN59_02910	COG4988	ABC transporter
FXN59_02915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN59_02920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FXN59_02925	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FXN59_02935	COG1045	serine acetyltransferase
FXN59_02945	COG1494	fructose-1,6-bisphosphatase
FXN59_02955	COG0716	FMN binding
FXN59_02965	COG0702	epimerase
FXN59_02970	COG1733	regulation of RNA biosynthetic process
FXN59_02980	COG3312	ion transport
FXN59_03000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FXN59_03010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FXN59_03025	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN59_03035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FXN59_03055	COG1349	DNA-binding transcription factor activity
FXN59_03095	COG0513	Belongs to the DEAD box helicase family
FXN59_03105	COG3201	nicotinamide mononucleotide transporter
FXN59_03115	COG3501	Rhs element vgr protein
FXN59_03120	COG3078	GTPase activator activity
FXN59_03130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FXN59_03135	COG0456	acetyltransferase
FXN59_03145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FXN59_03170	COG0511	ligase activity, forming carbon-carbon bonds
FXN59_03175	COG0439	Biotin carboxylase
FXN59_03180	COG3293	Transposase
FXN59_03195	COG3924	membrane
FXN59_03200	COG4145	pantothenate transmembrane transporter activity
FXN59_03235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FXN59_03240	COG1115	amino acid carrier protein
FXN59_03250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN59_03255	COG0237	dephospho-CoA kinase activity
FXN59_03255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FXN59_03295	COG3161	chorismate lyase activity
FXN59_03305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FXN59_03310	COG1758	RNA polymerase activity
FXN59_03320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FXN59_03355	COG2801	Transposase and inactivated derivatives
FXN59_03375	COG2271	Major facilitator Superfamily
FXN59_03385	COG1215	transferase activity, transferring glycosyl groups
FXN59_03390	COG0726	polysaccharide deacetylase
FXN59_03390	COG1649	PFAM Uncharacterised BCR, COG1649
FXN59_03405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FXN59_03410	COG0561	phosphatase activity
FXN59_03415	COG3716	PTS system mannose fructose sorbose family IID component
FXN59_03420	COG3715	PTS system
FXN59_03425	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_03425	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_03430	COG0742	ribosomal rna small subunit methyltransferase
FXN59_03435	COG0552	protein localization to endoplasmic reticulum
FXN59_03440	COG2884	Cell division ATP-binding protein ftsE
FXN59_03445	COG2177	Part of the ABC transporter FtsEX involved in
FXN59_03460	COG3293	Transposase
FXN59_03480	COG1720	tRNA m6t6A37 methyltransferase activity
FXN59_03485	COG1575	Belongs to the MenA family. Type 1 subfamily
FXN59_03495	COG3293	Transposase
FXN59_03500	COG0471	metal ion transport
FXN59_03505	COG3028	Belongs to the UPF0307 family
FXN59_03510	COG0312	modulator of DNA gyrase
FXN59_03515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FXN59_03520	COG1929	Belongs to the glycerate kinase type-1 family
FXN59_03535	COG2801	Transposase and inactivated derivatives
FXN59_03545	COG0513	Belongs to the DEAD box helicase family
FXN59_03550	COG4785	May be involved in cell division
FXN59_03560	COG2731	YhcH YjgK YiaL family protein
FXN59_03565	COG3023	N-Acetylmuramoyl-L-alanine amidase
FXN59_03570	COG4969	Belongs to the N-Me-Phe pilin family
FXN59_03615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FXN59_03635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FXN59_03640	COG0222	ribosome binding
FXN59_03655	COG2932	Transcriptional regulator
FXN59_03675	COG0789	Transcriptional regulator
FXN59_03680	COG2608	mercury ion transmembrane transporter activity
FXN59_03685	COG2217	Heavy metal translocating P-type atpase
FXN59_03690	COG3739	integral membrane protein
FXN59_03710	COG0740	serine-type endopeptidase activity
FXN59_03715	COG2194	sulfuric ester hydrolase activity
FXN59_03720	COG2918	glutathione biosynthetic process
FXN59_03720	COG1181	Belongs to the D-alanine--D-alanine ligase family
FXN59_03775	COG0459	protein refolding
FXN59_03780	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FXN59_03790	COG1027	Aspartate ammonia-lyase
FXN59_03795	COG0859	PFAM glycosyl transferase family 9
FXN59_03810	COG3716	PTS system mannose fructose sorbose family IID component
FXN59_03815	COG3715	PTS system
FXN59_03820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_03820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_03825	COG2814	Major facilitator Superfamily
FXN59_03830	COG0662	Cupin 2, conserved barrel domain protein
FXN59_03830	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FXN59_03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_03860	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FXN59_03870	COG0297	glycogen (starch) synthase activity
FXN59_03880	COG1609	Transcriptional regulator
FXN59_03880	COG2207	Transcriptional regulator
FXN59_03885	COG1757	Na H antiporter
FXN59_03890	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FXN59_03895	COG4214	carbohydrate transport
FXN59_03900	COG1129	ABC transporter
FXN59_03905	COG4213	ABC transporter substrate-binding protein
FXN59_03910	COG2115	Belongs to the xylose isomerase family
FXN59_03915	COG1070	Carbohydrate kinase
FXN59_03935	COG3070	regulator of competence-specific genes
FXN59_03940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FXN59_03950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FXN59_03955	COG3850	Histidine kinase
FXN59_03960	COG3062	negative regulation of establishment of protein localization
FXN59_03965	COG0243	molybdopterin cofactor binding
FXN59_03970	COG0437	4 iron, 4 sulfur cluster binding
FXN59_03975	COG0348	domain, Protein
FXN59_03980	COG3043	anaerobic respiration
FXN59_03985	COG3005	denitrification pathway
FXN59_03990	COG0754	glutathionylspermidine amidase activity
FXN59_03995	COG0859	PFAM glycosyl transferase family 9
FXN59_04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_04015	COG0737	Belongs to the 5'-nucleotidase family
FXN59_04035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_04040	COG1028	Short-chain dehydrogenase reductase Sdr
FXN59_04050	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_04105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FXN59_04130	COG1011	Hydrolase
FXN59_04140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FXN59_04145	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FXN59_04165	COG1596	polysaccharide export
FXN59_04165	COG1555	photosystem II stabilization
FXN59_04170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN59_04175	COG0561	phosphatase activity
FXN59_04180	COG1040	competence protein
FXN59_04190	COG0140	phosphoribosyl-ATP diphosphatase activity
FXN59_04190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FXN59_04195	COG1114	Component of the transport system for branched-chain amino acids
FXN59_04220	COG4545	Glutaredoxin-related protein
FXN59_04230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FXN59_04230	COG2221	Nitrite and sulphite reductase 4Fe-4S
FXN59_04235	COG3381	protein complex oligomerization
FXN59_04240	COG3302	dmso reductase anchor subunit
FXN59_04245	COG0437	4 iron, 4 sulfur cluster binding
FXN59_04250	COG0243	molybdopterin cofactor binding
FXN59_04260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN59_04260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FXN59_04270	COG5645	(Lipo)protein
FXN59_04275	COG0210	DNA helicase
FXN59_04305	COG0110	maltose O-acetyltransferase activity
FXN59_04320	COG3293	Transposase
FXN59_04360	COG2095	MarC family integral membrane protein
FXN59_04370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FXN59_04375	COG2137	regulation of response to DNA damage stimulus
FXN59_04380	COG0251	oxidation-reduction process
FXN59_04390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FXN59_04430	COG2369	cell adhesion
FXN59_04455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FXN59_04460	COG0084	hydrolase, TatD family'
FXN59_04465	COG0602	queuosine metabolic process
FXN59_04470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN59_04470	COG1328	CTP reductase activity
FXN59_04485	COG1022	Amp-dependent synthetase and ligase
FXN59_04490	COG0587	DNA-directed DNA polymerase activity
FXN59_04505	COG0753	catalase activity
FXN59_04510	COG3293	Transposase
FXN59_04515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FXN59_04520	COG0165	Argininosuccinate lyase
FXN59_04555	COG0582	viral genome integration into host DNA
FXN59_04620	COG1598	PFAM Uncharacterised protein family UPF0150
FXN59_04635	COG3293	Transposase
FXN59_04655	COG1869	D-ribose catabolic process
FXN59_04665	COG0730	response to heat
FXN59_04675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FXN59_04685	COG0590	tRNA wobble adenosine to inosine editing
FXN59_04715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FXN59_04720	COG4942	peptidase
FXN59_04725	COG2861	carbohydrate metabolic process
FXN59_04730	COG0606	chelatase, subunit chli
FXN59_04760	COG3293	Transposase
FXN59_04835	COG3293	Transposase
FXN59_04850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FXN59_04880	COG2990	Protein conserved in bacteria
FXN59_04885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FXN59_04905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FXN59_04990	COG4964	Belongs to the GSP D family
FXN59_05020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FXN59_05030	COG1444	tRNA N-acetyltransferase activity
FXN59_05035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FXN59_05045	COG1126	abc transporter atp-binding protein
FXN59_05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FXN59_05055	COG4215	(ABC) transporter
FXN59_05060	COG4160	amino acid transport
FXN59_05065	COG1966	Carbon starvation protein
FXN59_05080	COG3116	cell division
FXN59_05085	COG0768	penicillin binding
FXN59_05095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FXN59_05105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FXN59_05115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FXN59_05130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FXN59_05135	COG0849	cell division
FXN59_05140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FXN59_05150	COG0077	Prephenate dehydratase
FXN59_05150	COG1605	Chorismate mutase
FXN59_05155	COG0326	Molecular chaperone. Has ATPase activity
FXN59_05160	COG1393	Belongs to the ArsC family
FXN59_05170	COG1876	peptidase activity
FXN59_05175	COG0494	nUDIX hydrolase
FXN59_05180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FXN59_05225	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FXN59_05235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FXN59_05240	COG1053	succinate dehydrogenase
FXN59_05255	COG1120	ATPase activity
FXN59_05260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_05270	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FXN59_05275	COG1408	metallophosphoesterase
FXN59_05285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FXN59_05290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FXN59_05325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN59_05335	COG0741	lytic transglycosylase activity
FXN59_05340	COG2350	Protein conserved in bacteria
FXN59_05345	COG1607	acyl-coa hydrolase
FXN59_05350	COG2917	probably involved in intracellular septation
FXN59_05370	COG0497	DNA recombination
FXN59_05380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FXN59_05390	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FXN59_05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FXN59_05395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FXN59_05400	COG0784	Response regulator, receiver
FXN59_05400	COG2198	Histidine kinase
FXN59_05400	COG5002	protein histidine kinase activity
FXN59_05405	COG3293	Transposase
FXN59_05420	COG1879	ABC-type sugar transport system periplasmic component
FXN59_05425	COG1609	Transcriptional regulator
FXN59_05430	COG1085	galactose-1-phosphate uridylyltransferase
FXN59_05435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FXN59_05440	COG2017	converts alpha-aldose to the beta-anomer
FXN59_05455	COG0471	metal ion transport
FXN59_05460	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FXN59_05460	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
FXN59_05465	COG3051	citrate lyase alpha subunit
FXN59_05470	COG2301	Belongs to the HpcH HpaI aldolase family
FXN59_05480	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FXN59_05490	COG4535	Mg2 and Co2 transporter CorC
FXN59_05510	COG0105	UTP biosynthetic process
FXN59_05530	COG1388	LysM domain
FXN59_05530	COG4942	peptidase
FXN59_05540	COG1238	metal cluster binding
FXN59_05570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FXN59_05660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN59_05670	COG0733	neurotransmitter:sodium symporter activity
FXN59_05680	COG1285	pathogenesis
FXN59_05740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN59_05740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FXN59_05740	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FXN59_05745	COG1105	Belongs to the carbohydrate kinase PfkB family
FXN59_05750	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_05750	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_05760	COG0746	molybdenum cofactor guanylyltransferase activity
FXN59_05765	COG3084	Protein conserved in bacteria
FXN59_05770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_05775	COG3085	chromosome segregation
FXN59_05825	COG0561	phosphatase activity
FXN59_05870	COG1349	DNA-binding transcription factor activity
FXN59_05875	COG0347	Belongs to the P(II) protein family
FXN59_05880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FXN59_05885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FXN59_05890	COG0470	DNA polymerase III
FXN59_05895	COG0084	hydrolase, TatD family'
FXN59_05905	COG1253	flavin adenine dinucleotide binding
FXN59_05925	COG1263	PTS System
FXN59_05925	COG2190	(PTS) system
FXN59_05925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FXN59_05930	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FXN59_05940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FXN59_05945	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FXN59_05955	COG1737	Transcriptional regulator
FXN59_05960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN59_05965	COG0363	glucosamine-6-phosphate deaminase activity
FXN59_05970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FXN59_05975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FXN59_05995	COG3293	Transposase
FXN59_06020	COG2363	Small membrane protein
FXN59_06025	COG1643	Atp-dependent helicase
FXN59_06045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FXN59_06055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_06060	COG0577	efflux transmembrane transporter activity
FXN59_06060	COG1136	(ABC) transporter
FXN59_06070	COG0577	efflux transmembrane transporter activity
FXN59_06070	COG1136	(ABC) transporter
FXN59_06085	COG0672	)-iron permease
FXN59_06090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FXN59_06100	COG0316	Belongs to the HesB IscA family
FXN59_06105	COG0024	Methionine aminopeptidase
FXN59_06115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FXN59_06120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FXN59_06165	COG4172	Belongs to the ABC transporter superfamily
FXN59_06170	COG4172	Belongs to the ABC transporter superfamily
FXN59_06175	COG4171	peptide transport system, permease
FXN59_06180	COG4168	peptide transport system, permease
FXN59_06185	COG4166	transmembrane transport
FXN59_06190	COG3106	COG3106 Predicted ATPase
FXN59_06200	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FXN59_06205	COG1923	regulation of RNA biosynthetic process
FXN59_06215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FXN59_06220	COG0860	N-Acetylmuramoyl-L-alanine amidase
FXN59_06220	COG1388	LysM domain
FXN59_06225	COG0802	atpase or kinase
FXN59_06245	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FXN59_06255	COG2194	sulfuric ester hydrolase activity
FXN59_06275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_06280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FXN59_06285	COG2190	(PTS) system
FXN59_06290	COG0339	signal peptide processing
FXN59_06295	COG2832	Protein of unknown function (DUF454)
FXN59_06300	COG4166	transmembrane transport
FXN59_06335	COG3008	intermembrane lipid transfer
FXN59_06340	COG2995	paraquat-inducible protein a
FXN59_06350	COG0793	Belongs to the peptidase S41A family
FXN59_06355	COG2989	Protein conserved in bacteria
FXN59_06360	COG3108	Peptidase M15
FXN59_06365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN59_06370	COG0567	Dehydrogenase, E1 component
FXN59_06375	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN59_06385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FXN59_06515	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FXN59_06525	COG3260	NADH ubiquinone oxidoreductase 20
FXN59_06530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FXN59_06540	COG0651	ATP synthesis coupled electron transport
FXN59_06545	COG4237	Hydrogenase 4 membrane
FXN59_06575	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FXN59_06580	COG2864	formate dehydrogenase
FXN59_06585	COG0437	4 iron, 4 sulfur cluster binding
FXN59_06605	COG1609	Transcriptional regulator
FXN59_06610	COG3265	gluconokinase activity
FXN59_06615	COG2610	gluconate transmembrane transporter activity
FXN59_06620	COG0210	DNA helicase
FXN59_06630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FXN59_06635	COG4115	mRNA cleavage
FXN59_06640	COG2161	toxin-antitoxin pair type II binding
FXN59_06645	COG5039	Polysaccharide pyruvyl transferase
FXN59_06655	COG3293	Transposase
FXN59_06660	COG3306	glycosyltransferase involved in LPS biosynthesis
FXN59_06670	COG1216	Glycosyl transferase, family 2
FXN59_06675	COG1216	Glycosyl transferase, family 2
FXN59_06680	COG2951	lytic endotransglycosylase activity
FXN59_06685	COG0708	Exodeoxyribonuclease III
FXN59_06690	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FXN59_06695	COG1088	dTDP-glucose 4,6-dehydratase activity
FXN59_06705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FXN59_06710	COG0671	phosphoesterase, PA-phosphatase related
FXN59_06730	COG0515	serine threonine protein kinase
FXN59_06735	COG1946	Acyl-CoA thioesterase
FXN59_06745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FXN59_06750	COG4988	ABC transporter
FXN59_06755	COG0492	ferredoxin-NADP+ reductase activity
FXN59_06760	COG3118	belongs to the thioredoxin family
FXN59_06770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FXN59_06775	COG0303	'Molybdopterin
FXN59_06785	COG2027	D-alanyl-D-alanine carboxypeptidase
FXN59_06790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FXN59_06795	COG1534	Rna-binding protein
FXN59_06800	COG3657	addiction module killer protein
FXN59_06805	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN59_06810	COG0307	riboflavin synthase, alpha
FXN59_06820	COG4774	siderophore transport
FXN59_06825	COG4178	(ABC) transporter
FXN59_06830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FXN59_06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FXN59_06845	COG3102	Protein conserved in bacteria
FXN59_06850	COG3133	Outer membrane lipoprotein
FXN59_06855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FXN59_06860	COG2890	protein-(glutamine-N5) methyltransferase activity
FXN59_06870	COG0791	NLP P60 protein
FXN59_06880	COG3100	YcgL domain-containing protein
FXN59_06895	COG2062	phosphohistidine phosphatase, SixA
FXN59_06905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FXN59_06910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FXN59_06920	COG2932	Transcriptional regulator
FXN59_06930	COG0517	IMP dehydrogenase activity
FXN59_06930	COG0516	GMP reductase activity
FXN59_07005	COG0195	Participates in both transcription termination and antitermination
FXN59_07065	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FXN59_07090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FXN59_07095	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FXN59_07120	COG0395	ABC-type sugar transport system, permease component
FXN59_07130	COG0322	excinuclease ABC activity
FXN59_07140	COG2835	tetraacyldisaccharide 4'-kinase activity
FXN59_07145	COG1663	tetraacyldisaccharide 4'-kinase activity
FXN59_07155	COG2333	competence protein COMEC
FXN59_07155	COG0658	competence protein
FXN59_07160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FXN59_07170	COG0617	tRNA 3'-terminal CCA addition
FXN59_07175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FXN59_07185	COG0857	belongs to the CobB CobQ family
FXN59_07185	COG0280	phosphate acetyltransferase
FXN59_07190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FXN59_07195	COG3092	negative regulation of chromosome organization
FXN59_07200	COG1286	toxin biosynthetic process
FXN59_07205	COG1640	4-alpha-glucanotransferase
FXN59_07210	COG0058	SHG alpha-glucan phosphorylase activity
FXN59_07215	COG2909	trisaccharide binding
FXN59_07225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FXN59_07230	COG0508	dehydrogenase complex catalyzes the overall conversion of
FXN59_07235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FXN59_07240	COG0778	Nitroreductase
FXN59_07245	COG0616	signal peptide processing
FXN59_07250	COG1605	Chorismate mutase
FXN59_07250	COG0287	Prephenate dehydrogenase
FXN59_07255	COG0009	L-threonylcarbamoyladenylate synthase
FXN59_07265	COG0583	DNA-binding transcription factor activity
FXN59_07285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FXN59_07290	COG2949	membrane
FXN59_07295	COG1609	Transcriptional regulator
FXN59_07325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FXN59_07340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_07345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FXN59_07350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FXN59_07355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FXN59_07360	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
FXN59_07365	COG0310	cobalt ion transport
FXN59_07370	COG0310	cobalt ion transport
FXN59_07375	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FXN59_07380	COG1122	ATPase activity
FXN59_07390	COG0409	Hydrogenase expression formation protein
FXN59_07440	COG0629	single-stranded DNA binding
FXN59_07460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FXN59_07465	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FXN59_07470	COG0795	lipopolysaccharide-transporting ATPase activity
FXN59_07475	COG0795	lipopolysaccharide-transporting ATPase activity
FXN59_07485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FXN59_07490	COG4149	molybdate abc transporter
FXN59_07495	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN59_07500	COG2005	Transcriptional regulator
FXN59_07505	COG0471	metal ion transport
FXN59_07515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN59_07520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN59_07520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FXN59_07525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FXN59_07535	COG0583	DNA-binding transcription factor activity
FXN59_07540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN59_07555	COG0039	L-malate dehydrogenase activity
FXN59_07560	COG1438	arginine binding
FXN59_07565	COG1090	epimerase
FXN59_07570	COG4657	Part of a membrane complex involved in electron transport
FXN59_07580	COG4656	Part of a membrane complex involved in electron transport
FXN59_07600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FXN59_07605	COG0733	neurotransmitter:sodium symporter activity
FXN59_07610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_07620	COG0739	heme binding
FXN59_07625	COG4604	ABC transporter, ATP-binding protein
FXN59_07630	COG4605	iron ion homeostasis
FXN59_07635	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FXN59_07640	COG4607	ABC-type enterochelin transport system periplasmic component
FXN59_07645	COG0737	Belongs to the 5'-nucleotidase family
FXN59_07660	COG3111	PFAM Bacterial OB fold (BOF) protein
FXN59_07665	COG0745	RESPONSE REGULATOR receiver
FXN59_07670	COG0642	Histidine kinase
FXN59_07675	COG0405	Gamma-glutamyltransferase
FXN59_07690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FXN59_07695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FXN59_07700	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FXN59_07755	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FXN59_07765	COG0583	DNA-binding transcription factor activity
FXN59_07770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FXN59_07775	COG1687	branched-chain amino acid
FXN59_07780	COG0612	Peptidase, M16
FXN59_07785	COG4771	TonB-dependent receptor
FXN59_07790	COG2990	Protein conserved in bacteria
FXN59_07800	COG0539	negative regulation of cytoplasmic translation
FXN59_07805	COG0776	regulation of translation
FXN59_07810	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FXN59_07815	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FXN59_07825	COG0023	Translation Initiation Factor
FXN59_07830	COG3094	Invasion gene expression up-regulator, SirB
FXN59_07835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN59_07840	COG0735	belongs to the Fur family
FXN59_07845	COG0716	FMN binding
FXN59_07855	COG0596	Alpha beta hydrolase
FXN59_07860	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FXN59_07865	COG0318	PFAM AMP-dependent synthetase and ligase
FXN59_07870	COG3264	Mechanosensitive ion channel
FXN59_07870	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN59_07875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FXN59_07880	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FXN59_07885	COG0730	response to heat
FXN59_07890	COG1560	Kdo2-lipid A biosynthetic process
FXN59_07900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FXN59_07910	COG0463	Glycosyl transferase, family 2
FXN59_07925	COG2932	Transcriptional regulator
FXN59_07930	COG3423	Transcriptional regulator
FXN59_07935	COG2801	Transposase and inactivated derivatives
FXN59_07940	COG0251	oxidation-reduction process
FXN59_07955	COG1757	Na H antiporter
FXN59_07960	COG3293	Transposase
FXN59_07965	COG2916	Histone family protein nucleoid-structuring protein H-NS
FXN59_07970	COG0788	formyltetrahydrofolate deformylase activity
FXN59_07980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FXN59_07990	COG3842	ATPase activity
FXN59_07995	COG1178	ABC-type Fe3 transport system permease component
FXN59_08000	COG3842	ATPase activity
FXN59_08030	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FXN59_08035	COG3098	single-species biofilm formation
FXN59_08050	COG1278	Cold shock
FXN59_08060	COG1067	ATP-dependent peptidase activity
FXN59_08065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FXN59_08075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FXN59_08080	COG1074	ATP-dependent DNA helicase activity
FXN59_08085	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FXN59_08105	COG0101	tRNA pseudouridine synthase activity
FXN59_08110	COG2026	Addiction module toxin, RelE StbE family
FXN59_08120	COG0471	metal ion transport
FXN59_08125	COG2315	Protein conserved in bacteria
FXN59_08135	COG3005	denitrification pathway
FXN59_08160	COG3293	Transposase
FXN59_08220	COG1346	cytolysis
FXN59_08235	COG3657	addiction module killer protein
FXN59_08270	COG3293	Transposase
FXN59_08325	COG3423	Transcriptional regulator
FXN59_08330	COG2932	Transcriptional regulator
FXN59_08340	COG0586	Pfam SNARE associated Golgi protein
FXN59_08345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FXN59_08355	COG1686	Belongs to the peptidase S11 family
FXN59_08360	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FXN59_08370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FXN59_08375	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FXN59_08380	COG0697	spore germination
FXN59_08385	COG2925	Exonuclease
FXN59_08395	COG2801	Transposase and inactivated derivatives
FXN59_08400	COG2801	Transposase and inactivated derivatives
FXN59_08525	COG1528	Iron-storage protein
FXN59_08530	COG1528	Iron-storage protein
FXN59_08535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FXN59_08540	COG0589	response to stress
FXN59_08560	COG0613	PHP domain protein
FXN59_08565	COG0167	dihydroorotate dehydrogenase activity
FXN59_08570	COG0308	aminopeptidase N
FXN59_08575	COG1448	Aminotransferase
FXN59_08585	COG3293	Transposase
FXN59_08620	COG0791	NLP P60 protein
FXN59_08635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FXN59_08650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FXN59_08650	COG0517	IMP dehydrogenase activity
FXN59_08655	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FXN59_08660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FXN59_08665	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN59_08670	COG1942	4-Oxalocrotonate Tautomerase
FXN59_08680	COG0135	phosphoribosylanthranilate isomerase activity
FXN59_08680	COG0134	indole-3-glycerol-phosphate synthase activity
FXN59_08695	COG0298	carbon dioxide binding
FXN59_08710	COG3293	Transposase
FXN59_08715	COG3630	sodium ion export across plasma membrane
FXN59_08750	COG4221	oxidoreductase activity
FXN59_08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_08775	COG0469	pyruvate kinase activity
FXN59_08790	COG1879	ABC-type sugar transport system periplasmic component
FXN59_08810	COG2390	Transcriptional regulator
FXN59_08830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FXN59_08835	COG1940	carbohydrate kinase activity
FXN59_08845	COG2969	positive regulation of protein catabolic process
FXN59_08855	COG0314	molybdopterin synthase activity
FXN59_08860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FXN59_08870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FXN59_08920	COG3293	Transposase
FXN59_08930	COG2801	Transposase and inactivated derivatives
FXN59_08955	COG1120	ATPase activity
FXN59_08965	COG3585	molybdate ion transport
FXN59_08990	COG4774	siderophore transport
FXN59_09015	COG2166	iron-sulfur cluster assembly
FXN59_09020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FXN59_09020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FXN59_09025	COG1560	Kdo2-lipid A biosynthetic process
FXN59_09030	COG3381	protein complex oligomerization
FXN59_09035	COG2249	NAD(P)H dehydrogenase (quinone) activity
FXN59_09045	COG0330	HflC and HflK could
FXN59_09070	COG1858	cytochrome C peroxidase
FXN59_09075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FXN59_09080	COG0318	PFAM AMP-dependent synthetase and ligase
FXN59_09085	COG3065	identical protein binding
FXN59_09090	COG1214	PFAM Peptidase M22, glycoprotease
FXN59_09095	COG1199	ATP-dependent helicase activity
FXN59_09100	COG0676	glucose-6-phosphate 1-epimerase activity
FXN59_09110	COG4580	involved in the transport of maltose and maltodextrins
FXN59_09115	COG3842	ATPase activity
FXN59_09120	COG2182	Extracellular solute-binding protein
FXN59_09130	COG3833	ABC-type maltose transport systems, permease component
FXN59_09135	COG0366	Alpha amylase catalytic
FXN59_09140	COG3842	ATPase activity
FXN59_09150	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_09165	COG0732	type I restriction modification DNA specificity domain
FXN59_09185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_09195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FXN59_09205	COG0633	Ferredoxin
FXN59_09220	COG1280	lysine exporter protein (LysE YggA)
FXN59_09225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FXN59_09230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FXN59_09240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FXN59_09245	COG3293	Transposase
FXN59_09255	COG0166	Belongs to the GPI family
FXN59_09265	COG0305	Participates in initiation and elongation during chromosome replication
FXN59_09270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FXN59_09275	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN59_09285	COG4591	ABC-type transport system involved in lipoprotein release permease component
FXN59_09330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_09335	COG1136	(ABC) transporter
FXN59_09335	COG0577	efflux transmembrane transporter activity
FXN59_09340	COG1538	Outer membrane efflux protein
FXN59_09350	COG2824	Alkylphosphonate utilization operon protein PhnA
FXN59_09360	COG0564	pseudouridine synthase activity
FXN59_09365	COG2431	L-lysine efflux transmembrane transporter activity
FXN59_09375	COG0406	alpha-ribazole phosphatase activity
FXN59_09380	COG0285	dihydrofolate synthase activity
FXN59_09395	COG0142	geranyltranstransferase activity
FXN59_09405	COG1349	DNA-binding transcription factor activity
FXN59_09410	COG1063	alcohol dehydrogenase
FXN59_09420	COG3414	Phosphotransferase system galactitol-specific IIB component
FXN59_09425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_09435	COG3684	Belongs to the aldolase LacD family
FXN59_09445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FXN59_09450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FXN59_09500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN59_09505	COG0512	Glutamine amidotransferase of anthranilate synthase
FXN59_09515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FXN59_09585	COG1846	Transcriptional regulator
FXN59_09585	COG1940	carbohydrate kinase activity
FXN59_09595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FXN59_09600	COG2226	methyltransferase
FXN59_09610	COG3293	Transposase
FXN59_09615	COG3422	double-strand break repair
FXN59_09630	COG3105	Protein conserved in bacteria
FXN59_09635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FXN59_09655	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FXN59_09660	COG3683	transport system, periplasmic component
FXN59_09665	COG0488	(ABC) transporter
FXN59_09675	COG3293	Transposase
FXN59_09680	COG0187	DNA topoisomerase II activity
FXN59_09690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FXN59_09695	COG0625	glutathione transferase activity
FXN59_09700	COG2885	chlorophyll binding
FXN59_09700	COG3047	cAMP biosynthetic process
FXN59_09705	COG0616	signal peptide processing
FXN59_09710	COG3293	Transposase
FXN59_09720	COG1252	NADH dehydrogenase
FXN59_09730	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FXN59_09740	COG0792	nuclease activity
FXN59_09745	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FXN59_09750	COG2823	Periplasmic or secreted lipoprotein
FXN59_09760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN59_09760	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FXN59_09765	COG0785	Cytochrome C biogenesis protein
FXN59_09770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FXN59_09785	COG2801	Transposase and inactivated derivatives
FXN59_09795	COG3069	C4-dicarboxylate transmembrane transporter activity
FXN59_09805	COG3077	Addiction module antitoxin, RelB DinJ family
FXN59_09810	COG3041	Addiction module toxin RelE StbE family
FXN59_09825	COG2351	hydroxyisourate hydrolase activity
FXN59_09830	COG0825	malonyl-CoA metabolic process
FXN59_09845	COG2252	PERMEase
FXN59_09850	COG3152	Membrane
FXN59_09855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FXN59_09860	COG0375	protein maturation
FXN59_09865	COG2814	Major facilitator Superfamily
FXN59_09870	COG0563	adenylate kinase activity
FXN59_09875	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FXN59_09880	COG3025	triphosphatase activity
FXN59_09885	COG1392	Phosphate transport regulator
FXN59_09890	COG0306	phosphate transporter
FXN59_09895	COG4991	sh3 domain protein
FXN59_09905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FXN59_09910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FXN59_09925	COG1620	l-lactate permease
FXN59_09945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FXN59_10000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FXN59_10010	COG1862	Preprotein translocase
FXN59_10015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN59_10020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FXN59_10030	COG1454	alcohol dehydrogenase
FXN59_10030	COG1012	belongs to the aldehyde dehydrogenase family
FXN59_10035	COG1172	Belongs to the binding-protein-dependent transport system permease family
FXN59_10070	COG0720	synthase
FXN59_10075	COG0602	queuosine metabolic process
FXN59_10080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FXN59_10085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FXN59_10095	COG0783	Belongs to the Dps family
FXN59_10100	COG1566	PFAM secretion protein HlyD family protein
FXN59_10105	COG2814	Major facilitator Superfamily
FXN59_10155	COG2927	DNA polymerase III (CHI subunit)
FXN59_10160	COG0114	fumarate hydratase activity
FXN59_10165	COG2268	Band 7 protein
FXN59_10180	COG0778	Nitroreductase
FXN59_10185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FXN59_10195	COG0814	amino acid
FXN59_10215	COG3392	D12 class N6 adenine-specific DNA methyltransferase
FXN59_10270	COG0235	Class ii aldolase
FXN59_10275	COG3623	hexulose-6-phosphate isomerase
FXN59_10300	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FXN59_10335	COG3293	Transposase
FXN59_10350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FXN59_10355	COG3962	Belongs to the TPP enzyme family
FXN59_10365	COG0673	inositol 2-dehydrogenase activity
FXN59_10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FXN59_10375	COG2274	protein secretion by the type I secretion system
FXN59_10380	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FXN59_10385	COG2994	toxin metabolic process
FXN59_10395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FXN59_10415	COG2813	Specifically methylates the guanine in position
FXN59_10420	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FXN59_10425	COG0456	acetyltransferase
FXN59_10430	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FXN59_10450	COG2165	general secretion pathway protein
FXN59_10475	COG3064	Membrane
FXN59_10480	COG0848	biopolymer transport protein
FXN59_10485	COG0811	peptide transport
FXN59_10490	COG0824	Thioesterase
FXN59_10505	COG1294	oxidase, subunit
FXN59_10510	COG1271	oxidase subunit
FXN59_10540	COG0217	transcriptional regulatory protein
FXN59_10545	COG0494	nUDIX hydrolase
FXN59_10560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FXN59_10565	COG3293	Transposase
FXN59_10570	COG1755	Isoprenylcysteine carboxyl methyltransferase
FXN59_10585	COG2271	Major facilitator Superfamily
FXN59_10595	COG0346	lactoylglutathione lyase activity
FXN59_10600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FXN59_10605	COG2056	Na+-H+ antiporter family
FXN59_10630	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FXN59_10635	COG0142	geranyltranstransferase activity
FXN59_10650	COG0697	spore germination
FXN59_10655	COG0697	spore germination
FXN59_10660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FXN59_10670	COG4166	transmembrane transport
FXN59_10675	COG0601	transmembrane transport
FXN59_10680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FXN59_10685	COG0444	Belongs to the ABC transporter superfamily
FXN59_10690	COG4608	Belongs to the ABC transporter superfamily
FXN59_10695	COG0745	RESPONSE REGULATOR receiver
FXN59_10710	COG1611	Belongs to the LOG family
FXN59_10720	COG2259	Doxx family
FXN59_10730	COG1530	ribonuclease E activity
FXN59_10750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FXN59_10755	COG0626	cystathionine gamma-synthase activity
FXN59_10790	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FXN59_10795	COG1959	2 iron, 2 sulfur cluster binding
FXN59_10805	COG0822	iron-sulfur transferase activity
FXN59_10820	COG0443	Heat shock 70 kDa protein
FXN59_10825	COG0633	Ferredoxin
FXN59_10830	COG2975	iron-sulfur cluster assembly
FXN59_10835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN59_10835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FXN59_10840	COG0489	protein tyrosine kinase activity
FXN59_10855	COG2801	Transposase and inactivated derivatives
FXN59_10915	COG3842	ATPase activity
FXN59_10920	COG1176	ABC-type spermidine putrescine transport system, permease component I
FXN59_10925	COG1177	transmembrane transport
FXN59_10930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FXN59_10945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FXN59_10950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FXN59_10965	COG1522	sequence-specific DNA binding
FXN59_10975	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FXN59_10980	COG1178	ABC-type Fe3 transport system permease component
FXN59_10985	COG4143	(ABC) transporter
FXN59_11005	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FXN59_11025	COG2920	part of a sulfur-relay system
FXN59_11035	COG1121	(ABC) transporter
FXN59_11040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_11045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FXN59_11060	COG1803	Methylglyoxal synthase
FXN59_11065	COG3304	Inner membrane component domain
FXN59_11070	COG1289	transmembrane transporter activity
FXN59_11085	COG3958	Transketolase
FXN59_11090	COG3959	Transketolase, thiamine diphosphate binding domain
FXN59_11130	COG4953	penicillin-binding protein 1C
FXN59_11135	COG3293	Transposase
FXN59_11140	COG2855	membrane
FXN59_11155	COG0157	Belongs to the NadC ModD family
FXN59_11160	COG3842	ATPase activity
FXN59_11165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FXN59_11170	COG0725	ABC transporter, periplasmic molybdate-binding protein
FXN59_11180	COG5339	Protein conserved in bacteria
FXN59_11185	COG0443	Heat shock 70 kDa protein
FXN59_11190	COG0484	heat shock protein binding
FXN59_11195	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN59_11210	COG0626	cystathionine gamma-synthase activity
FXN59_11215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FXN59_11245	COG1487	ribonuclease activity
FXN59_11255	COG2337	Toxic component of a toxin-antitoxin (TA) module
FXN59_11280	COG3021	interspecies interaction between organisms
FXN59_11310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FXN59_11335	COG3177	Filamentation induced by cAMP protein fic
FXN59_11395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FXN59_11400	COG2999	glutathione oxidoreductase activity
FXN59_11410	COG1530	ribonuclease E activity
FXN59_11415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FXN59_11440	COG3293	Transposase
FXN59_11450	COG3293	Transposase
FXN59_11475	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_11480	COG1840	ABC-type Fe3 transport system, periplasmic component
FXN59_11500	COG2801	Transposase and inactivated derivatives
FXN59_11505	COG3293	Transposase
FXN59_11515	COG2860	membrane
FXN59_11525	COG3293	Transposase
FXN59_11535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FXN59_11545	COG3293	Transposase
FXN59_11550	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FXN59_11555	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FXN59_11560	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FXN59_11565	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FXN59_11590	COG2850	peptidyl-arginine hydroxylation
FXN59_11605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FXN59_11610	COG1137	ATPase activity
FXN59_11615	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FXN59_11620	COG3117	lipopolysaccharide transmembrane transporter activity
FXN59_11625	COG1127	ABC transporter
FXN59_11630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FXN59_11635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FXN59_11640	COG2854	intermembrane phospholipid transfer
FXN59_11645	COG3113	response to antibiotic
FXN59_11650	COG5007	Belongs to the BolA IbaG family
FXN59_11675	COG3691	Protein conserved in bacteria
FXN59_11685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FXN59_11695	COG0861	Integral membrane protein TerC family
FXN59_11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FXN59_11725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FXN59_11745	COG1125	glycine betaine transport
FXN59_11745	COG0517	IMP dehydrogenase activity
FXN59_11750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FXN59_11760	COG0527	aspartate kinase activity
FXN59_11760	COG0460	homoserine dehydrogenase
FXN59_11775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FXN59_11780	COG2091	lysine biosynthetic process via aminoadipic acid
FXN59_11785	COG0330	HflC and HflK could
FXN59_11790	COG0330	HflC and HflK could
FXN59_11800	COG0544	peptidyl-prolyl cis-trans isomerase activity
FXN59_11805	COG4974	Belongs to the 'phage' integrase family
FXN59_11810	COG2814	Major facilitator Superfamily
FXN59_11815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FXN59_11830	COG3266	domain, Protein
FXN59_11830	COG3061	Opacity-associated protein A
FXN59_11835	COG1509	lysine 2,3-aminomutase activity
FXN59_11845	COG3033	Beta-eliminating lyase
FXN59_11850	COG0814	amino acid
FXN59_11855	COG2964	Protein conserved in bacteria
FXN59_11860	COG5413	integral membrane protein
FXN59_11870	COG0204	Acyl-transferase
FXN59_11880	COG0697	spore germination
FXN59_11885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FXN59_11890	COG1882	Formate acetyltransferase
FXN59_11895	COG2116	formate transmembrane transporter activity
FXN59_11900	COG0537	adenosine 5'-monophosphoramidase activity
FXN59_11935	COG3022	response to hydroperoxide
FXN59_11940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FXN59_11955	COG0681	Belongs to the peptidase S26 family
FXN59_11990	COG0230	Belongs to the bacterial ribosomal protein bL34 family