locus-tag	class	description
BBH51_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBH51_00010	COG0592	DNA-directed DNA polymerase activity
BBH51_00020	COG2226	methyltransferase
BBH51_00030	COG2081	HI0933 family
BBH51_00035	COG4235	cytochrome complex assembly
BBH51_00035	COG3088	subunit of a heme lyase
BBH51_00040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBH51_00045	COG1138	Cytochrome C-type biogenesis protein
BBH51_00050	COG3301	Polysulphide reductase, NrfD
BBH51_00055	COG0437	4 iron, 4 sulfur cluster binding
BBH51_00060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BBH51_00095	COG1138	Cytochrome C-type biogenesis protein
BBH51_00105	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBH51_00110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBH51_00115	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BBH51_00120	COG4133	protoheme IX ABC transporter activity
BBH51_00125	COG2814	Major facilitator Superfamily
BBH51_00180	COG2267	carboxylic ester hydrolase activity
BBH51_00185	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BBH51_00210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BBH51_00215	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BBH51_00220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBH51_00230	COG1652	LysM domain
BBH51_00235	COG2321	neutral zinc metallopeptidase
BBH51_00250	COG0280	phosphate acetyltransferase
BBH51_00250	COG0281	malic enzyme
BBH51_00295	COG3091	SprT-like family
BBH51_00300	COG0814	amino acid
BBH51_00305	COG1760	l-serine dehydratase
BBH51_00310	COG0252	asparaginase activity
BBH51_00320	COG3063	Type IV pilus biogenesis stability protein PilW
BBH51_00325	COG1426	Protein conserved in bacteria
BBH51_00340	COG2976	Protein conserved in bacteria
BBH51_00350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BBH51_00355	COG2233	PERMEase
BBH51_00360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BBH51_00365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBH51_00380	COG0659	secondary active sulfate transmembrane transporter activity
BBH51_00400	COG2186	Transcriptional regulator
BBH51_00415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBH51_00425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBH51_00430	COG1028	Short-chain dehydrogenase reductase Sdr
BBH51_00440	COG0800	Aldolase
BBH51_00450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBH51_00455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BBH51_00460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBH51_00470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BBH51_00475	COG1555	photosystem II stabilization
BBH51_00485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BBH51_00505	COG0196	riboflavin kinase activity
BBH51_00510	COG0728	peptidoglycan biosynthetic process
BBH51_00525	COG0560	Phosphoserine phosphatase
BBH51_00535	COG0193	aminoacyl-tRNA hydrolase activity
BBH51_00540	COG0012	GTP binding
BBH51_00545	COG1573	uracil-dna glycosylase
BBH51_00550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BBH51_00560	COG3115	cell septum assembly
BBH51_00580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BBH51_00585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BBH51_00595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBH51_00605	COG0582	viral genome integration into host DNA
BBH51_00625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BBH51_00630	COG0255	Belongs to the universal ribosomal protein uL29 family
BBH51_00635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BBH51_00640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BBH51_00645	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BBH51_00650	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BBH51_00655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BBH51_00660	COG0089	rRNA binding
BBH51_00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BBH51_00675	COG0051	transcription antitermination factor activity, RNA binding
BBH51_00680	COG0583	DNA-binding transcription factor activity
BBH51_00685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BBH51_00690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BBH51_00695	COG2031	fatty acid transporter
BBH51_00700	COG0183	Belongs to the thiolase family
BBH51_00710	COG1288	antiporter activity
BBH51_00715	COG0549	Belongs to the carbamate kinase family
BBH51_00720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BBH51_00725	COG0038	chloride channel
BBH51_00730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BBH51_00740	COG1522	sequence-specific DNA binding
BBH51_00745	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BBH51_00755	COG1393	Belongs to the ArsC family
BBH51_00765	COG3036	rescue of stalled ribosome
BBH51_00770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BBH51_00775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBH51_00795	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BBH51_00805	COG0569	domain protein
BBH51_00810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BBH51_00810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BBH51_00850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBH51_00870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBH51_00875	COG2990	Protein conserved in bacteria
BBH51_00885	COG0606	chelatase, subunit chli
BBH51_00890	COG2861	carbohydrate metabolic process
BBH51_00895	COG4942	peptidase
BBH51_00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BBH51_00930	COG1253	flavin adenine dinucleotide binding
BBH51_00940	COG0084	hydrolase, TatD family'
BBH51_00945	COG0470	DNA polymerase III
BBH51_00950	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BBH51_00955	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BBH51_00960	COG0347	Belongs to the P(II) protein family
BBH51_00965	COG1349	DNA-binding transcription factor activity
BBH51_00970	COG2084	Dehydrogenase
BBH51_00975	COG3395	kinase activity
BBH51_00980	COG0235	Class ii aldolase
BBH51_00985	COG3622	Belongs to the hyi family
BBH51_00990	COG2610	gluconate transmembrane transporter activity
BBH51_01000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BBH51_01010	COG0561	phosphatase activity
BBH51_01065	COG3085	chromosome segregation
BBH51_01070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBH51_01075	COG3084	Protein conserved in bacteria
BBH51_01080	COG0746	molybdenum cofactor guanylyltransferase activity
BBH51_01090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_01090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_01095	COG1105	Belongs to the carbohydrate kinase PfkB family
BBH51_01100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBH51_01100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BBH51_01100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BBH51_01140	COG2826	transposase and inactivated derivatives, IS30 family
BBH51_01210	COG4964	Belongs to the GSP D family
BBH51_01235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BBH51_01245	COG1444	tRNA N-acetyltransferase activity
BBH51_01250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BBH51_01260	COG1126	abc transporter atp-binding protein
BBH51_01265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBH51_01270	COG4215	(ABC) transporter
BBH51_01275	COG4160	amino acid transport
BBH51_01280	COG1966	Carbon starvation protein
BBH51_01295	COG3116	cell division
BBH51_01300	COG0768	penicillin binding
BBH51_01310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBH51_01330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BBH51_01345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BBH51_01350	COG0849	cell division
BBH51_01355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBH51_01365	COG1605	Chorismate mutase
BBH51_01365	COG0077	Prephenate dehydratase
BBH51_01370	COG0326	Molecular chaperone. Has ATPase activity
BBH51_01375	COG1393	Belongs to the ArsC family
BBH51_01385	COG1876	peptidase activity
BBH51_01390	COG0494	nUDIX hydrolase
BBH51_01395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BBH51_01435	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BBH51_01440	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
BBH51_01445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBH51_01450	COG1053	succinate dehydrogenase
BBH51_01460	COG1120	ATPase activity
BBH51_01465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBH51_01470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBH51_01475	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BBH51_01480	COG1408	metallophosphoesterase
BBH51_01490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BBH51_01495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBH51_01500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBH51_01515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBH51_01525	COG0741	lytic transglycosylase activity
BBH51_01530	COG2350	Protein conserved in bacteria
BBH51_01535	COG1607	acyl-coa hydrolase
BBH51_01540	COG2917	probably involved in intracellular septation
BBH51_01550	COG3047	cAMP biosynthetic process
BBH51_01555	COG0497	DNA recombination
BBH51_01565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BBH51_01575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBH51_01575	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BBH51_01580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBH51_01585	COG5002	protein histidine kinase activity
BBH51_01585	COG2198	Histidine kinase
BBH51_01585	COG0784	Response regulator, receiver
BBH51_01590	COG4211	Belongs to the binding-protein-dependent transport system permease family
BBH51_01600	COG1879	ABC-type sugar transport system periplasmic component
BBH51_01605	COG1609	Transcriptional regulator
BBH51_01610	COG1085	galactose-1-phosphate uridylyltransferase
BBH51_01620	COG2017	converts alpha-aldose to the beta-anomer
BBH51_01635	COG0471	metal ion transport
BBH51_01640	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
BBH51_01640	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BBH51_01645	COG3051	citrate lyase alpha subunit
BBH51_01650	COG2301	Belongs to the HpcH HpaI aldolase family
BBH51_01660	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BBH51_01665	COG4535	Mg2 and Co2 transporter CorC
BBH51_01685	COG0105	UTP biosynthetic process
BBH51_01705	COG4942	peptidase
BBH51_01705	COG1388	LysM domain
BBH51_01715	COG1238	metal cluster binding
BBH51_01745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBH51_01760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBH51_01775	COG1285	pathogenesis
BBH51_01785	COG2826	transposase and inactivated derivatives, IS30 family
BBH51_01810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBH51_01820	COG0251	oxidation-reduction process
BBH51_01825	COG2137	regulation of response to DNA damage stimulus
BBH51_01830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BBH51_01840	COG2095	MarC family integral membrane protein
BBH51_01915	COG1238	metal cluster binding
BBH51_01920	COG0110	maltose O-acetyltransferase activity
BBH51_01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBH51_01950	COG0210	DNA helicase
BBH51_01955	COG5645	(Lipo)protein
BBH51_01965	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBH51_01965	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BBH51_01975	COG0243	molybdopterin cofactor binding
BBH51_01980	COG0437	4 iron, 4 sulfur cluster binding
BBH51_01985	COG3302	dmso reductase anchor subunit
BBH51_01990	COG3381	protein complex oligomerization
BBH51_02005	COG4545	Glutaredoxin-related protein
BBH51_02015	COG4804	nuclease activity
BBH51_02035	COG1114	Component of the transport system for branched-chain amino acids
BBH51_02050	COG1040	competence protein
BBH51_02055	COG0561	phosphatase activity
BBH51_02060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBH51_02065	COG1596	polysaccharide export
BBH51_02065	COG1555	photosystem II stabilization
BBH51_02085	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BBH51_02090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBH51_02100	COG1011	Hydrolase
BBH51_02125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BBH51_02180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBH51_02190	COG1028	Short-chain dehydrogenase reductase Sdr
BBH51_02195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BBH51_02270	COG0459	protein refolding
BBH51_02275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BBH51_02285	COG1027	Aspartate ammonia-lyase
BBH51_02290	COG0859	PFAM glycosyl transferase family 9
BBH51_02295	COG3716	PTS system mannose fructose sorbose family IID component
BBH51_02300	COG3715	PTS system
BBH51_02305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_02305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBH51_02315	COG2207	Transcriptional regulator
BBH51_02315	COG1609	Transcriptional regulator
BBH51_02320	COG1757	Na H antiporter
BBH51_02325	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBH51_02340	COG1129	ABC transporter
BBH51_02345	COG4213	ABC transporter substrate-binding protein
BBH51_02350	COG2115	Belongs to the xylose isomerase family
BBH51_02365	COG3070	regulator of competence-specific genes
BBH51_02370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBH51_02380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBH51_02385	COG3850	Histidine kinase
BBH51_02390	COG3062	negative regulation of establishment of protein localization
BBH51_02395	COG0243	molybdopterin cofactor binding
BBH51_02400	COG0437	4 iron, 4 sulfur cluster binding
BBH51_02405	COG0348	domain, Protein
BBH51_02410	COG3043	anaerobic respiration
BBH51_02415	COG3005	denitrification pathway
BBH51_02420	COG0754	glutathionylspermidine amidase activity
BBH51_02425	COG0859	PFAM glycosyl transferase family 9
BBH51_02435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBH51_02445	COG0737	Belongs to the 5'-nucleotidase family
BBH51_02470	COG3501	Rhs element vgr protein
BBH51_02500	COG1349	DNA-binding transcription factor activity
BBH51_02510	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BBH51_02520	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BBH51_02525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBH51_02540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BBH51_02550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BBH51_02570	COG3312	ion transport
BBH51_02580	COG1733	regulation of RNA biosynthetic process
BBH51_02585	COG0702	epimerase
BBH51_02595	COG0716	FMN binding
BBH51_02605	COG1494	fructose-1,6-bisphosphatase
BBH51_02615	COG1045	serine acetyltransferase
BBH51_02625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BBH51_02630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BBH51_02635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBH51_02640	COG4988	ABC transporter
BBH51_02645	COG1132	(ABC) transporter
BBH51_02650	COG1309	transcriptional regulator
BBH51_02655	COG0583	DNA-binding transcription factor activity
BBH51_02660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBH51_02660	COG0678	peroxiredoxin activity
BBH51_02670	COG0545	Peptidyl-prolyl cis-trans isomerase
BBH51_02675	COG2964	Protein conserved in bacteria
BBH51_02680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BBH51_02690	COG2168	tRNA wobble position uridine thiolation
BBH51_02695	COG1126	abc transporter atp-binding protein
BBH51_02700	COG0765	amino acid transport
BBH51_02705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBH51_02710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BBH51_02740	COG1686	Belongs to the peptidase S11 family
BBH51_02745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBH51_02745	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBH51_02750	COG0772	Belongs to the SEDS family
BBH51_02755	COG0768	penicillin binding
BBH51_02765	COG0799	negative regulation of ribosome biogenesis
BBH51_02770	COG0513	Belongs to the DEAD box helicase family
BBH51_02775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BBH51_02780	COG2814	Major facilitator Superfamily
BBH51_02790	COG1028	Short-chain dehydrogenase reductase Sdr
BBH51_02795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BBH51_02805	COG0416	fatty acid biosynthetic process
BBH51_02810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BBH51_02815	COG1399	metal-binding, possibly nucleic acid-binding protein
BBH51_02825	COG0500	methyltransferase
BBH51_02830	COG2830	Protein of unknown function (DUF452)
BBH51_02840	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BBH51_02845	COG0688	phosphatidylethanolamine metabolic process
BBH51_02850	COG0545	Peptidyl-prolyl cis-trans isomerase
BBH51_02865	COG2966	Psort location CytoplasmicMembrane, score
BBH51_02870	COG3610	response to peptide
BBH51_02875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BBH51_02905	COG3501	Rhs element vgr protein
BBH51_02910	COG1609	Transcriptional regulator
BBH51_02915	COG2949	membrane
BBH51_02920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BBH51_02940	COG0583	DNA-binding transcription factor activity
BBH51_02950	COG0009	L-threonylcarbamoyladenylate synthase
BBH51_02955	COG1605	Chorismate mutase
BBH51_02955	COG0287	Prephenate dehydrogenase
BBH51_02960	COG0616	signal peptide processing
BBH51_02965	COG0778	Nitroreductase
BBH51_02970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBH51_02975	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBH51_02980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BBH51_02990	COG2909	trisaccharide binding
BBH51_02995	COG0058	SHG alpha-glucan phosphorylase activity
BBH51_03000	COG1640	4-alpha-glucanotransferase
BBH51_03005	COG1286	toxin biosynthetic process
BBH51_03010	COG3092	negative regulation of chromosome organization
BBH51_03015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBH51_03020	COG0280	phosphate acetyltransferase
BBH51_03020	COG0857	belongs to the CobB CobQ family
BBH51_03030	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BBH51_03035	COG0617	tRNA 3'-terminal CCA addition
BBH51_03040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BBH51_03045	COG2333	competence protein COMEC
BBH51_03045	COG0658	competence protein
BBH51_03050	COG1132	(ABC) transporter
BBH51_03055	COG1663	tetraacyldisaccharide 4'-kinase activity
BBH51_03060	COG2835	tetraacyldisaccharide 4'-kinase activity
BBH51_03070	COG0322	excinuclease ABC activity
BBH51_03080	COG0395	ABC-type sugar transport system, permease component
BBH51_03085	COG1175	transmembrane transport
BBH51_03100	COG3177	Filamentation induced by cAMP protein fic
BBH51_03110	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BBH51_03115	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBH51_03125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BBH51_03140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BBH51_03155	COG0195	Participates in both transcription termination and antitermination
BBH51_03220	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BBH51_03225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBH51_03240	COG2960	long-chain fatty acid transporting porin activity
BBH51_03245	COG3172	ATPase kinase involved in NAD metabolism
BBH51_03250	COG2129	metallophosphoesterase
BBH51_03255	COG0814	amino acid
BBH51_03270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BBH51_03285	COG0201	protein transport
BBH51_03295	COG1841	ribosomal large subunit assembly
BBH51_03305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BBH51_03315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BBH51_03325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BBH51_03335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BBH51_03350	COG0805	protein transport
BBH51_03355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBH51_03360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BBH51_03390	COG1459	type II secretion system
BBH51_03395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BBH51_03400	COG4969	Belongs to the N-Me-Phe pilin family
BBH51_03405	COG3023	N-Acetylmuramoyl-L-alanine amidase
BBH51_03410	COG2731	YhcH YjgK YiaL family protein
BBH51_03420	COG4785	May be involved in cell division
BBH51_03425	COG0513	Belongs to the DEAD box helicase family
BBH51_03435	COG3835	regulator
BBH51_03440	COG2610	gluconate transmembrane transporter activity
BBH51_03445	COG1929	Belongs to the glycerate kinase type-1 family
BBH51_03450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBH51_03455	COG0312	modulator of DNA gyrase
BBH51_03460	COG3028	Belongs to the UPF0307 family
BBH51_03465	COG0471	metal ion transport
BBH51_03475	COG1575	Belongs to the MenA family. Type 1 subfamily
BBH51_03480	COG1720	tRNA m6t6A37 methyltransferase activity
BBH51_03510	COG2177	Part of the ABC transporter FtsEX involved in
BBH51_03515	COG2884	Cell division ATP-binding protein ftsE
BBH51_03520	COG0552	protein localization to endoplasmic reticulum
BBH51_03525	COG0742	ribosomal rna small subunit methyltransferase
BBH51_03530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBH51_03530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_03535	COG3715	PTS system
BBH51_03540	COG3716	PTS system mannose fructose sorbose family IID component
BBH51_03545	COG0561	phosphatase activity
BBH51_03550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BBH51_03565	COG1649	PFAM Uncharacterised BCR, COG1649
BBH51_03565	COG0726	polysaccharide deacetylase
BBH51_03570	COG1215	transferase activity, transferring glycosyl groups
BBH51_03580	COG2271	Major facilitator Superfamily
BBH51_03595	COG3293	Transposase
BBH51_03605	COG2801	Transposase and inactivated derivatives
BBH51_03625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BBH51_03635	COG1758	RNA polymerase activity
BBH51_03640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBH51_03650	COG3161	chorismate lyase activity
BBH51_03695	COG2801	Transposase and inactivated derivatives
BBH51_03700	COG0237	dephospho-CoA kinase activity
BBH51_03700	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BBH51_03705	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BBH51_03715	COG1115	amino acid carrier protein
BBH51_03720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBH51_03745	COG2184	nucleotidyltransferase activity
BBH51_03750	COG4145	pantothenate transmembrane transporter activity
BBH51_03755	COG3924	membrane
BBH51_03770	COG0439	Biotin carboxylase
BBH51_03775	COG0511	ligase activity, forming carbon-carbon bonds
BBH51_03800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BBH51_03810	COG0456	acetyltransferase
BBH51_03815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BBH51_03825	COG3078	GTPase activator activity
BBH51_03840	COG3201	nicotinamide mononucleotide transporter
BBH51_03850	COG0513	Belongs to the DEAD box helicase family
BBH51_03895	COG1181	Belongs to the D-alanine--D-alanine ligase family
BBH51_03895	COG2918	glutathione biosynthetic process
BBH51_03900	COG2194	sulfuric ester hydrolase activity
BBH51_03905	COG0740	serine-type endopeptidase activity
BBH51_03925	COG3739	integral membrane protein
BBH51_03930	COG2217	Heavy metal translocating P-type atpase
BBH51_03935	COG2608	mercury ion transmembrane transporter activity
BBH51_03955	COG2932	Transcriptional regulator
BBH51_03975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BBH51_03995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBH51_04040	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BBH51_04045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BBH51_04050	COG1011	Hydrolase
BBH51_04055	COG0494	nUDIX hydrolase
BBH51_04060	COG1917	Cupin 2, conserved barrel domain protein
BBH51_04060	COG4977	sequence-specific DNA binding
BBH51_04065	COG3059	membrane
BBH51_04070	COG1297	OPT oligopeptide transporter protein
BBH51_04080	COG1218	3'(2'),5'-bisphosphate nucleotidase
BBH51_04085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BBH51_04090	COG0363	glucosamine-6-phosphate deaminase activity
BBH51_04110	COG0762	integral membrane protein
BBH51_04120	COG0778	Nitroreductase
BBH51_04160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBH51_04180	COG0006	proline dipeptidase activity
BBH51_04205	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BBH51_04210	COG1792	Involved in formation and maintenance of cell shape
BBH51_04215	COG1077	Cell shape determining protein MreB Mrl
BBH51_04220	COG0557	exoribonuclease II activity
BBH51_04230	COG2271	Major facilitator Superfamily
BBH51_04235	COG0584	glycerophosphoryl diester phosphodiesterase
BBH51_04240	COG0758	DNA mediated transformation
BBH51_04275	COG1132	(ABC) transporter
BBH51_04280	COG4977	sequence-specific DNA binding
BBH51_04280	COG1917	Cupin 2, conserved barrel domain protein
BBH51_04285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BBH51_04290	COG0859	PFAM glycosyl transferase family 9
BBH51_04305	COG1519	Transferase
BBH51_04310	COG0463	Glycosyl transferase, family 2
BBH51_04325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBH51_04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBH51_04335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BBH51_04340	COG3719	Belongs to the RNase T2 family
BBH51_04350	COG0191	fructose-bisphosphate aldolase activity
BBH51_04355	COG3307	-O-antigen
BBH51_04360	COG2267	carboxylic ester hydrolase activity
BBH51_04365	COG0561	phosphatase activity
BBH51_04370	COG0028	Belongs to the TPP enzyme family
BBH51_04375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBH51_04400	COG1072	(Pantothenic acid kinase))
BBH51_04405	COG0187	DNA topoisomerase II activity
BBH51_04410	COG0514	ATP-dependent DNA helicase (RecQ)
BBH51_04420	COG0019	diaminopimelate decarboxylase activity
BBH51_04425	COG3477	response to acidic pH
BBH51_04430	COG2818	Glycosylase
BBH51_04435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BBH51_04445	COG2195	Cleaves the N-terminal amino acid of tripeptides
BBH51_04450	COG0300	oxidoreductase activity
BBH51_04455	COG1763	Mo-molybdopterin cofactor biosynthetic process
BBH51_04460	COG3086	response to oxidative stress
BBH51_04465	COG3026	antisigma factor binding
BBH51_04470	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BBH51_04475	COG1595	DNA-templated transcription, initiation
BBH51_04490	COG0442	prolyl-tRNA aminoacylation
BBH51_04495	COG1921	L-seryl-tRNASec selenium transferase activity
BBH51_04500	COG3276	selenocysteine insertion sequence binding
BBH51_04560	COG0521	Mo-molybdopterin cofactor biosynthetic process
BBH51_04565	COG4589	Belongs to the CDS family
BBH51_04575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBH51_04580	COG0471	metal ion transport
BBH51_04580	COG0490	domain, Protein
BBH51_04600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBH51_04610	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BBH51_04625	COG0575	Belongs to the CDS family
BBH51_04640	COG0233	cytoplasmic translational termination
BBH51_04655	COG4178	(ABC) transporter
BBH51_04665	COG1349	DNA-binding transcription factor activity
BBH51_04670	COG0705	Rhomboid family
BBH51_04695	COG0551	DNA topoisomerase type I activity
BBH51_04710	COG2962	Rard protein
BBH51_04715	COG0583	DNA-binding transcription factor activity
BBH51_04725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BBH51_04740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BBH51_04745	COG1879	ABC-type sugar transport system periplasmic component
BBH51_04750	COG1129	ABC transporter
BBH51_04755	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBH51_04765	COG2183	response to ionizing radiation
BBH51_04780	COG0583	DNA-binding transcription factor activity
BBH51_04785	COG0471	metal ion transport
BBH51_04795	COG2183	response to ionizing radiation
BBH51_04800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBH51_04810	COG1595	DNA-templated transcription, initiation
BBH51_04820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BBH51_04825	COG3071	HemY protein
BBH51_04830	COG2959	enzyme of heme biosynthesis
BBH51_04840	COG0181	hydroxymethylbilane synthase activity
BBH51_04850	COG2197	response regulator
BBH51_04855	COG0729	surface antigen
BBH51_04860	COG2911	Protein conserved in bacteria
BBH51_04865	COG0248	Ppx GppA phosphatase
BBH51_04885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BBH51_04890	COG3068	Protein conserved in bacteria
BBH51_04900	COG1349	DNA-binding transcription factor activity
BBH51_04905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBH51_04925	COG2272	Belongs to the type-B carboxylesterase lipase family
BBH51_04930	COG0667	Aldo Keto reductase
BBH51_04935	COG0656	L-ascorbic acid biosynthetic process
BBH51_04950	COG0433	COG0433 Predicted ATPase
BBH51_04955	COG2258	MOSC domain
BBH51_04960	COG3012	SEC-C Motif Domain Protein
BBH51_04970	COG1490	D-aminoacyl-tRNA deacylase activity
BBH51_04975	COG0786	glutamate:sodium symporter activity
BBH51_04980	COG2205	protein histidine kinase activity
BBH51_04985	COG0745	RESPONSE REGULATOR receiver
BBH51_04990	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BBH51_05000	COG3082	Protein of unknown function (DUF1414)
BBH51_05005	COG3083	sulfuric ester hydrolase activity
BBH51_05010	COG0402	S-adenosylhomocysteine deaminase activity
BBH51_05015	COG3956	TIGRFAM MazG family protein
BBH51_05030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BBH51_05040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BBH51_05045	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
BBH51_05050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BBH51_05065	COG0148	phosphopyruvate hydratase activity
BBH51_05075	COG2991	Protein conserved in bacteria
BBH51_05080	COG1477	protein flavinylation
BBH51_05085	COG2871	sodium ion transport
BBH51_05090	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBH51_05095	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBH51_05100	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BBH51_05115	COG0271	Belongs to the BolA IbaG family
BBH51_05120	COG3056	Lipoprotein
BBH51_05140	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BBH51_05145	COG1194	a g-specific adenine glycosylase
BBH51_05155	COG3171	Protein conserved in bacteria
BBH51_05160	COG1840	ABC-type Fe3 transport system, periplasmic component
BBH51_05165	COG1178	ABC-type Fe3 transport system permease component
BBH51_05170	COG3842	ATPase activity
BBH51_05185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBH51_05195	COG1561	YicC-like family, N-terminal region
BBH51_05200	COG0354	folic acid binding
BBH51_05215	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BBH51_05220	COG1381	Involved in DNA repair and RecF pathway recombination
BBH51_05225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BBH51_05230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBH51_05235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BBH51_05245	COG0500	methyltransferase
BBH51_05250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BBH51_05255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBH51_05260	COG1309	transcriptional regulator
BBH51_05265	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BBH51_05270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBH51_05285	COG3306	glycosyltransferase involved in LPS biosynthesis
BBH51_05295	COG3306	glycosyltransferase involved in LPS biosynthesis
BBH51_05315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBH51_05330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBH51_05340	COG1309	transcriptional regulator
BBH51_05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBH51_05360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BBH51_05365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BBH51_05370	COG4972	Pilus assembly protein
BBH51_05390	COG4796	Type ii and iii secretion system protein
BBH51_05405	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BBH51_05435	COG0653	protein targeting
BBH51_05450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BBH51_05465	COG0789	Transcriptional regulator
BBH51_05470	COG4701	Protein of unknown function (DUF721)
BBH51_05485	COG0494	nUDIX hydrolase
BBH51_05490	COG1466	dna polymerase III delta subunit
BBH51_05495	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
BBH51_05510	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BBH51_05515	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
BBH51_05520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BBH51_05525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BBH51_05530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BBH51_05550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBH51_05555	COG4221	oxidoreductase activity
BBH51_05560	COG0789	Transcriptional regulator
BBH51_05565	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BBH51_05570	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBH51_05575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BBH51_05580	COG4137	Cytochrome C assembly protein
BBH51_05585	COG4536	flavin adenine dinucleotide binding
BBH51_05590	COG0811	peptide transport
BBH51_05595	COG0848	biopolymer transport protein
BBH51_05605	COG4783	chaperone-mediated protein folding
BBH51_05615	COG0814	amino acid
BBH51_05640	COG0747	negative chemotaxis
BBH51_05645	COG2853	Lipoprotein
BBH51_05655	COG3501	Rhs element vgr protein
BBH51_05675	COG3718	enzyme involved in inositol metabolism
BBH51_05685	COG2271	Major facilitator Superfamily
BBH51_05705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBH51_05715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBH51_05720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BBH51_05725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BBH51_05730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBH51_05735	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
BBH51_05740	COG0310	cobalt ion transport
BBH51_05745	COG0310	cobalt ion transport
BBH51_05750	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BBH51_05755	COG1122	ATPase activity
BBH51_05760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BBH51_05765	COG0409	Hydrogenase expression formation protein
BBH51_05770	COG0309	Hydrogenase expression formation protein (HypE)
BBH51_05800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BBH51_05805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBH51_05810	COG0795	lipopolysaccharide-transporting ATPase activity
BBH51_05815	COG0795	lipopolysaccharide-transporting ATPase activity
BBH51_05825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BBH51_05830	COG4149	molybdate abc transporter
BBH51_05835	COG0725	ABC transporter, periplasmic molybdate-binding protein
BBH51_05840	COG2005	Transcriptional regulator
BBH51_05845	COG0471	metal ion transport
BBH51_05855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBH51_05860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBH51_05860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BBH51_05865	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBH51_05875	COG0583	DNA-binding transcription factor activity
BBH51_05880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBH51_05890	COG0039	L-malate dehydrogenase activity
BBH51_05895	COG1438	arginine binding
BBH51_05900	COG1090	epimerase
BBH51_05905	COG4657	Part of a membrane complex involved in electron transport
BBH51_05935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BBH51_05940	COG0733	neurotransmitter:sodium symporter activity
BBH51_05945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBH51_05960	COG4604	ABC transporter, ATP-binding protein
BBH51_05965	COG4605	iron ion homeostasis
BBH51_05970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BBH51_05975	COG4607	ABC-type enterochelin transport system periplasmic component
BBH51_05980	COG0737	Belongs to the 5'-nucleotidase family
BBH51_05995	COG0745	RESPONSE REGULATOR receiver
BBH51_06000	COG0745	RESPONSE REGULATOR receiver
BBH51_06010	COG0405	Gamma-glutamyltransferase
BBH51_06025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BBH51_06030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BBH51_06035	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
BBH51_06080	COG1518	maintenance of DNA repeat elements
BBH51_06085	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BBH51_06095	COG0583	DNA-binding transcription factor activity
BBH51_06100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BBH51_06105	COG1687	branched-chain amino acid
BBH51_06110	COG0612	Peptidase, M16
BBH51_06115	COG4771	TonB-dependent receptor
BBH51_06120	COG2990	Protein conserved in bacteria
BBH51_06130	COG0539	negative regulation of cytoplasmic translation
BBH51_06135	COG0776	regulation of translation
BBH51_06140	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BBH51_06145	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BBH51_06155	COG0023	Translation Initiation Factor
BBH51_06160	COG3094	Invasion gene expression up-regulator, SirB
BBH51_06165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBH51_06170	COG0735	belongs to the Fur family
BBH51_06175	COG0716	FMN binding
BBH51_06180	COG0596	Alpha beta hydrolase
BBH51_06185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BBH51_06190	COG0318	PFAM AMP-dependent synthetase and ligase
BBH51_06195	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BBH51_06195	COG3264	Mechanosensitive ion channel
BBH51_06200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BBH51_06205	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BBH51_06210	COG0730	response to heat
BBH51_06215	COG1560	Kdo2-lipid A biosynthetic process
BBH51_06225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBH51_06230	COG3021	interspecies interaction between organisms
BBH51_06235	COG0463	Glycosyl transferase, family 2
BBH51_06250	COG0251	oxidation-reduction process
BBH51_06260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BBH51_06265	COG1757	Na H antiporter
BBH51_06270	COG2916	Histone family protein nucleoid-structuring protein H-NS
BBH51_06275	COG0788	formyltetrahydrofolate deformylase activity
BBH51_06285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBH51_06290	COG3101	peptidyl-lysine hydroxylation
BBH51_06295	COG3842	ATPase activity
BBH51_06300	COG1178	ABC-type Fe3 transport system permease component
BBH51_06305	COG3842	ATPase activity
BBH51_06315	COG1840	ABC-type Fe3 transport system, periplasmic component
BBH51_06320	COG2801	Transposase and inactivated derivatives
BBH51_06350	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
BBH51_06355	COG3098	single-species biofilm formation
BBH51_06370	COG1278	Cold shock
BBH51_06380	COG1067	ATP-dependent peptidase activity
BBH51_06385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BBH51_06395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BBH51_06400	COG1074	ATP-dependent DNA helicase activity
BBH51_06405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBH51_06425	COG0101	tRNA pseudouridine synthase activity
BBH51_06440	COG0471	metal ion transport
BBH51_06445	COG2315	Protein conserved in bacteria
BBH51_06450	COG0243	molybdopterin cofactor binding
BBH51_06455	COG3005	denitrification pathway
BBH51_06485	COG2826	transposase and inactivated derivatives, IS30 family
BBH51_06510	COG1346	cytolysis
BBH51_06525	COG3657	addiction module killer protein
BBH51_06565	COG1523	belongs to the glycosyl hydrolase 13 family
BBH51_06580	COG0058	SHG alpha-glucan phosphorylase activity
BBH51_06585	COG0586	Pfam SNARE associated Golgi protein
BBH51_06590	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BBH51_06600	COG1686	Belongs to the peptidase S11 family
BBH51_06605	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
BBH51_06610	COG0204	Acyl-transferase
BBH51_06610	COG0318	PFAM AMP-dependent synthetase and ligase
BBH51_06615	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BBH51_06620	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BBH51_06625	COG0697	spore germination
BBH51_06630	COG2925	Exonuclease
BBH51_06635	COG1528	Iron-storage protein
BBH51_06640	COG1528	Iron-storage protein
BBH51_06645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BBH51_06650	COG0589	response to stress
BBH51_06655	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
BBH51_06665	COG0613	PHP domain protein
BBH51_06670	COG0167	dihydroorotate dehydrogenase activity
BBH51_06675	COG0308	aminopeptidase N
BBH51_06680	COG1448	Aminotransferase
BBH51_06690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBH51_06695	COG1129	ABC transporter
BBH51_06695	COG0842	Transport permease protein
BBH51_06700	COG0842	Transport permease protein
BBH51_06715	COG0791	NLP P60 protein
BBH51_06730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BBH51_06745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BBH51_06745	COG0517	IMP dehydrogenase activity
BBH51_06750	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BBH51_06755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BBH51_06760	COG0512	Glutamine amidotransferase of anthranilate synthase
BBH51_06765	COG1942	4-Oxalocrotonate Tautomerase
BBH51_06770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBH51_06780	COG3093	addiction module antidote protein HigA
BBH51_06785	COG0135	phosphoribosylanthranilate isomerase activity
BBH51_06785	COG0134	indole-3-glycerol-phosphate synthase activity
BBH51_06795	COG0298	carbon dioxide binding
BBH51_06805	COG3630	sodium ion export across plasma membrane
BBH51_06820	COG4771	TonB-dependent receptor
BBH51_06820	COG1629	transport
BBH51_06825	COG1629	transport
BBH51_06825	COG4771	TonB-dependent receptor
BBH51_06835	COG4221	oxidoreductase activity
BBH51_06840	COG0133	tryptophan synthase activity
BBH51_06850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBH51_06860	COG0469	pyruvate kinase activity
BBH51_06895	COG2390	Transcriptional regulator
BBH51_06900	COG1070	Carbohydrate kinase
BBH51_06905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BBH51_06910	COG1940	carbohydrate kinase activity
BBH51_06920	COG2969	positive regulation of protein catabolic process
BBH51_06930	COG0314	molybdopterin synthase activity
BBH51_06935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BBH51_06945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BBH51_06955	COG3293	Transposase
BBH51_06975	COG1120	ATPase activity
BBH51_06985	COG3585	molybdate ion transport
BBH51_07000	COG1120	ATPase activity
BBH51_07020	COG4774	siderophore transport
BBH51_07035	COG1525	nuclease
BBH51_07040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBH51_07045	COG2166	iron-sulfur cluster assembly
BBH51_07050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BBH51_07050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BBH51_07055	COG1560	Kdo2-lipid A biosynthetic process
BBH51_07060	COG3381	protein complex oligomerization
BBH51_07065	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBH51_07075	COG0330	HflC and HflK could
BBH51_07100	COG1858	cytochrome C peroxidase
BBH51_07110	COG0318	PFAM AMP-dependent synthetase and ligase
BBH51_07115	COG0318	PFAM AMP-dependent synthetase and ligase
BBH51_07120	COG3065	identical protein binding
BBH51_07125	COG1214	PFAM Peptidase M22, glycoprotease
BBH51_07130	COG1199	ATP-dependent helicase activity
BBH51_07135	COG0676	glucose-6-phosphate 1-epimerase activity
BBH51_07145	COG4580	involved in the transport of maltose and maltodextrins
BBH51_07150	COG3842	ATPase activity
BBH51_07155	COG2182	Extracellular solute-binding protein
BBH51_07165	COG3833	ABC-type maltose transport systems, permease component
BBH51_07170	COG0366	Alpha amylase catalytic
BBH51_07175	COG3842	ATPase activity
BBH51_07185	COG1840	ABC-type Fe3 transport system, periplasmic component
BBH51_07195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBH51_07210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BBH51_07220	COG0633	Ferredoxin
BBH51_07230	COG1280	lysine exporter protein (LysE YggA)
BBH51_07235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BBH51_07240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BBH51_07250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BBH51_07260	COG0166	Belongs to the GPI family
BBH51_07270	COG0305	Participates in initiation and elongation during chromosome replication
BBH51_07275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBH51_07280	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBH51_07290	COG4591	ABC-type transport system involved in lipoprotein release permease component
BBH51_07325	COG2983	Belongs to the UPF0260 family
BBH51_07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBH51_07350	COG0577	efflux transmembrane transporter activity
BBH51_07350	COG1136	(ABC) transporter
BBH51_07355	COG1538	Outer membrane efflux protein
BBH51_07365	COG2824	Alkylphosphonate utilization operon protein PhnA
BBH51_07375	COG0564	pseudouridine synthase activity
BBH51_07380	COG2431	L-lysine efflux transmembrane transporter activity
BBH51_07385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BBH51_07390	COG0406	alpha-ribazole phosphatase activity
BBH51_07395	COG0285	dihydrofolate synthase activity
BBH51_07410	COG0142	geranyltranstransferase activity
BBH51_07420	COG1349	DNA-binding transcription factor activity
BBH51_07425	COG1063	alcohol dehydrogenase
BBH51_07430	COG3775	system Galactitol-specific IIC component
BBH51_07435	COG3684	Belongs to the aldolase LacD family
BBH51_07445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BBH51_07455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBH51_07490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBH51_07495	COG0512	Glutamine amidotransferase of anthranilate synthase
BBH51_07505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBH51_07530	COG2832	Protein of unknown function (DUF454)
BBH51_07535	COG0339	signal peptide processing
BBH51_07540	COG2190	(PTS) system
BBH51_07545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBH51_07550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_07625	COG3021	interspecies interaction between organisms
BBH51_07645	COG2337	Toxic component of a toxin-antitoxin (TA) module
BBH51_07680	COG2194	sulfuric ester hydrolase activity
BBH51_07690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BBH51_07705	COG0802	atpase or kinase
BBH51_07710	COG1388	LysM domain
BBH51_07710	COG0860	N-Acetylmuramoyl-L-alanine amidase
BBH51_07725	COG1923	regulation of RNA biosynthetic process
BBH51_07730	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BBH51_07740	COG3106	COG3106 Predicted ATPase
BBH51_07745	COG4166	transmembrane transport
BBH51_07750	COG4168	peptide transport system, permease
BBH51_07755	COG4171	peptide transport system, permease
BBH51_07760	COG4172	Belongs to the ABC transporter superfamily
BBH51_07765	COG4172	Belongs to the ABC transporter superfamily
BBH51_07810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBH51_07815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BBH51_07825	COG0024	Methionine aminopeptidase
BBH51_07830	COG0316	Belongs to the HesB IscA family
BBH51_07840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBH51_07845	COG0672	)-iron permease
BBH51_07860	COG0577	efflux transmembrane transporter activity
BBH51_07860	COG1136	(ABC) transporter
BBH51_07870	COG1136	(ABC) transporter
BBH51_07870	COG0577	efflux transmembrane transporter activity
BBH51_07875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBH51_07885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBH51_07895	COG1643	Atp-dependent helicase
BBH51_07900	COG2363	Small membrane protein
BBH51_07935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BBH51_07940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BBH51_07945	COG0363	glucosamine-6-phosphate deaminase activity
BBH51_07950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBH51_07955	COG1737	Transcriptional regulator
BBH51_07965	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BBH51_07970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BBH51_07975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BBH51_07975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BBH51_07980	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BBH51_07985	COG2190	(PTS) system
BBH51_07985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BBH51_07985	COG1263	PTS System
BBH51_07995	COG3501	Rhs element vgr protein
BBH51_08015	COG3179	chitinase
BBH51_08080	COG1846	Transcriptional regulator
BBH51_08080	COG1940	carbohydrate kinase activity
BBH51_08090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBH51_08095	COG2226	methyltransferase
BBH51_08105	COG3422	double-strand break repair
BBH51_08115	COG1944	ATP diphosphatase activity
BBH51_08120	COG3105	Protein conserved in bacteria
BBH51_08125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BBH51_08145	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BBH51_08150	COG3683	transport system, periplasmic component
BBH51_08155	COG0488	(ABC) transporter
BBH51_08165	COG0187	DNA topoisomerase II activity
BBH51_08170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBH51_08175	COG0625	glutathione transferase activity
BBH51_08180	COG3047	cAMP biosynthetic process
BBH51_08180	COG2885	chlorophyll binding
BBH51_08185	COG0616	signal peptide processing
BBH51_08195	COG1252	NADH dehydrogenase
BBH51_08205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BBH51_08215	COG0792	nuclease activity
BBH51_08220	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BBH51_08225	COG2823	Periplasmic or secreted lipoprotein
BBH51_08230	COG0288	reversible hydration of carbon dioxide
BBH51_08235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBH51_08235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BBH51_08240	COG0785	Cytochrome C biogenesis protein
BBH51_08245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBH51_08260	COG2801	Transposase and inactivated derivatives
BBH51_08270	COG3069	C4-dicarboxylate transmembrane transporter activity
BBH51_08275	COG3077	Addiction module antitoxin, RelB DinJ family
BBH51_08280	COG3041	Addiction module toxin RelE StbE family
BBH51_08295	COG2351	hydroxyisourate hydrolase activity
BBH51_08300	COG0825	malonyl-CoA metabolic process
BBH51_08315	COG2252	PERMEase
BBH51_08320	COG3152	Membrane
BBH51_08325	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBH51_08330	COG0375	protein maturation
BBH51_08335	COG2814	Major facilitator Superfamily
BBH51_08340	COG0563	adenylate kinase activity
BBH51_08345	COG2963	transposase activity
BBH51_08350	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BBH51_08355	COG3025	triphosphatase activity
BBH51_08360	COG1392	Phosphate transport regulator
BBH51_08365	COG0306	phosphate transporter
BBH51_08370	COG4991	sh3 domain protein
BBH51_08375	COG0617	tRNA 3'-terminal CCA addition
BBH51_08380	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BBH51_08385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BBH51_08400	COG1620	l-lactate permease
BBH51_08420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BBH51_08430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBH51_08450	COG2026	Addiction module toxin, RelE StbE family
BBH51_08510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BBH51_08520	COG1862	Preprotein translocase
BBH51_08525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBH51_08530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BBH51_08540	COG1012	belongs to the aldehyde dehydrogenase family
BBH51_08540	COG1454	alcohol dehydrogenase
BBH51_08545	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBH51_08550	COG1129	ABC transporter
BBH51_08555	COG1879	ABC-type sugar transport system periplasmic component
BBH51_08565	COG0673	inositol 2-dehydrogenase activity
BBH51_08605	COG0720	synthase
BBH51_08610	COG0602	queuosine metabolic process
BBH51_08615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBH51_08620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BBH51_08630	COG0783	Belongs to the Dps family
BBH51_08640	COG2814	Major facilitator Superfamily
BBH51_08650	COG3550	peptidyl-serine autophosphorylation
BBH51_08670	COG2927	DNA polymerase III (CHI subunit)
BBH51_08675	COG0114	fumarate hydratase activity
BBH51_08680	COG2268	Band 7 protein
BBH51_08690	COG0778	Nitroreductase
BBH51_08695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBH51_08705	COG0814	amino acid
BBH51_08740	COG0235	Class ii aldolase
BBH51_08745	COG3623	hexulose-6-phosphate isomerase
BBH51_08770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BBH51_08805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBH51_08810	COG3962	Belongs to the TPP enzyme family
BBH51_08820	COG0673	inositol 2-dehydrogenase activity
BBH51_08825	COG3722	fumarate hydratase activity
BBH51_08830	COG0246	Mannitol dehydrogenase
BBH51_08840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BBH51_08845	COG2274	protein secretion by the type I secretion system
BBH51_08850	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
BBH51_08855	COG2994	toxin metabolic process
BBH51_08865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BBH51_08880	COG2813	Specifically methylates the guanine in position
BBH51_08885	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BBH51_08890	COG0456	acetyltransferase
BBH51_08895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BBH51_08910	COG4795	General secretion pathway protein
BBH51_08915	COG2165	general secretion pathway protein
BBH51_08945	COG3064	Membrane
BBH51_08950	COG0848	biopolymer transport protein
BBH51_08955	COG0811	peptide transport
BBH51_08960	COG0824	Thioesterase
BBH51_08970	COG1294	oxidase, subunit
BBH51_08975	COG1271	oxidase subunit
BBH51_09005	COG0217	transcriptional regulatory protein
BBH51_09010	COG0494	nUDIX hydrolase
BBH51_09030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BBH51_09035	COG1755	Isoprenylcysteine carboxyl methyltransferase
BBH51_09050	COG2271	Major facilitator Superfamily
BBH51_09060	COG0346	lactoylglutathione lyase activity
BBH51_09065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBH51_09070	COG2056	Na+-H+ antiporter family
BBH51_09085	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BBH51_09090	COG0142	geranyltranstransferase activity
BBH51_09105	COG0697	spore germination
BBH51_09110	COG0697	spore germination
BBH51_09115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BBH51_09125	COG4166	transmembrane transport
BBH51_09130	COG0601	transmembrane transport
BBH51_09135	COG0601	transmembrane transport
BBH51_09140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBH51_09145	COG0444	Belongs to the ABC transporter superfamily
BBH51_09150	COG4608	Belongs to the ABC transporter superfamily
BBH51_09155	COG0745	RESPONSE REGULATOR receiver
BBH51_09160	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BBH51_09170	COG1611	Belongs to the LOG family
BBH51_09180	COG2259	Doxx family
BBH51_09190	COG1530	ribonuclease E activity
BBH51_09205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBH51_09210	COG0626	cystathionine gamma-synthase activity
BBH51_09265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BBH51_09270	COG1959	2 iron, 2 sulfur cluster binding
BBH51_09280	COG0822	iron-sulfur transferase activity
BBH51_09295	COG0443	Heat shock 70 kDa protein
BBH51_09300	COG0633	Ferredoxin
BBH51_09305	COG2975	iron-sulfur cluster assembly
BBH51_09310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBH51_09310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BBH51_09315	COG0489	protein tyrosine kinase activity
BBH51_09355	COG0590	tRNA wobble adenosine to inosine editing
BBH51_09365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BBH51_09375	COG0730	response to heat
BBH51_09385	COG1869	D-ribose catabolic process
BBH51_09395	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBH51_09400	COG1879	ABC-type sugar transport system periplasmic component
BBH51_09405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBH51_09410	COG1278	Cold shock
BBH51_09445	COG0165	Argininosuccinate lyase
BBH51_09450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBH51_09455	COG0753	catalase activity
BBH51_09475	COG0587	DNA-directed DNA polymerase activity
BBH51_09480	COG1022	Amp-dependent synthetase and ligase
BBH51_09490	COG1328	CTP reductase activity
BBH51_09490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBH51_09495	COG0602	queuosine metabolic process
BBH51_09500	COG0084	hydrolase, TatD family'
BBH51_09510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBH51_09570	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BBH51_09570	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BBH51_09575	COG0517	IMP dehydrogenase activity
BBH51_09575	COG0516	GMP reductase activity
BBH51_09580	COG2932	Transcriptional regulator
BBH51_09595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBH51_09600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BBH51_09610	COG2062	phosphohistidine phosphatase, SixA
BBH51_09625	COG3100	YcgL domain-containing protein
BBH51_09635	COG0791	NLP P60 protein
BBH51_09645	COG2890	protein-(glutamine-N5) methyltransferase activity
BBH51_09650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BBH51_09655	COG3133	Outer membrane lipoprotein
BBH51_09660	COG3102	Protein conserved in bacteria
BBH51_09670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BBH51_09675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBH51_09680	COG4178	(ABC) transporter
BBH51_09685	COG4774	siderophore transport
BBH51_09695	COG0307	riboflavin synthase, alpha
BBH51_09700	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBH51_09705	COG3657	addiction module killer protein
BBH51_09710	COG1534	Rna-binding protein
BBH51_09715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBH51_09720	COG2027	D-alanyl-D-alanine carboxypeptidase
BBH51_09730	COG0303	'Molybdopterin
BBH51_09735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BBH51_09745	COG3118	belongs to the thioredoxin family
BBH51_09750	COG0492	ferredoxin-NADP+ reductase activity
BBH51_09755	COG4988	ABC transporter
BBH51_09760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BBH51_09770	COG1946	Acyl-CoA thioesterase
BBH51_09775	COG0515	serine threonine protein kinase
BBH51_09795	COG1940	carbohydrate kinase activity
BBH51_09800	COG0671	phosphoesterase, PA-phosphatase related
BBH51_09805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BBH51_09835	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBH51_09840	COG0662	Cupin 2, conserved barrel domain protein
BBH51_09840	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BBH51_09865	COG2244	polysaccharide biosynthetic process
BBH51_09870	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BBH51_09875	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BBH51_09880	COG0708	Exodeoxyribonuclease III
BBH51_09885	COG2951	lytic endotransglycosylase activity
BBH51_09890	COG1216	Glycosyl transferase, family 2
BBH51_09895	COG1216	Glycosyl transferase, family 2
BBH51_09905	COG3306	glycosyltransferase involved in LPS biosynthesis
BBH51_09915	COG5039	Polysaccharide pyruvyl transferase
BBH51_09920	COG2161	toxin-antitoxin pair type II binding
BBH51_09925	COG4115	mRNA cleavage
BBH51_09930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BBH51_09935	COG1793	dna ligase
BBH51_09940	COG0210	DNA helicase
BBH51_09945	COG2610	gluconate transmembrane transporter activity
BBH51_09950	COG3265	gluconokinase activity
BBH51_09955	COG1609	Transcriptional regulator
BBH51_09975	COG0437	4 iron, 4 sulfur cluster binding
BBH51_09980	COG2864	formate dehydrogenase
BBH51_09985	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BBH51_09990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BBH51_09995	COG0651	ATP synthesis coupled electron transport
BBH51_10000	COG0650	Formate hydrogenlyase subunit 4
BBH51_10005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BBH51_10010	COG4237	Hydrogenase 4 membrane
BBH51_10015	COG0651	ATP synthesis coupled electron transport
BBH51_10020	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BBH51_10020	COG3261	NADH dehydrogenase
BBH51_10025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BBH51_10030	COG3260	NADH ubiquinone oxidoreductase 20
BBH51_10040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BBH51_10050	COG3383	formate dehydrogenase (NAD+) activity
BBH51_10055	COG3383	formate dehydrogenase (NAD+) activity
BBH51_10075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BBH51_10085	COG0508	dehydrogenase complex catalyzes the overall conversion of
BBH51_10090	COG0567	Dehydrogenase, E1 component
BBH51_10095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BBH51_10100	COG3108	Peptidase M15
BBH51_10105	COG2989	Protein conserved in bacteria
BBH51_10110	COG0793	Belongs to the peptidase S41A family
BBH51_10115	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
BBH51_10120	COG2995	paraquat-inducible protein a
BBH51_10125	COG3008	intermembrane lipid transfer
BBH51_10135	COG3842	ATPase activity
BBH51_10140	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBH51_10145	COG1177	transmembrane transport
BBH51_10150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBH51_10165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BBH51_10170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BBH51_10185	COG1522	sequence-specific DNA binding
BBH51_10195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BBH51_10200	COG1178	ABC-type Fe3 transport system permease component
BBH51_10205	COG4143	(ABC) transporter
BBH51_10210	COG0351	phosphomethylpyrimidine kinase
BBH51_10210	COG0351	phosphomethylpyrimidine kinase
BBH51_10255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BBH51_10270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBH51_10290	COG2920	part of a sulfur-relay system
BBH51_10300	COG1121	(ABC) transporter
BBH51_10305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBH51_10310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BBH51_10325	COG1803	Methylglyoxal synthase
BBH51_10330	COG3304	Inner membrane component domain
BBH51_10335	COG1289	transmembrane transporter activity
BBH51_10350	COG3958	Transketolase
BBH51_10355	COG3959	Transketolase, thiamine diphosphate binding domain
BBH51_10395	COG3501	Rhs element vgr protein
BBH51_10400	COG4953	penicillin-binding protein 1C
BBH51_10405	COG2855	membrane
BBH51_10420	COG0157	Belongs to the NadC ModD family
BBH51_10425	COG3842	ATPase activity
BBH51_10430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BBH51_10435	COG0725	ABC transporter, periplasmic molybdate-binding protein
BBH51_10445	COG3676	manually curated
BBH51_10450	COG5339	Protein conserved in bacteria
BBH51_10455	COG0443	Heat shock 70 kDa protein
BBH51_10460	COG0484	heat shock protein binding
BBH51_10465	COG2337	Toxic component of a toxin-antitoxin (TA) module
BBH51_10480	COG0626	cystathionine gamma-synthase activity
BBH51_10485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBH51_10505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBH51_10510	COG2999	glutathione oxidoreductase activity
BBH51_10515	COG1530	ribonuclease E activity
BBH51_10520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBH51_10570	COG1840	ABC-type Fe3 transport system, periplasmic component
BBH51_10575	COG1840	ABC-type Fe3 transport system, periplasmic component
BBH51_10600	COG2860	membrane
BBH51_10615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BBH51_10625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BBH51_10630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BBH51_10635	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BBH51_10640	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BBH51_10665	COG2914	Belongs to the UPF0125 (RnfH) family
BBH51_10670	COG2850	peptidyl-arginine hydroxylation
BBH51_10675	COG1570	exodeoxyribonuclease VII activity
BBH51_10685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BBH51_10690	COG1137	ATPase activity
BBH51_10695	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BBH51_10700	COG3117	lipopolysaccharide transmembrane transporter activity
BBH51_10705	COG1127	ABC transporter
BBH51_10710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BBH51_10715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BBH51_10720	COG2854	intermembrane phospholipid transfer
BBH51_10725	COG3113	response to antibiotic
BBH51_10730	COG5007	Belongs to the BolA IbaG family
BBH51_10740	COG3691	Protein conserved in bacteria
BBH51_10750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBH51_10760	COG0861	Integral membrane protein TerC family
BBH51_10775	COG3468	outer membrane autotransporter barrel domain protein
BBH51_10775	COG3266	domain, Protein
BBH51_10780	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BBH51_10785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BBH51_10800	COG1125	glycine betaine transport
BBH51_10800	COG0517	IMP dehydrogenase activity
BBH51_10805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBH51_10815	COG0460	homoserine dehydrogenase
BBH51_10815	COG0527	aspartate kinase activity
BBH51_10830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BBH51_10835	COG2091	lysine biosynthetic process via aminoadipic acid
BBH51_10840	COG0330	HflC and HflK could
BBH51_10845	COG0330	HflC and HflK could
BBH51_10850	COG0544	peptidyl-prolyl cis-trans isomerase activity
BBH51_10855	COG4974	Belongs to the 'phage' integrase family
BBH51_10860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBH51_10875	COG3061	Opacity-associated protein A
BBH51_10875	COG3266	domain, Protein
BBH51_10880	COG1509	lysine 2,3-aminomutase activity
BBH51_10890	COG3033	Beta-eliminating lyase
BBH51_10895	COG0814	amino acid
BBH51_10900	COG2964	Protein conserved in bacteria
BBH51_10905	COG5413	integral membrane protein
BBH51_10915	COG0204	Acyl-transferase
BBH51_10925	COG0697	spore germination
BBH51_10930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BBH51_10935	COG1882	Formate acetyltransferase
BBH51_10940	COG2116	formate transmembrane transporter activity
BBH51_10945	COG0537	adenosine 5'-monophosphoramidase activity
BBH51_10985	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BBH51_11000	COG0681	Belongs to the peptidase S26 family
BBH51_11030	COG0230	Belongs to the bacterial ribosomal protein bL34 family