locus-tag	class	description
N7761_00010	COG0351	phosphomethylpyrimidine kinase
N7761_00020	COG1518	maintenance of DNA repeat elements
N7761_00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N7761_00060	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
N7761_00065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N7761_00070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N7761_00085	COG0405	Gamma-glutamyltransferase
N7761_00090	COG0642	Histidine kinase
N7761_00105	COG3392	D12 class N6 adenine-specific DNA methyltransferase
N7761_00130	COG3111	PFAM Bacterial OB fold (BOF) protein
N7761_00145	COG4607	ABC-type enterochelin transport system periplasmic component
N7761_00150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7761_00155	COG4605	iron ion homeostasis
N7761_00160	COG4604	ABC transporter, ATP-binding protein
N7761_00165	COG0739	heme binding
N7761_00175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N7761_00180	COG0733	neurotransmitter:sodium symporter activity
N7761_00185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N7761_00215	COG4657	Part of a membrane complex involved in electron transport
N7761_00220	COG1090	epimerase
N7761_00225	COG1438	arginine binding
N7761_00230	COG0039	L-malate dehydrogenase activity
N7761_00240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N7761_00245	COG0583	DNA-binding transcription factor activity
N7761_00255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N7761_00260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N7761_00260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N7761_00265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N7761_00275	COG0471	metal ion transport
N7761_00280	COG2005	Transcriptional regulator
N7761_00285	COG0725	ABC transporter, periplasmic molybdate-binding protein
N7761_00290	COG4149	molybdate abc transporter
N7761_00295	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
N7761_00300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N7761_00305	COG0795	lipopolysaccharide-transporting ATPase activity
N7761_00310	COG0795	lipopolysaccharide-transporting ATPase activity
N7761_00315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N7761_00320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N7761_00330	COG0309	Hydrogenase expression formation protein (HypE)
N7761_00335	COG0409	Hydrogenase expression formation protein
N7761_00340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N7761_00345	COG1122	ATPase activity
N7761_00350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N7761_00355	COG0310	cobalt ion transport
N7761_00360	COG0310	cobalt ion transport
N7761_00365	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
N7761_00370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N7761_00375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7761_00380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N7761_00385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7761_00395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N7761_00400	COG0720	synthase
N7761_00405	COG0602	queuosine metabolic process
N7761_00410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N7761_00415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N7761_00425	COG0783	Belongs to the Dps family
N7761_00430	COG1566	PFAM secretion protein HlyD family protein
N7761_00435	COG2814	Major facilitator Superfamily
N7761_00445	COG3550	peptidyl-serine autophosphorylation
N7761_00480	COG2927	DNA polymerase III (CHI subunit)
N7761_00485	COG0114	fumarate hydratase activity
N7761_00490	COG2268	Band 7 protein
N7761_00505	COG0778	Nitroreductase
N7761_00510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N7761_00520	COG0814	amino acid
N7761_00525	COG0235	Class ii aldolase
N7761_00530	COG3623	hexulose-6-phosphate isomerase
N7761_00555	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N7761_00560	COG4953	penicillin-binding protein 1C
N7761_00565	COG2855	membrane
N7761_00585	COG3842	ATPase activity
N7761_00590	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
N7761_00600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N7761_00605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N7761_00615	COG0307	riboflavin synthase, alpha
N7761_00620	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N7761_00625	COG3657	addiction module killer protein
N7761_00630	COG1534	Rna-binding protein
N7761_00635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N7761_00640	COG2027	D-alanyl-D-alanine carboxypeptidase
N7761_00650	COG0303	'Molybdopterin
N7761_00655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N7761_00665	COG4580	involved in the transport of maltose and maltodextrins
N7761_00670	COG3842	ATPase activity
N7761_00675	COG2182	Extracellular solute-binding protein
N7761_00685	COG3833	ABC-type maltose transport systems, permease component
N7761_00690	COG0366	Alpha amylase catalytic
N7761_00695	COG3842	ATPase activity
N7761_00705	COG1840	ABC-type Fe3 transport system, periplasmic component
N7761_00715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N7761_00730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N7761_00740	COG0633	Ferredoxin
N7761_00750	COG1280	lysine exporter protein (LysE YggA)
N7761_00755	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N7761_00760	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N7761_00770	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N7761_00775	COG0166	Belongs to the GPI family
N7761_00785	COG0305	Participates in initiation and elongation during chromosome replication
N7761_00790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N7761_00795	COG4591	ABC-type transport system involved in lipoprotein release permease component
N7761_00805	COG4591	ABC-type transport system involved in lipoprotein release permease component
N7761_00810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N7761_00815	COG0512	Glutamine amidotransferase of anthranilate synthase
N7761_00825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N7761_00830	COG4166	transmembrane transport
N7761_00835	COG2832	Protein of unknown function (DUF454)
N7761_00840	COG0339	signal peptide processing
N7761_00845	COG2190	(PTS) system
N7761_00850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N7761_00855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_00875	COG2194	sulfuric ester hydrolase activity
N7761_00885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N7761_00895	COG2246	polysaccharide biosynthetic process
N7761_00905	COG0802	atpase or kinase
N7761_00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
N7761_00910	COG1388	LysM domain
N7761_00915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N7761_00925	COG1923	regulation of RNA biosynthetic process
N7761_00935	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N7761_00945	COG3106	COG3106 Predicted ATPase
N7761_00950	COG4166	transmembrane transport
N7761_00955	COG4168	peptide transport system, permease
N7761_00960	COG4171	peptide transport system, permease
N7761_00965	COG4172	Belongs to the ABC transporter superfamily
N7761_00970	COG4172	Belongs to the ABC transporter superfamily
N7761_01000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N7761_01010	COG0251	oxidation-reduction process
N7761_01015	COG2137	regulation of response to DNA damage stimulus
N7761_01020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N7761_01030	COG2095	MarC family integral membrane protein
N7761_01055	COG2963	transposase activity
N7761_01065	COG1349	DNA-binding transcription factor activity
N7761_01075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N7761_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
N7761_01110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N7761_01115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N7761_01120	COG0765	amino acid transport
N7761_01125	COG1126	abc transporter atp-binding protein
N7761_01130	COG2168	tRNA wobble position uridine thiolation
N7761_01140	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N7761_01145	COG2964	Protein conserved in bacteria
N7761_01150	COG0545	Peptidyl-prolyl cis-trans isomerase
N7761_01155	COG2900	Belongs to the SlyX family
N7761_01160	COG0678	peroxiredoxin activity
N7761_01160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N7761_01165	COG0583	DNA-binding transcription factor activity
N7761_01170	COG1309	transcriptional regulator
N7761_01175	COG1132	(ABC) transporter
N7761_01180	COG4988	ABC transporter
N7761_01185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N7761_01190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N7761_01195	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N7761_01205	COG1045	serine acetyltransferase
N7761_01210	COG1494	fructose-1,6-bisphosphatase
N7761_01220	COG0716	FMN binding
N7761_01230	COG0702	epimerase
N7761_01235	COG1733	regulation of RNA biosynthetic process
N7761_01245	COG3312	ion transport
N7761_01265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N7761_01275	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N7761_01290	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N7761_01310	COG0732	type I restriction modification DNA specificity domain
N7761_01320	COG3716	PTS system mannose fructose sorbose family IID component
N7761_01325	COG3715	PTS system
N7761_01330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N7761_01330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_01335	COG2814	Major facilitator Superfamily
N7761_01340	COG2207	Transcriptional regulator
N7761_01340	COG1609	Transcriptional regulator
N7761_01345	COG1757	Na H antiporter
N7761_01350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N7761_01355	COG4214	carbohydrate transport
N7761_01360	COG1129	ABC transporter
N7761_01365	COG4213	ABC transporter substrate-binding protein
N7761_01370	COG2115	Belongs to the xylose isomerase family
N7761_01375	COG1070	Carbohydrate kinase
N7761_01395	COG2801	Transposase and inactivated derivatives
N7761_01400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N7761_01405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N7761_01410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N7761_01415	COG3719	Belongs to the RNase T2 family
N7761_01425	COG0191	fructose-bisphosphate aldolase activity
N7761_01430	COG3307	-O-antigen
N7761_01435	COG2267	carboxylic ester hydrolase activity
N7761_01440	COG0561	phosphatase activity
N7761_01455	COG2177	Part of the ABC transporter FtsEX involved in
N7761_01460	COG2884	Cell division ATP-binding protein ftsE
N7761_01470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N7761_01500	COG1238	metal cluster binding
N7761_01510	COG4942	peptidase
N7761_01510	COG1388	LysM domain
N7761_01520	COG0463	Glycosyl transferase, family 2
N7761_01525	COG1519	Transferase
N7761_01540	COG0859	PFAM glycosyl transferase family 9
N7761_01545	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N7761_01550	COG4977	sequence-specific DNA binding
N7761_01550	COG1917	Cupin 2, conserved barrel domain protein
N7761_01555	COG1132	(ABC) transporter
N7761_01590	COG0758	DNA mediated transformation
N7761_01595	COG0584	glycerophosphoryl diester phosphodiesterase
N7761_01600	COG2271	Major facilitator Superfamily
N7761_01610	COG0557	exoribonuclease II activity
N7761_01615	COG1077	Cell shape determining protein MreB Mrl
N7761_01620	COG1792	Involved in formation and maintenance of cell shape
N7761_01625	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N7761_01650	COG0006	proline dipeptidase activity
N7761_01670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N7761_01685	COG1496	oxidoreductase activity
N7761_01690	COG1368	sulfuric ester hydrolase activity
N7761_01695	COG0778	Nitroreductase
N7761_01705	COG0762	integral membrane protein
N7761_01715	COG0500	methyltransferase
N7761_01720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N7761_01725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7761_01730	COG1309	transcriptional regulator
N7761_01735	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N7761_01740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N7761_01755	COG3306	glycosyltransferase involved in LPS biosynthesis
N7761_01765	COG3306	glycosyltransferase involved in LPS biosynthesis
N7761_01800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N7761_01810	COG1309	transcriptional regulator
N7761_01825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N7761_01830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N7761_01835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N7761_01840	COG4972	Pilus assembly protein
N7761_01860	COG4796	Type ii and iii secretion system protein
N7761_01875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N7761_01885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N7761_01895	COG2801	Transposase and inactivated derivatives
N7761_01900	COG0789	Transcriptional regulator
N7761_01905	COG4701	Protein of unknown function (DUF721)
N7761_01920	COG0494	nUDIX hydrolase
N7761_01925	COG1466	dna polymerase III delta subunit
N7761_01930	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N7761_01945	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N7761_01950	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N7761_01955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N7761_01960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N7761_01965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N7761_01985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N7761_02005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
N7761_02010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N7761_02020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N7761_02025	COG4137	Cytochrome C assembly protein
N7761_02030	COG4536	flavin adenine dinucleotide binding
N7761_02035	COG0811	peptide transport
N7761_02040	COG0848	biopolymer transport protein
N7761_02080	COG0243	molybdopterin cofactor binding
N7761_02085	COG0437	4 iron, 4 sulfur cluster binding
N7761_02090	COG3302	dmso reductase anchor subunit
N7761_02095	COG3381	protein complex oligomerization
N7761_02100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N7761_02100	COG2221	Nitrite and sulphite reductase 4Fe-4S
N7761_02110	COG4545	Glutaredoxin-related protein
N7761_02135	COG0805	protein transport
N7761_02140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N7761_02145	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N7761_02150	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N7761_02155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N7761_02160	COG1011	Hydrolase
N7761_02165	COG0494	nUDIX hydrolase
N7761_02180	COG3059	membrane
N7761_02185	COG1297	OPT oligopeptide transporter protein
N7761_02195	COG1218	3'(2'),5'-bisphosphate nucleotidase
N7761_02200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N7761_02205	COG0363	glucosamine-6-phosphate deaminase activity
N7761_02215	COG1794	racemase activity, acting on amino acids and derivatives
N7761_02220	COG4545	Glutaredoxin-related protein
N7761_02235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N7761_02240	COG1028	Short-chain dehydrogenase reductase Sdr
N7761_02250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N7761_02305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N7761_02330	COG1011	Hydrolase
N7761_02340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N7761_02345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N7761_02365	COG1596	polysaccharide export
N7761_02365	COG1555	photosystem II stabilization
N7761_02370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N7761_02375	COG0561	phosphatase activity
N7761_02380	COG1040	competence protein
N7761_02395	COG1114	Component of the transport system for branched-chain amino acids
N7761_02420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N7761_02430	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N7761_02440	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N7761_02460	COG0201	protein transport
N7761_02480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N7761_02500	COG0814	amino acid
N7761_02505	COG2129	metallophosphoesterase
N7761_02510	COG3172	ATPase kinase involved in NAD metabolism
N7761_02530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N7761_02535	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N7761_02575	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N7761_02585	COG2801	Transposase and inactivated derivatives
N7761_02595	COG2364	Membrane
N7761_02605	COG0859	PFAM glycosyl transferase family 9
N7761_02610	COG1027	Aspartate ammonia-lyase
N7761_02620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N7761_02625	COG0459	protein refolding
N7761_02645	COG2801	Transposase and inactivated derivatives
N7761_02655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N7761_02660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N7761_02665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N7761_02670	COG1381	Involved in DNA repair and RecF pathway recombination
N7761_02675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N7761_02690	COG0354	folic acid binding
N7761_02695	COG1561	YicC-like family, N-terminal region
N7761_02705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N7761_02720	COG3842	ATPase activity
N7761_02725	COG1178	ABC-type Fe3 transport system permease component
N7761_02730	COG1840	ABC-type Fe3 transport system, periplasmic component
N7761_02735	COG3171	Protein conserved in bacteria
N7761_02745	COG1194	a g-specific adenine glycosylase
N7761_02770	COG3056	Lipoprotein
N7761_02775	COG0271	Belongs to the BolA IbaG family
N7761_02790	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N7761_02795	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N7761_02800	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N7761_02805	COG2871	sodium ion transport
N7761_02810	COG1477	protein flavinylation
N7761_02815	COG2991	Protein conserved in bacteria
N7761_02825	COG0148	phosphopyruvate hydratase activity
N7761_02840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N7761_02845	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N7761_02850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N7761_02860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N7761_02875	COG3956	TIGRFAM MazG family protein
N7761_02880	COG0402	S-adenosylhomocysteine deaminase activity
N7761_02885	COG3083	sulfuric ester hydrolase activity
N7761_02890	COG3082	Protein of unknown function (DUF1414)
N7761_02900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N7761_02905	COG0745	RESPONSE REGULATOR receiver
N7761_02910	COG2205	protein histidine kinase activity
N7761_02915	COG0786	glutamate:sodium symporter activity
N7761_02930	COG3012	SEC-C Motif Domain Protein
N7761_02935	COG2258	MOSC domain
N7761_02940	COG0433	COG0433 Predicted ATPase
N7761_02955	COG0656	L-ascorbic acid biosynthetic process
N7761_02960	COG0667	Aldo Keto reductase
N7761_02965	COG2272	Belongs to the type-B carboxylesterase lipase family
N7761_02990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N7761_02995	COG1349	DNA-binding transcription factor activity
N7761_03005	COG3068	Protein conserved in bacteria
N7761_03010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N7761_03030	COG0248	Ppx GppA phosphatase
N7761_03035	COG2911	Protein conserved in bacteria
N7761_03040	COG0729	surface antigen
N7761_03045	COG2197	response regulator
N7761_03055	COG0181	hydroxymethylbilane synthase activity
N7761_03065	COG2959	enzyme of heme biosynthesis
N7761_03070	COG3071	HemY protein
N7761_03075	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N7761_03085	COG1595	DNA-templated transcription, initiation
N7761_03095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N7761_03110	COG0471	metal ion transport
N7761_03115	COG0583	DNA-binding transcription factor activity
N7761_03120	COG2183	response to ionizing radiation
N7761_03130	COG1172	Belongs to the binding-protein-dependent transport system permease family
N7761_03135	COG1129	ABC transporter
N7761_03140	COG1879	ABC-type sugar transport system periplasmic component
N7761_03145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N7761_03170	COG1072	(Pantothenic acid kinase))
N7761_03175	COG0187	DNA topoisomerase II activity
N7761_03180	COG0514	ATP-dependent DNA helicase (RecQ)
N7761_03195	COG0019	diaminopimelate decarboxylase activity
N7761_03200	COG3477	response to acidic pH
N7761_03205	COG2818	Glycosylase
N7761_03210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N7761_03220	COG2195	Cleaves the N-terminal amino acid of tripeptides
N7761_03225	COG0300	oxidoreductase activity
N7761_03230	COG1763	Mo-molybdopterin cofactor biosynthetic process
N7761_03235	COG3086	response to oxidative stress
N7761_03240	COG3026	antisigma factor binding
N7761_03245	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
N7761_03250	COG1595	DNA-templated transcription, initiation
N7761_03265	COG0442	prolyl-tRNA aminoacylation
N7761_03270	COG1921	L-seryl-tRNASec selenium transferase activity
N7761_03275	COG3276	selenocysteine insertion sequence binding
N7761_03285	COG1285	pathogenesis
N7761_03295	COG0733	neurotransmitter:sodium symporter activity
N7761_03360	COG4964	Belongs to the GSP D family
N7761_03385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N7761_03395	COG1444	tRNA N-acetyltransferase activity
N7761_03405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N7761_03415	COG1126	abc transporter atp-binding protein
N7761_03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N7761_03425	COG4215	(ABC) transporter
N7761_03430	COG4160	amino acid transport
N7761_03435	COG1966	Carbon starvation protein
N7761_03450	COG3116	cell division
N7761_03455	COG0768	penicillin binding
N7761_03465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N7761_03475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N7761_03485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N7761_03500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N7761_03505	COG0849	cell division
N7761_03510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N7761_03520	COG1605	Chorismate mutase
N7761_03520	COG0077	Prephenate dehydratase
N7761_03525	COG0326	Molecular chaperone. Has ATPase activity
N7761_03530	COG1393	Belongs to the ArsC family
N7761_03540	COG1876	peptidase activity
N7761_03545	COG0494	nUDIX hydrolase
N7761_03550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N7761_03595	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N7761_03605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N7761_03610	COG1053	succinate dehydrogenase
N7761_03620	COG1120	ATPase activity
N7761_03625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7761_03630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7761_03635	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
N7761_03640	COG1408	metallophosphoesterase
N7761_03650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N7761_03655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N7761_03675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N7761_03685	COG0741	lytic transglycosylase activity
N7761_03690	COG2350	Protein conserved in bacteria
N7761_03695	COG1607	acyl-coa hydrolase
N7761_03710	COG3047	cAMP biosynthetic process
N7761_03715	COG0497	DNA recombination
N7761_03725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N7761_03735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N7761_03735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N7761_03740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N7761_03745	COG2198	Histidine kinase
N7761_03745	COG0784	Response regulator, receiver
N7761_03745	COG5002	protein histidine kinase activity
N7761_03750	COG4211	Belongs to the binding-protein-dependent transport system permease family
N7761_03760	COG1879	ABC-type sugar transport system periplasmic component
N7761_03765	COG1609	Transcriptional regulator
N7761_03770	COG1085	galactose-1-phosphate uridylyltransferase
N7761_03775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N7761_03780	COG2017	converts alpha-aldose to the beta-anomer
N7761_03800	COG0471	metal ion transport
N7761_03805	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N7761_03805	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
N7761_03810	COG3051	citrate lyase alpha subunit
N7761_03815	COG2301	Belongs to the HpcH HpaI aldolase family
N7761_03825	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N7761_03830	COG4535	Mg2 and Co2 transporter CorC
N7761_03850	COG0105	UTP biosynthetic process
N7761_03860	COG0489	protein tyrosine kinase activity
N7761_03865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N7761_03865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N7761_03870	COG2975	iron-sulfur cluster assembly
N7761_03875	COG0633	Ferredoxin
N7761_03880	COG0443	Heat shock 70 kDa protein
N7761_03895	COG0822	iron-sulfur transferase activity
N7761_03905	COG1959	2 iron, 2 sulfur cluster binding
N7761_03910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N7761_03935	COG1840	ABC-type Fe3 transport system, periplasmic component
N7761_03940	COG1840	ABC-type Fe3 transport system, periplasmic component
N7761_03990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N7761_03995	COG1530	ribonuclease E activity
N7761_04000	COG2999	glutathione oxidoreductase activity
N7761_04005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N7761_04080	COG3021	interspecies interaction between organisms
N7761_04115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N7761_04120	COG0626	cystathionine gamma-synthase activity
N7761_04135	COG2337	Toxic component of a toxin-antitoxin (TA) module
N7761_04140	COG0484	heat shock protein binding
N7761_04145	COG0443	Heat shock 70 kDa protein
N7761_04150	COG5339	Protein conserved in bacteria
N7761_04160	COG3102	Protein conserved in bacteria
N7761_04165	COG3133	Outer membrane lipoprotein
N7761_04170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N7761_04175	COG2890	protein-(glutamine-N5) methyltransferase activity
N7761_04185	COG0791	NLP P60 protein
N7761_04190	COG3100	YcgL domain-containing protein
N7761_04205	COG2062	phosphohistidine phosphatase, SixA
N7761_04215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N7761_04220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N7761_04235	COG0529	Catalyzes the synthesis of activated sulfate
N7761_04255	COG0516	GMP reductase activity
N7761_04255	COG0517	IMP dehydrogenase activity
N7761_04260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N7761_04260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N7761_04300	COG0521	Mo-molybdopterin cofactor biosynthetic process
N7761_04310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N7761_04315	COG0490	domain, Protein
N7761_04315	COG0471	metal ion transport
N7761_04325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N7761_04345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N7761_04360	COG0575	Belongs to the CDS family
N7761_04375	COG0233	cytoplasmic translational termination
N7761_04390	COG4178	(ABC) transporter
N7761_04400	COG1349	DNA-binding transcription factor activity
N7761_04405	COG0705	Rhomboid family
N7761_04430	COG0551	DNA topoisomerase type I activity
N7761_04445	COG2962	Rard protein
N7761_04450	COG0583	DNA-binding transcription factor activity
N7761_04460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N7761_04475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N7761_04480	COG3070	regulator of competence-specific genes
N7761_04485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N7761_04495	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N7761_04500	COG3850	Histidine kinase
N7761_04505	COG3062	negative regulation of establishment of protein localization
N7761_04510	COG0243	molybdopterin cofactor binding
N7761_04515	COG0437	4 iron, 4 sulfur cluster binding
N7761_04520	COG0348	domain, Protein
N7761_04525	COG3043	anaerobic respiration
N7761_04530	COG3005	denitrification pathway
N7761_04535	COG0754	glutathionylspermidine amidase activity
N7761_04540	COG0859	PFAM glycosyl transferase family 9
N7761_04550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N7761_04560	COG0737	Belongs to the 5'-nucleotidase family
N7761_04575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N7761_04575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N7761_04585	COG5645	(Lipo)protein
N7761_04590	COG0210	DNA helicase
N7761_04615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N7761_04620	COG0110	maltose O-acetyltransferase activity
N7761_04625	COG1238	metal cluster binding
N7761_04645	COG3201	nicotinamide mononucleotide transporter
N7761_04655	COG0513	Belongs to the DEAD box helicase family
N7761_04685	COG2271	Major facilitator Superfamily
N7761_04695	COG1215	transferase activity, transferring glycosyl groups
N7761_04700	COG1649	PFAM Uncharacterised BCR, COG1649
N7761_04700	COG0726	polysaccharide deacetylase
N7761_04715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N7761_04720	COG0561	phosphatase activity
N7761_04725	COG3716	PTS system mannose fructose sorbose family IID component
N7761_04730	COG3715	PTS system
N7761_04735	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N7761_04735	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_04740	COG0742	ribosomal rna small subunit methyltransferase
N7761_04745	COG0552	protein localization to endoplasmic reticulum
N7761_04755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N7761_04760	COG4783	chaperone-mediated protein folding
N7761_04770	COG0814	amino acid
N7761_04795	COG0747	negative chemotaxis
N7761_04800	COG2853	Lipoprotein
N7761_04815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N7761_04820	COG4942	peptidase
N7761_04825	COG2861	carbohydrate metabolic process
N7761_04900	COG3501	Rhs element vgr protein
N7761_04920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N7761_04950	COG2990	Protein conserved in bacteria
N7761_04955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N7761_04975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N7761_05015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N7761_05015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N7761_05020	COG0569	domain protein
N7761_05030	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
N7761_05045	COG2841	Protein conserved in bacteria
N7761_05055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N7761_05060	COG3036	rescue of stalled ribosome
N7761_05070	COG1393	Belongs to the ArsC family
N7761_05080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N7761_05085	COG1522	sequence-specific DNA binding
N7761_05095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N7761_05100	COG0038	chloride channel
N7761_05105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N7761_05110	COG0549	Belongs to the carbamate kinase family
N7761_05115	COG1288	antiporter activity
N7761_05125	COG0183	Belongs to the thiolase family
N7761_05130	COG2031	fatty acid transporter
N7761_05135	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N7761_05140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
N7761_05145	COG0583	DNA-binding transcription factor activity
N7761_05150	COG0051	transcription antitermination factor activity, RNA binding
N7761_05155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N7761_05160	COG0088	Forms part of the polypeptide exit tunnel
N7761_05165	COG0089	rRNA binding
N7761_05170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N7761_05175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N7761_05180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N7761_05185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N7761_05190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N7761_05195	COG0255	Belongs to the universal ribosomal protein uL29 family
N7761_05200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N7761_05225	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N7761_05245	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N7761_05280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
N7761_05280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N7761_05280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N7761_05285	COG1105	Belongs to the carbohydrate kinase PfkB family
N7761_05290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_05290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_05300	COG0746	molybdenum cofactor guanylyltransferase activity
N7761_05305	COG3084	Protein conserved in bacteria
N7761_05310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N7761_05315	COG3085	chromosome segregation
N7761_05340	COG0561	phosphatase activity
N7761_05350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N7761_05360	COG2610	gluconate transmembrane transporter activity
N7761_05365	COG3622	Belongs to the hyi family
N7761_05370	COG0235	Class ii aldolase
N7761_05380	COG2084	Dehydrogenase
N7761_05385	COG1349	DNA-binding transcription factor activity
N7761_05390	COG0347	Belongs to the P(II) protein family
N7761_05395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N7761_05400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N7761_05405	COG0470	DNA polymerase III
N7761_05410	COG0084	hydrolase, TatD family'
N7761_05420	COG1253	flavin adenine dinucleotide binding
N7761_05425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N7761_05430	COG3610	response to peptide
N7761_05435	COG2966	Psort location CytoplasmicMembrane, score
N7761_05445	COG0545	Peptidyl-prolyl cis-trans isomerase
N7761_05450	COG0688	phosphatidylethanolamine metabolic process
N7761_05455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N7761_05465	COG2830	Protein of unknown function (DUF452)
N7761_05470	COG0500	methyltransferase
N7761_05480	COG1399	metal-binding, possibly nucleic acid-binding protein
N7761_05490	COG0416	fatty acid biosynthetic process
N7761_05500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N7761_05505	COG1028	Short-chain dehydrogenase reductase Sdr
N7761_05515	COG2814	Major facilitator Superfamily
N7761_05520	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N7761_05525	COG0513	Belongs to the DEAD box helicase family
N7761_05530	COG0799	negative regulation of ribosome biogenesis
N7761_05540	COG0768	penicillin binding
N7761_05545	COG0772	Belongs to the SEDS family
N7761_05550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N7761_05550	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N7761_05555	COG1686	Belongs to the peptidase S11 family
N7761_05580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N7761_05595	COG0084	hydrolase, TatD family'
N7761_05600	COG0602	queuosine metabolic process
N7761_05605	COG1328	CTP reductase activity
N7761_05605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N7761_05615	COG1022	Amp-dependent synthetase and ligase
N7761_05620	COG0587	DNA-directed DNA polymerase activity
N7761_05630	COG0753	catalase activity
N7761_05635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N7761_05640	COG0165	Argininosuccinate lyase
N7761_05675	COG1278	Cold shock
N7761_05680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N7761_05685	COG1879	ABC-type sugar transport system periplasmic component
N7761_05700	COG1869	D-ribose catabolic process
N7761_05710	COG0730	response to heat
N7761_05725	COG0590	tRNA wobble adenosine to inosine editing
N7761_05730	COG3078	GTPase activator activity
N7761_05740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N7761_05745	COG0456	acetyltransferase
N7761_05755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N7761_05780	COG0511	ligase activity, forming carbon-carbon bonds
N7761_05785	COG0439	Biotin carboxylase
N7761_05800	COG4783	chaperone-mediated protein folding
N7761_05805	COG3924	membrane
N7761_05810	COG4145	pantothenate transmembrane transporter activity
N7761_05815	COG2184	nucleotidyltransferase activity
N7761_05840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N7761_05845	COG1115	amino acid carrier protein
N7761_05855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N7761_05860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N7761_05860	COG0237	dephospho-CoA kinase activity
N7761_05870	COG1459	type II secretion system
N7761_05880	COG4969	Belongs to the N-Me-Phe pilin family
N7761_05885	COG3023	N-Acetylmuramoyl-L-alanine amidase
N7761_05890	COG2731	YhcH YjgK YiaL family protein
N7761_05900	COG4785	May be involved in cell division
N7761_05905	COG0513	Belongs to the DEAD box helicase family
N7761_05920	COG3835	regulator
N7761_05925	COG2610	gluconate transmembrane transporter activity
N7761_05930	COG1929	Belongs to the glycerate kinase type-1 family
N7761_05935	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N7761_05940	COG0312	modulator of DNA gyrase
N7761_05945	COG3028	Belongs to the UPF0307 family
N7761_05960	COG1575	Belongs to the MenA family. Type 1 subfamily
N7761_05965	COG1720	tRNA m6t6A37 methyltransferase activity
N7761_05980	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N7761_05985	COG0789	Transcriptional regulator
N7761_05990	COG2608	mercury ion transmembrane transporter activity
N7761_05995	COG2217	Heavy metal translocating P-type atpase
N7761_06000	COG3739	integral membrane protein
N7761_06020	COG0740	serine-type endopeptidase activity
N7761_06025	COG2194	sulfuric ester hydrolase activity
N7761_06030	COG2918	glutathione biosynthetic process
N7761_06030	COG1181	Belongs to the D-alanine--D-alanine ligase family
N7761_06035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N7761_06040	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N7761_06045	COG2233	PERMEase
N7761_06050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N7761_06060	COG2976	Protein conserved in bacteria
N7761_06075	COG1426	Protein conserved in bacteria
N7761_06080	COG3063	Type IV pilus biogenesis stability protein PilW
N7761_06090	COG0252	asparaginase activity
N7761_06095	COG1760	l-serine dehydratase
N7761_06100	COG0814	amino acid
N7761_06105	COG3091	SprT-like family
N7761_06120	COG2267	carboxylic ester hydrolase activity
N7761_06125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N7761_06135	COG0436	Aminotransferase
N7761_06150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N7761_06160	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N7761_06165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N7761_06180	COG2321	neutral zinc metallopeptidase
N7761_06195	COG0281	malic enzyme
N7761_06195	COG0280	phosphate acetyltransferase
N7761_06210	COG4133	protoheme IX ABC transporter activity
N7761_06215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N7761_06220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N7761_06225	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N7761_06235	COG1138	Cytochrome C-type biogenesis protein
N7761_06270	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N7761_06275	COG0437	4 iron, 4 sulfur cluster binding
N7761_06280	COG3301	Polysulphide reductase, NrfD
N7761_06285	COG1138	Cytochrome C-type biogenesis protein
N7761_06290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N7761_06295	COG4235	cytochrome complex assembly
N7761_06295	COG3088	subunit of a heme lyase
N7761_06300	COG2081	HI0933 family
N7761_06305	COG0281	malic enzyme
N7761_06315	COG2801	Transposase and inactivated derivatives
N7761_06330	COG2226	methyltransferase
N7761_06340	COG0592	DNA-directed DNA polymerase activity
N7761_06345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N7761_06385	COG0681	Belongs to the peptidase S26 family
N7761_06400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N7761_06440	COG0537	adenosine 5'-monophosphoramidase activity
N7761_06445	COG2116	formate transmembrane transporter activity
N7761_06450	COG1882	Formate acetyltransferase
N7761_06455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N7761_06460	COG0697	spore germination
N7761_06470	COG0204	Acyl-transferase
N7761_06480	COG5413	integral membrane protein
N7761_06485	COG2964	Protein conserved in bacteria
N7761_06490	COG0814	amino acid
N7761_06495	COG3033	Beta-eliminating lyase
N7761_06505	COG1509	lysine 2,3-aminomutase activity
N7761_06510	COG3266	domain, Protein
N7761_06510	COG3061	Opacity-associated protein A
N7761_06530	COG2814	Major facilitator Superfamily
N7761_06535	COG4974	Belongs to the 'phage' integrase family
N7761_06550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N7761_06565	COG0196	riboflavin kinase activity
N7761_06570	COG0728	peptidoglycan biosynthetic process
N7761_06585	COG0560	Phosphoserine phosphatase
N7761_06595	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
N7761_06600	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N7761_06605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N7761_06610	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N7761_06620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N7761_06665	COG0626	cystathionine gamma-synthase activity
N7761_06670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N7761_06685	COG1530	ribonuclease E activity
N7761_06695	COG2259	Doxx family
N7761_06705	COG1611	Belongs to the LOG family
N7761_06715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N7761_06720	COG0745	RESPONSE REGULATOR receiver
N7761_06725	COG4608	Belongs to the ABC transporter superfamily
N7761_06730	COG0444	Belongs to the ABC transporter superfamily
N7761_06735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N7761_06740	COG0601	transmembrane transport
N7761_06745	COG4166	transmembrane transport
N7761_06755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N7761_06760	COG0697	spore germination
N7761_06765	COG0697	spore germination
N7761_06780	COG0142	geranyltranstransferase activity
N7761_06785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N7761_06795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N7761_06810	COG2056	Na+-H+ antiporter family
N7761_06815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N7761_06820	COG0346	lactoylglutathione lyase activity
N7761_06830	COG2271	Major facilitator Superfamily
N7761_06845	COG1755	Isoprenylcysteine carboxyl methyltransferase
N7761_06850	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N7761_06860	COG0494	nUDIX hydrolase
N7761_06865	COG0217	transcriptional regulatory protein
N7761_06870	COG0641	radical SAM
N7761_06895	COG1271	oxidase subunit
N7761_06900	COG1294	oxidase, subunit
N7761_06915	COG0824	Thioesterase
N7761_06920	COG0811	peptide transport
N7761_06925	COG0848	biopolymer transport protein
N7761_06930	COG3064	Membrane
N7761_06955	COG4795	General secretion pathway protein
N7761_07070	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N7761_07075	COG0456	acetyltransferase
N7761_07080	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
N7761_07085	COG2813	Specifically methylates the guanine in position
N7761_07100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N7761_07110	COG2994	toxin metabolic process
N7761_07115	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
N7761_07120	COG2274	protein secretion by the type I secretion system
N7761_07125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7761_07135	COG0246	Mannitol dehydrogenase
N7761_07140	COG3722	fumarate hydratase activity
N7761_07145	COG0673	inositol 2-dehydrogenase activity
N7761_07155	COG3962	Belongs to the TPP enzyme family
N7761_07160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N7761_07170	COG3718	enzyme involved in inositol metabolism
N7761_07180	COG2271	Major facilitator Superfamily
N7761_07190	COG0673	inositol 2-dehydrogenase activity
N7761_07205	COG1129	ABC transporter
N7761_07210	COG1172	Belongs to the binding-protein-dependent transport system permease family
N7761_07215	COG1454	alcohol dehydrogenase
N7761_07215	COG1012	belongs to the aldehyde dehydrogenase family
N7761_07225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N7761_07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N7761_07235	COG1862	Preprotein translocase
N7761_07245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N7761_07255	COG0826	peptidase U32
N7761_07270	COG2026	Addiction module toxin, RelE StbE family
N7761_07290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N7761_07295	COG0328	RNA-DNA hybrid ribonuclease activity
N7761_07300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N7761_07320	COG1620	l-lactate permease
N7761_07340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N7761_07345	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N7761_07350	COG0617	tRNA 3'-terminal CCA addition
N7761_07355	COG4991	sh3 domain protein
N7761_07360	COG0306	phosphate transporter
N7761_07365	COG1392	Phosphate transport regulator
N7761_07370	COG3025	triphosphatase activity
N7761_07375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N7761_07380	COG1522	sequence-specific DNA binding
N7761_07395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N7761_07400	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N7761_07415	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N7761_07420	COG1177	transmembrane transport
N7761_07425	COG1176	ABC-type spermidine putrescine transport system, permease component I
N7761_07430	COG3842	ATPase activity
N7761_07440	COG3008	intermembrane lipid transfer
N7761_07445	COG2995	paraquat-inducible protein a
N7761_07455	COG0793	Belongs to the peptidase S41A family
N7761_07460	COG2989	Protein conserved in bacteria
N7761_07465	COG3108	Peptidase M15
N7761_07470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N7761_07475	COG0567	Dehydrogenase, E1 component
N7761_07480	COG0508	dehydrogenase complex catalyzes the overall conversion of
N7761_07490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N7761_07500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N7761_07510	COG3260	NADH ubiquinone oxidoreductase 20
N7761_07515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N7761_07520	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
N7761_07520	COG3261	NADH dehydrogenase
N7761_07525	COG0651	ATP synthesis coupled electron transport
N7761_07530	COG4237	Hydrogenase 4 membrane
N7761_07535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N7761_07540	COG0650	Formate hydrogenlyase subunit 4
N7761_07545	COG0651	ATP synthesis coupled electron transport
N7761_07550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N7761_07555	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N7761_07560	COG2864	formate dehydrogenase
N7761_07565	COG0437	4 iron, 4 sulfur cluster binding
N7761_07580	COG1609	Transcriptional regulator
N7761_07585	COG3265	gluconokinase activity
N7761_07590	COG2610	gluconate transmembrane transporter activity
N7761_07595	COG0210	DNA helicase
N7761_07600	COG1793	dna ligase
N7761_07605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N7761_07610	COG4115	mRNA cleavage
N7761_07615	COG2161	toxin-antitoxin pair type II binding
N7761_07620	COG5039	Polysaccharide pyruvyl transferase
N7761_07630	COG3306	glycosyltransferase involved in LPS biosynthesis
N7761_07640	COG1216	Glycosyl transferase, family 2
N7761_07645	COG1216	Glycosyl transferase, family 2
N7761_07650	COG2951	lytic endotransglycosylase activity
N7761_07685	COG0463	Glycosyl transferase, family 2
N7761_07705	COG2246	polysaccharide biosynthetic process
N7761_07710	COG1216	Glycosyl transferase, family 2
N7761_07735	COG0708	Exodeoxyribonuclease III
N7761_07740	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
N7761_07760	COG0671	phosphoesterase, PA-phosphatase related
N7761_07765	COG1940	carbohydrate kinase activity
N7761_07780	COG0515	serine threonine protein kinase
N7761_07790	COG1946	Acyl-CoA thioesterase
N7761_07800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N7761_07805	COG4988	ABC transporter
N7761_07810	COG0492	ferredoxin-NADP+ reductase activity
N7761_07815	COG3118	belongs to the thioredoxin family
N7761_07820	COG0676	glucose-6-phosphate 1-epimerase activity
N7761_07825	COG1199	ATP-dependent helicase activity
N7761_07830	COG1214	PFAM Peptidase M22, glycoprotease
N7761_07835	COG3065	identical protein binding
N7761_07840	COG0318	PFAM AMP-dependent synthetase and ligase
N7761_07845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N7761_07850	COG1858	cytochrome C peroxidase
N7761_07875	COG0330	HflC and HflK could
N7761_07885	COG2249	NAD(P)H dehydrogenase (quinone) activity
N7761_07890	COG3381	protein complex oligomerization
N7761_07895	COG1560	Kdo2-lipid A biosynthetic process
N7761_07900	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N7761_07900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N7761_07905	COG2166	iron-sulfur cluster assembly
N7761_07910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N7761_07915	COG1525	nuclease
N7761_07930	COG1346	cytolysis
N7761_07940	COG0488	(ABC) transporter
N7761_07960	COG3959	Transketolase, thiamine diphosphate binding domain
N7761_07965	COG3958	Transketolase
N7761_07980	COG1289	transmembrane transporter activity
N7761_07985	COG3304	Inner membrane component domain
N7761_08005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N7761_08010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N7761_08015	COG1121	(ABC) transporter
N7761_08025	COG2920	part of a sulfur-relay system
N7761_08035	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N7761_08065	COG0583	DNA-binding transcription factor activity
N7761_08070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N7761_08075	COG1687	branched-chain amino acid
N7761_08080	COG0612	Peptidase, M16
N7761_08085	COG4771	TonB-dependent receptor
N7761_08090	COG2990	Protein conserved in bacteria
N7761_08100	COG0539	negative regulation of cytoplasmic translation
N7761_08105	COG0776	regulation of translation
N7761_08110	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N7761_08115	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N7761_08125	COG0023	Translation Initiation Factor
N7761_08130	COG3094	Invasion gene expression up-regulator, SirB
N7761_08135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N7761_08140	COG0735	belongs to the Fur family
N7761_08145	COG0716	FMN binding
N7761_08155	COG0596	Alpha beta hydrolase
N7761_08160	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N7761_08165	COG0318	PFAM AMP-dependent synthetase and ligase
N7761_08170	COG3264	Mechanosensitive ion channel
N7761_08170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N7761_08175	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N7761_08180	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
N7761_08185	COG0730	response to heat
N7761_08190	COG1560	Kdo2-lipid A biosynthetic process
N7761_08200	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N7761_08205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N7761_08215	COG0463	Glycosyl transferase, family 2
N7761_08225	COG0251	oxidation-reduction process
N7761_08235	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N7761_08240	COG0625	glutathione transferase activity
N7761_08245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N7761_08250	COG0187	DNA topoisomerase II activity
N7761_08260	COG0488	(ABC) transporter
N7761_08265	COG3683	transport system, periplasmic component
N7761_08270	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N7761_08295	COG1263	PTS System
N7761_08295	COG2190	(PTS) system
N7761_08295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N7761_08300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
N7761_08310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N7761_08315	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N7761_08325	COG1737	Transcriptional regulator
N7761_08330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7761_08335	COG0363	glucosamine-6-phosphate deaminase activity
N7761_08340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N7761_08345	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N7761_08360	COG0277	FAD linked oxidase domain protein
N7761_08360	COG0247	lactate metabolic process
N7761_08380	COG2363	Small membrane protein
N7761_08385	COG1643	Atp-dependent helicase
N7761_08400	COG3385	transposase activity
N7761_08405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N7761_08415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N7761_08420	COG0577	efflux transmembrane transporter activity
N7761_08420	COG1136	(ABC) transporter
N7761_08430	COG0577	efflux transmembrane transporter activity
N7761_08445	COG0672	)-iron permease
N7761_08450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N7761_08460	COG0316	Belongs to the HesB IscA family
N7761_08465	COG0024	Methionine aminopeptidase
N7761_08475	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N7761_08480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N7761_08540	COG2801	Transposase and inactivated derivatives
N7761_08545	COG0193	aminoacyl-tRNA hydrolase activity
N7761_08550	COG0012	GTP binding
N7761_08555	COG1573	uracil-dna glycosylase
N7761_08560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N7761_08570	COG3115	cell septum assembly
N7761_08590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N7761_08595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N7761_08610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N7761_08620	COG0659	secondary active sulfate transmembrane transporter activity
N7761_08640	COG2186	Transcriptional regulator
N7761_08655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N7761_08665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N7761_08670	COG1028	Short-chain dehydrogenase reductase Sdr
N7761_08680	COG0800	Aldolase
N7761_08685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N7761_08690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N7761_08695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N7761_08700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N7761_08710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N7761_08715	COG1555	photosystem II stabilization
N7761_08720	COG0330	HflC and HflK could
N7761_08725	COG0330	HflC and HflK could
N7761_08730	COG2091	lysine biosynthetic process via aminoadipic acid
N7761_08735	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N7761_08750	COG0527	aspartate kinase activity
N7761_08750	COG0460	homoserine dehydrogenase
N7761_08760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N7761_08765	COG1125	glycine betaine transport
N7761_08765	COG0517	IMP dehydrogenase activity
N7761_08780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N7761_08785	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N7761_08795	COG1217	gtp-binding protein TYPA
N7761_08805	COG2801	Transposase and inactivated derivatives
N7761_08815	COG0861	Integral membrane protein TerC family
N7761_08825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N7761_08830	COG2067	long-chain fatty acid transport protein
N7761_08835	COG3691	Protein conserved in bacteria
N7761_08845	COG0463	Glycosyl transferase, family 2
N7761_08865	COG5007	Belongs to the BolA IbaG family
N7761_08870	COG3113	response to antibiotic
N7761_08875	COG2854	intermembrane phospholipid transfer
N7761_08880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N7761_08885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N7761_08890	COG1127	ABC transporter
N7761_08895	COG3117	lipopolysaccharide transmembrane transporter activity
N7761_08900	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N7761_08905	COG1137	ATPase activity
N7761_08910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_08925	COG2850	peptidyl-arginine hydroxylation
N7761_08945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N7761_08955	COG1758	RNA polymerase activity
N7761_08960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N7761_08970	COG3161	chorismate lyase activity
N7761_09010	COG1757	Na H antiporter
N7761_09015	COG2916	Histone family protein nucleoid-structuring protein H-NS
N7761_09020	COG0788	formyltetrahydrofolate deformylase activity
N7761_09030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N7761_09035	COG3101	peptidyl-lysine hydroxylation
N7761_09040	COG3842	ATPase activity
N7761_09045	COG1178	ABC-type Fe3 transport system permease component
N7761_09070	COG0745	RESPONSE REGULATOR receiver
N7761_09080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N7761_09080	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N7761_09085	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N7761_09090	COG3098	single-species biofilm formation
N7761_09100	COG3140	Belongs to the UPF0181 family
N7761_09105	COG1278	Cold shock
N7761_09115	COG1067	ATP-dependent peptidase activity
N7761_09120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N7761_09130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N7761_09135	COG1074	ATP-dependent DNA helicase activity
N7761_09140	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N7761_09160	COG0101	tRNA pseudouridine synthase activity
N7761_09175	COG0471	metal ion transport
N7761_09180	COG2315	Protein conserved in bacteria
N7761_09185	COG0243	molybdopterin cofactor binding
N7761_09190	COG3005	denitrification pathway
N7761_09215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N7761_09225	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N7761_09230	COG0314	molybdopterin synthase activity
N7761_09240	COG2969	positive regulation of protein catabolic process
N7761_09250	COG1940	carbohydrate kinase activity
N7761_09255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N7761_09265	COG2390	Transcriptional regulator
N7761_09275	COG1172	Belongs to the binding-protein-dependent transport system permease family
N7761_09285	COG1879	ABC-type sugar transport system periplasmic component
N7761_09300	COG0469	pyruvate kinase activity
N7761_09310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N7761_09320	COG0133	tryptophan synthase activity
N7761_09325	COG4221	oxidoreductase activity
N7761_09345	COG3630	sodium ion export across plasma membrane
N7761_09360	COG0298	carbon dioxide binding
N7761_09365	COG0135	phosphoribosylanthranilate isomerase activity
N7761_09365	COG0134	indole-3-glycerol-phosphate synthase activity
N7761_09370	COG3093	addiction module antidote protein HigA
N7761_09380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N7761_09385	COG1942	4-Oxalocrotonate Tautomerase
N7761_09390	COG0512	Glutamine amidotransferase of anthranilate synthase
N7761_09395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N7761_09400	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N7761_09405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N7761_09405	COG0517	IMP dehydrogenase activity
N7761_09420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N7761_09435	COG0791	NLP P60 protein
N7761_09460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7761_09465	COG1120	ATPase activity
N7761_09480	COG3585	molybdate ion transport
N7761_09485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N7761_09490	COG1120	ATPase activity
N7761_09495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N7761_09505	COG0842	Transport permease protein
N7761_09510	COG1129	ABC transporter
N7761_09510	COG0842	Transport permease protein
N7761_09515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7761_09530	COG1448	Aminotransferase
N7761_09535	COG0308	aminopeptidase N
N7761_09540	COG0167	dihydroorotate dehydrogenase activity
N7761_09555	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
N7761_09560	COG0589	response to stress
N7761_09565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N7761_09575	COG1528	Iron-storage protein
N7761_09580	COG1528	Iron-storage protein
N7761_09595	COG2801	Transposase and inactivated derivatives
N7761_09605	COG2925	Exonuclease
N7761_09610	COG0697	spore germination
N7761_09615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N7761_09620	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N7761_09625	COG0204	Acyl-transferase
N7761_09625	COG0318	PFAM AMP-dependent synthetase and ligase
N7761_09630	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
N7761_09635	COG1686	Belongs to the peptidase S11 family
N7761_09645	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N7761_09650	COG0586	Pfam SNARE associated Golgi protein
N7761_09655	COG0058	SHG alpha-glucan phosphorylase activity
N7761_09670	COG1523	belongs to the glycosyl hydrolase 13 family
N7761_09695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N7761_09700	COG0577	efflux transmembrane transporter activity
N7761_09700	COG1136	(ABC) transporter
N7761_09705	COG1538	Outer membrane efflux protein
N7761_09730	COG2824	Alkylphosphonate utilization operon protein PhnA
N7761_09740	COG0564	pseudouridine synthase activity
N7761_09745	COG2431	L-lysine efflux transmembrane transporter activity
N7761_09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N7761_09755	COG0406	alpha-ribazole phosphatase activity
N7761_09760	COG0285	dihydrofolate synthase activity
N7761_09775	COG0142	geranyltranstransferase activity
N7761_09785	COG1349	DNA-binding transcription factor activity
N7761_09790	COG1063	alcohol dehydrogenase
N7761_09795	COG3775	system Galactitol-specific IIC component
N7761_09800	COG3414	Phosphotransferase system galactitol-specific IIB component
N7761_09805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N7761_09815	COG3684	Belongs to the aldolase LacD family
N7761_09830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N7761_09835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N7761_09875	COG2885	chlorophyll binding
N7761_09875	COG3047	cAMP biosynthetic process
N7761_09880	COG0616	signal peptide processing
N7761_09890	COG1252	NADH dehydrogenase
N7761_09900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N7761_09910	COG0792	nuclease activity
N7761_09915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N7761_09920	COG2823	Periplasmic or secreted lipoprotein
N7761_09925	COG0288	reversible hydration of carbon dioxide
N7761_09930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N7761_09930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N7761_09935	COG0785	Cytochrome C biogenesis protein
N7761_09940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N7761_09960	COG2949	membrane
N7761_09965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N7761_09975	COG3099	Belongs to the UPF0263 family
N7761_09985	COG0583	DNA-binding transcription factor activity
N7761_09995	COG0009	L-threonylcarbamoyladenylate synthase
N7761_10005	COG0616	signal peptide processing
N7761_10010	COG0778	Nitroreductase
N7761_10015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N7761_10020	COG0508	dehydrogenase complex catalyzes the overall conversion of
N7761_10025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N7761_10035	COG2909	trisaccharide binding
N7761_10040	COG0058	SHG alpha-glucan phosphorylase activity
N7761_10045	COG1640	4-alpha-glucanotransferase
N7761_10050	COG1286	toxin biosynthetic process
N7761_10055	COG3092	negative regulation of chromosome organization
N7761_10060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N7761_10065	COG0280	phosphate acetyltransferase
N7761_10065	COG0857	belongs to the CobB CobQ family
N7761_10080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N7761_10085	COG0617	tRNA 3'-terminal CCA addition
N7761_10090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N7761_10095	COG0658	competence protein
N7761_10095	COG2333	competence protein COMEC
N7761_10100	COG1132	(ABC) transporter
N7761_10105	COG1663	tetraacyldisaccharide 4'-kinase activity
N7761_10110	COG2835	tetraacyldisaccharide 4'-kinase activity
N7761_10120	COG0322	excinuclease ABC activity
N7761_10130	COG0395	ABC-type sugar transport system, permease component
N7761_10135	COG1175	transmembrane transport
N7761_10150	COG3177	Filamentation induced by cAMP protein fic
N7761_10160	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N7761_10165	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N7761_10190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N7761_10215	COG0195	Participates in both transcription termination and antitermination
N7761_10230	COG3069	C4-dicarboxylate transmembrane transporter activity
N7761_10235	COG3077	Addiction module antitoxin, RelB DinJ family
N7761_10240	COG3041	Addiction module toxin RelE StbE family
N7761_10250	COG0582	viral genome integration into host DNA
N7761_10260	COG5301	cellulose 1,4-beta-cellobiosidase activity
N7761_10270	COG1598	PFAM Uncharacterised protein family UPF0150
N7761_10340	COG2351	hydroxyisourate hydrolase activity
N7761_10345	COG0825	malonyl-CoA metabolic process
N7761_10360	COG2252	PERMEase
N7761_10365	COG3152	Membrane
N7761_10370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N7761_10375	COG0375	protein maturation
N7761_10380	COG2814	Major facilitator Superfamily
N7761_10385	COG0563	adenylate kinase activity
N7761_10410	COG1846	Transcriptional regulator
N7761_10410	COG1940	carbohydrate kinase activity
N7761_10420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N7761_10435	COG3422	double-strand break repair
N7761_10445	COG1944	ATP diphosphatase activity
N7761_10450	COG3105	Protein conserved in bacteria
N7761_10455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N7761_10465	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N7761_10470	COG1178	ABC-type Fe3 transport system permease component
N7761_10475	COG4143	(ABC) transporter
N7761_10480	COG0351	phosphomethylpyrimidine kinase
N7761_10490	COG1518	maintenance of DNA repeat elements
N7761_10495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP