locus-tag	class	description
AANUM_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AANUM_0002	COG0592	DNA-directed DNA polymerase activity
AANUM_0004	COG2226	methyltransferase
AANUM_0007	COG2081	HI0933 family
AANUM_0008	COG4235	cytochrome complex assembly
AANUM_0008	COG3088	subunit of a heme lyase
AANUM_0009	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_0010	COG1138	Cytochrome C-type biogenesis protein
AANUM_0011	COG3301	Polysulphide reductase, NrfD
AANUM_0012	COG0437	4 iron, 4 sulfur cluster binding
AANUM_0013	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AANUM_0020	COG1138	Cytochrome C-type biogenesis protein
AANUM_0022	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_0023	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_0024	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_0025	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AANUM_0026	COG4133	protoheme IX ABC transporter activity
AANUM_0027	COG2814	Major facilitator Superfamily
AANUM_0036	COG2801	Transposase and inactivated derivatives
AANUM_0039	COG2267	carboxylic ester hydrolase activity
AANUM_0040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AANUM_0042	COG0436	Aminotransferase
AANUM_0045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AANUM_0046	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AANUM_0047	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AANUM_0049	COG1652	LysM domain
AANUM_0050	COG2321	neutral zinc metallopeptidase
AANUM_0053	COG0281	malic enzyme
AANUM_0053	COG0280	phosphate acetyltransferase
AANUM_0061	COG3091	SprT-like family
AANUM_0062	COG0814	amino acid
AANUM_0063	COG1760	l-serine dehydratase
AANUM_0064	COG0252	asparaginase activity
AANUM_0066	COG3063	Type IV pilus biogenesis stability protein PilW
AANUM_0067	COG1426	Protein conserved in bacteria
AANUM_0070	COG2976	Protein conserved in bacteria
AANUM_0072	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AANUM_0073	COG2233	PERMEase
AANUM_0074	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AANUM_0075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AANUM_0076	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AANUM_0077	COG0659	secondary active sulfate transmembrane transporter activity
AANUM_0082	COG2186	Transcriptional regulator
AANUM_0086	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AANUM_0088	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_0089	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_0092	COG0800	Aldolase
AANUM_0094	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AANUM_0095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AANUM_0096	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AANUM_0098	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AANUM_0099	COG1555	photosystem II stabilization
AANUM_0101	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AANUM_0104	COG0196	riboflavin kinase activity
AANUM_0105	COG0728	peptidoglycan biosynthetic process
AANUM_0108	COG0560	Phosphoserine phosphatase
AANUM_0110	COG0193	aminoacyl-tRNA hydrolase activity
AANUM_0111	COG0012	GTP binding
AANUM_0112	COG1573	uracil-dna glycosylase
AANUM_0113	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AANUM_0115	COG3115	cell septum assembly
AANUM_0119	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AANUM_0120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AANUM_0122	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AANUM_0123	COG0582	viral genome integration into host DNA
AANUM_0128	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AANUM_0129	COG0255	Belongs to the universal ribosomal protein uL29 family
AANUM_0130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AANUM_0131	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AANUM_0132	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AANUM_0133	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AANUM_0134	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AANUM_0135	COG0089	rRNA binding
AANUM_0137	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AANUM_0138	COG0051	transcription antitermination factor activity, RNA binding
AANUM_0139	COG0583	DNA-binding transcription factor activity
AANUM_0140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AANUM_0141	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AANUM_0142	COG2031	fatty acid transporter
AANUM_0143	COG0183	Belongs to the thiolase family
AANUM_0145	COG1288	antiporter activity
AANUM_0146	COG0549	Belongs to the carbamate kinase family
AANUM_0147	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AANUM_0148	COG0038	chloride channel
AANUM_0149	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AANUM_0151	COG1522	sequence-specific DNA binding
AANUM_0152	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AANUM_0154	COG1393	Belongs to the ArsC family
AANUM_0156	COG3036	rescue of stalled ribosome
AANUM_0157	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AANUM_0158	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AANUM_0161	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AANUM_0163	COG0569	domain protein
AANUM_0164	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AANUM_0164	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AANUM_0168	COG3161	chorismate lyase activity
AANUM_0170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AANUM_0171	COG1758	RNA polymerase activity
AANUM_0173	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AANUM_0176	COG2801	Transposase and inactivated derivatives
AANUM_0178	COG3293	Transposase
AANUM_0181	COG2271	Major facilitator Superfamily
AANUM_0183	COG1215	transferase activity, transferring glycosyl groups
AANUM_0184	COG1649	PFAM Uncharacterised BCR, COG1649
AANUM_0184	COG0726	polysaccharide deacetylase
AANUM_0185	COG0726	polysaccharide deacetylase
AANUM_0185	COG1649	PFAM Uncharacterised BCR, COG1649
AANUM_0188	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AANUM_0189	COG0561	phosphatase activity
AANUM_0190	COG3716	PTS system mannose fructose sorbose family IID component
AANUM_0191	COG3715	PTS system
AANUM_0192	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_0192	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_0193	COG0742	ribosomal rna small subunit methyltransferase
AANUM_0194	COG0552	protein localization to endoplasmic reticulum
AANUM_0195	COG2884	Cell division ATP-binding protein ftsE
AANUM_0196	COG2177	Part of the ABC transporter FtsEX involved in
AANUM_0213	COG0459	protein refolding
AANUM_0214	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AANUM_0216	COG1027	Aspartate ammonia-lyase
AANUM_0217	COG0859	PFAM glycosyl transferase family 9
AANUM_0219	COG3716	PTS system mannose fructose sorbose family IID component
AANUM_0220	COG3715	PTS system
AANUM_0221	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_0221	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_0222	COG2814	Major facilitator Superfamily
AANUM_0223	COG1609	Transcriptional regulator
AANUM_0223	COG2207	Transcriptional regulator
AANUM_0224	COG1757	Na H antiporter
AANUM_0225	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AANUM_0227	COG4214	carbohydrate transport
AANUM_0228	COG4214	carbohydrate transport
AANUM_0229	COG1129	ABC transporter
AANUM_0230	COG4213	ABC transporter substrate-binding protein
AANUM_0231	COG2115	Belongs to the xylose isomerase family
AANUM_0232	COG1070	Carbohydrate kinase
AANUM_0235	COG3070	regulator of competence-specific genes
AANUM_0236	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AANUM_0238	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AANUM_0239	COG3850	Histidine kinase
AANUM_0240	COG3062	negative regulation of establishment of protein localization
AANUM_0241	COG0243	molybdopterin cofactor binding
AANUM_0242	COG0437	4 iron, 4 sulfur cluster binding
AANUM_0243	COG0348	domain, Protein
AANUM_0244	COG3043	anaerobic respiration
AANUM_0245	COG3005	denitrification pathway
AANUM_0246	COG0754	glutathionylspermidine amidase activity
AANUM_0247	COG0859	PFAM glycosyl transferase family 9
AANUM_0249	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AANUM_0251	COG0737	Belongs to the 5'-nucleotidase family
AANUM_0257	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_0258	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_0260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_0271	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AANUM_0276	COG1011	Hydrolase
AANUM_0278	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AANUM_0282	COG1596	polysaccharide export
AANUM_0282	COG1555	photosystem II stabilization
AANUM_0283	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AANUM_0284	COG0561	phosphatase activity
AANUM_0285	COG1040	competence protein
AANUM_0288	COG1114	Component of the transport system for branched-chain amino acids
AANUM_0293	COG4804	nuclease activity
AANUM_0295	COG4545	Glutaredoxin-related protein
AANUM_0298	COG3381	protein complex oligomerization
AANUM_0299	COG3302	dmso reductase anchor subunit
AANUM_0300	COG0437	4 iron, 4 sulfur cluster binding
AANUM_0301	COG0437	4 iron, 4 sulfur cluster binding
AANUM_0302	COG0243	molybdopterin cofactor binding
AANUM_0303	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AANUM_0303	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AANUM_0304	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AANUM_0304	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AANUM_0306	COG5645	(Lipo)protein
AANUM_0307	COG0210	DNA helicase
AANUM_0309	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AANUM_0310	COG0110	maltose O-acetyltransferase activity
AANUM_0311	COG1238	metal cluster binding
AANUM_0322	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AANUM_0323	COG3610	response to peptide
AANUM_0324	COG2966	Psort location CytoplasmicMembrane, score
AANUM_0327	COG0545	Peptidyl-prolyl cis-trans isomerase
AANUM_0328	COG0688	phosphatidylethanolamine metabolic process
AANUM_0329	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AANUM_0331	COG2830	Protein of unknown function (DUF452)
AANUM_0332	COG0500	methyltransferase
AANUM_0334	COG1399	metal-binding, possibly nucleic acid-binding protein
AANUM_0335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AANUM_0336	COG0416	fatty acid biosynthetic process
AANUM_0338	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AANUM_0339	COG1028	Short-chain dehydrogenase reductase Sdr
AANUM_0341	COG2814	Major facilitator Superfamily
AANUM_0342	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AANUM_0343	COG0513	Belongs to the DEAD box helicase family
AANUM_0344	COG0799	negative regulation of ribosome biogenesis
AANUM_0346	COG0768	penicillin binding
AANUM_0347	COG0772	Belongs to the SEDS family
AANUM_0348	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_0348	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_0349	COG1686	Belongs to the peptidase S11 family
AANUM_0356	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AANUM_0357	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AANUM_0358	COG0765	amino acid transport
AANUM_0359	COG1126	abc transporter atp-binding protein
AANUM_0360	COG2168	tRNA wobble position uridine thiolation
AANUM_0362	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AANUM_0363	COG2964	Protein conserved in bacteria
AANUM_0364	COG0545	Peptidyl-prolyl cis-trans isomerase
AANUM_0366	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AANUM_0366	COG0678	peroxiredoxin activity
AANUM_0367	COG0583	DNA-binding transcription factor activity
AANUM_0368	COG1309	transcriptional regulator
AANUM_0369	COG1132	(ABC) transporter
AANUM_0370	COG4988	ABC transporter
AANUM_0371	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AANUM_0372	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AANUM_0373	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AANUM_0375	COG1045	serine acetyltransferase
AANUM_0376	COG1494	fructose-1,6-bisphosphatase
AANUM_0378	COG0716	FMN binding
AANUM_0380	COG0702	epimerase
AANUM_0382	COG1733	regulation of RNA biosynthetic process
AANUM_0384	COG3312	ion transport
AANUM_0388	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AANUM_0390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AANUM_0393	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AANUM_0394	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AANUM_0396	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AANUM_0398	COG1349	DNA-binding transcription factor activity
AANUM_0405	COG3501	Rhs element vgr protein
AANUM_0420	COG1720	tRNA m6t6A37 methyltransferase activity
AANUM_0421	COG1575	Belongs to the MenA family. Type 1 subfamily
AANUM_0423	COG0471	metal ion transport
AANUM_0424	COG3028	Belongs to the UPF0307 family
AANUM_0425	COG0312	modulator of DNA gyrase
AANUM_0426	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AANUM_0427	COG1929	Belongs to the glycerate kinase type-1 family
AANUM_0428	COG2610	gluconate transmembrane transporter activity
AANUM_0429	COG3835	regulator
AANUM_0431	COG0513	Belongs to the DEAD box helicase family
AANUM_0432	COG4785	May be involved in cell division
AANUM_0434	COG2731	YhcH YjgK YiaL family protein
AANUM_0435	COG3023	N-Acetylmuramoyl-L-alanine amidase
AANUM_0436	COG4969	Belongs to the N-Me-Phe pilin family
AANUM_0437	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AANUM_0438	COG1459	type II secretion system
AANUM_0445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AANUM_0446	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AANUM_0447	COG0805	protein transport
AANUM_0450	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AANUM_0452	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AANUM_0454	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AANUM_0456	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AANUM_0458	COG1841	ribosomal large subunit assembly
AANUM_0460	COG0201	protein transport
AANUM_0463	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AANUM_0466	COG0814	amino acid
AANUM_0467	COG2129	metallophosphoesterase
AANUM_0468	COG3172	ATPase kinase involved in NAD metabolism
AANUM_0469	COG2960	long-chain fatty acid transporting porin activity
AANUM_0473	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AANUM_0474	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
AANUM_0481	COG0513	Belongs to the DEAD box helicase family
AANUM_0483	COG3201	nicotinamide mononucleotide transporter
AANUM_0485	COG3501	Rhs element vgr protein
AANUM_0486	COG3078	GTPase activator activity
AANUM_0488	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AANUM_0489	COG0456	acetyltransferase
AANUM_0491	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AANUM_0496	COG0511	ligase activity, forming carbon-carbon bonds
AANUM_0497	COG0439	Biotin carboxylase
AANUM_0500	COG3924	membrane
AANUM_0501	COG4145	pantothenate transmembrane transporter activity
AANUM_0502	COG2184	nucleotidyltransferase activity
AANUM_0507	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AANUM_0508	COG1115	amino acid carrier protein
AANUM_0510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AANUM_0511	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AANUM_0511	COG0237	dephospho-CoA kinase activity
AANUM_0516	COG2918	glutathione biosynthetic process
AANUM_0516	COG1181	Belongs to the D-alanine--D-alanine ligase family
AANUM_0517	COG2194	sulfuric ester hydrolase activity
AANUM_0518	COG0740	serine-type endopeptidase activity
AANUM_0522	COG3739	integral membrane protein
AANUM_0523	COG2217	Heavy metal translocating P-type atpase
AANUM_0524	COG2608	mercury ion transmembrane transporter activity
AANUM_0525	COG0789	Transcriptional regulator
AANUM_0528	COG3676	manually curated
AANUM_0529	COG2932	Transcriptional regulator
AANUM_0533	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AANUM_0537	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AANUM_0546	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AANUM_0547	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AANUM_0548	COG1011	Hydrolase
AANUM_0549	COG0494	nUDIX hydrolase
AANUM_0550	COG4977	sequence-specific DNA binding
AANUM_0550	COG1917	Cupin 2, conserved barrel domain protein
AANUM_0551	COG3059	membrane
AANUM_0552	COG1297	OPT oligopeptide transporter protein
AANUM_0554	COG1218	3'(2'),5'-bisphosphate nucleotidase
AANUM_0555	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AANUM_0556	COG0363	glucosamine-6-phosphate deaminase activity
AANUM_0560	COG0762	integral membrane protein
AANUM_0562	COG0778	Nitroreductase
AANUM_0563	COG1368	sulfuric ester hydrolase activity
AANUM_0564	COG1368	sulfuric ester hydrolase activity
AANUM_0571	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AANUM_0574	COG0006	proline dipeptidase activity
AANUM_0579	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AANUM_0580	COG1792	Involved in formation and maintenance of cell shape
AANUM_0581	COG1077	Cell shape determining protein MreB Mrl
AANUM_0582	COG0557	exoribonuclease II activity
AANUM_0584	COG2271	Major facilitator Superfamily
AANUM_0585	COG0584	glycerophosphoryl diester phosphodiesterase
AANUM_0586	COG0758	DNA mediated transformation
AANUM_0593	COG1132	(ABC) transporter
AANUM_0594	COG4977	sequence-specific DNA binding
AANUM_0594	COG1917	Cupin 2, conserved barrel domain protein
AANUM_0595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AANUM_0596	COG0859	PFAM glycosyl transferase family 9
AANUM_0599	COG1519	Transferase
AANUM_0600	COG0463	Glycosyl transferase, family 2
AANUM_0603	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AANUM_0604	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AANUM_0605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AANUM_0606	COG3719	Belongs to the RNase T2 family
AANUM_0608	COG0191	fructose-bisphosphate aldolase activity
AANUM_0609	COG3307	-O-antigen
AANUM_0610	COG2267	carboxylic ester hydrolase activity
AANUM_0611	COG0561	phosphatase activity
AANUM_0614	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AANUM_0617	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AANUM_0619	COG0583	DNA-binding transcription factor activity
AANUM_0620	COG2962	Rard protein
AANUM_0623	COG0551	DNA topoisomerase type I activity
AANUM_0628	COG0705	Rhomboid family
AANUM_0629	COG1349	DNA-binding transcription factor activity
AANUM_0632	COG4178	(ABC) transporter
AANUM_0635	COG0233	cytoplasmic translational termination
AANUM_0638	COG0575	Belongs to the CDS family
AANUM_0641	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AANUM_0643	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AANUM_0647	COG0490	domain, Protein
AANUM_0647	COG0471	metal ion transport
AANUM_0648	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AANUM_0650	COG4589	Belongs to the CDS family
AANUM_0651	COG0521	Mo-molybdopterin cofactor biosynthetic process
AANUM_0665	COG3276	selenocysteine insertion sequence binding
AANUM_0666	COG1921	L-seryl-tRNASec selenium transferase activity
AANUM_0667	COG0442	prolyl-tRNA aminoacylation
AANUM_0670	COG1595	DNA-templated transcription, initiation
AANUM_0671	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
AANUM_0672	COG3026	antisigma factor binding
AANUM_0673	COG3086	response to oxidative stress
AANUM_0674	COG1763	Mo-molybdopterin cofactor biosynthetic process
AANUM_0675	COG0300	oxidoreductase activity
AANUM_0676	COG2195	Cleaves the N-terminal amino acid of tripeptides
AANUM_0678	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AANUM_0679	COG2818	Glycosylase
AANUM_0680	COG3477	response to acidic pH
AANUM_0681	COG0019	diaminopimelate decarboxylase activity
AANUM_0684	COG0514	ATP-dependent DNA helicase (RecQ)
AANUM_0685	COG0187	DNA topoisomerase II activity
AANUM_0686	COG1072	(Pantothenic acid kinase))
AANUM_0688	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AANUM_0689	COG1879	ABC-type sugar transport system periplasmic component
AANUM_0690	COG1129	ABC transporter
AANUM_0691	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_0693	COG2183	response to ionizing radiation
AANUM_0694	COG2183	response to ionizing radiation
AANUM_0696	COG2801	Transposase and inactivated derivatives
AANUM_0697	COG2801	Transposase and inactivated derivatives
AANUM_0698	COG0583	DNA-binding transcription factor activity
AANUM_0699	COG0471	metal ion transport
AANUM_0701	COG2183	response to ionizing radiation
AANUM_0702	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AANUM_0704	COG1595	DNA-templated transcription, initiation
AANUM_0706	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AANUM_0707	COG3071	HemY protein
AANUM_0708	COG2959	enzyme of heme biosynthesis
AANUM_0710	COG0181	hydroxymethylbilane synthase activity
AANUM_0712	COG2197	response regulator
AANUM_0713	COG0729	surface antigen
AANUM_0714	COG2911	Protein conserved in bacteria
AANUM_0715	COG0248	Ppx GppA phosphatase
AANUM_0719	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AANUM_0720	COG3068	Protein conserved in bacteria
AANUM_0722	COG1349	DNA-binding transcription factor activity
AANUM_0723	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AANUM_0727	COG2272	Belongs to the type-B carboxylesterase lipase family
AANUM_0728	COG0667	Aldo Keto reductase
AANUM_0729	COG0656	L-ascorbic acid biosynthetic process
AANUM_0732	COG0433	COG0433 Predicted ATPase
AANUM_0733	COG2258	MOSC domain
AANUM_0734	COG3012	SEC-C Motif Domain Protein
AANUM_0736	COG1490	D-aminoacyl-tRNA deacylase activity
AANUM_0737	COG0786	glutamate:sodium symporter activity
AANUM_0738	COG2205	protein histidine kinase activity
AANUM_0739	COG0745	RESPONSE REGULATOR receiver
AANUM_0740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AANUM_0742	COG3082	Protein of unknown function (DUF1414)
AANUM_0743	COG3083	sulfuric ester hydrolase activity
AANUM_0744	COG0402	S-adenosylhomocysteine deaminase activity
AANUM_0745	COG3956	TIGRFAM MazG family protein
AANUM_0748	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AANUM_0750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AANUM_0751	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AANUM_0752	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AANUM_0755	COG0148	phosphopyruvate hydratase activity
AANUM_0757	COG2991	Protein conserved in bacteria
AANUM_0758	COG1477	protein flavinylation
AANUM_0759	COG2871	sodium ion transport
AANUM_0760	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_0761	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_0762	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AANUM_0765	COG0271	Belongs to the BolA IbaG family
AANUM_0766	COG3056	Lipoprotein
AANUM_0768	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AANUM_0769	COG1194	a g-specific adenine glycosylase
AANUM_0771	COG3171	Protein conserved in bacteria
AANUM_0772	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_0773	COG1178	ABC-type Fe3 transport system permease component
AANUM_0774	COG3842	ATPase activity
AANUM_0777	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AANUM_0779	COG1561	YicC-like family, N-terminal region
AANUM_0780	COG0354	folic acid binding
AANUM_0784	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AANUM_0785	COG1381	Involved in DNA repair and RecF pathway recombination
AANUM_0786	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AANUM_0787	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AANUM_0788	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AANUM_0790	COG0500	methyltransferase
AANUM_0791	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AANUM_0792	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_0793	COG1309	transcriptional regulator
AANUM_0794	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AANUM_0795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AANUM_0798	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_0799	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_0801	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_0805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AANUM_0808	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AANUM_0810	COG1309	transcriptional regulator
AANUM_0812	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AANUM_0813	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AANUM_0814	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AANUM_0815	COG4972	Pilus assembly protein
AANUM_0819	COG4796	Type ii and iii secretion system protein
AANUM_0822	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AANUM_0827	COG0653	protein targeting
AANUM_0830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AANUM_0833	COG2801	Transposase and inactivated derivatives
AANUM_0834	COG0789	Transcriptional regulator
AANUM_0835	COG4701	Protein of unknown function (DUF721)
AANUM_0838	COG0494	nUDIX hydrolase
AANUM_0839	COG1466	dna polymerase III delta subunit
AANUM_0840	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AANUM_0843	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AANUM_0844	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
AANUM_0845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AANUM_0846	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AANUM_0847	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AANUM_0851	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AANUM_0853	COG4221	oxidoreductase activity
AANUM_0854	COG0789	Transcriptional regulator
AANUM_0855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AANUM_0856	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AANUM_0857	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AANUM_0859	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AANUM_0860	COG4137	Cytochrome C assembly protein
AANUM_0861	COG4536	flavin adenine dinucleotide binding
AANUM_0862	COG0811	peptide transport
AANUM_0863	COG0848	biopolymer transport protein
AANUM_0865	COG4783	chaperone-mediated protein folding
AANUM_0867	COG0814	amino acid
AANUM_0872	COG0747	negative chemotaxis
AANUM_0873	COG2853	Lipoprotein
AANUM_0876	COG3501	Rhs element vgr protein
AANUM_0888	COG3561	AntA/AntB antirepressor
AANUM_0897	COG0582	viral genome integration into host DNA
AANUM_0901	COG2095	MarC family integral membrane protein
AANUM_0903	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AANUM_0904	COG2137	regulation of response to DNA damage stimulus
AANUM_0905	COG0251	oxidation-reduction process
AANUM_0907	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AANUM_0908	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_0910	COG1285	pathogenesis
AANUM_0912	COG0733	neurotransmitter:sodium symporter activity
AANUM_0913	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AANUM_0916	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AANUM_0922	COG1238	metal cluster binding
AANUM_0924	COG1388	LysM domain
AANUM_0924	COG4942	peptidase
AANUM_0927	COG0105	UTP biosynthetic process
AANUM_0931	COG4535	Mg2 and Co2 transporter CorC
AANUM_0932	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
AANUM_0934	COG2301	Belongs to the HpcH HpaI aldolase family
AANUM_0935	COG3051	citrate lyase alpha subunit
AANUM_0936	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
AANUM_0936	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AANUM_0937	COG0471	metal ion transport
AANUM_0940	COG2017	converts alpha-aldose to the beta-anomer
AANUM_0942	COG1085	galactose-1-phosphate uridylyltransferase
AANUM_0943	COG1609	Transcriptional regulator
AANUM_0944	COG1879	ABC-type sugar transport system periplasmic component
AANUM_0947	COG4211	Belongs to the binding-protein-dependent transport system permease family
AANUM_0948	COG5002	protein histidine kinase activity
AANUM_0948	COG2198	Histidine kinase
AANUM_0948	COG0784	Response regulator, receiver
AANUM_0949	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AANUM_0950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AANUM_0950	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AANUM_0953	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AANUM_0954	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AANUM_0956	COG0497	DNA recombination
AANUM_0957	COG3047	cAMP biosynthetic process
AANUM_0958	COG2917	probably involved in intracellular septation
AANUM_0959	COG1607	acyl-coa hydrolase
AANUM_0960	COG2350	Protein conserved in bacteria
AANUM_0961	COG0741	lytic transglycosylase activity
AANUM_0963	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AANUM_0964	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AANUM_0967	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AANUM_0968	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AANUM_0969	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AANUM_0971	COG1408	metallophosphoesterase
AANUM_0972	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AANUM_0973	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_0974	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_0975	COG1120	ATPase activity
AANUM_0977	COG1053	succinate dehydrogenase
AANUM_0978	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AANUM_0980	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AANUM_0988	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AANUM_0989	COG0494	nUDIX hydrolase
AANUM_0990	COG1876	peptidase activity
AANUM_0992	COG1393	Belongs to the ArsC family
AANUM_0993	COG0326	Molecular chaperone. Has ATPase activity
AANUM_0994	COG0077	Prephenate dehydratase
AANUM_0994	COG1605	Chorismate mutase
AANUM_0996	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AANUM_0997	COG0849	cell division
AANUM_0998	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AANUM_1001	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AANUM_1005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AANUM_1007	COG0768	penicillin binding
AANUM_1008	COG3116	cell division
AANUM_1011	COG1966	Carbon starvation protein
AANUM_1012	COG4160	amino acid transport
AANUM_1013	COG4215	(ABC) transporter
AANUM_1014	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AANUM_1015	COG1126	abc transporter atp-binding protein
AANUM_1017	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AANUM_1019	COG1444	tRNA N-acetyltransferase activity
AANUM_1021	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AANUM_1025	COG4964	Belongs to the GSP D family
AANUM_1037	COG2801	Transposase and inactivated derivatives
AANUM_1039	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_1047	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AANUM_1047	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AANUM_1047	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AANUM_1048	COG1105	Belongs to the carbohydrate kinase PfkB family
AANUM_1049	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_1049	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_1051	COG0746	molybdenum cofactor guanylyltransferase activity
AANUM_1052	COG3084	Protein conserved in bacteria
AANUM_1053	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_1054	COG3085	chromosome segregation
AANUM_1063	COG0561	phosphatase activity
AANUM_1065	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AANUM_1067	COG2610	gluconate transmembrane transporter activity
AANUM_1068	COG3622	Belongs to the hyi family
AANUM_1069	COG0235	Class ii aldolase
AANUM_1070	COG3395	kinase activity
AANUM_1071	COG2084	Dehydrogenase
AANUM_1072	COG1349	DNA-binding transcription factor activity
AANUM_1073	COG0347	Belongs to the P(II) protein family
AANUM_1074	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AANUM_1075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AANUM_1076	COG0470	DNA polymerase III
AANUM_1077	COG0084	hydrolase, TatD family'
AANUM_1079	COG1253	flavin adenine dinucleotide binding
AANUM_1085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AANUM_1086	COG4942	peptidase
AANUM_1087	COG2861	carbohydrate metabolic process
AANUM_1088	COG0606	chelatase, subunit chli
AANUM_1090	COG2990	Protein conserved in bacteria
AANUM_1091	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AANUM_1096	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AANUM_1104	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AANUM_1107	COG0084	hydrolase, TatD family'
AANUM_1108	COG0602	queuosine metabolic process
AANUM_1109	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AANUM_1109	COG1328	CTP reductase activity
AANUM_1111	COG1022	Amp-dependent synthetase and ligase
AANUM_1112	COG0587	DNA-directed DNA polymerase activity
AANUM_1117	COG0753	catalase activity
AANUM_1118	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AANUM_1119	COG0165	Argininosuccinate lyase
AANUM_1122	COG0582	viral genome integration into host DNA
AANUM_1146	COG3561	AntA/AntB antirepressor
AANUM_1154	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AANUM_1163	COG3179	chitinase
AANUM_1166	COG3728	DNA packaging
AANUM_1168	COG3567	Phage-associated protein, HI1409 family
AANUM_1169	COG2369	cell adhesion
AANUM_1171	COG3566	protein conserved in bacteria
AANUM_1172	COG3566	protein conserved in bacteria
AANUM_1192	COG5301	cellulose 1,4-beta-cellobiosidase activity
AANUM_1195	COG1278	Cold shock
AANUM_1196	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_1197	COG1879	ABC-type sugar transport system periplasmic component
AANUM_1198	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_1200	COG1869	D-ribose catabolic process
AANUM_1202	COG0730	response to heat
AANUM_1204	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AANUM_1205	COG0590	tRNA wobble adenosine to inosine editing
AANUM_1212	COG3501	Rhs element vgr protein
AANUM_1214	COG0489	protein tyrosine kinase activity
AANUM_1215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AANUM_1215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AANUM_1216	COG2975	iron-sulfur cluster assembly
AANUM_1217	COG0633	Ferredoxin
AANUM_1218	COG0443	Heat shock 70 kDa protein
AANUM_1221	COG0822	iron-sulfur transferase activity
AANUM_1223	COG1959	2 iron, 2 sulfur cluster binding
AANUM_1224	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AANUM_1233	COG0626	cystathionine gamma-synthase activity
AANUM_1234	COG0626	cystathionine gamma-synthase activity
AANUM_1235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AANUM_1238	COG1530	ribonuclease E activity
AANUM_1239	COG2259	Doxx family
AANUM_1241	COG1611	Belongs to the LOG family
AANUM_1243	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AANUM_1244	COG0745	RESPONSE REGULATOR receiver
AANUM_1245	COG4608	Belongs to the ABC transporter superfamily
AANUM_1246	COG0444	Belongs to the ABC transporter superfamily
AANUM_1247	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AANUM_1248	COG0601	transmembrane transport
AANUM_1249	COG0601	transmembrane transport
AANUM_1250	COG0601	transmembrane transport
AANUM_1251	COG4166	transmembrane transport
AANUM_1253	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AANUM_1254	COG0697	spore germination
AANUM_1255	COG0697	spore germination
AANUM_1258	COG0142	geranyltranstransferase activity
AANUM_1259	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AANUM_1262	COG2056	Na+-H+ antiporter family
AANUM_1263	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AANUM_1264	COG0346	lactoylglutathione lyase activity
AANUM_1266	COG2271	Major facilitator Superfamily
AANUM_1269	COG1755	Isoprenylcysteine carboxyl methyltransferase
AANUM_1270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AANUM_1271	COG2801	Transposase and inactivated derivatives
AANUM_1275	COG0494	nUDIX hydrolase
AANUM_1276	COG0217	transcriptional regulatory protein
AANUM_1282	COG1271	oxidase subunit
AANUM_1283	COG1294	oxidase, subunit
AANUM_1284	COG0824	Thioesterase
AANUM_1285	COG0811	peptide transport
AANUM_1286	COG0848	biopolymer transport protein
AANUM_1287	COG3064	Membrane
AANUM_1290	COG2165	general secretion pathway protein
AANUM_1291	COG4795	General secretion pathway protein
AANUM_1294	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AANUM_1295	COG0456	acetyltransferase
AANUM_1296	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
AANUM_1297	COG2813	Specifically methylates the guanine in position
AANUM_1301	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AANUM_1303	COG2994	toxin metabolic process
AANUM_1304	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AANUM_1305	COG2274	protein secretion by the type I secretion system
AANUM_1306	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_1308	COG0246	Mannitol dehydrogenase
AANUM_1309	COG3722	fumarate hydratase activity
AANUM_1310	COG0673	inositol 2-dehydrogenase activity
AANUM_1312	COG3962	Belongs to the TPP enzyme family
AANUM_1313	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AANUM_1321	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AANUM_1326	COG3623	hexulose-6-phosphate isomerase
AANUM_1327	COG0235	Class ii aldolase
AANUM_1333	COG0814	amino acid
AANUM_1335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AANUM_1336	COG0778	Nitroreductase
AANUM_1338	COG2268	Band 7 protein
AANUM_1339	COG0114	fumarate hydratase activity
AANUM_1340	COG2927	DNA polymerase III (CHI subunit)
AANUM_1345	COG3550	peptidyl-serine autophosphorylation
AANUM_1347	COG2814	Major facilitator Superfamily
AANUM_1348	COG1566	PFAM secretion protein HlyD family protein
AANUM_1349	COG1566	PFAM secretion protein HlyD family protein
AANUM_1350	COG0783	Belongs to the Dps family
AANUM_1351	COG0783	Belongs to the Dps family
AANUM_1353	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AANUM_1354	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AANUM_1355	COG0602	queuosine metabolic process
AANUM_1356	COG0720	synthase
AANUM_1364	COG0673	inositol 2-dehydrogenase activity
AANUM_1366	COG1879	ABC-type sugar transport system periplasmic component
AANUM_1367	COG1129	ABC transporter
AANUM_1368	COG1129	ABC transporter
AANUM_1369	COG1172	Belongs to the binding-protein-dependent transport system permease family
AANUM_1370	COG1012	belongs to the aldehyde dehydrogenase family
AANUM_1370	COG1454	alcohol dehydrogenase
AANUM_1372	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AANUM_1373	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AANUM_1374	COG1862	Preprotein translocase
AANUM_1376	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AANUM_1389	COG2026	Addiction module toxin, RelE StbE family
AANUM_1391	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AANUM_1393	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AANUM_1397	COG1620	l-lactate permease
AANUM_1401	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AANUM_1402	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AANUM_1403	COG0617	tRNA 3'-terminal CCA addition
AANUM_1404	COG4991	sh3 domain protein
AANUM_1405	COG0306	phosphate transporter
AANUM_1406	COG1392	Phosphate transport regulator
AANUM_1407	COG3025	triphosphatase activity
AANUM_1408	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AANUM_1409	COG0563	adenylate kinase activity
AANUM_1410	COG2814	Major facilitator Superfamily
AANUM_1411	COG0375	protein maturation
AANUM_1412	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AANUM_1413	COG3152	Membrane
AANUM_1414	COG2252	PERMEase
AANUM_1417	COG0825	malonyl-CoA metabolic process
AANUM_1418	COG2351	hydroxyisourate hydrolase activity
AANUM_1421	COG3041	Addiction module toxin RelE StbE family
AANUM_1422	COG3077	Addiction module antitoxin, RelB DinJ family
AANUM_1423	COG3069	C4-dicarboxylate transmembrane transporter activity
AANUM_1425	COG2801	Transposase and inactivated derivatives
AANUM_1426	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_1427	COG0785	Cytochrome C biogenesis protein
AANUM_1428	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AANUM_1428	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AANUM_1429	COG0288	reversible hydration of carbon dioxide
AANUM_1430	COG2823	Periplasmic or secreted lipoprotein
AANUM_1431	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AANUM_1432	COG0792	nuclease activity
AANUM_1434	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AANUM_1436	COG1252	NADH dehydrogenase
AANUM_1437	COG1252	NADH dehydrogenase
AANUM_1439	COG0616	signal peptide processing
AANUM_1440	COG2885	chlorophyll binding
AANUM_1440	COG3047	cAMP biosynthetic process
AANUM_1441	COG0625	glutathione transferase activity
AANUM_1442	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AANUM_1443	COG0187	DNA topoisomerase II activity
AANUM_1445	COG0488	(ABC) transporter
AANUM_1446	COG3683	transport system, periplasmic component
AANUM_1447	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AANUM_1450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AANUM_1451	COG3105	Protein conserved in bacteria
AANUM_1452	COG1944	ATP diphosphatase activity
AANUM_1454	COG3422	double-strand break repair
AANUM_1456	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_1456	COG2190	(PTS) system
AANUM_1456	COG1263	PTS System
AANUM_1457	COG2226	methyltransferase
AANUM_1458	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AANUM_1460	COG1846	Transcriptional regulator
AANUM_1460	COG1940	carbohydrate kinase activity
AANUM_1470	COG3501	Rhs element vgr protein
AANUM_1473	COG1263	PTS System
AANUM_1473	COG2190	(PTS) system
AANUM_1473	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AANUM_1474	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
AANUM_1475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AANUM_1475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AANUM_1476	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AANUM_1477	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AANUM_1479	COG1737	Transcriptional regulator
AANUM_1480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AANUM_1481	COG0363	glucosamine-6-phosphate deaminase activity
AANUM_1482	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AANUM_1483	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AANUM_1486	COG0277	FAD linked oxidase domain protein
AANUM_1486	COG0247	lactate metabolic process
AANUM_1491	COG2363	Small membrane protein
AANUM_1492	COG1643	Atp-dependent helicase
AANUM_1493	COG1643	Atp-dependent helicase
AANUM_1495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AANUM_1497	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AANUM_1498	COG0577	efflux transmembrane transporter activity
AANUM_1498	COG1136	(ABC) transporter
AANUM_1500	COG0577	efflux transmembrane transporter activity
AANUM_1500	COG1136	(ABC) transporter
AANUM_1503	COG0672	)-iron permease
AANUM_1504	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AANUM_1505	COG0316	Belongs to the HesB IscA family
AANUM_1506	COG0024	Methionine aminopeptidase
AANUM_1508	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AANUM_1509	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AANUM_1510	COG4172	Belongs to the ABC transporter superfamily
AANUM_1511	COG4172	Belongs to the ABC transporter superfamily
AANUM_1512	COG4171	peptide transport system, permease
AANUM_1513	COG4168	peptide transport system, permease
AANUM_1514	COG4166	transmembrane transport
AANUM_1515	COG3106	COG3106 Predicted ATPase
AANUM_1517	COG3283	Transcriptional regulator of aromatic amino acids metabolism
AANUM_1518	COG1923	regulation of RNA biosynthetic process
AANUM_1521	COG0860	N-Acetylmuramoyl-L-alanine amidase
AANUM_1521	COG1388	LysM domain
AANUM_1522	COG0802	atpase or kinase
AANUM_1528	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AANUM_1530	COG2194	sulfuric ester hydrolase activity
AANUM_1537	COG2337	Toxic component of a toxin-antitoxin (TA) module
AANUM_1541	COG3021	interspecies interaction between organisms
AANUM_1555	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_1556	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AANUM_1557	COG2190	(PTS) system
AANUM_1558	COG0339	signal peptide processing
AANUM_1559	COG2832	Protein of unknown function (DUF454)
AANUM_1560	COG4166	transmembrane transport
AANUM_1561	COG4166	transmembrane transport
AANUM_1566	COG3501	Rhs element vgr protein
AANUM_1568	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AANUM_1570	COG0512	Glutamine amidotransferase of anthranilate synthase
AANUM_1571	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AANUM_1575	COG2801	Transposase and inactivated derivatives
AANUM_1576	COG2801	Transposase and inactivated derivatives
AANUM_1579	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AANUM_1581	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AANUM_1582	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AANUM_1583	COG3684	Belongs to the aldolase LacD family
AANUM_1584	COG3775	system Galactitol-specific IIC component
AANUM_1585	COG1063	alcohol dehydrogenase
AANUM_1586	COG1349	DNA-binding transcription factor activity
AANUM_1588	COG0142	geranyltranstransferase activity
AANUM_1591	COG0285	dihydrofolate synthase activity
AANUM_1592	COG0406	alpha-ribazole phosphatase activity
AANUM_1593	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AANUM_1594	COG2431	L-lysine efflux transmembrane transporter activity
AANUM_1595	COG0564	pseudouridine synthase activity
AANUM_1598	COG2824	Alkylphosphonate utilization operon protein PhnA
AANUM_1600	COG1538	Outer membrane efflux protein
AANUM_1601	COG0577	efflux transmembrane transporter activity
AANUM_1601	COG1136	(ABC) transporter
AANUM_1602	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_1606	COG2983	Belongs to the UPF0260 family
AANUM_1611	COG4591	ABC-type transport system involved in lipoprotein release permease component
AANUM_1613	COG4591	ABC-type transport system involved in lipoprotein release permease component
AANUM_1614	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AANUM_1615	COG0305	Participates in initiation and elongation during chromosome replication
AANUM_1617	COG0166	Belongs to the GPI family
AANUM_1619	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AANUM_1620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AANUM_1621	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AANUM_1622	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AANUM_1623	COG1280	lysine exporter protein (LysE YggA)
AANUM_1625	COG0633	Ferredoxin
AANUM_1627	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_1632	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_1634	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_1636	COG3842	ATPase activity
AANUM_1637	COG0366	Alpha amylase catalytic
AANUM_1638	COG3833	ABC-type maltose transport systems, permease component
AANUM_1640	COG2182	Extracellular solute-binding protein
AANUM_1641	COG3842	ATPase activity
AANUM_1642	COG4580	involved in the transport of maltose and maltodextrins
AANUM_1644	COG0676	glucose-6-phosphate 1-epimerase activity
AANUM_1645	COG1199	ATP-dependent helicase activity
AANUM_1646	COG1214	PFAM Peptidase M22, glycoprotease
AANUM_1647	COG3065	identical protein binding
AANUM_1648	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_1649	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_1650	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AANUM_1651	COG1858	cytochrome C peroxidase
AANUM_1656	COG0330	HflC and HflK could
AANUM_1658	COG2249	NAD(P)H dehydrogenase (quinone) activity
AANUM_1659	COG3381	protein complex oligomerization
AANUM_1660	COG1560	Kdo2-lipid A biosynthetic process
AANUM_1661	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AANUM_1661	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AANUM_1662	COG2166	iron-sulfur cluster assembly
AANUM_1663	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AANUM_1664	COG1525	nuclease
AANUM_1667	COG4774	siderophore transport
AANUM_1671	COG1120	ATPase activity
AANUM_1676	COG3585	molybdate ion transport
AANUM_1678	COG1120	ATPase activity
AANUM_1685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AANUM_1686	COG0315	cyclic pyranopterin monophosphate synthase activity
AANUM_1687	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AANUM_1688	COG0314	molybdopterin synthase activity
AANUM_1690	COG2969	positive regulation of protein catabolic process
AANUM_1692	COG1940	carbohydrate kinase activity
AANUM_1693	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AANUM_1694	COG1070	Carbohydrate kinase
AANUM_1695	COG2390	Transcriptional regulator
AANUM_1702	COG0469	pyruvate kinase activity
AANUM_1704	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AANUM_1706	COG0133	tryptophan synthase activity
AANUM_1707	COG4221	oxidoreductase activity
AANUM_1709	COG1629	transport
AANUM_1709	COG4771	TonB-dependent receptor
AANUM_1710	COG1629	transport
AANUM_1710	COG4771	TonB-dependent receptor
AANUM_1713	COG3630	sodium ion export across plasma membrane
AANUM_1716	COG0298	carbon dioxide binding
AANUM_1718	COG0135	phosphoribosylanthranilate isomerase activity
AANUM_1718	COG0134	indole-3-glycerol-phosphate synthase activity
AANUM_1719	COG0134	indole-3-glycerol-phosphate synthase activity
AANUM_1719	COG0135	phosphoribosylanthranilate isomerase activity
AANUM_1720	COG3093	addiction module antidote protein HigA
AANUM_1722	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AANUM_1723	COG1942	4-Oxalocrotonate Tautomerase
AANUM_1724	COG0512	Glutamine amidotransferase of anthranilate synthase
AANUM_1725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AANUM_1726	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AANUM_1727	COG0517	IMP dehydrogenase activity
AANUM_1727	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AANUM_1731	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AANUM_1734	COG0791	NLP P60 protein
AANUM_1737	COG0842	Transport permease protein
AANUM_1738	COG1129	ABC transporter
AANUM_1738	COG0842	Transport permease protein
AANUM_1739	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AANUM_1741	COG1448	Aminotransferase
AANUM_1742	COG0308	aminopeptidase N
AANUM_1743	COG0167	dihydroorotate dehydrogenase activity
AANUM_1744	COG0613	PHP domain protein
AANUM_1745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AANUM_1746	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
AANUM_1747	COG0589	response to stress
AANUM_1748	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AANUM_1750	COG1528	Iron-storage protein
AANUM_1751	COG1528	Iron-storage protein
AANUM_1752	COG2925	Exonuclease
AANUM_1753	COG0697	spore germination
AANUM_1754	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AANUM_1755	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AANUM_1756	COG0204	Acyl-transferase
AANUM_1756	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_1757	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AANUM_1758	COG1686	Belongs to the peptidase S11 family
AANUM_1760	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AANUM_1761	COG0586	Pfam SNARE associated Golgi protein
AANUM_1762	COG0058	SHG alpha-glucan phosphorylase activity
AANUM_1765	COG1523	belongs to the glycosyl hydrolase 13 family
AANUM_1770	COG3179	chitinase
AANUM_1774	COG3657	addiction module killer protein
AANUM_1777	COG1346	cytolysis
AANUM_1780	COG2826	transposase and inactivated derivatives, IS30 family
AANUM_1782	COG3293	Transposase
AANUM_1786	COG3005	denitrification pathway
AANUM_1787	COG0243	molybdopterin cofactor binding
AANUM_1788	COG2315	Protein conserved in bacteria
AANUM_1789	COG0471	metal ion transport
AANUM_1793	COG0101	tRNA pseudouridine synthase activity
AANUM_1797	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AANUM_1798	COG1074	ATP-dependent DNA helicase activity
AANUM_1799	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AANUM_1800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AANUM_1801	COG1067	ATP-dependent peptidase activity
AANUM_1803	COG1278	Cold shock
AANUM_1806	COG3098	single-species biofilm formation
AANUM_1807	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AANUM_1813	COG2801	Transposase and inactivated derivatives
AANUM_1814	COG2801	Transposase and inactivated derivatives
AANUM_1815	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_1818	COG3842	ATPase activity
AANUM_1819	COG1178	ABC-type Fe3 transport system permease component
AANUM_1820	COG3842	ATPase activity
AANUM_1821	COG3101	peptidyl-lysine hydroxylation
AANUM_1822	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AANUM_1824	COG0788	formyltetrahydrofolate deformylase activity
AANUM_1825	COG2916	Histone family protein nucleoid-structuring protein H-NS
AANUM_1826	COG1757	Na H antiporter
AANUM_1827	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AANUM_1829	COG0251	oxidation-reduction process
AANUM_1832	COG0463	Glycosyl transferase, family 2
AANUM_1833	COG3021	interspecies interaction between organisms
AANUM_1834	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AANUM_1836	COG1560	Kdo2-lipid A biosynthetic process
AANUM_1837	COG0730	response to heat
AANUM_1838	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AANUM_1839	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AANUM_1840	COG3264	Mechanosensitive ion channel
AANUM_1840	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AANUM_1841	COG0318	PFAM AMP-dependent synthetase and ligase
AANUM_1842	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AANUM_1843	COG0596	Alpha beta hydrolase
AANUM_1844	COG0716	FMN binding
AANUM_1845	COG0735	belongs to the Fur family
AANUM_1846	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AANUM_1847	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AANUM_1848	COG3094	Invasion gene expression up-regulator, SirB
AANUM_1849	COG0023	Translation Initiation Factor
AANUM_1851	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AANUM_1852	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AANUM_1853	COG0776	regulation of translation
AANUM_1854	COG0539	negative regulation of cytoplasmic translation
AANUM_1856	COG2990	Protein conserved in bacteria
AANUM_1857	COG4771	TonB-dependent receptor
AANUM_1858	COG2932	Transcriptional regulator
AANUM_1860	COG3423	Transcriptional regulator
AANUM_1861	COG2801	Transposase and inactivated derivatives
AANUM_1862	COG2842	Transposition protein
AANUM_1876	COG4382	Mu-like prophage protein Gp16
AANUM_1877	COG5566	PFAM Mor transcription activator
AANUM_1878	COG3023	N-Acetylmuramoyl-L-alanine amidase
AANUM_1884	COG0640	Transcriptional regulator
AANUM_1886	COG4373	Mu-like prophage FluMu protein gp28
AANUM_1887	COG4383	Mu-like prophage protein gp29
AANUM_1888	COG2369	cell adhesion
AANUM_1889	COG5005	Phage virion morphogenesis
AANUM_1890	COG4388	Caudovirus prohead serine protease
AANUM_1891	COG4397	Mu-like prophage major head subunit gpT
AANUM_1893	COG4387	Mu-like prophage protein GP36
AANUM_1894	COG5003	unkown
AANUM_1908	COG3392	D12 class N6 adenine-specific DNA methyltransferase
AANUM_1913	COG4771	TonB-dependent receptor
AANUM_1914	COG0612	Peptidase, M16
AANUM_1915	COG1687	branched-chain amino acid
AANUM_1916	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AANUM_1917	COG0583	DNA-binding transcription factor activity
AANUM_1919	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AANUM_1920	COG1518	maintenance of DNA repeat elements
AANUM_1929	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
AANUM_1930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AANUM_1931	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AANUM_1934	COG0405	Gamma-glutamyltransferase
AANUM_1935	COG0642	Histidine kinase
AANUM_1936	COG0642	Histidine kinase
AANUM_1937	COG0745	RESPONSE REGULATOR receiver
AANUM_1938	COG0745	RESPONSE REGULATOR receiver
AANUM_1941	COG0737	Belongs to the 5'-nucleotidase family
AANUM_1942	COG4607	ABC-type enterochelin transport system periplasmic component
AANUM_1943	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AANUM_1944	COG4605	iron ion homeostasis
AANUM_1945	COG4604	ABC transporter, ATP-binding protein
AANUM_1946	COG0739	heme binding
AANUM_1948	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_1949	COG0733	neurotransmitter:sodium symporter activity
AANUM_1950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AANUM_1956	COG4657	Part of a membrane complex involved in electron transport
AANUM_1957	COG1090	epimerase
AANUM_1958	COG1438	arginine binding
AANUM_1959	COG0039	L-malate dehydrogenase activity
AANUM_1961	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AANUM_1962	COG0583	DNA-binding transcription factor activity
AANUM_1964	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AANUM_1965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AANUM_1965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AANUM_1966	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AANUM_1968	COG0471	metal ion transport
AANUM_1969	COG2005	Transcriptional regulator
AANUM_1970	COG0725	ABC transporter, periplasmic molybdate-binding protein
AANUM_1971	COG4149	molybdate abc transporter
AANUM_1972	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AANUM_1974	COG0795	lipopolysaccharide-transporting ATPase activity
AANUM_1975	COG0795	lipopolysaccharide-transporting ATPase activity
AANUM_1976	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AANUM_1977	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AANUM_1982	COG0309	Hydrogenase expression formation protein (HypE)
AANUM_1983	COG0409	Hydrogenase expression formation protein
AANUM_1984	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AANUM_1985	COG1122	ATPase activity
AANUM_1986	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AANUM_1987	COG0310	cobalt ion transport
AANUM_1988	COG0310	cobalt ion transport
AANUM_1989	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
AANUM_1990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AANUM_1991	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_1992	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AANUM_1993	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AANUM_1995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AANUM_1999	COG2271	Major facilitator Superfamily
AANUM_2001	COG3718	enzyme involved in inositol metabolism
AANUM_2005	COG3501	Rhs element vgr protein
AANUM_2007	COG1609	Transcriptional regulator
AANUM_2008	COG2949	membrane
AANUM_2009	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AANUM_2013	COG0583	DNA-binding transcription factor activity
AANUM_2015	COG0009	L-threonylcarbamoyladenylate synthase
AANUM_2016	COG0287	Prephenate dehydrogenase
AANUM_2016	COG1605	Chorismate mutase
AANUM_2017	COG0616	signal peptide processing
AANUM_2018	COG0778	Nitroreductase
AANUM_2019	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AANUM_2020	COG0508	dehydrogenase complex catalyzes the overall conversion of
AANUM_2021	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AANUM_2023	COG2909	trisaccharide binding
AANUM_2024	COG0058	SHG alpha-glucan phosphorylase activity
AANUM_2025	COG1640	4-alpha-glucanotransferase
AANUM_2026	COG1286	toxin biosynthetic process
AANUM_2027	COG3092	negative regulation of chromosome organization
AANUM_2028	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AANUM_2029	COG0280	phosphate acetyltransferase
AANUM_2029	COG0857	belongs to the CobB CobQ family
AANUM_2031	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AANUM_2032	COG0617	tRNA 3'-terminal CCA addition
AANUM_2033	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AANUM_2034	COG0658	competence protein
AANUM_2034	COG2333	competence protein COMEC
AANUM_2035	COG1132	(ABC) transporter
AANUM_2036	COG1663	tetraacyldisaccharide 4'-kinase activity
AANUM_2037	COG2835	tetraacyldisaccharide 4'-kinase activity
AANUM_2039	COG0322	excinuclease ABC activity
AANUM_2041	COG0395	ABC-type sugar transport system, permease component
AANUM_2042	COG1175	transmembrane transport
AANUM_2045	COG3177	Filamentation induced by cAMP protein fic
AANUM_2049	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AANUM_2050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AANUM_2052	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AANUM_2055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AANUM_2058	COG0195	Participates in both transcription termination and antitermination
AANUM_2062	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AANUM_2062	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AANUM_2063	COG0516	GMP reductase activity
AANUM_2063	COG0517	IMP dehydrogenase activity
AANUM_2065	COG2932	Transcriptional regulator
AANUM_2068	COG2801	Transposase and inactivated derivatives
AANUM_2069	COG2801	Transposase and inactivated derivatives
AANUM_2070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AANUM_2071	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AANUM_2073	COG2062	phosphohistidine phosphatase, SixA
AANUM_2076	COG3100	YcgL domain-containing protein
AANUM_2078	COG0791	NLP P60 protein
AANUM_2080	COG2890	protein-(glutamine-N5) methyltransferase activity
AANUM_2081	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AANUM_2082	COG3133	Outer membrane lipoprotein
AANUM_2083	COG3102	Protein conserved in bacteria
AANUM_2085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AANUM_2086	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AANUM_2087	COG4178	(ABC) transporter
AANUM_2088	COG4774	siderophore transport
AANUM_2090	COG0307	riboflavin synthase, alpha
AANUM_2091	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AANUM_2092	COG3657	addiction module killer protein
AANUM_2093	COG1534	Rna-binding protein
AANUM_2094	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AANUM_2095	COG2027	D-alanyl-D-alanine carboxypeptidase
AANUM_2097	COG0303	'Molybdopterin
AANUM_2098	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AANUM_2099	COG3118	belongs to the thioredoxin family
AANUM_2100	COG0492	ferredoxin-NADP+ reductase activity
AANUM_2101	COG4988	ABC transporter
AANUM_2102	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AANUM_2103	COG1946	Acyl-CoA thioesterase
AANUM_2104	COG0515	serine threonine protein kinase
AANUM_2107	COG1943	Transposase
AANUM_2108	COG1940	carbohydrate kinase activity
AANUM_2109	COG0671	phosphoesterase, PA-phosphatase related
AANUM_2112	COG1088	dTDP-glucose 4,6-dehydratase activity
AANUM_2114	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
AANUM_2115	COG0708	Exodeoxyribonuclease III
AANUM_2124	COG1682	transport, permease protein
AANUM_2129	COG2951	lytic endotransglycosylase activity
AANUM_2130	COG1216	Glycosyl transferase, family 2
AANUM_2131	COG1216	Glycosyl transferase, family 2
AANUM_2133	COG3306	glycosyltransferase involved in LPS biosynthesis
AANUM_2135	COG5039	Polysaccharide pyruvyl transferase
AANUM_2136	COG2161	toxin-antitoxin pair type II binding
AANUM_2137	COG4115	mRNA cleavage
AANUM_2138	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AANUM_2139	COG1793	dna ligase
AANUM_2140	COG0210	DNA helicase
AANUM_2141	COG2610	gluconate transmembrane transporter activity
AANUM_2142	COG3265	gluconokinase activity
AANUM_2143	COG1609	Transcriptional regulator
AANUM_2147	COG0437	4 iron, 4 sulfur cluster binding
AANUM_2148	COG2864	formate dehydrogenase
AANUM_2149	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AANUM_2150	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AANUM_2151	COG0651	ATP synthesis coupled electron transport
AANUM_2152	COG0650	Formate hydrogenlyase subunit 4
AANUM_2153	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AANUM_2154	COG4237	Hydrogenase 4 membrane
AANUM_2155	COG0651	ATP synthesis coupled electron transport
AANUM_2156	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
AANUM_2156	COG3261	NADH dehydrogenase
AANUM_2157	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AANUM_2158	COG3260	NADH ubiquinone oxidoreductase 20
AANUM_2160	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AANUM_2162	COG3383	formate dehydrogenase (NAD+) activity
AANUM_2163	COG3383	formate dehydrogenase (NAD+) activity
AANUM_2167	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AANUM_2169	COG0508	dehydrogenase complex catalyzes the overall conversion of
AANUM_2170	COG0567	Dehydrogenase, E1 component
AANUM_2171	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AANUM_2172	COG3108	Peptidase M15
AANUM_2173	COG2989	Protein conserved in bacteria
AANUM_2174	COG0793	Belongs to the peptidase S41A family
AANUM_2175	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AANUM_2176	COG2995	paraquat-inducible protein a
AANUM_2177	COG3008	intermembrane lipid transfer
AANUM_2178	COG3008	intermembrane lipid transfer
AANUM_2180	COG3842	ATPase activity
AANUM_2181	COG1176	ABC-type spermidine putrescine transport system, permease component I
AANUM_2182	COG1177	transmembrane transport
AANUM_2183	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AANUM_2186	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AANUM_2187	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AANUM_2190	COG1522	sequence-specific DNA binding
AANUM_2192	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AANUM_2193	COG1178	ABC-type Fe3 transport system permease component
AANUM_2194	COG4143	(ABC) transporter
AANUM_2195	COG0351	phosphomethylpyrimidine kinase
AANUM_2195	COG0351	phosphomethylpyrimidine kinase
AANUM_2204	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AANUM_2207	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AANUM_2209	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AANUM_2213	COG2920	part of a sulfur-relay system
AANUM_2216	COG1121	(ABC) transporter
AANUM_2217	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_2218	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AANUM_2221	COG1803	Methylglyoxal synthase
AANUM_2222	COG3304	Inner membrane component domain
AANUM_2223	COG1289	transmembrane transporter activity
AANUM_2226	COG3958	Transketolase
AANUM_2227	COG3959	Transketolase, thiamine diphosphate binding domain
AANUM_2236	COG3501	Rhs element vgr protein
AANUM_2238	COG4953	penicillin-binding protein 1C
AANUM_2239	COG2855	membrane
AANUM_2243	COG3842	ATPase activity
AANUM_2244	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AANUM_2245	COG0725	ABC transporter, periplasmic molybdate-binding protein
AANUM_2247	COG3676	manually curated
AANUM_2248	COG5339	Protein conserved in bacteria
AANUM_2249	COG0443	Heat shock 70 kDa protein
AANUM_2250	COG0484	heat shock protein binding
AANUM_2251	COG2337	Toxic component of a toxin-antitoxin (TA) module
AANUM_2254	COG0626	cystathionine gamma-synthase activity
AANUM_2255	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AANUM_2257	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AANUM_2258	COG2999	glutathione oxidoreductase activity
AANUM_2259	COG1530	ribonuclease E activity
AANUM_2260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AANUM_2270	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_2271	COG1840	ABC-type Fe3 transport system, periplasmic component
AANUM_2276	COG2801	Transposase and inactivated derivatives
AANUM_2278	COG2860	membrane
AANUM_2281	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AANUM_2282	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AANUM_2283	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AANUM_2284	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AANUM_2285	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AANUM_2286	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AANUM_2289	COG2914	Belongs to the UPF0125 (RnfH) family
AANUM_2290	COG2850	peptidyl-arginine hydroxylation
AANUM_2291	COG1570	exodeoxyribonuclease VII activity
AANUM_2293	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AANUM_2294	COG1137	ATPase activity
AANUM_2295	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AANUM_2296	COG3117	lipopolysaccharide transmembrane transporter activity
AANUM_2297	COG1127	ABC transporter
AANUM_2298	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AANUM_2299	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AANUM_2300	COG2854	intermembrane phospholipid transfer
AANUM_2301	COG3113	response to antibiotic
AANUM_2302	COG5007	Belongs to the BolA IbaG family
AANUM_2304	COG3691	Protein conserved in bacteria
AANUM_2306	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AANUM_2308	COG0861	Integral membrane protein TerC family
AANUM_2311	COG3468	outer membrane autotransporter barrel domain protein
AANUM_2311	COG3266	domain, Protein
AANUM_2312	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AANUM_2313	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AANUM_2317	COG1125	glycine betaine transport
AANUM_2317	COG0517	IMP dehydrogenase activity
AANUM_2318	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AANUM_2320	COG0460	homoserine dehydrogenase
AANUM_2320	COG0527	aspartate kinase activity
AANUM_2323	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AANUM_2324	COG2091	lysine biosynthetic process via aminoadipic acid
AANUM_2325	COG0330	HflC and HflK could
AANUM_2326	COG0330	HflC and HflK could
AANUM_2327	COG0544	peptidyl-prolyl cis-trans isomerase activity
AANUM_2328	COG4974	Belongs to the 'phage' integrase family
AANUM_2329	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AANUM_2332	COG3061	Opacity-associated protein A
AANUM_2332	COG3266	domain, Protein
AANUM_2333	COG1509	lysine 2,3-aminomutase activity
AANUM_2335	COG3033	Beta-eliminating lyase
AANUM_2336	COG0814	amino acid
AANUM_2337	COG2964	Protein conserved in bacteria
AANUM_2338	COG5413	integral membrane protein
AANUM_2340	COG0204	Acyl-transferase
AANUM_2342	COG0697	spore germination
AANUM_2343	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AANUM_2344	COG1882	Formate acetyltransferase
AANUM_2345	COG1882	Formate acetyltransferase
AANUM_2346	COG2116	formate transmembrane transporter activity
AANUM_2347	COG0537	adenosine 5'-monophosphoramidase activity
AANUM_2351	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AANUM_2356	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AANUM_2359	COG0681	Belongs to the peptidase S26 family