locus-tag class description NT05HA_0004 ENOG4105HDK L-asparaginase NT05HA_0006 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs NT05HA_0008 ENOG41090FY type IV pilus biogenesis stability protein PilW NT05HA_0009 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) NT05HA_0010 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) NT05HA_0011 ENOG4105CUT histidyl-tRNA synthetase NT05HA_0012 ENOG4105N21 Membrane NT05HA_0014 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) NT05HA_0015 ENOG4105C2W permease NT05HA_0016 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) NT05HA_0017 ENOG4105EIN peptidylprolyl cis-trans isomerase NT05HA_0018 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) NT05HA_0020 ENOG4105CHH sulfate transporter NT05HA_0021 ENOG4108UHU Aldolase NT05HA_0022 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NT05HA_0023 ENOG4105C6K Malic enzyme NT05HA_0024 ENOG4105I08 Pseudouridine synthase NT05HA_0025 ENOG4105C2C drug resistance transporter, Bcr CflA NT05HA_0026 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) NT05HA_0027 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) NT05HA_0028 ENOG41060IM Heme exporter protein NT05HA_0029 ENOG4105X3C heme exporter protein NT05HA_0030 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) NT05HA_0031 ENOG4105DA4 cytochrome c-type biogenesis protein NT05HA_0032 ENOG4107QX9 Thiol disulfide interChange protein NT05HA_0033 ENOG4108M1T Cytochrome c-type biogenesis protein NT05HA_0034 ENOG4108M1T Cytochrome c-type biogenesis protein NT05HA_0038 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit NT05HA_0039 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein NT05HA_0040 ENOG4105DVI reductase, NrfD NT05HA_0041 ENOG4105DA4 cytochrome c-type biogenesis protein NT05HA_0042 ENOG4107QX9 Thiol disulfide interChange protein NT05HA_0043 ENOG4108DMF Cytochrome C biogenesis protein NT05HA_0044 ENOG4105CBX hi0933 family NT05HA_0045 ENOG4105C94 Transporter NT05HA_0046 ENOG4108KS2 transglutaminase domain protein NT05HA_0048 ENOG410681U heavy metal transport detoxification protein NT05HA_0049 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NT05HA_0050 ENOG4105DVA methyltransferase NT05HA_0051 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) NT05HA_0052 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NT05HA_0053 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) NT05HA_0055 ENOG4105VG0 50S ribosomal protein l34 NT05HA_0056 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) NT05HA_0060 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) NT05HA_0062 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) NT05HA_0064 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase NT05HA_0066 ENOG4108IQE Amp-dependent synthetase and ligase NT05HA_0068 ENOG4105C0B DNA polymerase III (alpha subunit) NT05HA_0069 ENOG4105E7A Glutamine amidotransferase NT05HA_0070 ENOG4105D82 Glutamate dehydrogenase NT05HA_0072 ENOG4105CH7 arginosuccinase NT05HA_0073 ENOG4108ST3 glycosyltransferase NT05HA_0077 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) NT05HA_0079 ENOG4105VEQ Cold shock protein NT05HA_0080 ENOG4108RVA ribokinase NT05HA_0081 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) NT05HA_0082 ENOG4105HF0 Membrane NT05HA_0084 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) NT05HA_0085 ENOG4108Z6B deaminase NT05HA_0086 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) NT05HA_0087 ENOG4105XCT Protein of unknown function (DUF2489) NT05HA_0088 ENOG4105D4P Coproporphyrinogen iii oxidase NT05HA_0089 ENOG4108HYK gCN5-related N-acetyltransferase NT05HA_0090 ENOG4105CP7 Triose-phosphate isomerase NT05HA_0091 ENOG4108IPT Naphthoate synthase NT05HA_0092 ENOG4105DNI Converts SHCHC to OSB (By similarity) NT05HA_0093 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) NT05HA_0094 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein NT05HA_0095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase NT05HA_0098 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) NT05HA_0099 ENOG4105C3F Signal peptidase i NT05HA_0100 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) NT05HA_0102 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) NT05HA_0103 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) NT05HA_0106 ENOG41076HS cation diffusion facilitator family transporter NT05HA_0107 ENOG4105CTQ phosphohexokinase NT05HA_0108 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) NT05HA_0109 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) NT05HA_0111 ENOG4105K59 histidine triad (HIT) protein NT05HA_0112 ENOG4105TMB Formate nitrite transporter NT05HA_0113 ENOG4105C6N Formate acetyltransferase NT05HA_0115 ENOG4105F1A Pyruvate formate-lyase NT05HA_0118 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) NT05HA_0119 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase NT05HA_0120 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) NT05HA_0122 ENOG4105WWK YheO domain protein NT05HA_0123 ENOG4105E0U tyrosine-specific transport protein NT05HA_0124 ENOG4105C0F tryptophanase EC 4.1.99.1 NT05HA_0126 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein NT05HA_0127 ENOG4108UBT opacity-associated protein NT05HA_0132 ENOG4105II7 pyrroline-5-carboxylate reductase NT05HA_0133 ENOG4105D8G Major Facilitator superfamily NT05HA_0134 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NT05HA_0135 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation NT05HA_0136 ENOG4105EPW hflc protein NT05HA_0137 ENOG4107QJR hflk protein NT05HA_0138 ENOG4105W8Z 4'-phosphopantetheinyl transferase NT05HA_0139 ENOG4105D98 threonine synthase NT05HA_0146 ENOG4105DFA alanine racemase domain protein NT05HA_0147 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) NT05HA_0148 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NT05HA_0149 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen NT05HA_0154 ENOG4105CI3 gtp-binding protein typa NT05HA_0155 ENOG4105C5F glutamine synthetase NT05HA_0156 ENOG4105EE5 Membrane protein terC NT05HA_0158 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) NT05HA_0159 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation NT05HA_0160 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation NT05HA_0161 ENOG4105KZW UPF0381 protein NT05HA_0162 ENOG4105C8P )-transporter NT05HA_0164 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) NT05HA_0165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase NT05HA_0166 ENOG4108R96 Methyltransferase, YaeB family NT05HA_0167 ENOG4108Z6Z Transcriptional regulator NT05HA_0170 ENOG4105C59 p-type ATPase NT05HA_0171 ENOG4105NX3 Membrane NT05HA_0172 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) NT05HA_0173 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) NT05HA_0175 ENOG4108I6E Sulfatase NT05HA_0176 ENOG4105D9M gamma-glutamylcysteine synthetase NT05HA_0191 ENOG4105C9A Phoh family NT05HA_0192 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) NT05HA_0196 ENOG4108JA2 transcriptioN-repair coupling factor NT05HA_0199 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) NT05HA_0201 ENOG4105E5Z arginine transporter ATP-binding subunit NT05HA_0202 ENOG4106PMH Extracellular solute-binding protein family 3 NT05HA_0203 ENOG4105GBT ABC transporter NT05HA_0204 ENOG4105DMR ABC, transporter NT05HA_0205 ENOG4106PMH Extracellular solute-binding protein family 3 NT05HA_0206 ENOG4106PMH Extracellular solute-binding protein family 3 NT05HA_0209 ENOG4108V6E Cell division protein mraZ NT05HA_0210 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) NT05HA_0212 ENOG4105CJN penicillin-binding protein NT05HA_0213 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) NT05HA_0214 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) NT05HA_0215 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) NT05HA_0216 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) NT05HA_0217 ENOG4105CNI cell division protein FtsW NT05HA_0218 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) NT05HA_0219 ENOG4105DFU Cell wall formation (By similarity) NT05HA_0221 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) NT05HA_0222 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) NT05HA_0223 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) NT05HA_0224 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NT05HA_0227 ENOG4105CQC Prephenate dehydratase NT05HA_0230 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) NT05HA_0231 ENOG4105KUZ arsenate reductase NT05HA_0236 ENOG41087AY ADP-Ribose pyrophosphatase NT05HA_0237 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) NT05HA_0238 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) NT05HA_0240 ENOG4105CFP Peptidase U32 NT05HA_0243 ENOG4107RZZ dna polymerase iii epsilon subunit NT05HA_0245 ENOG4107QPK )-transporter NT05HA_0246 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase NT05HA_0247 ENOG4105CHY citrate lyase, alpha NT05HA_0248 ENOG4105CI0 Citrate lyase NT05HA_0250 ENOG4105DUA (citrate (pro-3S)-lyase ligase NT05HA_0251 ENOG4108JU5 Magnesium and cobalt efflux protein NT05HA_0252 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) NT05HA_0254 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) NT05HA_0255 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) NT05HA_0256 ENOG4107QQG Dehydrogenase NT05HA_0259 ENOG4105CS6 Rhs element vgr protein NT05HA_0261 ENOG4107TV1 YD repeat protein NT05HA_0265 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis NT05HA_0267 ENOG4105CK7 Sodium proline symporter NT05HA_0268 ENOG4105C03 ribonuclease NT05HA_0269 ENOG4105E9S glutaredoxin 2 NT05HA_0270 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) NT05HA_0272 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein NT05HA_0274 ENOG4108VEN abc transporter atp-binding protein NT05HA_0275 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase NT05HA_0276 ENOG4105D1U peptidase U62 modulator of DNA gyrase NT05HA_0277 ENOG4105DN3 alpha-2-macroglobulin domain protein NT05HA_0278 ENOG4108JQB penicillin-binding protein 1C NT05HA_0288 ENOG4105CS6 Rhs element vgr protein NT05HA_0292 ENOG4105CS6 Rhs element vgr protein NT05HA_0296 ENOG4107R6U sodium dicarboxylate symporter NT05HA_0297 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) NT05HA_0298 ENOG4108M8S permease YjgP YjgQ family protein NT05HA_0299 ENOG4108K5H permease YjgP YjgQ family protein NT05HA_0300 ENOG4105SYT Methylenetetrahydrofolate reductase NT05HA_0302 ENOG4105FAV ABC, transporter NT05HA_0303 ENOG4105FDK ABC transporter NT05HA_0305 ENOG4105DR5 peptidase NT05HA_0308 ENOG4108KXH Ybak prolyl-tRNA synthetase associated NT05HA_0309 ENOG4105C5T Phosphoribosyl pyrophosphate synthase NT05HA_0314 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate NT05HA_0316 ENOG4105CJ3 phosphate transporter NT05HA_0317 ENOG4107IX6 phosphate transport regulator NT05HA_0318 ENOG4105I7R Adenylate cyclase NT05HA_0319 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) NT05HA_0320 ENOG4105EW9 transcriptional regulator AsnC family NT05HA_0323 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) NT05HA_0324 ENOG4105D1H recombination factor protein RarA NT05HA_0325 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter NT05HA_0327 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) NT05HA_0330 ENOG4105FB9 CRISPR-associated protein NT05HA_0335 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) NT05HA_0337 ENOG4105CI1 PTS System NT05HA_0339 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) NT05HA_0340 ENOG4107414 GntR family transcriptional regulator NT05HA_0341 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) NT05HA_0342 ENOG4105DZ2 Transcriptional regulator NT05HA_0344 ENOG4108UMN azlc family NT05HA_0345 ENOG4105KMT branched-chain amino acid NT05HA_0346 ENOG4107RAN Peptidase, M16 NT05HA_0347 ENOG4105PE1 Receptor NT05HA_0348 ENOG4108MJ5 VirK protein NT05HA_0349 ENOG4105CAT Cytidine monophosphate kinase NT05HA_0350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) NT05HA_0351 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) NT05HA_0352 ENOG4105Q4A inner membrane protein yciS NT05HA_0353 ENOG4105CFV Tetratricopeptide repeat protein NT05HA_0356 ENOG4108ZJT translation initiation factor, Sui1 NT05HA_0358 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT05HA_0359 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) NT05HA_0360 ENOG41090R7 Ferric uptake NT05HA_0361 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) NT05HA_0362 ENOG4105NNH LexA regulated protein NT05HA_0363 ENOG4105EV9 Alpha Beta Hydrolase NT05HA_0364 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) NT05HA_0365 ENOG4105CEY Amp-dependent synthetase and ligase NT05HA_0366 ENOG4105EGS Mechanosensitive ion channel NT05HA_0368 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) NT05HA_0369 ENOG4105EJ9 Membrane NT05HA_0370 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase NT05HA_0371 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) NT05HA_0372 ENOG4107QMP dna polymerase iii subunits gamma and tau NT05HA_0373 ENOG4107NA1 Endonuclease Exonuclease phosphatase NT05HA_0374 ENOG4105M4H endoribonuclease L-psp NT05HA_0375 ENOG4108VTV Inherit from NOG: Membrane NT05HA_0379 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH NT05HA_0380 ENOG4107QNR UPF0135 protein NT05HA_0381 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) NT05HA_0382 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase NT05HA_0385 ENOG4105D29 Helix-turn-helix type 11 domain protein NT05HA_0387 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) NT05HA_0388 ENOG4108DG9 Smr protein MutS2 NT05HA_0389 ENOG4105EM2 membrane NT05HA_0390 ENOG410901E Membrane NT05HA_0391 ENOG4108Z5K methylglyoxal synthase NT05HA_0392 ENOG41068P6 UPF0319 protein NT05HA_0393 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 NT05HA_0394 ENOG4105CC5 ABC transporter NT05HA_0395 ENOG4105CC5 ABC transporter NT05HA_0396 ENOG4105DIK (ABC) transporter NT05HA_0398 ENOG4108Z0T Part of a sulfur-relay system (By similarity) NT05HA_0399 ENOG4108MN8 Membrane NT05HA_0400 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III NT05HA_0402 ENOG4105DDY UPF0142 protein ycaO NT05HA_0403 ENOG4105EIP mannose-6-phosphate isomerase NT05HA_0404 ENOG4105KWI UPF0339 protein NT05HA_0405 ENOG4105CI1 PTS System NT05HA_0406 ENOG4105D1A Methyltransferase NT05HA_0409 ENOG4105E2R ROK family NT05HA_0414 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) NT05HA_0415 ENOG4106CC8 Bacterial inner membrane protein NT05HA_0416 ENOG4105CDH Citrulline--aspartate ligase NT05HA_0417 ENOG4108535 NAD dependent epimerase/dehydratase family NT05HA_0421 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) NT05HA_0422 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) NT05HA_0423 ENOG4107RUE extracellular solute-binding protein family 1 NT05HA_0424 ENOG4105D38 putrescine abc transporter NT05HA_0425 ENOG4105F38 ABC transporter, permease NT05HA_0426 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_0427 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) NT05HA_0428 ENOG4105DY2 Paraquat-inducible protein b NT05HA_0430 ENOG4105H2K paraquat-inducible protein a NT05HA_0431 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) NT05HA_0434 ENOG4105DIT ErfK YbiS YcfS YnhG family protein NT05HA_0435 ENOG4105EAQ (twin-arginine translocation) pathway signal NT05HA_0436 ENOG4105C5X domain protein NT05HA_0437 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 NT05HA_0438 ENOG4105C7S Dehydrogenase NT05HA_0440 ENOG4105CMV Succinyl-CoA synthetase subunit beta NT05HA_0441 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha NT05HA_0450 ENOG4105XJC Two component transcriptional regulator (Winged helix family NT05HA_0451 ENOG4105DHQ Histidine kinase NT05HA_0452 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) NT05HA_0453 ENOG4105EYM Major Facilitator superfamily NT05HA_0454 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) NT05HA_0455 ENOG4105CMR udp-glucose 4-epimerase NT05HA_0456 ENOG4105C7N Xanthine uracil vitamin C permease NT05HA_0458 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) NT05HA_0459 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) NT05HA_0460 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) NT05HA_0478 ENOG4108XTP Transcriptional regulator NT05HA_0482 ENOG4105CAR Terminase, large subunit NT05HA_0486 ENOG4105RWQ Protein of unknown function (DUF1364) NT05HA_0516 ENOG4105DFP Integrase NT05HA_0520 ENOG4105CEE C4-dicarboxylate transporter NT05HA_0521 ENOG4105C2W permease NT05HA_0524 ENOG4105EUR Domain-Containing protein NT05HA_0524 ENOG4105EUR Domain-Containing protein NT05HA_0529 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) NT05HA_0530 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase NT05HA_0532 ENOG4105DWF phosphomethylpyrimidine kinase NT05HA_0533 ENOG4105DP9 ABC transporter NT05HA_0534 ENOG4106SMU thiamine transporter membrane protein NT05HA_0535 ENOG4107T0D ABC, transporter NT05HA_0538 ENOG4107QMH DNA methylase NT05HA_0540 ENOG4105CI1 PTS System NT05HA_0543 ENOG4105CG6 trap dicarboxylate transporter dctm subunit NT05HA_0544 ENOG4108ERU trap dicarboxylate transporter subunit DctP NT05HA_0545 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) NT05HA_0547 ENOG4105QEK Transcriptional regulator NT05HA_0548 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NT05HA_0549 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) NT05HA_0550 ENOG4105CE4 GlcNAc 6-P deacetylase NT05HA_0552 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) NT05HA_0554 ENOG4105KA0 thioesterase Superfamily protein NT05HA_0555 ENOG4105CQB FAD linked oxidase domain protein NT05HA_0557 ENOG4108V0P LemA family NT05HA_0560 ENOG4105M2J Glutaredoxin NT05HA_0561 ENOG4108VMM UPF0756 membrane protein NT05HA_0562 ENOG4105M08 Membrane NT05HA_0563 ENOG4105CQ7 ATP-dependent helicase NT05HA_0567 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NT05HA_0569 ENOG4107RBB ABC transporter, permease NT05HA_0572 ENOG4107SJW iron permease, FTR1 NT05HA_0573 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) NT05HA_0576 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) NT05HA_0577 ENOG4105DAA L-lactate NT05HA_0579 ENOG4105BZ4 penicillin-binding protein NT05HA_0580 ENOG4108ZIG UPF0231 protein NT05HA_0581 ENOG4108YX9 iron--sulfur cluster insertion protein erpA NT05HA_0582 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) NT05HA_0583 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) NT05HA_0584 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase NT05HA_0585 ENOG4105ESV Glycosyl transferase, family 4 NT05HA_0592 ENOG4108ZPB UPF0306 protein NT05HA_0594 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein NT05HA_0595 ENOG4108EU3 peptide transport system, permease NT05HA_0600 ENOG4108W0P ABC transporter NT05HA_0602 ENOG4105CM6 amino acid regulated cytosolic protein NT05HA_0603 ENOG4106K28 UPF0283 membrane protein NT05HA_0604 ENOG4108JU8 Transcriptional regulator NT05HA_0605 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) NT05HA_0607 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) NT05HA_0609 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) NT05HA_0610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase NT05HA_0611 ENOG4105K8N protein family UPF0079, ATPase NT05HA_0613 ENOG4108I6E Sulfatase NT05HA_0616 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) NT05HA_0617 ENOG4105KZ7 phosphocarrier protein hpr NT05HA_0618 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) NT05HA_0619 ENOG4105C5Y PTS System NT05HA_0620 ENOG4105DGW oligopeptidase A NT05HA_0621 ENOG4105WD1 Membrane NT05HA_0622 ENOG4107TSG Extracellular solute-binding protein, family 5 NT05HA_0626 ENOG4105EYK Phosphatidylglycerophosphatase B NT05HA_0627 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) NT05HA_0628 ENOG4108RYC glycosyltransferase NT05HA_0629 ENOG4105CVE Lytic murein transglycosylase NT05HA_0630 ENOG4105MFV ABC-2 type transporter NT05HA_0632 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) NT05HA_0639 ENOG4105D3Q Sugar transferase NT05HA_0640 ENOG4105CGK Exodeoxyribonuclease III NT05HA_0641 ENOG4105GXY Family of unknown function (DUF695) NT05HA_0642 ENOG4105C1B dTDP-glucose 4-6-dehydratase NT05HA_0645 ENOG41069NU Nitroreductase NT05HA_0646 ENOG4105D07 Signal peptide peptidase, SppA NT05HA_0647 ENOG4105EHE chorismate mutase- prephenate dehydrogenase NT05HA_0648 ENOG4107RTD sua5 ycio yrdc ywlc family protein NT05HA_0650 ENOG4105FE9 pseudouridine synthase NT05HA_0651 ENOG4107R11 Transcriptional regulator NT05HA_0654 ENOG4105VT2 5-hydroxyisourate hydrolase NT05HA_0656 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) NT05HA_0657 ENOG4107QSN dihydrolipoamide acetyltransferase NT05HA_0658 ENOG4107QN2 dihydrolipoyl dehydrogenase NT05HA_0661 ENOG4105CRQ synthase (Component I) NT05HA_0662 ENOG4105DDQ anthranilate synthase NT05HA_0663 ENOG4105C5I Dehydrogenase NT05HA_0666 ENOG41090HT Inherit from COG: transposase NT05HA_0667 ENOG4108U1V ABC transporter, permease NT05HA_0670 ENOG41079CX NT05HA_0674 ENOG4105C3R Methionine synthase NT05HA_0675 ENOG4105D60 lipoprotein releasing system transmembrane protein NT05HA_0677 ENOG4105D60 lipoprotein releasing system transmembrane protein NT05HA_0680 ENOG4105CDU Replicative dna helicase NT05HA_0681 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NT05HA_0682 ENOG4107QP8 phosphohexose isomerase NT05HA_0683 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) NT05HA_0684 ENOG4107YIM Involved in the transcription termination process (By similarity) NT05HA_0685 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) NT05HA_0686 ENOG4108ZAI phosphatidylglycerophosphatase a NT05HA_0687 ENOG4105CCF Lysine exporter protein (Lyse ygga) NT05HA_0689 ENOG4105XPH Ferredoxin NT05HA_0690 ENOG4105C8P )-transporter NT05HA_0691 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT05HA_0693 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT05HA_0695 ENOG4105C4Y ABC transporter NT05HA_0696 ENOG4107RCV ABC transporter, permease NT05HA_0697 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_0698 ENOG4108Z66 YbaK ebsC protein NT05HA_0701 ENOG4105TWJ Domain of unknown function (DUF1919) NT05HA_0702 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen NT05HA_0703 ENOG4107QIV Cytochrome c biogenesis protein NT05HA_0704 ENOG4105E0X reductase NT05HA_0705 ENOG41077A9 carbonic anhydrase NT05HA_0706 ENOG4105W4M Transport-associated protein NT05HA_0707 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) NT05HA_0709 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) NT05HA_0710 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) NT05HA_0711 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) NT05HA_0712 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) NT05HA_0715 ENOG4105ERU peptidase NT05HA_0717 ENOG4105FGM Fructosamine kinase NT05HA_0719 ENOG4105C22 threonyL-tRNA synthetase NT05HA_0722 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) NT05HA_0723 ENOG41082NX 50s ribosomal protein l35 NT05HA_0724 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) NT05HA_0725 ENOG4108XC3 NADH ubiquinone oxidoreductase NT05HA_0727 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) NT05HA_0728 ENOG4105CTB Polyprenyl synthetase NT05HA_0729 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) NT05HA_0731 ENOG4105NIV Esterase NT05HA_0732 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) NT05HA_0733 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase NT05HA_0734 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) NT05HA_0735 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NT05HA_0736 ENOG4105DWU Membrane NT05HA_0737 ENOG4108W1A pseudouridine synthase NT05HA_0739 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA NT05HA_0744 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NT05HA_0745 ENOG4105DJY efflux transporter, rnd family, mfp subunit NT05HA_0747 ENOG4108ZZ3 UPF0260 protein NT05HA_0750 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) NT05HA_0751 ENOG4108ESZ Glycogen debranching enzyme NT05HA_0753 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) NT05HA_0754 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) NT05HA_0756 ENOG4108VD1 dedA family NT05HA_0759 ENOG41061WM D-Alanyl-D-Alanine NT05HA_0760 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) NT05HA_0762 ENOG4105CEY Amp-dependent synthetase and ligase NT05HA_0763 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) NT05HA_0764 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) NT05HA_0765 ENOG4108TZV Membrane NT05HA_0766 ENOG4105CJB Exodeoxyribonuclease I NT05HA_0767 ENOG41090A1 ferritin NT05HA_0768 ENOG41090A1 ferritin NT05HA_0770 ENOG4105DS0 Transcriptional regulator, Crp Fnr family NT05HA_0771 ENOG4105Q9Y Universal stress protein NT05HA_0773 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NT05HA_0774 ENOG4105CC0 LysR family Transcriptional regulator NT05HA_0775 ENOG4105DB7 PHP domain protein NT05HA_0777 ENOG4107XNU peptidase NT05HA_0779 ENOG4105CD8 aminopeptidase N NT05HA_0780 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) NT05HA_0781 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit NT05HA_0782 ENOG4105CGF Aromatic amino acid aminotransferase NT05HA_0783 ENOG4105EHG Permease protein NT05HA_0784 ENOG4105E0A ABC, transporter NT05HA_0786 ENOG4105X1Q TOBE domain protein NT05HA_0788 ENOG4108JGH Tetr family transcriptional regulator NT05HA_0789 ENOG4105D0S secretion protein (HlyD NT05HA_0792 ENOG4105CMI transporter NT05HA_0797 ENOG4108QBX (LipO)protein NT05HA_0798 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) NT05HA_0799 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) NT05HA_0800 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) NT05HA_0801 ENOG4105D0M Protease HtpX homolog NT05HA_0805 ENOG4105C2X Arabinose 5-phosphate isomerase NT05HA_0806 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase NT05HA_0807 ENOG4105CRQ synthase (Component I) NT05HA_0808 ENOG4105DDQ anthranilate synthase NT05HA_0809 ENOG4108V5Q transglutaminase-like protein NT05HA_0811 ENOG4105DK0 Indole-3-glycerol phosphate synthase NT05HA_0812 ENOG4105E3S small subunit NT05HA_0813 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein NT05HA_0814 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit NT05HA_0815 ENOG4105DPX Hydrogenase, large subunit NT05HA_0816 ENOG4108USZ hydrogenase NT05HA_0817 ENOG4108WGS hydrogenase 2-specific chaperone NT05HA_0822 ENOG4107QSA Oxaloacetate decarboxylase NT05HA_0823 ENOG4105D9Q decarboxylase (Beta subunit) NT05HA_0824 ENOG4105EMU Dehydrogenase NT05HA_0825 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) NT05HA_0827 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NT05HA_0829 ENOG4105CA9 Pyruvate kinase NT05HA_0831 ENOG41061GT Aldolase NT05HA_0832 ENOG4105D4B ABC, transporter NT05HA_0836 ENOG4105DKT Transcriptional regulator NT05HA_0839 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) NT05HA_0842 ENOG4105C5S asparaginyl-tRNA synthetase NT05HA_0843 ENOG4105KB2 stringent starvation protein b NT05HA_0844 ENOG4107MKT Stringent starvation protein a NT05HA_0845 ENOG4108ZAF Molybdopterin NT05HA_0846 ENOG4105M00 molybdopterin converting factor, subunit 1 NT05HA_0847 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NT05HA_0848 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NT05HA_0849 ENOG4105CHW UPF0052 protein NT05HA_0850 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) NT05HA_0851 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) NT05HA_0852 ENOG4108J2R molybdopterin oxidoreductase NT05HA_0853 ENOG4105CUW cytochrome C-TYPE protein NT05HA_0855 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) NT05HA_0856 ENOG4105CUW cytochrome C-TYPE protein NT05HA_0857 ENOG4107QY8 reductase NT05HA_0858 ENOG4105UNS Pfam:DUF419 NT05HA_0860 ENOG4105CG3 alpha amylase, catalytic region NT05HA_0861 ENOG4105C5Y PTS System NT05HA_0862 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) NT05HA_0866 ENOG4107QYX exodeoxyribonuclease v alpha NT05HA_0867 ENOG4107QKA exodeoxyribonuclease V beta NT05HA_0868 ENOG41090EX DsrE family NT05HA_0869 ENOG4105C7N Xanthine uracil vitamin C permease NT05HA_0871 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) NT05HA_0872 ENOG4105DAN ATP-dependent protease NT05HA_0873 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) NT05HA_0874 ENOG4105VEQ Cold shock protein NT05HA_0875 ENOG4105X5C UPF0181 protein NT05HA_0876 ENOG4105DR9 pseudouridine synthase NT05HA_0877 ENOG4105WP7 tRNA pseudouridine synthase C NT05HA_0878 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein NT05HA_0879 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) NT05HA_0880 ENOG4108BPE -transporting atpase NT05HA_0881 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NT05HA_0882 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) NT05HA_0883 ENOG4105CIY formyltetrahydrofolate deformylase NT05HA_0884 ENOG4108SAU DNA-binding protein H-ns NT05HA_0885 ENOG4107S6Z Na H antiporter NT05HA_0897 ENOG4107B7Y DNA-binding transcriptional regulator FruR NT05HA_0898 ENOG4107GZ4 SanA protein NT05HA_0899 ENOG4105DWV Homoserine O-trans-acetylase NT05HA_0901 ENOG4105ETE Transcriptional regulator (LacI family NT05HA_0902 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) NT05HA_0903 ENOG4105XW2 UPF0263 protein NT05HA_0904 ENOG4105CQ0 ABC transporter NT05HA_0906 ENOG4107QI1 Mate efflux family protein NT05HA_0907 ENOG4108R6K riboflavin synthase, subunit alpha NT05HA_0908 ENOG4105HBR Rna-binding protein NT05HA_0909 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) NT05HA_0910 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase NT05HA_0911 ENOG4105EUJ GTP cyclohydrolase i NT05HA_0912 ENOG4105CVM Molybdenum cofactor synthesis domain protein NT05HA_0913 ENOG4105D06 uba thif-type nad fad binding protein NT05HA_0914 ENOG4107W52 maltose operon periplasmic protein NT05HA_0915 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) NT05HA_0917 ENOG4108IJ9 (ABC) transporter NT05HA_0918 ENOG4107FKK extracellular solute-binding protein family 1 NT05HA_0919 ENOG4107FKK extracellular solute-binding protein family 1 NT05HA_0920 ENOG4105D56 permease protein NT05HA_0921 ENOG4105EG2 ABC transporter, permease NT05HA_0922 ENOG4107T9C Alpha amylase catalytic region NT05HA_0940 ENOG41061ZR Transcriptional regulator NT05HA_0941 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) NT05HA_0942 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) NT05HA_0943 ENOG4108IUK alpha amylase, catalytic NT05HA_0944 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NT05HA_0945 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase NT05HA_0946 ENOG4105E96 Colicin v production protein NT05HA_0947 ENOG4105PQ6 UPF0208 membrane protein NT05HA_0948 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) NT05HA_0949 ENOG4108DNC Involved in acetate metabolism (By similarity) NT05HA_0951 ENOG4105CXY transporter NT05HA_0952 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase NT05HA_0953 ENOG4105DJ0 Poly(A) Polymerase NT05HA_0955 ENOG4105SVQ Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression (By similarity) NT05HA_0957 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 NT05HA_0958 ENOG4105BZ1 (ABC) transporter NT05HA_0959 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) NT05HA_0960 ENOG41085JB UPF0434 protein NT05HA_0962 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) NT05HA_0963 ENOG4105K3M )-transporter NT05HA_0964 ENOG4106NDP Transcriptional regulator NT05HA_0966 ENOG4105CNT hydrolase family 2 NT05HA_0968 ENOG4105F38 ABC transporter, permease NT05HA_0970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_0972 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) NT05HA_0973 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) NT05HA_0976 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) NT05HA_0977 ENOG4105D7K pfkb domain protein NT05HA_0981 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) NT05HA_0983 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) NT05HA_0984 ENOG4105CHV Transcription elongation factor NusA NT05HA_0985 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) NT05HA_0989 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) NT05HA_0991 ENOG4108BY2 phosphohistidine phosphatase NT05HA_0992 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) NT05HA_0993 ENOG4105EEI dihydropteroate synthase NT05HA_0994 ENOG4106KPZ rard protein NT05HA_0995 ENOG4105FKN transcriptional regulator, AsnC family NT05HA_0996 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) NT05HA_1001 ENOG4105DQ6 Transposase NT05HA_1002 ENOG4107TT5 NLP P60 protein NT05HA_1003 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase NT05HA_1004 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) NT05HA_1006 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) NT05HA_1007 ENOG4108XTF Outer Membrane Lipoprotein NT05HA_1008 ENOG4105NBI YecM protein NT05HA_1011 ENOG4106J39 exported protein NT05HA_1012 ENOG4105CFG Acts as a chaperone (By similarity) NT05HA_1013 ENOG4108R4U Hnh endonuclease NT05HA_1014 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) NT05HA_1016 ENOG4105C28 cystathionine NT05HA_1017 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase NT05HA_1021 ENOG4105CDU Replicative dna helicase NT05HA_1034 ENOG4108UUM single-stranded DNA-binding protein NT05HA_1041 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NT05HA_1044 ENOG4105E18 UPF0276 protein NT05HA_1046 ENOG4109045 doxx family NT05HA_1056 ENOG4105CA0 peroxidase NT05HA_1057 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) NT05HA_1058 ENOG4105CEY Amp-dependent synthetase and ligase NT05HA_1059 ENOG4105R8X Outer membrane lipoprotein Slp NT05HA_1060 ENOG41072GX Peptidase M22 Glycoprotease NT05HA_1061 ENOG4105DVT helicase NT05HA_1062 ENOG4105DSB aldose 1-epimerase NT05HA_1064 ENOG4105E90 ABC transporter NT05HA_1065 ENOG4108IJ8 ABC transporter NT05HA_1067 ENOG4107QR8 Thioredoxin NT05HA_1068 ENOG4105C3M thioredoxin reductase NT05HA_1071 ENOG4108JJ8 (ABC) transporter NT05HA_1072 ENOG4105C29 acyl-CoA thioesterase NT05HA_1074 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase NT05HA_1076 ENOG4105F3T (LipO)protein NT05HA_1077 ENOG4108RJ9 Glycosyl transferase, family 2 NT05HA_1079 ENOG41068D6 Glycosyltransferase NT05HA_1081 ENOG4108ZPC Polysaccharide pyruvyl transferase NT05HA_1082 ENOG41080C8 DUF218 domain NT05HA_1086 ENOG4105C4R Atp-dependent dna helicase NT05HA_1087 ENOG4105C6Z Gluconate NT05HA_1088 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family NT05HA_1090 ENOG4105DIQ Transcriptional regulator NT05HA_1091 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) NT05HA_1094 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein NT05HA_1095 ENOG4108MG3 formate dehydrogenase NT05HA_1096 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) NT05HA_1097 ENOG4105E0C molybdate abc transporter NT05HA_1098 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein NT05HA_1099 ENOG4105F4R Transcriptional regulator mode NT05HA_1100 ENOG4105DK2 UPF0207 protein NT05HA_1101 ENOG4105C0H protease NT05HA_1102 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) NT05HA_1103 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) NT05HA_1104 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) NT05HA_1105 ENOG4105ETT transcriptional Regulator, LysR family NT05HA_1108 ENOG4105CM2 brancheD-chain amino acid aminotransferase NT05HA_1110 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) NT05HA_1111 ENOG4105ECP epimerase NT05HA_1113 ENOG4105DGN Electron transport complex NT05HA_1114 ENOG4108R3D Electron transport complex NT05HA_1115 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) NT05HA_1118 ENOG4105DZB Electron transport complex NT05HA_1119 ENOG4105CSM endonuclease III NT05HA_1122 ENOG4108IUS Transketolase NT05HA_1128 ENOG4105C5H ABC transporter NT05HA_1129 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein NT05HA_1130 ENOG41067MG lrgb family NT05HA_1131 ENOG4105VAW lrga family NT05HA_1133 ENOG4105CUC YeeE YedE family protein NT05HA_1135 ENOG4105KK6 nuclease NT05HA_1136 ENOG4105C9B Cysteine desulfurase NT05HA_1137 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) NT05HA_1138 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) NT05HA_1139 ENOG4105D1S lipid A biosynthesis NT05HA_1140 ENOG4107XHZ cytoplasmic chaperone TorD family protein NT05HA_1141 ENOG4105DYS nad(p)h dehydrogenase (quinone) NT05HA_1143 ENOG4107QX8 SPFH domain, Band 7 family protein NT05HA_1144 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic NT05HA_1145 ENOG4108MVK Receptor NT05HA_1147 ENOG4105DHS permease protein NT05HA_1148 ENOG4105CM4 permease protein NT05HA_1149 ENOG4108IPW abc transporter atp-binding protein NT05HA_1150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) NT05HA_1151 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) NT05HA_1153 ENOG4108MG9 hydrogenase 3 maturation protease NT05HA_1154 ENOG4105I6X formate hydrogenlyase maturation NT05HA_1155 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit NT05HA_1157 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) NT05HA_1158 ENOG4108JPZ Monovalent cation H antiporter subunit D NT05HA_1159 ENOG4107WQX hydrogenase 4 membrane subunit NT05HA_1160 ENOG4105D65 subunit l NT05HA_1161 ENOG4107TDF Formate hydrogenlyase subunit 4 NT05HA_1162 ENOG4108JPZ Monovalent cation H antiporter subunit D NT05HA_1163 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) NT05HA_1164 ENOG4105C8H hydrogenase maturation protein Hypf NT05HA_1165 ENOG4105F9E Shikimate 5-dehydrogenase NT05HA_1166 ENOG41075D4 Aminoglycoside 6-adenylyltransferase NT05HA_1169 ENOG4105C45 hydrogenase expression formation protein (HypE) NT05HA_1170 ENOG4105CQS hydrogenase expression formation protein HypD NT05HA_1171 ENOG4107RSS Hydrogenase accessory protein HypB NT05HA_1172 ENOG4108JJB ABC transporter NT05HA_1174 ENOG4107XQ1 cobalamin (vitamin B12) biosynthesis CbiM protein NT05HA_1175 ENOG4108A51 NT05HA_1176 ENOG4105UZ0 ABC-type Co2 transport system, periplasmic component NT05HA_1177 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) NT05HA_1179 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) NT05HA_1180 ENOG4105T95 Thiol disulfide interChange protein NT05HA_1186 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) NT05HA_1187 ENOG4108QD1 Membrane NT05HA_1188 ENOG4105F27 Major Facilitator NT05HA_1192 ENOG4105C4Y ABC transporter NT05HA_1194 ENOG4105C4Y ABC transporter NT05HA_1195 ENOG4107RCV ABC transporter, permease NT05HA_1196 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_1198 ENOG4105ECY inositol monophosphatase NT05HA_1199 ENOG4105CVS RNA methyltransferase TrmH family, group 1 NT05HA_1200 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family NT05HA_1202 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins NT05HA_1203 ENOG4108Z4V iron-sulfur cluster assembly NT05HA_1204 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) NT05HA_1205 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB NT05HA_1206 ENOG4108ZIT Ferredoxin, 2FE-2S NT05HA_1207 ENOG4105WVQ Fe-S assembly protein IscX NT05HA_1208 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) NT05HA_1209 ENOG4105D1F ATP-binding protein NT05HA_1210 ENOG41065CD Exported protein NT05HA_1211 ENOG4105D7X high-affinity nickel-transporter NT05HA_1215 ENOG4105C0H protease NT05HA_1216 ENOG4105C5H ABC transporter NT05HA_1219 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT05HA_1220 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT05HA_1223 ENOG4108RMU ferritin dps family protein NT05HA_1224 ENOG4105CW7 secretion protein, HlyD family NT05HA_1225 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT05HA_1226 ENOG4105C4Y ABC transporter NT05HA_1228 ENOG4105CAF HipA N-terminal domain protein NT05HA_1232 ENOG4105MYG DNA polymerase iii, chi subunit NT05HA_1233 ENOG4105C9Q fumarate hydratase class II NT05HA_1234 ENOG4105RHG NT05HA_1235 ENOG4105D0Y UPF0227 protein NT05HA_1236 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) NT05HA_1237 ENOG4108DBC nitroreductase NT05HA_1238 ENOG41090BQ Glutaredoxin NT05HA_1240 ENOG4105CNT hydrolase family 2 NT05HA_1241 ENOG4105E0U tyrosine-specific transport protein NT05HA_1243 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase NT05HA_1244 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase NT05HA_1245 ENOG4105DW5 Transcriptional regulator NT05HA_1248 ENOG4106ETB IIa component NT05HA_1253 ENOG41090HJ UPF0265 protein NT05HA_1254 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) NT05HA_1255 ENOG4105CIH Imidazole acetol-phosphate transaminase NT05HA_1256 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase NT05HA_1257 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) NT05HA_1258 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) NT05HA_1259 ENOG4105F0Z galactose-1-phosphate uridylyltransferase NT05HA_1260 ENOG41060NJ transcriptional regulator NT05HA_1261 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator NT05HA_1263 ENOG4108HWV )-transporter NT05HA_1265 ENOG4105BZU Histidine kinase NT05HA_1266 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NT05HA_1267 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) NT05HA_1268 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) NT05HA_1271 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ NT05HA_1272 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) NT05HA_1273 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) NT05HA_1276 ENOG4107835 probably involved in intracellular septation (By similarity) NT05HA_1277 ENOG4105NAU thioesterase Superfamily protein NT05HA_1278 ENOG4105K9H YciI-like protein NT05HA_1279 ENOG4107SC1 transglycosylase NT05HA_1280 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) NT05HA_1281 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase NT05HA_1282 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) NT05HA_1285 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) NT05HA_1289 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NT05HA_1290 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) NT05HA_1291 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) NT05HA_1293 ENOG4105DIN metallophosphoesterase NT05HA_1294 ENOG4108HUF Transporter NT05HA_1295 ENOG4105DQ5 transport system permease protein NT05HA_1296 ENOG4108IHU transport system permease protein NT05HA_1297 ENOG4105E0A ABC, transporter NT05HA_1298 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) NT05HA_1299 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) NT05HA_1300 ENOG4105E33 succinate dehydrogenase NT05HA_1301 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) NT05HA_1302 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) NT05HA_1303 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) NT05HA_1304 ENOG4105CIH Imidazole acetol-phosphate transaminase NT05HA_1305 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) NT05HA_1306 ENOG4105NSG hemerythrin hhe cation binding domain protein NT05HA_1308 ENOG4105VIE preprotein translocase, subunit YajC NT05HA_1309 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NT05HA_1310 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NT05HA_1311 ENOG4107ENK receptor NT05HA_1312 ENOG4108EKI Dehydrogenase NT05HA_1313 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) NT05HA_1314 ENOG4105C26 Dehydrogenase NT05HA_1315 ENOG4105CXY transporter NT05HA_1316 ENOG4105ECY inositol monophosphatase NT05HA_1317 ENOG4105DH8 myo-inositol catabolism NT05HA_1318 ENOG4106KNT transcriptional regulator NT05HA_1319 ENOG4105D7K pfkb domain protein NT05HA_1320 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) NT05HA_1321 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) NT05HA_1322 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) NT05HA_1328 ENOG4105C12 Phosphoribosylglycinamide synthetase NT05HA_1329 ENOG4105DC1 bifunctional purine biosynthesis protein purh NT05HA_1330 ENOG4105C5Y PTS System NT05HA_1331 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) NT05HA_1332 ENOG4108WPU DNA polymerase III subunit psi NT05HA_1333 ENOG4105KEG ribosomal-protein-alanine acetyltransferase NT05HA_1334 ENOG4105DSY exodeoxyribonuclease V, gamma NT05HA_1342 ENOG4105KCK Peptidoglycan-associated lipoprotein NT05HA_1343 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) NT05HA_1347 ENOG4105E02 MotA TolQ exbB proton channel NT05HA_1348 ENOG4107YD3 Thioesterase NT05HA_1349 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii NT05HA_1350 ENOG4105C4M (Ubiquinol oxidase) subunit I NT05HA_1353 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) NT05HA_1357 ENOG4108TIT dATP pyrophosphohydrolase NT05HA_1360 ENOG4105C9M aspartyl-trna synthetase NT05HA_1363 ENOG4105CXY transporter NT05HA_1365 ENOG4107ENK receptor NT05HA_1366 ENOG4108UYE Lactoylglutathione lyase NT05HA_1367 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) NT05HA_1368 ENOG4105D3Y Na H antiporter NT05HA_1372 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family NT05HA_1373 ENOG4105WPN DNA integration recombination invertion protein NT05HA_1375 ENOG4105EAH synthase NT05HA_1378 ENOG4105QYV Membrane NT05HA_1379 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control NT05HA_1381 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) NT05HA_1382 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) NT05HA_1383 ENOG4108J59 Extracellular solute-binding protein, family 5 NT05HA_1384 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NT05HA_1385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NT05HA_1386 ENOG4105C3U ABC transporter NT05HA_1387 ENOG4108JQ7 (ABC) transporter NT05HA_1388 ENOG41065U4 response regulator NT05HA_1389 ENOG4105YK5 50S ribosomal protein L36 NT05HA_1390 ENOG4105NRA 50s ribosomal protein l31 type b NT05HA_1392 ENOG4108URH decarboxylase NT05HA_1394 ENOG4105MGM doxx family NT05HA_1396 ENOG4105C03 ribonuclease NT05HA_1397 ENOG4105EI2 Pseudouridine synthase NT05HA_1398 ENOG4105K63 Thioredoxin NT05HA_1399 ENOG4105C5I Dehydrogenase NT05HA_1400 ENOG4105C28 cystathionine NT05HA_1404 ENOG4105CFH Aspartokinase NT05HA_1405 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) NT05HA_1408 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 NT05HA_1409 ENOG4105DFU Cell wall formation (By similarity) NT05HA_1412 ENOG4105CA3 membrane-bound lytic murein transglycosylase NT05HA_1413 ENOG4105CUZ uba thif-type nad fad binding protein NT05HA_1414 ENOG4105NXV High-affinity zinc uptake system protein NT05HA_1415 ENOG4105CKD glutathione-regulated potassium-efflux system protein NT05HA_1416 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family NT05HA_1421 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) NT05HA_1422 ENOG4105VDB UPF0125 protein NT05HA_1423 ENOG4108Z1B Cyclase dehydrase NT05HA_1425 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase NT05HA_1426 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) NT05HA_1427 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) NT05HA_1428 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NT05HA_1429 ENOG4105CB5 ATP-dependent DNA helicase recG NT05HA_1430 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) NT05HA_1431 ENOG4105EZE Cupin 4 family protein NT05HA_1432 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) NT05HA_1433 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) NT05HA_1434 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN NT05HA_1435 ENOG4108IUZ ABC transporter NT05HA_1436 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA NT05HA_1437 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) NT05HA_1438 ENOG4105DHJ ABC, transporter NT05HA_1439 ENOG4105CY3 ABC transporter, permease NT05HA_1440 ENOG4107PE3 Mammalian cell entry related domain protein NT05HA_1441 ENOG4105E3I toluene tolerance NT05HA_1443 ENOG4105VFK BolA family NT05HA_1444 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) NT05HA_1445 ENOG4105N42 UPF0307 protein NT05HA_1446 ENOG4105CMS peptidase U62, modulator of DNA gyrase NT05HA_1447 ENOG4108UGV hypoxanthine phosphoribosyltransferase NT05HA_1448 ENOG4105BZW Glycerate kinase NT05HA_1449 ENOG4107QQ0 gntp family NT05HA_1450 ENOG4107VHA regulatoR NT05HA_1455 ENOG4105BZ1 (ABC) transporter NT05HA_1458 ENOG4105C1J atp-dependent rna helicase NT05HA_1459 ENOG4105RT1 May be involved in cell division (By similarity) NT05HA_1461 ENOG4108R66 Conserved Protein NT05HA_1462 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase NT05HA_1465 ENOG4107QHF type ii secretion system protein e NT05HA_1466 ENOG4105D7Q type ii secretion system NT05HA_1469 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) NT05HA_1471 ENOG4105BZG amino acid carrier protein NT05HA_1475 ENOG4105DSQ Nitric oxide reductase NT05HA_1480 ENOG4108ETH Formylglycinamide ribotide synthetase NT05HA_1481 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) NT05HA_1482 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NT05HA_1484 ENOG4108IA2 Sodium pantothenate symporter NT05HA_1485 ENOG4105RG0 Membrane NT05HA_1487 ENOG4105EYA deoxyribonuclease NT05HA_1488 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) NT05HA_1490 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) NT05HA_1495 ENOG4105K6T rare lipoprotein A NT05HA_1496 ENOG4105CNI cell division protein FtsW NT05HA_1497 ENOG4105CJN penicillin-binding protein NT05HA_1499 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) NT05HA_1500 ENOG4105C1J atp-dependent rna helicase NT05HA_1501 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) NT05HA_1502 ENOG4107RGD Major Facilitator superfamily NT05HA_1504 ENOG4105CHR reductase NT05HA_1505 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase NT05HA_1507 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) NT05HA_1508 ENOG4105VGS 50s ribosomal protein l32 NT05HA_1509 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein NT05HA_1510 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) NT05HA_1511 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT05HA_1512 ENOG4105HSA Protein of unknown function (DUF452) NT05HA_1513 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) NT05HA_1514 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) NT05HA_1515 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) NT05HA_1517 ENOG41077RS Phosphatase NT05HA_1518 ENOG4105E8V Alpha Beta Hydrolase Fold protein NT05HA_1519 ENOG4105DJ4 phosphatidylserine decarboxylase NT05HA_1520 ENOG4108V1T peptidylprolyl cis-trans isomerase NT05HA_1521 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) NT05HA_1522 ENOG4105DWK Membrane NT05HA_1523 ENOG4107XM3 UPF0442 protein NT05HA_1524 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) NT05HA_1525 ENOG4105C37 (CBS) domain NT05HA_1526 ENOG4105RX8 Protein of unknown function (DUF1523) NT05HA_1527 ENOG4105F8V Hydrolase, tatD family NT05HA_1528 ENOG4107QRG dna polymerase iii NT05HA_1529 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) NT05HA_1530 ENOG4105HHA aminodeoxychorismate lyase NT05HA_1531 ENOG4105HHA aminodeoxychorismate lyase NT05HA_1532 ENOG4105DSF transport protein NT05HA_1533 ENOG4108YZA Nitrogen regulatory protein pii NT05HA_1535 ENOG4108K4B hydrolase NT05HA_1542 ENOG4108RIR Molybdenum cofactor biosynthesis protein NT05HA_1543 ENOG4108HPI phosphatidate Cytidylyltransferase NT05HA_1545 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase NT05HA_1546 ENOG4107QWE )-transporter NT05HA_1548 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NT05HA_1549 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NT05HA_1550 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) NT05HA_1551 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) NT05HA_1553 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NT05HA_1554 ENOG4105DZP Membrane-associated zinc metalloprotease NT05HA_1555 ENOG4105KNE Phosphatidate cytidylyltransferase NT05HA_1556 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) NT05HA_1559 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) NT05HA_1561 ENOG4105D0C transport protein NT05HA_1562 ENOG4105CQ0 ABC transporter NT05HA_1566 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) NT05HA_1567 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) NT05HA_1569 ENOG4105DMQ Methyltransferase NT05HA_1570 ENOG4105CIC tryptophan-specific transport protein NT05HA_1571 ENOG4105F0N pyrophosphate phospho-hydrolase NT05HA_1572 ENOG4105ERG peptidase m48, ste24p NT05HA_1573 ENOG41067XB TonB family NT05HA_1574 ENOG4105M15 transport protein ExbD NT05HA_1575 ENOG4105M8K biopolymer transport protein NT05HA_1576 ENOG4108JU6 CBS domain protein NT05HA_1577 ENOG4106KVJ cytochrome C assembly protein NT05HA_1578 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY NT05HA_1579 ENOG41079J1 NT05HA_1580 ENOG4105E55 glycerol-3-phosphate acyltransferase NT05HA_1581 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) NT05HA_1582 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) NT05HA_1583 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) NT05HA_1585 ENOG4105K9Q Binds to the 23S rRNA (By similarity) NT05HA_1586 ENOG4105C79 DNA protecting protein DprA NT05HA_1587 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) NT05HA_1588 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) NT05HA_1591 ENOG4105BZM domain protein NT05HA_1592 ENOG4108RRZ Transcription elongation factor GreB NT05HA_1594 ENOG4108WQI RNA Polymerase NT05HA_1596 ENOG4105EX9 Membrane NT05HA_1597 ENOG410601J HemY protein NT05HA_1598 ENOG4105ECF c-methyltransferase NT05HA_1599 ENOG41076E6 Uroporphyrinogen-III Synthase NT05HA_1600 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) NT05HA_1601 ENOG4107T0K Adenylate cyclase NT05HA_1602 ENOG4105WH1 Two component transcriptional regulator luxr family NT05HA_1603 ENOG4105CFU surface antigen NT05HA_1604 ENOG4105MA0 exported protein NT05HA_1605 ENOG4105C9X ppx gppa phosphatase NT05HA_1610 ENOG4105CJ2 (LipO)protein NT05HA_1612 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) NT05HA_1613 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) NT05HA_1614 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) NT05HA_1615 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) NT05HA_1618 ENOG4105M85 Bola protein NT05HA_1619 ENOG4105IEY (LipO)protein NT05HA_1623 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division NT05HA_1624 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) NT05HA_1625 ENOG4105CEN a g-specific adenine glycosylase NT05HA_1629 ENOG41090ED Protein with unknown function (DUF469) NT05HA_1630 ENOG4105BZ1 (ABC) transporter NT05HA_1631 ENOG4105BZ1 (ABC) transporter NT05HA_1632 ENOG4105E7U AraC family transcriptional regulator NT05HA_1634 ENOG4105DKP glycosyl transferase, family 9 NT05HA_1637 ENOG41075W9 High frequency lysogenization protein HflD homolog NT05HA_1638 ENOG4107QTF adenylosuccinate lyase NT05HA_1640 ENOG4107QKW extracellular solute-binding protein family 1 NT05HA_1644 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component NT05HA_1645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_1646 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) NT05HA_1647 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) NT05HA_1648 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) NT05HA_1649 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) NT05HA_1650 ENOG4105DSJ YicC domain protein NT05HA_1651 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) NT05HA_1655 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) NT05HA_1656 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) NT05HA_1657 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) NT05HA_1658 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NT05HA_1659 ENOG41080IJ Diacylglycerol kinase NT05HA_1663 ENOG4105CRP Part of the ABC transporter FtsEX involved in NT05HA_1664 ENOG4105CAK Cell division ATP-binding protein ftsE NT05HA_1665 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) NT05HA_1666 ENOG4106H78 methyltransferase NT05HA_1667 ENOG4108EQA pts system NT05HA_1668 ENOG4105ETZ PTS System NT05HA_1669 ENOG4105F3R pts system mannose fructose sorbose family iid NT05HA_1670 ENOG410667J hydrolase NT05HA_1672 ENOG4105CXY transporter NT05HA_1673 ENOG4105E0A ABC, transporter NT05HA_1674 ENOG4105EHG Permease protein NT05HA_1675 ENOG4105S10 periplasmic binding protein NT05HA_1676 ENOG4106ZKY NT05HA_1677 ENOG4107RNH Outer membrane receptor FepA NT05HA_1679 ENOG4105CND Glycosyl transferase, family 2 NT05HA_1680 ENOG4107BJW polysaccharide deacetylase NT05HA_1682 ENOG4105D3A purine nucleoside phosphorylase DeoD-type NT05HA_1683 ENOG4105D9N nucleoside NT05HA_1684 ENOG4105M5K heptosyltransferase NT05HA_1685 ENOG4108IJ0 Aspartate ammonia-lyase NT05HA_1686 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 NT05HA_1687 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) NT05HA_1688 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) NT05HA_1689 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) NT05HA_1692 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) NT05HA_1694 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) NT05HA_1695 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NT05HA_1696 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant NT05HA_1701 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) NT05HA_1715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NT05HA_1717 ENOG4105C2D reductase NT05HA_1718 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NT05HA_1719 ENOG4105JIM Phosphatidylserine synthase NT05HA_1720 ENOG4105EIB trna rrna methyltransferase NT05HA_1722 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding NT05HA_1723 ENOG41083KI ribonuclease, T2 NT05HA_1725 ENOG4105D2N Aldolase NT05HA_1726 ENOG4105PF3 O-Antigen polymerase NT05HA_1727 ENOG4108EUD Lysophospholipase NT05HA_1728 ENOG4107Z6W Protein CrcB homolog NT05HA_1729 ENOG4105DQF Hydrolase NT05HA_1735 ENOG4105C7B Threonine dehydratase NT05HA_1737 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NT05HA_1740 ENOG4105CJ1 ABC, transporter NT05HA_1741 ENOG4108KYE ABC-2 type transporter NT05HA_1750 ENOG4108RR8 protoporphyrinogen oxidase NT05HA_1752 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) NT05HA_1754 ENOG4105W0Z cytoplasmic protein NT05HA_1755 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase NT05HA_1756 ENOG4108VVQ metallophosphoesterase NT05HA_1757 ENOG4105E0U tyrosine-specific transport protein NT05HA_1759 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein NT05HA_1760 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NT05HA_1762 ENOG4105CXB phosphoribosylaminoimidazole synthetase NT05HA_1763 ENOG4108V3E phosphoribosylglycinamide formyltransferase NT05HA_1764 ENOG4108X4Q Hydrolase NT05HA_1765 ENOG4105MJ2 Competence protein NT05HA_1767 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase NT05HA_1768 ENOG41064N2 Protein of unknown function (DUF2726) NT05HA_1769 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) NT05HA_1772 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) NT05HA_1774 ENOG4105ECC imidazole-glycerol-phosphate dehydratase NT05HA_1775 ENOG4105CIH Imidazole acetol-phosphate transaminase NT05HA_1776 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) NT05HA_1777 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) NT05HA_1778 ENOG4105CWM branched-chain amino acid transport system II carrier protein NT05HA_1779 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) NT05HA_1780 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) NT05HA_1782 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) NT05HA_1783 ENOG4108UJU UPF0301 protein NT05HA_1784 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) NT05HA_1785 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) NT05HA_1786 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NT05HA_1789 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) NT05HA_1790 ENOG4108M6U Universal stress protein A NT05HA_1791 ENOG4105DXN mazG family NT05HA_1793 ENOG4105E68 Sulfatase NT05HA_1794 ENOG4105YDX UPF0352 protein NT05HA_1796 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) NT05HA_1797 ENOG4105E3W Two component transcriptional regulator (Winged helix family NT05HA_1798 ENOG4105E0F Histidine kinase NT05HA_1799 ENOG4105D6U Sodium Glutamate Symporter NT05HA_1801 ENOG4107S2Z UPF0761 membrane protein NT05HA_1802 ENOG4105K5B UPF0225 protein NT05HA_1804 ENOG4105D7A ATP-binding protein NT05HA_1806 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) NT05HA_1807 ENOG410804X Transcriptional regulator NT05HA_1808 ENOG4105K70 DNA-binding protein NT05HA_1809 ENOG4105R2J Conserved Protein NT05HA_1810 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) NT05HA_1812 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) NT05HA_1813 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) NT05HA_1814 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) NT05HA_1815 ENOG4108VZM 50s ribosomal protein L10 NT05HA_1818 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) NT05HA_1819 ENOG4105PM1 preprotein translocase subunit SecE NT05HA_1820 ENOG4108WC9 type VI secretion system effector, hcp1 family NT05HA_1822 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system NT05HA_1838 ENOG4105DFP Integrase NT05HA_1841 ENOG4107R3N Filamentation induced by cAMP protein fic NT05HA_1845 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) NT05HA_1846 ENOG4105C1J atp-dependent rna helicase NT05HA_1847 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) NT05HA_1849 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) NT05HA_1850 ENOG4105D3G Pseudouridine synthase NT05HA_1865 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) NT05HA_1873 ENOG4105DM4 PTS System NT05HA_1874 ENOG4105DE4 1-phosphofructokinase NT05HA_1875 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein NT05HA_1877 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) NT05HA_1879 ENOG4108Z33 Thiol disulfide Interchange Protein NT05HA_1880 ENOG4108WFC UPF0438 protein yifE NT05HA_1881 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) NT05HA_1882 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) NT05HA_1894 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) NT05HA_1895 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate NT05HA_1896 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) NT05HA_1897 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) NT05HA_1901 ENOG4106032 Glutathionylspermidine synthase NT05HA_1903 ENOG4105C2M dna polymerase I NT05HA_1906 ENOG4105C4R Atp-dependent dna helicase NT05HA_1911 ENOG4107VXZ Hydrolase NT05HA_1912 ENOG4108UW5 maltose o-acetyltransferase NT05HA_1913 ENOG4105W39 Membrane NT05HA_1915 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR NT05HA_1920 ENOG4107FB0 transcriptional regulator DeoR family NT05HA_1921 ENOG4105C0P Mg chelatase subunit ChlI NT05HA_1929 ENOG4105PXI polysaccharide deacetylase NT05HA_1930 ENOG41063SB peptidase NT05HA_1932 ENOG4105CKW Inner membrane protein yedI NT05HA_1936 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NT05HA_1937 ENOG4105CV1 Transketolase (EC 2.2.1.1) NT05HA_1939 ENOG4105KME endoribonuclease L-psp NT05HA_1941 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) NT05HA_1942 ENOG4105C5H ABC transporter NT05HA_1943 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein NT05HA_1947 ENOG4105C31 Tryptophanyl-tRNA synthetase NT05HA_1948 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) NT05HA_1949 ENOG4105DJV ribulose-phosphate 3-epimerase NT05HA_1950 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) NT05HA_1951 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) NT05HA_1952 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) NT05HA_1953 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) NT05HA_1954 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) NT05HA_1955 ENOG4108UM1 dedA family NT05HA_1957 ENOG4108K5P (LipO)protein NT05HA_1962 ENOG4105C0R drug resistance transporter emrb qaca subfamily NT05HA_1963 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b NT05HA_1964 ENOG4105WMJ Positive regulator of sigma E, RseC MucC NT05HA_1965 ENOG4105VQK sigma E regulatory protein, MucB RseB NT05HA_1966 ENOG41069PW sigma-e factor negative regulatory protein NT05HA_1967 ENOG4105EMN RNA polymerase sigma factor NT05HA_1968 ENOG4105Y75 tpr repeat protein NT05HA_1969 ENOG410814C multidrug resistance protein NT05HA_1971 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) NT05HA_1972 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) NT05HA_1973 ENOG4105EM7 Selenocysteine-specific translation elongation factor NT05HA_1975 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NT05HA_1976 ENOG4105KT7 mgtC SapB transporter NT05HA_1977 ENOG4108R99 pseudouridine synthase NT05HA_1978 ENOG4105C8J )-transporter NT05HA_1980 ENOG4105BZ1 (ABC) transporter NT05HA_1981 ENOG4108JJ9 ABC, transporter NT05HA_1982 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter NT05HA_1983 ENOG4107YZP Rhodanese domain protein NT05HA_1984 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) NT05HA_1985 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase NT05HA_1986 ENOG4105D7W serine acetyltransferase NT05HA_1988 ENOG4105CBT Fructose-1,6-bisphosphatase NT05HA_1989 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) NT05HA_1990 ENOG4105QTB Flavodoxin NT05HA_1991 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) NT05HA_1992 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) NT05HA_1996 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) NT05HA_1997 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) NT05HA_1999 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) NT05HA_2001 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) NT05HA_2003 ENOG4105XA0 heptosyltransferase ii NT05HA_2005 ENOG4106W3N NT05HA_2006 ENOG4105CGH 5'-nucleotidase NT05HA_2007 ENOG4105EJ2 Transcriptional regulator NT05HA_2008 ENOG4105C5Q Transcriptional regulator NT05HA_2009 ENOG4105EHV domain protein NT05HA_2010 ENOG4106032 Glutathionylspermidine synthase NT05HA_2011 ENOG4105CUW cytochrome C-TYPE protein NT05HA_2012 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) NT05HA_2013 ENOG4105GXZ Ferredoxin-type protein NapH NT05HA_2014 ENOG4108BGM Quinol dehydrogenase periplasmic component NT05HA_2017 ENOG4105BZU Histidine kinase NT05HA_2018 ENOG4105D4A Cell wall formation (By similarity) NT05HA_2020 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein NT05HA_2021 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT05HA_2022 ENOG4105CIN aminoacyl-histidine dipeptidase NT05HA_2026 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) NT05HA_2027 ENOG4108R3E Dna-3-methyladenine glycosylase i NT05HA_2029 ENOG4105R3P Inner membrane protein yagU NT05HA_2030 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) NT05HA_2032 ENOG4105XQ6 frataxin-like protein NT05HA_2033 ENOG4105C9U ATP-dependent DNA helicase RecQ NT05HA_2034 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NT05HA_2035 ENOG4105CS9 pantothenic acid kinase NT05HA_2041 ENOG4105CDA abc transporter atp-binding protein NT05HA_2042 ENOG4105E5Q amino acid AbC transporter NT05HA_2043 ENOG4105EAB amino acid AbC transporter NT05HA_2044 ENOG4105CJP fad dependent oxidoreductase NT05HA_2045 ENOG41069P5 Protein slyX homolog NT05HA_2046 ENOG4108V1T peptidylprolyl cis-trans isomerase NT05HA_2047 ENOG4105WWK YheO domain protein NT05HA_2048 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) NT05HA_2049 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) NT05HA_2052 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor NT05HA_2053 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) NT05HA_2055 ENOG410689M (LipO)protein NT05HA_2060 ENOG4107RUE extracellular solute-binding protein family 1 NT05HA_2064 ENOG4105ECR NmrA family NT05HA_2065 ENOG4105KVH Transcriptional regulator NT05HA_2066 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit NT05HA_2068 ENOG41063VX Inherit from COG: glutaredoxin-related protein NT05HA_2069 ENOG4105D6F Phosphatase NT05HA_2072 ENOG4105C38 Glycyl-tRNA synthetase beta subunit NT05HA_2073 ENOG4105D52 delta-aminolevulinic acid dehydratase NT05HA_2074 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) NT05HA_2076 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) NT05HA_2079 ENOG4105JC1 sterol-binding domain protein NT05HA_2080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NT05HA_2082 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) NT05HA_2083 ENOG4105VEJ Heat shock protein NT05HA_2084 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 NT05HA_2085 ENOG4107RK2 ADP-ribose diphosphatase NudE NT05HA_2086 ENOG4105E7U AraC family transcriptional regulator NT05HA_2087 ENOG4108KBJ Inner membrane protein YkgB NT05HA_2088 ENOG4105EPD Oligopeptide transporter, Opt family NT05HA_2090 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase NT05HA_2091 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase NT05HA_2097 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) NT05HA_2098 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) NT05HA_2104 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein NT05HA_2105 ENOG410903C (LipO)protein NT05HA_2107 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) NT05HA_2108 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain NT05HA_2121 ENOG4105CS6 Rhs element vgr protein NT05HA_2123 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NT05HA_2124 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) NT05HA_2125 ENOG4108MJ5 VirK protein NT05HA_2126 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) NT05HA_2128 ENOG4105D01 (LipO)protein NT05HA_2130 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NT05HA_2131 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase NT05HA_2140 ENOG4105C1A potassium transporter peripheral membrane NT05HA_2141 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) NT05HA_2142 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) NT05HA_2144 ENOG4108YZY peptidylprolyl cis-trans isomerase NT05HA_2145 ENOG4105Z2P Protein of unknown function (DUF465) NT05HA_2146 ENOG4105KJF protein tyrosine phosphatase NT05HA_2147 ENOG4106YJS accessory processing protein NT05HA_2148 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) NT05HA_2151 ENOG4105K89 arsenate reductase NT05HA_2153 ENOG4108I5U Uridine phosphorylase NT05HA_2154 ENOG4108VVK transcriptional Regulator, AsnC NT05HA_2156 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NT05HA_2158 ENOG4105DBV ornithine carbamoyltransferase NT05HA_2159 ENOG4105C5B carbamate kinase NT05HA_2160 ENOG4105CSX c4-dicarboxylate anaerobic carrier NT05HA_2161 ENOG4108YXU transcriptional regulator AsnC family NT05HA_2164 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) NT05HA_2165 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) NT05HA_2167 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity NT05HA_2168 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) NT05HA_2169 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) NT05HA_2170 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) NT05HA_2171 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) NT05HA_2172 ENOG41083MP 50s ribosomal protein l29 NT05HA_2173 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal NT05HA_2176 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) NT05HA_2177 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits NT05HA_2179 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) NT05HA_2180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) NT05HA_2181 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) NT05HA_2182 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) NT05HA_2183 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) NT05HA_2184 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) NT05HA_2187 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) NT05HA_2188 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) NT05HA_2189 ENOG4108ZT0 50S ribosomal protein l17 NT05HA_2190 ENOG4106WTF Glycosyl transferase, family 2 NT05HA_2191 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase NT05HA_2192 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) NT05HA_2193 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) NT05HA_2194 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) NT05HA_2195 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) NT05HA_2196 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) NT05HA_2198 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) NT05HA_2201 ENOG4105DJF DNA polymerase III, delta' subunit NT05HA_2203 ENOG4105M6F mutator MutT protein NT05HA_2204 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving NT05HA_2207 ENOG4105W1Y Transcriptional regulator NT05HA_2208 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NT05HA_2209 ENOG4108UUM single-stranded DNA-binding protein NT05HA_2214 ENOG4105ENX hydrolase NT05HA_2215 ENOG4108M0I Transcriptional regulator NT05HA_2225 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b NT05HA_2226 ENOG4107YZP Rhodanese domain protein NT05HA_2228 ENOG4105DFE Dna adenine methylase NT05HA_2229 ENOG4105D49 3-dehydroquinate synthase NT05HA_2230 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) NT05HA_2231 ENOG4105E4G Type IV pilus NT05HA_2238 ENOG4105D6S protein involved in catabolism of external DNA NT05HA_2240 ENOG4105DC8 reductase NT05HA_2241 ENOG4107RYR Transcriptional regulator, Crp Fnr family NT05HA_2242 ENOG4105YP7 UPF0270 protein NT05HA_2243 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) NT05HA_2245 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase NT05HA_2248 ENOG4105W0E 50S ribosomal protein L33 NT05HA_2252 ENOG4105W1T Glycosyl Transferase NT05HA_2254 ENOG4105W1T Glycosyl Transferase NT05HA_2258 ENOG4108KN0 Choline kinase NT05HA_2260 ENOG4105C25 Primosomal protein n' NT05HA_2261 ENOG41063M6 Cell Division Protein NT05HA_2262 ENOG4105Y7M Transcriptional regulator, TetR family NT05HA_2263 ENOG410624X efflux transporter, rnd family, mfp subunit NT05HA_2264 ENOG4105BZS acriflavin resistance protein NT05HA_2265 ENOG4108BSC Methyltransferase NT05HA_2267 ENOG4107QUT magnesium and cobalt transport protein CorA NT05HA_2268 ENOG4108VIA integral membrane protein NT05HA_2269 ENOG4105VZ9 UPF0235 protein NT05HA_2271 ENOG4108RCM Nitroreductase NT05HA_2272 ENOG4105E0M Sulfatase NT05HA_2274 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase NT05HA_2275 ENOG4105C34 Pseudouridine synthase NT05HA_2276 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane NT05HA_2277 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase NT05HA_2278 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) NT05HA_2279 ENOG4105E07 UPF0149 protein NT05HA_2280 ENOG4107RAQ aminopeptidase NT05HA_2283 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family NT05HA_2287 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) NT05HA_2289 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) NT05HA_2290 ENOG4105DFF Rod shape-determining protein mreb NT05HA_2292 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) NT05HA_2293 ENOG4105C2N RNA methyltransferase TrmH family group 3 NT05HA_2295 ENOG4105CXY transporter NT05HA_2296 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase NT05HA_2297 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase NT05HA_2298 ENOG4105EMY transcriptional regulator NT05HA_2299 ENOG4105DTR rard protein NT05HA_2300 ENOG4105E2X shikimate dehydrogenase NT05HA_2301 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) NT05HA_2302 ENOG4108WI1 Dna topoisomerase NT05HA_2303 ENOG4105CGY Dna recombination protein NT05HA_2304 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) NT05HA_2306 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) NT05HA_2307 ENOG4105E98 transcriptional regulator DeoR family NT05HA_2311 ENOG4105DFP Integrase NT05HA_2312 ENOG4105DFP Integrase NT05HA_2322 ENOG4105DFP Integrase NT05HA_2324 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NT05HA_2325 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) NT05HA_2326 ENOG4105VCC 30S ribosomal protein S21 NT05HA_2328 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) NT05HA_2330 ENOG4107104 thymidine kinase NT05HA_2332 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) NT05HA_2334 ENOG4105C6T cysteine synthase NT05HA_2336 ENOG4108RG0 uracil-dna glycosylase NT05HA_2337 ENOG4105C3G gtp-binding protein NT05HA_2338 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) NT05HA_2339 ENOG4108VPT UPF0234 protein NT05HA_2340 ENOG4108VPT UPF0234 protein NT05HA_2341 ENOG4105EAC phosphoserine phosphatase NT05HA_2342 ENOG41062Z9 Membrane NT05HA_2344 ENOG4105CJR Integral membrane protein (MviN NT05HA_2345 ENOG4105DTN riboflavin biosynthesis protein ribF NT05HA_2350 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein NT05HA_2351 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) NT05HA_2352 ENOG4105K8R UPF0145 protein NT05HA_2353 ENOG4105CSA Coproporphyrinogen iii oxidase NT05HA_2354 ENOG4105E66 phosphoriboisomerase A NT05HA_2355 ENOG4108JQ1 Dehydrogenase NT05HA_2356 ENOG4105CGZ zinc metallopeptidase NT05HA_2357 ENOG4108WZM domain protein NT05HA_2358 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) NT05HA_2359 ENOG4107ZVW dihydroneopterin aldolase NT05HA_2360 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) NT05HA_2362 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) NT05HA_2363 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) NT05HA_2364 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) NT05HA_2365 ENOG4105CHM Aminotransferase NT05HA_2366 ENOG4105E4F Isochorismate synthase NT05HA_2367 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) NT05HA_2368 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) NT05HA_2369 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) NT05HA_2370 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP NT05HA_2371 ENOG4105GPY SprT protein NT05HA_2373 ENOG4105C44 Serine transporter NT05HA_2374 ENOG4105EJQ L-serine dehydratase