locus-tag	class	description
NT05HA_0004	COG0252	asparaginase activity
NT05HA_0008	COG3063	Type IV pilus biogenesis stability protein PilW
NT05HA_0009	COG1426	Protein conserved in bacteria
NT05HA_0012	COG2976	Protein conserved in bacteria
NT05HA_0014	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NT05HA_0015	COG2233	PERMEase
NT05HA_0017	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NT05HA_0018	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NT05HA_0020	COG0659	secondary active sulfate transmembrane transporter activity
NT05HA_0021	COG0800	Aldolase
NT05HA_0023	COG0281	malic enzyme
NT05HA_0023	COG0280	phosphate acetyltransferase
NT05HA_0025	COG2814	Major facilitator Superfamily
NT05HA_0026	COG4133	protoheme IX ABC transporter activity
NT05HA_0027	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NT05HA_0028	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NT05HA_0029	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NT05HA_0031	COG1138	Cytochrome C-type biogenesis protein
NT05HA_0032	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NT05HA_0038	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
NT05HA_0039	COG0437	4 iron, 4 sulfur cluster binding
NT05HA_0040	COG3301	Polysulphide reductase, NrfD
NT05HA_0041	COG1138	Cytochrome C-type biogenesis protein
NT05HA_0042	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NT05HA_0043	COG3088	subunit of a heme lyase
NT05HA_0043	COG4235	cytochrome complex assembly
NT05HA_0044	COG2081	HI0933 family
NT05HA_0045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NT05HA_0046	COG1305	Transglutaminase-like
NT05HA_0048	COG2608	mercury ion transmembrane transporter activity
NT05HA_0050	COG2226	methyltransferase
NT05HA_0052	COG0592	DNA-directed DNA polymerase activity
NT05HA_0055	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NT05HA_0062	COG0602	queuosine metabolic process
NT05HA_0064	COG1328	CTP reductase activity
NT05HA_0064	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NT05HA_0066	COG1022	Amp-dependent synthetase and ligase
NT05HA_0068	COG0587	DNA-directed DNA polymerase activity
NT05HA_0069	COG0121	glutamine amidotransferase
NT05HA_0070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NT05HA_0077	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NT05HA_0079	COG1278	Cold shock
NT05HA_0080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NT05HA_0081	COG0494	nUDIX hydrolase
NT05HA_0082	COG0730	response to heat
NT05HA_0084	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NT05HA_0085	COG0590	tRNA wobble adenosine to inosine editing
NT05HA_0086	COG3078	GTPase activator activity
NT05HA_0088	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NT05HA_0089	COG0456	acetyltransferase
NT05HA_0090	COG0149	triose-phosphate isomerase activity
NT05HA_0091	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NT05HA_0094	COG0511	ligase activity, forming carbon-carbon bonds
NT05HA_0095	COG0439	Biotin carboxylase
NT05HA_0099	COG0681	Belongs to the peptidase S26 family
NT05HA_0103	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NT05HA_0106	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NT05HA_0108	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NT05HA_0111	COG0537	adenosine 5'-monophosphoramidase activity
NT05HA_0112	COG2116	formate transmembrane transporter activity
NT05HA_0113	COG1882	Formate acetyltransferase
NT05HA_0115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NT05HA_0117	COG0697	spore germination
NT05HA_0119	COG0204	Acyl-transferase
NT05HA_0121	COG5413	integral membrane protein
NT05HA_0122	COG2964	Protein conserved in bacteria
NT05HA_0123	COG0814	amino acid
NT05HA_0124	COG3033	Beta-eliminating lyase
NT05HA_0126	COG1509	lysine 2,3-aminomutase activity
NT05HA_0127	COG3061	Opacity-associated protein A
NT05HA_0127	COG3266	domain, Protein
NT05HA_0132	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NT05HA_0133	COG2814	Major facilitator Superfamily
NT05HA_0134	COG4974	Belongs to the 'phage' integrase family
NT05HA_0135	COG0544	peptidyl-prolyl cis-trans isomerase activity
NT05HA_0136	COG0330	HflC and HflK could
NT05HA_0137	COG0330	HflC and HflK could
NT05HA_0139	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NT05HA_0148	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NT05HA_0149	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NT05HA_0155	COG0174	glutamine synthetase
NT05HA_0156	COG0861	Integral membrane protein TerC family
NT05HA_0158	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NT05HA_0159	COG2067	long-chain fatty acid transport protein
NT05HA_0160	COG2067	long-chain fatty acid transport protein
NT05HA_0161	COG3691	Protein conserved in bacteria
NT05HA_0162	COG0471	metal ion transport
NT05HA_0164	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NT05HA_0165	COG1575	Belongs to the MenA family. Type 1 subfamily
NT05HA_0166	COG1720	tRNA m6t6A37 methyltransferase activity
NT05HA_0167	COG0789	Transcriptional regulator
NT05HA_0168	COG2608	mercury ion transmembrane transporter activity
NT05HA_0170	COG2217	Heavy metal translocating P-type atpase
NT05HA_0171	COG3739	integral membrane protein
NT05HA_0173	COG0740	serine-type endopeptidase activity
NT05HA_0175	COG2194	sulfuric ester hydrolase activity
NT05HA_0176	COG2918	glutathione biosynthetic process
NT05HA_0176	COG1181	Belongs to the D-alanine--D-alanine ligase family
NT05HA_0186	COG4964	Belongs to the GSP D family
NT05HA_0191	COG1702	phosphate starvation-inducible protein PhoH
NT05HA_0192	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NT05HA_0194	COG1444	tRNA N-acetyltransferase activity
NT05HA_0196	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NT05HA_0201	COG1126	abc transporter atp-binding protein
NT05HA_0202	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT05HA_0203	COG4215	(ABC) transporter
NT05HA_0204	COG4160	amino acid transport
NT05HA_0205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT05HA_0206	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT05HA_0208	COG1966	Carbon starvation protein
NT05HA_0211	COG3116	cell division
NT05HA_0212	COG0768	penicillin binding
NT05HA_0213	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NT05HA_0214	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NT05HA_0218	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NT05HA_0221	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NT05HA_0222	COG0849	cell division
NT05HA_0223	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NT05HA_0227	COG1605	Chorismate mutase
NT05HA_0227	COG0077	Prephenate dehydratase
NT05HA_0230	COG0326	Molecular chaperone. Has ATPase activity
NT05HA_0231	COG1393	Belongs to the ArsC family
NT05HA_0235	COG1876	peptidase activity
NT05HA_0236	COG0494	nUDIX hydrolase
NT05HA_0237	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NT05HA_0243	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NT05HA_0245	COG0471	metal ion transport
NT05HA_0246	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NT05HA_0246	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
NT05HA_0247	COG3051	citrate lyase alpha subunit
NT05HA_0248	COG2301	Belongs to the HpcH HpaI aldolase family
NT05HA_0250	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
NT05HA_0251	COG4535	Mg2 and Co2 transporter CorC
NT05HA_0255	COG0105	UTP biosynthetic process
NT05HA_0256	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NT05HA_0259	COG3501	Rhs element vgr protein
NT05HA_0261	COG3209	COG3209 Rhs family protein
NT05HA_0267	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NT05HA_0268	COG1530	ribonuclease E activity
NT05HA_0269	COG2999	glutathione oxidoreductase activity
NT05HA_0270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NT05HA_0272	COG0725	ABC transporter, periplasmic molybdate-binding protein
NT05HA_0273	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NT05HA_0274	COG3842	ATPase activity
NT05HA_0275	COG0157	Belongs to the NadC ModD family
NT05HA_0278	COG4953	penicillin-binding protein 1C
NT05HA_0288	COG3501	Rhs element vgr protein
NT05HA_0292	COG3501	Rhs element vgr protein
NT05HA_0296	COG1823	symporter activity
NT05HA_0298	COG0795	lipopolysaccharide-transporting ATPase activity
NT05HA_0299	COG0795	lipopolysaccharide-transporting ATPase activity
NT05HA_0300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NT05HA_0302	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NT05HA_0305	COG0739	heme binding
NT05HA_0308	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NT05HA_0314	COG0617	tRNA 3'-terminal CCA addition
NT05HA_0315	COG4991	sh3 domain protein
NT05HA_0316	COG0306	phosphate transporter
NT05HA_0317	COG1392	Phosphate transport regulator
NT05HA_0318	COG3025	triphosphatase activity
NT05HA_0319	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NT05HA_0320	COG1522	sequence-specific DNA binding
NT05HA_0324	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NT05HA_0325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NT05HA_0335	COG1518	maintenance of DNA repeat elements
NT05HA_0337	COG2190	(PTS) system
NT05HA_0337	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NT05HA_0337	COG1263	PTS System
NT05HA_0339	COG0058	SHG alpha-glucan phosphorylase activity
NT05HA_0340	COG2188	Transcriptional regulator
NT05HA_0342	COG0583	DNA-binding transcription factor activity
NT05HA_0344	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NT05HA_0345	COG1687	branched-chain amino acid
NT05HA_0346	COG0612	Peptidase, M16
NT05HA_0347	COG4771	TonB-dependent receptor
NT05HA_0348	COG2990	Protein conserved in bacteria
NT05HA_0349	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NT05HA_0350	COG0539	negative regulation of cytoplasmic translation
NT05HA_0351	COG0776	regulation of translation
NT05HA_0352	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
NT05HA_0353	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NT05HA_0356	COG0023	Translation Initiation Factor
NT05HA_0357	COG3094	Invasion gene expression up-regulator, SirB
NT05HA_0358	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NT05HA_0360	COG0735	belongs to the Fur family
NT05HA_0361	COG0716	FMN binding
NT05HA_0363	COG0596	Alpha beta hydrolase
NT05HA_0364	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
NT05HA_0365	COG0318	PFAM AMP-dependent synthetase and ligase
NT05HA_0366	COG3264	Mechanosensitive ion channel
NT05HA_0366	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NT05HA_0368	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
NT05HA_0369	COG0730	response to heat
NT05HA_0370	COG1560	Kdo2-lipid A biosynthetic process
NT05HA_0371	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NT05HA_0372	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NT05HA_0373	COG3021	interspecies interaction between organisms
NT05HA_0374	COG0251	oxidation-reduction process
NT05HA_0377	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
NT05HA_0379	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NT05HA_0380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NT05HA_0381	COG0602	queuosine metabolic process
NT05HA_0382	COG0720	synthase
NT05HA_0385	COG2378	regulation of single-species biofilm formation
NT05HA_0389	COG1289	transmembrane transporter activity
NT05HA_0390	COG3304	Inner membrane component domain
NT05HA_0394	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NT05HA_0395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NT05HA_0396	COG1121	(ABC) transporter
NT05HA_0398	COG2920	part of a sulfur-relay system
NT05HA_0400	COG3105	Protein conserved in bacteria
NT05HA_0402	COG1944	ATP diphosphatase activity
NT05HA_0406	COG2226	methyltransferase
NT05HA_0409	COG1940	carbohydrate kinase activity
NT05HA_0409	COG1846	Transcriptional regulator
NT05HA_0414	COG0405	Gamma-glutamyltransferase
NT05HA_0417	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NT05HA_0421	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NT05HA_0423	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NT05HA_0424	COG1177	transmembrane transport
NT05HA_0425	COG1176	ABC-type spermidine putrescine transport system, permease component I
NT05HA_0426	COG3842	ATPase activity
NT05HA_0428	COG3008	intermembrane lipid transfer
NT05HA_0430	COG2995	paraquat-inducible protein a
NT05HA_0434	COG2989	Protein conserved in bacteria
NT05HA_0435	COG3108	Peptidase M15
NT05HA_0436	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NT05HA_0437	COG0567	Dehydrogenase, E1 component
NT05HA_0438	COG0508	dehydrogenase complex catalyzes the overall conversion of
NT05HA_0441	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NT05HA_0445	COG3070	regulator of competence-specific genes
NT05HA_0450	COG0745	RESPONSE REGULATOR receiver
NT05HA_0451	COG0642	Histidine kinase
NT05HA_0453	COG2814	Major facilitator Superfamily
NT05HA_0454	COG0375	protein maturation
NT05HA_0456	COG2252	PERMEase
NT05HA_0459	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NT05HA_0460	COG0825	malonyl-CoA metabolic process
NT05HA_0482	COG4626	Terminase
NT05HA_0482	COG1802	Transcriptional regulator
NT05HA_0516	COG0582	viral genome integration into host DNA
NT05HA_0520	COG3069	C4-dicarboxylate transmembrane transporter activity
NT05HA_0521	COG2233	PERMEase
NT05HA_0529	COG0516	GMP reductase activity
NT05HA_0529	COG0517	IMP dehydrogenase activity
NT05HA_0530	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NT05HA_0530	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NT05HA_0532	COG0351	phosphomethylpyrimidine kinase
NT05HA_0533	COG4143	(ABC) transporter
NT05HA_0534	COG1178	ABC-type Fe3 transport system permease component
NT05HA_0535	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
NT05HA_0540	COG1263	PTS System
NT05HA_0540	COG2190	(PTS) system
NT05HA_0540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NT05HA_0543	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
NT05HA_0543	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
NT05HA_0544	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NT05HA_0545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NT05HA_0547	COG1737	Transcriptional regulator
NT05HA_0548	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NT05HA_0549	COG0363	glucosamine-6-phosphate deaminase activity
NT05HA_0550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NT05HA_0552	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NT05HA_0555	COG0247	lactate metabolic process
NT05HA_0555	COG0277	FAD linked oxidase domain protein
NT05HA_0557	COG1704	LemA family
NT05HA_0562	COG2363	Small membrane protein
NT05HA_0563	COG1643	Atp-dependent helicase
NT05HA_0566	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NT05HA_0567	COG1136	(ABC) transporter
NT05HA_0567	COG0577	efflux transmembrane transporter activity
NT05HA_0569	COG0577	efflux transmembrane transporter activity
NT05HA_0572	COG0672	)-iron permease
NT05HA_0573	COG1556	Lactate utilization protein
NT05HA_0576	COG0247	lactate metabolic process
NT05HA_0577	COG1620	l-lactate permease
NT05HA_0579	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NT05HA_0580	COG3112	Uncharacterised protein family (UPF0231)
NT05HA_0581	COG0316	Belongs to the HesB IscA family
NT05HA_0582	COG0024	Methionine aminopeptidase
NT05HA_0584	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NT05HA_0585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NT05HA_0592	COG3787	Belongs to the UPF0306 family
NT05HA_0593	COG4172	Belongs to the ABC transporter superfamily
NT05HA_0594	COG4172	Belongs to the ABC transporter superfamily
NT05HA_0595	COG4171	peptide transport system, permease
NT05HA_0596	COG4168	peptide transport system, permease
NT05HA_0602	COG3106	COG3106 Predicted ATPase
NT05HA_0604	COG3283	Transcriptional regulator of aromatic amino acids metabolism
NT05HA_0605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NT05HA_0607	COG1923	regulation of RNA biosynthetic process
NT05HA_0609	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NT05HA_0610	COG0860	N-Acetylmuramoyl-L-alanine amidase
NT05HA_0610	COG1388	LysM domain
NT05HA_0611	COG0802	atpase or kinase
NT05HA_0613	COG2194	sulfuric ester hydrolase activity
NT05HA_0616	COG1162	GTPase activity
NT05HA_0617	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_0618	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NT05HA_0619	COG2190	(PTS) system
NT05HA_0620	COG0339	signal peptide processing
NT05HA_0621	COG2832	Protein of unknown function (DUF454)
NT05HA_0622	COG4166	transmembrane transport
NT05HA_0626	COG0671	phosphoesterase, PA-phosphatase related
NT05HA_0627	COG1940	carbohydrate kinase activity
NT05HA_0628	COG1216	Glycosyl transferase, family 2
NT05HA_0629	COG2951	lytic endotransglycosylase activity
NT05HA_0632	COG2246	polysaccharide biosynthetic process
NT05HA_0639	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NT05HA_0640	COG0708	Exodeoxyribonuclease III
NT05HA_0641	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NT05HA_0642	COG1088	dTDP-glucose 4,6-dehydratase activity
NT05HA_0645	COG0778	Nitroreductase
NT05HA_0646	COG0616	signal peptide processing
NT05HA_0647	COG0287	Prephenate dehydrogenase
NT05HA_0647	COG1605	Chorismate mutase
NT05HA_0648	COG0009	L-threonylcarbamoyladenylate synthase
NT05HA_0651	COG0583	DNA-binding transcription factor activity
NT05HA_0654	COG2351	hydroxyisourate hydrolase activity
NT05HA_0656	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
NT05HA_0657	COG0508	dehydrogenase complex catalyzes the overall conversion of
NT05HA_0658	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NT05HA_0660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NT05HA_0662	COG0512	Glutamine amidotransferase of anthranilate synthase
NT05HA_0663	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NT05HA_0666	COG1943	Transposase
NT05HA_0667	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT05HA_0675	COG4591	ABC-type transport system involved in lipoprotein release permease component
NT05HA_0677	COG4591	ABC-type transport system involved in lipoprotein release permease component
NT05HA_0680	COG0305	Participates in initiation and elongation during chromosome replication
NT05HA_0683	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NT05HA_0685	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NT05HA_0686	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NT05HA_0687	COG1280	lysine exporter protein (LysE YggA)
NT05HA_0689	COG0633	Ferredoxin
NT05HA_0690	COG0471	metal ion transport
NT05HA_0691	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NT05HA_0693	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NT05HA_0695	COG1840	ABC-type Fe3 transport system, periplasmic component
NT05HA_0697	COG3842	ATPase activity
NT05HA_0698	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NT05HA_0701	COG3955	Domain of unknown function (DUF1919)
NT05HA_0702	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NT05HA_0703	COG0785	Cytochrome C biogenesis protein
NT05HA_0704	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NT05HA_0704	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NT05HA_0705	COG0288	reversible hydration of carbon dioxide
NT05HA_0706	COG2823	Periplasmic or secreted lipoprotein
NT05HA_0707	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
NT05HA_0710	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NT05HA_0711	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NT05HA_0712	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NT05HA_0715	COG0616	signal peptide processing
NT05HA_0723	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NT05HA_0724	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NT05HA_0725	COG3738	Protein conserved in bacteria
NT05HA_0728	COG0142	geranyltranstransferase activity
NT05HA_0731	COG2819	hydrolase of the alpha beta superfamily
NT05HA_0733	COG0285	dihydrofolate synthase activity
NT05HA_0734	COG0588	phosphoglycerate mutase activity
NT05HA_0735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NT05HA_0736	COG2431	L-lysine efflux transmembrane transporter activity
NT05HA_0737	COG0564	pseudouridine synthase activity
NT05HA_0739	COG2824	Alkylphosphonate utilization operon protein PhnA
NT05HA_0744	COG1136	(ABC) transporter
NT05HA_0744	COG0577	efflux transmembrane transporter activity
NT05HA_0745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT05HA_0747	COG2983	Belongs to the UPF0260 family
NT05HA_0751	COG1523	belongs to the glycosyl hydrolase 13 family
NT05HA_0754	COG0058	SHG alpha-glucan phosphorylase activity
NT05HA_0756	COG0586	Pfam SNARE associated Golgi protein
NT05HA_0759	COG1686	Belongs to the peptidase S11 family
NT05HA_0760	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
NT05HA_0763	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
NT05HA_0764	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NT05HA_0765	COG0697	spore germination
NT05HA_0766	COG2925	Exonuclease
NT05HA_0767	COG1528	Iron-storage protein
NT05HA_0768	COG1528	Iron-storage protein
NT05HA_0770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NT05HA_0771	COG0589	response to stress
NT05HA_0772	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
NT05HA_0774	COG0583	DNA-binding transcription factor activity
NT05HA_0775	COG0613	PHP domain protein
NT05HA_0779	COG0308	aminopeptidase N
NT05HA_0780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NT05HA_0781	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NT05HA_0782	COG1448	Aminotransferase
NT05HA_0784	COG1120	ATPase activity
NT05HA_0786	COG3585	molybdate ion transport
NT05HA_0788	COG1309	transcriptional regulator
NT05HA_0789	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT05HA_0792	COG0842	Transport permease protein
NT05HA_0793	COG1538	Outer membrane efflux protein
NT05HA_0797	COG0791	NLP P60 protein
NT05HA_0800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NT05HA_0801	COG0501	Belongs to the peptidase M48B family
NT05HA_0805	COG0517	IMP dehydrogenase activity
NT05HA_0805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NT05HA_0806	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NT05HA_0807	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NT05HA_0808	COG0512	Glutamine amidotransferase of anthranilate synthase
NT05HA_0809	COG1942	4-Oxalocrotonate Tautomerase
NT05HA_0811	COG0134	indole-3-glycerol-phosphate synthase activity
NT05HA_0811	COG0135	phosphoribosylanthranilate isomerase activity
NT05HA_0812	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
NT05HA_0813	COG0437	4 iron, 4 sulfur cluster binding
NT05HA_0814	COG5557	Pfam Polysulphide reductase, NrfD
NT05HA_0815	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
NT05HA_0816	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NT05HA_0817	COG1773	rubredoxin
NT05HA_0818	COG0298	carbon dioxide binding
NT05HA_0821	COG3630	sodium ion export across plasma membrane
NT05HA_0822	COG0511	ligase activity, forming carbon-carbon bonds
NT05HA_0822	COG5016	pyruvate
NT05HA_0824	COG4221	oxidoreductase activity
NT05HA_0825	COG0133	tryptophan synthase activity
NT05HA_0827	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NT05HA_0829	COG0469	pyruvate kinase activity
NT05HA_0832	COG1879	ABC-type sugar transport system periplasmic component
NT05HA_0836	COG2390	Transcriptional regulator
NT05HA_0843	COG2969	positive regulation of protein catabolic process
NT05HA_0845	COG0314	molybdopterin synthase activity
NT05HA_0846	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NT05HA_0848	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NT05HA_0853	COG3005	denitrification pathway
NT05HA_0856	COG3005	denitrification pathway
NT05HA_0857	COG0243	molybdopterin cofactor binding
NT05HA_0858	COG2315	Protein conserved in bacteria
NT05HA_0860	COG0366	Alpha amylase catalytic
NT05HA_0861	COG1263	PTS System
NT05HA_0861	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NT05HA_0862	COG0101	tRNA pseudouridine synthase activity
NT05HA_0866	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NT05HA_0867	COG1074	ATP-dependent DNA helicase activity
NT05HA_0868	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NT05HA_0869	COG2252	PERMEase
NT05HA_0871	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NT05HA_0872	COG1067	ATP-dependent peptidase activity
NT05HA_0874	COG1278	Cold shock
NT05HA_0877	COG3098	single-species biofilm formation
NT05HA_0878	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
NT05HA_0879	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NT05HA_0879	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NT05HA_0880	COG3101	peptidyl-lysine hydroxylation
NT05HA_0881	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NT05HA_0883	COG0788	formyltetrahydrofolate deformylase activity
NT05HA_0884	COG2916	Histone family protein nucleoid-structuring protein H-NS
NT05HA_0885	COG1757	Na H antiporter
NT05HA_0897	COG1609	Transcriptional regulator
NT05HA_0898	COG2949	membrane
NT05HA_0899	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NT05HA_0903	COG3099	Belongs to the UPF0263 family
NT05HA_0904	COG4178	(ABC) transporter
NT05HA_0905	COG4774	siderophore transport
NT05HA_0907	COG0307	riboflavin synthase, alpha
NT05HA_0908	COG1534	Rna-binding protein
NT05HA_0909	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NT05HA_0910	COG2027	D-alanyl-D-alanine carboxypeptidase
NT05HA_0912	COG0303	'Molybdopterin
NT05HA_0913	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NT05HA_0915	COG4580	involved in the transport of maltose and maltodextrins
NT05HA_0917	COG3842	ATPase activity
NT05HA_0918	COG2182	Extracellular solute-binding protein
NT05HA_0919	COG2182	Extracellular solute-binding protein
NT05HA_0921	COG3833	ABC-type maltose transport systems, permease component
NT05HA_0922	COG0366	Alpha amylase catalytic
NT05HA_0940	COG2909	trisaccharide binding
NT05HA_0941	COG0058	SHG alpha-glucan phosphorylase activity
NT05HA_0942	COG1640	4-alpha-glucanotransferase
NT05HA_0944	COG0163	prenyltransferase activity
NT05HA_0946	COG1286	toxin biosynthetic process
NT05HA_0948	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NT05HA_0949	COG0857	belongs to the CobB CobQ family
NT05HA_0949	COG0280	phosphate acetyltransferase
NT05HA_0952	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NT05HA_0953	COG0617	tRNA 3'-terminal CCA addition
NT05HA_0955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NT05HA_0957	COG0658	competence protein
NT05HA_0957	COG2333	competence protein COMEC
NT05HA_0958	COG1132	(ABC) transporter
NT05HA_0959	COG1663	tetraacyldisaccharide 4'-kinase activity
NT05HA_0960	COG2835	tetraacyldisaccharide 4'-kinase activity
NT05HA_0962	COG0322	excinuclease ABC activity
NT05HA_0968	COG1176	ABC-type spermidine putrescine transport system, permease component I
NT05HA_0969	COG1175	transmembrane transport
NT05HA_0972	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NT05HA_0973	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NT05HA_0977	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NT05HA_0978	COG1621	beta-fructofuranosidase activity
NT05HA_0981	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NT05HA_0983	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NT05HA_0984	COG0195	Participates in both transcription termination and antitermination
NT05HA_0988	COG3100	YcgL domain-containing protein
NT05HA_0991	COG2062	phosphohistidine phosphatase, SixA
NT05HA_0993	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NT05HA_0994	COG2962	Rard protein
NT05HA_0995	COG1522	sequence-specific DNA binding
NT05HA_0996	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NT05HA_0999	COG2932	Transcriptional regulator
NT05HA_1001	COG2801	Transposase and inactivated derivatives
NT05HA_1002	COG0791	NLP P60 protein
NT05HA_1004	COG2890	protein-(glutamine-N5) methyltransferase activity
NT05HA_1006	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NT05HA_1007	COG3133	Outer membrane lipoprotein
NT05HA_1008	COG3102	Protein conserved in bacteria
NT05HA_1011	COG5339	Protein conserved in bacteria
NT05HA_1012	COG0443	Heat shock 70 kDa protein
NT05HA_1013	COG1403	HNH endonuclease
NT05HA_1014	COG0484	heat shock protein binding
NT05HA_1016	COG0626	cystathionine gamma-synthase activity
NT05HA_1017	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NT05HA_1021	COG0305	Participates in initiation and elongation during chromosome replication
NT05HA_1034	COG0629	single-stranded DNA binding
NT05HA_1041	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NT05HA_1043	COG3219	Protein conserved in bacteria
NT05HA_1044	COG3220	belongs to the UPF0276 family
NT05HA_1046	COG2259	Doxx family
NT05HA_1056	COG1858	cytochrome C peroxidase
NT05HA_1057	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NT05HA_1058	COG0318	PFAM AMP-dependent synthetase and ligase
NT05HA_1059	COG3065	identical protein binding
NT05HA_1060	COG1214	PFAM Peptidase M22, glycoprotease
NT05HA_1061	COG1199	ATP-dependent helicase activity
NT05HA_1062	COG0676	glucose-6-phosphate 1-epimerase activity
NT05HA_1064	COG1174	glycine betaine transport
NT05HA_1065	COG1125	glycine betaine transport
NT05HA_1065	COG0517	IMP dehydrogenase activity
NT05HA_1067	COG3118	belongs to the thioredoxin family
NT05HA_1068	COG0492	ferredoxin-NADP+ reductase activity
NT05HA_1071	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NT05HA_1072	COG1946	Acyl-CoA thioesterase
NT05HA_1074	COG0515	serine threonine protein kinase
NT05HA_1077	COG1216	Glycosyl transferase, family 2
NT05HA_1079	COG3306	glycosyltransferase involved in LPS biosynthesis
NT05HA_1081	COG5039	Polysaccharide pyruvyl transferase
NT05HA_1082	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NT05HA_1084	COG1793	dna ligase
NT05HA_1086	COG0210	DNA helicase
NT05HA_1087	COG2610	gluconate transmembrane transporter activity
NT05HA_1088	COG3265	gluconokinase activity
NT05HA_1090	COG1609	Transcriptional regulator
NT05HA_1094	COG0437	4 iron, 4 sulfur cluster binding
NT05HA_1095	COG2864	formate dehydrogenase
NT05HA_1096	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NT05HA_1097	COG4149	molybdate abc transporter
NT05HA_1098	COG0725	ABC transporter, periplasmic molybdate-binding protein
NT05HA_1099	COG2005	Transcriptional regulator
NT05HA_1101	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NT05HA_1102	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NT05HA_1102	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NT05HA_1103	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NT05HA_1105	COG0583	DNA-binding transcription factor activity
NT05HA_1108	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NT05HA_1110	COG1438	arginine binding
NT05HA_1111	COG1090	epimerase
NT05HA_1113	COG4657	Part of a membrane complex involved in electron transport
NT05HA_1115	COG4656	Part of a membrane complex involved in electron transport
NT05HA_1119	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NT05HA_1122	COG3958	Transketolase
NT05HA_1123	COG3959	Transketolase, thiamine diphosphate binding domain
NT05HA_1130	COG1346	cytolysis
NT05HA_1132	COG0425	Belongs to the sulfur carrier protein TusA family
NT05HA_1133	COG2391	methyltransferase activity
NT05HA_1135	COG1525	nuclease
NT05HA_1136	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NT05HA_1137	COG2166	iron-sulfur cluster assembly
NT05HA_1138	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NT05HA_1138	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NT05HA_1139	COG1560	Kdo2-lipid A biosynthetic process
NT05HA_1140	COG3381	protein complex oligomerization
NT05HA_1141	COG2249	NAD(P)H dehydrogenase (quinone) activity
NT05HA_1143	COG0330	HflC and HflK could
NT05HA_1144	COG0737	Belongs to the 5'-nucleotidase family
NT05HA_1145	COG1629	transport
NT05HA_1145	COG4771	TonB-dependent receptor
NT05HA_1146	COG4607	ABC-type enterochelin transport system periplasmic component
NT05HA_1147	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT05HA_1148	COG4605	iron ion homeostasis
NT05HA_1149	COG4604	ABC transporter, ATP-binding protein
NT05HA_1150	COG3383	formate dehydrogenase (NAD+) activity
NT05HA_1151	COG3383	formate dehydrogenase (NAD+) activity
NT05HA_1153	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NT05HA_1155	COG3260	NADH ubiquinone oxidoreductase 20
NT05HA_1157	COG3261	NADH dehydrogenase
NT05HA_1157	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
NT05HA_1158	COG0651	ATP synthesis coupled electron transport
NT05HA_1159	COG4237	Hydrogenase 4 membrane
NT05HA_1160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NT05HA_1161	COG0650	Formate hydrogenlyase subunit 4
NT05HA_1162	COG0651	ATP synthesis coupled electron transport
NT05HA_1163	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NT05HA_1164	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NT05HA_1165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NT05HA_1169	COG0309	Hydrogenase expression formation protein (HypE)
NT05HA_1170	COG0409	Hydrogenase expression formation protein
NT05HA_1171	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NT05HA_1172	COG1122	ATPase activity
NT05HA_1173	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NT05HA_1174	COG0310	cobalt ion transport
NT05HA_1175	COG0310	cobalt ion transport
NT05HA_1176	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
NT05HA_1177	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NT05HA_1178	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT05HA_1179	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NT05HA_1180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT05HA_1192	COG1840	ABC-type Fe3 transport system, periplasmic component
NT05HA_1194	COG1840	ABC-type Fe3 transport system, periplasmic component
NT05HA_1199	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NT05HA_1200	COG1959	2 iron, 2 sulfur cluster binding
NT05HA_1202	COG0822	iron-sulfur transferase activity
NT05HA_1204	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NT05HA_1205	COG0443	Heat shock 70 kDa protein
NT05HA_1206	COG0633	Ferredoxin
NT05HA_1207	COG2975	iron-sulfur cluster assembly
NT05HA_1208	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NT05HA_1208	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NT05HA_1209	COG0489	protein tyrosine kinase activity
NT05HA_1210	COG3683	transport system, periplasmic component
NT05HA_1211	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
NT05HA_1215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NT05HA_1216	COG0488	(ABC) transporter
NT05HA_1219	COG0187	DNA topoisomerase II activity
NT05HA_1220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NT05HA_1223	COG0783	Belongs to the Dps family
NT05HA_1224	COG1566	PFAM secretion protein HlyD family protein
NT05HA_1225	COG2814	Major facilitator Superfamily
NT05HA_1226	COG1840	ABC-type Fe3 transport system, periplasmic component
NT05HA_1228	COG3550	peptidyl-serine autophosphorylation
NT05HA_1232	COG2927	DNA polymerase III (CHI subunit)
NT05HA_1233	COG0114	fumarate hydratase activity
NT05HA_1234	COG2268	Band 7 protein
NT05HA_1237	COG0778	Nitroreductase
NT05HA_1238	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NT05HA_1241	COG0814	amino acid
NT05HA_1243	COG0235	Class ii aldolase
NT05HA_1244	COG3623	hexulose-6-phosphate isomerase
NT05HA_1248	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_1249	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NT05HA_1256	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NT05HA_1257	COG2017	converts alpha-aldose to the beta-anomer
NT05HA_1258	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NT05HA_1259	COG1085	galactose-1-phosphate uridylyltransferase
NT05HA_1260	COG1609	Transcriptional regulator
NT05HA_1261	COG1879	ABC-type sugar transport system periplasmic component
NT05HA_1263	COG4211	Belongs to the binding-protein-dependent transport system permease family
NT05HA_1265	COG5002	protein histidine kinase activity
NT05HA_1265	COG0784	Response regulator, receiver
NT05HA_1265	COG2198	Histidine kinase
NT05HA_1266	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NT05HA_1267	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NT05HA_1267	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NT05HA_1268	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NT05HA_1268	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NT05HA_1271	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NT05HA_1273	COG0497	DNA recombination
NT05HA_1276	COG2917	probably involved in intracellular septation
NT05HA_1277	COG1607	acyl-coa hydrolase
NT05HA_1278	COG2350	Protein conserved in bacteria
NT05HA_1279	COG0741	lytic transglycosylase activity
NT05HA_1281	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NT05HA_1285	COG4133	protoheme IX ABC transporter activity
NT05HA_1289	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NT05HA_1290	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NT05HA_1293	COG1408	metallophosphoesterase
NT05HA_1294	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NT05HA_1295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT05HA_1296	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT05HA_1297	COG1120	ATPase activity
NT05HA_1299	COG1053	succinate dehydrogenase
NT05HA_1300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NT05HA_1302	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
NT05HA_1304	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NT05HA_1305	COG0343	queuine tRNA-ribosyltransferase activity
NT05HA_1306	COG3945	hemerythrin HHE cation binding domain
NT05HA_1308	COG1862	Preprotein translocase
NT05HA_1309	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NT05HA_1310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NT05HA_1312	COG1454	alcohol dehydrogenase
NT05HA_1312	COG1012	belongs to the aldehyde dehydrogenase family
NT05HA_1313	COG0673	inositol 2-dehydrogenase activity
NT05HA_1315	COG2271	Major facilitator Superfamily
NT05HA_1317	COG3718	enzyme involved in inositol metabolism
NT05HA_1318	COG1737	Transcriptional regulator
NT05HA_1319	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NT05HA_1320	COG3962	Belongs to the TPP enzyme family
NT05HA_1322	COG0673	inositol 2-dehydrogenase activity
NT05HA_1328	COG0151	Belongs to the GarS family
NT05HA_1329	COG0138	bifunctional purine biosynthesis protein purh
NT05HA_1331	COG2813	Specifically methylates the guanine in position
NT05HA_1332	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
NT05HA_1333	COG0456	acetyltransferase
NT05HA_1334	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NT05HA_1337	COG4795	General secretion pathway protein
NT05HA_1338	COG2165	general secretion pathway protein
NT05HA_1346	COG0848	biopolymer transport protein
NT05HA_1347	COG0811	peptide transport
NT05HA_1348	COG0824	Thioesterase
NT05HA_1349	COG1294	oxidase, subunit
NT05HA_1350	COG1271	oxidase subunit
NT05HA_1353	COG0632	four-way junction helicase activity
NT05HA_1357	COG0494	nUDIX hydrolase
NT05HA_1360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NT05HA_1363	COG2271	Major facilitator Superfamily
NT05HA_1366	COG0346	lactoylglutathione lyase activity
NT05HA_1367	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NT05HA_1368	COG2056	Na+-H+ antiporter family
NT05HA_1372	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT05HA_1373	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NT05HA_1375	COG0142	geranyltranstransferase activity
NT05HA_1378	COG0697	spore germination
NT05HA_1379	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NT05HA_1383	COG4166	transmembrane transport
NT05HA_1384	COG0601	transmembrane transport
NT05HA_1385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NT05HA_1386	COG0444	Belongs to the ABC transporter superfamily
NT05HA_1387	COG4608	Belongs to the ABC transporter superfamily
NT05HA_1388	COG0745	RESPONSE REGULATOR receiver
NT05HA_1389	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NT05HA_1394	COG2259	Doxx family
NT05HA_1396	COG1530	ribonuclease E activity
NT05HA_1399	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NT05HA_1400	COG0626	cystathionine gamma-synthase activity
NT05HA_1404	COG0527	aspartate kinase activity
NT05HA_1407	COG5295	Hep Hag repeat protein
NT05HA_1409	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NT05HA_1412	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NT05HA_1413	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NT05HA_1414	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
NT05HA_1415	COG0475	glutathione-regulated potassium exporter activity
NT05HA_1415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NT05HA_1416	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NT05HA_1421	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NT05HA_1423	COG2867	negative regulation of translational initiation
NT05HA_1425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NT05HA_1427	COG1758	RNA polymerase activity
NT05HA_1428	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NT05HA_1430	COG3161	chorismate lyase activity
NT05HA_1431	COG2850	peptidyl-arginine hydroxylation
NT05HA_1433	COG1660	Displays ATPase and GTPase activities
NT05HA_1434	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_1435	COG1137	ATPase activity
NT05HA_1436	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NT05HA_1437	COG3117	lipopolysaccharide transmembrane transporter activity
NT05HA_1438	COG1127	ABC transporter
NT05HA_1439	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NT05HA_1440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NT05HA_1441	COG2854	intermembrane phospholipid transfer
NT05HA_1442	COG3113	response to antibiotic
NT05HA_1443	COG5007	Belongs to the BolA IbaG family
NT05HA_1445	COG3028	Belongs to the UPF0307 family
NT05HA_1446	COG0312	modulator of DNA gyrase
NT05HA_1447	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NT05HA_1448	COG1929	Belongs to the glycerate kinase type-1 family
NT05HA_1449	COG2610	gluconate transmembrane transporter activity
NT05HA_1450	COG3835	regulator
NT05HA_1455	COG1132	(ABC) transporter
NT05HA_1458	COG0513	Belongs to the DEAD box helicase family
NT05HA_1459	COG4785	May be involved in cell division
NT05HA_1461	COG2731	YhcH YjgK YiaL family protein
NT05HA_1462	COG3023	N-Acetylmuramoyl-L-alanine amidase
NT05HA_1464	COG4969	Belongs to the N-Me-Phe pilin family
NT05HA_1465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NT05HA_1466	COG1459	type II secretion system
NT05HA_1467	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NT05HA_1468	COG0237	dephospho-CoA kinase activity
NT05HA_1468	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NT05HA_1471	COG1115	amino acid carrier protein
NT05HA_1481	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NT05HA_1484	COG4145	pantothenate transmembrane transporter activity
NT05HA_1485	COG3924	membrane
NT05HA_1487	COG0084	hydrolase, TatD family'
NT05HA_1488	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NT05HA_1495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NT05HA_1495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NT05HA_1496	COG0772	Belongs to the SEDS family
NT05HA_1497	COG0768	penicillin binding
NT05HA_1499	COG0799	negative regulation of ribosome biogenesis
NT05HA_1500	COG0513	Belongs to the DEAD box helicase family
NT05HA_1501	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NT05HA_1502	COG2814	Major facilitator Superfamily
NT05HA_1504	COG1028	Short-chain dehydrogenase reductase Sdr
NT05HA_1505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NT05HA_1507	COG0416	fatty acid biosynthetic process
NT05HA_1508	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NT05HA_1509	COG1399	metal-binding, possibly nucleic acid-binding protein
NT05HA_1511	COG2226	methyltransferase
NT05HA_1512	COG2830	Protein of unknown function (DUF452)
NT05HA_1514	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NT05HA_1515	COG0500	methyltransferase
NT05HA_1517	COG0671	phosphoesterase, PA-phosphatase related
NT05HA_1517	COG2453	phosphatase
NT05HA_1518	COG2267	carboxylic ester hydrolase activity
NT05HA_1519	COG0688	phosphatidylethanolamine metabolic process
NT05HA_1520	COG0545	Peptidyl-prolyl cis-trans isomerase
NT05HA_1522	COG2966	Psort location CytoplasmicMembrane, score
NT05HA_1523	COG3610	response to peptide
NT05HA_1524	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NT05HA_1525	COG1253	flavin adenine dinucleotide binding
NT05HA_1527	COG0084	hydrolase, TatD family'
NT05HA_1528	COG0470	DNA polymerase III
NT05HA_1529	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NT05HA_1530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NT05HA_1531	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NT05HA_1532	COG0628	permease
NT05HA_1533	COG0347	Belongs to the P(II) protein family
NT05HA_1535	COG0561	phosphatase activity
NT05HA_1542	COG0521	Mo-molybdopterin cofactor biosynthetic process
NT05HA_1543	COG4589	Belongs to the CDS family
NT05HA_1545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NT05HA_1546	COG0471	metal ion transport
NT05HA_1546	COG0490	domain, Protein
NT05HA_1550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NT05HA_1552	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
NT05HA_1555	COG0575	Belongs to the CDS family
NT05HA_1559	COG0233	cytoplasmic translational termination
NT05HA_1562	COG4178	(ABC) transporter
NT05HA_1566	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NT05HA_1567	COG0066	3-isopropylmalate dehydratase activity
NT05HA_1569	COG2226	methyltransferase
NT05HA_1570	COG0814	amino acid
NT05HA_1572	COG4783	chaperone-mediated protein folding
NT05HA_1574	COG0848	biopolymer transport protein
NT05HA_1575	COG0811	peptide transport
NT05HA_1576	COG4536	flavin adenine dinucleotide binding
NT05HA_1577	COG4137	Cytochrome C assembly protein
NT05HA_1578	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NT05HA_1586	COG0758	DNA mediated transformation
NT05HA_1587	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NT05HA_1591	COG2183	response to ionizing radiation
NT05HA_1592	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NT05HA_1594	COG1595	DNA-templated transcription, initiation
NT05HA_1596	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NT05HA_1597	COG3071	HemY protein
NT05HA_1598	COG2959	enzyme of heme biosynthesis
NT05HA_1600	COG0181	hydroxymethylbilane synthase activity
NT05HA_1602	COG2197	response regulator
NT05HA_1603	COG0729	surface antigen
NT05HA_1604	COG2911	Protein conserved in bacteria
NT05HA_1605	COG0248	Ppx GppA phosphatase
NT05HA_1609	COG2991	Protein conserved in bacteria
NT05HA_1610	COG1477	protein flavinylation
NT05HA_1612	COG2871	sodium ion transport
NT05HA_1613	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NT05HA_1614	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NT05HA_1615	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
NT05HA_1618	COG0271	Belongs to the BolA IbaG family
NT05HA_1619	COG3056	Lipoprotein
NT05HA_1624	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NT05HA_1625	COG1194	a g-specific adenine glycosylase
NT05HA_1629	COG3171	Protein conserved in bacteria
NT05HA_1630	COG1132	(ABC) transporter
NT05HA_1631	COG1132	(ABC) transporter
NT05HA_1632	COG4977	sequence-specific DNA binding
NT05HA_1632	COG1917	Cupin 2, conserved barrel domain protein
NT05HA_1633	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NT05HA_1634	COG0859	PFAM glycosyl transferase family 9
NT05HA_1638	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NT05HA_1640	COG1840	ABC-type Fe3 transport system, periplasmic component
NT05HA_1644	COG1178	ABC-type Fe3 transport system permease component
NT05HA_1645	COG3842	ATPase activity
NT05HA_1647	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NT05HA_1649	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NT05HA_1650	COG1561	YicC-like family, N-terminal region
NT05HA_1651	COG0354	folic acid binding
NT05HA_1655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NT05HA_1656	COG1381	Involved in DNA repair and RecF pathway recombination
NT05HA_1657	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NT05HA_1658	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NT05HA_1659	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NT05HA_1663	COG2177	Part of the ABC transporter FtsEX involved in
NT05HA_1664	COG2884	Cell division ATP-binding protein ftsE
NT05HA_1665	COG0552	protein localization to endoplasmic reticulum
NT05HA_1666	COG0742	ribosomal rna small subunit methyltransferase
NT05HA_1667	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_1667	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NT05HA_1668	COG3715	PTS system
NT05HA_1669	COG3716	PTS system mannose fructose sorbose family IID component
NT05HA_1670	COG0561	phosphatase activity
NT05HA_1672	COG2271	Major facilitator Superfamily
NT05HA_1673	COG1120	ATPase activity
NT05HA_1679	COG1215	transferase activity, transferring glycosyl groups
NT05HA_1680	COG0726	polysaccharide deacetylase
NT05HA_1680	COG1649	PFAM Uncharacterised BCR, COG1649
NT05HA_1683	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NT05HA_1684	COG0859	PFAM glycosyl transferase family 9
NT05HA_1685	COG1027	Aspartate ammonia-lyase
NT05HA_1686	COG3030	protein affecting phage T7 exclusion by the F plasmid
NT05HA_1687	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NT05HA_1688	COG0459	protein refolding
NT05HA_1692	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NT05HA_1694	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NT05HA_1696	COG1011	Hydrolase
NT05HA_1701	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NT05HA_1715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NT05HA_1717	COG1028	Short-chain dehydrogenase reductase Sdr
NT05HA_1718	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NT05HA_1719	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NT05HA_1720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NT05HA_1722	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NT05HA_1723	COG3719	Belongs to the RNase T2 family
NT05HA_1725	COG0191	fructose-bisphosphate aldolase activity
NT05HA_1726	COG3307	-O-antigen
NT05HA_1727	COG2267	carboxylic ester hydrolase activity
NT05HA_1728	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NT05HA_1729	COG0561	phosphatase activity
NT05HA_1731	COG0028	Belongs to the TPP enzyme family
NT05HA_1735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NT05HA_1737	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NT05HA_1740	COG1131	(ABC) transporter
NT05HA_1741	COG0842	Transport permease protein
NT05HA_1750	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
NT05HA_1752	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NT05HA_1754	COG2960	long-chain fatty acid transporting porin activity
NT05HA_1755	COG3172	ATPase kinase involved in NAD metabolism
NT05HA_1756	COG2129	metallophosphoesterase
NT05HA_1757	COG0814	amino acid
NT05HA_1759	COG1555	photosystem II stabilization
NT05HA_1763	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NT05HA_1764	COG0561	phosphatase activity
NT05HA_1765	COG1040	competence protein
NT05HA_1769	COG0107	imidazoleglycerol-phosphate synthase activity
NT05HA_1772	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NT05HA_1774	COG0131	Imidazoleglycerol-phosphate dehydratase
NT05HA_1774	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NT05HA_1775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NT05HA_1776	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NT05HA_1777	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NT05HA_1778	COG1114	Component of the transport system for branched-chain amino acids
NT05HA_1784	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NT05HA_1786	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NT05HA_1790	COG0589	response to stress
NT05HA_1791	COG3956	TIGRFAM MazG family protein
NT05HA_1792	COG0402	S-adenosylhomocysteine deaminase activity
NT05HA_1793	COG3083	sulfuric ester hydrolase activity
NT05HA_1796	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NT05HA_1797	COG0745	RESPONSE REGULATOR receiver
NT05HA_1798	COG2205	protein histidine kinase activity
NT05HA_1799	COG0786	glutamate:sodium symporter activity
NT05HA_1802	COG3012	SEC-C Motif Domain Protein
NT05HA_1803	COG2258	MOSC domain
NT05HA_1804	COG0433	COG0433 Predicted ATPase
NT05HA_1806	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NT05HA_1807	COG1349	DNA-binding transcription factor activity
NT05HA_1809	COG3068	Protein conserved in bacteria
NT05HA_1810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NT05HA_1814	COG0222	ribosome binding
NT05HA_1815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NT05HA_1819	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NT05HA_1822	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
NT05HA_1838	COG0582	viral genome integration into host DNA
NT05HA_1841	COG3177	Filamentation induced by cAMP protein fic
NT05HA_1846	COG0513	Belongs to the DEAD box helicase family
NT05HA_1848	COG3201	nicotinamide mononucleotide transporter
NT05HA_1850	COG0564	pseudouridine synthase activity
NT05HA_1865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NT05HA_1873	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NT05HA_1873	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NT05HA_1873	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NT05HA_1874	COG1105	Belongs to the carbohydrate kinase PfkB family
NT05HA_1875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_1875	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT05HA_1877	COG0746	molybdenum cofactor guanylyltransferase activity
NT05HA_1878	COG3084	Protein conserved in bacteria
NT05HA_1879	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT05HA_1880	COG3085	chromosome segregation
NT05HA_1894	COG0742	ribosomal rna small subunit methyltransferase
NT05HA_1895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NT05HA_1897	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NT05HA_1901	COG0754	glutathionylspermidine amidase activity
NT05HA_1903	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NT05HA_1903	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NT05HA_1905	COG5645	(Lipo)protein
NT05HA_1906	COG0210	DNA helicase
NT05HA_1911	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NT05HA_1912	COG0110	maltose O-acetyltransferase activity
NT05HA_1913	COG1238	metal cluster binding
NT05HA_1915	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NT05HA_1920	COG1349	DNA-binding transcription factor activity
NT05HA_1921	COG0606	chelatase, subunit chli
NT05HA_1929	COG2861	carbohydrate metabolic process
NT05HA_1930	COG4942	peptidase
NT05HA_1932	COG2354	Protein conserved in bacteria
NT05HA_1936	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NT05HA_1941	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NT05HA_1943	COG2095	MarC family integral membrane protein
NT05HA_1948	COG0546	phosphoglycolate phosphatase activity
NT05HA_1949	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NT05HA_1953	COG0585	pseudouridine synthase activity
NT05HA_1955	COG1238	metal cluster binding
NT05HA_1957	COG1388	LysM domain
NT05HA_1957	COG4942	peptidase
NT05HA_1962	COG2814	Major facilitator Superfamily
NT05HA_1963	COG1763	Mo-molybdopterin cofactor biosynthetic process
NT05HA_1964	COG3086	response to oxidative stress
NT05HA_1965	COG3026	antisigma factor binding
NT05HA_1966	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
NT05HA_1967	COG1595	DNA-templated transcription, initiation
NT05HA_1971	COG0442	prolyl-tRNA aminoacylation
NT05HA_1972	COG1921	L-seryl-tRNASec selenium transferase activity
NT05HA_1973	COG3276	selenocysteine insertion sequence binding
NT05HA_1975	COG1902	pentaerythritol trinitrate reductase activity
NT05HA_1976	COG1285	pathogenesis
NT05HA_1978	COG0733	neurotransmitter:sodium symporter activity
NT05HA_1980	COG1132	(ABC) transporter
NT05HA_1981	COG4988	ABC transporter
NT05HA_1982	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NT05HA_1983	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NT05HA_1984	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NT05HA_1986	COG1045	serine acetyltransferase
NT05HA_1988	COG1494	fructose-1,6-bisphosphatase
NT05HA_1989	COG3074	FtsZ-dependent cytokinesis
NT05HA_1990	COG0716	FMN binding
NT05HA_1992	COG0357	Ribosomal RNA small subunit methyltransferase G
NT05HA_1993	COG3312	ion transport
NT05HA_1996	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NT05HA_1997	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NT05HA_1999	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NT05HA_2003	COG0859	PFAM glycosyl transferase family 9
NT05HA_2006	COG0737	Belongs to the 5'-nucleotidase family
NT05HA_2007	COG1309	transcriptional regulator
NT05HA_2008	COG0583	DNA-binding transcription factor activity
NT05HA_2009	COG0678	peroxiredoxin activity
NT05HA_2009	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NT05HA_2010	COG0754	glutathionylspermidine amidase activity
NT05HA_2011	COG3005	denitrification pathway
NT05HA_2012	COG3043	anaerobic respiration
NT05HA_2013	COG0348	domain, Protein
NT05HA_2014	COG0437	4 iron, 4 sulfur cluster binding
NT05HA_2015	COG0243	molybdopterin cofactor binding
NT05HA_2016	COG3062	negative regulation of establishment of protein localization
NT05HA_2017	COG3850	Histidine kinase
NT05HA_2020	COG1275	C4-dicarboxylate transporter malic acid transport protein
NT05HA_2021	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NT05HA_2022	COG2195	Cleaves the N-terminal amino acid of tripeptides
NT05HA_2026	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NT05HA_2027	COG2818	Glycosylase
NT05HA_2029	COG3477	response to acidic pH
NT05HA_2030	COG0019	diaminopimelate decarboxylase activity
NT05HA_2033	COG0514	ATP-dependent DNA helicase (RecQ)
NT05HA_2034	COG0187	DNA topoisomerase II activity
NT05HA_2035	COG1072	(Pantothenic acid kinase))
NT05HA_2041	COG1126	abc transporter atp-binding protein
NT05HA_2042	COG0765	amino acid transport
NT05HA_2043	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT05HA_2044	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NT05HA_2046	COG0545	Peptidyl-prolyl cis-trans isomerase
NT05HA_2047	COG2964	Protein conserved in bacteria
NT05HA_2048	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NT05HA_2050	COG2168	tRNA wobble position uridine thiolation
NT05HA_2052	COG0840	transmembrane signaling receptor activity
NT05HA_2053	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NT05HA_2060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NT05HA_2064	COG0702	epimerase
NT05HA_2065	COG1733	regulation of RNA biosynthetic process
NT05HA_2066	COG0752	glycyl-tRNA synthetase alpha subunit
NT05HA_2068	COG4545	Glutaredoxin-related protein
NT05HA_2072	COG0751	glycine-tRNA ligase activity
NT05HA_2074	COG0805	protein transport
NT05HA_2079	COG3165	ubiquinone biosynthetic process from chorismate
NT05HA_2082	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NT05HA_2083	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NT05HA_2084	COG1011	Hydrolase
NT05HA_2085	COG0494	nUDIX hydrolase
NT05HA_2086	COG4977	sequence-specific DNA binding
NT05HA_2086	COG1917	Cupin 2, conserved barrel domain protein
NT05HA_2087	COG3059	membrane
NT05HA_2088	COG1297	OPT oligopeptide transporter protein
NT05HA_2090	COG1218	3'(2'),5'-bisphosphate nucleotidase
NT05HA_2091	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NT05HA_2092	COG0363	glucosamine-6-phosphate deaminase activity
NT05HA_2097	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NT05HA_2104	COG0747	negative chemotaxis
NT05HA_2105	COG2853	Lipoprotein
NT05HA_2108	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NT05HA_2121	COG3501	Rhs element vgr protein
NT05HA_2125	COG2990	Protein conserved in bacteria
NT05HA_2126	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NT05HA_2130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NT05HA_2131	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NT05HA_2140	COG0569	domain protein
NT05HA_2141	COG1970	mechanosensitive ion channel activity
NT05HA_2142	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
NT05HA_2145	COG2841	Protein conserved in bacteria
NT05HA_2146	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NT05HA_2147	COG3914	O-linked N-acetylglucosamine transferase SPINDLY family
NT05HA_2148	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NT05HA_2149	COG3036	rescue of stalled ribosome
NT05HA_2151	COG1393	Belongs to the ArsC family
NT05HA_2153	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
NT05HA_2154	COG1522	sequence-specific DNA binding
NT05HA_2156	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NT05HA_2157	COG0038	chloride channel
NT05HA_2158	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NT05HA_2159	COG0549	Belongs to the carbamate kinase family
NT05HA_2160	COG1288	antiporter activity
NT05HA_2161	COG1522	sequence-specific DNA binding
NT05HA_2163	COG0051	transcription antitermination factor activity, RNA binding
NT05HA_2164	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NT05HA_2165	COG0088	Forms part of the polypeptide exit tunnel
NT05HA_2166	COG0089	rRNA binding
NT05HA_2167	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NT05HA_2168	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NT05HA_2169	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NT05HA_2170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NT05HA_2171	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NT05HA_2173	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NT05HA_2177	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NT05HA_2181	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NT05HA_2184	COG0201	protein transport
NT05HA_2187	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NT05HA_2190	COG0463	Glycosyl transferase, family 2
NT05HA_2191	COG1519	Transferase
NT05HA_2192	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NT05HA_2194	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NT05HA_2195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NT05HA_2196	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NT05HA_2200	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
NT05HA_2201	COG1466	dna polymerase III delta subunit
NT05HA_2203	COG0494	nUDIX hydrolase
NT05HA_2206	COG4701	Protein of unknown function (DUF721)
NT05HA_2207	COG0789	Transcriptional regulator
NT05HA_2208	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NT05HA_2215	COG0583	DNA-binding transcription factor activity
NT05HA_2225	COG3384	dioxygenase
NT05HA_2226	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NT05HA_2228	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NT05HA_2229	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NT05HA_2231	COG4796	Type ii and iii secretion system protein
NT05HA_2235	COG4972	Pilus assembly protein
NT05HA_2238	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NT05HA_2240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NT05HA_2245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NT05HA_2248	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NT05HA_2252	COG3306	glycosyltransferase involved in LPS biosynthesis
NT05HA_2254	COG3306	glycosyltransferase involved in LPS biosynthesis
NT05HA_2256	COG4750	Nucleotidyl transferase
NT05HA_2260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NT05HA_2261	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NT05HA_2262	COG1309	transcriptional regulator
NT05HA_2263	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT05HA_2264	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NT05HA_2265	COG0500	methyltransferase
NT05HA_2268	COG0762	integral membrane protein
NT05HA_2271	COG0778	Nitroreductase
NT05HA_2272	COG1368	sulfuric ester hydrolase activity
NT05HA_2277	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NT05HA_2280	COG0006	proline dipeptidase activity
NT05HA_2283	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT05HA_2287	COG0335	large ribosomal subunit rRNA binding
NT05HA_2288	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NT05HA_2289	COG1792	Involved in formation and maintenance of cell shape
NT05HA_2290	COG1077	Cell shape determining protein MreB Mrl
NT05HA_2292	COG0557	exoribonuclease II activity
NT05HA_2295	COG2271	Major facilitator Superfamily
NT05HA_2296	COG0584	glycerophosphoryl diester phosphodiesterase
NT05HA_2298	COG0583	DNA-binding transcription factor activity
NT05HA_2299	COG2962	Rard protein
NT05HA_2302	COG0551	DNA topoisomerase type I activity
NT05HA_2306	COG0705	Rhomboid family
NT05HA_2307	COG1349	DNA-binding transcription factor activity
NT05HA_2308	COG4206	TonB-dependent receptor
NT05HA_2308	COG1629	transport
NT05HA_2311	COG0582	viral genome integration into host DNA
NT05HA_2312	COG0582	viral genome integration into host DNA
NT05HA_2320	COG5566	PFAM Mor transcription activator
NT05HA_2322	COG0582	viral genome integration into host DNA
NT05HA_2324	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NT05HA_2326	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NT05HA_2328	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NT05HA_2332	COG3115	cell septum assembly
NT05HA_2334	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NT05HA_2336	COG1573	uracil-dna glycosylase
NT05HA_2337	COG0012	GTP binding
NT05HA_2338	COG0193	aminoacyl-tRNA hydrolase activity
NT05HA_2341	COG0560	Phosphoserine phosphatase
NT05HA_2344	COG0728	peptidoglycan biosynthetic process
NT05HA_2345	COG0196	riboflavin kinase activity
NT05HA_2350	COG1555	photosystem II stabilization
NT05HA_2351	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NT05HA_2353	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NT05HA_2354	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NT05HA_2355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NT05HA_2356	COG2321	neutral zinc metallopeptidase
NT05HA_2357	COG1652	LysM domain
NT05HA_2359	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NT05HA_2360	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
NT05HA_2362	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NT05HA_2365	COG0436	Aminotransferase
NT05HA_2367	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NT05HA_2368	COG2267	carboxylic ester hydrolase activity
NT05HA_2370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NT05HA_2371	COG3091	SprT-like family
NT05HA_2373	COG0814	amino acid
NT05HA_2374	COG1760	l-serine dehydratase