locus-tag	class	description
J5X96_00010	COG0592	DNA-directed DNA polymerase activity
J5X96_00020	COG2226	methyltransferase
J5X96_00030	COG2841	Protein conserved in bacteria
J5X96_00035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5X96_00040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5X96_00045	COG3036	rescue of stalled ribosome
J5X96_00055	COG4211	Belongs to the binding-protein-dependent transport system permease family
J5X96_00060	COG1129	ABC transporter
J5X96_00065	COG1879	ABC-type sugar transport system periplasmic component
J5X96_00070	COG1609	Transcriptional regulator
J5X96_00075	COG1085	galactose-1-phosphate uridylyltransferase
J5X96_00080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J5X96_00085	COG2017	converts alpha-aldose to the beta-anomer
J5X96_00090	COG1381	Involved in DNA repair and RecF pathway recombination
J5X96_00095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5X96_00100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5X96_00105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J5X96_00120	COG1230	cation diffusion facilitator family transporter
J5X96_00125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J5X96_00130	COG0303	'Molybdopterin
J5X96_00170	COG3005	denitrification pathway
J5X96_00175	COG3043	anaerobic respiration
J5X96_00180	COG0348	domain, Protein
J5X96_00185	COG0437	4 iron, 4 sulfur cluster binding
J5X96_00190	COG0243	molybdopterin cofactor binding
J5X96_00195	COG3062	negative regulation of establishment of protein localization
J5X96_00200	COG2267	carboxylic ester hydrolase activity
J5X96_00205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5X96_00210	COG0561	phosphatase activity
J5X96_00220	COG0028	Belongs to the TPP enzyme family
J5X96_00235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5X96_00240	COG1238	metal cluster binding
J5X96_00255	COG1943	Transposase
J5X96_00275	COG1724	mRNA binding
J5X96_00280	COG1598	PFAM Uncharacterised protein family UPF0150
J5X96_00325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5X96_00335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J5X96_00340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5X96_00365	COG0560	Phosphoserine phosphatase
J5X96_00385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5X96_00390	COG0561	phosphatase activity
J5X96_00395	COG1040	competence protein
J5X96_00415	COG0616	signal peptide processing
J5X96_00430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5X96_00435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5X96_00440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5X96_00440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J5X96_00445	COG0569	domain protein
J5X96_00455	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
J5X96_00480	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
J5X96_00485	COG1959	2 iron, 2 sulfur cluster binding
J5X96_00495	COG0822	iron-sulfur transferase activity
J5X96_00505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J5X96_00510	COG0443	Heat shock 70 kDa protein
J5X96_00515	COG0633	Ferredoxin
J5X96_00520	COG2975	iron-sulfur cluster assembly
J5X96_00525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5X96_00525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5X96_00530	COG0489	protein tyrosine kinase activity
J5X96_00535	COG0587	DNA-directed DNA polymerase activity
J5X96_00555	COG3111	PFAM Bacterial OB fold (BOF) protein
J5X96_00560	COG0745	RESPONSE REGULATOR receiver
J5X96_00565	COG0642	Histidine kinase
J5X96_00570	COG0346	lactoylglutathione lyase activity
J5X96_00580	COG2831	hemolysin activation secretion protein
J5X96_00585	COG3210	domain, Protein
J5X96_00625	COG2814	Major facilitator Superfamily
J5X96_00630	COG1763	Mo-molybdopterin cofactor biosynthetic process
J5X96_00635	COG2364	Membrane
J5X96_00640	COG0859	PFAM glycosyl transferase family 9
J5X96_00645	COG0786	glutamate:sodium symporter activity
J5X96_00650	COG2195	Cleaves the N-terminal amino acid of tripeptides
J5X96_00660	COG4942	peptidase
J5X96_00665	COG2861	carbohydrate metabolic process
J5X96_00670	COG0606	chelatase, subunit chli
J5X96_00680	COG2990	Protein conserved in bacteria
J5X96_00690	COG1285	pathogenesis
J5X96_00710	COG0754	glutathionylspermidine amidase activity
J5X96_00715	COG0789	Transcriptional regulator
J5X96_00720	COG4701	Protein of unknown function (DUF721)
J5X96_00735	COG0494	nUDIX hydrolase
J5X96_00760	COG0210	DNA helicase
J5X96_00765	COG5645	(Lipo)protein
J5X96_00775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5X96_00775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5X96_00790	COG2391	methyltransferase activity
J5X96_00795	COG0425	Belongs to the sulfur carrier protein TusA family
J5X96_00810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5X96_00820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5X96_00825	COG1349	DNA-binding transcription factor activity
J5X96_00830	COG0776	regulation of translation
J5X96_00835	COG3068	Protein conserved in bacteria
J5X96_00840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5X96_00865	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5X96_00885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5X96_00895	COG4771	TonB-dependent receptor
J5X96_00910	COG0494	nUDIX hydrolase
J5X96_00915	COG0730	response to heat
J5X96_00930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5X96_00935	COG1733	regulation of RNA biosynthetic process
J5X96_00940	COG0702	epimerase
J5X96_00965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J5X96_00970	COG0248	Ppx GppA phosphatase
J5X96_00975	COG2911	Protein conserved in bacteria
J5X96_00980	COG0729	surface antigen
J5X96_00985	COG2197	response regulator
J5X96_00995	COG0181	hydroxymethylbilane synthase activity
J5X96_01005	COG2959	enzyme of heme biosynthesis
J5X96_01010	COG3071	HemY protein
J5X96_01020	COG1519	Transferase
J5X96_01025	COG0463	Glycosyl transferase, family 2
J5X96_01030	COG0459	protein refolding
J5X96_01035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5X96_01040	COG3030	protein affecting phage T7 exclusion by the F plasmid
J5X96_01045	COG1027	Aspartate ammonia-lyase
J5X96_01060	COG2853	Lipoprotein
J5X96_01070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5X96_01075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5X96_01105	COG3312	ion transport
J5X96_01115	COG0445	tRNA wobble uridine modification
J5X96_01120	COG0716	FMN binding
J5X96_01125	COG3074	FtsZ-dependent cytokinesis
J5X96_01135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5X96_01160	COG1494	fructose-1,6-bisphosphatase
J5X96_01165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5X96_01180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5X96_01215	COG1466	dna polymerase III delta subunit
J5X96_01220	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
J5X96_01225	COG0433	COG0433 Predicted ATPase
J5X96_01230	COG2258	MOSC domain
J5X96_01235	COG3012	SEC-C Motif Domain Protein
J5X96_01245	COG1490	D-aminoacyl-tRNA deacylase activity
J5X96_01250	COG0762	integral membrane protein
J5X96_01470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5X96_01525	COG4695	Portal protein
J5X96_01530	COG0752	glycyl-tRNA synthetase alpha subunit
J5X96_01540	COG4545	Glutaredoxin-related protein
J5X96_01555	COG2852	Protein conserved in bacteria
J5X96_01565	COG0751	glycine-tRNA ligase activity
J5X96_01575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5X96_01580	COG1114	Component of the transport system for branched-chain amino acids
J5X96_01625	COG1477	protein flavinylation
J5X96_01635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5X96_01640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5X96_01645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J5X96_01650	COG3201	nicotinamide mononucleotide transporter
J5X96_01670	COG2991	Protein conserved in bacteria
J5X96_01715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5X96_01725	COG1309	transcriptional regulator
J5X96_01740	COG1072	(Pantothenic acid kinase))
J5X96_01770	COG0733	neurotransmitter:sodium symporter activity
J5X96_01780	COG2818	Glycosylase
J5X96_01785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J5X96_01790	COG1275	C4-dicarboxylate transporter malic acid transport protein
J5X96_01805	COG3850	Histidine kinase
J5X96_01810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5X96_01820	COG1739	Uncharacterized protein family UPF0029
J5X96_01825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5X96_01830	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
J5X96_01875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J5X96_01880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5X96_01895	COG1045	serine acetyltransferase
J5X96_01900	COG0251	oxidation-reduction process
J5X96_01910	COG1530	ribonuclease E activity
J5X96_01940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5X96_01945	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5X96_01955	COG3842	ATPase activity
J5X96_01965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
J5X96_01970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5X96_01980	COG1561	YicC-like family, N-terminal region
J5X96_01985	COG0354	folic acid binding
J5X96_01995	COG0051	transcription antitermination factor activity, RNA binding
J5X96_02000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5X96_02005	COG0088	Forms part of the polypeptide exit tunnel
J5X96_02010	COG0089	rRNA binding
J5X96_02015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5X96_02020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5X96_02025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5X96_02030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5X96_02035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5X96_02040	COG0255	Belongs to the universal ribosomal protein uL29 family
J5X96_02045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5X96_02070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5X96_02110	COG0201	protein transport
J5X96_02120	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5X96_02130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5X96_02150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
J5X96_02165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5X96_02170	COG1309	transcriptional regulator
J5X96_02175	COG0583	DNA-binding transcription factor activity
J5X96_02180	COG0678	peroxiredoxin activity
J5X96_02180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5X96_02185	COG2900	Belongs to the SlyX family
J5X96_02190	COG0545	Peptidyl-prolyl cis-trans isomerase
J5X96_02195	COG2964	Protein conserved in bacteria
J5X96_02200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J5X96_02210	COG2168	tRNA wobble position uridine thiolation
J5X96_02215	COG1126	abc transporter atp-binding protein
J5X96_02220	COG0765	amino acid transport
J5X96_02225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5X96_02230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5X96_02235	COG4988	ABC transporter
J5X96_02240	COG1132	(ABC) transporter
J5X96_02260	COG2268	Band 7 protein
J5X96_02270	COG0778	Nitroreductase
J5X96_02275	COG1368	sulfuric ester hydrolase activity
J5X96_02285	COG1595	DNA-templated transcription, initiation
J5X96_02300	COG2095	MarC family integral membrane protein
J5X96_02305	COG0488	(ABC) transporter
J5X96_02310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5X96_02315	COG2137	regulation of response to DNA damage stimulus
J5X96_02335	COG1595	DNA-templated transcription, initiation
J5X96_02340	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
J5X96_02345	COG3026	antisigma factor binding
J5X96_02350	COG3086	response to oxidative stress
J5X96_02360	COG1393	Belongs to the ArsC family
J5X96_02375	COG0142	geranyltranstransferase activity
J5X96_02380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J5X96_02395	COG2056	Na+-H+ antiporter family
J5X96_02400	COG4771	TonB-dependent receptor
J5X96_02410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5X96_02415	COG0084	hydrolase, TatD family'
J5X96_02430	COG0121	glutamine amidotransferase
J5X96_02440	COG0740	serine-type endopeptidase activity
J5X96_02445	COG2194	sulfuric ester hydrolase activity
J5X96_02450	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5X96_02450	COG2918	glutathione biosynthetic process
J5X96_02455	COG1399	metal-binding, possibly nucleic acid-binding protein
J5X96_02475	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5X96_02480	COG1028	Short-chain dehydrogenase reductase Sdr
J5X96_02490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5X96_02490	COG1328	CTP reductase activity
J5X96_02495	COG0602	queuosine metabolic process
J5X96_02505	COG1522	sequence-specific DNA binding
J5X96_02510	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
J5X96_02530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5X96_02535	COG2183	response to ionizing radiation
J5X96_02540	COG5413	integral membrane protein
J5X96_02550	COG0204	Acyl-transferase
J5X96_02560	COG3266	domain, Protein
J5X96_02565	COG4783	chaperone-mediated protein folding
J5X96_02570	COG3924	membrane
J5X96_02575	COG4145	pantothenate transmembrane transporter activity
J5X96_02580	COG2184	nucleotidyltransferase activity
J5X96_02590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5X96_02595	COG0494	nUDIX hydrolase
J5X96_02600	COG1840	ABC-type Fe3 transport system, periplasmic component
J5X96_02610	COG1022	Amp-dependent synthetase and ligase
J5X96_02625	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5X96_02640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5X96_02645	COG3172	ATPase kinase involved in NAD metabolism
J5X96_02650	COG2129	metallophosphoesterase
J5X96_02655	COG0814	amino acid
J5X96_02660	COG1388	LysM domain
J5X96_02660	COG4942	peptidase
J5X96_02670	COG1238	metal cluster binding
J5X96_02700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5X96_02715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5X96_02725	COG3115	cell septum assembly
J5X96_02750	COG0697	spore germination
J5X96_02760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J5X96_02765	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
J5X96_02775	COG0800	Aldolase
J5X96_02780	COG0659	secondary active sulfate transmembrane transporter activity
J5X96_02790	COG0754	glutathionylspermidine amidase activity
J5X96_02810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5X96_02810	COG0475	glutathione-regulated potassium exporter activity
J5X96_02815	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J5X96_02825	COG1509	lysine 2,3-aminomutase activity
J5X96_02830	COG3266	domain, Protein
J5X96_02830	COG3061	Opacity-associated protein A
J5X96_02840	COG0745	RESPONSE REGULATOR receiver
J5X96_02845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5X96_02860	COG4232	protein-disulfide reductase activity
J5X96_02865	COG2259	Doxx family
J5X96_02870	COG0436	Aminotransferase
J5X96_02880	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
J5X96_02885	COG2267	carboxylic ester hydrolase activity
J5X96_02895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
J5X96_02900	COG0513	Belongs to the DEAD box helicase family
J5X96_02905	COG4785	May be involved in cell division
J5X96_02915	COG2731	YhcH YjgK YiaL family protein
J5X96_02920	COG1301	dicarboxylic acid transport
J5X96_02935	COG1115	amino acid carrier protein
J5X96_02950	COG0237	dephospho-CoA kinase activity
J5X96_02950	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J5X96_02955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
J5X96_02960	COG1459	type II secretion system
J5X96_02965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J5X96_02970	COG4969	Belongs to the N-Me-Phe pilin family
J5X96_02975	COG3023	N-Acetylmuramoyl-L-alanine amidase
J5X96_02990	COG2814	Major facilitator Superfamily
J5X96_02995	COG4133	protoheme IX ABC transporter activity
J5X96_03000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5X96_03005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5X96_03010	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5X96_03020	COG1138	Cytochrome C-type biogenesis protein
J5X96_03050	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
J5X96_03055	COG0437	4 iron, 4 sulfur cluster binding
J5X96_03060	COG3301	Polysulphide reductase, NrfD
J5X96_03065	COG1138	Cytochrome C-type biogenesis protein
J5X96_03070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5X96_03075	COG3088	subunit of a heme lyase
J5X96_03075	COG4235	cytochrome complex assembly
J5X96_03080	COG2081	HI0933 family
J5X96_03085	COG0567	Dehydrogenase, E1 component
J5X96_03090	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5X96_03100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J5X96_03110	COG3219	Protein conserved in bacteria
J5X96_03115	COG3220	belongs to the UPF0276 family
J5X96_03125	COG2259	Doxx family
J5X96_03145	COG2116	formate transmembrane transporter activity
J5X96_03150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5X96_03155	COG4137	Cytochrome C assembly protein
J5X96_03160	COG4536	flavin adenine dinucleotide binding
J5X96_03165	COG1573	uracil-dna glycosylase
J5X96_03170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5X96_03185	COG2860	membrane
J5X96_03195	COG0527	aspartate kinase activity
J5X96_03200	COG0728	peptidoglycan biosynthetic process
J5X96_03210	COG2814	Major facilitator Superfamily
J5X96_03215	COG3078	GTPase activator activity
J5X96_03225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5X96_03250	COG0811	peptide transport
J5X96_03255	COG0848	biopolymer transport protein
J5X96_03265	COG0312	modulator of DNA gyrase
J5X96_03270	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J5X96_03280	COG0742	ribosomal rna small subunit methyltransferase
J5X96_03290	COG3085	chromosome segregation
J5X96_03295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5X96_03300	COG3084	Protein conserved in bacteria
J5X96_03305	COG0746	molybdenum cofactor guanylyltransferase activity
J5X96_03315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5X96_03315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5X96_03320	COG1105	Belongs to the carbohydrate kinase PfkB family
J5X96_03325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5X96_03325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5X96_03325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
J5X96_03335	COG2814	Major facilitator Superfamily
J5X96_03340	COG1566	PFAM secretion protein HlyD family protein
J5X96_03345	COG0783	Belongs to the Dps family
J5X96_03350	COG0688	phosphatidylethanolamine metabolic process
J5X96_03355	COG0545	Peptidyl-prolyl cis-trans isomerase
J5X96_03365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5X96_03395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5X96_03400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J5X96_03420	COG0551	DNA topoisomerase type I activity
J5X96_03435	COG2962	Rard protein
J5X96_03440	COG0583	DNA-binding transcription factor activity
J5X96_03450	COG0187	DNA topoisomerase II activity
J5X96_03455	COG0514	ATP-dependent DNA helicase (RecQ)
J5X96_03465	COG0019	diaminopimelate decarboxylase activity
J5X96_03470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
J5X96_03475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J5X96_03480	COG1011	Hydrolase
J5X96_03485	COG0494	nUDIX hydrolase
J5X96_03495	COG3059	membrane
J5X96_03500	COG1297	OPT oligopeptide transporter protein
J5X96_03510	COG1218	3'(2'),5'-bisphosphate nucleotidase
J5X96_03515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5X96_03520	COG0363	glucosamine-6-phosphate deaminase activity
J5X96_03540	COG1794	racemase activity, acting on amino acids and derivatives
J5X96_03560	COG1132	(ABC) transporter
J5X96_03570	COG1629	transport
J5X96_03570	COG4774	siderophore transport
J5X96_03580	COG0765	amino acid transport
J5X96_03585	COG0765	amino acid transport
J5X96_03590	COG1126	abc transporter atp-binding protein
J5X96_03595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5X96_03600	COG0737	Belongs to the 5'-nucleotidase family
J5X96_03605	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5X96_03615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5X96_03625	COG2233	PERMEase
J5X96_03630	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5X96_03640	COG2976	Protein conserved in bacteria
J5X96_03655	COG1426	Protein conserved in bacteria
J5X96_03660	COG3063	Type IV pilus biogenesis stability protein PilW
J5X96_03675	COG1053	succinate dehydrogenase
J5X96_03680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5X96_03690	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
J5X96_03705	COG0697	spore germination
J5X96_03710	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J5X96_03720	COG1882	Formate acetyltransferase
J5X96_03725	COG2116	formate transmembrane transporter activity
J5X96_03730	COG0537	adenosine 5'-monophosphoramidase activity
J5X96_03750	COG0494	nUDIX hydrolase
J5X96_03755	COG3171	Protein conserved in bacteria
J5X96_03765	COG1194	a g-specific adenine glycosylase
J5X96_03770	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
J5X96_03790	COG3056	Lipoprotein
J5X96_03795	COG0271	Belongs to the BolA IbaG family
J5X96_03810	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J5X96_03815	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J5X96_03820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
J5X96_03825	COG2871	sodium ion transport
J5X96_03830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5X96_03835	COG4106	trans-aconitate 2-methyltransferase activity
J5X96_03840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5X96_03855	COG0494	nUDIX hydrolase
J5X96_03865	COG0641	radical SAM
J5X96_03890	COG1271	oxidase subunit
J5X96_03895	COG1294	oxidase, subunit
J5X96_03905	COG0824	Thioesterase
J5X96_03910	COG0811	peptide transport
J5X96_03915	COG0848	biopolymer transport protein
J5X96_03920	COG3064	Membrane
J5X96_03955	COG0626	cystathionine gamma-synthase activity
J5X96_03960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5X96_03970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5X96_03975	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5X96_03980	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J5X96_03990	COG4991	sh3 domain protein
J5X96_03995	COG0306	phosphate transporter
J5X96_04000	COG1392	Phosphate transport regulator
J5X96_04005	COG3025	triphosphatase activity
J5X96_04010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J5X96_04015	COG0793	Belongs to the peptidase S41A family
J5X96_04025	COG2995	paraquat-inducible protein a
J5X96_04030	COG3008	intermembrane lipid transfer
J5X96_04040	COG3610	response to peptide
J5X96_04045	COG2966	Psort location CytoplasmicMembrane, score
J5X96_04055	COG0861	Integral membrane protein TerC family
J5X96_04065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5X96_04075	COG3691	Protein conserved in bacteria
J5X96_04080	COG0439	Biotin carboxylase
J5X96_04085	COG0511	ligase activity, forming carbon-carbon bonds
J5X96_04100	COG0500	methyltransferase
J5X96_04110	COG0795	lipopolysaccharide-transporting ATPase activity
J5X96_04115	COG0795	lipopolysaccharide-transporting ATPase activity
J5X96_04130	COG1522	sequence-specific DNA binding
J5X96_04135	COG0826	peptidase U32
J5X96_04145	COG3945	hemerythrin HHE cation binding domain
J5X96_04150	COG0343	queuine tRNA-ribosyltransferase activity
J5X96_04160	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
J5X96_04165	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5X96_04170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J5X96_04180	COG0309	Hydrogenase expression formation protein (HypE)
J5X96_04185	COG0409	Hydrogenase expression formation protein
J5X96_04190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J5X96_04195	COG1122	ATPase activity
J5X96_04200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J5X96_04205	COG0310	cobalt ion transport
J5X96_04210	COG0310	cobalt ion transport
J5X96_04215	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
J5X96_04220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J5X96_04225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5X96_04230	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5X96_04235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5X96_04250	COG1522	sequence-specific DNA binding
J5X96_04255	COG1288	antiporter activity
J5X96_04260	COG0549	Belongs to the carbamate kinase family
J5X96_04265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5X96_04270	COG0038	chloride channel
J5X96_04285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5X96_04290	COG0628	permease
J5X96_04295	COG0347	Belongs to the P(II) protein family
J5X96_04300	COG0006	proline dipeptidase activity
J5X96_04320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5X96_04335	COG1496	oxidoreductase activity
J5X96_04340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5X96_04345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J5X96_04355	COG1368	sulfuric ester hydrolase activity
J5X96_04365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5X96_04375	COG0741	lytic transglycosylase activity
J5X96_04420	COG2920	part of a sulfur-relay system
J5X96_04430	COG1121	(ABC) transporter
J5X96_04435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5X96_04440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5X96_04445	COG2814	Major facilitator Superfamily
J5X96_04465	COG3304	Inner membrane component domain
J5X96_04470	COG1289	transmembrane transporter activity
J5X96_04485	COG1621	beta-fructofuranosidase activity
J5X96_04490	COG0733	neurotransmitter:sodium symporter activity
J5X96_04495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5X96_04515	COG4656	Part of a membrane complex involved in electron transport
J5X96_04525	COG4657	Part of a membrane complex involved in electron transport
J5X96_04530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J5X96_04545	COG0732	type I restriction modification DNA specificity domain
J5X96_04550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
J5X96_04555	COG0307	riboflavin synthase, alpha
J5X96_04565	COG4774	siderophore transport
J5X96_04570	COG4178	(ABC) transporter
J5X96_04595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5X96_04600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5X96_04605	COG2190	(PTS) system
J5X96_04615	COG3102	Protein conserved in bacteria
J5X96_04620	COG3133	Outer membrane lipoprotein
J5X96_04625	COG1534	Rna-binding protein
J5X96_04635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5X96_04640	COG0577	efflux transmembrane transporter activity
J5X96_04640	COG1136	(ABC) transporter
J5X96_04650	COG0577	efflux transmembrane transporter activity
J5X96_04665	COG0672	)-iron permease
J5X96_04670	COG1556	Lactate utilization protein
J5X96_04675	COG1139	Iron-sulfur cluster binding protein
J5X96_04680	COG0247	lactate metabolic process
J5X96_04685	COG1620	l-lactate permease
J5X96_04690	COG0277	FAD linked oxidase domain protein
J5X96_04695	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
J5X96_04710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5X96_04720	COG2062	phosphohistidine phosphatase, SixA
J5X96_04735	COG0814	amino acid
J5X96_04750	COG2814	Major facilitator Superfamily
J5X96_04755	COG0375	protein maturation
J5X96_04760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5X96_04765	COG3152	Membrane
J5X96_04770	COG2252	PERMEase
J5X96_04780	COG0825	malonyl-CoA metabolic process
J5X96_04820	COG0671	phosphoesterase, PA-phosphatase related
J5X96_04825	COG1940	carbohydrate kinase activity
J5X96_04830	COG1966	Carbon starvation protein
J5X96_04850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5X96_04855	COG1530	ribonuclease E activity
J5X96_04865	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
J5X96_04870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5X96_04920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5X96_04925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5X96_04930	COG0470	DNA polymerase III
J5X96_04935	COG0084	hydrolase, TatD family'
J5X96_04965	COG1840	ABC-type Fe3 transport system, periplasmic component
J5X96_04970	COG1840	ABC-type Fe3 transport system, periplasmic component
J5X96_04980	COG3842	ATPase activity
J5X96_04995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5X96_05000	COG0513	Belongs to the DEAD box helicase family
J5X96_05005	COG0799	negative regulation of ribosome biogenesis
J5X96_05020	COG0772	Belongs to the SEDS family
J5X96_05025	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5X96_05025	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5X96_05030	COG1686	Belongs to the peptidase S11 family
J5X96_05040	COG1660	Displays ATPase and GTPase activities
J5X96_05045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5X96_05050	COG1137	ATPase activity
J5X96_05055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J5X96_05060	COG3117	lipopolysaccharide transmembrane transporter activity
J5X96_05065	COG1127	ABC transporter
J5X96_05070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J5X96_05075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J5X96_05080	COG2854	intermembrane phospholipid transfer
J5X96_05085	COG3113	response to antibiotic
J5X96_05090	COG5007	Belongs to the BolA IbaG family
J5X96_05110	COG0681	Belongs to the peptidase S26 family
J5X96_05130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5X96_05135	COG0583	DNA-binding transcription factor activity
J5X96_05200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5X96_05215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J5X96_05230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5X96_05245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J5X96_05260	COG0437	4 iron, 4 sulfur cluster binding
J5X96_05265	COG2864	formate dehydrogenase
J5X96_05270	COG1560	Kdo2-lipid A biosynthetic process
J5X96_05275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
J5X96_05275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
J5X96_05280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5X96_05290	COG0512	Glutamine amidotransferase of anthranilate synthase
J5X96_05295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5X96_05300	COG4206	TonB-dependent receptor
J5X96_05330	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5X96_05335	COG3381	protein complex oligomerization
J5X96_05345	COG3100	YcgL domain-containing protein
J5X96_05350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5X96_05355	COG3112	Uncharacterised protein family (UPF0231)
J5X96_05360	COG0316	Belongs to the HesB IscA family
J5X96_05365	COG0024	Methionine aminopeptidase
J5X96_05380	COG2801	Transposase and inactivated derivatives
J5X96_05385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5X96_05390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5X96_05395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
J5X96_05400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5X96_05470	COG1518	maintenance of DNA repeat elements
J5X96_05475	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J5X96_05480	COG2233	PERMEase
J5X96_05485	COG3069	C4-dicarboxylate transmembrane transporter activity
J5X96_05490	COG0339	signal peptide processing
J5X96_05495	COG2832	Protein of unknown function (DUF454)
J5X96_05500	COG4166	transmembrane transport
J5X96_05515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5X96_05520	COG0210	DNA helicase
J5X96_05525	COG0328	RNA-DNA hybrid ribonuclease activity
J5X96_05530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5X96_05580	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5X96_05595	COG2027	D-alanyl-D-alanine carboxypeptidase
J5X96_05600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5X96_05605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5X96_05610	COG2890	protein-(glutamine-N5) methyltransferase activity
J5X96_05620	COG0791	NLP P60 protein
J5X96_05625	COG1090	epimerase
J5X96_05630	COG1438	arginine binding
J5X96_05635	COG0322	excinuclease ABC activity
J5X96_05650	COG1663	tetraacyldisaccharide 4'-kinase activity
J5X96_05655	COG1132	(ABC) transporter
J5X96_05660	COG2333	competence protein COMEC
J5X96_05660	COG0658	competence protein
J5X96_05665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5X96_05670	COG0617	tRNA 3'-terminal CCA addition
J5X96_05675	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5X96_05680	COG2823	Periplasmic or secreted lipoprotein
J5X96_05685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
J5X96_05700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J5X96_05705	COG4172	Belongs to the ABC transporter superfamily
J5X96_05710	COG4172	Belongs to the ABC transporter superfamily
J5X96_05715	COG4171	peptide transport system, permease
J5X96_05720	COG4168	peptide transport system, permease
J5X96_05725	COG4166	transmembrane transport
J5X96_05730	COG0288	reversible hydration of carbon dioxide
J5X96_05740	COG2431	L-lysine efflux transmembrane transporter activity
J5X96_05745	COG0564	pseudouridine synthase activity
J5X96_05755	COG2824	Alkylphosphonate utilization operon protein PhnA
J5X96_05770	COG2337	Toxic component of a toxin-antitoxin (TA) module
J5X96_05780	COG0298	carbon dioxide binding
J5X96_05785	COG1773	rubredoxin
J5X96_05790	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
J5X96_05795	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
J5X96_05800	COG5557	Pfam Polysulphide reductase, NrfD
J5X96_05805	COG0437	4 iron, 4 sulfur cluster binding
J5X96_05810	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
J5X96_05820	COG0135	phosphoribosylanthranilate isomerase activity
J5X96_05820	COG0134	indole-3-glycerol-phosphate synthase activity
J5X96_05830	COG1942	4-Oxalocrotonate Tautomerase
J5X96_05835	COG0512	Glutamine amidotransferase of anthranilate synthase
J5X96_05840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5X96_05845	COG0633	Ferredoxin
J5X96_05860	COG0315	cyclic pyranopterin monophosphate synthase activity
J5X96_05865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
J5X96_05870	COG0314	molybdopterin synthase activity
J5X96_05880	COG2969	positive regulation of protein catabolic process
J5X96_05885	COG3842	ATPase activity
J5X96_05895	COG1840	ABC-type Fe3 transport system, periplasmic component
J5X96_05905	COG0626	cystathionine gamma-synthase activity
J5X96_05910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5X96_05915	COG2166	iron-sulfur cluster assembly
J5X96_05920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5X96_05925	COG1525	nuclease
J5X96_05930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5X96_05945	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
J5X96_05950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
J5X96_05955	COG0515	serine threonine protein kinase
J5X96_05960	COG2833	Protein of unknown function (DUF455)
J5X96_05965	COG1946	Acyl-CoA thioesterase
J5X96_05975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
J5X96_05980	COG4988	ABC transporter
J5X96_05985	COG0492	ferredoxin-NADP+ reductase activity
J5X96_05990	COG3118	belongs to the thioredoxin family
J5X96_06000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J5X96_06005	COG2801	Transposase and inactivated derivatives
J5X96_06055	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5X96_06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5X96_06075	COG0640	Transcriptional regulator
J5X96_06110	COG2207	Transcriptional regulator
J5X96_06120	COG0517	IMP dehydrogenase activity
J5X96_06120	COG1125	glycine betaine transport
J5X96_06125	COG1174	glycine betaine transport
J5X96_06135	COG3384	dioxygenase
J5X96_06140	COG2076	Multidrug Resistance protein
J5X96_06145	COG0753	catalase activity
J5X96_06155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5X96_06160	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J5X96_06165	COG0330	HflC and HflK could
J5X96_06170	COG0330	HflC and HflK could
J5X96_06180	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J5X96_06190	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J5X96_06195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J5X96_06200	COG1280	lysine exporter protein (LysE YggA)
J5X96_06210	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J5X96_06215	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J5X96_06215	COG0517	IMP dehydrogenase activity
J5X96_06235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5X96_06250	COG0791	NLP P60 protein
J5X96_06260	COG1686	Belongs to the peptidase S11 family
J5X96_06275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J5X96_06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5X96_06300	COG0785	Cytochrome C biogenesis protein
J5X96_06305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5X96_06305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5X96_06315	COG1346	cytolysis
J5X96_06325	COG0697	spore germination
J5X96_06330	COG2925	Exonuclease
J5X96_06335	COG1528	Iron-storage protein
J5X96_06340	COG1528	Iron-storage protein
J5X96_06345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5X96_06350	COG0583	DNA-binding transcription factor activity
J5X96_06355	COG0613	PHP domain protein
J5X96_06370	COG0308	aminopeptidase N
J5X96_06375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5X96_06380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5X96_06385	COG1448	Aminotransferase
J5X96_06435	COG0318	PFAM AMP-dependent synthetase and ligase
J5X96_06440	COG3065	identical protein binding
J5X96_06445	COG1214	PFAM Peptidase M22, glycoprotease
J5X96_06450	COG1199	ATP-dependent helicase activity
J5X96_06455	COG0676	glucose-6-phosphate 1-epimerase activity
J5X96_06470	COG2962	Rard protein
J5X96_06475	COG1522	sequence-specific DNA binding
J5X96_06480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5X96_06485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5X96_06490	COG0589	response to stress
J5X96_06495	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
J5X96_06500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5X96_06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5X96_06510	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
J5X96_06520	COG3955	Domain of unknown function (DUF1919)
J5X96_06525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5X96_06530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J5X96_06530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5X96_06540	COG0058	SHG alpha-glucan phosphorylase activity
J5X96_06555	COG1523	belongs to the glycosyl hydrolase 13 family
J5X96_06570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5X96_06575	COG1067	ATP-dependent peptidase activity
J5X96_06590	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
J5X96_06595	COG3098	single-species biofilm formation
J5X96_06600	COG0564	pseudouridine synthase activity
J5X96_06610	COG1278	Cold shock
J5X96_06625	COG1518	maintenance of DNA repeat elements
J5X96_06685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5X96_06690	COG0586	Pfam SNARE associated Golgi protein
J5X96_06695	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5X96_06715	COG0469	pyruvate kinase activity
J5X96_06720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J5X96_06725	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J5X96_06745	COG3630	sodium ion export across plasma membrane
J5X96_06750	COG0511	ligase activity, forming carbon-carbon bonds
J5X96_06750	COG5016	pyruvate
J5X96_06760	COG0802	atpase or kinase
J5X96_06765	COG1388	LysM domain
J5X96_06765	COG0860	N-Acetylmuramoyl-L-alanine amidase
J5X96_06770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J5X96_06780	COG1923	regulation of RNA biosynthetic process
J5X96_06785	COG3283	Transcriptional regulator of aromatic amino acids metabolism
J5X96_06795	COG3106	COG3106 Predicted ATPase
J5X96_06810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5X96_06815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5X96_06825	COG2949	membrane
J5X96_06830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5X96_06840	COG3101	peptidyl-lysine hydroxylation
J5X96_06845	COG3099	Belongs to the UPF0263 family
J5X96_06855	COG0285	dihydrofolate synthase activity
J5X96_06870	COG2801	Transposase and inactivated derivatives
J5X96_06890	COG2801	Transposase and inactivated derivatives
J5X96_06895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5X96_06905	COG2819	hydrolase of the alpha beta superfamily
J5X96_06910	COG1253	flavin adenine dinucleotide binding
J5X96_06915	COG1252	NADH dehydrogenase
J5X96_06980	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
J5X96_06985	COG0708	Exodeoxyribonuclease III
J5X96_06990	COG2951	lytic endotransglycosylase activity
J5X96_06995	COG1216	Glycosyl transferase, family 2
J5X96_07000	COG1216	Glycosyl transferase, family 2
J5X96_07010	COG3306	glycosyltransferase involved in LPS biosynthesis
J5X96_07020	COG5039	Polysaccharide pyruvyl transferase
J5X96_07025	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J5X96_07030	COG1793	dna ligase
J5X96_07050	COG2315	Protein conserved in bacteria
J5X96_07055	COG0471	metal ion transport
J5X96_07060	COG0101	tRNA pseudouridine synthase activity
J5X96_07075	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5X96_07080	COG1074	ATP-dependent DNA helicase activity
J5X96_07090	COG2252	PERMEase
J5X96_07100	COG0402	S-adenosylhomocysteine deaminase activity
J5X96_07105	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J5X96_07130	COG2321	neutral zinc metallopeptidase
J5X96_07135	COG1652	LysM domain
J5X96_07145	COG0583	DNA-binding transcription factor activity
J5X96_07155	COG0009	L-threonylcarbamoyladenylate synthase
J5X96_07160	COG0616	signal peptide processing
J5X96_07165	COG0778	Nitroreductase
J5X96_07175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5X96_07180	COG0640	Transcriptional regulator
J5X96_07190	COG1286	toxin biosynthetic process
J5X96_07200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5X96_07205	COG0280	phosphate acetyltransferase
J5X96_07205	COG0857	belongs to the CobB CobQ family
J5X96_07210	COG2271	Major facilitator Superfamily
J5X96_07215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
J5X96_07225	COG0247	lactate metabolic process
J5X96_07230	COG1288	antiporter activity
J5X96_07240	COG0195	Participates in both transcription termination and antitermination
J5X96_07260	COG3041	Addiction module toxin RelE StbE family
J5X96_07270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5X96_07275	COG0577	efflux transmembrane transporter activity
J5X96_07275	COG1136	(ABC) transporter
J5X96_07280	COG1538	Outer membrane efflux protein
J5X96_07285	COG0488	(ABC) transporter
J5X96_07300	COG2932	Transcriptional regulator
J5X96_07305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5X96_07315	COG0788	formyltetrahydrofolate deformylase activity
J5X96_07320	COG2916	Histone family protein nucleoid-structuring protein H-NS
J5X96_07325	COG1757	Na H antiporter
J5X96_07330	COG0028	Belongs to the TPP enzyme family
J5X96_07335	COG0440	acetolactate synthase activity
J5X96_07340	COG2194	sulfuric ester hydrolase activity
J5X96_07350	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J5X96_07355	COG4221	oxidoreductase activity
J5X96_07365	COG0133	tryptophan synthase activity
J5X96_07375	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J5X96_07375	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J5X96_07385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5X96_07390	COG0583	DNA-binding transcription factor activity
J5X96_07400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5X96_07405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5X96_07405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5X96_07410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5X96_07445	COG2005	Transcriptional regulator
J5X96_07450	COG0725	ABC transporter, periplasmic molybdate-binding protein
J5X96_07455	COG4149	molybdate abc transporter
J5X96_07460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J5X96_07490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5X96_07495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5X96_07500	COG3094	Invasion gene expression up-regulator, SirB
J5X96_07515	COG0305	Participates in initiation and elongation during chromosome replication
J5X96_07520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J5X96_07525	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5X96_07530	COG1136	(ABC) transporter
J5X96_07535	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5X96_07540	COG0646	methionine synthase
J5X96_07540	COG1410	methionine synthase
J5X96_07570	COG3210	domain, Protein
J5X96_07580	COG3210	domain, Protein
J5X96_07590	COG3210	domain, Protein
J5X96_07595	COG0385	Bile acid
J5X96_07600	COG0187	DNA topoisomerase II activity
J5X96_07605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5X96_07615	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
J5X96_07625	COG0251	oxidation-reduction process
J5X96_07630	COG3021	interspecies interaction between organisms
J5X96_07635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5X96_07645	COG1560	Kdo2-lipid A biosynthetic process
J5X96_07650	COG0730	response to heat
J5X96_07655	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
J5X96_07665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J5X96_07665	COG3264	Mechanosensitive ion channel
J5X96_07670	COG0318	PFAM AMP-dependent synthetase and ligase
J5X96_07675	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
J5X96_07680	COG0596	Alpha beta hydrolase
J5X96_07690	COG0716	FMN binding
J5X96_07695	COG0735	belongs to the Fur family
J5X96_07735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
J5X96_07740	COG1177	transmembrane transport
J5X96_07745	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5X96_07750	COG3842	ATPase activity
J5X96_07810	COG4535	Mg2 and Co2 transporter CorC
J5X96_07815	COG0739	heme binding
J5X96_07825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5X96_07830	COG2165	general secretion pathway protein
J5X96_07835	COG4795	General secretion pathway protein
J5X96_07850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J5X96_07855	COG0456	acetyltransferase
J5X96_07860	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
J5X96_07865	COG2813	Specifically methylates the guanine in position
J5X96_07880	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
J5X96_07890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5X96_07895	COG0849	cell division
J5X96_07900	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J5X96_07925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5X96_07935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5X96_07940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5X96_07945	COG0768	penicillin binding
J5X96_07950	COG3116	cell division
J5X96_07965	COG3091	SprT-like family
J5X96_07970	COG1760	l-serine dehydratase
J5X96_07975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J5X96_07980	COG1126	abc transporter atp-binding protein
J5X96_07985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5X96_07990	COG4215	(ABC) transporter
J5X96_07995	COG4160	amino acid transport
J5X96_08000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5X96_08005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5X96_08010	COG1862	Preprotein translocase
J5X96_08015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5X96_08020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5X96_08025	COG1309	transcriptional regulator
J5X96_08030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J5X96_08040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5X96_08050	COG0583	DNA-binding transcription factor activity
J5X96_08055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
J5X96_08060	COG1687	branched-chain amino acid
J5X96_08070	COG2363	Small membrane protein
J5X96_08075	COG1643	Atp-dependent helicase
J5X96_08105	COG2990	Protein conserved in bacteria
J5X96_08110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5X96_08115	COG0539	negative regulation of cytoplasmic translation
J5X96_08120	COG0776	regulation of translation
J5X96_08125	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
J5X96_08130	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
J5X96_08140	COG0023	Translation Initiation Factor
J5X96_08145	COG1263	PTS System
J5X96_08145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5X96_08145	COG2190	(PTS) system
J5X96_08155	COG0058	SHG alpha-glucan phosphorylase activity
J5X96_08160	COG2188	Transcriptional regulator
J5X96_08165	COG0497	DNA recombination
J5X96_08175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5X96_08185	COG3070	regulator of competence-specific genes
J5X96_08195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5X96_08200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5X96_08205	COG0488	(ABC) transporter
J5X96_08215	COG3683	transport system, periplasmic component
J5X96_08230	COG1607	acyl-coa hydrolase
J5X96_08235	COG2350	Protein conserved in bacteria
J5X96_08240	COG1555	photosystem II stabilization
J5X96_08245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5X96_08255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5X96_08260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J5X96_08265	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5X96_08270	COG2268	Band 7 protein
J5X96_08275	COG0114	fumarate hydratase activity
J5X96_08280	COG2927	DNA polymerase III (CHI subunit)
J5X96_08305	COG1876	peptidase activity
J5X96_08315	COG1393	Belongs to the ArsC family
J5X96_08320	COG1476	TRANSCRIPTIONal
J5X96_08330	COG0326	Molecular chaperone. Has ATPase activity
J5X96_08335	COG0758	DNA mediated transformation
J5X96_08340	COG2091	lysine biosynthetic process via aminoadipic acid
J5X96_08345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5X96_08355	COG0460	homoserine dehydrogenase
J5X96_08355	COG0527	aspartate kinase activity
J5X96_08360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J5X96_08365	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5X96_08375	COG1758	RNA polymerase activity
J5X96_08380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5X96_08390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5X96_08395	COG0077	Prephenate dehydratase
J5X96_08395	COG1605	Chorismate mutase
J5X96_08440	COG4964	Belongs to the GSP D family
J5X96_08465	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5X96_08470	COG1444	tRNA N-acetyltransferase activity
J5X96_08490	COG2850	peptidyl-arginine hydroxylation
J5X96_08520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5X96_08530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J5X96_08535	COG1408	metallophosphoesterase
J5X96_08540	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
J5X96_08545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5X96_08550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5X96_08555	COG1120	ATPase activity
J5X96_08560	COG4607	ABC-type enterochelin transport system periplasmic component
J5X96_08565	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5X96_08570	COG4605	iron ion homeostasis
J5X96_08575	COG4604	ABC transporter, ATP-binding protein
J5X96_08580	COG3105	Protein conserved in bacteria
J5X96_08585	COG0784	Response regulator, receiver
J5X96_08585	COG2198	Histidine kinase
J5X96_08585	COG5002	protein histidine kinase activity
J5X96_08595	COG0142	geranyltranstransferase activity
J5X96_08605	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
J5X96_08610	COG1858	cytochrome C peroxidase
J5X96_08620	COG0557	exoribonuclease II activity
J5X96_08635	COG0233	cytoplasmic translational termination
J5X96_08650	COG0575	Belongs to the CDS family
J5X96_08665	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
J5X96_08675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5X96_08695	COG0471	metal ion transport
J5X96_08695	COG0490	domain, Protein
J5X96_08700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5X96_08710	COG4589	Belongs to the CDS family
J5X96_08715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5X96_08720	COG0456	acetyltransferase
J5X96_08725	COG0149	triose-phosphate isomerase activity
J5X96_08745	COG0705	Rhomboid family
J5X96_08750	COG1349	DNA-binding transcription factor activity
J5X96_08755	COG2177	Part of the ABC transporter FtsEX involved in
J5X96_08760	COG2884	Cell division ATP-binding protein ftsE
J5X96_08765	COG0552	protein localization to endoplasmic reticulum
J5X96_08770	COG0742	ribosomal rna small subunit methyltransferase
J5X96_08775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
J5X96_08780	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J5X96_08785	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
J5X96_08790	COG0471	metal ion transport
J5X96_08800	COG1575	Belongs to the MenA family. Type 1 subfamily
J5X96_08805	COG1720	tRNA m6t6A37 methyltransferase activity
J5X96_08810	COG0789	Transcriptional regulator
J5X96_08815	COG2608	mercury ion transmembrane transporter activity
J5X96_08820	COG2217	Heavy metal translocating P-type atpase
J5X96_08830	COG0105	UTP biosynthetic process
J5X96_08840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5X96_08855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J5X96_08860	COG1792	Involved in formation and maintenance of cell shape
J5X96_08865	COG1077	Cell shape determining protein MreB Mrl
J5X96_08870	COG4178	(ABC) transporter
J5X96_08890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5X96_08895	COG0066	3-isopropylmalate dehydratase activity
J5X96_08900	COG2226	methyltransferase
J5X96_08905	COG0814	amino acid
J5X96_08915	COG4783	chaperone-mediated protein folding
J5X96_08920	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5X96_08925	COG0590	tRNA wobble adenosine to inosine editing
J5X96_08935	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5X96_08945	COG0805	protein transport
J5X96_08955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5X96_08965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
J5X96_08970	COG0425	Belongs to the sulfur carrier protein TusA family
J5X96_08975	COG2391	methyltransferase activity
J5X96_08985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5X96_09000	COG5339	Protein conserved in bacteria
J5X96_09005	COG0443	Heat shock 70 kDa protein
J5X96_09020	COG0484	heat shock protein binding
J5X96_09025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5X96_09035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5X96_09040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5X96_09045	COG1944	ATP diphosphatase activity
J5X96_09055	COG3422	double-strand break repair
J5X96_09075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J5X96_09085	COG1704	LemA family
J5X96_09095	COG0247	lactate metabolic process
J5X96_09095	COG0277	FAD linked oxidase domain protein
J5X96_09105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5X96_09115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5X96_09120	COG0363	glucosamine-6-phosphate deaminase activity
J5X96_09125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5X96_09130	COG1737	Transcriptional regulator
J5X96_09140	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J5X96_09145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5X96_09150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5X96_09150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J5X96_09160	COG2190	(PTS) system
J5X96_09160	COG1263	PTS System
J5X96_09160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5X96_09165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5X96_09170	COG1917	Cupin 2, conserved barrel domain protein
J5X96_09170	COG4977	sequence-specific DNA binding
J5X96_09175	COG1132	(ABC) transporter
J5X96_09180	COG0402	S-adenosylhomocysteine deaminase activity
J5X96_09185	COG3083	sulfuric ester hydrolase activity
J5X96_09200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5X96_09205	COG0745	RESPONSE REGULATOR receiver
J5X96_09210	COG2205	protein histidine kinase activity
J5X96_09215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5X96_09235	COG0589	response to stress
J5X96_09260	COG0351	phosphomethylpyrimidine kinase
J5X96_09265	COG4143	(ABC) transporter
J5X96_09270	COG1178	ABC-type Fe3 transport system permease component
J5X96_09275	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J5X96_09295	COG1217	gtp-binding protein TYPA
J5X96_09300	COG0174	glutamine synthetase
J5X96_09310	COG1178	ABC-type Fe3 transport system permease component
J5X96_09315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J5X96_09325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5X96_09330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5X96_09335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5X96_09340	COG3719	Belongs to the RNase T2 family
J5X96_09350	COG0191	fructose-bisphosphate aldolase activity
J5X96_09355	COG3307	-O-antigen
J5X96_09370	COG0513	Belongs to the DEAD box helicase family
J5X96_09375	COG0138	bifunctional purine biosynthesis protein purh
J5X96_09380	COG0151	Belongs to the GarS family
J5X96_09395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5X96_09405	COG0012	GTP binding
J5X96_09410	COG0193	aminoacyl-tRNA hydrolase activity
J5X96_09420	COG2989	Protein conserved in bacteria
J5X96_09425	COG3108	Peptidase M15
J5X96_09430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5X96_09435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J5X96_09440	COG2814	Major facilitator Superfamily
J5X96_09445	COG4974	Belongs to the 'phage' integrase family
J5X96_09455	COG2226	methyltransferase
J5X96_09470	COG1846	Transcriptional regulator
J5X96_09470	COG1940	carbohydrate kinase activity
J5X96_09475	COG1840	ABC-type Fe3 transport system, periplasmic component
J5X96_09480	COG0859	PFAM glycosyl transferase family 9
J5X96_09485	COG3956	TIGRFAM MazG family protein
J5X96_09495	COG1349	DNA-binding transcription factor activity
J5X96_09500	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
J5X96_09505	COG1070	Carbohydrate kinase
J5X96_09510	COG4154	Belongs to the RbsD FucU family
J5X96_09515	COG0235	Class ii aldolase
J5X96_09520	COG1129	ABC transporter
J5X96_09525	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5X96_09530	COG1879	ABC-type sugar transport system periplasmic component
J5X96_09535	COG0280	phosphate acetyltransferase
J5X96_09535	COG0281	malic enzyme
J5X96_09545	COG0196	riboflavin kinase activity
J5X96_09565	COG0859	PFAM glycosyl transferase family 9
J5X96_09580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5X96_09590	COG0442	prolyl-tRNA aminoacylation
J5X96_09595	COG1921	L-seryl-tRNASec selenium transferase activity
J5X96_09600	COG3276	selenocysteine insertion sequence binding
J5X96_09605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
J5X96_09615	COG4796	Type ii and iii secretion system protein
J5X96_09635	COG4972	Pilus assembly protein
J5X96_09640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5X96_09645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J5X96_09650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5X96_09665	COG3028	Belongs to the UPF0307 family