locus-tag	class	description
FGM00_00005	COG2177	Part of the ABC transporter FtsEX involved in
FGM00_00010	COG0495	leucyl-tRNA aminoacylation
FGM00_00015	COG0686	Belongs to the AlaDH PNT family
FGM00_00030	COG1595	DNA-templated transcription, initiation
FGM00_00035	COG0384	phenazine biosynthesis protein PhzF
FGM00_00040	COG1522	sequence-specific DNA binding
FGM00_00050	COG2363	Small membrane protein
FGM00_00055	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FGM00_00075	COG0463	Glycosyl transferase, family 2
FGM00_00080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FGM00_00090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FGM00_00095	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FGM00_00120	COG0745	RESPONSE REGULATOR receiver
FGM00_00125	COG5002	protein histidine kinase activity
FGM00_00130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FGM00_00145	COG0489	protein tyrosine kinase activity
FGM00_00155	COG0492	ferredoxin-NADP+ reductase activity
FGM00_00160	COG0633	Ferredoxin
FGM00_00165	COG1132	(ABC) transporter
FGM00_00200	COG2610	gluconate transmembrane transporter activity
FGM00_00205	COG2205	protein histidine kinase activity
FGM00_00250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FGM00_00300	COG1070	Carbohydrate kinase
FGM00_00355	COG4206	TonB-dependent receptor
FGM00_00355	COG1629	transport
FGM00_00365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FGM00_00370	COG1554	hydrolase, family 65, central catalytic
FGM00_00385	COG2081	HI0933 family
FGM00_00420	COG1187	pseudouridine synthase activity
FGM00_00460	COG0165	Argininosuccinate lyase
FGM00_00470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FGM00_00475	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FGM00_00500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FGM00_00505	COG0137	argininosuccinate synthase activity
FGM00_00525	COG1215	transferase activity, transferring glycosyl groups
FGM00_00530	COG0463	Glycosyl transferase, family 2
FGM00_00540	COG2827	Endonuclease containing a URI domain
FGM00_00550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FGM00_00585	COG0189	ligase activity
FGM00_00595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FGM00_00595	COG2010	Cytochrome c
FGM00_00625	COG0439	Biotin carboxylase
FGM00_00630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FGM00_00635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FGM00_00640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FGM00_00640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FGM00_00645	COG0463	Glycosyl transferase, family 2
FGM00_00650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FGM00_00660	COG1054	Belongs to the UPF0176 family
FGM00_00665	COG1621	beta-fructofuranosidase activity
FGM00_00695	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FGM00_00725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FGM00_00740	COG2442	InterPro IPR007367
FGM00_00750	COG0823	Involved in the tonB-independent uptake of proteins
FGM00_00750	COG1506	peptidase
FGM00_00760	COG2333	competence protein COMEC
FGM00_00760	COG0658	competence protein
FGM00_00765	COG0791	NLP P60 protein
FGM00_00775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FGM00_00785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FGM00_00790	COG0793	Belongs to the peptidase S41A family
FGM00_00810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGM00_00815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGM00_00825	COG0772	Belongs to the SEDS family
FGM00_00845	COG1077	Cell shape determining protein MreB Mrl
FGM00_00850	COG0138	bifunctional purine biosynthesis protein purh
FGM00_00870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FGM00_00885	COG0701	Predicted permease
FGM00_00895	COG2217	Heavy metal translocating P-type atpase
FGM00_00900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FGM00_00945	COG0459	protein refolding
FGM00_00950	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FGM00_00975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FGM00_01000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FGM00_01030	COG0488	(ABC) transporter
FGM00_01070	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FGM00_01105	COG0110	maltose O-acetyltransferase activity
FGM00_01120	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FGM00_01135	COG0175	sulfate reduction
FGM00_01140	COG0529	Catalyzes the synthesis of activated sulfate
FGM00_01180	COG0438	transferase activity, transferring glycosyl groups
FGM00_01200	COG1215	transferase activity, transferring glycosyl groups
FGM00_01210	COG0110	maltose O-acetyltransferase activity
FGM00_01240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGM00_01245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FGM00_01255	COG2204	response regulator
FGM00_01270	COG1136	(ABC) transporter
FGM00_01275	COG0577	efflux transmembrane transporter activity
FGM00_01280	COG0577	efflux transmembrane transporter activity
FGM00_01285	COG0577	efflux transmembrane transporter activity
FGM00_01290	COG0577	efflux transmembrane transporter activity
FGM00_01295	COG0577	efflux transmembrane transporter activity
FGM00_01305	COG0577	efflux transmembrane transporter activity
FGM00_01305	COG1136	(ABC) transporter
FGM00_01315	COG0577	efflux transmembrane transporter activity
FGM00_01320	COG1136	(ABC) transporter
FGM00_01350	COG1115	amino acid carrier protein
FGM00_01355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FGM00_01360	COG1160	GTP binding
FGM00_01370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FGM00_01410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FGM00_01440	COG3186	Phenylalanine-4-hydroxylase
FGM00_01455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FGM00_01460	COG1388	LysM domain
FGM00_01460	COG1705	Flagellar rod assembly protein muramidase FlgJ
FGM00_01465	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FGM00_01525	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_01530	COG4221	oxidoreductase activity
FGM00_01535	COG1073	alpha beta
FGM00_01580	COG0471	metal ion transport
FGM00_01610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FGM00_01625	COG2197	response regulator
FGM00_01635	COG0321	lipoyl(octanoyl) transferase activity
FGM00_01670	COG1404	Belongs to the peptidase S8 family
FGM00_01685	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FGM00_01690	COG1629	transport
FGM00_01695	COG0561	phosphatase activity
FGM00_01740	COG0070	glutamate synthase
FGM00_01740	COG0069	glutamate synthase activity
FGM00_01740	COG0067	glutamate synthase
FGM00_01745	COG1960	acyl-CoA dehydrogenase activity
FGM00_01755	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FGM00_01760	COG0811	peptide transport
FGM00_01765	COG0848	biopolymer transport protein
FGM00_01775	COG0285	dihydrofolate synthase activity
FGM00_01800	COG0415	Belongs to the DNA photolyase family
FGM00_01815	COG3046	protein related to deoxyribodipyrimidine photolyase
FGM00_01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FGM00_01845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FGM00_01860	COG0295	cytidine deaminase activity
FGM00_01865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FGM00_01875	COG2234	aminopeptidase activity
FGM00_01885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FGM00_01905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FGM00_01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FGM00_01920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FGM00_01925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FGM00_01935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FGM00_01945	COG3292	Two component regulator propeller
FGM00_01945	COG2205	protein histidine kinase activity
FGM00_01945	COG0745	RESPONSE REGULATOR receiver
FGM00_01970	COG1999	signal sequence binding
FGM00_01985	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FGM00_01990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FGM00_01995	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FGM00_02000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FGM00_02010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FGM00_02015	COG2086	electron transfer activity
FGM00_02020	COG0508	dehydrogenase complex catalyzes the overall conversion of
FGM00_02020	COG0022	dehydrogenase e1 component
FGM00_02025	COG4206	TonB-dependent receptor
FGM00_02025	COG1629	transport
FGM00_02030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FGM00_02035	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FGM00_02050	COG1428	Deoxynucleoside kinase
FGM00_02055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FGM00_02065	COG0527	aspartate kinase activity
FGM00_02065	COG0460	homoserine dehydrogenase
FGM00_02090	COG3237	CsbD-like
FGM00_02095	COG0693	protein deglycase activity
FGM00_02110	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FGM00_02125	COG2197	response regulator
FGM00_02135	COG1959	2 iron, 2 sulfur cluster binding
FGM00_02145	COG0175	sulfate reduction
FGM00_02150	COG0175	sulfate reduction
FGM00_02155	COG2895	sulfate adenylyltransferase (ATP) activity
FGM00_02160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FGM00_02170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FGM00_02170	COG1648	precorrin-2 dehydrogenase activity
FGM00_02175	COG0492	ferredoxin-NADP+ reductase activity
FGM00_02185	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FGM00_02305	COG0646	methionine synthase
FGM00_02305	COG1410	methionine synthase
FGM00_02315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FGM00_02335	COG2197	response regulator
FGM00_02355	COG1131	(ABC) transporter
FGM00_02360	COG1605	Chorismate mutase
FGM00_02360	COG0077	Prephenate dehydratase
FGM00_02365	COG0436	Aminotransferase
FGM00_02375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FGM00_02380	COG1162	GTPase activity
FGM00_02385	COG1490	D-aminoacyl-tRNA deacylase activity
FGM00_02410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FGM00_02415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FGM00_02455	COG0358	DNA primase activity
FGM00_02460	COG2197	response regulator
FGM00_02465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FGM00_02480	COG0513	Belongs to the DEAD box helicase family
FGM00_02505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FGM00_02510	COG2267	carboxylic ester hydrolase activity
FGM00_02515	COG2001	Belongs to the MraZ family
FGM00_02520	COG0275	rRNA processing
FGM00_02530	COG0768	penicillin binding
FGM00_02535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FGM00_02540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FGM00_02545	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FGM00_02550	COG0772	Belongs to the SEDS family
FGM00_02555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FGM00_02560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FGM00_02575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FGM00_02580	COG1610	YqeY-like protein
FGM00_02625	COG1595	DNA-templated transcription, initiation
FGM00_02650	COG2197	response regulator
FGM00_02655	COG4585	Histidine kinase
FGM00_02665	COG0189	ligase activity
FGM00_02665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FGM00_02670	COG4242	Belongs to the peptidase S51 family
FGM00_02680	COG0492	ferredoxin-NADP+ reductase activity
FGM00_02685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FGM00_02690	COG2226	methyltransferase
FGM00_02700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FGM00_02705	COG4628	conserved protein (DUF2132)
FGM00_02710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FGM00_02720	COG1185	polyribonucleotide nucleotidyltransferase activity
FGM00_02725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FGM00_02735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FGM00_02740	COG0191	fructose-bisphosphate aldolase activity
FGM00_02750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FGM00_02765	COG2226	methyltransferase
FGM00_02770	COG0569	domain protein
FGM00_02775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FGM00_02815	COG3609	addiction module antidote protein, CC2985 family
FGM00_02860	COG3549	Plasmid maintenance system killer
FGM00_02890	COG4974	Belongs to the 'phage' integrase family
FGM00_02895	COG0436	Aminotransferase
FGM00_02900	COG3239	Fatty acid desaturase
FGM00_02905	COG0357	Ribosomal RNA small subunit methyltransferase G
FGM00_02925	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_02930	COG2967	ApaG domain
FGM00_02945	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FGM00_02950	COG1805	sodium ion transport
FGM00_02960	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FGM00_02965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FGM00_02980	COG1477	protein flavinylation
FGM00_03000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FGM00_03010	COG0501	Belongs to the peptidase M48B family
FGM00_03055	COG0671	phosphoesterase, PA-phosphatase related
FGM00_03070	COG3844	kynureninase activity
FGM00_03090	COG0740	serine-type endopeptidase activity
FGM00_03095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FGM00_03115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FGM00_03120	COG1663	tetraacyldisaccharide 4'-kinase activity
FGM00_03130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FGM00_03135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FGM00_03155	COG1595	DNA-templated transcription, initiation
FGM00_03160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FGM00_03165	COG0436	Aminotransferase
FGM00_03170	COG0750	zinc metalloprotease
FGM00_03180	COG0525	valine-tRNA ligase activity
FGM00_03205	COG1794	racemase activity, acting on amino acids and derivatives
FGM00_03230	COG2249	NAD(P)H dehydrogenase (quinone) activity
FGM00_03270	COG0688	phosphatidylethanolamine metabolic process
FGM00_03275	COG4589	Belongs to the CDS family
FGM00_03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FGM00_03290	COG0799	negative regulation of ribosome biogenesis
FGM00_03305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FGM00_03320	COG2201	protein-glutamate methylesterase activity
FGM00_03325	COG5002	protein histidine kinase activity
FGM00_03330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FGM00_03335	COG1181	Belongs to the D-alanine--D-alanine ligase family
FGM00_03340	COG0515	serine threonine protein kinase
FGM00_03340	COG2815	serine threonine protein kinase
FGM00_03345	COG0564	pseudouridine synthase activity
FGM00_03350	COG3022	response to hydroperoxide
FGM00_03365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FGM00_03375	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FGM00_03405	COG0159	tryptophan synthase activity
FGM00_03415	COG0133	tryptophan synthase activity
FGM00_03420	COG0135	phosphoribosylanthranilate isomerase activity
FGM00_03425	COG0134	indole-3-glycerol-phosphate synthase activity
FGM00_03430	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FGM00_03435	COG0512	Glutamine amidotransferase of anthranilate synthase
FGM00_03440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FGM00_03445	COG2353	YceI-like domain
FGM00_03450	COG1846	Transcriptional regulator
FGM00_03465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FGM00_03485	COG1115	amino acid carrier protein
FGM00_03495	COG1960	acyl-CoA dehydrogenase activity
FGM00_03500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FGM00_03505	COG4974	Belongs to the 'phage' integrase family
FGM00_03555	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FGM00_03560	COG0081	regulation of translation
FGM00_03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FGM00_03570	COG0222	ribosome binding
FGM00_03575	COG0085	RNA polymerase activity
FGM00_03580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FGM00_03595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FGM00_03635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FGM00_03645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FGM00_03650	COG1482	cell wall glycoprotein biosynthetic process
FGM00_03670	COG0561	phosphatase activity
FGM00_03690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FGM00_03720	COG2258	MOSC domain
FGM00_03750	COG1506	peptidase
FGM00_03755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FGM00_03765	COG4145	pantothenate transmembrane transporter activity
FGM00_03770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FGM00_03775	COG0508	dehydrogenase complex catalyzes the overall conversion of
FGM00_03805	COG0179	Fumarylacetoacetate (FAA) hydrolase
FGM00_03815	COG1058	Belongs to the CinA family
FGM00_03815	COG1546	Belongs to the CinA family
FGM00_03820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FGM00_03825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FGM00_03835	COG0552	protein localization to endoplasmic reticulum
FGM00_03845	COG0154	amidase activity
FGM00_03865	COG3530	Putative quorum-sensing-regulated virulence factor
FGM00_03870	COG0504	CTP synthase activity
FGM00_03875	COG0706	membrane insertase activity
FGM00_03880	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_03885	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_03890	COG0482	sulfurtransferase activity
FGM00_03910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FGM00_03920	COG2610	gluconate transmembrane transporter activity
FGM00_03925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FGM00_03930	COG0259	pyridoxamine-phosphate oxidase activity
FGM00_03950	COG0519	Catalyzes the synthesis of GMP from XMP
FGM00_03950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FGM00_03970	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FGM00_03990	COG2378	regulation of single-species biofilm formation
FGM00_04000	COG0793	Belongs to the peptidase S41A family
FGM00_04025	COG0714	Associated with various cellular activities
FGM00_04060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FGM00_04085	COG1473	amidohydrolase
FGM00_04090	COG0366	Alpha amylase catalytic
FGM00_04100	COG4974	Belongs to the 'phage' integrase family
FGM00_04115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FGM00_04145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FGM00_04160	COG1612	heme a metabolic process
FGM00_04180	COG0517	IMP dehydrogenase activity
FGM00_04180	COG0617	tRNA 3'-terminal CCA addition
FGM00_04180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FGM00_04185	COG0009	L-threonylcarbamoyladenylate synthase
FGM00_04190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FGM00_04220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FGM00_04225	COG0242	peptide deformylase activity
FGM00_04235	COG0823	Involved in the tonB-independent uptake of proteins
FGM00_04235	COG1506	peptidase
FGM00_04260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FGM00_04280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FGM00_04285	COG3956	TIGRFAM MazG family protein
FGM00_04295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGM00_04310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FGM00_04345	COG1595	DNA-templated transcription, initiation
FGM00_04350	COG2133	pyrroloquinoline quinone binding
FGM00_04355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FGM00_04360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FGM00_04365	COG2823	Periplasmic or secreted lipoprotein
FGM00_04365	COG1652	LysM domain
FGM00_04370	COG0539	negative regulation of cytoplasmic translation
FGM00_04380	COG0540	Belongs to the ATCase OTCase family
FGM00_04400	COG0259	pyridoxamine-phosphate oxidase activity
FGM00_04410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FGM00_04425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FGM00_04450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FGM00_04460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FGM00_04470	COG1454	alcohol dehydrogenase
FGM00_04490	COG0217	transcriptional regulatory protein
FGM00_04495	COG2154	pterin-4-alpha-carbinolamine dehydratase
FGM00_04505	COG2066	Belongs to the glutaminase family
FGM00_04510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FGM00_04520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FGM00_04525	COG0083	homoserine kinase activity
FGM00_04530	COG0460	homoserine dehydrogenase
FGM00_04530	COG0527	aspartate kinase activity
FGM00_04535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FGM00_04545	COG0542	response to heat
FGM00_04565	COG0183	Belongs to the thiolase family
FGM00_04590	COG1475	DNA binding
FGM00_04600	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_04605	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_04620	COG2169	Transcriptional regulator
FGM00_04625	COG0300	oxidoreductase activity
FGM00_04665	COG0604	alcohol dehydrogenase
FGM00_04730	COG2116	formate transmembrane transporter activity
FGM00_04735	COG3604	Transcriptional regulator
FGM00_04740	COG2207	Transcriptional regulator
FGM00_04740	COG1917	Cupin 2, conserved barrel domain protein
FGM00_04765	COG0702	epimerase
FGM00_04775	COG1335	isochorismatase
FGM00_04800	COG1335	isochorismatase
FGM00_04805	COG1335	isochorismatase
FGM00_04815	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_04820	COG0028	Belongs to the TPP enzyme family
FGM00_04830	COG2814	Major facilitator Superfamily
FGM00_04845	COG2267	carboxylic ester hydrolase activity
FGM00_04855	COG1335	isochorismatase
FGM00_04870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FGM00_04880	COG1538	Outer membrane efflux protein
FGM00_04890	COG1999	signal sequence binding
FGM00_04910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FGM00_04920	COG1629	transport
FGM00_04925	COG0702	epimerase
FGM00_04940	COG0673	inositol 2-dehydrogenase activity
FGM00_04945	COG3250	beta-galactosidase activity
FGM00_04965	COG3118	belongs to the thioredoxin family
FGM00_04970	COG0484	heat shock protein binding
FGM00_04975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FGM00_04995	COG0628	permease
FGM00_05005	COG4771	TonB-dependent receptor
FGM00_05045	COG3278	Belongs to the heme-copper respiratory oxidase family
FGM00_05055	COG2010	Cytochrome c
FGM00_05060	COG0348	domain, Protein
FGM00_05080	COG0589	response to stress
FGM00_05110	COG3119	arylsulfatase activity
FGM00_05120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FGM00_05125	COG0657	acetylesterase activity
FGM00_05125	COG2755	lipolytic protein G-D-S-L family
FGM00_05140	COG3119	arylsulfatase activity
FGM00_05145	COG3119	arylsulfatase activity
FGM00_05150	COG0457	Tetratricopeptide repeat
FGM00_05165	COG0477	Major facilitator Superfamily
FGM00_05165	COG2814	Major facilitator Superfamily
FGM00_05170	COG3119	arylsulfatase activity
FGM00_05185	COG0702	epimerase
FGM00_05190	COG4771	TonB-dependent receptor
FGM00_05215	COG0702	epimerase
FGM00_05220	COG4771	TonB-dependent receptor
FGM00_05225	COG1609	Transcriptional regulator
FGM00_05230	COG0702	epimerase
FGM00_05235	COG4771	TonB-dependent receptor
FGM00_05255	COG3119	arylsulfatase activity
FGM00_05260	COG3119	arylsulfatase activity
FGM00_05280	COG2271	Major facilitator Superfamily
FGM00_05300	COG3254	rhamnose metabolic process
FGM00_05305	COG0673	inositol 2-dehydrogenase activity
FGM00_05315	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FGM00_05325	COG1472	Belongs to the glycosyl hydrolase 3 family
FGM00_05330	COG3940	Belongs to the glycosyl hydrolase 43 family
FGM00_05340	COG1629	transport
FGM00_05345	COG0702	epimerase
FGM00_05350	COG3408	Glycogen debranching enzyme
FGM00_05360	COG3119	arylsulfatase activity
FGM00_05375	COG3119	arylsulfatase activity
FGM00_05390	COG3119	arylsulfatase activity
FGM00_05390	COG3408	Glycogen debranching enzyme
FGM00_05395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FGM00_05400	COG3119	arylsulfatase activity
FGM00_05405	COG0673	inositol 2-dehydrogenase activity
FGM00_05440	COG0702	epimerase
FGM00_05445	COG4771	TonB-dependent receptor
FGM00_05455	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_05455	COG3347	Dehydrogenase
FGM00_05460	COG4952	isomerase
FGM00_05470	COG1304	FMN binding
FGM00_05500	COG3119	arylsulfatase activity
FGM00_05505	COG1946	Acyl-CoA thioesterase
FGM00_05510	COG1063	alcohol dehydrogenase
FGM00_05535	COG0673	inositol 2-dehydrogenase activity
FGM00_05540	COG3119	arylsulfatase activity
FGM00_05545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FGM00_05550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FGM00_05555	COG3279	Response regulator of the LytR AlgR family
FGM00_05560	COG0492	ferredoxin-NADP+ reductase activity
FGM00_05570	COG0156	8-amino-7-oxononanoate synthase activity
FGM00_05575	COG4948	Mandelate Racemase Muconate Lactonizing
FGM00_05615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FGM00_05660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FGM00_05670	COG1475	DNA binding
FGM00_05675	COG1192	Involved in chromosome partitioning
FGM00_05685	COG0572	uridine kinase
FGM00_05690	COG2814	Major facilitator Superfamily
FGM00_05695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FGM00_05700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FGM00_05715	COG1472	Belongs to the glycosyl hydrolase 3 family
FGM00_05720	COG2211	Major facilitator Superfamily
FGM00_05725	COG0363	glucosamine-6-phosphate deaminase activity
FGM00_05730	COG1349	DNA-binding transcription factor activity
FGM00_05735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FGM00_05750	COG2133	pyrroloquinoline quinone binding
FGM00_05765	COG3119	arylsulfatase activity
FGM00_05780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_05785	COG0702	epimerase
FGM00_05790	COG4771	TonB-dependent receptor
FGM00_05800	COG0628	permease
FGM00_05820	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FGM00_05830	COG0205	6-phosphofructokinase activity
FGM00_05845	COG0251	oxidation-reduction process
FGM00_05855	COG0860	N-Acetylmuramoyl-L-alanine amidase
FGM00_05865	COG0247	lactate metabolic process
FGM00_05865	COG2181	nitrate reductase activity
FGM00_05870	COG2181	nitrate reductase activity
FGM00_05870	COG0247	lactate metabolic process
FGM00_05885	COG0438	transferase activity, transferring glycosyl groups
FGM00_05905	COG0367	asparagine synthase
FGM00_05910	COG0438	transferase activity, transferring glycosyl groups
FGM00_05920	COG0367	asparagine synthase
FGM00_05935	COG1216	Glycosyl transferase, family 2
FGM00_05935	COG1442	glycosyl transferase family 8
FGM00_05945	COG1216	Glycosyl transferase, family 2
FGM00_05955	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FGM00_05965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FGM00_05970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGM00_05995	COG1696	Membrane protein involved in D-alanine export
FGM00_06020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FGM00_06025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FGM00_06085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FGM00_06110	COG0592	DNA-directed DNA polymerase activity
FGM00_06135	COG1702	phosphate starvation-inducible protein PhoH
FGM00_06140	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FGM00_06155	COG2354	Protein conserved in bacteria
FGM00_06195	COG1678	Uncharacterized ACR, COG1678
FGM00_06205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FGM00_06210	COG0514	ATP-dependent DNA helicase (RecQ)
FGM00_06230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FGM00_06240	COG1233	COG1233 Phytoene dehydrogenase and related
FGM00_06255	COG0463	Glycosyl transferase, family 2
FGM00_06270	COG3119	arylsulfatase activity
FGM00_06300	COG0110	maltose O-acetyltransferase activity
FGM00_06305	COG1473	amidohydrolase
FGM00_06320	COG0415	Belongs to the DNA photolyase family
FGM00_06325	COG0415	Belongs to the DNA photolyase family
FGM00_06330	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_06360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FGM00_06375	COG0424	maF-like protein
FGM00_06390	COG1333	cytochrome c biogenesis protein
FGM00_06390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FGM00_06400	COG0534	Mate efflux family protein
FGM00_06405	COG0626	cystathionine gamma-synthase activity
FGM00_06410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FGM00_06415	COG2205	protein histidine kinase activity
FGM00_06415	COG2202	Pas domain
FGM00_06425	COG2234	aminopeptidase activity
FGM00_06435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FGM00_06440	COG3813	Protein conserved in bacteria
FGM00_06455	COG3938	Belongs to the proline racemase family
FGM00_06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FGM00_06475	COG1233	COG1233 Phytoene dehydrogenase and related
FGM00_06510	COG0673	inositol 2-dehydrogenase activity
FGM00_06530	COG0302	gtp cyclohydrolase
FGM00_06575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FGM00_06580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FGM00_06590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FGM00_06600	COG4771	TonB-dependent receptor
FGM00_06615	COG0012	GTP binding
FGM00_06630	COG1970	mechanosensitive ion channel activity
FGM00_06645	COG0861	Integral membrane protein TerC family
FGM00_06665	COG1522	sequence-specific DNA binding
FGM00_06680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FGM00_06695	COG0686	Belongs to the AlaDH PNT family
FGM00_06700	COG0802	atpase or kinase
FGM00_06705	COG2204	response regulator
FGM00_06710	COG1078	dGTPase activity
FGM00_06715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FGM00_06720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FGM00_06720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FGM00_06725	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FGM00_06735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FGM00_06740	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FGM00_06745	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FGM00_06750	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_06765	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FGM00_06775	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FGM00_06780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FGM00_06785	COG0131	Imidazoleglycerol-phosphate dehydratase
FGM00_06790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FGM00_06795	COG0454	-acetyltransferase
FGM00_06800	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FGM00_06815	COG0107	imidazoleglycerol-phosphate synthase activity
FGM00_06825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FGM00_06825	COG0140	phosphoribosyl-ATP diphosphatase activity
FGM00_06850	COG0640	Transcriptional regulator
FGM00_06860	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FGM00_06870	COG2311	Membrane
FGM00_06895	COG0101	tRNA pseudouridine synthase activity
FGM00_06900	COG0598	Magnesium transport protein CorA
FGM00_06915	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FGM00_06920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FGM00_06925	COG1984	allophanate hydrolase subunit 2
FGM00_06930	COG0129	dihydroxy-acid dehydratase activity
FGM00_06935	COG0028	Belongs to the TPP enzyme family
FGM00_06945	COG4106	trans-aconitate 2-methyltransferase activity
FGM00_06950	COG0440	acetolactate synthase activity
FGM00_06955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FGM00_06960	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_06975	COG1272	protein, Hemolysin III
FGM00_06980	COG1597	lipid kinase activity
FGM00_06990	COG1196	nuclear chromosome segregation
FGM00_07030	COG0473	3-isopropylmalate dehydrogenase activity
FGM00_07040	COG0066	3-isopropylmalate dehydratase activity
FGM00_07050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FGM00_07140	COG0542	response to heat
FGM00_07165	COG0791	NLP P60 protein
FGM00_07225	COG0246	Mannitol dehydrogenase
FGM00_07240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FGM00_07250	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FGM00_07290	COG4771	TonB-dependent receptor
FGM00_07295	COG0702	epimerase
FGM00_07315	COG2186	Transcriptional regulator
FGM00_07320	COG2271	Major facilitator Superfamily
FGM00_07335	COG0800	Aldolase
FGM00_07340	COG1914	H( )-stimulated, divalent metal cation uptake system
FGM00_07375	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_07385	COG0513	Belongs to the DEAD box helicase family
FGM00_07390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FGM00_07415	COG0596	Alpha beta hydrolase
FGM00_07480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FGM00_07485	COG0545	Peptidyl-prolyl cis-trans isomerase
FGM00_07490	COG1278	Cold shock
FGM00_07500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FGM00_07515	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_07575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGM00_07580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FGM00_07600	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_07630	COG0022	dehydrogenase e1 component
FGM00_07665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FGM00_07675	COG1193	negative regulation of DNA recombination
FGM00_07680	COG3011	Protein conserved in bacteria
FGM00_07685	COG4206	TonB-dependent receptor
FGM00_07685	COG1629	transport
FGM00_07690	COG0189	ligase activity
FGM00_07705	COG0189	ligase activity
FGM00_07710	COG1301	dicarboxylic acid transport
FGM00_07715	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FGM00_07720	COG0247	lactate metabolic process
FGM00_07720	COG0277	FAD linked oxidase domain protein
FGM00_07730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FGM00_07750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FGM00_07760	COG0405	Gamma-glutamyltransferase
FGM00_07815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FGM00_07820	COG1611	Belongs to the LOG family
FGM00_07830	COG0022	dehydrogenase e1 component
FGM00_07850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FGM00_07855	COG2259	Doxx family
FGM00_07880	COG0009	L-threonylcarbamoyladenylate synthase
FGM00_07900	COG1473	amidohydrolase
FGM00_07905	COG0069	glutamate synthase activity
FGM00_07930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FGM00_08040	COG1360	Flagellar Motor Protein
FGM00_08110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FGM00_08115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FGM00_08125	COG1233	COG1233 Phytoene dehydrogenase and related
FGM00_08130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FGM00_08140	COG1368	sulfuric ester hydrolase activity
FGM00_08195	COG1045	serine acetyltransferase
FGM00_08205	COG1914	H( )-stimulated, divalent metal cation uptake system
FGM00_08220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FGM00_08235	COG0606	chelatase, subunit chli
FGM00_08250	COG0037	tRNA processing
FGM00_08260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FGM00_08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FGM00_08285	COG1757	Na H antiporter
FGM00_08290	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FGM00_08300	COG1674	ftsk spoiiie
FGM00_08315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FGM00_08315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FGM00_08320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FGM00_08330	COG0730	response to heat
FGM00_08335	COG2356	endonuclease I
FGM00_08400	COG0318	PFAM AMP-dependent synthetase and ligase
FGM00_08415	COG2197	response regulator
FGM00_08420	COG1215	transferase activity, transferring glycosyl groups
FGM00_08430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FGM00_08465	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FGM00_08470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FGM00_08475	COG1595	DNA-templated transcription, initiation
FGM00_08480	COG1595	DNA-templated transcription, initiation
FGM00_08485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FGM00_08495	COG0564	pseudouridine synthase activity
FGM00_08540	COG0156	8-amino-7-oxononanoate synthase activity
FGM00_08555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FGM00_08575	COG2308	Evidence 4 Homologs of previously reported genes of
FGM00_08590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FGM00_08625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FGM00_08630	COG0346	lactoylglutathione lyase activity
FGM00_08635	COG0488	(ABC) transporter
FGM00_08650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FGM00_08680	COG2304	oxidoreductase activity
FGM00_08700	COG4948	Mandelate Racemase Muconate Lactonizing
FGM00_08705	COG0300	oxidoreductase activity
FGM00_08715	COG0784	Response regulator, receiver
FGM00_08720	COG1575	Belongs to the MenA family. Type 1 subfamily
FGM00_08730	COG2996	Protein conserved in bacteria
FGM00_08740	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FGM00_08745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FGM00_08775	COG0443	Heat shock 70 kDa protein
FGM00_08785	COG0010	Belongs to the arginase family
FGM00_08790	COG1760	l-serine dehydratase
FGM00_08820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FGM00_08825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FGM00_08830	COG0564	pseudouridine synthase activity
FGM00_08845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FGM00_08850	COG0473	3-isopropylmalate dehydrogenase activity
FGM00_08865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_08880	COG0488	(ABC) transporter
FGM00_08890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FGM00_08895	COG0300	oxidoreductase activity
FGM00_08970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FGM00_08985	COG0542	response to heat
FGM00_09005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FGM00_09010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FGM00_09020	COG0673	inositol 2-dehydrogenase activity
FGM00_09025	COG1250	3-hydroxyacyl-CoA dehydrogenase
FGM00_09035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FGM00_09040	COG2176	DNA-directed DNA polymerase activity
FGM00_09045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FGM00_09050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FGM00_09055	COG3265	gluconokinase activity
FGM00_09070	COG0237	dephospho-CoA kinase activity
FGM00_09080	COG1215	transferase activity, transferring glycosyl groups
FGM00_09085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FGM00_09090	COG0497	DNA recombination
FGM00_09115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FGM00_09125	COG0737	Belongs to the 5'-nucleotidase family
FGM00_09130	COG0737	Belongs to the 5'-nucleotidase family
FGM00_09175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FGM00_09200	COG2890	protein-(glutamine-N5) methyltransferase activity
FGM00_09205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FGM00_09205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FGM00_09210	COG1011	Hydrolase
FGM00_09215	COG0697	spore germination
FGM00_09220	COG1739	Uncharacterized protein family UPF0029
FGM00_09225	COG0824	Thioesterase
FGM00_09230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FGM00_09235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FGM00_09240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FGM00_09250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FGM00_09260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FGM00_09280	COG0456	acetyltransferase
FGM00_09285	COG0336	Belongs to the RNA methyltransferase TrmD family
FGM00_09295	COG0335	large ribosomal subunit rRNA binding
FGM00_09315	COG1929	Belongs to the glycerate kinase type-1 family
FGM00_09330	COG1363	Peptidase, m42
FGM00_09335	COG1051	belongs to the nudix hydrolase family
FGM00_09340	COG0124	histidyl-tRNA synthetase
FGM00_09355	COG0359	binds to the 23S rRNA
FGM00_09360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FGM00_09365	COG0360	Binds together with S18 to 16S ribosomal RNA
FGM00_09370	COG3279	Response regulator of the LytR AlgR family
FGM00_09375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FGM00_09385	COG1295	ribonuclease BN
FGM00_09395	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FGM00_09400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FGM00_09420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FGM00_09425	COG0513	Belongs to the DEAD box helicase family
FGM00_09435	COG0366	Alpha amylase catalytic
FGM00_09455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FGM00_09545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGM00_09550	COG1120	ATPase activity
FGM00_09570	COG0363	glucosamine-6-phosphate deaminase activity
FGM00_09575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FGM00_09580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FGM00_09610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FGM00_09640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FGM00_09650	COG0254	rRNA binding
FGM00_09660	COG0463	Glycosyl transferase, family 2
FGM00_09665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FGM00_09670	COG1132	(ABC) transporter
FGM00_09725	COG1595	DNA-templated transcription, initiation
FGM00_09730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FGM00_09730	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FGM00_09735	COG3152	Membrane
FGM00_09745	COG2852	Protein conserved in bacteria
FGM00_09780	COG1022	Amp-dependent synthetase and ligase
FGM00_09820	COG1250	3-hydroxyacyl-CoA dehydrogenase
FGM00_09820	COG1024	Enoyl-CoA hydratase
FGM00_09825	COG0183	Belongs to the thiolase family
FGM00_09835	COG1960	acyl-CoA dehydrogenase activity
FGM00_09845	COG0076	glutamate decarboxylase activity
FGM00_09850	COG3387	PFAM Glycoside hydrolase 15-related
FGM00_09855	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FGM00_09915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FGM00_09920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FGM00_09950	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FGM00_09955	COG0702	epimerase
FGM00_10050	COG3279	Response regulator of the LytR AlgR family
FGM00_10075	COG3275	phosphorelay sensor kinase activity
FGM00_10095	COG2031	fatty acid transporter
FGM00_10100	COG0823	Involved in the tonB-independent uptake of proteins
FGM00_10100	COG1506	peptidase
FGM00_10100	COG4946	Tricorn protease homolog
FGM00_10105	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FGM00_10110	COG0513	Belongs to the DEAD box helicase family
FGM00_10115	COG0857	belongs to the CobB CobQ family
FGM00_10115	COG0280	phosphate acetyltransferase
FGM00_10120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FGM00_10130	COG0668	transmembrane transport
FGM00_10150	COG2267	carboxylic ester hydrolase activity
FGM00_10165	COG1064	alcohol dehydrogenase
FGM00_10260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGM00_10265	COG0494	nUDIX hydrolase
FGM00_10285	COG0300	oxidoreductase activity
FGM00_10310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FGM00_10320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FGM00_10335	COG0105	UTP biosynthetic process
FGM00_10345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FGM00_10355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FGM00_10365	COG0501	Belongs to the peptidase M48B family
FGM00_10370	COG2195	Cleaves the N-terminal amino acid of tripeptides
FGM00_10380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FGM00_10395	COG2852	Protein conserved in bacteria
FGM00_10400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FGM00_10400	COG3608	succinylglutamate desuccinylase aspartoacylase
FGM00_10435	COG1104	cysteine desulfurase activity
FGM00_10440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FGM00_10445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FGM00_10450	COG0303	'Molybdopterin
FGM00_10475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FGM00_10480	COG2852	Protein conserved in bacteria
FGM00_10485	COG0315	cyclic pyranopterin monophosphate synthase activity
FGM00_10485	COG0746	molybdenum cofactor guanylyltransferase activity
FGM00_10490	COG0315	cyclic pyranopterin monophosphate synthase activity
FGM00_10495	COG0314	molybdopterin synthase activity
FGM00_10510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FGM00_10515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FGM00_10520	COG0735	belongs to the Fur family
FGM00_10525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FGM00_10545	COG0673	inositol 2-dehydrogenase activity
FGM00_10555	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FGM00_10575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FGM00_10585	COG1418	mRNA catabolic process
FGM00_10605	COG0739	heme binding
FGM00_10620	COG1104	cysteine desulfurase activity
FGM00_10650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FGM00_10660	COG1595	DNA-templated transcription, initiation
FGM00_10665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FGM00_10680	COG0116	Belongs to the methyltransferase superfamily
FGM00_10700	COG1272	protein, Hemolysin III
FGM00_10705	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FGM00_10735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FGM00_10740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FGM00_10745	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FGM00_10750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FGM00_10760	COG0561	phosphatase activity
FGM00_10770	COG0305	Participates in initiation and elongation during chromosome replication
FGM00_10775	COG0825	malonyl-CoA metabolic process
FGM00_10790	COG0343	queuine tRNA-ribosyltransferase activity
FGM00_10795	COG3959	Transketolase, thiamine diphosphate binding domain
FGM00_10800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FGM00_10820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FGM00_10825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FGM00_10835	COG4974	Belongs to the 'phage' integrase family
FGM00_10875	COG3237	CsbD-like
FGM00_10885	COG2176	DNA-directed DNA polymerase activity
FGM00_10895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FGM00_10900	COG0587	DNA-directed DNA polymerase activity
FGM00_10925	COG0860	N-Acetylmuramoyl-L-alanine amidase
FGM00_10975	COG3328	transposase activity
FGM00_11010	COG0629	single-stranded DNA binding
FGM00_11025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FGM00_11065	COG1234	tRNA 3'-trailer cleavage
FGM00_11085	COG0786	glutamate:sodium symporter activity
FGM00_11095	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FGM00_11100	COG1027	Aspartate ammonia-lyase
FGM00_11105	COG0252	asparaginase activity
FGM00_11115	COG1053	succinate dehydrogenase
FGM00_11120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FGM00_11130	COG2860	membrane
FGM00_11325	COG3451	type IV secretory pathway VirB4
FGM00_11345	COG2755	lipolytic protein G-D-S-L family
FGM00_11345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FGM00_11350	COG3279	Response regulator of the LytR AlgR family
FGM00_11355	COG5002	protein histidine kinase activity
FGM00_11365	COG0366	Alpha amylase catalytic
FGM00_11420	COG1741	Belongs to the pirin family
FGM00_11430	COG0598	Magnesium transport protein CorA
FGM00_11460	COG1233	COG1233 Phytoene dehydrogenase and related
FGM00_11485	COG0714	Associated with various cellular activities
FGM00_11490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FGM00_11530	COG3250	beta-galactosidase activity
FGM00_11535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FGM00_11560	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FGM00_11565	COG0514	ATP-dependent DNA helicase (RecQ)
FGM00_11570	COG0517	IMP dehydrogenase activity
FGM00_11570	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FGM00_11575	COG0805	protein transport
FGM00_11585	COG1137	ATPase activity
FGM00_11600	COG1183	phosphatidylcholine synthase activity
FGM00_11610	COG0488	(ABC) transporter
FGM00_11620	COG2096	Adenosyltransferase
FGM00_11630	COG0653	protein targeting
FGM00_11650	COG2226	methyltransferase
FGM00_11655	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FGM00_11680	COG1902	pentaerythritol trinitrate reductase activity
FGM00_11685	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_11705	COG4181	ATPase activity
FGM00_11725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGM00_11740	COG1595	DNA-templated transcription, initiation
FGM00_11745	COG2017	converts alpha-aldose to the beta-anomer
FGM00_11755	COG1703	isobutyryl-CoA mutase activity
FGM00_11760	COG0463	Glycosyl transferase, family 2
FGM00_11770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FGM00_11775	COG0671	phosphoesterase, PA-phosphatase related
FGM00_11785	COG0534	Mate efflux family protein
FGM00_11795	COG1131	(ABC) transporter
FGM00_11810	COG0556	nucleotide-excision repair
FGM00_11940	COG0045	succinate-CoA ligase (ADP-forming) activity
FGM00_11950	COG0019	diaminopimelate decarboxylase activity
FGM00_11965	COG1131	(ABC) transporter
FGM00_11975	COG0517	IMP dehydrogenase activity
FGM00_11975	COG0516	GMP reductase activity
FGM00_12030	COG0167	dihydroorotate dehydrogenase activity
FGM00_12040	COG2195	Cleaves the N-terminal amino acid of tripeptides
FGM00_12050	COG1862	Preprotein translocase
FGM00_12060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FGM00_12065	COG1132	(ABC) transporter
FGM00_12085	COG0385	Bile acid
FGM00_12090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGM00_12110	COG2318	DinB family
FGM00_12115	COG0450	alkyl hydroperoxide reductase
FGM00_12120	COG1278	Cold shock
FGM00_12125	COG1404	Belongs to the peptidase S8 family
FGM00_12130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FGM00_12140	COG2326	polyphosphate kinase activity
FGM00_12150	COG2204	response regulator
FGM00_12160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FGM00_12160	COG3264	Mechanosensitive ion channel
FGM00_12165	COG1668	transmembrane transport
FGM00_12170	COG4152	abc transporter atp-binding protein
FGM00_12175	COG0484	heat shock protein binding
FGM00_12180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FGM00_12185	COG1090	epimerase
FGM00_12190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FGM00_12190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FGM00_12225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FGM00_12230	COG0347	Belongs to the P(II) protein family
FGM00_12235	COG0004	ammonium transporteR
FGM00_12265	COG1522	sequence-specific DNA binding
FGM00_12275	COG0788	formyltetrahydrofolate deformylase activity
FGM00_12290	COG1629	transport
FGM00_12300	COG4771	TonB-dependent receptor
FGM00_12320	COG0284	orotidine-5'-phosphate decarboxylase activity
FGM00_12325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FGM00_12340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FGM00_12360	COG0174	glutamine synthetase
FGM00_12375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FGM00_12390	COG1022	Amp-dependent synthetase and ligase
FGM00_12400	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_12405	COG3321	synthase
FGM00_12405	COG0604	alcohol dehydrogenase
FGM00_12405	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_12410	COG2130	NADP-dependent
FGM00_12420	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_12435	COG1960	acyl-CoA dehydrogenase activity
FGM00_12440	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_12445	COG1960	acyl-CoA dehydrogenase activity
FGM00_12465	COG2264	protein methyltransferase activity
FGM00_12470	COG0149	triose-phosphate isomerase activity
FGM00_12485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FGM00_12500	COG1132	(ABC) transporter
FGM00_12505	COG0101	tRNA pseudouridine synthase activity
FGM00_12540	COG0268	Binds directly to 16S ribosomal RNA
FGM00_12555	COG0442	prolyl-tRNA aminoacylation
FGM00_12580	COG0302	gtp cyclohydrolase
FGM00_12585	COG0215	cysteine-tRNA ligase activity
FGM00_12590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FGM00_12605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FGM00_12625	COG1119	ATPase activity
FGM00_12630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FGM00_12645	COG0187	DNA topoisomerase II activity
FGM00_12650	COG0367	asparagine synthase
FGM00_12660	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FGM00_12710	COG2884	Cell division ATP-binding protein ftsE
FGM00_12745	COG1217	gtp-binding protein TYPA
FGM00_12765	COG3275	phosphorelay sensor kinase activity
FGM00_12770	COG3279	Response regulator of the LytR AlgR family
FGM00_12780	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FGM00_12825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FGM00_12825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FGM00_12835	COG2176	DNA-directed DNA polymerase activity
FGM00_12840	COG2197	response regulator
FGM00_12905	COG4771	TonB-dependent receptor
FGM00_12925	COG1222	aaa ATPase
FGM00_12955	COG1404	Belongs to the peptidase S8 family
FGM00_12955	COG4935	Belongs to the peptidase S8 family
FGM00_12970	COG3292	Two component regulator propeller
FGM00_12970	COG2205	protein histidine kinase activity
FGM00_12970	COG0745	RESPONSE REGULATOR receiver
FGM00_12975	COG4771	TonB-dependent receptor
FGM00_12985	COG3119	arylsulfatase activity
FGM00_12990	COG3250	beta-galactosidase activity
FGM00_12995	COG3940	Belongs to the glycosyl hydrolase 43 family
FGM00_13000	COG3940	Belongs to the glycosyl hydrolase 43 family
FGM00_13015	COG2827	Endonuclease containing a URI domain
FGM00_13080	COG3876	Protein conserved in bacteria
FGM00_13115	COG0602	queuosine metabolic process
FGM00_13120	COG0433	COG0433 Predicted ATPase
FGM00_13130	COG1733	regulation of RNA biosynthetic process
FGM00_13135	COG0596	Alpha beta hydrolase
FGM00_13155	COG2382	esterase
FGM00_13170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGM00_13175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FGM00_13185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FGM00_13205	COG0667	Aldo Keto reductase
FGM00_13240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FGM00_13245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FGM00_13275	COG0018	arginyl-trna synthetase
FGM00_13285	COG0702	epimerase
FGM00_13315	COG0148	phosphopyruvate hydratase activity
FGM00_13320	COG0505	Belongs to the CarA family
FGM00_13325	COG0203	ribosomal protein L17
FGM00_13330	COG0202	RNA polymerase activity
FGM00_13335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FGM00_13340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FGM00_13345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FGM00_13350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FGM00_13355	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FGM00_13365	COG0200	Binds to the 23S rRNA
FGM00_13370	COG1841	ribosomal large subunit assembly
FGM00_13375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FGM00_13380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FGM00_13385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FGM00_13390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FGM00_13395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FGM00_13400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FGM00_13405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FGM00_13410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FGM00_13415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FGM00_13420	COG0255	Belongs to the universal ribosomal protein uL29 family
FGM00_13425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FGM00_13430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FGM00_13435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FGM00_13440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FGM00_13445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FGM00_13450	COG0089	rRNA binding
FGM00_13455	COG0088	Forms part of the polypeptide exit tunnel
FGM00_13460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FGM00_13465	COG0051	transcription antitermination factor activity, RNA binding
FGM00_13470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FGM00_13475	COG0049	tRNA binding
FGM00_13480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FGM00_13485	COG4771	TonB-dependent receptor
FGM00_13535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FGM00_13560	COG1011	Hydrolase
FGM00_13570	COG2003	Belongs to the UPF0758 family
FGM00_13590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FGM00_13605	COG1360	Flagellar Motor Protein
FGM00_13610	COG1505	serine-type exopeptidase activity
FGM00_13615	COG1505	serine-type exopeptidase activity
FGM00_13635	COG3279	Response regulator of the LytR AlgR family
FGM00_13640	COG2972	Histidine kinase
FGM00_13660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FGM00_13665	COG0563	adenylate kinase activity
FGM00_13670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FGM00_13680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FGM00_13685	COG0339	signal peptide processing
FGM00_13730	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FGM00_13730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FGM00_13735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FGM00_13745	COG1215	transferase activity, transferring glycosyl groups
FGM00_13760	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FGM00_13765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FGM00_13775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FGM00_13785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FGM00_13790	COG0596	Alpha beta hydrolase
FGM00_13800	COG1950	PFAM Membrane protein of
FGM00_13805	COG0544	peptidyl-prolyl cis-trans isomerase activity
FGM00_13815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FGM00_13855	COG0616	signal peptide processing
FGM00_13860	COG1428	Deoxynucleoside kinase
FGM00_13875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FGM00_13935	COG0673	inositol 2-dehydrogenase activity
FGM00_13960	COG1309	transcriptional regulator
FGM00_13965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FGM00_13970	COG0179	Fumarylacetoacetate (FAA) hydrolase
FGM00_13975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FGM00_13990	COG2949	membrane
FGM00_14015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FGM00_14020	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FGM00_14025	COG2197	response regulator
FGM00_14055	COG0316	Belongs to the HesB IscA family
FGM00_14055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FGM00_14065	COG1331	Highly conserved protein containing a thioredoxin domain
FGM00_14070	COG0668	transmembrane transport
FGM00_14075	COG1214	PFAM Peptidase M22, glycoprotease
FGM00_14085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FGM00_14090	COG0577	efflux transmembrane transporter activity
FGM00_14090	COG1136	(ABC) transporter
FGM00_14095	COG0577	efflux transmembrane transporter activity
FGM00_14095	COG1136	(ABC) transporter
FGM00_14100	COG1136	(ABC) transporter
FGM00_14110	COG0577	efflux transmembrane transporter activity
FGM00_14110	COG1136	(ABC) transporter
FGM00_14115	COG1136	(ABC) transporter
FGM00_14115	COG0577	efflux transmembrane transporter activity
FGM00_14125	COG2322	membrane
FGM00_14130	COG1999	signal sequence binding
FGM00_14155	COG0109	protoheme IX farnesyltransferase activity
FGM00_14175	COG0509	glycine decarboxylation via glycine cleavage system
FGM00_14185	COG0632	four-way junction helicase activity
FGM00_14205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FGM00_14255	COG0745	RESPONSE REGULATOR receiver
FGM00_14255	COG2205	protein histidine kinase activity
FGM00_14255	COG3292	Two component regulator propeller
FGM00_14260	COG4555	ABC transporter
FGM00_14265	COG1668	transmembrane transport
FGM00_14280	COG2255	four-way junction helicase activity
FGM00_14315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FGM00_14340	COG3743	rRNA binding
FGM00_14340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FGM00_14345	COG0437	4 iron, 4 sulfur cluster binding
FGM00_14360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FGM00_14365	COG0195	Participates in both transcription termination and antitermination
FGM00_14370	COG0779	Required for maturation of 30S ribosomal subunits
FGM00_14395	COG3118	belongs to the thioredoxin family
FGM00_14405	COG3142	Participates in the control of copper homeostasis
FGM00_14410	COG1446	asparaginase
FGM00_14415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FGM00_14415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FGM00_14435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FGM00_14440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FGM00_14445	COG0052	Belongs to the universal ribosomal protein uS2 family
FGM00_14450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FGM00_14470	COG1595	DNA-templated transcription, initiation
FGM00_14480	COG0528	UMP kinase activity
FGM00_14485	COG0233	cytoplasmic translational termination
FGM00_14495	COG0017	Asparaginyl-tRNA synthetase
FGM00_14540	COG0811	peptide transport
FGM00_14550	COG0252	asparaginase activity
FGM00_14555	COG0084	hydrolase, TatD family'
FGM00_14565	COG1858	cytochrome C peroxidase
FGM00_14570	COG0508	dehydrogenase complex catalyzes the overall conversion of
FGM00_14575	COG0567	Dehydrogenase, E1 component
FGM00_14595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FGM00_14605	COG1519	Transferase
FGM00_14605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FGM00_14610	COG2814	Major facilitator Superfamily
FGM00_14635	COG4251	negative regulation of phosphorylation
FGM00_14645	COG4251	negative regulation of phosphorylation
FGM00_14690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FGM00_14730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FGM00_14735	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FGM00_14780	COG0583	DNA-binding transcription factor activity
FGM00_14785	COG2986	histidine ammonia-lyase
FGM00_14795	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FGM00_14800	COG0010	Belongs to the arginase family
FGM00_14845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FGM00_14870	COG1566	PFAM secretion protein HlyD family protein
FGM00_14875	COG1538	Outer membrane efflux protein
FGM00_14885	COG3119	arylsulfatase activity
FGM00_14890	COG3119	arylsulfatase activity
FGM00_14895	COG1741	Belongs to the pirin family
FGM00_14950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FGM00_14955	COG3177	Filamentation induced by cAMP protein fic
FGM00_14970	COG3118	belongs to the thioredoxin family
FGM00_14980	COG3119	arylsulfatase activity
FGM00_14985	COG0228	four-way junction DNA binding
FGM00_14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FGM00_15000	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FGM00_15005	COG1960	acyl-CoA dehydrogenase activity
FGM00_15020	COG0587	DNA-directed DNA polymerase activity
FGM00_15035	COG4585	Histidine kinase
FGM00_15050	COG0673	inositol 2-dehydrogenase activity
FGM00_15060	COG3119	arylsulfatase activity
FGM00_15065	COG3119	arylsulfatase activity
FGM00_15075	COG3408	Glycogen debranching enzyme
FGM00_15080	COG4771	TonB-dependent receptor
FGM00_15085	COG0702	epimerase
FGM00_15090	COG3250	beta-galactosidase activity
FGM00_15095	COG2211	Major facilitator Superfamily
FGM00_15100	COG3119	arylsulfatase activity
FGM00_15110	COG3119	arylsulfatase activity
FGM00_15120	COG3347	Dehydrogenase
FGM00_15120	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_15145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FGM00_15150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FGM00_15155	COG0193	aminoacyl-tRNA hydrolase activity
FGM00_15170	COG0196	riboflavin kinase activity
FGM00_15180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FGM00_15195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FGM00_15200	COG2239	Acts as a magnesium transporter
FGM00_15215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FGM00_15220	COG2197	response regulator
FGM00_15260	COG1247	-acetyltransferase
FGM00_15265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FGM00_15275	COG0527	aspartate kinase activity
FGM00_15290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FGM00_15310	COG1793	dna ligase
FGM00_15320	COG1201	RNA secondary structure unwinding
FGM00_15390	COG0300	oxidoreductase activity
FGM00_15395	COG0405	Gamma-glutamyltransferase
FGM00_15420	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_15425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FGM00_15455	COG0792	nuclease activity
FGM00_15470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGM00_15470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGM00_15495	COG2197	response regulator
FGM00_15530	COG0123	including yeast histone deacetylase and acetoin utilization protein
FGM00_15535	COG0671	phosphoesterase, PA-phosphatase related
FGM00_15540	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FGM00_15545	COG0110	maltose O-acetyltransferase activity
FGM00_15555	COG4771	TonB-dependent receptor
FGM00_15560	COG0702	epimerase
FGM00_15595	COG0644	oxidoreductase
FGM00_15600	COG2986	histidine ammonia-lyase
FGM00_15615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FGM00_15620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGM00_15635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FGM00_15660	COG1131	(ABC) transporter
FGM00_15690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGM00_15695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FGM00_15720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FGM00_15730	COG0463	Glycosyl transferase, family 2
FGM00_15755	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FGM00_15765	COG0514	ATP-dependent DNA helicase (RecQ)
FGM00_15770	COG0629	single-stranded DNA binding
FGM00_15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGM00_15865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGM00_15870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FGM00_15875	COG0189	ligase activity
FGM00_15875	COG4067	protein conserved in archaea
FGM00_15900	COG0612	Peptidase, M16
FGM00_15910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FGM00_15920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FGM00_15995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FGM00_16015	COG2133	pyrroloquinoline quinone binding
FGM00_16025	COG2706	6-phosphogluconolactonase activity
FGM00_16060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FGM00_16090	COG1981	membrane
FGM00_16110	COG1418	mRNA catabolic process
FGM00_16165	COG1733	regulation of RNA biosynthetic process
FGM00_16180	COG1024	Enoyl-CoA hydratase
FGM00_16190	COG5000	phosphorelay sensor kinase activity
FGM00_16205	COG0793	Belongs to the peptidase S41A family
FGM00_16215	COG2095	MarC family integral membrane protein
FGM00_16225	COG2972	Histidine kinase
FGM00_16230	COG3279	Response regulator of the LytR AlgR family
FGM00_16315	COG3292	Two component regulator propeller
FGM00_16315	COG2205	protein histidine kinase activity
FGM00_16315	COG0745	RESPONSE REGULATOR receiver
FGM00_16355	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FGM00_16355	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FGM00_16360	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FGM00_16385	COG2318	DinB family
FGM00_16395	COG0673	inositol 2-dehydrogenase activity
FGM00_16425	COG1561	YicC-like family, N-terminal region
FGM00_16430	COG0194	GDP metabolic process
FGM00_16435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FGM00_16440	COG4682	membrane
FGM00_16490	COG4771	TonB-dependent receptor
FGM00_16495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FGM00_16505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FGM00_16540	COG1404	Belongs to the peptidase S8 family
FGM00_16545	COG3279	Response regulator of the LytR AlgR family
FGM00_16555	COG0590	tRNA wobble adenosine to inosine editing
FGM00_16560	COG1278	Cold shock
FGM00_16605	COG0463	Glycosyl transferase, family 2
FGM00_16640	COG0438	transferase activity, transferring glycosyl groups
FGM00_16665	COG3206	protein involved in exopolysaccharide biosynthesis
FGM00_16665	COG0489	protein tyrosine kinase activity
FGM00_16685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FGM00_16705	COG1309	transcriptional regulator
FGM00_16730	COG4771	TonB-dependent receptor
FGM00_16735	COG1321	iron dependent repressor
FGM00_16735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FGM00_16760	COG0823	Involved in the tonB-independent uptake of proteins
FGM00_16775	COG4946	Tricorn protease homolog
FGM00_16775	COG0793	Belongs to the peptidase S41A family
FGM00_16785	COG1309	transcriptional regulator
FGM00_16790	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_16800	COG2363	Small membrane protein
FGM00_16810	COG1228	amidohydrolase
FGM00_16855	COG1999	signal sequence binding
FGM00_16860	COG0750	zinc metalloprotease
FGM00_16880	COG4977	sequence-specific DNA binding
FGM00_16880	COG1917	Cupin 2, conserved barrel domain protein
FGM00_16915	COG0300	oxidoreductase activity
FGM00_16925	COG1648	precorrin-2 dehydrogenase activity
FGM00_16925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FGM00_16930	COG4585	Histidine kinase
FGM00_16945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FGM00_16950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FGM00_16950	COG1648	precorrin-2 dehydrogenase activity
FGM00_16955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FGM00_16955	COG1116	anion transmembrane transporter activity
FGM00_16960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FGM00_16965	COG1116	anion transmembrane transporter activity
FGM00_16970	COG1116	anion transmembrane transporter activity
FGM00_16985	COG0243	molybdopterin cofactor binding
FGM00_16990	COG1773	rubredoxin
FGM00_16995	COG3340	Belongs to the peptidase S51 family
FGM00_17015	COG2205	protein histidine kinase activity
FGM00_17015	COG0784	Response regulator, receiver
FGM00_17020	COG0408	coproporphyrinogen oxidase activity
FGM00_17040	COG0113	porphobilinogen synthase activity
FGM00_17045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FGM00_17050	COG1253	flavin adenine dinucleotide binding
FGM00_17075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FGM00_17085	COG3609	addiction module antidote protein, CC2985 family
FGM00_17120	COG2151	metal-sulfur cluster biosynthetic enzyme
FGM00_17125	COG2166	iron-sulfur cluster assembly
FGM00_17140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FGM00_17150	COG0719	Fe-S assembly protein
FGM00_17160	COG0396	ATPase activity
FGM00_17170	COG0719	Fe-S assembly protein
FGM00_17175	COG0316	Belongs to the HesB IscA family
FGM00_17195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FGM00_17220	COG1131	(ABC) transporter
FGM00_17225	COG3275	phosphorelay sensor kinase activity
FGM00_17230	COG3279	Response regulator of the LytR AlgR family
FGM00_17235	COG0006	proline dipeptidase activity
FGM00_17245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FGM00_17275	COG0666	response to abiotic stimulus
FGM00_17295	COG0189	ligase activity
FGM00_17300	COG0745	RESPONSE REGULATOR receiver
FGM00_17300	COG3292	Two component regulator propeller
FGM00_17300	COG2205	protein histidine kinase activity
FGM00_17300	COG0745	RESPONSE REGULATOR receiver
FGM00_17300	COG2205	protein histidine kinase activity
FGM00_17300	COG3292	Two component regulator propeller
FGM00_17330	COG1053	succinate dehydrogenase
FGM00_17335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FGM00_17345	COG0693	protein deglycase activity
FGM00_17350	COG0436	Aminotransferase
FGM00_17380	COG1774	PSP1 C-terminal conserved region
FGM00_17390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FGM00_17415	COG0180	Tryptophanyl-tRNA synthetase
FGM00_17425	COG0545	Peptidyl-prolyl cis-trans isomerase
FGM00_17430	COG0758	DNA mediated transformation
FGM00_17430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FGM00_17445	COG0656	L-ascorbic acid biosynthetic process
FGM00_17465	COG0756	dUTP diphosphatase activity
FGM00_17495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FGM00_17500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FGM00_17505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FGM00_17510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FGM00_17515	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FGM00_17520	COG0356	it plays a direct role in the translocation of protons across the membrane
FGM00_17545	COG4941	Belongs to the sigma-70 factor family
FGM00_17560	COG1131	(ABC) transporter
FGM00_17570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FGM00_17590	COG4206	TonB-dependent receptor
FGM00_17590	COG1629	transport
FGM00_17610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FGM00_17645	COG0151	Belongs to the GarS family
FGM00_17650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGM00_17655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FGM00_17705	COG0728	peptidoglycan biosynthetic process
FGM00_17710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FGM00_17715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FGM00_17720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FGM00_17765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FGM00_17790	COG1388	LysM domain
FGM00_17790	COG0791	NLP P60 protein
FGM00_17795	COG0126	phosphoglycerate kinase activity
FGM00_17825	COG0445	tRNA wobble uridine modification
FGM00_17830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FGM00_17845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FGM00_17855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FGM00_17910	COG0557	exoribonuclease II activity
FGM00_17915	COG0698	ribose 5-phosphate isomerase
FGM00_17920	COG2153	protein acetylation
FGM00_17940	COG0791	NLP P60 protein
FGM00_17950	COG3001	Fructosamine kinase
FGM00_17980	COG0793	Belongs to the peptidase S41A family
FGM00_17985	COG0594	ribonuclease P activity
FGM00_18000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FGM00_18015	COG0481	GTPase activity
FGM00_18045	COG2234	aminopeptidase activity
FGM00_18060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FGM00_18065	COG0346	lactoylglutathione lyase activity
FGM00_18075	COG0531	amino acid
FGM00_18090	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FGM00_18135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FGM00_18155	COG1904	glucuronate isomerase
FGM00_18160	COG0673	inositol 2-dehydrogenase activity
FGM00_18170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FGM00_18180	COG4677	pectinesterase activity
FGM00_18185	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_18190	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FGM00_18195	COG1312	Catalyzes the dehydration of D-mannonate
FGM00_18200	COG1028	Short-chain dehydrogenase reductase Sdr
FGM00_18210	COG0745	RESPONSE REGULATOR receiver
FGM00_18210	COG2205	protein histidine kinase activity
FGM00_18210	COG3292	Two component regulator propeller
FGM00_18215	COG4771	TonB-dependent receptor
FGM00_18220	COG0702	epimerase
FGM00_18225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FGM00_18230	COG3250	beta-galactosidase activity
FGM00_18240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FGM00_18310	COG0783	Belongs to the Dps family
FGM00_18340	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_18350	COG0590	tRNA wobble adenosine to inosine editing
FGM00_18435	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FGM00_18460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FGM00_18465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FGM00_18475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FGM00_18480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FGM00_18485	COG0511	ligase activity, forming carbon-carbon bonds
FGM00_18490	COG0439	Biotin carboxylase
FGM00_18520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FGM00_18535	COG1505	serine-type exopeptidase activity
FGM00_18540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FGM00_18550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FGM00_18555	COG1435	thymidine kinase activity
FGM00_18565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FGM00_18575	COG1573	uracil-dna glycosylase
FGM00_18595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FGM00_18595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FGM00_18600	COG0346	lactoylglutathione lyase activity
FGM00_18605	COG2211	Major facilitator Superfamily
FGM00_18615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FGM00_18620	COG0720	synthase
FGM00_18625	COG2226	methyltransferase
FGM00_18640	COG0534	Mate efflux family protein
FGM00_18675	COG4221	oxidoreductase activity
FGM00_18680	COG0210	DNA helicase
FGM00_18700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FGM00_18715	COG0328	RNA-DNA hybrid ribonuclease activity
FGM00_18715	COG3341	Caulimovirus viroplasmin
FGM00_18720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FGM00_18725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGM00_18730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FGM00_18735	COG0571	ribonuclease III activity
FGM00_18745	COG0469	pyruvate kinase activity
FGM00_18755	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FGM00_18760	COG2954	triphosphatase activity
FGM00_18775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FGM00_18780	COG0659	secondary active sulfate transmembrane transporter activity
FGM00_18790	COG0659	secondary active sulfate transmembrane transporter activity
FGM00_18815	COG2304	oxidoreductase activity
FGM00_18820	COG2304	oxidoreductase activity
FGM00_18835	COG0714	Associated with various cellular activities
FGM00_18840	COG4989	oxidoreductase activity
FGM00_18845	COG4221	oxidoreductase activity
FGM00_18855	COG1115	amino acid carrier protein
FGM00_18870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FGM00_18905	COG1012	belongs to the aldehyde dehydrogenase family
FGM00_18930	COG2373	Large extracellular alpha-helical protein
FGM00_18950	COG2329	Antibiotic biosynthesis monooxygenase
FGM00_18955	COG4953	penicillin-binding protein 1C
FGM00_18960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FGM00_18965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FGM00_18975	COG2323	membrane
FGM00_19000	COG0659	secondary active sulfate transmembrane transporter activity
FGM00_19010	COG0429	hydrolase of the alpha beta-hydrolase fold
FGM00_19015	COG3781	membrane
FGM00_19070	COG0626	cystathionine gamma-synthase activity
FGM00_19075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FGM00_19080	COG1381	Involved in DNA repair and RecF pathway recombination
FGM00_19085	COG4771	TonB-dependent receptor
FGM00_19095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FGM00_19110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FGM00_19115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FGM00_19120	COG0322	excinuclease ABC activity
FGM00_19125	COG1752	Esterase of the alpha-beta hydrolase superfamily
FGM00_19130	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FGM00_19150	COG0166	Belongs to the GPI family
FGM00_19185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FGM00_19195	COG4095	Psort location CytoplasmicMembrane, score
FGM00_19200	COG1051	belongs to the nudix hydrolase family
FGM00_19215	COG1040	competence protein
FGM00_19225	COG0423	glycine-tRNA ligase activity
FGM00_19245	COG0708	Exodeoxyribonuclease III
FGM00_19255	COG0667	Aldo Keto reductase
FGM00_19260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FGM00_19280	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FGM00_19285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FGM00_19290	COG0297	glycogen (starch) synthase activity
FGM00_19300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FGM00_19305	COG4771	TonB-dependent receptor
FGM00_19335	COG0156	8-amino-7-oxononanoate synthase activity
FGM00_19345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FGM00_19350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FGM00_19365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FGM00_19375	COG2137	regulation of response to DNA damage stimulus
FGM00_19380	COG1530	ribonuclease E activity
FGM00_19385	COG0776	regulation of translation
FGM00_19395	COG0629	single-stranded DNA binding
FGM00_19430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FGM00_19460	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FGM00_19465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FGM00_19480	COG0633	Ferredoxin
FGM00_19480	COG3217	Mosc domain protein beta barrel domain protein
FGM00_19500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FGM00_19505	COG2091	lysine biosynthetic process via aminoadipic acid
FGM00_19545	COG0784	Response regulator, receiver
FGM00_19545	COG2198	Histidine kinase
FGM00_19545	COG5002	protein histidine kinase activity
FGM00_19595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FGM00_19610	COG5000	phosphorelay sensor kinase activity
FGM00_19635	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FGM00_19640	COG0519	Catalyzes the synthesis of GMP from XMP
FGM00_19690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs