locus-tag	class	description
AGREI_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AGREI_0002	COG0592	DNA-directed DNA polymerase activity
AGREI_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AGREI_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AGREI_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AGREI_0006	COG0187	DNA topoisomerase II activity
AGREI_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AGREI_0008	COG3266	domain, Protein
AGREI_0012	COG0457	Tetratricopeptide repeat
AGREI_0012	COG0705	Rhomboid family
AGREI_0014	COG3764	Sortase (surface protein transpeptidase)
AGREI_0017	COG0515	serine threonine protein kinase
AGREI_0017	COG2815	serine threonine protein kinase
AGREI_0018	COG0515	serine threonine protein kinase
AGREI_0019	COG0768	penicillin binding
AGREI_0022	COG1716	ATPase activity
AGREI_0027	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AGREI_0028	COG0393	Putative heavy-metal-binding
AGREI_0032	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AGREI_0039	COG2814	Major facilitator Superfamily
AGREI_0041	COG2226	methyltransferase
AGREI_0044	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AGREI_0045	COG0738	Major facilitator superfamily
AGREI_0046	COG1609	Transcriptional regulator
AGREI_0056	COG0534	Mate efflux family protein
AGREI_0057	COG3590	peptidase
AGREI_0058	COG1609	Transcriptional regulator
AGREI_0061	COG0395	ABC-type sugar transport system, permease component
AGREI_0067	COG1597	lipid kinase activity
AGREI_0068	COG0583	DNA-binding transcription factor activity
AGREI_0074	COG0515	serine threonine protein kinase
AGREI_0078	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AGREI_0079	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AGREI_0081	COG0454	-acetyltransferase
AGREI_0086	COG3253	May function as heme-dependent peroxidase
AGREI_0087	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AGREI_0088	COG0181	hydroxymethylbilane synthase activity
AGREI_0090	COG0113	porphobilinogen synthase activity
AGREI_0091	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AGREI_0092	COG1302	Protein conserved in bacteria
AGREI_0093	COG1595	DNA-templated transcription, initiation
AGREI_0097	COG1902	pentaerythritol trinitrate reductase activity
AGREI_0104	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AGREI_0105	COG1054	Belongs to the UPF0176 family
AGREI_0107	COG1045	serine acetyltransferase
AGREI_0108	COG3458	cephalosporin-C deacetylase activity
AGREI_0109	COG0483	inositol monophosphate 1-phosphatase activity
AGREI_0110	COG3842	ATPase activity
AGREI_0111	COG3833	ABC-type maltose transport systems, permease component
AGREI_0114	COG1609	Transcriptional regulator
AGREI_0115	COG1174	glycine betaine transport
AGREI_0117	COG1174	glycine betaine transport
AGREI_0122	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AGREI_0123	COG1024	Enoyl-CoA hydratase
AGREI_0132	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_0136	COG2814	Major facilitator Superfamily
AGREI_0137	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AGREI_0142	COG3718	enzyme involved in inositol metabolism
AGREI_0143	COG3962	Belongs to the TPP enzyme family
AGREI_0146	COG1082	Xylose isomerase domain protein TIM barrel
AGREI_0147	COG1942	4-Oxalocrotonate Tautomerase
AGREI_0148	COG2188	Transcriptional regulator
AGREI_0149	COG1607	acyl-coa hydrolase
AGREI_0157	COG0586	Pfam SNARE associated Golgi protein
AGREI_0159	COG3012	SEC-C Motif Domain Protein
AGREI_0182	COG2197	response regulator
AGREI_0183	COG4585	Histidine kinase
AGREI_0184	COG0842	Transport permease protein
AGREI_0185	COG1131	(ABC) transporter
AGREI_0190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AGREI_0190	COG2755	lipolytic protein G-D-S-L family
AGREI_0191	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_0193	COG2130	NADP-dependent
AGREI_0195	COG0659	secondary active sulfate transmembrane transporter activity
AGREI_0203	COG4221	oxidoreductase activity
AGREI_0207	COG1609	Transcriptional regulator
AGREI_0212	COG1653	transport
AGREI_0213	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AGREI_0217	COG2354	Protein conserved in bacteria
AGREI_0218	COG2326	polyphosphate kinase activity
AGREI_0219	COG1725	Transcriptional regulator
AGREI_0220	COG2357	RelA SpoT domain protein
AGREI_0222	COG1834	amidinotransferase
AGREI_0223	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AGREI_0235	COG2814	Major facilitator Superfamily
AGREI_0236	COG2130	NADP-dependent
AGREI_0238	COG0277	FAD linked oxidase domain protein
AGREI_0239	COG0673	inositol 2-dehydrogenase activity
AGREI_0245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AGREI_0246	COG4585	Histidine kinase
AGREI_0247	COG2197	response regulator
AGREI_0252	COG1305	Transglutaminase-like
AGREI_0256	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AGREI_0263	COG1876	peptidase activity
AGREI_0267	COG0077	Prephenate dehydratase
AGREI_0270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AGREI_0271	COG0561	phosphatase activity
AGREI_0275	COG0277	FAD linked oxidase domain protein
AGREI_0276	COG1940	carbohydrate kinase activity
AGREI_0279	COG1879	ABC-type sugar transport system periplasmic component
AGREI_0280	COG1172	Belongs to the binding-protein-dependent transport system permease family
AGREI_0284	COG1072	(Pantothenic acid kinase))
AGREI_0289	COG0363	glucosamine-6-phosphate deaminase activity
AGREI_0290	COG0673	inositol 2-dehydrogenase activity
AGREI_0291	COG0673	inositol 2-dehydrogenase activity
AGREI_0293	COG1940	carbohydrate kinase activity
AGREI_0296	COG1175	transmembrane transport
AGREI_0310	COG0415	Belongs to the DNA photolyase family
AGREI_0318	COG1609	Transcriptional regulator
AGREI_0320	COG0640	Transcriptional regulator
AGREI_0321	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_0322	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_0323	COG4607	ABC-type enterochelin transport system periplasmic component
AGREI_0325	COG2308	Evidence 4 Homologs of previously reported genes of
AGREI_0325	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AGREI_0326	COG0745	RESPONSE REGULATOR receiver
AGREI_0327	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AGREI_0328	COG0590	tRNA wobble adenosine to inosine editing
AGREI_0330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AGREI_0333	COG0569	domain protein
AGREI_0334	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AGREI_0335	COG0640	Transcriptional regulator
AGREI_0337	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AGREI_0343	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AGREI_0347	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_0348	COG0785	Cytochrome C biogenesis protein
AGREI_0352	COG2267	carboxylic ester hydrolase activity
AGREI_0359	COG0573	inorganic phosphate transmembrane transporter activity
AGREI_0363	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AGREI_0366	COG0515	serine threonine protein kinase
AGREI_0366	COG2815	serine threonine protein kinase
AGREI_0369	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AGREI_0370	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_0371	COG0328	RNA-DNA hybrid ribonuclease activity
AGREI_0373	COG1846	Transcriptional regulator
AGREI_0374	COG1764	response to oxidative stress
AGREI_0382	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AGREI_0385	COG0596	Alpha beta hydrolase
AGREI_0386	COG2326	polyphosphate kinase activity
AGREI_0388	COG1169	isochorismate synthase
AGREI_0389	COG2226	methyltransferase
AGREI_0390	COG0142	geranyltranstransferase activity
AGREI_0393	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_0394	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_0395	COG1120	ATPase activity
AGREI_0398	COG0494	nUDIX hydrolase
AGREI_0399	COG1666	GTP binding
AGREI_0403	COG1196	nuclear chromosome segregation
AGREI_0403	COG0741	lytic transglycosylase activity
AGREI_0403	COG0739	heme binding
AGREI_0404	COG0366	Alpha amylase catalytic
AGREI_0406	COG0745	RESPONSE REGULATOR receiver
AGREI_0408	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AGREI_0410	COG2030	dehydratase
AGREI_0412	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AGREI_0425	COG1329	Transcriptional regulator
AGREI_0432	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_0451	COG1131	(ABC) transporter
AGREI_0459	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AGREI_0470	COG1609	Transcriptional regulator
AGREI_0471	COG1874	Beta-galactosidase
AGREI_0473	COG1175	transmembrane transport
AGREI_0474	COG0395	ABC-type sugar transport system, permease component
AGREI_0481	COG1609	Transcriptional regulator
AGREI_0482	COG1653	transport
AGREI_0483	COG1175	transmembrane transport
AGREI_0484	COG0395	ABC-type sugar transport system, permease component
AGREI_0485	COG1472	Belongs to the glycosyl hydrolase 3 family
AGREI_0500	COG3206	protein involved in exopolysaccharide biosynthesis
AGREI_0500	COG0489	protein tyrosine kinase activity
AGREI_0501	COG0297	glycogen (starch) synthase activity
AGREI_0504	COG3420	alginic acid biosynthetic process
AGREI_0507	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_0512	COG2755	lipolytic protein G-D-S-L family
AGREI_0513	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AGREI_0514	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AGREI_0537	COG0489	protein tyrosine kinase activity
AGREI_0538	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_0539	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_0544	COG0297	glycogen (starch) synthase activity
AGREI_0545	COG0438	transferase activity, transferring glycosyl groups
AGREI_0552	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AGREI_0553	COG1846	Transcriptional regulator
AGREI_0555	COG1316	TRANSCRIPTIONal
AGREI_0559	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AGREI_0563	COG1609	Transcriptional regulator
AGREI_0565	COG4213	ABC transporter substrate-binding protein
AGREI_0566	COG1129	ABC transporter
AGREI_0567	COG4214	carbohydrate transport
AGREI_0568	COG1129	ABC transporter
AGREI_0570	COG0588	phosphoglycerate mutase activity
AGREI_0574	COG0436	Aminotransferase
AGREI_0579	COG1088	dTDP-glucose 4,6-dehydratase activity
AGREI_0582	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AGREI_0583	COG0081	regulation of translation
AGREI_0585	COG0477	Major facilitator Superfamily
AGREI_0586	COG1309	transcriptional regulator
AGREI_0591	COG0604	alcohol dehydrogenase
AGREI_0591	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AGREI_0591	COG4221	oxidoreductase activity
AGREI_0591	COG3321	synthase
AGREI_0595	COG1136	(ABC) transporter
AGREI_0598	COG0745	RESPONSE REGULATOR receiver
AGREI_0599	COG2205	protein histidine kinase activity
AGREI_0600	COG1301	dicarboxylic acid transport
AGREI_0601	COG0823	Involved in the tonB-independent uptake of proteins
AGREI_0603	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AGREI_0604	COG0222	ribosome binding
AGREI_0606	COG1609	Transcriptional regulator
AGREI_0608	COG1653	transport
AGREI_0610	COG1175	transmembrane transport
AGREI_0611	COG0395	ABC-type sugar transport system, permease component
AGREI_0612	COG1132	(ABC) transporter
AGREI_0616	COG0686	Belongs to the AlaDH PNT family
AGREI_0618	COG4946	Tricorn protease homolog
AGREI_0618	COG1506	peptidase
AGREI_0618	COG0823	Involved in the tonB-independent uptake of proteins
AGREI_0622	COG1780	Probably involved in ribonucleotide reductase function
AGREI_0623	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AGREI_0624	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AGREI_0625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AGREI_0627	COG0477	Major facilitator Superfamily
AGREI_0628	COG1733	regulation of RNA biosynthetic process
AGREI_0629	COG0702	epimerase
AGREI_0630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AGREI_0631	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_0632	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AGREI_0633	COG0406	alpha-ribazole phosphatase activity
AGREI_0635	COG1464	Belongs to the NlpA lipoprotein family
AGREI_0636	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AGREI_0637	COG2011	ABC-type metal ion transport system permease component
AGREI_0639	COG0765	amino acid transport
AGREI_0640	COG1126	abc transporter atp-binding protein
AGREI_0641	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_0643	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_0644	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_0652	COG1609	Transcriptional regulator
AGREI_0655	COG2160	L-arabinose isomerase activity
AGREI_0659	COG1129	ABC transporter
AGREI_0660	COG4214	carbohydrate transport
AGREI_0662	COG1070	Carbohydrate kinase
AGREI_0663	COG2115	Belongs to the xylose isomerase family
AGREI_0665	COG4213	ABC transporter substrate-binding protein
AGREI_0666	COG1129	ABC transporter
AGREI_0667	COG4214	carbohydrate transport
AGREI_0668	COG1940	carbohydrate kinase activity
AGREI_0669	COG1940	carbohydrate kinase activity
AGREI_0669	COG1846	Transcriptional regulator
AGREI_0670	COG2814	Major facilitator Superfamily
AGREI_0675	COG0395	ABC-type sugar transport system, permease component
AGREI_0676	COG3534	alpha-L-arabinofuranosidase
AGREI_0678	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_0679	COG0433	COG0433 Predicted ATPase
AGREI_0682	COG0667	Aldo Keto reductase
AGREI_0683	COG2815	serine threonine protein kinase
AGREI_0683	COG0515	serine threonine protein kinase
AGREI_0690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AGREI_0694	COG1971	Probably functions as a manganese efflux pump
AGREI_0696	COG4221	oxidoreductase activity
AGREI_0703	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_0704	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_0709	COG0702	epimerase
AGREI_0715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AGREI_0718	COG0456	acetyltransferase
AGREI_0720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AGREI_0729	COG0579	oxidoreductase
AGREI_0736	COG1435	thymidine kinase activity
AGREI_0739	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AGREI_0742	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AGREI_0750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AGREI_0750	COG1754	DNA topoisomerase type I activity
AGREI_0751	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AGREI_0752	COG0470	DNA polymerase III
AGREI_0757	COG1335	isochorismatase
AGREI_0758	COG2409	Drug exporters of the RND superfamily
AGREI_0760	COG1132	(ABC) transporter
AGREI_0761	COG0477	Major facilitator Superfamily
AGREI_0762	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AGREI_0763	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AGREI_0764	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AGREI_0764	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AGREI_0767	COG1216	Glycosyl transferase, family 2
AGREI_0771	COG0180	Tryptophanyl-tRNA synthetase
AGREI_0774	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AGREI_0775	COG1053	succinate dehydrogenase
AGREI_0777	COG2009	succinate dehydrogenase
AGREI_0778	COG0438	transferase activity, transferring glycosyl groups
AGREI_0780	COG1744	ABC transporter substrate-binding protein PnrA-like
AGREI_0782	COG3845	ABC transporter
AGREI_0783	COG4603	Belongs to the binding-protein-dependent transport system permease family
AGREI_0784	COG1079	Belongs to the binding-protein-dependent transport system permease family
AGREI_0792	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AGREI_0795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AGREI_0798	COG4770	biotin carboxylase activity
AGREI_0799	COG0424	maF-like protein
AGREI_0800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AGREI_0805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AGREI_0809	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AGREI_0810	COG1316	TRANSCRIPTIONal
AGREI_0821	COG1216	Glycosyl transferase, family 2
AGREI_0844	COG1960	acyl-CoA dehydrogenase activity
AGREI_0845	COG1482	cell wall glycoprotein biosynthetic process
AGREI_0848	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AGREI_0855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AGREI_0861	COG0714	Associated with various cellular activities
AGREI_0865	COG0745	RESPONSE REGULATOR receiver
AGREI_0866	COG5002	protein histidine kinase activity
AGREI_0866	COG5000	phosphorelay sensor kinase activity
AGREI_0868	COG1040	competence protein
AGREI_0869	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AGREI_0870	COG0653	protein targeting
AGREI_0882	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AGREI_0883	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_0884	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AGREI_0889	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AGREI_0890	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_0891	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_0892	COG2188	Transcriptional regulator
AGREI_0894	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AGREI_0896	COG0129	dihydroxy-acid dehydratase activity
AGREI_0897	COG0028	Belongs to the TPP enzyme family
AGREI_0898	COG0440	acetolactate synthase activity
AGREI_0899	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AGREI_0908	COG0477	Major facilitator Superfamily
AGREI_0911	COG0473	3-isopropylmalate dehydrogenase activity
AGREI_0912	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AGREI_0914	COG0179	Fumarylacetoacetate (FAA) hydrolase
AGREI_0915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AGREI_0916	COG0492	ferredoxin-NADP+ reductase activity
AGREI_0919	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AGREI_0924	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AGREI_0939	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AGREI_0940	COG0066	3-isopropylmalate dehydratase activity
AGREI_0941	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AGREI_0943	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AGREI_0944	COG1181	Belongs to the D-alanine--D-alanine ligase family
AGREI_0945	COG1716	ATPase activity
AGREI_0947	COG0631	protein serine/threonine phosphatase activity
AGREI_0950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_0952	COG0464	growth
AGREI_0955	COG0598	Magnesium transport protein CorA
AGREI_0958	COG0742	ribosomal rna small subunit methyltransferase
AGREI_0959	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AGREI_0960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AGREI_0967	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_0979	COG0456	acetyltransferase
AGREI_0985	COG0477	Major facilitator Superfamily
AGREI_0994	COG0488	(ABC) transporter
AGREI_0995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AGREI_0996	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_0997	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AGREI_0997	COG0778	Nitroreductase
AGREI_0998	COG1920	GTP binding
AGREI_1001	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AGREI_1006	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_1008	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_1010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_1013	COG0583	DNA-binding transcription factor activity
AGREI_1015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AGREI_1016	COG0571	ribonuclease III activity
AGREI_1017	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_1020	COG3619	membrane
AGREI_1023	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AGREI_1040	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_1042	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_1045	COG0259	pyridoxamine-phosphate oxidase activity
AGREI_1049	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AGREI_1051	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_1055	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_1056	COG1335	isochorismatase
AGREI_1061	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_1062	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AGREI_1062	COG3608	succinylglutamate desuccinylase aspartoacylase
AGREI_1066	COG0314	molybdopterin synthase activity
AGREI_1067	COG0521	Mo-molybdopterin cofactor biosynthetic process
AGREI_1076	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AGREI_1077	COG2318	DinB family
AGREI_1080	COG4251	negative regulation of phosphorylation
AGREI_1081	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AGREI_1082	COG1196	nuclear chromosome segregation
AGREI_1083	COG0321	lipoyl(octanoyl) transferase activity
AGREI_1084	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AGREI_1086	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_1087	COG2814	Major facilitator Superfamily
AGREI_1092	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AGREI_1094	COG0228	four-way junction DNA binding
AGREI_1095	COG1837	Belongs to the UPF0109 family
AGREI_1096	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AGREI_1099	COG0336	Belongs to the RNA methyltransferase TrmD family
AGREI_1102	COG0335	large ribosomal subunit rRNA binding
AGREI_1104	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AGREI_1108	COG0792	nuclease activity
AGREI_1111	COG0702	epimerase
AGREI_1115	COG0395	ABC-type sugar transport system, permease component
AGREI_1118	COG4974	Belongs to the 'phage' integrase family
AGREI_1120	COG0477	Major facilitator Superfamily
AGREI_1123	COG0052	Belongs to the universal ribosomal protein uS2 family
AGREI_1124	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AGREI_1126	COG0528	UMP kinase activity
AGREI_1127	COG0233	cytoplasmic translational termination
AGREI_1138	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AGREI_1139	COG0366	Alpha amylase catalytic
AGREI_1141	COG0058	SHG alpha-glucan phosphorylase activity
AGREI_1147	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_1149	COG0482	sulfurtransferase activity
AGREI_1150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AGREI_1151	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AGREI_1152	COG0154	amidase activity
AGREI_1153	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AGREI_1157	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_1159	COG1755	Isoprenylcysteine carboxyl methyltransferase
AGREI_1162	COG0667	Aldo Keto reductase
AGREI_1164	COG0706	membrane insertase activity
AGREI_1166	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AGREI_1172	COG4721	ABC-type cobalt transport system, permease component
AGREI_1173	COG1122	ATPase activity
AGREI_1179	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AGREI_1184	COG1017	nitric oxide dioxygenase activity
AGREI_1184	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AGREI_1187	COG0667	Aldo Keto reductase
AGREI_1192	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AGREI_1193	COG1946	Acyl-CoA thioesterase
AGREI_1196	COG0668	transmembrane transport
AGREI_1200	COG2808	Putative FMN-binding domain
AGREI_1201	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_1203	COG2326	polyphosphate kinase activity
AGREI_1204	COG0783	Belongs to the Dps family
AGREI_1206	COG0544	peptidyl-prolyl cis-trans isomerase activity
AGREI_1210	COG2733	membrane
AGREI_1211	COG0740	serine-type endopeptidase activity
AGREI_1212	COG0740	serine-type endopeptidase activity
AGREI_1213	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AGREI_1214	COG3135	benzoate transporter
AGREI_1219	COG0525	valine-tRNA ligase activity
AGREI_1220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AGREI_1223	COG0747	negative chemotaxis
AGREI_1224	COG0601	transmembrane transport
AGREI_1225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_1230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AGREI_1231	COG0285	dihydrofolate synthase activity
AGREI_1233	COG0105	UTP biosynthetic process
AGREI_1235	COG1530	ribonuclease E activity
AGREI_1237	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AGREI_1238	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AGREI_1239	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AGREI_1240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AGREI_1241	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AGREI_1243	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AGREI_1245	COG0799	negative regulation of ribosome biogenesis
AGREI_1247	COG1309	transcriptional regulator
AGREI_1248	COG0477	Major facilitator Superfamily
AGREI_1254	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AGREI_1255	COG2353	YceI-like domain
AGREI_1256	COG2267	carboxylic ester hydrolase activity
AGREI_1258	COG0587	DNA-directed DNA polymerase activity
AGREI_1261	COG2197	response regulator
AGREI_1265	COG1125	glycine betaine transport
AGREI_1265	COG0517	IMP dehydrogenase activity
AGREI_1266	COG1174	glycine betaine transport
AGREI_1267	COG1174	glycine betaine transport
AGREI_1269	COG0586	Pfam SNARE associated Golgi protein
AGREI_1272	COG1271	oxidase subunit
AGREI_1273	COG1294	oxidase, subunit
AGREI_1274	COG4988	ABC transporter
AGREI_1275	COG1132	(ABC) transporter
AGREI_1278	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_1280	COG0495	leucyl-tRNA aminoacylation
AGREI_1281	COG1555	photosystem II stabilization
AGREI_1281	COG1596	polysaccharide export
AGREI_1284	COG0268	Binds directly to 16S ribosomal RNA
AGREI_1287	COG0481	GTPase activity
AGREI_1292	COG1420	regulation of RNA biosynthetic process
AGREI_1293	COG0484	heat shock protein binding
AGREI_1295	COG0537	adenosine 5'-monophosphoramidase activity
AGREI_1297	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AGREI_1299	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AGREI_1300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AGREI_1301	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AGREI_1303	COG1674	ftsk spoiiie
AGREI_1305	COG1058	Belongs to the CinA family
AGREI_1305	COG1546	Belongs to the CinA family
AGREI_1307	COG1396	sequence-specific DNA binding
AGREI_1309	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AGREI_1311	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AGREI_1312	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AGREI_1313	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AGREI_1314	COG2813	Specifically methylates the guanine in position
AGREI_1315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AGREI_1316	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AGREI_1318	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AGREI_1319	COG0131	Imidazoleglycerol-phosphate dehydratase
AGREI_1320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AGREI_1321	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AGREI_1324	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AGREI_1325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AGREI_1326	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AGREI_1327	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_1328	COG1126	abc transporter atp-binding protein
AGREI_1329	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_1330	COG0765	amino acid transport
AGREI_1331	COG0765	amino acid transport
AGREI_1332	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AGREI_1333	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AGREI_1333	COG0072	phenylalanine-tRNA ligase activity
AGREI_1334	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AGREI_1335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AGREI_1336	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AGREI_1338	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AGREI_1339	COG0165	Argininosuccinate lyase
AGREI_1340	COG2094	Belongs to the DNA glycosylase MPG family
AGREI_1343	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AGREI_1354	COG0647	UMP catabolic process
AGREI_1356	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AGREI_1357	COG0497	DNA recombination
AGREI_1358	COG0504	CTP synthase activity
AGREI_1359	COG0494	nUDIX hydrolase
AGREI_1362	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AGREI_1363	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AGREI_1366	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AGREI_1367	COG1160	GTP binding
AGREI_1375	COG1175	transmembrane transport
AGREI_1378	COG0248	Ppx GppA phosphatase
AGREI_1381	COG1695	Transcriptional regulator
AGREI_1382	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AGREI_1385	COG1064	alcohol dehydrogenase
AGREI_1387	COG2315	Protein conserved in bacteria
AGREI_1389	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_1394	COG1793	dna ligase
AGREI_1398	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
AGREI_1405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AGREI_1411	COG1716	ATPase activity
AGREI_1415	COG1192	Involved in chromosome partitioning
AGREI_1416	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AGREI_1422	COG1940	carbohydrate kinase activity
AGREI_1423	COG0204	Acyl-transferase
AGREI_1424	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AGREI_1425	COG2815	serine threonine protein kinase
AGREI_1425	COG0515	serine threonine protein kinase
AGREI_1426	COG1134	teichoic acid transport
AGREI_1426	COG1388	LysM domain
AGREI_1428	COG0142	geranyltranstransferase activity
AGREI_1430	COG2001	Belongs to the MraZ family
AGREI_1431	COG0275	rRNA processing
AGREI_1433	COG0768	penicillin binding
AGREI_1434	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AGREI_1436	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AGREI_1437	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AGREI_1439	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AGREI_1440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AGREI_1442	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AGREI_1444	COG1799	cell septum assembly
AGREI_1446	COG3599	regulation of cell shape
AGREI_1447	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AGREI_1449	COG0587	DNA-directed DNA polymerase activity
AGREI_1451	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AGREI_1452	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AGREI_1453	COG0167	dihydroorotate dehydrogenase activity
AGREI_1458	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AGREI_1459	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AGREI_1462	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AGREI_1463	COG0723	plastoquinol--plastocyanin reductase activity
AGREI_1464	COG2010	Cytochrome c
AGREI_1465	COG1845	cytochrome c oxidase, subunit III
AGREI_1466	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AGREI_1467	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AGREI_1468	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AGREI_1469	COG2376	Dihydroxyacetone kinase
AGREI_1470	COG1461	Dihydroxyacetone kinase
AGREI_1472	COG1051	belongs to the nudix hydrolase family
AGREI_1473	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_1476	COG0584	glycerophosphoryl diester phosphodiesterase
AGREI_1480	COG0805	protein transport
AGREI_1481	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_1487	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AGREI_1489	COG0215	cysteine-tRNA ligase activity
AGREI_1490	COG1968	undecaprenyl-diphosphatase activity
AGREI_1491	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_1492	COG1278	Cold shock
AGREI_1500	COG0406	alpha-ribazole phosphatase activity
AGREI_1503	COG0366	Alpha amylase catalytic
AGREI_1505	COG0254	rRNA binding
AGREI_1506	COG1119	ATPase activity
AGREI_1507	COG0297	glycogen (starch) synthase activity
AGREI_1508	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AGREI_1509	COG0560	Phosphoserine phosphatase
AGREI_1510	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_1512	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AGREI_1513	COG1122	ATPase activity
AGREI_1514	COG0183	Belongs to the thiolase family
AGREI_1516	COG1268	BioY protein
AGREI_1518	COG0488	(ABC) transporter
AGREI_1519	COG2151	metal-sulfur cluster biosynthetic enzyme
AGREI_1520	COG0396	ATPase activity
AGREI_1521	COG2146	nitrite reductase [NAD(P)H] activity
AGREI_1524	COG1612	heme a metabolic process
AGREI_1525	COG0109	protoheme IX farnesyltransferase activity
AGREI_1526	COG4702	Belongs to the UPF0303 family
AGREI_1528	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AGREI_1531	COG0363	glucosamine-6-phosphate deaminase activity
AGREI_1533	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AGREI_1534	COG0149	triose-phosphate isomerase activity
AGREI_1535	COG0126	phosphoglycerate kinase activity
AGREI_1536	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AGREI_1537	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AGREI_1538	COG1481	regulation of sporulation
AGREI_1539	COG1660	Displays ATPase and GTPase activities
AGREI_1540	COG0322	excinuclease ABC activity
AGREI_1542	COG0556	nucleotide-excision repair
AGREI_1544	COG0237	dephospho-CoA kinase activity
AGREI_1549	COG2050	protein possibly involved in aromatic compounds catabolism
AGREI_1554	COG0469	pyruvate kinase activity
AGREI_1556	COG0070	glutamate synthase
AGREI_1556	COG0069	glutamate synthase activity
AGREI_1556	COG0067	glutamate synthase
AGREI_1557	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AGREI_1558	COG0159	tryptophan synthase activity
AGREI_1559	COG0133	tryptophan synthase activity
AGREI_1560	COG0134	indole-3-glycerol-phosphate synthase activity
AGREI_1565	COG0107	imidazoleglycerol-phosphate synthase activity
AGREI_1566	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AGREI_1570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AGREI_1572	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AGREI_1574	COG1758	RNA polymerase activity
AGREI_1575	COG0194	GDP metabolic process
AGREI_1576	COG0284	orotidine-5'-phosphate decarboxylase activity
AGREI_1577	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AGREI_1578	COG0505	Belongs to the CarA family
AGREI_1580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AGREI_1581	COG0540	Belongs to the ATCase OTCase family
AGREI_1582	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AGREI_1583	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AGREI_1584	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AGREI_1585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AGREI_1587	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AGREI_1588	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AGREI_1589	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AGREI_1590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AGREI_1592	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AGREI_1593	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AGREI_1597	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AGREI_1601	COG1196	nuclear chromosome segregation
AGREI_1603	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AGREI_1604	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AGREI_1605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AGREI_1607	COG2255	four-way junction helicase activity
AGREI_1608	COG0632	four-way junction helicase activity
AGREI_1609	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AGREI_1610	COG0217	transcriptional regulatory protein
AGREI_1611	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AGREI_1612	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AGREI_1614	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AGREI_1616	COG3591	Belongs to the peptidase S1B family
AGREI_1616	COG1864	DNA RNA non-specific endonuclease
AGREI_1618	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_1619	COG2814	Major facilitator Superfamily
AGREI_1622	COG3387	PFAM Glycoside hydrolase 15-related
AGREI_1623	COG0783	Belongs to the Dps family
AGREI_1631	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AGREI_1632	COG0183	Belongs to the thiolase family
AGREI_1633	COG1024	Enoyl-CoA hydratase
AGREI_1633	COG1250	3-hydroxyacyl-CoA dehydrogenase
AGREI_1634	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AGREI_1635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AGREI_1638	COG0756	dUTP diphosphatase activity
AGREI_1643	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AGREI_1645	COG0187	DNA topoisomerase II activity
AGREI_1646	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_1647	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_1650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AGREI_1652	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AGREI_1653	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AGREI_1654	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_1655	COG0515	serine threonine protein kinase
AGREI_1655	COG2815	serine threonine protein kinase
AGREI_1658	COG0174	glutamine synthetase
AGREI_1660	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AGREI_1661	COG0174	glutamine synthetase
AGREI_1663	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AGREI_1667	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AGREI_1672	COG4974	Belongs to the 'phage' integrase family
AGREI_1680	COG5297	Belongs to the glycosyl hydrolase family 6
AGREI_1728	COG0450	alkyl hydroperoxide reductase
AGREI_1729	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AGREI_1733	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AGREI_1734	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AGREI_1735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AGREI_1740	COG0714	Associated with various cellular activities
AGREI_1742	COG0438	transferase activity, transferring glycosyl groups
AGREI_1744	COG0242	peptide deformylase activity
AGREI_1750	COG0601	transmembrane transport
AGREI_1756	COG0442	prolyl-tRNA aminoacylation
AGREI_1758	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AGREI_1759	COG1381	Involved in DNA repair and RecF pathway recombination
AGREI_1760	COG2860	membrane
AGREI_1761	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AGREI_1765	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AGREI_1768	COG0612	Peptidase, M16
AGREI_1769	COG1185	polyribonucleotide nucleotidyltransferase activity
AGREI_1776	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AGREI_1780	COG0545	Peptidyl-prolyl cis-trans isomerase
AGREI_1783	COG0277	FAD linked oxidase domain protein
AGREI_1786	COG3281	Trehalose synthase
AGREI_1789	COG0438	transferase activity, transferring glycosyl groups
AGREI_1790	COG0598	Magnesium transport protein CorA
AGREI_1791	COG0435	Glutathione S-transferase
AGREI_1792	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AGREI_1794	COG1090	epimerase
AGREI_1799	COG0702	epimerase
AGREI_1802	COG0196	riboflavin kinase activity
AGREI_1805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AGREI_1812	COG1194	a g-specific adenine glycosylase
AGREI_1813	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AGREI_1814	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AGREI_1815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AGREI_1815	COG3266	domain, Protein
AGREI_1816	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AGREI_1818	COG0195	Participates in both transcription termination and antitermination
AGREI_1819	COG0442	prolyl-tRNA aminoacylation
AGREI_1820	COG1316	TRANSCRIPTIONal
AGREI_1826	COG0714	Associated with various cellular activities
AGREI_1827	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AGREI_1828	COG2197	response regulator
AGREI_1829	COG4585	Histidine kinase
AGREI_1830	COG0750	zinc metalloprotease
AGREI_1831	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AGREI_1836	COG2091	lysine biosynthetic process via aminoadipic acid
AGREI_1838	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AGREI_1842	COG0631	protein serine/threonine phosphatase activity
AGREI_1845	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_1847	COG3022	response to hydroperoxide
AGREI_1848	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AGREI_1849	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AGREI_1850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AGREI_1851	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AGREI_1852	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AGREI_1853	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AGREI_1854	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AGREI_1855	COG0356	it plays a direct role in the translocation of protons across the membrane
AGREI_1857	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AGREI_1860	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_1861	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AGREI_1863	COG0083	homoserine kinase activity
AGREI_1865	COG0460	homoserine dehydrogenase
AGREI_1869	COG0018	arginyl-trna synthetase
AGREI_1870	COG1305	Transglutaminase-like
AGREI_1871	COG0028	Belongs to the TPP enzyme family
AGREI_1877	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AGREI_1879	COG1842	Phage shock protein A
AGREI_1880	COG0010	Belongs to the arginase family
AGREI_1881	COG1024	Enoyl-CoA hydratase
AGREI_1887	COG4552	Acetyltransferase involved in intracellular survival and related
AGREI_1891	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AGREI_1893	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AGREI_1897	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AGREI_1909	COG0567	Dehydrogenase, E1 component
AGREI_1909	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_1911	COG1595	DNA-templated transcription, initiation
AGREI_1912	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AGREI_1914	COG0483	inositol monophosphate 1-phosphatase activity
AGREI_1915	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AGREI_1919	COG0438	transferase activity, transferring glycosyl groups
AGREI_1920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AGREI_1923	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AGREI_1924	COG2177	Part of the ABC transporter FtsEX involved in
AGREI_1925	COG2884	Cell division ATP-binding protein ftsE
AGREI_1926	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AGREI_1928	COG0477	Major facilitator Superfamily
AGREI_1937	COG1136	(ABC) transporter
AGREI_1938	COG4585	Histidine kinase
AGREI_1939	COG2197	response regulator
AGREI_1940	COG0586	Pfam SNARE associated Golgi protein
AGREI_1943	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AGREI_1944	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AGREI_1945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AGREI_1946	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AGREI_1955	COG2807	transmembrane transport
AGREI_1958	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_1959	COG0667	Aldo Keto reductase
AGREI_1961	COG0477	Major facilitator Superfamily
AGREI_1962	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_1963	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AGREI_1972	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AGREI_1978	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AGREI_1979	COG1940	carbohydrate kinase activity
AGREI_1979	COG1846	Transcriptional regulator
AGREI_1981	COG1653	transport
AGREI_1982	COG1175	transmembrane transport
AGREI_1983	COG0395	ABC-type sugar transport system, permease component
AGREI_1984	COG0366	Alpha amylase catalytic
AGREI_1985	COG2079	MmgE PrpD family protein
AGREI_1986	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AGREI_1987	COG1309	transcriptional regulator
AGREI_1989	COG2017	converts alpha-aldose to the beta-anomer
AGREI_1990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AGREI_1991	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AGREI_1992	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AGREI_1995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AGREI_2001	COG0395	ABC-type sugar transport system, permease component
AGREI_2004	COG1609	Transcriptional regulator
AGREI_2005	COG1615	UPF0182 protein
AGREI_2006	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AGREI_2018	COG0513	Belongs to the DEAD box helicase family
AGREI_2020	COG0006	proline dipeptidase activity
AGREI_2022	COG2239	Acts as a magnesium transporter
AGREI_2026	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AGREI_2029	COG0697	spore germination
AGREI_2032	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_2036	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_2037	COG2171	N-acyltransferase activity
AGREI_2038	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AGREI_2043	COG0672	)-iron permease
AGREI_2044	COG2822	iron ion transport
AGREI_2045	COG2837	iron assimilation
AGREI_2046	COG1217	gtp-binding protein TYPA
AGREI_2048	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_2049	COG0601	transmembrane transport
AGREI_2050	COG4166	transmembrane transport
AGREI_2054	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AGREI_2054	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AGREI_2055	COG0509	glycine decarboxylation via glycine cleavage system
AGREI_2056	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AGREI_2060	COG0488	(ABC) transporter
AGREI_2061	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AGREI_2062	COG2267	carboxylic ester hydrolase activity
AGREI_2063	COG0012	GTP binding
AGREI_2066	COG1322	Protein conserved in bacteria
AGREI_2068	COG0191	fructose-bisphosphate aldolase activity
AGREI_2070	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AGREI_2071	COG1570	exodeoxyribonuclease VII activity
AGREI_2072	COG1722	exodeoxyribonuclease VII activity
AGREI_2075	COG0114	fumarate hydratase activity
AGREI_2077	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AGREI_2079	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AGREI_2084	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AGREI_2086	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AGREI_2088	COG3842	ATPase activity
AGREI_2092	COG3214	Protein conserved in bacteria
AGREI_2093	COG0501	Belongs to the peptidase M48B family
AGREI_2094	COG1704	LemA family
AGREI_2099	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AGREI_2100	COG0514	ATP-dependent DNA helicase (RecQ)
AGREI_2101	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AGREI_2105	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AGREI_2106	COG2409	Drug exporters of the RND superfamily
AGREI_2114	COG0148	phosphopyruvate hydratase activity
AGREI_2117	COG0124	histidyl-tRNA synthetase
AGREI_2122	COG0193	aminoacyl-tRNA hydrolase activity
AGREI_2123	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AGREI_2126	COG0583	DNA-binding transcription factor activity
AGREI_2127	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AGREI_2128	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AGREI_2131	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AGREI_2132	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AGREI_2136	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AGREI_2137	COG1309	transcriptional regulator
AGREI_2138	COG3321	synthase
AGREI_2138	COG0604	alcohol dehydrogenase
AGREI_2139	COG3409	Peptidoglycan-binding domain 1 protein
AGREI_2142	COG0137	argininosuccinate synthase activity
AGREI_2143	COG0488	(ABC) transporter
AGREI_2144	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AGREI_2145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AGREI_2147	COG1131	(ABC) transporter
AGREI_2148	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AGREI_2150	COG1079	Belongs to the binding-protein-dependent transport system permease family
AGREI_2151	COG4603	Belongs to the binding-protein-dependent transport system permease family
AGREI_2152	COG3845	ABC transporter
AGREI_2153	COG1744	ABC transporter substrate-binding protein PnrA-like
AGREI_2154	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AGREI_2155	COG0084	hydrolase, TatD family'
AGREI_2156	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AGREI_2160	COG2855	membrane
AGREI_2163	COG1132	(ABC) transporter
AGREI_2168	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AGREI_2169	COG1760	l-serine dehydratase
AGREI_2172	COG1349	DNA-binding transcription factor activity
AGREI_2174	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AGREI_2175	COG1331	Highly conserved protein containing a thioredoxin domain
AGREI_2177	COG2986	histidine ammonia-lyase
AGREI_2184	COG1011	Hydrolase
AGREI_2186	COG1643	Atp-dependent helicase
AGREI_2189	COG2723	6-phospho-beta-galactosidase activity
AGREI_2190	COG0596	Alpha beta hydrolase
AGREI_2193	COG0601	transmembrane transport
AGREI_2194	COG4166	transmembrane transport
AGREI_2200	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AGREI_2206	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_2219	COG0587	DNA-directed DNA polymerase activity
AGREI_2220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_2223	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
AGREI_2241	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AGREI_2243	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AGREI_2245	COG3237	CsbD-like
AGREI_2248	COG1126	abc transporter atp-binding protein
AGREI_2249	COG0765	amino acid transport
AGREI_2250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_2251	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AGREI_2252	COG2072	flavoprotein involved in K transport
AGREI_2254	COG0438	transferase activity, transferring glycosyl groups
AGREI_2255	COG3537	Alpha-1,2-mannosidase
AGREI_2257	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_2258	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_2259	COG1120	ATPase activity
AGREI_2263	COG3639	organic phosphonate transmembrane transporter activity
AGREI_2265	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AGREI_2272	COG0515	serine threonine protein kinase
AGREI_2272	COG2815	serine threonine protein kinase
AGREI_2282	COG1321	iron dependent repressor
AGREI_2283	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AGREI_2285	COG1278	Cold shock
AGREI_2290	COG0745	RESPONSE REGULATOR receiver
AGREI_2291	COG2205	protein histidine kinase activity
AGREI_2293	COG0459	protein refolding
AGREI_2298	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AGREI_2300	COG2814	Major facilitator Superfamily
AGREI_2303	COG3842	ATPase activity
AGREI_2305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_2306	COG0215	cysteine-tRNA ligase activity
AGREI_2307	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AGREI_2307	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AGREI_2308	COG1329	Transcriptional regulator
AGREI_2311	COG5002	protein histidine kinase activity
AGREI_2313	COG0588	phosphoglycerate mutase activity
AGREI_2316	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AGREI_2317	COG3485	protocatechuate 3,4-dioxygenase
AGREI_2320	COG0745	RESPONSE REGULATOR receiver
AGREI_2321	COG0456	acetyltransferase
AGREI_2322	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AGREI_2327	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AGREI_2340	COG2017	converts alpha-aldose to the beta-anomer
AGREI_2341	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AGREI_2342	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AGREI_2348	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AGREI_2353	COG1132	(ABC) transporter
AGREI_2354	COG1132	(ABC) transporter
AGREI_2356	COG1834	amidinotransferase
AGREI_2357	COG0138	bifunctional purine biosynthesis protein purh
AGREI_2362	COG0045	succinate-CoA ligase (ADP-forming) activity
AGREI_2368	COG0584	glycerophosphoryl diester phosphodiesterase
AGREI_2371	COG0519	Catalyzes the synthesis of GMP from XMP
AGREI_2371	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AGREI_2374	COG0475	glutathione-regulated potassium exporter activity
AGREI_2376	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AGREI_2377	COG0516	GMP reductase activity
AGREI_2385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AGREI_2389	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AGREI_2390	COG0456	acetyltransferase
AGREI_2392	COG0802	atpase or kinase
AGREI_2393	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_2394	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AGREI_2395	COG0736	holo-[acyl-carrier-protein] synthase activity
AGREI_2396	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AGREI_2397	COG1072	(Pantothenic acid kinase))
AGREI_2398	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AGREI_2399	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AGREI_2400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AGREI_2401	COG0101	tRNA pseudouridine synthase activity
AGREI_2402	COG0203	ribosomal protein L17
AGREI_2403	COG0202	RNA polymerase activity
AGREI_2404	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AGREI_2405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AGREI_2406	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AGREI_2407	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AGREI_2409	COG0246	Mannitol dehydrogenase
AGREI_2412	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AGREI_2415	COG3711	transcriptional antiterminator
AGREI_2417	COG0563	adenylate kinase activity
AGREI_2420	COG0200	Binds to the 23S rRNA
AGREI_2421	COG1841	ribosomal large subunit assembly
AGREI_2422	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AGREI_2423	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AGREI_2424	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AGREI_2425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AGREI_2426	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AGREI_2427	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AGREI_2428	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AGREI_2429	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AGREI_2431	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AGREI_2433	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AGREI_2434	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AGREI_2435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AGREI_2436	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AGREI_2437	COG0089	rRNA binding
AGREI_2438	COG0088	Forms part of the polypeptide exit tunnel
AGREI_2439	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AGREI_2440	COG0051	transcription antitermination factor activity, RNA binding
AGREI_2444	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AGREI_2446	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AGREI_2447	COG0049	tRNA binding
AGREI_2448	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AGREI_2454	COG0714	Associated with various cellular activities
AGREI_2462	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AGREI_2463	COG0085	RNA polymerase activity
AGREI_2478	COG1201	RNA secondary structure unwinding
AGREI_2479	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AGREI_2480	COG1937	Protein conserved in bacteria
AGREI_2482	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AGREI_2484	COG0583	DNA-binding transcription factor activity
AGREI_2492	COG5006	permease, DMT superfamily
AGREI_2493	COG0277	FAD linked oxidase domain protein
AGREI_2495	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_2503	COG0395	ABC-type sugar transport system, permease component
AGREI_2504	COG1175	transmembrane transport
AGREI_2509	COG1609	Transcriptional regulator
AGREI_2510	COG1621	beta-fructofuranosidase activity
AGREI_2515	COG1609	Transcriptional regulator
AGREI_2516	COG0252	asparaginase activity
AGREI_2538	COG3293	Transposase
AGREI_2554	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_2565	COG0446	pyridine nucleotide-disulphide oxidoreductase
AGREI_2567	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AGREI_2576	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AGREI_2582	COG0739	heme binding
AGREI_2582	COG1196	nuclear chromosome segregation
AGREI_2582	COG0741	lytic transglycosylase activity
AGREI_2592	COG0785	Cytochrome C biogenesis protein
AGREI_2593	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AGREI_2601	COG4974	Belongs to the 'phage' integrase family
AGREI_2605	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AGREI_2606	COG2272	Belongs to the type-B carboxylesterase lipase family
AGREI_2615	COG1051	belongs to the nudix hydrolase family
AGREI_2616	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AGREI_2620	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_2626	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AGREI_2629	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AGREI_2632	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AGREI_2637	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AGREI_2639	COG0302	gtp cyclohydrolase
AGREI_2640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AGREI_2642	COG0037	tRNA processing
AGREI_2643	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AGREI_2644	COG0739	heme binding
AGREI_2645	COG0588	phosphoglycerate mutase activity
AGREI_2658	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AGREI_2660	COG1129	ABC transporter
AGREI_2661	COG4214	carbohydrate transport
AGREI_2665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AGREI_2665	COG0235	Class ii aldolase
AGREI_2666	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AGREI_2667	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AGREI_2668	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AGREI_2671	COG2197	response regulator
AGREI_2672	COG4585	Histidine kinase
AGREI_2674	COG1131	(ABC) transporter
AGREI_2677	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_2677	COG0204	Acyl-transferase
AGREI_2678	COG0514	ATP-dependent DNA helicase (RecQ)
AGREI_2685	COG0513	Belongs to the DEAD box helicase family
AGREI_2686	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AGREI_2688	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AGREI_2690	COG0423	glycine-tRNA ligase activity
AGREI_2692	COG0531	amino acid
AGREI_2695	COG2890	protein-(glutamine-N5) methyltransferase activity
AGREI_2700	COG0151	Belongs to the GarS family
AGREI_2701	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AGREI_2704	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AGREI_2706	COG2850	peptidyl-arginine hydroxylation
AGREI_2711	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_2712	COG1120	ATPase activity
AGREI_2714	COG2514	catechol 2,3-dioxygenase activity
AGREI_2715	COG0318	PFAM AMP-dependent synthetase and ligase
AGREI_2716	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AGREI_2717	COG0047	phosphoribosylformylglycinamidine synthase activity
AGREI_2718	COG0822	iron-sulfur transferase activity
AGREI_2720	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AGREI_2725	COG0287	Prephenate dehydrogenase
AGREI_2725	COG1605	Chorismate mutase
AGREI_2727	COG1764	response to oxidative stress
AGREI_2729	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AGREI_2736	COG0326	Molecular chaperone. Has ATPase activity
AGREI_2738	COG5002	protein histidine kinase activity
AGREI_2743	COG0745	RESPONSE REGULATOR receiver
AGREI_2745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AGREI_2752	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AGREI_2765	COG2814	Major facilitator Superfamily
AGREI_2766	COG2814	Major facilitator Superfamily
AGREI_2769	COG0546	phosphoglycolate phosphatase activity
AGREI_2775	COG0542	response to heat
AGREI_2776	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AGREI_2787	COG2813	Specifically methylates the guanine in position
AGREI_2788	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AGREI_2790	COG1335	isochorismatase
AGREI_2793	COG0789	Transcriptional regulator
AGREI_2794	COG0484	heat shock protein binding
AGREI_2795	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AGREI_2796	COG0443	Heat shock 70 kDa protein
AGREI_2803	COG1233	COG1233 Phytoene dehydrogenase and related
AGREI_2805	COG0142	geranyltranstransferase activity
AGREI_2806	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AGREI_2807	COG2111	Na H antiporter
AGREI_2807	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AGREI_2808	COG1006	Multisubunit Na H antiporter MnhC subunit
AGREI_2809	COG0651	ATP synthesis coupled electron transport
AGREI_2811	COG2212	antiporter activity
AGREI_2812	COG1320	monovalent cation:proton antiporter activity
AGREI_2813	COG0717	Belongs to the dCTP deaminase family
AGREI_2814	COG2261	transglycosylase associated protein
AGREI_2815	COG2197	response regulator
AGREI_2816	COG3527	Alpha-acetolactate decarboxylase
AGREI_2822	COG0395	ABC-type sugar transport system, permease component
AGREI_2832	COG2271	Major facilitator Superfamily
AGREI_2835	COG4565	transcriptional regulatory protein
AGREI_2836	COG3290	protein histidine kinase activity
AGREI_2837	COG1301	dicarboxylic acid transport
AGREI_2838	COG4608	Belongs to the ABC transporter superfamily
AGREI_2839	COG0444	Belongs to the ABC transporter superfamily
AGREI_2840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AGREI_2841	COG0601	transmembrane transport
AGREI_2842	COG0747	negative chemotaxis
AGREI_2846	COG0006	proline dipeptidase activity
AGREI_2849	COG1012	belongs to the aldehyde dehydrogenase family
AGREI_2850	COG1362	aminopeptidase activity
AGREI_2852	COG2267	carboxylic ester hydrolase activity
AGREI_2853	COG0531	amino acid
AGREI_2857	COG1846	Transcriptional regulator
AGREI_2862	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AGREI_2862	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AGREI_2862	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AGREI_2863	COG1105	Belongs to the carbohydrate kinase PfkB family
AGREI_2864	COG1349	DNA-binding transcription factor activity
AGREI_2865	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AGREI_2866	COG0671	phosphoesterase, PA-phosphatase related
AGREI_2867	COG0386	Belongs to the glutathione peroxidase family
AGREI_2870	COG1309	transcriptional regulator
AGREI_2873	COG0667	Aldo Keto reductase
AGREI_2876	COG1073	alpha beta
AGREI_2876	COG2226	methyltransferase
AGREI_2882	COG0419	ATPase involved in DNA repair
AGREI_2883	COG0420	3'-5' exonuclease activity
AGREI_2885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AGREI_2886	COG0686	Belongs to the AlaDH PNT family
AGREI_2893	COG2217	Heavy metal translocating P-type atpase
AGREI_2897	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AGREI_2900	COG2233	PERMEase
AGREI_2903	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AGREI_2903	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AGREI_2904	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AGREI_2906	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AGREI_2907	COG1120	ATPase activity
AGREI_2908	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_2916	COG1063	alcohol dehydrogenase
AGREI_2918	COG2367	Beta-lactamase
AGREI_2920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AGREI_2922	COG1349	DNA-binding transcription factor activity
AGREI_2925	COG1175	transmembrane transport
AGREI_2926	COG0395	ABC-type sugar transport system, permease component
AGREI_2930	COG1309	transcriptional regulator
AGREI_2931	COG2076	Multidrug Resistance protein
AGREI_2933	COG1929	Belongs to the glycerate kinase type-1 family
AGREI_2934	COG2814	Major facilitator Superfamily
AGREI_2935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AGREI_2946	COG3142	Participates in the control of copper homeostasis
AGREI_2948	COG0765	amino acid transport
AGREI_2949	COG0765	amino acid transport
AGREI_2951	COG1126	abc transporter atp-binding protein
AGREI_2952	COG1940	carbohydrate kinase activity
AGREI_2954	COG2084	Dehydrogenase
AGREI_2956	COG1172	Belongs to the binding-protein-dependent transport system permease family
AGREI_2958	COG1879	ABC-type sugar transport system periplasmic component
AGREI_2960	COG1609	Transcriptional regulator
AGREI_2962	COG3265	gluconokinase activity
AGREI_2963	COG1234	tRNA 3'-trailer cleavage
AGREI_2964	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AGREI_2966	COG4149	molybdate abc transporter
AGREI_2968	COG1609	Transcriptional regulator
AGREI_2971	COG2851	Citrate transporter
AGREI_2972	COG3290	protein histidine kinase activity
AGREI_2973	COG4565	transcriptional regulatory protein
AGREI_2983	COG0657	acetylesterase activity
AGREI_3002	COG1309	transcriptional regulator
AGREI_3003	COG4221	oxidoreductase activity
AGREI_3016	COG2072	flavoprotein involved in K transport
AGREI_3018	COG0657	acetylesterase activity
AGREI_3023	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AGREI_3030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_3031	COG0805	protein transport
AGREI_3032	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AGREI_3033	COG4251	negative regulation of phosphorylation
AGREI_3048	COG1349	DNA-binding transcription factor activity
AGREI_3051	COG1192	Involved in chromosome partitioning
AGREI_3053	COG3046	protein related to deoxyribodipyrimidine photolyase
AGREI_3074	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_3078	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AGREI_3078	COG2755	lipolytic protein G-D-S-L family
AGREI_3081	COG2197	response regulator
AGREI_3084	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AGREI_3096	COG0166	Belongs to the GPI family
AGREI_3097	COG0659	secondary active sulfate transmembrane transporter activity
AGREI_3100	COG0765	amino acid transport
AGREI_3101	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AGREI_3106	COG1228	amidohydrolase
AGREI_3107	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AGREI_3108	COG0180	Tryptophanyl-tRNA synthetase
AGREI_3112	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AGREI_3113	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AGREI_3114	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AGREI_3122	COG0673	inositol 2-dehydrogenase activity
AGREI_3129	COG1072	(Pantothenic acid kinase))
AGREI_3136	COG5398	heme oxygenase
AGREI_3138	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AGREI_3139	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AGREI_3141	COG1104	cysteine desulfurase activity
AGREI_3142	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AGREI_3144	COG3336	cytochrome c oxidase
AGREI_3145	COG0776	regulation of translation
AGREI_3146	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AGREI_3147	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AGREI_3148	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AGREI_3157	COG2267	carboxylic ester hydrolase activity
AGREI_3176	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AGREI_3179	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AGREI_3181	COG1476	TRANSCRIPTIONal
AGREI_3183	COG2197	response regulator
AGREI_3184	COG4585	Histidine kinase
AGREI_3186	COG1131	(ABC) transporter
AGREI_3191	COG2205	protein histidine kinase activity
AGREI_3192	COG0745	RESPONSE REGULATOR receiver
AGREI_3197	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AGREI_3199	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AGREI_3199	COG0351	phosphomethylpyrimidine kinase
AGREI_3199	COG0352	thiamine-phosphate diphosphorylase activity
AGREI_3206	COG1609	Transcriptional regulator
AGREI_3214	COG2197	response regulator
AGREI_3215	COG4585	Histidine kinase
AGREI_3224	COG0508	dehydrogenase complex catalyzes the overall conversion of
AGREI_3225	COG0022	dehydrogenase e1 component
AGREI_3227	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AGREI_3238	COG1357	PFAM Pentapeptide repeats (8 copies)
AGREI_3245	COG1609	Transcriptional regulator
AGREI_3249	COG1131	(ABC) transporter
AGREI_3251	COG0667	Aldo Keto reductase
AGREI_3262	COG0656	L-ascorbic acid biosynthetic process
AGREI_3268	COG1309	transcriptional regulator
AGREI_3272	COG1215	transferase activity, transferring glycosyl groups
AGREI_3277	COG1609	Transcriptional regulator
AGREI_3278	COG0395	ABC-type sugar transport system, permease component
AGREI_3279	COG1175	transmembrane transport
AGREI_3281	COG4948	Mandelate Racemase Muconate Lactonizing
AGREI_3285	COG0800	Aldolase
AGREI_3286	COG3458	cephalosporin-C deacetylase activity
AGREI_3290	COG0673	inositol 2-dehydrogenase activity
AGREI_3294	COG0673	inositol 2-dehydrogenase activity
AGREI_3296	COG0402	S-adenosylhomocysteine deaminase activity
AGREI_3297	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AGREI_3298	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AGREI_3299	COG3639	organic phosphonate transmembrane transporter activity
AGREI_3304	COG0587	DNA-directed DNA polymerase activity
AGREI_3315	COG0587	DNA-directed DNA polymerase activity
AGREI_3321	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AGREI_3322	COG3454	Phosphonate metabolism
AGREI_3323	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AGREI_3324	COG4778	phosphonate C-P lyase system protein PhnL
AGREI_3325	COG4107	phosphonate C-P lyase system protein PhnK
AGREI_3326	COG3627	carbon phosphorus lyase activity
AGREI_3327	COG3626	phosphonate metabolism
AGREI_3329	COG3624	Phosphonate C-P lyase system protein PhnG
AGREI_3330	COG2186	Transcriptional regulator
AGREI_3337	COG0135	phosphoribosylanthranilate isomerase activity
AGREI_3338	COG2375	cellular response to nickel ion
AGREI_3338	COG1132	(ABC) transporter
AGREI_3339	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AGREI_3340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_3341	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AGREI_3342	COG2197	response regulator
AGREI_3343	COG3850	Histidine kinase
AGREI_3345	COG0577	efflux transmembrane transporter activity
AGREI_3345	COG1136	(ABC) transporter
AGREI_3348	COG1028	Short-chain dehydrogenase reductase Sdr
AGREI_3353	COG1309	transcriptional regulator
AGREI_3354	COG0701	Predicted permease
AGREI_3358	COG0701	Predicted permease
AGREI_3364	COG3507	Belongs to the glycosyl hydrolase 43 family
AGREI_3370	COG1609	Transcriptional regulator
AGREI_3374	COG1819	glycosyl
AGREI_3376	COG1950	PFAM Membrane protein of
AGREI_3377	COG0697	spore germination
AGREI_3380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AGREI_3381	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AGREI_3389	COG1674	ftsk spoiiie
AGREI_3393	COG0631	protein serine/threonine phosphatase activity
AGREI_3397	COG0714	Associated with various cellular activities
AGREI_3406	COG0667	Aldo Keto reductase
AGREI_3408	COG0305	Participates in initiation and elongation during chromosome replication
AGREI_3409	COG0359	binds to the 23S rRNA
AGREI_3410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AGREI_3412	COG0360	Binds together with S18 to 16S ribosomal RNA
AGREI_3414	COG1120	ATPase activity
AGREI_3417	COG4139	cobalamin transport
AGREI_3418	COG0617	tRNA 3'-terminal CCA addition
AGREI_3421	COG0492	ferredoxin-NADP+ reductase activity
AGREI_3422	COG3118	belongs to the thioredoxin family
AGREI_3423	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AGREI_3429	COG1192	Involved in chromosome partitioning
AGREI_3431	COG0357	Ribosomal RNA small subunit methyltransferase G
AGREI_3433	COG0706	membrane insertase activity
AGREI_3434	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AGREI_3435	COG0594	ribonuclease P activity
AGREI_3436	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AGREI_P0001	COG0589	response to stress
AGREI_P0002	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AGREI_P0006	COG0587	DNA-directed DNA polymerase activity
AGREI_P0055	COG0542	response to heat
AGREI_P0076	COG0446	pyridine nucleotide-disulphide oxidoreductase
AGREI_P0078	COG0129	dihydroxy-acid dehydratase activity
AGREI_P0080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AGREI_P0081	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AGREI_P0082	COG0148	phosphopyruvate hydratase activity