locus-tag class description At12D13_00010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) At12D13_00020 ENOG4105CSA Coproporphyrinogen iii oxidase At12D13_00030 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) At12D13_00040 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) At12D13_00050 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) At12D13_00060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ At12D13_00070 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN At12D13_00080 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea At12D13_00090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) At12D13_00100 ENOG4108IUZ ABC transporter At12D13_00110 ENOG4105RF0 OstA family At12D13_00130 ENOG4105D07 Signal peptide peptidase, SppA At12D13_00140 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) At12D13_00170 ENOG4108RWN rrna methyltransferase At12D13_00180 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) At12D13_00190 ENOG4105BZU Histidine kinase At12D13_00210 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) At12D13_00220 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) At12D13_00230 ENOG4105CJR Integral membrane protein (MviN At12D13_00250 ENOG4105C31 Tryptophanyl-tRNA synthetase At12D13_00270 ENOG41083MR nifu domain-containing protein At12D13_00280 ENOG41072GX Peptidase M22 Glycoprotease At12D13_00290 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) At12D13_00300 ENOG41090R7 Ferric uptake At12D13_00310 ENOG4108Z20 Acyl-transferase At12D13_00320 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) At12D13_00330 ENOG4105C9A Phoh family At12D13_00340 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) At12D13_00360 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) At12D13_00370 ENOG4108WRK Transcriptional regulator At12D13_00380 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP At12D13_00390 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) At12D13_00400 ENOG4108RVA ribokinase At12D13_00410 ENOG4105CGY Dna recombination protein At12D13_00420 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) At12D13_00430 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) At12D13_00440 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) At12D13_00460 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) At12D13_00470 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) At12D13_00510 ENOG4108ZNX Heat shock protein At12D13_00560 ENOG4105CAS nag kinase At12D13_00580 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) At12D13_00590 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins At12D13_00600 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) At12D13_00610 ENOG4105C8Q Methyl-accepting chemotaxis At12D13_00660 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) At12D13_00730 ENOG4105DVF Cytosine-specific methyltransferase At12D13_00750 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) At12D13_00760 ENOG4108IJ9 (ABC) transporter At12D13_00770 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component At12D13_00780 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component At12D13_00810 ENOG4105CYC Transferase At12D13_00830 ENOG4105CTU Proline racemase At12D13_00840 ENOG4105EKE dihydroorotase At12D13_00850 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) At12D13_00890 ENOG4107QP8 phosphohexose isomerase At12D13_00900 ENOG4105CEY Amp-dependent synthetase and ligase At12D13_00910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_00920 ENOG4107QKW extracellular solute-binding protein family 1 At12D13_00930 ENOG4107Z6A sulfate abc transporter permease At12D13_00950 ENOG4105E0K tonB-dependent siderophore receptor At12D13_01010 ENOG4108C33 Resolvase At12D13_01070 ENOG4105CSR polyphosphate kinase 2 At12D13_01080 ENOG4105BZU Histidine kinase At12D13_01090 ENOG4105PWN phosphate abc transporter At12D13_01100 ENOG4105C8U phosphate abc transporter At12D13_01120 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) At12D13_01130 ENOG4108UTW Plays a role in the regulation of phosphate uptake At12D13_01140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family At12D13_01160 ENOG4105C8Y Acetylornithine aminotransferase At12D13_01170 ENOG4105DBV ornithine carbamoyltransferase At12D13_01180 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) At12D13_01190 ENOG4105NWN ApaG protein At12D13_01210 ENOG4105DHP deoxycytidine triphosphate deaminase At12D13_01260 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) At12D13_01360 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) At12D13_01390 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) At12D13_01430 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family At12D13_01440 ENOG4107QRT dEAD DEAH box helicase At12D13_01480 ENOG4108VCT Sulfite exporter TauE/SafE At12D13_01500 ENOG4105CSU acyl-Coa dehydrogenase At12D13_01510 ENOG4105CHU acetyl-coa acetyltransferase At12D13_01520 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase At12D13_01550 ENOG4105KJM monovalent cation h antiporter subunit g At12D13_01560 ENOG4105W4C monovalent cation H antiporter subunit F At12D13_01570 ENOG4105SC1 monovalent cation H antiporter subunit E At12D13_01580 ENOG4107R4Z monovalent cation h antiporter subunit d At12D13_01590 ENOG4108ZE9 Monovalent cation H antiporter subunit C At12D13_01600 ENOG4105D65 subunit l At12D13_01620 ENOG4105UT3 Methyl-accepting chemotaxis At12D13_01640 ENOG4108VYJ response regulator receiver protein At12D13_01650 ENOG4105CBS Chea signal transduction histidine kinase At12D13_01660 ENOG4105BZU Histidine kinase At12D13_01670 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) At12D13_01680 ENOG4108VYJ response regulator receiver protein At12D13_01690 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) At12D13_01710 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) At12D13_01720 ENOG4105VJY transcriptional regulator At12D13_01750 ENOG4105BZU Histidine kinase At12D13_01760 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) At12D13_01770 ENOG4105CHM Aminotransferase At12D13_01800 ENOG4105VYE Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) At12D13_01810 ENOG4108Z03 MAF-like protein At12D13_01820 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) At12D13_01840 ENOG4108ZTZ UPF0262 protein At12D13_01850 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) At12D13_01870 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) At12D13_01890 ENOG4107W75 Flagellin At12D13_01920 ENOG4105CN7 Flagellar biosynthetic protein FliP At12D13_01940 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) At12D13_01960 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) At12D13_01970 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA At12D13_01980 ENOG4105CGA flagellar basal-body rod protein FlgG At12D13_01990 ENOG4105X50 flagellar hook-basal body complex protein fliE At12D13_02000 ENOG4108ZC9 flagellar basal-body rod protein flgc At12D13_02010 ENOG4105SFI flagellar basal-body rod protein At12D13_02030 ENOG4108JIR Flagellum-specific ATP synthase At12D13_02040 ENOG4105KTQ flagellar basal-body rod protein At12D13_02060 ENOG4107RD7 Flagellar Motor Protein, MotA At12D13_02080 ENOG4105DD5 Flagellar motor switch protein At12D13_02090 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) At12D13_02100 ENOG4105D00 flagellar biosynthetic protein flhB At12D13_02110 ENOG4105QDQ At12D13_02140 ENOG4105ER2 Ompa motb domain protein At12D13_02150 ENOG4108S15 chemotaxis, protein At12D13_02190 ENOG4105BZE flagellar hook protein, FlgE At12D13_02230 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) At12D13_02240 ENOG410822I Flagellar hook capping protein At12D13_02250 ENOG4105VS8 Flagellar biosynthetic protein fliq At12D13_02260 ENOG4105D7B Flagellar biosynthesis protein flha At12D13_02270 ENOG4105D19 Role in flagellar biosynthesis (By similarity) At12D13_02340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) At12D13_02350 ENOG4105FKQ transcriptional regulator At12D13_02360 ENOG4105EPJ extracellular solute-binding protein family 1 At12D13_02370 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component At12D13_02380 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component At12D13_02390 ENOG4105CG3 alpha amylase, catalytic region At12D13_02400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_02420 ENOG4105X54 addiction module antidote protein At12D13_02440 ENOG4105C01 Dihydroxy-acid dehydratase At12D13_02450 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) At12D13_02460 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase At12D13_02470 ENOG4105CJP fad dependent oxidoreductase At12D13_02490 ENOG4105CBX hi0933 family At12D13_02560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_02570 ENOG4105F38 ABC transporter, permease At12D13_02580 ENOG4105D38 putrescine abc transporter At12D13_02600 ENOG4105BZU Histidine kinase At12D13_02610 ENOG4105C9X ppx gppa phosphatase At12D13_02620 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) At12D13_02630 ENOG4105C0R drug resistance transporter emrb qaca subfamily At12D13_02720 ENOG4108RIR Molybdenum cofactor biosynthesis protein At12D13_02730 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) At12D13_02750 ENOG4105EAH synthase At12D13_02800 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit At12D13_02820 ENOG4108V0P LemA family At12D13_02830 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase At12D13_02850 ENOG4105C38 Glycyl-tRNA synthetase beta subunit At12D13_02860 ENOG4105EWC Purine nucleoside phosphorylase At12D13_02890 ENOG4105C12 Phosphoribosylglycinamide synthetase At12D13_02900 ENOG4105BZM domain protein At12D13_02910 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase At12D13_03000 ENOG4105CJ3 phosphate transporter At12D13_03020 ENOG4108E2B had-superfamily hydrolase, subfamily iib At12D13_03030 ENOG4107STW synthase At12D13_03040 ENOG4105C6F GntR Family Transcriptional Regulator At12D13_03060 ENOG410642W LysR family Transcriptional regulator At12D13_03070 ENOG4105CQB FAD linked oxidase domain protein At12D13_03080 ENOG4105CQB FAD linked oxidase domain protein At12D13_03090 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) At12D13_03110 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein At12D13_03120 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) At12D13_03140 ENOG4105HMI Membrane At12D13_03150 ENOG4108M0I Transcriptional regulator At12D13_03190 ENOG4105CUT histidyl-tRNA synthetase At12D13_03200 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit At12D13_03210 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) At12D13_03220 ENOG4108SB3 DoxX Family At12D13_03240 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) At12D13_03250 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) At12D13_03270 ENOG4105DTN riboflavin biosynthesis protein ribF At12D13_03280 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) At12D13_03300 ENOG4108Z6B deaminase At12D13_03310 ENOG4105FE9 pseudouridine synthase At12D13_03320 ENOG4106H78 methyltransferase At12D13_03330 ENOG4105D78 K07001 NTE family protein At12D13_03340 ENOG4105CKD glutathione-regulated potassium-efflux system protein At12D13_03350 ENOG4105CMS peptidase U62, modulator of DNA gyrase At12D13_03360 ENOG4107TK4 histidinol-phosphate phosphatase At12D13_03380 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase At12D13_03400 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) At12D13_03420 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) At12D13_03430 ENOG4105BZU Histidine kinase At12D13_03440 ENOG4105BZU Histidine kinase At12D13_03450 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein At12D13_03460 ENOG4108RTU Aldolase At12D13_03470 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 At12D13_03480 ENOG4105FGE Short-chain dehydrogenase reductase Sdr At12D13_03500 ENOG4107WYG Transcriptional regulator, luxr family At12D13_03510 ENOG4105I5W Transporter At12D13_03520 ENOG4105D1F ATP-binding protein At12D13_03530 ENOG4107QUT magnesium and cobalt transport protein CorA At12D13_03540 ENOG4105DFH Transport of potassium into the cell (By similarity) At12D13_03560 ENOG4107PQ6 Inherit from NOG: atp synthase At12D13_03570 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) At12D13_03580 ENOG4105VD1 ATP synthase subunit C At12D13_03590 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) At12D13_03620 ENOG4105EQK -acetyltransferase At12D13_03630 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) At12D13_03670 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) At12D13_03690 ENOG4105DVW rieske (2Fe-2S) At12D13_03720 ENOG4105W6J BA14K family At12D13_03740 ENOG4105CSU acyl-Coa dehydrogenase At12D13_03770 ENOG4107QS4 23S rRNA At12D13_03780 ENOG4105DX0 Hemolysin A At12D13_03810 ENOG4108XM1 transcriptional regulator AsnC family At12D13_03870 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) At12D13_03880 ENOG4105EUB pirin domain protein At12D13_03890 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) At12D13_03910 ENOG4107ZYJ bioY protein At12D13_03920 ENOG4107QCX Transporter At12D13_03930 ENOG4108JJB ABC transporter At12D13_03940 ENOG4105T0Z Conserved Protein At12D13_03950 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) At12D13_03960 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase At12D13_03980 ENOG4105CVJ phosphoglycerate mutase At12D13_03990 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH At12D13_04020 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) At12D13_04050 ENOG4107YBY Hydrolase At12D13_04070 ENOG4105D1U peptidase U62 modulator of DNA gyrase At12D13_04090 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) At12D13_04100 ENOG4105BZ9 Cytochrome C oxidase, subunit I At12D13_04110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) At12D13_04130 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) At12D13_04140 ENOG4107QS1 Cytochrome C Oxidase, Subunit III At12D13_04160 ENOG4108R6F Surfeit locus 1 family protein At12D13_04170 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) At12D13_04180 ENOG4105CUV Homoserine Kinase At12D13_04190 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) At12D13_04220 ENOG4105EHV domain protein At12D13_04240 ENOG4108UJU UPF0301 protein At12D13_04280 ENOG4105D9U N-acetyltransferase At12D13_04290 ENOG4105C1V Peptidase, M16 At12D13_04300 ENOG4105D98 threonine synthase At12D13_04320 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 At12D13_04330 ENOG4108PVQ transcriptional regulator At12D13_04360 ENOG4105CEC DNA methylase N-4 N-6 At12D13_04370 ENOG4105YAJ CopG Arc MetJ At12D13_04400 ENOG4105CEN a g-specific adenine glycosylase At12D13_04420 ENOG4108R9S DSBA oxidoreductase At12D13_04430 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) At12D13_04450 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase At12D13_04460 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) At12D13_04490 ENOG4108ETY sodium dicarboxylate symporter At12D13_04540 ENOG4105DWT malate dehydrogenase (quinone) At12D13_04560 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) At12D13_04570 ENOG4105C11 sulfate adenylyltransferase), subunit 2 At12D13_04580 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) At12D13_04590 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family At12D13_04600 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein At12D13_04610 ENOG4108I5D sulfate abc transporter At12D13_04630 ENOG4108IJ6 ABC transporter At12D13_04650 ENOG4108NJZ Sensory box GGDEF EAL domain protein At12D13_04670 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) At12D13_04680 ENOG4105C26 Dehydrogenase At12D13_04690 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) At12D13_04780 ENOG4105C0R drug resistance transporter emrb qaca subfamily At12D13_04800 ENOG4107T0X DNA ligase At12D13_04820 ENOG4108ST3 glycosyltransferase At12D13_04840 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein At12D13_04850 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein At12D13_04860 ENOG4105K56 Transcriptional regulator At12D13_04870 ENOG4108ZHJ Organic hydroperoxide resistance protein At12D13_04900 ENOG4105C5H ABC transporter At12D13_04960 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_04970 ENOG4105EMU Dehydrogenase At12D13_05000 ENOG4105D7A ATP-binding protein At12D13_05020 ENOG4105KVH Transcriptional regulator At12D13_05030 ENOG4108VHC Short-chain dehydrogenase reductase Sdr At12D13_05060 ENOG4105CV8 reductase At12D13_05070 ENOG4105FFC UPF0187 protein At12D13_05080 ENOG4105D29 Helix-turn-helix type 11 domain protein At12D13_05100 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) At12D13_05110 ENOG4105CM2 brancheD-chain amino acid aminotransferase At12D13_05120 ENOG4105C8Q Methyl-accepting chemotaxis At12D13_05160 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) At12D13_05180 ENOG4105D29 Helix-turn-helix type 11 domain protein At12D13_05190 ENOG4108NIW Leucine export protein LeuE At12D13_05200 ENOG4105TAV cytochrome C At12D13_05210 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding At12D13_05320 ENOG4108IJ7 Glycine betaine At12D13_05330 ENOG4108HQS Glycine betaine At12D13_05370 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_05390 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) At12D13_05410 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase At12D13_05440 ENOG4108UT2 hemolysin iii At12D13_05460 ENOG4105E0X reductase At12D13_05470 ENOG4105D65 subunit l At12D13_05480 ENOG4105HC0 Na H antiporter At12D13_05490 ENOG4108ZE9 Monovalent cation H antiporter subunit C At12D13_05500 ENOG4108JPZ Monovalent cation H antiporter subunit D At12D13_05510 ENOG4105SC1 monovalent cation H antiporter subunit E At12D13_05520 ENOG41080TA Multiple resistance and ph regulation protein f At12D13_05530 ENOG4105KJM monovalent cation h antiporter subunit g At12D13_05540 ENOG4108YXV Transcriptional regulator At12D13_05570 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) At12D13_05580 ENOG4105WZR At12D13_05590 ENOG4105BZU Histidine kinase At12D13_05710 ENOG4108JQC penicillin-binding protein 1A At12D13_05720 ENOG4108ZZ3 UPF0260 protein At12D13_05790 ENOG4105MZG transcriptional modulator of maze toxin, mazf At12D13_05840 ENOG4105CNG UPF0061 protein At12D13_05860 ENOG4105EW9 transcriptional regulator AsnC family At12D13_06120 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_06130 ENOG4105CUX Signal transduction histidine kinase At12D13_06150 ENOG4106FI7 cytochrome c-type biogenesis protein At12D13_06160 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) At12D13_06170 ENOG4105DA4 cytochrome c-type biogenesis protein At12D13_06180 ENOG4105KWW Biogenesis protein At12D13_06190 ENOG4105C0H protease At12D13_06220 ENOG4105Z4Q MltA-interacting MipA family protein At12D13_06230 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) At12D13_06240 ENOG4105BZU Histidine kinase At12D13_06260 ENOG4105CD8 aminopeptidase N At12D13_06270 ENOG4108EHX EamA-like transporter family At12D13_06300 ENOG4105R8A Heat shock protein At12D13_06310 ENOG4105BZU Histidine kinase At12D13_06320 ENOG4105CHR reductase At12D13_06360 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase At12D13_06380 ENOG4105CIS alcohol dehydrogenase At12D13_06390 ENOG4105KVH Transcriptional regulator At12D13_06400 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) At12D13_06410 ENOG4105CJW magnesium transporter At12D13_06420 ENOG4105F27 Major Facilitator At12D13_06440 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) At12D13_06480 ENOG4105FYV Amp nucleosidase At12D13_06540 ENOG4105CIH Imidazole acetol-phosphate transaminase At12D13_06630 ENOG4107SC1 transglycosylase At12D13_06640 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_06650 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) At12D13_06680 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) At12D13_06720 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) At12D13_06730 ENOG4105C3F Signal peptidase i At12D13_06740 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) At12D13_06750 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) At12D13_06760 ENOG4105DS0 Transcriptional regulator, Crp Fnr family At12D13_06770 ENOG41074H6 response regulator At12D13_06780 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) At12D13_06800 ENOG4105DMQ Methyltransferase At12D13_06820 ENOG4105EST Metal Dependent Phosphohydrolase At12D13_06840 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase At12D13_06870 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component At12D13_06880 ENOG4108MEK Metal-binding protein YodA At12D13_06890 ENOG4105D64 Mechanosensitive ion channel At12D13_06910 ENOG4108R7K Metal Dependent Phosphohydrolase At12D13_06960 ENOG4108Z4K mutator MutT protein At12D13_06970 ENOG4105KK4 UPF0060 membrane protein At12D13_06990 ENOG4105BZU Histidine kinase At12D13_07010 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase At12D13_07020 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme At12D13_07030 ENOG4108JJ7 ABC transporter At12D13_07040 ENOG4108WZM domain protein At12D13_07050 ENOG4108URH decarboxylase At12D13_07070 ENOG4105FR1 rard protein At12D13_07110 ENOG4105WDY DNA (cytosine-5-)-methyltransferase At12D13_07120 ENOG4105C8N cysteinyl-tRNA synthetase At12D13_07130 ENOG4105PDP Short chain dehydrogenase At12D13_07140 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase At12D13_07150 ENOG4105E96 Colicin v production protein At12D13_07190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) At12D13_07200 ENOG4105E7U AraC family transcriptional regulator At12D13_07210 ENOG4108UMN azlc family At12D13_07230 ENOG4108JJ7 ABC transporter At12D13_07240 ENOG4105CDU Replicative dna helicase At12D13_07280 ENOG4105K9Q Binds to the 23S rRNA (By similarity) At12D13_07300 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) At12D13_07310 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) At12D13_07320 ENOG4105CPC Aldo Keto reductase At12D13_07330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase At12D13_07350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) At12D13_07360 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) At12D13_07370 ENOG4105HHA aminodeoxychorismate lyase At12D13_07380 ENOG4105DSJ YicC domain protein At12D13_07390 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) At12D13_07410 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) At12D13_07420 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) At12D13_07440 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) At12D13_07470 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) At12D13_07490 ENOG4105BZU Histidine kinase At12D13_07510 ENOG4105BZU Histidine kinase At12D13_07520 ENOG4105BZU Histidine kinase At12D13_07550 ENOG4105C5H ABC transporter At12D13_07560 ENOG4105BZU Histidine kinase At12D13_07580 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) At12D13_07620 ENOG4108ZAF Molybdopterin At12D13_07630 ENOG4105M00 molybdopterin converting factor, subunit 1 At12D13_07650 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) At12D13_07660 ENOG4105H9W Short-chain dehydrogenase reductase Sdr At12D13_07670 ENOG4105JVC membrAne At12D13_07680 ENOG4108U78 Glutathione S-transferase At12D13_07710 ENOG4105D6S protein involved in catabolism of external DNA At12D13_07720 ENOG4107QY8 reductase At12D13_07750 ENOG4108V3E phosphoribosylglycinamide formyltransferase At12D13_07760 ENOG4105CXB phosphoribosylaminoimidazole synthetase At12D13_07770 ENOG4105C02 permease At12D13_07790 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) At12D13_07800 ENOG4105C9X ppx gppa phosphatase At12D13_07850 ENOG4108Q35 Adenylate At12D13_07870 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) At12D13_07880 ENOG4108ISG Major Facilitator At12D13_07890 ENOG4105C9M aspartyl-trna synthetase At12D13_07910 ENOG4105CT7 inner membrane cred family protein At12D13_07920 ENOG4105CHH sulfate transporter At12D13_07940 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) At12D13_07950 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate At12D13_07970 ENOG4105D52 delta-aminolevulinic acid dehydratase At12D13_08010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) At12D13_08020 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) At12D13_08030 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) At12D13_08060 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) At12D13_08070 ENOG4107XZX Involved in the transcription termination process (By similarity) At12D13_08080 ENOG4105DXI Major Facilitator superfamily At12D13_08090 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for At12D13_08130 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) At12D13_08140 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) At12D13_08150 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) At12D13_08160 ENOG4105WJX transcriptional regulator MERR family At12D13_08210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_08220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_08230 ENOG4105C3U ABC transporter At12D13_08270 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) At12D13_08280 ENOG4105C7B Threonine dehydratase At12D13_08300 ENOG4105BZU Histidine kinase At12D13_08310 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) At12D13_08320 ENOG4107653 Transcriptional regulator At12D13_08330 ENOG4105CGH 5'-nucleotidase At12D13_08380 ENOG4105KHC sulfurtransferase At12D13_08410 ENOG4105CVP deoxyribo-dipyrimidine photolyase At12D13_08430 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) At12D13_08630 ENOG4108TPP exopolysaccharide synthesis At12D13_08730 ENOG4105D3Q Sugar transferase At12D13_08740 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase At12D13_08790 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) At12D13_08810 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase At12D13_08820 ENOG4105CYW agmatinase At12D13_08830 ENOG4108UJD 30S ribosomal protein S9 At12D13_08840 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) At12D13_08860 ENOG4105K4P CoA-binding domain protein At12D13_08910 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr At12D13_08920 ENOG4106A3M Cytochrome p-450 At12D13_08930 ENOG4105BZU Histidine kinase At12D13_08940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) At12D13_08950 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) At12D13_08960 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) At12D13_09000 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain At12D13_09010 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) At12D13_09020 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain At12D13_09040 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) At12D13_09060 ENOG4105GKE subunit e At12D13_09070 ENOG4107QIZ NADH dehydrogenase At12D13_09080 ENOG4107R0R NADH dehydrogenase subunit g At12D13_09090 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) At12D13_09100 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) At12D13_09110 ENOG4105DF2 NADH dehydrogenase subunit j At12D13_09120 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) At12D13_09130 ENOG4105D65 subunit l At12D13_09140 ENOG4105C8S subunit m At12D13_09150 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) At12D13_09190 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) At12D13_09210 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) At12D13_09220 ENOG4105C0B DNA polymerase III (alpha subunit) At12D13_09240 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) At12D13_09260 ENOG4108UXN response regulator At12D13_09270 ENOG4105BZU Histidine kinase At12D13_09280 ENOG4105W0E 50S ribosomal protein L33 At12D13_09290 ENOG4108ISG Major Facilitator At12D13_09320 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) At12D13_09330 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) At12D13_09350 ENOG4105C79 DNA protecting protein DprA At12D13_09360 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) At12D13_09370 ENOG4105CD3 dihydroorotase At12D13_09380 ENOG4105CXT aspartate transcarbamylase At12D13_09400 ENOG4105CSU acyl-Coa dehydrogenase At12D13_09410 ENOG4108ZBR Gcn5-related n-acetyltransferase At12D13_09470 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) At12D13_09480 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA At12D13_09490 ENOG4107T8T UPF0173 metal-dependent hydrolase At12D13_09500 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) At12D13_09510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) At12D13_09520 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) At12D13_09530 ENOG4105YCT UPF0386 protein At12D13_09560 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) At12D13_09580 ENOG410849A acetyltransferase, (GNAT) family At12D13_09610 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) At12D13_09620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase At12D13_09630 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein At12D13_09640 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) At12D13_09650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) At12D13_09700 ENOG4105CHR reductase At12D13_09710 ENOG4105C03 ribonuclease At12D13_09720 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase At12D13_09740 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) At12D13_09770 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) At12D13_09780 ENOG4105JAB phenazine biosynthesis protein, phzf family At12D13_09810 ENOG4107Z7P Ferredoxin At12D13_09830 ENOG4105EEI dihydropteroate synthase At12D13_09840 ENOG4105KRF dihydroneopterin aldolase At12D13_09850 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase At12D13_09870 ENOG4106K28 UPF0283 membrane protein At12D13_09880 ENOG4105CM6 amino acid regulated cytosolic protein At12D13_09900 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters At12D13_09940 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) At12D13_10000 ENOG4105K59 histidine triad (HIT) protein At12D13_10050 ENOG4105CE9 30S ribosomal protein S2 At12D13_10060 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) At12D13_10070 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) At12D13_10080 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) At12D13_10090 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) At12D13_10100 ENOG4105KNE Phosphatidate cytidylyltransferase At12D13_10110 ENOG4105DZP Membrane-associated zinc metalloprotease At12D13_10120 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane At12D13_10130 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) At12D13_10140 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) At12D13_10150 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) At12D13_10160 ENOG4105GYT Protein of unknown function (DUF1009) At12D13_10170 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) At12D13_10180 ENOG41073TP transcriptional regulator At12D13_10200 ENOG4105E5Q amino acid AbC transporter At12D13_10210 ENOG4105E5Q amino acid AbC transporter At12D13_10230 ENOG4105BZN citrate synthase At12D13_10260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) At12D13_10270 ENOG4108JEH abc transporter atp-binding protein At12D13_10280 ENOG4105E5Q amino acid AbC transporter At12D13_10290 ENOG4105DRP amino acid AbC transporter At12D13_10300 ENOG4106PMH Extracellular solute-binding protein family 3 At12D13_10310 ENOG4108JQ1 Dehydrogenase At12D13_10320 ENOG4108IJ9 (ABC) transporter At12D13_10330 ENOG4105DRS transport system, permease At12D13_10350 ENOG4107FKK extracellular solute-binding protein family 1 At12D13_10370 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_10380 ENOG4105CHR reductase At12D13_10390 ENOG4105CPQ Dehydrogenase At12D13_10400 ENOG4108Z2U ureidoglycolate hydrolase At12D13_10410 ENOG4108IV0 ABC, transporter At12D13_10420 ENOG4105C0Z ABC transporter At12D13_10440 ENOG4105CP9 extracellular ligand-binding receptor At12D13_10450 ENOG4105CSU acyl-Coa dehydrogenase At12D13_10480 ENOG4105E9F Enoyl-CoA hydratase At12D13_10510 ENOG4105CNQ glycine cleavage T protein, aminomethyl transferase At12D13_10550 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase At12D13_10560 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) At12D13_10580 ENOG4108JYK Dehydrogenase At12D13_10590 ENOG4105CPP Dehydrogenase, E1 component At12D13_10610 ENOG4105C7S Dehydrogenase At12D13_10630 ENOG4107QN2 dihydrolipoyl dehydrogenase At12D13_10650 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) At12D13_10660 ENOG4105DXC membrane At12D13_10700 ENOG4108Z1B Cyclase dehydrase At12D13_10710 ENOG4107TH8 cina domain protein At12D13_10720 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) At12D13_10740 ENOG4105CUX Signal transduction histidine kinase At12D13_10750 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family At12D13_10760 ENOG4105ES5 Histidine kinase At12D13_10770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family At12D13_10780 ENOG4105C1A potassium transporter peripheral membrane At12D13_10790 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) At12D13_10800 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) At12D13_10810 ENOG4105DXN mazG family At12D13_10830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) At12D13_10860 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) At12D13_10870 ENOG4105DP0 ferredoxin-NADP reductase At12D13_10910 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor At12D13_10920 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) At12D13_10930 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) At12D13_10980 ENOG41082CG Protein CrcB homolog At12D13_10990 ENOG4105EI2 Pseudouridine synthase At12D13_11000 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) At12D13_11030 ENOG4108UQ8 endoribonuclease L-psp At12D13_11040 ENOG4105C4W S-formylglutathione hydrolase At12D13_11060 ENOG4108UPT UPF0178 protein At12D13_11080 ENOG4105D3R alkyl hydroperoxide reductase At12D13_11170 ENOG4105CAU Arsenical resistance protein, ArsH At12D13_11180 ENOG4105D6J arsenicaL-resistance protein At12D13_11220 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) At12D13_11230 ENOG4105F8V Hydrolase, tatD family At12D13_11240 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) At12D13_11250 ENOG4107QRG dna polymerase iii At12D13_11260 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) At12D13_11270 ENOG4105DZ1 carboxypeptidase At12D13_11360 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) At12D13_11370 ENOG41081FY multiple antibiotic resistance (MarC)-related At12D13_11380 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) At12D13_11400 ENOG4105YAJ CopG Arc MetJ At12D13_11410 ENOG4108UUM single-stranded DNA-binding protein At12D13_11420 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) At12D13_11440 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) At12D13_11450 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase At12D13_11460 ENOG4108Z0R Transferase At12D13_11480 ENOG4105FAV ABC, transporter At12D13_11490 ENOG4105FDK ABC transporter At12D13_11500 ENOG4105NXV High-affinity zinc uptake system protein At12D13_11510 ENOG4105ETE Transcriptional regulator (LacI family At12D13_11530 ENOG4105CPC Aldo Keto reductase At12D13_11550 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) At12D13_11690 ENOG4105D8X mechanosensitive ion channel At12D13_11740 ENOG4105CJW magnesium transporter At12D13_11750 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit At12D13_11770 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) At12D13_11820 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) At12D13_11830 ENOG4105DQ4 alcohol dehydrogenase At12D13_11920 ENOG4105E2A Dehydrogenase At12D13_11930 ENOG4105U5Y Transcriptional regulator At12D13_11940 ENOG41068W2 Cytochrome p-450 At12D13_11960 ENOG4105D7W serine acetyltransferase At12D13_11990 ENOG4105MSY salicylate hydroxylase At12D13_12000 ENOG4105C28 cystathionine At12D13_12010 ENOG4107QXX ABC transporter At12D13_12020 ENOG4105EZ7 amino acid ABC transporter At12D13_12030 ENOG4105DRP amino acid AbC transporter At12D13_12040 ENOG4105CDA abc transporter atp-binding protein At12D13_12050 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) At12D13_12070 ENOG4105D6E homoserine dehydrogenase At12D13_12080 ENOG4105CHM Aminotransferase At12D13_12140 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) At12D13_12160 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) At12D13_12170 ENOG4105J3Q acyl carrier protein At12D13_12180 ENOG4105D4P Coproporphyrinogen iii oxidase At12D13_12190 ENOG4105DS0 Transcriptional regulator, Crp Fnr family At12D13_12210 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class At12D13_12220 ENOG4105PW4 Sugar fermentation stimulation protein homolog At12D13_12230 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) At12D13_12240 ENOG4105W5Q DNA repair protein (RadC At12D13_12270 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase At12D13_12280 ENOG4105DC8 reductase At12D13_12300 ENOG4105E66 phosphoriboisomerase A At12D13_12310 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) At12D13_12330 ENOG4105C9Q fumarate hydratase class II At12D13_12350 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) At12D13_12360 ENOG4107EJC Preprotein translocase subunit SecG At12D13_12370 ENOG4105CP7 Triose-phosphate isomerase At12D13_12390 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) At12D13_12410 ENOG4108JGH Tetr family transcriptional regulator At12D13_12420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) At12D13_12430 ENOG4108535 NAD dependent epimerase/dehydratase family At12D13_12440 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) At12D13_12460 ENOG4105KBH arsR family transcriptional regulator At12D13_12470 ENOG4107RZC phospholipase d At12D13_12480 ENOG4108VYJ response regulator receiver protein At12D13_12500 ENOG4105EGS Mechanosensitive ion channel At12D13_12620 ENOG4105DHJ ABC, transporter At12D13_12630 ENOG4105CY3 ABC transporter, permease At12D13_12640 ENOG4107S8C mandelate racemase muconate lactonizing At12D13_12670 ENOG4105C6K Malic enzyme At12D13_12690 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase At12D13_12700 ENOG4108MR6 WD40-like Beta Propeller Repeat At12D13_12710 ENOG4105C4K Nad synthetase At12D13_12720 ENOG4107T7U Sulfatase At12D13_12770 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation At12D13_12800 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) At12D13_12810 ENOG4107QPD alcohol dehydrogenase At12D13_12840 ENOG4105CEY Amp-dependent synthetase and ligase At12D13_12870 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) At12D13_12880 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) At12D13_12890 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) At12D13_12900 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) At12D13_12910 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) At12D13_12950 ENOG4108I0Q anthranilate phosphoribosyltransferase At12D13_12960 ENOG4105DK0 Indole-3-glycerol phosphate synthase At12D13_12970 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) At12D13_12980 ENOG4105CVM Molybdenum cofactor synthesis domain protein At12D13_12990 ENOG4105BZU Histidine kinase At12D13_13010 ENOG4105CKD glutathione-regulated potassium-efflux system protein At12D13_13030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) At12D13_13050 ENOG4105CZQ inner membrane transport protein YdhC At12D13_13060 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) At12D13_13070 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b At12D13_13080 ENOG4105DR5 peptidase At12D13_13090 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) At12D13_13100 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) At12D13_13110 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) At12D13_13120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) At12D13_13140 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) At12D13_13150 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) At12D13_13160 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) At12D13_13170 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) At12D13_13190 ENOG4105C75 arginyL-tRNA synthetase At12D13_13200 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein At12D13_13210 ENOG4108YX9 iron--sulfur cluster insertion protein erpA At12D13_13230 ENOG4108P7N Exopolysaccharide production negative regulator At12D13_13250 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) At12D13_13270 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) At12D13_13350 ENOG4105CS1 NAD(P)H quinone oxidoreductase At12D13_13360 ENOG4107TH8 cina domain protein At12D13_13380 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) At12D13_13390 ENOG4107RTZ reductase At12D13_13420 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) At12D13_13440 ENOG4105BZ1 (ABC) transporter At12D13_13450 ENOG4105IPI Membrane At12D13_13490 ENOG4107XWI flavin reductase domain protein, FMN-binding At12D13_13520 ENOG4105C22 threonyL-tRNA synthetase At12D13_13540 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) At12D13_13560 ENOG4105EUJ GTP cyclohydrolase i At12D13_13570 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase At12D13_13580 ENOG4105D78 K07001 NTE family protein At12D13_13590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) At12D13_13650 ENOG4105EJQ L-serine dehydratase At12D13_13740 ENOG4105ECQ AraC Family Transcriptional Regulator At12D13_13750 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) At12D13_13770 ENOG4105C5F glutamine synthetase At12D13_13790 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) At12D13_13830 ENOG4108JHT EamA-like transporter family At12D13_13870 ENOG4105CB5 ATP-dependent DNA helicase recG At12D13_13930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) At12D13_13940 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) At12D13_13950 ENOG4107EJG GntR family transcriptional regulator At12D13_13980 ENOG4105UIB (ABC) transporter At12D13_13990 ENOG4105C2J ABC transporter At12D13_14000 ENOG4105VE1 Phosphatidylcholine synthase At12D13_14010 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) At12D13_14020 ENOG4105RK9 auxin efflux carrier At12D13_14030 ENOG4107QIV Cytochrome c biogenesis protein At12D13_14090 ENOG4105VEQ Cold shock protein At12D13_14170 ENOG4105D74 hydrolase At12D13_14200 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) At12D13_14210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) At12D13_14230 ENOG4105QAS Iron-sulfur cluster assembly accessory protein At12D13_14240 ENOG4105VG1 fes assembly suf system protein At12D13_14260 ENOG4105JRK feS assembly protein SufD At12D13_14300 ENOG4105C3J Cysteine desulfurase At12D13_14310 ENOG4105DHZ alpha beta At12D13_14320 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) At12D13_14330 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) At12D13_14350 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen At12D13_14360 ENOG4105ED9 Protein of unknown function (DUF455) At12D13_14370 ENOG4105DR5 peptidase At12D13_14380 ENOG4105C1J atp-dependent rna helicase At12D13_14420 ENOG4105DJV ribulose-phosphate 3-epimerase At12D13_14440 ENOG4105C83 adenylosuccinate lyase At12D13_14460 ENOG4107QPR SAICAR synthetase At12D13_14470 ENOG4105VR9 phosphoribosylformylglycinamidine synthase At12D13_14480 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I At12D13_14510 ENOG4107SQD Transcriptional regulator, GntR family At12D13_14530 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii At12D13_14580 ENOG4105C2C drug resistance transporter, Bcr CflA At12D13_14590 ENOG4105ECY inositol monophosphatase At12D13_14600 ENOG4108MWI inositol mono-phosphatase At12D13_14610 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) At12D13_14620 ENOG4105CSV Glutaminase At12D13_14630 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) At12D13_14640 ENOG4105DU1 integral membrane protein, terc At12D13_14660 ENOG4108594 Permease of the drug metabolite transporter At12D13_14670 ENOG410829K Lysine exporter protein (Lyse ygga) At12D13_14700 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) At12D13_14710 ENOG4105CVS RNA methyltransferase TrmH family, group 1 At12D13_14780 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) At12D13_14790 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) At12D13_14800 ENOG4107UH8 sugar kinase At12D13_14810 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) At12D13_14830 ENOG4106TNF Periplasmic binding protein At12D13_14840 ENOG4105GBT ABC transporter At12D13_14860 ENOG4105P0T Usg family At12D13_14880 ENOG4105GVF (ABC) transporter At12D13_14890 ENOG4108XM1 transcriptional regulator AsnC family At12D13_14900 ENOG4108RG0 uracil-dna glycosylase At12D13_14920 ENOG4105BZU Histidine kinase At12D13_14940 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) At12D13_14950 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) At12D13_14980 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) At12D13_14990 ENOG4108R85 Short chain dehydrogenase At12D13_15010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator At12D13_15020 ENOG4105CNN ABC, transporter At12D13_15030 ENOG4108HHA Transketolase At12D13_15040 ENOG4108IUS Transketolase At12D13_15050 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) At12D13_15060 ENOG4107RHR regulatoR At12D13_15080 ENOG4105E3A (ABC) transporter At12D13_15090 ENOG4105DA5 (ABC) transporter At12D13_15100 ENOG4105HF0 Membrane At12D13_15120 ENOG41080BE Methyl-accepting chemotaxis sensory transducer At12D13_15120 ENOG41080BE Methyl-accepting chemotaxis sensory transducer At12D13_15140 ENOG4105D1H recombination factor protein RarA At12D13_15150 ENOG4105C0H protease At12D13_15180 ENOG4105C01 Dihydroxy-acid dehydratase At12D13_15190 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) At12D13_15200 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) At12D13_15220 ENOG4105NX3 Membrane At12D13_15230 ENOG4108ZT0 50S ribosomal protein l17 At12D13_15240 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) At12D13_15250 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) At12D13_15260 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits At12D13_15270 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) At12D13_15280 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) At12D13_15290 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) At12D13_15300 ENOG41084HQ 50S ribosomal protein L30 At12D13_15310 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) At12D13_15320 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) At12D13_15330 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) At12D13_15340 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) At12D13_15350 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) At12D13_15360 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits At12D13_15370 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) At12D13_15380 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) At12D13_15390 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal At12D13_15400 ENOG41083MP 50s ribosomal protein l29 At12D13_15410 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) At12D13_15420 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) At12D13_15430 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) At12D13_15440 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) At12D13_15450 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity At12D13_15460 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) At12D13_15470 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) At12D13_15480 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) At12D13_15490 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) At12D13_15500 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) At12D13_15510 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) At12D13_15520 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) At12D13_15530 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) At12D13_15570 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) At12D13_15580 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) At12D13_15590 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) At12D13_15600 ENOG4108VZM 50s ribosomal protein L10 At12D13_15610 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) At12D13_15620 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) At12D13_15650 ENOG4105C5E polysaccharide biosynthesis protein At12D13_15660 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) At12D13_15670 ENOG4108ZCF integral membrane protein At12D13_15690 ENOG410642K Lysozyme inhibitor At12D13_15730 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase At12D13_15750 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase At12D13_15770 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase At12D13_15800 ENOG4105K6V RNA polymerase At12D13_15830 ENOG4107QQR Sporulation At12D13_15840 ENOG4105BZU Histidine kinase At12D13_15850 ENOG41074H6 response regulator At12D13_15860 ENOG4105BZU Histidine kinase At12D13_15880 ENOG4105BZU Histidine kinase At12D13_15890 ENOG4105C2N RNA methyltransferase TrmH family group 3 At12D13_15900 ENOG4105NAU thioesterase Superfamily protein At12D13_15950 ENOG4108RYK Nad-dependent epimerase dehydratase At12D13_15960 ENOG4105KVH Transcriptional regulator At12D13_15970 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) At12D13_16020 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) At12D13_16040 ENOG4105BZU Histidine kinase At12D13_16060 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_16080 ENOG4107QKW extracellular solute-binding protein family 1 At12D13_16090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family At12D13_16100 ENOG4105NWF RbsD or FucU transport At12D13_16110 ENOG4105KRQ Addiction module toxin, Txe YoeB family At12D13_16130 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase At12D13_16150 ENOG4105CF7 AraC family transcriptional regulator At12D13_16160 ENOG4105DQ4 alcohol dehydrogenase At12D13_16170 ENOG4105CEP NADH dehydrogenase At12D13_16180 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) At12D13_16190 ENOG4105VJY transcriptional regulator At12D13_16200 ENOG4107SID ATP-dependent exodnase (exonuclease v) At12D13_16260 ENOG4105CV8 reductase At12D13_16290 ENOG4108ZP8 Acetolactate synthase small subunit At12D13_16300 ENOG4105C7K acetolactate synthase At12D13_16320 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) At12D13_16330 ENOG4105EAC phosphoserine phosphatase At12D13_16340 ENOG4108YYQ gCN5-related N-acetyltransferase At12D13_16380 ENOG4105EPW hflc protein At12D13_16390 ENOG4107QJR hflk protein At12D13_16400 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) At12D13_16410 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) At12D13_16470 ENOG4105CQB FAD linked oxidase domain protein At12D13_16480 ENOG4105BZS acriflavin resistance protein At12D13_16490 ENOG4105ENT Efflux transporter rnd family, mfp subunit At12D13_16590 ENOG4108RWI nicotinamidase At12D13_16630 ENOG4105DC7 peptidase M24 At12D13_16660 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) At12D13_16670 ENOG4108ZX6 Electron transport protein SCO1 SenC At12D13_16680 ENOG4108V3W Chemotaxis protein, CheW At12D13_16700 ENOG4105UMD exodeoxyribonuclease X At12D13_16710 ENOG4105ETT transcriptional Regulator, LysR family At12D13_16730 ENOG4105WCN acetyltransferase At12D13_16750 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) At12D13_16760 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) At12D13_16770 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane At12D13_16780 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) At12D13_16790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) At12D13_16800 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) At12D13_16810 ENOG4108UFP Essential cell division protein (By similarity) At12D13_16820 ENOG4105CPF Cell wall formation (By similarity) At12D13_16830 ENOG4105CSH Transporter At12D13_16840 ENOG4105BZU Histidine kinase At12D13_16850 ENOG4105D4A Cell wall formation (By similarity) At12D13_16860 ENOG4105DFU Cell wall formation (By similarity) At12D13_16870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) At12D13_16890 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) At12D13_16900 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) At12D13_16920 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) At12D13_16950 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) At12D13_16960 ENOG4107YUR Cell division protein mraZ At12D13_16970 ENOG4105Z6B inner membrane protein yjfl At12D13_16990 ENOG4106032 Glutathionylspermidine synthase At12D13_17030 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase At12D13_17040 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) At12D13_17090 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) At12D13_17120 ENOG4105SYT Methylenetetrahydrofolate reductase At12D13_17150 ENOG4105E5G Alpha beta hydrolase fold At12D13_17160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F At12D13_17190 ENOG4105M4H endoribonuclease L-psp At12D13_17220 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein At12D13_17230 ENOG4105EQ0 Major Facilitator superfamily At12D13_17280 ENOG4105C26 Dehydrogenase At12D13_17310 ENOG4105C5F glutamine synthetase At12D13_17320 ENOG4105CUB amino acid At12D13_17340 ENOG4105QEK Transcriptional regulator At12D13_17380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_17430 ENOG4105C3R Methionine synthase At12D13_17440 ENOG4107QKS N-acylglucosamine 2-epimerase At12D13_17680 ENOG4105MPN Membrane At12D13_17710 ENOG4105BZU Histidine kinase At12D13_17730 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) At12D13_17740 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) At12D13_17760 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain At12D13_17770 ENOG4107QI1 Mate efflux family protein At12D13_17780 ENOG4105C8Q Methyl-accepting chemotaxis At12D13_17800 ENOG4105CGZ zinc metallopeptidase At12D13_17830 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain At12D13_17850 ENOG4105BZU Histidine kinase At12D13_17880 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) At12D13_17900 ENOG4105F7P transcriptional regulator AsnC family At12D13_17910 ENOG4105C3M thioredoxin reductase At12D13_17920 ENOG4105CBN LysR family transcriptional regulator At12D13_17940 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase At12D13_18000 ENOG4105CHM Aminotransferase At12D13_18010 ENOG4108KMM Diguanylate cyclase At12D13_18050 ENOG4105C5X domain protein At12D13_18070 ENOG41090HR transcriptional regulator At12D13_18080 ENOG4105DPZ Two component transcriptional regulator (Winged helix family At12D13_18090 ENOG4105E0F Histidine kinase At12D13_18100 ENOG4108Z7R Chaperone CsaA At12D13_18110 ENOG4105II7 pyrroline-5-carboxylate reductase At12D13_18140 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) At12D13_18160 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase At12D13_18190 ENOG4105C5T Phosphoribosyl pyrophosphate synthase At12D13_18210 ENOG4107G9V glycosyl transferase, family 39 At12D13_18230 ENOG4105CKK Glycosyl transferase, family 2 At12D13_18250 ENOG4105C26 Dehydrogenase At12D13_18260 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) At12D13_18270 ENOG4105BZU Histidine kinase At12D13_18290 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) At12D13_18320 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) At12D13_18340 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) At12D13_18350 ENOG4105C3G gtp-binding protein At12D13_18380 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) At12D13_18400 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) At12D13_18420 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) At12D13_18440 ENOG4105BZ1 (ABC) transporter At12D13_18450 ENOG4105BZ1 (ABC) transporter At12D13_18460 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) At12D13_18470 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) At12D13_18480 ENOG4105EAM Na Pi-cotransporter At12D13_18500 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) At12D13_18530 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate At12D13_18540 ENOG4105M6F mutator MutT protein At12D13_18560 ENOG4105C7R Atpase associated with various cellular activities aaa_3 At12D13_18600 ENOG4105VEV -acetyltransferase At12D13_18610 ENOG41079KZ Major Facilitator Superfamily At12D13_18630 ENOG4105CHF Glutathione S-transferase At12D13_18660 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) At12D13_18670 ENOG4105DKK Benzoate At12D13_18700 ENOG4105NCT RNA Polymerase At12D13_18720 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) At12D13_18750 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) At12D13_18800 ENOG41080HT Transcriptional regulator, arsr family At12D13_18810 ENOG4108IJ7 Glycine betaine At12D13_18840 ENOG4107104 thymidine kinase At12D13_18880 ENOG4108TEB UPF0114 protein At12D13_18910 ENOG4105CRQ synthase (Component I) At12D13_18930 ENOG4105CPI Metal Dependent Phosphohydrolase At12D13_18940 ENOG4105CPN adenine deaminase At12D13_18970 ENOG4105CG3 alpha amylase, catalytic region At12D13_18980 ENOG4107SS6 2-dehydro-3-deoxygluconokinase At12D13_19020 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) At12D13_19080 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) At12D13_19120 ENOG4105C7W Xanthine dehydrogenase At12D13_19150 ENOG4105ETT transcriptional Regulator, LysR family At12D13_19180 ENOG4107QUY Guanine deaminase At12D13_19210 ENOG4105DMF Dehydrogenase At12D13_19230 ENOG4108RZE Tetr family transcriptional regulator At12D13_19240 ENOG4105DZ1 carboxypeptidase At12D13_19270 ENOG4108Z2U ureidoglycolate hydrolase At12D13_19320 ENOG4108TXN phosphonate metabolism protein At12D13_19330 ENOG41087SS fad dependent oxidoreductase At12D13_19340 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) At12D13_19350 ENOG4105BZU Histidine kinase At12D13_19360 ENOG4105C1J atp-dependent rna helicase At12D13_19370 ENOG4107RT3 EamA-like transporter family At12D13_19380 ENOG4105MGM doxx family At12D13_19390 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein At12D13_19440 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) At12D13_19460 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase At12D13_19490 ENOG4108HWW ABC transporter At12D13_19500 ENOG4105C2J ABC transporter At12D13_19510 ENOG4105DFW ABC transporter At12D13_19600 ENOG4105C6X Major Facilitator At12D13_19630 ENOG4105DSP amino acid AbC transporter At12D13_19640 ENOG4106TNF Periplasmic binding protein At12D13_19650 ENOG4108JEH abc transporter atp-binding protein At12D13_19760 ENOG4108Z18 K06886 hemoglobin At12D13_19800 ENOG4108R86 Transcriptional regulator At12D13_19810 ENOG4105CE7 Amidase, hydantoinase carbamoylase family At12D13_19820 ENOG4105CD3 dihydroorotase At12D13_19830 ENOG4105M6F mutator MutT protein At12D13_19850 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component At12D13_19860 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component At12D13_19910 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) At12D13_19920 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) At12D13_19930 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) At12D13_19940 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) At12D13_19970 ENOG4105CQM Urea amidohydrolase subunit alpha At12D13_19980 ENOG4106ISJ urease accessory protein At12D13_19990 ENOG4105VTN Protein of unknown function (DUF1311) At12D13_20010 ENOG4105KI2 Urea amidohydrolase subunit beta At12D13_20020 ENOG4105XDF Protein of unknown function (DUF1272) At12D13_20030 ENOG4108YZ9 Urea amidohydrolase subunit gamma At12D13_20040 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) At12D13_20060 ENOG4108IV0 ABC, transporter At12D13_20070 ENOG4105C0Z ABC transporter At12D13_20090 ENOG4105C32 Amino acid ABC transporter (Permease) At12D13_20120 ENOG4107R5B glutamine synthetase At12D13_20130 ENOG4105CHR reductase At12D13_20140 ENOG4105BZU Histidine kinase At12D13_20150 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase At12D13_20200 ENOG4108IV0 ABC, transporter At12D13_20210 ENOG4105C0Z ABC transporter At12D13_20220 ENOG4105CF8 branched-chain amino acid ABC transporter, permease At12D13_20230 ENOG4105C32 Amino acid ABC transporter (Permease) At12D13_20240 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase At12D13_20300 ENOG4105EFQ Two component transcriptional regulator (Winged helix family At12D13_20430 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) At12D13_20450 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis At12D13_20500 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase At12D13_20520 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) At12D13_20530 ENOG4107XDR Lactoylglutathione lyase At12D13_20540 ENOG4105WD1 Membrane At12D13_20550 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) At12D13_20560 ENOG4105EHG Permease protein At12D13_20570 ENOG4107R4I Periplasmic binding protein At12D13_20590 ENOG41090JE Utilization Protein At12D13_20620 ENOG41062D9 Histidine kinase At12D13_20700 ENOG4105DHS permease protein At12D13_20710 ENOG4105CM4 permease protein At12D13_20720 ENOG4108IPW abc transporter atp-binding protein At12D13_20730 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction At12D13_20750 ENOG4105CC0 LysR family Transcriptional regulator At12D13_20770 ENOG4105ENT Efflux transporter rnd family, mfp subunit At12D13_20810 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) At12D13_20820 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) At12D13_20830 ENOG4107B2H carbonic anhydrase At12D13_20850 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) At12D13_20870 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) At12D13_20880 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) At12D13_20890 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) At12D13_20900 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) At12D13_20910 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) At12D13_20920 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) At12D13_20930 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) At12D13_20940 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) At12D13_20950 ENOG4108YNN Heme oxygenase At12D13_20960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_20980 ENOG4107VUR extracellular solute-binding protein At12D13_21000 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_21020 ENOG4108MGF sugar kinase At12D13_21040 ENOG4105F0I Aminotransferase At12D13_21050 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) At12D13_21070 ENOG4108JQ7 (ABC) transporter At12D13_21090 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_21100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_21110 ENOG4108J59 Extracellular solute-binding protein, family 5 At12D13_21120 ENOG4108IGT Dipeptidase At12D13_21140 ENOG4105FF5 Membrane At12D13_21180 ENOG4105D2S major facilitator superfamily At12D13_21220 ENOG4105KHM amidohydrolase 2 At12D13_21230 ENOG4108KC1 acyl-Coa dehydrogenase At12D13_21350 ENOG4105C8V SAICAR synthetase At12D13_21370 ENOG4105C1P efflux transporter, rnd family, mfp subunit At12D13_21380 ENOG4105BZS acriflavin resistance protein At12D13_21400 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) At12D13_21410 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) At12D13_21420 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein At12D13_21450 ENOG4105CBN LysR family transcriptional regulator At12D13_21460 ENOG4105CJP fad dependent oxidoreductase At12D13_21470 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein At12D13_21480 ENOG4105E0C molybdate abc transporter At12D13_21490 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) At12D13_21510 ENOG4105KXX peptidase s58 dmpa At12D13_21520 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) At12D13_21550 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) At12D13_21560 ENOG410609C Acyl carrier protein At12D13_21620 ENOG4105BZ1 (ABC) transporter At12D13_21630 ENOG4105IJJ transcriptional regulator, crp fnr family At12D13_21670 ENOG4107QQG Dehydrogenase At12D13_21680 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) At12D13_21720 ENOG4107QSI ABC, transporter At12D13_21730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_21740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_21760 ENOG4107TYR Glycosyl Transferase At12D13_21770 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) At12D13_21780 ENOG4106N3A copper homeostasis protein cutc At12D13_21810 ENOG4105E2D ec 3.2.1.52 At12D13_21820 ENOG4108KEZ Dehydrogenase At12D13_21830 ENOG4106KNT transcriptional regulator At12D13_21850 ENOG4108IJ9 (ABC) transporter At12D13_21870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_21900 ENOG4105FDP GntR family transcriptional regulator At12D13_21920 ENOG4105CE4 GlcNAc 6-P deacetylase At12D13_21930 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) At12D13_21950 ENOG4105YVM Phosphoesterase, PA-phosphatase related At12D13_21960 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) At12D13_21970 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) At12D13_21990 ENOG4105CFU surface antigen At12D13_22010 ENOG4108V3W Chemotaxis protein, CheW At12D13_22020 ENOG4107SDU Methyl-accepting chemotaxis At12D13_22030 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) At12D13_22040 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) At12D13_22050 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) At12D13_22060 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) At12D13_22070 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) At12D13_22080 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) At12D13_22100 ENOG4105C25 Primosomal protein n' At12D13_22110 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) At12D13_22150 ENOG4107QN2 dihydrolipoyl dehydrogenase At12D13_22160 ENOG4105N14 lysine exporter protein LysE YggA At12D13_22180 ENOG4105C7S Dehydrogenase At12D13_22200 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha At12D13_22210 ENOG4105CMV Succinyl-CoA synthetase subunit beta At12D13_22220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) At12D13_22230 ENOG4105D6Z AFG1 family ATPase At12D13_22240 ENOG4105YU5 Outer membrane lipoprotein At12D13_22250 ENOG4105E33 succinate dehydrogenase At12D13_22260 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) At12D13_22280 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) At12D13_22300 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) At12D13_22330 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase At12D13_22340 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) At12D13_22350 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) At12D13_22400 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) At12D13_22430 ENOG410856B UPF0235 protein At12D13_22440 ENOG4105F0N pyrophosphate phospho-hydrolase At12D13_22480 ENOG4105DGW oligopeptidase A At12D13_22490 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) At12D13_22500 ENOG4105C0R drug resistance transporter emrb qaca subfamily At12D13_22510 ENOG4105CDH Citrulline--aspartate ligase At12D13_22530 ENOG410829K Lysine exporter protein (Lyse ygga) At12D13_22540 ENOG4107T0D ABC, transporter At12D13_22550 ENOG4105C7J ABC transporter, permease At12D13_22570 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs At12D13_22600 ENOG4105KZX Pterin carbinolamine dehydratase At12D13_22610 ENOG4105KJF protein tyrosine phosphatase At12D13_22620 ENOG4105M7V 2'-5' rna ligase At12D13_22640 ENOG4108I0Y (ABC) transporter At12D13_22660 ENOG4105HFZ Membrane At12D13_22690 ENOG4107QM5 aconitate hydratase At12D13_22700 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) At12D13_22710 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) At12D13_22720 ENOG41060IM Heme exporter protein At12D13_22750 ENOG4106TD9 Diguanylate cyclase At12D13_22760 ENOG4108VRQ UPF0314 protein At12D13_22770 ENOG4107835 probably involved in intracellular septation (By similarity) At12D13_22780 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) At12D13_22790 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) At12D13_22800 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) At12D13_22820 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY At12D13_22830 ENOG4105EHE chorismate mutase- prephenate dehydrogenase At12D13_22840 ENOG4105K5M 30s ribosomal protein S16 At12D13_22850 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) At12D13_22860 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) At12D13_22880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) At12D13_22930 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) At12D13_22940 ENOG4105ERG peptidase m48, ste24p At12D13_22950 ENOG4107T0D ABC, transporter At12D13_22990 ENOG4105C5H ABC transporter At12D13_23010 ENOG4105CVG Homoserine O-transsuccinylase At12D13_23020 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) At12D13_23030 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase At12D13_23040 ENOG4105CTB Polyprenyl synthetase At12D13_23050 ENOG4108ZG0 Ompa motb domain protein At12D13_23060 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) At12D13_23070 ENOG4106UW1 Major Facilitator superfamily At12D13_23080 ENOG4105MVE transcriptional regulator At12D13_23090 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) At12D13_23100 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_23110 ENOG4105BZ1 (ABC) transporter At12D13_23130 ENOG4105E2V Glycosyltransferase 36 At12D13_23140 ENOG4105CH2 amidohydrolase At12D13_23160 ENOG4105D5U fad dependent oxidoreductase At12D13_23180 ENOG4105C01 Dihydroxy-acid dehydratase At12D13_23190 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase At12D13_23200 ENOG4105EXW epimerase dehydratase At12D13_23210 ENOG4105CQB FAD linked oxidase domain protein At12D13_23220 ENOG4107YCY Transcriptional regulator At12D13_23240 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter At12D13_23250 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_23260 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit At12D13_23270 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) At12D13_23290 ENOG4105DFA alanine racemase domain protein At12D13_23300 ENOG4105C8T Leucyl-tRNA synthetase At12D13_23330 ENOG4108Z4U Ferredoxin At12D13_23370 ENOG4105C29 acyl-CoA thioesterase At12D13_23380 ENOG4108YZA Nitrogen regulatory protein pii At12D13_23390 ENOG4105BZU Histidine kinase At12D13_23400 ENOG4105CNU cell division protein FtsK At12D13_23410 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) At12D13_23440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family At12D13_23460 ENOG4108VJ1 Transcriptional regulator (CarD family At12D13_23470 ENOG4105C7I Dehydrogenase At12D13_23480 ENOG4105DEU major facilitator superfamily At12D13_23510 ENOG4105CHR reductase At12D13_23540 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) At12D13_23560 ENOG4105CN1 protease At12D13_23580 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) At12D13_23600 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) At12D13_23610 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) At12D13_23620 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) At12D13_23630 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control At12D13_23660 ENOG4105K46 50S ribosomal protein l27 At12D13_23670 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) At12D13_23720 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) At12D13_23730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) At12D13_23750 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) At12D13_23760 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) At12D13_23770 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) At12D13_23900 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) At12D13_23920 ENOG4105EFT decarboxylase At12D13_23930 ENOG4105DIA mandelate racemase muconate lactonizing At12D13_23940 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) At12D13_23950 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase At12D13_23960 ENOG4105CPQ Dehydrogenase At12D13_24000 ENOG4107RNG ABC transporter At12D13_24010 ENOG4105C2J ABC transporter At12D13_24020 ENOG4107YCY Transcriptional regulator At12D13_24030 ENOG4105CTX dehydratase At12D13_24040 ENOG4105DC1 bifunctional purine biosynthesis protein purh At12D13_24060 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B At12D13_24070 ENOG4105D0M Protease HtpX homolog At12D13_24090 ENOG4105FA0 parb-like partition protein At12D13_24100 ENOG4107QJE Chromosome Partitioning Protein At12D13_24110 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) At12D13_24120 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) At12D13_24130 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) At12D13_24140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) At12D13_24150 ENOG4108YXA Membrane At12D13_24160 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) At12D13_24170 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) At12D13_24180 ENOG4108UHJ MAF-like protein At12D13_24190 ENOG4105E2X shikimate dehydrogenase At12D13_24200 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) At12D13_24210 ENOG4108JDX DNA polymerase iii, epsilon subunit At12D13_24220 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) At12D13_24230 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 At12D13_24250 ENOG4105CA3 membrane-bound lytic murein transglycosylase At12D13_24280 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) At12D13_24300 ENOG4105ERH Fumarylacetoacetate hydrolase At12D13_24330 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase At12D13_24340 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) At12D13_24350 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) At12D13_24360 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) At12D13_24390 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation At12D13_24410 ENOG4108S0S Nucleotidyl transferase At12D13_24420 ENOG4105EHM Aminoglycoside phosphotransferase At12D13_24430 ENOG4105I8F Histidine kinase At12D13_24440 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) At12D13_24450 ENOG41080Z8 PHOSPHOCARRIER protein At12D13_24460 ENOG4108EQA pts system At12D13_24470 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) At12D13_24480 ENOG4105EB3 Histidine kinase At12D13_24490 ENOG4105E3W Two component transcriptional regulator (Winged helix family At12D13_24500 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase At12D13_24510 ENOG4108YZN class I peptide chain release factor At12D13_24520 ENOG4105CS9 pantothenic acid kinase At12D13_24530 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase At12D13_24540 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) At12D13_24550 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase At12D13_24560 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) At12D13_24580 ENOG4105ECC imidazole-glycerol-phosphate dehydratase At12D13_24590 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) At12D13_24600 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) At12D13_24620 ENOG4107QP3 malate synthase g At12D13_24650 ENOG4108UYB regulatoR At12D13_24660 ENOG4105TX3 Histidine kinase At12D13_24670 ENOG4105CQ7 ATP-dependent helicase At12D13_24710 ENOG4105C9U ATP-dependent DNA helicase RecQ At12D13_24730 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator At12D13_24740 ENOG4105CNN ABC, transporter At12D13_24750 ENOG4105C2J ABC transporter At12D13_24760 ENOG4105CS9 pantothenic acid kinase At12D13_24770 ENOG4105WAZ (Glutaredoxin-like protein) NrdH At12D13_24780 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) At12D13_24820 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) At12D13_24900 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) At12D13_24910 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) At12D13_24920 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) At12D13_24930 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) At12D13_24940 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) At12D13_24950 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) At12D13_24980 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) At12D13_24990 ENOG4107SFI Major Facilitator superfamily At12D13_25000 ENOG4105CVE Lytic murein transglycosylase At12D13_25010 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) At12D13_25030 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) At12D13_25040 ENOG4107QMP dna polymerase iii subunits gamma and tau At12D13_25060 ENOG4105E09 nadh pyrophosphatase At12D13_25070 ENOG4105CQC Prephenate dehydratase At12D13_25080 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) At12D13_25090 ENOG4105G9V cytochrome C At12D13_25120 ENOG4108JQC penicillin-binding protein 1A At12D13_25130 ENOG4108UIN ybak prolyl-trna synthetase associated region At12D13_25150 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) At12D13_25170 ENOG4105C2M dna polymerase I At12D13_25190 ENOG41082R8 50S ribosomal protein l32 At12D13_25200 ENOG4105CQZ Histidine kinase At12D13_25210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family At12D13_25250 ENOG41069P5 Protein slyX homolog At12D13_25270 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) At12D13_25280 ENOG4105CFG Acts as a chaperone (By similarity) At12D13_25300 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) At12D13_25310 ENOG4105DIH basic membrane At12D13_25320 ENOG4108JQ9 ABC transporter At12D13_25350 ENOG4105KG3 cytidine deaminase At12D13_25360 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) At12D13_25370 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) At12D13_25380 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) At12D13_25400 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) At12D13_25410 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) At12D13_25420 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) At12D13_25440 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) At12D13_25450 ENOG4105CCU oxidase (Subunit III) At12D13_25460 ENOG4105BZ9 Cytochrome C oxidase, subunit I At12D13_25470 ENOG4105E2S oxidase) subunit II At12D13_25480 ENOG4105CSH Transporter At12D13_25490 ENOG4105CBC glutamate synthase At12D13_25500 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) At12D13_25530 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH At12D13_25550 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) At12D13_25570 ENOG4105EN6 Membrane At12D13_25610 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component At12D13_25650 ENOG4108ZZF transport protein (ExbD) At12D13_25670 ENOG4105DG4 malate L-lactate dehydrogenase At12D13_25700 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) At12D13_25710 ENOG4105FD8 phosphonate metabolism protein PhnM At12D13_25720 ENOG4108TXN phosphonate metabolism protein At12D13_25740 ENOG4105S7S phosphonate abc transporter At12D13_25750 ENOG4105EHI Phosphonate ABC transporter, periplasmic At12D13_25760 ENOG4105D5T phosphonate abc transporter At12D13_25780 ENOG4105HRV phosphonate c-p lyase system protein phnl At12D13_25790 ENOG4105ENV phosphonate C-P lyase system protein PhnK At12D13_25860 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) At12D13_25870 ENOG4105CHC glucokinase (EC 2.7.1.2) At12D13_25880 ENOG4108Z5K methylglyoxal synthase At12D13_25890 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) At12D13_25910 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component At12D13_25920 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component At12D13_25930 ENOG4108JQ5 ABC transporter At12D13_25940 ENOG4105MWK D-amino acid dehydrogenase, small subunit At12D13_25950 ENOG4105CFQ glutamine synthetase At12D13_25960 ENOG4105CJP fad dependent oxidoreductase At12D13_25970 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family At12D13_25980 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component At12D13_25990 ENOG4108IJ8 ABC transporter At12D13_26000 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component At12D13_26010 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system At12D13_26030 ENOG4105KPV Transcriptional regulator At12D13_26070 ENOG4105C26 Dehydrogenase At12D13_26100 ENOG4105DFI Membrane At12D13_26130 ENOG4107SN7 NLP P60 protein At12D13_26150 ENOG4107RH7 Nicotinate phosphoribosyltransferase At12D13_26160 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) At12D13_26310 ENOG4105KWI UPF0339 protein At12D13_26320 ENOG4108UQ1 hydrolase, family 25 At12D13_26330 ENOG4105T38 integral membrane protein At12D13_26340 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family At12D13_26400 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) At12D13_26410 ENOG4105ES4 Nitrilase At12D13_26470 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) At12D13_26480 ENOG4105CH5 extracellular solute-binding protein, family 7 At12D13_26530 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) At12D13_26540 ENOG41082BR 50S ribosomal protein L35 At12D13_26550 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) At12D13_26570 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) At12D13_26580 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) At12D13_26590 ENOG4105CPC Aldo Keto reductase At12D13_26600 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_26620 ENOG4108FN7 Aldo keto reductase At12D13_26680 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) At12D13_26690 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_26710 ENOG4108ZT1 Transcriptional regulator At12D13_26720 ENOG4108KTG Membrane protein, drug metabolite transporter At12D13_26730 ENOG4105C88 aminopeptidase At12D13_26740 ENOG4108Z66 YbaK ebsC protein At12D13_26750 ENOG4105KUZ arsenate reductase At12D13_26780 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) At12D13_26800 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) At12D13_26830 ENOG4105KAV tspo and mbr like protein At12D13_26880 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B At12D13_26890 ENOG4105K6T rare lipoprotein A At12D13_26910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) At12D13_26930 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) At12D13_26970 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) At12D13_26990 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) At12D13_27000 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) At12D13_27010 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) At12D13_27020 ENOG41082FP UPF0102 protein At12D13_27070 ENOG4108IJ9 (ABC) transporter At12D13_27090 ENOG4105D7Z glutathione synthase At12D13_27100 ENOG4105C0P Mg chelatase subunit ChlI At12D13_27130 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) At12D13_27140 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) At12D13_27150 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase At12D13_27180 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) At12D13_27190 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) At12D13_27200 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) At12D13_27210 ENOG4105E39 Enoyl-CoA hydratase At12D13_27220 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) At12D13_27280 ENOG4105NPE arsR family transcriptional regulator At12D13_27380 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_27400 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component At12D13_27410 ENOG4105E0S extracellular solute-binding protein family 1 At12D13_27430 ENOG4105CHR reductase At12D13_27450 ENOG4105C5I Dehydrogenase At12D13_27470 ENOG4105EQX glucarate dehydratase At12D13_27500 ENOG4105E2R ROK family At12D13_27520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_27530 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_27570 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_27600 ENOG4105D44 asparaginase At12D13_27620 ENOG4105CJP fad dependent oxidoreductase At12D13_27630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_27660 ENOG4105MWK D-amino acid dehydrogenase, small subunit At12D13_27690 ENOG4108JQ6 ABC transporter At12D13_27720 ENOG4107QZ7 Cellulose synthase catalytic subunit At12D13_27740 ENOG4105EEQ Na H antiporter At12D13_27750 ENOG4105CQ0 ABC transporter At12D13_27760 ENOG4105BZU Histidine kinase At12D13_27770 ENOG4105ETE Transcriptional regulator (LacI family At12D13_27800 ENOG4105CNN ABC, transporter At12D13_27810 ENOG41080QX K07048 phosphotriesterase-related protein At12D13_27830 ENOG4105DE4 1-phosphofructokinase At12D13_27850 ENOG4105CE7 Amidase, hydantoinase carbamoylase family At12D13_27890 ENOG4105CYX Short-chain dehydrogenase reductase Sdr At12D13_27900 ENOG4108IND Tetr family transcriptional regulator At12D13_27910 ENOG4105C2W permease At12D13_27930 ENOG4105ETT transcriptional Regulator, LysR family At12D13_27990 ENOG4105EMN RNA polymerase sigma factor At12D13_28000 ENOG410633P Hydantoin racemase At12D13_28010 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component At12D13_28020 ENOG4105F38 ABC transporter, permease At12D13_28040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_28090 ENOG4107SDU Methyl-accepting chemotaxis At12D13_28130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component At12D13_28140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_28150 ENOG4105DRS transport system, permease At12D13_28220 ENOG4105ETE Transcriptional regulator (LacI family At12D13_28240 ENOG4105C5I Dehydrogenase At12D13_28250 ENOG4108WBH protein TIM barrel At12D13_28260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_28270 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component At12D13_28280 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component At12D13_28290 ENOG4105BZ7 extracellular solute-binding protein family 1 At12D13_28300 ENOG4108W9H Tetr family transcriptional regulator At12D13_28340 ENOG4105DDC Oxidoreductase domain protein At12D13_28390 ENOG4105K5G 30S ribosomal protein S21 At12D13_28440 ENOG4105FAT Acyl-transferase At12D13_28450 ENOG4107XII Glycosyl Hydrolase Family 88 At12D13_28480 ENOG4108IJ9 (ABC) transporter At12D13_28490 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component At12D13_28500 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component At12D13_28520 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_28540 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit At12D13_28550 ENOG4105GAK amidohydrolase 2 At12D13_28560 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_28570 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase At12D13_28580 ENOG4105CHR reductase At12D13_28590 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) At12D13_28600 ENOG4105E9Z Nad-dependent epimerase dehydratase At12D13_28610 ENOG4105JXH GntR family transcriptional regulator At12D13_28710 ENOG4105EU0 Major facilitator Superfamily At12D13_28730 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_28750 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit At12D13_28760 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase At12D13_28790 ENOG4105ETE Transcriptional regulator (LacI family At12D13_28800 ENOG4105CPQ Dehydrogenase At12D13_28810 ENOG4105CHR reductase At12D13_28830 ENOG4107UEK pfkb domain protein At12D13_28840 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of At12D13_28870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_28890 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_28900 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component At12D13_28920 ENOG4105C28 cystathionine At12D13_28940 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) At12D13_28950 ENOG4105DSE periplasmic solute binding protein At12D13_28960 ENOG4105CC5 ABC transporter At12D13_28970 ENOG4105DIK (ABC) transporter At12D13_28980 ENOG4105CKI cobalamin synthesis protein At12D13_29010 ENOG4105CKI cobalamin synthesis protein At12D13_29020 ENOG4108IJG ABC transporter substrate-binding protein At12D13_29030 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component At12D13_29040 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component At12D13_29050 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_29130 ENOG4105CC0 LysR family Transcriptional regulator At12D13_29140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator At12D13_29150 ENOG4105CNN ABC, transporter At12D13_29180 ENOG4105BZS acriflavin resistance protein At12D13_29190 ENOG4105C1P efflux transporter, rnd family, mfp subunit At12D13_29200 ENOG4105BZU Histidine kinase At12D13_29210 ENOG4105S0E allantoin catabolism protein At12D13_29240 ENOG4105DG4 malate L-lactate dehydrogenase At12D13_29260 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_29290 ENOG4108JQ6 ABC transporter At12D13_29330 ENOG4105C01 Dihydroxy-acid dehydratase At12D13_29340 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator At12D13_29350 ENOG4105C2J ABC transporter At12D13_29360 ENOG4107R9N ABC transporter At12D13_29370 ENOG41062B0 ABC transporter, permease At12D13_29380 ENOG4107EJG GntR family transcriptional regulator At12D13_29400 ENOG4105C0B DNA polymerase III (alpha subunit) At12D13_29410 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA At12D13_29490 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_29510 ENOG4105XN3 extracellular solute-binding protein family 1 At12D13_29530 ENOG4105EPC oxidoreductase At12D13_29560 ENOG4105BZU Histidine kinase At12D13_29570 ENOG4107RP9 extracellular solute-binding protein, family 3 At12D13_29590 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) At12D13_29600 ENOG4107QMS site-determining protein At12D13_29610 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) At12D13_29620 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 At12D13_29630 ENOG4107YCY Transcriptional regulator At12D13_29640 ENOG4108ERU trap dicarboxylate transporter subunit DctP At12D13_29660 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_29670 ENOG4105CPQ Dehydrogenase At12D13_29680 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) At12D13_29710 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit At12D13_29720 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_29730 ENOG4108JQ6 ABC transporter At12D13_29740 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) At12D13_29770 ENOG41069H0 dihydroorotase EC 3.5.2.3 At12D13_29800 ENOG4106R87 Extracellular solute-binding protein, family 5 At12D13_29810 ENOG4105JNK Glycosyl transferase (Group 1 At12D13_29890 ENOG4107QM2 Aldo Keto reductase At12D13_29920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_29930 ENOG4107T3P ABC, transporter At12D13_29940 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component At12D13_29950 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_29960 ENOG4105CJQ hydrolase, family 31 At12D13_29970 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component At12D13_29980 ENOG4107Z6I Thiamine biosynthesis protein At12D13_29990 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase At12D13_30000 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) At12D13_30030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) At12D13_30040 ENOG4105MWK D-amino acid dehydrogenase, small subunit At12D13_30110 ENOG4107QZ7 Cellulose synthase catalytic subunit At12D13_30130 ENOG4107SZR mannose-6-phosphate isomerase At12D13_30170 ENOG4105CMR udp-glucose 4-epimerase At12D13_30200 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_30230 ENOG4108JJ6 Type I secretion system ATPase At12D13_30300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) At12D13_30320 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein At12D13_30340 ENOG4105CHR reductase At12D13_30360 ENOG4108VX5 3-methyladenine DNA glycosylase At12D13_30390 ENOG4105FKQ transcriptional regulator At12D13_30400 ENOG4107T3P ABC, transporter At12D13_30430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_30450 ENOG4107RJ5 oxidoreductase At12D13_30460 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) At12D13_30470 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase At12D13_30480 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) At12D13_30490 ENOG4105D9R oxidoreductase At12D13_30520 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component At12D13_30530 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component At12D13_30570 ENOG4106NZI LysR family Transcriptional regulator At12D13_30580 ENOG4105C6K Malic enzyme At12D13_30610 ENOG4105DRP amino acid AbC transporter At12D13_30630 ENOG4108PGP mmge prpd family protein At12D13_30640 ENOG4105CPU Monooxygenase At12D13_30650 ENOG4107SDU Methyl-accepting chemotaxis At12D13_30660 ENOG4105MWK D-amino acid dehydrogenase, small subunit At12D13_30690 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ At12D13_30700 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_30710 ENOG4105CH5 extracellular solute-binding protein, family 7 At12D13_30720 ENOG4108Z86 Glutamine amidotransferase At12D13_30730 ENOG4105CNN ABC, transporter At12D13_30740 ENOG4105C2J ABC transporter At12D13_30760 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B At12D13_30800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_30820 ENOG4106P55 Transcriptional regulator At12D13_30880 ENOG4108KPJ rna polymerase sigma factor At12D13_30890 ENOG4105E0A ABC, transporter At12D13_30900 ENOG4105EHG Permease protein At12D13_30930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) At12D13_30950 ENOG4105E0A ABC, transporter At12D13_30960 ENOG4105EHG Permease protein At12D13_30990 ENOG4105CWC Acetylornithine deacetylase At12D13_31000 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase At12D13_31020 ENOG4105C26 Dehydrogenase At12D13_31030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) At12D13_31040 ENOG4105C26 Dehydrogenase At12D13_31050 ENOG4105CJP fad dependent oxidoreductase At12D13_31080 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) At12D13_31120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_31130 ENOG4108JQ6 ABC transporter At12D13_31140 ENOG4108RYR transcriptional regulator AsnC family At12D13_31150 ENOG4108DN8 FAD dependent oxidoreductase At12D13_31170 ENOG4105EAB amino acid AbC transporter At12D13_31180 ENOG4105CDA abc transporter atp-binding protein At12D13_31200 ENOG4105CH2 amidohydrolase At12D13_31220 ENOG4105DEN Luciferase family At12D13_31230 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family At12D13_31250 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) At12D13_31260 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) At12D13_31290 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) At12D13_31300 ENOG4105C1G acyl-Coa dehydrogenase At12D13_31370 ENOG4105CPC Aldo Keto reductase At12D13_31380 ENOG4107T8P acyl-Coa dehydrogenase At12D13_31390 ENOG4105ETT transcriptional Regulator, LysR family At12D13_31400 ENOG4105CPU Monooxygenase At12D13_31430 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_31440 ENOG4105CH2 amidohydrolase At12D13_31450 ENOG4105FBW Monooxygenase At12D13_31480 ENOG4105CPU Monooxygenase At12D13_31490 ENOG4108M8W Monooxygenase At12D13_31500 ENOG4105DIA mandelate racemase muconate lactonizing At12D13_31520 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_31530 ENOG4108JQ7 (ABC) transporter At12D13_31540 ENOG4105C3U ABC transporter At12D13_31560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_31580 ENOG4105JXH GntR family transcriptional regulator At12D13_31630 ENOG4107S76 domain protein At12D13_31640 ENOG41080HT Transcriptional regulator, arsr family At12D13_31660 ENOG4105KFG YeeE YedE family protein At12D13_31670 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) At12D13_31680 ENOG4107QSN dihydrolipoamide acetyltransferase At12D13_31690 ENOG4105CPP Dehydrogenase, E1 component At12D13_31700 ENOG4107R0V Pyruvate dehydrogenase At12D13_31710 ENOG4105C1G acyl-Coa dehydrogenase At12D13_31720 ENOG4105CHU acetyl-coa acetyltransferase At12D13_31730 ENOG4105J0Q Transcriptional regulator At12D13_31740 ENOG4105C1G acyl-Coa dehydrogenase At12D13_31750 ENOG4107QX3 carboxylase At12D13_31770 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase At12D13_31780 ENOG4108IPT Naphthoate synthase At12D13_31790 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) At12D13_31800 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) At12D13_31810 ENOG4105C9F isomerase At12D13_31830 ENOG4105E98 transcriptional regulator DeoR family At12D13_31850 ENOG4105C2J ABC transporter At12D13_31860 ENOG4105CNN ABC, transporter At12D13_31870 ENOG4105CNN ABC, transporter At12D13_31880 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) At12D13_31910 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) At12D13_31960 ENOG4105F1N DNA alkylation repair At12D13_31970 ENOG4108IJ6 ABC transporter At12D13_31980 ENOG4105ECW sulfate abc transporter At12D13_31990 ENOG4108I5D sulfate abc transporter At12D13_32000 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein At12D13_32040 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) At12D13_32070 ENOG4105VW4 glutaredoxin 3 At12D13_32080 ENOG41081UC Inherit from COG: Competence protein At12D13_32090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) At12D13_32120 ENOG4105M6F mutator MutT protein At12D13_32140 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) At12D13_32150 ENOG4105EIN peptidylprolyl cis-trans isomerase At12D13_32160 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving At12D13_32170 ENOG4105FDR Membrane At12D13_32240 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) At12D13_32250 ENOG4105DEI Mannitol dehydrogenase At12D13_32290 ENOG4105CNN ABC, transporter At12D13_32300 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane At12D13_32310 ENOG4105C2J ABC transporter At12D13_32370 ENOG4105CMT Dihydroxyacetone kinase At12D13_32420 ENOG4105E2K Glycosyl transferase (Group 1 At12D13_32540 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) At12D13_32580 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) At12D13_32680 ENOG4108WRK Transcriptional regulator At12D13_32700 ENOG4105C2J ABC transporter At12D13_32710 ENOG4107RNG ABC transporter At12D13_32720 ENOG4105DFW ABC transporter At12D13_32740 ENOG4105C6V Glycerol-3-phosphate dehydrogenase At12D13_32790 ENOG4105CYM Glutathione S-transferase At12D13_32800 ENOG4107QX3 carboxylase At12D13_32810 ENOG4105CFF transcriptional regulator At12D13_32830 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) At12D13_32850 ENOG4105E1F short-chain dehydrogenase reductase At12D13_32890 ENOG4105BZJ Electron transfer flavoprotein At12D13_32900 ENOG4105C10 Electron transfer flavoprotein At12D13_32910 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase At12D13_32920 ENOG4107ZT5 Thiol disulfide interchange protein At12D13_32930 ENOG4105CH7 arginosuccinase At12D13_32950 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) At12D13_32980 ENOG4108UGV hypoxanthine phosphoribosyltransferase At12D13_33000 ENOG4105CAK Cell division ATP-binding protein ftsE At12D13_33040 ENOG4108NH8 Cation transport protein At12D13_33080 ENOG4105CIH Imidazole acetol-phosphate transaminase At12D13_33090 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) At12D13_33100 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) At12D13_33130 ENOG4105KDC 50s ribosomal protein l28 At12D13_33140 ENOG4105EX9 Membrane At12D13_33200 ENOG4105D49 3-dehydroquinate synthase At12D13_33210 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) At12D13_33230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) At12D13_33240 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) At12D13_33250 ENOG4105F7V ErfK ybiS ycfS ynhG family protein At12D13_33260 ENOG4105VFE sira family At12D13_33280 ENOG4105CKI cobalamin synthesis protein At12D13_33290 ENOG4105DZ1 carboxypeptidase At12D13_33320 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) At12D13_33340 ENOG4107QI1 Mate efflux family protein At12D13_33400 ENOG4108D32 Methyltransferase At12D13_33470 ENOG4105CEY Amp-dependent synthetase and ligase At12D13_33510 ENOG4107RBR Receptor At12D13_33530 ENOG4105DQ5 transport system permease protein At12D13_33540 ENOG4105EHG Permease protein At12D13_33550 ENOG4105E0A ABC, transporter At12D13_33580 ENOG4108JQB penicillin-binding protein 1C At12D13_33590 ENOG4105DN3 alpha-2-macroglobulin domain protein At12D13_33600 ENOG4105W49 UPF0434 protein At12D13_33620 ENOG4105K63 Thioredoxin At12D13_33650 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) At12D13_33710 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) At12D13_33720 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) At12D13_33730 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) At12D13_33750 ENOG4105KCK Peptidoglycan-associated lipoprotein At12D13_33760 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) At12D13_33780 ENOG4105SG9 biopolymer transport protein, ExbD At12D13_33790 ENOG4105E02 MotA TolQ exbB proton channel At12D13_33800 ENOG4107YD3 Thioesterase At12D13_33820 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) At12D13_33850 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) At12D13_33860 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) At12D13_33870 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) At12D13_33890 ENOG4105DEN Luciferase family At12D13_33900 ENOG4105CDY transcriptional regulatory protein At12D13_33930 ENOG4105D48 metallophosphoesterase At12D13_34010 ENOG4105BZA Phosphoglycerate kinase At12D13_34020 ENOG4107R1Y fructose-bisphosphate aldolase At12D13_34070 ENOG41082FS 50S ribosomal protein L31 At12D13_34090 ENOG4105BZ1 (ABC) transporter At12D13_34120 ENOG4105UYK outer membrane protein a At12D13_34140 ENOG4105ECY inositol monophosphatase At12D13_34200 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) At12D13_34210 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit At12D13_34220 ENOG4105YK5 50S ribosomal protein L36 At12D13_34230 ENOG4105M0T TPR Repeat-Containing Protein At12D13_34240 ENOG4105Y2X UPF0335 protein At12D13_34280 ENOG4105CA9 Pyruvate kinase At12D13_34290 ENOG4105EAQ (twin-arginine translocation) pathway signal At12D13_34300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family At12D13_34310 ENOG4105DPN Oligoendopeptidase f At12D13_34320 ENOG4107Z5F Aminotransferase class IV At12D13_34340 ENOG4105FE5 Homospermidine synthase At12D13_34350 ENOG4105ZWB Outer membrane lipoprotein At12D13_34360 ENOG4105CGH 5'-nucleotidase At12D13_34370 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) At12D13_34380 ENOG4107QX8 SPFH domain, Band 7 family protein At12D13_34400 ENOG4105C2X Arabinose 5-phosphate isomerase At12D13_34440 ENOG4105CVE Lytic murein transglycosylase At12D13_34470 ENOG4106F60 Histidine kinase At12D13_34500 ENOG4105C5W Aldolase At12D13_34510 ENOG4105EEX Two component transcriptional regulator (Winged helix family At12D13_34520 ENOG4105C08 Histidine kinase At12D13_34530 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) At12D13_34540 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) At12D13_34560 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) At12D13_34580 ENOG4105HDK L-asparaginase At12D13_34600 ENOG4108IJ0 Aspartate ammonia-lyase At12D13_34610 ENOG41073TP transcriptional regulator At12D13_34620 ENOG4105BZS acriflavin resistance protein At12D13_34640 ENOG4105C1P efflux transporter, rnd family, mfp subunit At12D13_34660 ENOG4105CZE histidine utilization repressor At12D13_34690 ENOG4108HQS Glycine betaine At12D13_34700 ENOG4108IJ7 Glycine betaine At12D13_34710 ENOG4105C84 Histidine ammonia-lyase At12D13_34720 ENOG4107RTG Major Facilitator superfamily At12D13_34740 ENOG4105C28 cystathionine At12D13_34750 ENOG4105F7P transcriptional regulator AsnC family At12D13_34760 ENOG410642W LysR family Transcriptional regulator At12D13_34770 ENOG4107S5I aldo keto reductase At12D13_34780 ENOG4105JQN Transcriptional regulator At12D13_34790 ENOG4105CHJ isochorismatase hydrolase At12D13_34810 ENOG4106517 Short-chain dehydrogenase reductase Sdr At12D13_34820 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) At12D13_34850 ENOG4105CTX dehydratase At12D13_34860 ENOG4105C2J ABC transporter At12D13_34870 ENOG4105CNN ABC, transporter At12D13_34880 ENOG4105CNN ABC, transporter At12D13_34890 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator At12D13_34910 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) At12D13_34940 ENOG4105DZ2 Transcriptional regulator At12D13_35000 ENOG4105NAU thioesterase Superfamily protein At12D13_35040 ENOG4105NPQ Pfam:DUF403 At12D13_35070 ENOG4105C5H ABC transporter At12D13_35080 ENOG4105C5I Dehydrogenase At12D13_35090 ENOG4105DMF Dehydrogenase At12D13_35110 ENOG4108U05 Transcriptional regulator At12D13_35130 ENOG4105CMG Carbohydrate kinase At12D13_35140 ENOG41061GT Aldolase At12D13_35160 ENOG4108FN7 Aldo keto reductase At12D13_35180 ENOG4105CNN ABC, transporter At12D13_35190 ENOG4105C2J ABC transporter At12D13_35250 ENOG4108ZNX Heat shock protein At12D13_35260 ENOG4105DHU Bile acid At12D13_35280 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) At12D13_35310 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component At12D13_35340 ENOG4108IJ9 (ABC) transporter At12D13_35350 ENOG4105C6V Glycerol-3-phosphate dehydrogenase At12D13_35360 ENOG4105E98 transcriptional regulator DeoR family At12D13_35370 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) At12D13_35410 ENOG4108IFG nitrite reductase, (NAD(P)H) At12D13_35420 ENOG4105D7T ABC transporter At12D13_35470 ENOG4105DRR Transcriptional regulator, GntR family At12D13_35480 ENOG4105C5A transporter At12D13_35490 ENOG4105E7W lamb ycsf family protein At12D13_35500 ENOG4105CFM UPF0317 protein At12D13_35510 ENOG4107R7A Allophanate hydrolase subunit 2 At12D13_35520 ENOG4108JIK carboxylase At12D13_35530 ENOG4105E5K Alpha-amylase At12D13_35540 ENOG4108Z4X TRANSCRIPTIONal At12D13_35550 ENOG4105D05 Receptor At12D13_35560 ENOG4107QYG anthranilate phosphoribosyltransferase At12D13_35640 ENOG4105KME endoribonuclease L-psp At12D13_35690 ENOG4105CGP Urocanate hydratase At12D13_35720 ENOG4105C84 Histidine ammonia-lyase At12D13_35730 ENOG4105CI2 imidazolone-5-propionate hydrolase At12D13_35740 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) At12D13_35800 ENOG4105CJP fad dependent oxidoreductase At12D13_35840 ENOG4105EJC lysr family transcriptional regulator At12D13_35850 ENOG4105DDR sarcosine oxidase (Beta subunit) At12D13_35860 ENOG4105CTU Proline racemase At12D13_35870 ENOG4108HQS Glycine betaine At12D13_35890 ENOG4108IJ7 Glycine betaine At12D13_35910 ENOG4105CJP fad dependent oxidoreductase At12D13_35920 ENOG4105C26 Dehydrogenase At12D13_35930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_35990 ENOG4105D9R oxidoreductase At12D13_36000 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) At12D13_36020 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component At12D13_36030 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component At12D13_36060 ENOG4105E9Z Nad-dependent epimerase dehydratase At12D13_36070 ENOG4105JSC dimethylmenaquinone methyltransferase At12D13_36130 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase At12D13_36160 ENOG4105EFZ amidohydrolase At12D13_36180 ENOG4107SFI Major Facilitator superfamily At12D13_36210 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_36220 ENOG4105C57 major facilitator superfamily At12D13_36310 ENOG4105K5X acetyltransferase At12D13_36320 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) At12D13_36340 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) At12D13_36350 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) At12D13_36360 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) At12D13_36430 ENOG4105DFI Membrane At12D13_36450 ENOG4105F8J Adenylate Guanylate cyclase At12D13_36480 ENOG4105CSH Transporter At12D13_36490 ENOG4105ECM Sensor protein basS pmrB At12D13_36500 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_36510 ENOG4105DIJ Phosphoethanolamine transferase At12D13_36530 ENOG4106NZI LysR family Transcriptional regulator At12D13_36540 ENOG4105E0K tonB-dependent siderophore receptor At12D13_36560 ENOG4105S6R Iron-hydroxamate transporter permease subunit At12D13_36570 ENOG4105E0A ABC, transporter At12D13_36590 ENOG4105G9V cytochrome C At12D13_36640 ENOG4105C2J ABC transporter At12D13_36650 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator At12D13_36660 ENOG4105BZU Histidine kinase At12D13_36670 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_36690 ENOG4105D8V Glucose sorbosone dehydrogenase At12D13_36710 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) At12D13_36720 ENOG4105D3G Pseudouridine synthase At12D13_36740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase At12D13_36750 ENOG4108IJ7 Glycine betaine At12D13_36760 ENOG4108HQS Glycine betaine At12D13_36780 ENOG4105BZU Histidine kinase At12D13_36790 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase At12D13_36950 ENOG4105K5G 30S ribosomal protein S21 At12D13_36960 ENOG4105DDR sarcosine oxidase (Beta subunit) At12D13_36990 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) At12D13_37040 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 At12D13_37050 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) At12D13_37060 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) At12D13_37070 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) At12D13_37080 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) At12D13_37110 ENOG4108UYU AsnC family transcriptional regulator At12D13_37130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase At12D13_37140 ENOG4105CHR reductase At12D13_37150 ENOG4105CPQ Dehydrogenase At12D13_37170 ENOG4108JJ9 ABC, transporter At12D13_37180 ENOG4108JJ8 (ABC) transporter At12D13_37190 ENOG4105C4M (Ubiquinol oxidase) subunit I At12D13_37200 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii At12D13_37250 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase At12D13_37260 ENOG4108IYU L-aspartate oxidase At12D13_37270 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) At12D13_37320 ENOG4105CAT Cytidine monophosphate kinase At12D13_37330 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) At12D13_37390 ENOG4105EMU Dehydrogenase At12D13_37400 ENOG4105DC7 peptidase M24 At12D13_37410 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_37420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_37430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_37440 ENOG4105C3U ABC transporter At12D13_37450 ENOG4108JQ7 (ABC) transporter At12D13_37470 ENOG4105DIA mandelate racemase muconate lactonizing At12D13_37510 ENOG4105C0Z ABC transporter At12D13_37520 ENOG4108IV0 ABC, transporter At12D13_37530 ENOG4105C32 Amino acid ABC transporter (Permease) At12D13_37540 ENOG4105CF8 branched-chain amino acid ABC transporter, permease At12D13_37570 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) At12D13_37620 ENOG4105DZG Dehydrogenase At12D13_37630 ENOG4108Z9Z response to DNA damage stimulus At12D13_37690 ENOG4108Z0Z intracellular protease Pfpi family At12D13_37740 ENOG4105D7Z glutathione synthase At12D13_37750 ENOG4105C1B dTDP-glucose 4-6-dehydratase At12D13_37760 ENOG4105C6Y Udp-glucose 6-dehydrogenase At12D13_37780 ENOG4105ETT transcriptional Regulator, LysR family At12D13_37790 ENOG4105C26 Dehydrogenase At12D13_37800 ENOG4105GVF (ABC) transporter At12D13_37810 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component At12D13_37820 ENOG4105E2Y ABC, transporter At12D13_37840 ENOG4105EW9 transcriptional regulator AsnC family At12D13_37870 ENOG41074H6 response regulator At12D13_37890 ENOG410903D sensor protein At12D13_37940 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) At12D13_37960 ENOG4105C1J atp-dependent rna helicase At12D13_37970 ENOG4105CFH Aspartokinase At12D13_37980 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase At12D13_37990 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) At12D13_38000 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) At12D13_38020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit At12D13_38030 ENOG4105E4C Lytic transglycosylase catalytic At12D13_38070 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase At12D13_38090 ENOG41073TP transcriptional regulator At12D13_38110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_38120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_38130 ENOG4108JQ6 ABC transporter At12D13_38140 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_38180 ENOG4105E7W lamb ycsf family protein At12D13_38190 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein At12D13_38200 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase At12D13_38220 ENOG4107R7A Allophanate hydrolase subunit 2 At12D13_38240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_38250 ENOG4105F38 ABC transporter, permease At12D13_38270 ENOG4105CHR reductase At12D13_38280 ENOG4105CHR reductase At12D13_38300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_38310 ENOG410819M Polysaccharide deacetylase At12D13_38330 ENOG4105CKI cobalamin synthesis protein At12D13_38400 ENOG4108V1U phospholipid-binding protein At12D13_38460 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) At12D13_38470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) At12D13_38510 ENOG4108IXY short-chain dehydrogenase reductase At12D13_38530 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) At12D13_38540 ENOG4105WIU sarcosine oxidase delta subunit At12D13_38550 ENOG4105DDR sarcosine oxidase (Beta subunit) At12D13_38560 ENOG4105ECQ AraC Family Transcriptional Regulator At12D13_38580 ENOG4105EYU Glutamine amido-transferase At12D13_38590 ENOG4105M90 Glutamate synthase alpha subunit domain protein At12D13_38600 ENOG4105CBC glutamate synthase At12D13_38610 ENOG4105C5F glutamine synthetase At12D13_38650 ENOG4105E5Q amino acid AbC transporter At12D13_38660 ENOG4105CDA abc transporter atp-binding protein At12D13_38670 ENOG4105C0A alcohol dehydrogenase At12D13_38690 ENOG4108MXF Alpha Beta Hydrolase At12D13_38710 ENOG4108M8W Monooxygenase At12D13_38720 ENOG4105C26 Dehydrogenase At12D13_38750 ENOG4105F38 ABC transporter, permease At12D13_38760 ENOG4105D38 putrescine abc transporter At12D13_38770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_38780 ENOG4105C26 Dehydrogenase At12D13_38810 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component At12D13_38820 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component At12D13_38850 ENOG4107P2S Transcriptional regulator At12D13_38860 ENOG4108JQ5 ABC transporter At12D13_38870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_38880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_38890 ENOG4108J59 Extracellular solute-binding protein, family 5 At12D13_38900 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component At12D13_38930 ENOG4105C7F AcnD-accessory protein PrpF At12D13_38940 ENOG4105F04 LysR family Transcriptional regulator At12D13_38960 ENOG4107U9B transcriptional regulator At12D13_38980 ENOG4105E82 cytochrome subunit of dehydrogenase At12D13_38990 ENOG4105JAB phenazine biosynthesis protein, phzf family At12D13_39000 ENOG4107VIJ nudix hydrolase At12D13_39010 ENOG4105HEI LysR family (Transcriptional regulator At12D13_39030 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein At12D13_39040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase At12D13_39070 ENOG4107R7A Allophanate hydrolase subunit 2 At12D13_39080 ENOG4105E7W lamb ycsf family protein At12D13_39090 ENOG4105CHM Aminotransferase At12D13_39120 ENOG4105DRP amino acid AbC transporter At12D13_39130 ENOG4105DRP amino acid AbC transporter At12D13_39140 ENOG4105CDA abc transporter atp-binding protein At12D13_39150 ENOG4107R0W ABC transporter At12D13_39160 ENOG4105JSC dimethylmenaquinone methyltransferase At12D13_39190 ENOG4105HEI LysR family (Transcriptional regulator At12D13_39200 ENOG4107QPD alcohol dehydrogenase At12D13_39210 ENOG4105HEI LysR family (Transcriptional regulator At12D13_39220 ENOG4105F27 Major Facilitator At12D13_39230 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) At12D13_39240 ENOG4105CV8 reductase At12D13_39250 ENOG4105E2X shikimate dehydrogenase At12D13_39270 ENOG4108R6W Transcriptional regulator, ARAC family At12D13_39280 ENOG4105D8X mechanosensitive ion channel At12D13_39300 ENOG4108ZXC Two component transcriptional regulator, luxr family At12D13_39340 ENOG4105D64 Mechanosensitive ion channel At12D13_39350 ENOG4105BZU Histidine kinase At12D13_39360 ENOG4105BZU Histidine kinase At12D13_39370 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) At12D13_39400 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) At12D13_39410 ENOG4105BZ9 Cytochrome C oxidase, subunit I At12D13_39450 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I At12D13_39460 ENOG4105DDR sarcosine oxidase (Beta subunit) At12D13_39480 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) At12D13_39500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) At12D13_39530 ENOG4108IG5 Transcriptional regulator At12D13_39540 ENOG4105CPQ Dehydrogenase At12D13_39560 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator At12D13_39580 ENOG4105CNN ABC, transporter At12D13_39600 ENOG4105EF1 ribulokinase At12D13_39620 ENOG4105CSH Transporter At12D13_39680 ENOG4105UYK outer membrane protein a At12D13_39790 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit At12D13_39830 ENOG4105CS6 Rhs element vgr protein At12D13_39900 ENOG4105EE5 Membrane protein terC At12D13_39940 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_39950 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component At12D13_39970 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) At12D13_39990 ENOG4105FKQ transcriptional regulator At12D13_40020 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator At12D13_40030 ENOG4105C2J ABC transporter At12D13_40040 ENOG4105CNN ABC, transporter At12D13_40050 ENOG4105CNN ABC, transporter At12D13_40060 ENOG4105ETE Transcriptional regulator (LacI family At12D13_40200 ENOG4105GMT ATPase associated with various cellular activities aaa_5 At12D13_40240 ENOG4105CCU oxidase (Subunit III) At12D13_40270 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase At12D13_40280 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) At12D13_40290 ENOG4105K78 MarR family Transcriptional regulator At12D13_40310 ENOG4105CFP Peptidase U32 At12D13_40370 ENOG4108ETV ABC transporter At12D13_40420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) At12D13_40460 ENOG4108TSE Transferase At12D13_40470 ENOG4105C1G acyl-Coa dehydrogenase At12D13_40480 ENOG4105ETT transcriptional Regulator, LysR family At12D13_40490 ENOG4105ETE Transcriptional regulator (LacI family At12D13_40510 ENOG4105F38 ABC transporter, permease At12D13_40530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_40550 ENOG4105CPN adenine deaminase At12D13_40570 ENOG4105CH2 amidohydrolase At12D13_40590 ENOG4108IGT Dipeptidase At12D13_40600 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_40610 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_40620 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_40630 ENOG4105C3U ABC transporter At12D13_40640 ENOG4108JQ7 (ABC) transporter At12D13_40650 ENOG4108M0I Transcriptional regulator At12D13_40660 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_40680 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_40690 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) At12D13_40700 ENOG4107R7Y intracellular protease Pfpi family At12D13_40720 ENOG4105CH2 amidohydrolase At12D13_40730 ENOG4108JQ6 ABC transporter At12D13_40740 ENOG4105DKT Transcriptional regulator At12D13_40780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_40790 ENOG4105DEI Mannitol dehydrogenase At12D13_40800 ENOG4107URF beta-phospho-glucomutase At12D13_40810 ENOG4105EF1 ribulokinase At12D13_40820 ENOG4106KNT transcriptional regulator At12D13_40860 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) At12D13_40880 ENOG4105DKT Transcriptional regulator At12D13_40890 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) At12D13_40900 ENOG4107258 Transcriptional regulator At12D13_40910 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr At12D13_40930 ENOG4105CC5 ABC transporter At12D13_40940 ENOG4105CC5 ABC transporter At12D13_40950 ENOG4105DIK (ABC) transporter At12D13_40960 ENOG4105DSE periplasmic solute binding protein At12D13_40980 ENOG4105CRK lysyL-tRNA synthetase At12D13_40990 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) At12D13_41010 ENOG4105EE5 Membrane protein terC At12D13_41070 ENOG4105CMG Carbohydrate kinase At12D13_41080 ENOG4105C93 Xylose Isomerase At12D13_41100 ENOG4108DBC nitroreductase At12D13_41110 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) At12D13_41120 ENOG4108UMI ABC transporter, permease At12D13_41130 ENOG4105D01 (LipO)protein At12D13_41140 ENOG4105BZU Histidine kinase At12D13_41150 ENOG4105C72 UPF0176 protein At12D13_41170 ENOG41080ZE Adenylate cyclase At12D13_41180 ENOG4108UHU Aldolase At12D13_41220 ENOG4105D7X high-affinity nickel-transporter At12D13_41290 ENOG4105CKI cobalamin synthesis protein At12D13_41310 ENOG4107MII Sugar-specific transcriptional regulator TrmB At12D13_41320 ENOG4105ETE Transcriptional regulator (LacI family At12D13_41330 ENOG4105C5I Dehydrogenase At12D13_41350 ENOG4105DH8 myo-inositol catabolism At12D13_41370 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) At12D13_41380 ENOG4105EDK PfkB domain protein At12D13_41400 ENOG4108IV0 ABC, transporter At12D13_41410 ENOG4105C0Z ABC transporter At12D13_41440 ENOG4105CAD extracellular ligand-binding receptor At12D13_41480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_41500 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein At12D13_41560 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) At12D13_41570 ENOG4107S9B Shikimate dehydrogenase At12D13_41580 ENOG4105CDA abc transporter atp-binding protein At12D13_41590 ENOG4105CT1 (ABC) transporter At12D13_41600 ENOG4105CT1 (ABC) transporter At12D13_41610 ENOG4105E5Q amino acid AbC transporter At12D13_41620 ENOG4105E5Q amino acid AbC transporter At12D13_41630 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase At12D13_41640 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha At12D13_41650 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta At12D13_41660 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase At12D13_41680 ENOG4105DDW LysR family Transcriptional regulator At12D13_41690 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase At12D13_41710 ENOG4107HP6 Transcriptional regulator At12D13_41730 ENOG4107QNJ CoA-transferase subunit B At12D13_41740 ENOG4105CHU acetyl-coa acetyltransferase At12D13_41750 ENOG4105ETE Transcriptional regulator (LacI family At12D13_41780 ENOG4105F0H myo-inositol catabolism protein At12D13_41790 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) At12D13_41810 ENOG4105ETE Transcriptional regulator (LacI family At12D13_41820 ENOG4105DRS transport system, permease At12D13_41840 ENOG4108IJ9 (ABC) transporter At12D13_41860 ENOG4105F5H Glycosyl Hydrolase Family 88 At12D13_41900 ENOG4105E2R ROK family At12D13_41920 ENOG4108IJ9 (ABC) transporter At12D13_41930 ENOG4105E0C molybdate abc transporter At12D13_41950 ENOG4108QXE glycerophosphoryl diester phosphodiesterase At12D13_41970 ENOG4108W6C Dehydrogenase At12D13_42010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_42020 ENOG4108I5D sulfate abc transporter At12D13_42060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) At12D13_42120 ENOG4107R3N Filamentation induced by cAMP protein fic At12D13_42180 ENOG4105C09 Bile acid At12D13_42190 ENOG4105CPC Aldo Keto reductase At12D13_42200 ENOG4105HEI LysR family (Transcriptional regulator At12D13_42220 ENOG4105ERH Fumarylacetoacetate hydrolase At12D13_42240 ENOG4106517 Short-chain dehydrogenase reductase Sdr At12D13_42260 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component At12D13_42280 ENOG41069M3 Transcriptional regulator At12D13_42420 ENOG4105C4R Atp-dependent dna helicase At12D13_42430 ENOG4108JQ7 (ABC) transporter At12D13_42450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_42460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_42470 ENOG4107YCY Transcriptional regulator At12D13_42480 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) At12D13_42490 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_42510 ENOG4105BZU Histidine kinase At12D13_42520 ENOG4105CYX Short-chain dehydrogenase reductase Sdr At12D13_42540 ENOG4105FDF Could be involved in DNA repair (By similarity) At12D13_42550 ENOG4105DQE DNA ligase At12D13_42560 ENOG4105FDF Could be involved in DNA repair (By similarity) At12D13_42570 ENOG4107QXV Phosphate transporter At12D13_42580 ENOG4107GRR phosphate transport regulator At12D13_42620 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_42630 ENOG4105GR3 Histidine kinase At12D13_42660 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) At12D13_42720 ENOG4105CBG Sulfatase At12D13_42730 ENOG4108RVA ribokinase At12D13_42750 ENOG4106IQC argininosuccinate lyase At12D13_42760 ENOG4105DRS transport system, permease At12D13_42780 ENOG4107FKK extracellular solute-binding protein family 1 At12D13_42790 ENOG4107TFG D-allose kinase At12D13_42880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_42890 ENOG4108JQ5 ABC transporter At12D13_42900 ENOG4105F8D glycoside hydrolase family 4 At12D13_42910 ENOG4105D0S secretion protein (HlyD At12D13_42920 ENOG4105CJ1 ABC, transporter At12D13_42930 ENOG4105CMI transporter At12D13_42960 ENOG41074H6 response regulator At12D13_42970 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) At12D13_42990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_43000 ENOG4105DG4 malate L-lactate dehydrogenase At12D13_43030 ENOG4105E5Q amino acid AbC transporter At12D13_43040 ENOG4105E5Q amino acid AbC transporter At12D13_43080 ENOG4105CTU Proline racemase At12D13_43090 ENOG4105ETE Transcriptional regulator (LacI family At12D13_43110 ENOG4105CT1 (ABC) transporter At12D13_43120 ENOG4105E5Q amino acid AbC transporter At12D13_43130 ENOG4105E5Q amino acid AbC transporter At12D13_43150 ENOG4105C5I Dehydrogenase At12D13_43160 ENOG4105BZU Histidine kinase At12D13_43180 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) At12D13_43200 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_43210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_43230 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) At12D13_43240 ENOG4105C3U ABC transporter At12D13_43250 ENOG4108JQ7 (ABC) transporter At12D13_43260 ENOG4105DRR Transcriptional regulator, GntR family At12D13_43270 ENOG4107XWI flavin reductase domain protein, FMN-binding At12D13_43280 ENOG410633P Hydantoin racemase At12D13_43310 ENOG4107QIZ NADH dehydrogenase At12D13_43320 ENOG4108JB9 formate dehydrogenase At12D13_43340 ENOG4105FCD Major Facilitator At12D13_43350 ENOG4105F3H Histidine kinase At12D13_43360 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_43410 ENOG41067RQ csbd family At12D13_43420 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_43430 ENOG410903D sensor protein At12D13_43440 ENOG4108QBF Transcriptional regulator At12D13_43450 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_43470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_43480 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) At12D13_43490 ENOG4108JQ6 ABC transporter At12D13_43520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) At12D13_43540 ENOG4108JJ7 ABC transporter At12D13_43600 ENOG4107QIJ Aconitate hydratase 2 At12D13_43630 ENOG4105EQK -acetyltransferase At12D13_43660 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family At12D13_43700 ENOG4105C2J ABC transporter At12D13_43710 ENOG4105CNN ABC, transporter At12D13_43720 ENOG4105F5R ABC transporter At12D13_43730 ENOG4107TTA Xylose isomerase domain protein TIM barrel At12D13_43750 ENOG4107TTA Xylose isomerase domain protein TIM barrel At12D13_43810 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase At12D13_43820 ENOG4105ENR peptidase, M24 At12D13_43870 ENOG4105C26 Dehydrogenase At12D13_43930 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) At12D13_43950 ENOG4105F0F Oxalate decarboxylase At12D13_43980 ENOG4108ZXC Two component transcriptional regulator, luxr family At12D13_44000 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit At12D13_44050 ENOG4105CIR epoxide hydrolase At12D13_44080 ENOG4108ZHJ Organic hydroperoxide resistance protein At12D13_44090 ENOG4105E0F Histidine kinase At12D13_44100 ENOG4105DPZ Two component transcriptional regulator (Winged helix family At12D13_44180 ENOG4105CQZ Histidine kinase At12D13_44190 ENOG4105DPZ Two component transcriptional regulator (Winged helix family At12D13_44200 ENOG4105C4Y ABC transporter At12D13_44210 ENOG4105C4Y ABC transporter At12D13_44220 ENOG4107RCV ABC transporter, permease At12D13_44230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_44240 ENOG4105ECY inositol monophosphatase At12D13_44280 ENOG4107F2M hemolysin-type calcium-binding region At12D13_44320 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_44330 ENOG4105FJR Lmbe family At12D13_44340 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase At12D13_44370 ENOG4105EQQ protein containing aminopeptidase domain At12D13_44380 ENOG4105C1B dTDP-glucose 4-6-dehydratase At12D13_44390 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase At12D13_44400 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase At12D13_44410 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_44420 ENOG4108ZXC Two component transcriptional regulator, luxr family At12D13_44480 ENOG4105ESV Glycosyl transferase, family 4 At12D13_44520 ENOG4107STW synthase At12D13_44530 ENOG4107T8Q Glycosyl transferase (Group 1 At12D13_44550 ENOG4105EW9 transcriptional regulator AsnC family At12D13_44610 ENOG4105CHU acetyl-coa acetyltransferase At12D13_44620 ENOG4108FUF Transcriptional regulator, IclR family At12D13_44650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit At12D13_44690 ENOG4108J5G 6-phosphogluconate dehydrogenase At12D13_44820 ENOG4105CDA abc transporter atp-binding protein At12D13_44830 ENOG4106TNF Periplasmic binding protein At12D13_44840 ENOG4105ETE Transcriptional regulator (LacI family At12D13_44930 ENOG4105ESI atpase involved in dna repair At12D13_44960 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) At12D13_45060 ENOG4107SET aldo keto reductase At12D13_45080 ENOG4105F9N Major Facilitator Superfamily At12D13_45110 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_45120 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit At12D13_45130 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding At12D13_45140 ENOG4105C7W Xanthine dehydrogenase At12D13_45150 ENOG4107XAN XdhC and CoxI family At12D13_45160 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) At12D13_45200 ENOG4105ENX hydrolase At12D13_45210 ENOG4107RTG Major Facilitator superfamily At12D13_45220 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_45260 ENOG4105N14 lysine exporter protein LysE YggA At12D13_45280 ENOG4105WH1 Two component transcriptional regulator luxr family At12D13_45290 ENOG4105ENE Histidine kinase At12D13_45310 ENOG4107T8P acyl-Coa dehydrogenase At12D13_45320 ENOG4105KVH Transcriptional regulator At12D13_45410 ENOG4105EQ2 LysR family Transcriptional regulator At12D13_45420 ENOG4105ENX hydrolase At12D13_45430 ENOG4105ENX hydrolase At12D13_45510 ENOG4105BZ1 (ABC) transporter At12D13_45540 ENOG410903D sensor protein At12D13_45570 ENOG41074H6 response regulator At12D13_45610 ENOG4105W3H MtN3 and saliva related transmembrane protein At12D13_45680 ENOG4108Z9Z response to DNA damage stimulus At12D13_45750 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) At12D13_45920 ENOG4107KJX Transcriptional regulator At12D13_45940 ENOG4107SDZ Galactoside transport system permease protein mglC At12D13_45950 ENOG4105C2J ABC transporter At12D13_45970 ENOG4105CK5 oxidoreductase At12D13_45980 ENOG4108JQ7 (ABC) transporter At12D13_46000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_46010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_46020 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_46030 ENOG4105DRR Transcriptional regulator, GntR family At12D13_46050 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_46060 ENOG4105EMY transcriptional regulator At12D13_46070 ENOG4108K3A Glutathione S-transferase At12D13_46170 ENOG4108ZNX Heat shock protein At12D13_46200 ENOG4105DQE DNA ligase At12D13_46230 ENOG4105BZ7 extracellular solute-binding protein family 1 At12D13_46240 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component At12D13_46250 ENOG4105DRS transport system, permease At12D13_46270 ENOG4108IJ9 (ABC) transporter At12D13_46280 ENOG4108Q3X Transcriptional regulator At12D13_46290 ENOG4105K56 Transcriptional regulator At12D13_46320 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_46340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component At12D13_46350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component At12D13_46360 ENOG4105DEF Extracellular solute-binding protein, family 5 At12D13_46390 ENOG4105C0A alcohol dehydrogenase At12D13_46400 ENOG41073TP transcriptional regulator At12D13_46410 ENOG4107S2N Type III effector Hrp-dependent At12D13_46420 ENOG4105ETE Transcriptional regulator (LacI family At12D13_46520 ENOG410903D sensor protein At12D13_46530 ENOG410642W LysR family Transcriptional regulator At12D13_46540 ENOG4105D74 hydrolase At12D13_46630 ENOG4105DHQ Histidine kinase At12D13_46640 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_46670 ENOG4105BZN citrate synthase At12D13_46680 ENOG4105BZN citrate synthase At12D13_46710 ENOG4105E0K tonB-dependent siderophore receptor At12D13_46720 ENOG4108MES Periplasmic binding protein At12D13_46740 ENOG4105DQ5 transport system permease protein At12D13_46750 ENOG4105TVJ transport system, permease At12D13_46760 ENOG4105E0A ABC, transporter At12D13_46790 ENOG4108A65 Transcriptional regulator At12D13_46800 ENOG4105CAU Arsenical resistance protein, ArsH At12D13_46830 ENOG4105EXG Transcriptional regulator At12D13_46840 ENOG4105C5Q Transcriptional regulator At12D13_46850 ENOG4108JQ1 Dehydrogenase At12D13_46860 ENOG4105JSC dimethylmenaquinone methyltransferase At12D13_46900 ENOG4105C5I Dehydrogenase At12D13_46940 ENOG4105BZU Histidine kinase At12D13_47050 ENOG4107S78 Band 7 protein At12D13_47080 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr At12D13_47090 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr At12D13_47100 ENOG4105SKE transcriptional Regulator LysR family At12D13_47140 ENOG4105RQF LysR family Transcriptional regulator At12D13_47160 ENOG4105F38 ABC transporter, permease At12D13_47170 ENOG4105D38 putrescine abc transporter At12D13_47180 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) At12D13_47190 ENOG4105E1J oxidoreductase At12D13_47230 ENOG4107R73 Mate efflux family protein At12D13_47270 ENOG4107P2S Transcriptional regulator At12D13_47280 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) At12D13_47290 ENOG4105CIB oxidoreductase Domain protein At12D13_47300 ENOG4105F0H myo-inositol catabolism protein At12D13_47310 ENOG4105KVH Transcriptional regulator At12D13_47320 ENOG4105CHR reductase At12D13_47390 ENOG4105EMU Dehydrogenase At12D13_47400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase At12D13_47410 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) At12D13_47420 ENOG4105CIS alcohol dehydrogenase At12D13_47440 ENOG4108ZNX Heat shock protein At12D13_47500 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 At12D13_47510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) At12D13_47520 ENOG4105CXK mandelate racemase muconate lactonizing At12D13_47540 ENOG4105D56 permease protein At12D13_47550 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component At12D13_47560 ENOG4108IJ9 (ABC) transporter At12D13_47570 ENOG4105CMR udp-glucose 4-epimerase At12D13_47580 ENOG4108FUF Transcriptional regulator, IclR family At12D13_47590 ENOG4105CHR reductase At12D13_47650 ENOG4105F0I Aminotransferase At12D13_47680 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) At12D13_47700 ENOG4105DTQ mandelate racemase muconate lactonizing At12D13_47710 ENOG4107PP3 Acetylornithine deacetylase At12D13_47730 ENOG4105DRP amino acid AbC transporter At12D13_47740 ENOG4105EAB amino acid AbC transporter At12D13_47860 ENOG4108Z9Z response to DNA damage stimulus At12D13_47890 ENOG4108SGK Tetr family transcriptional regulator At12D13_47900 ENOG4107XAN XdhC and CoxI family At12D13_47910 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit At12D13_47920 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding At12D13_47930 ENOG4105C7W Xanthine dehydrogenase At12D13_47940 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) At12D13_47990 ENOG4105XJC Two component transcriptional regulator (Winged helix family At12D13_48030 ENOG4105BZU Histidine kinase At12D13_48110 ENOG4107T8P acyl-Coa dehydrogenase At12D13_48120 ENOG4108IV0 ABC, transporter At12D13_48140 ENOG4105CNN ABC, transporter At12D13_48160 ENOG4105C0Z ABC transporter At12D13_48170 ENOG4105FBW Monooxygenase At12D13_48180 ENOG4108UZX fmn reductase At12D13_48190 ENOG410903D sensor protein At12D13_48200 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein At12D13_48220 ENOG4105CP9 extracellular ligand-binding receptor At12D13_48230 ENOG4105C32 Amino acid ABC transporter (Permease) At12D13_48250 ENOG4105C0Z ABC transporter At12D13_48280 ENOG4107QN2 dihydrolipoyl dehydrogenase At12D13_48300 ENOG4105Y49 secretion protein, HlyD family At12D13_48340 ENOG4105R1U AraC Family Transcriptional Regulator At12D13_48470 ENOG4105DRS transport system, permease At12D13_48540 ENOG4105J0C At12D13_48600 ENOG4105BZU Histidine kinase At12D13_48670 ENOG4105BZ9 Cytochrome C oxidase, subunit I At12D13_48680 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) At12D13_48700 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit At12D13_48720 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) At12D13_48730 ENOG4105BZ9 Cytochrome C oxidase, subunit I At12D13_48830 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase At12D13_48850 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) At12D13_48880 ENOG4107E6A Cytochrome p-450 At12D13_48940 ENOG4108Z9Z response to DNA damage stimulus At12D13_48990 ENOG4108UN4 phage SPO1 DNA polymerase-related protein At12D13_49010 ENOG4108IAJ Nad-dependent epimerase dehydratase At12D13_49060 ENOG4108IAJ Nad-dependent epimerase dehydratase At12D13_49170 ENOG4105CYX Short-chain dehydrogenase reductase Sdr At12D13_49260 ENOG4107R3N Filamentation induced by cAMP protein fic At12D13_49310 ENOG4105BZU Histidine kinase At12D13_49330 ENOG4105BZU Histidine kinase At12D13_49340 ENOG41074H6 response regulator At12D13_49380 ENOG4105CC0 LysR family Transcriptional regulator At12D13_49400 ENOG4105HEI LysR family (Transcriptional regulator At12D13_49410 ENOG4108ZNX Heat shock protein At12D13_49420 ENOG4105VN1 Heat shock protein At12D13_49440 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) At12D13_49650 ENOG4105BZU Histidine kinase At12D13_50180 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) At12D13_50250 ENOG4105Y2X UPF0335 protein At12D13_50440 ENOG4105CIR epoxide hydrolase