locus-tag	class	description
At12D13_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
At12D13_00020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D13_00030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
At12D13_00040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
At12D13_00050	COG1420	regulation of RNA biosynthetic process
At12D13_00060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
At12D13_00070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_00080	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
At12D13_00100	COG1137	ATPase activity
At12D13_00110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
At12D13_00130	COG0616	signal peptide processing
At12D13_00140	COG0776	regulation of translation
At12D13_00170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D13_00180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
At12D13_00210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
At12D13_00220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
At12D13_00230	COG0728	peptidoglycan biosynthetic process
At12D13_00250	COG0180	Tryptophanyl-tRNA synthetase
At12D13_00270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
At12D13_00280	COG1214	PFAM Peptidase M22, glycoprotease
At12D13_00290	COG0456	acetyltransferase
At12D13_00320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D13_00330	COG1702	phosphate starvation-inducible protein PhoH
At12D13_00340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
At12D13_00360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
At12D13_00370	COG1396	sequence-specific DNA binding
At12D13_00380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
At12D13_00390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
At12D13_00400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_00420	COG0242	peptide deformylase activity
At12D13_00430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
At12D13_00440	COG0101	tRNA pseudouridine synthase activity
At12D13_00460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_00470	COG2171	N-acyltransferase activity
At12D13_00490	COG0840	transmembrane signaling receptor activity
At12D13_00510	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_00560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
At12D13_00580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
At12D13_00590	COG0706	membrane insertase activity
At12D13_00600	COG0594	ribonuclease P activity
At12D13_00610	COG0840	transmembrane signaling receptor activity
At12D13_00660	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_00710	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
At12D13_00750	COG2226	methyltransferase
At12D13_00760	COG3842	ATPase activity
At12D13_00770	COG1175	transmembrane transport
At12D13_00780	COG0395	ABC-type sugar transport system, permease component
At12D13_00810	COG0427	acetyl-CoA hydrolase
At12D13_00830	COG3938	Belongs to the proline racemase family
At12D13_00840	COG0418	dihydroorotase activity
At12D13_00850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
At12D13_00890	COG0166	Belongs to the GPI family
At12D13_00900	COG0318	PFAM AMP-dependent synthetase and ligase
At12D13_00910	COG3842	ATPase activity
At12D13_00920	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_00930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D13_00950	COG4774	siderophore transport
At12D13_01070	COG2326	polyphosphate kinase activity
At12D13_01080	COG5002	protein histidine kinase activity
At12D13_01090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
At12D13_01100	COG0573	inorganic phosphate transmembrane transporter activity
At12D13_01120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
At12D13_01130	COG0704	Plays a role in the regulation of phosphate uptake
At12D13_01140	COG0745	RESPONSE REGULATOR receiver
At12D13_01160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
At12D13_01170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
At12D13_01180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
At12D13_01190	COG2967	ApaG domain
At12D13_01210	COG0717	Belongs to the dCTP deaminase family
At12D13_01220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
At12D13_01260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
At12D13_01360	COG0167	dihydroorotate dehydrogenase activity
At12D13_01390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_01430	COG1959	2 iron, 2 sulfur cluster binding
At12D13_01440	COG1201	RNA secondary structure unwinding
At12D13_01480	COG0730	response to heat
At12D13_01500	COG1960	acyl-CoA dehydrogenase activity
At12D13_01510	COG0183	Belongs to the thiolase family
At12D13_01520	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D13_01520	COG1024	Enoyl-CoA hydratase
At12D13_01550	COG1320	monovalent cation:proton antiporter activity
At12D13_01560	COG2212	antiporter activity
At12D13_01570	COG1863	multisubunit Na H antiporter MnhE subunit
At12D13_01580	COG0651	ATP synthesis coupled electron transport
At12D13_01590	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D13_01600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
At12D13_01600	COG2111	Na H antiporter
At12D13_01620	COG0840	transmembrane signaling receptor activity
At12D13_01650	COG2198	Histidine kinase
At12D13_01650	COG0643	Histidine kinase
At12D13_01660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
At12D13_01670	COG2201	protein-glutamate methylesterase activity
At12D13_01680	COG0745	RESPONSE REGULATOR receiver
At12D13_01690	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
At12D13_01710	COG1766	The M ring may be actively involved in energy transduction
At12D13_01720	COG2771	luxR family
At12D13_01740	COG2972	Histidine kinase
At12D13_01740	COG0840	transmembrane signaling receptor activity
At12D13_01750	COG2205	protein histidine kinase activity
At12D13_01750	COG0784	Response regulator, receiver
At12D13_01750	COG2198	Histidine kinase
At12D13_01760	COG1970	mechanosensitive ion channel activity
At12D13_01770	COG0436	Aminotransferase
At12D13_01800	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
At12D13_01810	COG0424	maF-like protein
At12D13_01820	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
At12D13_01840	COG5328	Belongs to the UPF0262 family
At12D13_01850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
At12D13_01870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
At12D13_01890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
At12D13_01920	COG1338	Plays a role in the flagellum-specific transport system
At12D13_01940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
At12D13_01960	COG1706	bacterial-type flagellum-dependent cell motility
At12D13_01970	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
At12D13_01980	COG4786	Flagellar basal body rod
At12D13_01990	COG1677	Flagellar hook-basal body complex protein FliE
At12D13_02000	COG1558	bacterial-type flagellum-dependent cell motility
At12D13_02010	COG1815	bacterial-type flagellum-dependent cell motility
At12D13_02030	COG1157	protein secretion by the type III secretion system
At12D13_02040	COG4786	Flagellar basal body rod
At12D13_02060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
At12D13_02070	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_02080	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_02090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
At12D13_02100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D13_02140	COG1360	Flagellar Motor Protein
At12D13_02190	COG1749	Flagellar hook protein flgE
At12D13_02230	COG5443	negative regulation of bacterial-type flagellum assembly
At12D13_02240	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
At12D13_02260	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
At12D13_02340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
At12D13_02350	COG1609	Transcriptional regulator
At12D13_02360	COG1653	transport
At12D13_02370	COG1175	transmembrane transport
At12D13_02380	COG0395	ABC-type sugar transport system, permease component
At12D13_02390	COG0366	Alpha amylase catalytic
At12D13_02400	COG3842	ATPase activity
At12D13_02420	COG3609	addiction module antidote protein, CC2985 family
At12D13_02440	COG0129	dihydroxy-acid dehydratase activity
At12D13_02450	COG0363	glucosamine-6-phosphate deaminase activity
At12D13_02460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
At12D13_02470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_02490	COG2081	HI0933 family
At12D13_02530	COG2224	Isocitrate lyase
At12D13_02560	COG3842	ATPase activity
At12D13_02570	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_02580	COG1177	transmembrane transport
At12D13_02600	COG2205	protein histidine kinase activity
At12D13_02610	COG0248	Ppx GppA phosphatase
At12D13_02620	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
At12D13_02630	COG0477	Major facilitator Superfamily
At12D13_02720	COG0521	Mo-molybdopterin cofactor biosynthetic process
At12D13_02730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
At12D13_02750	COG0142	geranyltranstransferase activity
At12D13_02800	COG0752	glycyl-tRNA synthetase alpha subunit
At12D13_02820	COG1704	LemA family
At12D13_02830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
At12D13_02850	COG0751	glycine-tRNA ligase activity
At12D13_02860	COG1683	Conserved Protein
At12D13_02870	COG0840	transmembrane signaling receptor activity
At12D13_02890	COG0151	Belongs to the GarS family
At12D13_02900	COG2183	response to ionizing radiation
At12D13_02910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_02930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
At12D13_02960	COG0583	DNA-binding transcription factor activity
At12D13_03000	COG0306	phosphate transporter
At12D13_03020	COG0561	phosphatase activity
At12D13_03030	COG0438	transferase activity, transferring glycosyl groups
At12D13_03040	COG2186	Transcriptional regulator
At12D13_03060	COG0583	DNA-binding transcription factor activity
At12D13_03070	COG0277	FAD linked oxidase domain protein
At12D13_03080	COG0277	FAD linked oxidase domain protein
At12D13_03090	COG0247	lactate metabolic process
At12D13_03110	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_03120	COG0519	Catalyzes the synthesis of GMP from XMP
At12D13_03140	COG2855	membrane
At12D13_03150	COG0583	DNA-binding transcription factor activity
At12D13_03190	COG0124	histidyl-tRNA synthetase
At12D13_03200	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
At12D13_03210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
At12D13_03220	COG2259	Doxx family
At12D13_03240	COG0459	protein refolding
At12D13_03250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
At12D13_03270	COG0196	riboflavin kinase activity
At12D13_03280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
At12D13_03300	COG0590	tRNA wobble adenosine to inosine editing
At12D13_03310	COG1187	pseudouridine synthase activity
At12D13_03320	COG0742	ribosomal rna small subunit methyltransferase
At12D13_03330	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D13_03340	COG0475	glutathione-regulated potassium exporter activity
At12D13_03340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
At12D13_03350	COG0312	modulator of DNA gyrase
At12D13_03360	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_03380	COG1519	Transferase
At12D13_03400	COG1663	tetraacyldisaccharide 4'-kinase activity
At12D13_03420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
At12D13_03440	COG5001	Diguanylate cyclase
At12D13_03440	COG3300	MHYT domain
At12D13_03450	COG3386	PFAM SMP-30 Gluconolaconase
At12D13_03460	COG0800	Aldolase
At12D13_03470	COG3734	2-keto-3-deoxy-galactonokinase
At12D13_03480	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_03500	COG2197	response regulator
At12D13_03510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_03530	COG0598	Magnesium transport protein CorA
At12D13_03540	COG3158	transport of potassium into the cell
At12D13_03570	COG0356	it plays a direct role in the translocation of protons across the membrane
At12D13_03590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D13_03600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
At12D13_03630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
At12D13_03670	COG0009	L-threonylcarbamoyladenylate synthase
At12D13_03690	COG4638	Rieske (2fe-2S)
At12D13_03740	COG1960	acyl-CoA dehydrogenase activity
At12D13_03770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
At12D13_03780	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
At12D13_03790	COG0840	transmembrane signaling receptor activity
At12D13_03810	COG1522	sequence-specific DNA binding
At12D13_03870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
At12D13_03880	COG1741	Belongs to the pirin family
At12D13_03890	COG1722	exodeoxyribonuclease VII activity
At12D13_03900	COG0123	including yeast histone deacetylase and acetoin utilization protein
At12D13_03910	COG1268	BioY protein
At12D13_03920	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
At12D13_03930	COG1122	ATPase activity
At12D13_03940	COG3214	Protein conserved in bacteria
At12D13_03960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
At12D13_03990	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D13_04020	COG0259	pyridoxamine-phosphate oxidase activity
At12D13_04050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_04070	COG0312	modulator of DNA gyrase
At12D13_04100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_04110	COG0109	protoheme IX farnesyltransferase activity
At12D13_04130	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
At12D13_04160	COG3346	SURF1 family
At12D13_04170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
At12D13_04180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
At12D13_04190	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_04220	COG0678	peroxiredoxin activity
At12D13_04220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
At12D13_04240	COG1678	Uncharacterized ACR, COG1678
At12D13_04280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
At12D13_04290	COG0612	Peptidase, M16
At12D13_04320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_04330	COG1802	Transcriptional regulator
At12D13_04360	COG2189	Belongs to the N(4) N(6)-methyltransferase family
At12D13_04370	COG3609	addiction module antidote protein, CC2985 family
At12D13_04400	COG1194	a g-specific adenine glycosylase
At12D13_04420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
At12D13_04430	COG1196	nuclear chromosome segregation
At12D13_04450	COG2514	catechol 2,3-dioxygenase activity
At12D13_04460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
At12D13_04460	COG0574	Belongs to the PEP-utilizing enzyme family
At12D13_04540	COG0579	oxidoreductase
At12D13_04560	COG2895	sulfate adenylyltransferase (ATP) activity
At12D13_04570	COG0175	sulfate reduction
At12D13_04580	COG0175	sulfate reduction
At12D13_04590	COG1959	2 iron, 2 sulfur cluster binding
At12D13_04600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
At12D13_04610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
At12D13_04620	COG4208	sulfate ABC transporter
At12D13_04630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D13_04650	COG2200	EAL domain
At12D13_04650	COG2203	Gaf domain
At12D13_04650	COG2199	diguanylate cyclase activity
At12D13_04670	COG1309	transcriptional regulator
At12D13_04680	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_04690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
At12D13_04780	COG0477	Major facilitator Superfamily
At12D13_04800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
At12D13_04800	COG1793	dna ligase
At12D13_04840	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_04850	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_04860	COG1846	Transcriptional regulator
At12D13_04870	COG1764	response to oxidative stress
At12D13_04900	COG0488	(ABC) transporter
At12D13_04970	COG4221	oxidoreductase activity
At12D13_05000	COG0433	COG0433 Predicted ATPase
At12D13_05020	COG1733	regulation of RNA biosynthetic process
At12D13_05030	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
At12D13_05060	COG0656	L-ascorbic acid biosynthetic process
At12D13_05070	COG3781	membrane
At12D13_05080	COG2378	regulation of single-species biofilm formation
At12D13_05100	COG4106	trans-aconitate 2-methyltransferase activity
At12D13_05110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_05120	COG0840	transmembrane signaling receptor activity
At12D13_05130	COG0583	DNA-binding transcription factor activity
At12D13_05160	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D13_05180	COG2378	regulation of single-species biofilm formation
At12D13_05200	COG3909	cytochrome
At12D13_05210	COG2010	Cytochrome c
At12D13_05270	COG0789	Transcriptional regulator
At12D13_05320	COG0517	IMP dehydrogenase activity
At12D13_05320	COG4175	Glycine betaine
At12D13_05330	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_05370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_05390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_05390	COG2169	Transcriptional regulator
At12D13_05410	COG2514	catechol 2,3-dioxygenase activity
At12D13_05440	COG1272	protein, Hemolysin III
At12D13_05460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D13_05480	COG2111	Na H antiporter
At12D13_05490	COG1006	Multisubunit Na H antiporter MnhC subunit
At12D13_05510	COG1863	multisubunit Na H antiporter MnhE subunit
At12D13_05520	COG2212	antiporter activity
At12D13_05530	COG1320	monovalent cation:proton antiporter activity
At12D13_05540	COG4957	zinc ion binding
At12D13_05570	COG2166	iron-sulfur cluster assembly
At12D13_05590	COG2205	protein histidine kinase activity
At12D13_05710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_05720	COG2983	Belongs to the UPF0260 family
At12D13_05790	COG2337	Toxic component of a toxin-antitoxin (TA) module
At12D13_05830	COG1621	beta-fructofuranosidase activity
At12D13_05840	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
At12D13_05950	COG4695	Portal protein
At12D13_06120	COG0745	RESPONSE REGULATOR receiver
At12D13_06130	COG3852	Histidine kinase
At12D13_06150	COG4235	cytochrome complex assembly
At12D13_06160	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
At12D13_06170	COG1138	Cytochrome C-type biogenesis protein
At12D13_06180	COG3088	subunit of a heme lyase
At12D13_06190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D13_06220	COG3713	MltA-interacting MipA family protein
At12D13_06230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
At12D13_06240	COG2205	protein histidine kinase activity
At12D13_06240	COG2202	Pas domain
At12D13_06260	COG0308	aminopeptidase N
At12D13_06270	COG0697	spore germination
At12D13_06300	COG0443	Heat shock 70 kDa protein
At12D13_06320	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_06380	COG0604	alcohol dehydrogenase
At12D13_06390	COG1733	regulation of RNA biosynthetic process
At12D13_06400	COG1968	undecaprenyl-diphosphatase activity
At12D13_06410	COG2239	Acts as a magnesium transporter
At12D13_06420	COG2814	Major facilitator Superfamily
At12D13_06480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
At12D13_06540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D13_06630	COG0741	lytic transglycosylase activity
At12D13_06640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_06650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
At12D13_06660	COG0840	transmembrane signaling receptor activity
At12D13_06680	COG1758	RNA polymerase activity
At12D13_06720	COG0736	holo-[acyl-carrier-protein] synthase activity
At12D13_06730	COG0681	Belongs to the peptidase S26 family
At12D13_06740	COG0571	ribonuclease III activity
At12D13_06750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
At12D13_06760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D13_06770	COG0784	Response regulator, receiver
At12D13_06780	COG1381	Involved in DNA repair and RecF pathway recombination
At12D13_06800	COG2226	methyltransferase
At12D13_06820	COG1418	mRNA catabolic process
At12D13_06840	COG0346	lactoylglutathione lyase activity
At12D13_06870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_06880	COG3443	Belongs to the bacterial solute-binding protein 9 family
At12D13_06890	COG0668	transmembrane transport
At12D13_06910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
At12D13_06960	COG1051	belongs to the nudix hydrolase family
At12D13_06970	COG1742	UPF0060 membrane protein
At12D13_06990	COG0745	RESPONSE REGULATOR receiver
At12D13_06990	COG3706	GGDEF domain
At12D13_07010	COG1183	phosphatidylcholine synthase activity
At12D13_07020	COG0688	phosphatidylethanolamine metabolic process
At12D13_07030	COG5265	(ABC) transporter
At12D13_07040	COG1652	LysM domain
At12D13_07110	COG2852	Protein conserved in bacteria
At12D13_07120	COG0215	cysteine-tRNA ligase activity
At12D13_07130	COG4221	oxidoreductase activity
At12D13_07140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
At12D13_07150	COG1286	toxin biosynthetic process
At12D13_07190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D13_07210	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
At12D13_07230	COG5265	(ABC) transporter
At12D13_07240	COG0305	Participates in initiation and elongation during chromosome replication
At12D13_07280	COG0359	binds to the 23S rRNA
At12D13_07300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
At12D13_07310	COG0360	Binds together with S18 to 16S ribosomal RNA
At12D13_07320	COG0667	Aldo Keto reductase
At12D13_07330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
At12D13_07350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_07360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_07370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
At12D13_07380	COG1561	YicC-like family, N-terminal region
At12D13_07390	COG0194	GDP metabolic process
At12D13_07410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D13_07420	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_07440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
At12D13_07470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D13_07510	COG5001	Diguanylate cyclase
At12D13_07510	COG3300	MHYT domain
At12D13_07520	COG4191	Histidine kinase
At12D13_07550	COG0488	(ABC) transporter
At12D13_07560	COG3706	GGDEF domain
At12D13_07580	COG0105	UTP biosynthetic process
At12D13_07620	COG0314	molybdopterin synthase activity
At12D13_07630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
At12D13_07640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
At12D13_07650	COG0322	excinuclease ABC activity
At12D13_07660	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_07680	COG0625	glutathione transferase activity
At12D13_07710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
At12D13_07720	COG0243	molybdopterin cofactor binding
At12D13_07750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
At12D13_07760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
At12D13_07770	COG0628	permease
At12D13_07790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
At12D13_07800	COG0248	Ppx GppA phosphatase
At12D13_07850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
At12D13_07870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
At12D13_07880	COG0477	Major facilitator Superfamily
At12D13_07890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
At12D13_07910	COG4452	Inner membrane protein CreD
At12D13_07920	COG0659	secondary active sulfate transmembrane transporter activity
At12D13_07940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D13_07950	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
At12D13_07970	COG0113	porphobilinogen synthase activity
At12D13_08010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D13_08020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
At12D13_08030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D13_08030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
At12D13_08050	COG1280	lysine exporter protein (LysE YggA)
At12D13_08060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
At12D13_08070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D13_08080	COG2814	Major facilitator Superfamily
At12D13_08090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
At12D13_08130	COG0416	fatty acid biosynthetic process
At12D13_08140	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D13_08150	COG0776	regulation of translation
At12D13_08210	COG0601	transmembrane transport
At12D13_08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_08230	COG0444	Belongs to the ABC transporter superfamily
At12D13_08270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
At12D13_08280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
At12D13_08300	COG0745	RESPONSE REGULATOR receiver
At12D13_08300	COG3706	GGDEF domain
At12D13_08310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D13_08320	COG0583	DNA-binding transcription factor activity
At12D13_08330	COG0737	Belongs to the 5'-nucleotidase family
At12D13_08380	COG2897	thiosulfate sulfurtransferase activity
At12D13_08410	COG0415	Belongs to the DNA photolyase family
At12D13_08430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_08630	COG3932	Exopolysaccharide synthesis, ExoD
At12D13_08790	COG1612	heme a metabolic process
At12D13_08810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
At12D13_08820	COG0010	Belongs to the arginase family
At12D13_08830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
At12D13_08840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
At12D13_08860	COG1832	CoA-binding protein
At12D13_08910	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_08920	COG2124	cytochrome p450
At12D13_08930	COG2199	diguanylate cyclase activity
At12D13_08940	COG0740	serine-type endopeptidase activity
At12D13_08950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
At12D13_08960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
At12D13_08980	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_09000	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_09010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_09020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_09040	COG0649	NAD binding
At12D13_09060	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
At12D13_09070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
At12D13_09090	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
At12D13_09100	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
At12D13_09120	COG0713	ATP synthesis coupled electron transport
At12D13_09150	COG1007	ATP synthesis coupled electron transport
At12D13_09190	COG0442	prolyl-tRNA aminoacylation
At12D13_09210	COG1136	(ABC) transporter
At12D13_09220	COG0587	DNA-directed DNA polymerase activity
At12D13_09240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_09260	COG0784	Response regulator, receiver
At12D13_09270	COG0745	RESPONSE REGULATOR receiver
At12D13_09270	COG3706	GGDEF domain
At12D13_09280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
At12D13_09290	COG0477	Major facilitator Superfamily
At12D13_09320	COG0557	exoribonuclease II activity
At12D13_09330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
At12D13_09350	COG0758	DNA mediated transformation
At12D13_09360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
At12D13_09380	COG0540	Belongs to the ATCase OTCase family
At12D13_09400	COG1960	acyl-CoA dehydrogenase activity
At12D13_09410	COG0456	acetyltransferase
At12D13_09470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
At12D13_09480	COG2824	Alkylphosphonate utilization operon protein PhnA
At12D13_09490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
At12D13_09500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D13_09510	COG0154	amidase activity
At12D13_09520	COG0456	acetyltransferase
At12D13_09530	COG3811	Belongs to the UPF0386 family
At12D13_09560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
At12D13_09580	COG0456	acetyltransferase
At12D13_09610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
At12D13_09620	COG0439	Biotin carboxylase
At12D13_09630	COG0511	ligase activity, forming carbon-carbon bonds
At12D13_09640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D13_09660	COG0436	Aminotransferase
At12D13_09700	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_09710	COG1530	ribonuclease E activity
At12D13_09730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_09770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
At12D13_09780	COG0384	phenazine biosynthesis protein PhzF
At12D13_09810	COG0633	Ferredoxin
At12D13_09830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
At12D13_09840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
At12D13_09850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
At12D13_09870	COG3768	UPF0283 membrane protein
At12D13_09880	COG3106	COG3106 Predicted ATPase
At12D13_09900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
At12D13_09940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D13_10000	COG0537	adenosine 5'-monophosphoramidase activity
At12D13_10050	COG0052	Belongs to the universal ribosomal protein uS2 family
At12D13_10060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
At12D13_10070	COG0528	UMP kinase activity
At12D13_10080	COG0233	cytoplasmic translational termination
At12D13_10090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
At12D13_10100	COG0575	Belongs to the CDS family
At12D13_10110	COG0750	zinc metalloprotease
At12D13_10120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D13_10130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_10140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_10150	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_10160	COG3494	Protein of unknown function (DUF1009)
At12D13_10170	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
At12D13_10180	COG2186	Transcriptional regulator
At12D13_10200	COG0765	amino acid transport
At12D13_10210	COG0765	amino acid transport
At12D13_10230	COG0372	Belongs to the citrate synthase family
At12D13_10260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
At12D13_10270	COG4598	ABC transporter
At12D13_10280	COG0765	amino acid transport
At12D13_10290	COG0765	amino acid transport
At12D13_10300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_10310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_10320	COG3842	ATPase activity
At12D13_10330	COG0395	ABC-type sugar transport system, permease component
At12D13_10350	COG2182	Extracellular solute-binding protein
At12D13_10370	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_10380	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_10390	COG1063	alcohol dehydrogenase
At12D13_10400	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
At12D13_10410	COG0410	ABC transporter
At12D13_10420	COG0411	ABC transporter
At12D13_10440	COG0683	leucine binding
At12D13_10450	COG1960	acyl-CoA dehydrogenase activity
At12D13_10480	COG1024	Enoyl-CoA hydratase
At12D13_10510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_10550	COG2877	3-deoxy-8-phosphooctulonate synthase activity
At12D13_10560	COG0148	phosphopyruvate hydratase activity
At12D13_10580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
At12D13_10590	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_10590	COG0022	dehydrogenase e1 component
At12D13_10610	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_10630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
At12D13_10650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
At12D13_10660	COG0697	spore germination
At12D13_10700	COG2867	negative regulation of translational initiation
At12D13_10710	COG1546	Belongs to the CinA family
At12D13_10720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
At12D13_10720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
At12D13_10740	COG3852	Histidine kinase
At12D13_10750	COG2204	response regulator
At12D13_10760	COG5000	phosphorelay sensor kinase activity
At12D13_10770	COG2204	response regulator
At12D13_10780	COG0569	domain protein
At12D13_10790	COG1923	regulation of RNA biosynthetic process
At12D13_10800	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
At12D13_10810	COG3956	TIGRFAM MazG family protein
At12D13_10830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_10830	COG1648	precorrin-2 dehydrogenase activity
At12D13_10860	COG0275	rRNA processing
At12D13_10910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D13_10910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
At12D13_10920	COG0509	glycine decarboxylation via glycine cleavage system
At12D13_10930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_10980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
At12D13_10990	COG0564	pseudouridine synthase activity
At12D13_11030	COG0251	oxidation-reduction process
At12D13_11040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
At12D13_11060	COG1671	Belongs to the UPF0178 family
At12D13_11080	COG0450	alkyl hydroperoxide reductase
At12D13_11170	COG0431	NADPH-dependent FMN reductase
At12D13_11180	COG0798	PFAM Bile acid sodium symporter
At12D13_11220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
At12D13_11220	COG0321	lipoyl(octanoyl) transferase activity
At12D13_11230	COG0084	hydrolase, TatD family'
At12D13_11240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_11260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
At12D13_11360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
At12D13_11370	COG2095	MarC family integral membrane protein
At12D13_11400	COG3609	addiction module antidote protein, CC2985 family
At12D13_11410	COG0629	single-stranded DNA binding
At12D13_11420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
At12D13_11440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
At12D13_11450	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_11480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_11490	COG1121	(ABC) transporter
At12D13_11500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
At12D13_11530	COG0667	Aldo Keto reductase
At12D13_11550	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
At12D13_11690	COG0668	transmembrane transport
At12D13_11740	COG2239	Acts as a magnesium transporter
At12D13_11750	COG0243	molybdopterin cofactor binding
At12D13_11770	COG0242	peptide deformylase activity
At12D13_11820	COG0321	lipoyl(octanoyl) transferase activity
At12D13_11830	COG1064	alcohol dehydrogenase
At12D13_11930	COG1309	transcriptional regulator
At12D13_11940	COG2124	cytochrome p450
At12D13_11990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_12000	COG0626	cystathionine gamma-synthase activity
At12D13_12010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_12020	COG4597	amino acid ABC transporter
At12D13_12030	COG0765	amino acid transport
At12D13_12040	COG1126	abc transporter atp-binding protein
At12D13_12050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
At12D13_12080	COG0436	Aminotransferase
At12D13_12140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_12160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_12170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_12180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
At12D13_12210	COG3243	poly(R)-hydroxyalkanoic acid synthase
At12D13_12220	COG1489	DNA binding
At12D13_12230	COG0024	Methionine aminopeptidase
At12D13_12240	COG2003	Belongs to the UPF0758 family
At12D13_12270	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
At12D13_12300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
At12D13_12310	COG0546	phosphoglycolate phosphatase activity
At12D13_12330	COG0114	fumarate hydratase activity
At12D13_12340	COG2755	lipolytic protein G-D-S-L family
At12D13_12340	COG0657	acetylesterase activity
At12D13_12350	COG0504	CTP synthase activity
At12D13_12370	COG0149	triose-phosphate isomerase activity
At12D13_12390	COG0187	DNA topoisomerase II activity
At12D13_12410	COG1309	transcriptional regulator
At12D13_12420	COG2226	methyltransferase
At12D13_12430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_12440	COG0740	serine-type endopeptidase activity
At12D13_12460	COG0640	Transcriptional regulator
At12D13_12470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D13_12500	COG3264	Mechanosensitive ion channel
At12D13_12500	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
At12D13_12620	COG1127	ABC transporter
At12D13_12630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
At12D13_12640	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_12670	COG0280	phosphate acetyltransferase
At12D13_12670	COG0281	malic enzyme
At12D13_12690	COG0778	Nitroreductase
At12D13_12700	COG0823	Involved in the tonB-independent uptake of proteins
At12D13_12720	COG1368	sulfuric ester hydrolase activity
At12D13_12770	COG0544	peptidyl-prolyl cis-trans isomerase activity
At12D13_12800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
At12D13_12810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
At12D13_12840	COG0318	PFAM AMP-dependent synthetase and ligase
At12D13_12870	COG0343	queuine tRNA-ribosyltransferase activity
At12D13_12880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
At12D13_12890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
At12D13_12900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
At12D13_12910	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
At12D13_12950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D13_12960	COG0134	indole-3-glycerol-phosphate synthase activity
At12D13_12970	COG0315	cyclic pyranopterin monophosphate synthase activity
At12D13_12980	COG0303	'Molybdopterin
At12D13_12990	COG3706	GGDEF domain
At12D13_13010	COG0475	glutathione-regulated potassium exporter activity
At12D13_13010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
At12D13_13030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
At12D13_13040	COG0697	spore germination
At12D13_13050	COG2814	Major facilitator Superfamily
At12D13_13060	COG0746	molybdenum cofactor guanylyltransferase activity
At12D13_13070	COG1763	Mo-molybdopterin cofactor biosynthetic process
At12D13_13080	COG0739	heme binding
At12D13_13090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D13_13100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
At12D13_13110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D13_13120	COG0805	protein transport
At12D13_13130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D13_13140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
At12D13_13150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
At12D13_13160	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
At12D13_13170	COG1472	Belongs to the glycosyl hydrolase 3 family
At12D13_13190	COG0018	arginyl-trna synthetase
At12D13_13200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
At12D13_13210	COG0316	Belongs to the HesB IscA family
At12D13_13230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
At12D13_13250	COG0525	valine-tRNA ligase activity
At12D13_13270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
At12D13_13350	COG0655	NAD(P)H dehydrogenase (quinone) activity
At12D13_13360	COG1546	Belongs to the CinA family
At12D13_13360	COG1058	Belongs to the CinA family
At12D13_13370	COG0589	response to stress
At12D13_13380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
At12D13_13390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
At12D13_13420	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D13_13440	COG1132	(ABC) transporter
At12D13_13450	COG0628	permease
At12D13_13490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_13520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
At12D13_13540	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
At12D13_13560	COG0302	gtp cyclohydrolase
At12D13_13570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
At12D13_13580	COG1752	Esterase of the alpha-beta hydrolase superfamily
At12D13_13590	COG0516	GMP reductase activity
At12D13_13590	COG0517	IMP dehydrogenase activity
At12D13_13650	COG1760	l-serine dehydratase
At12D13_13720	COG0583	DNA-binding transcription factor activity
At12D13_13750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
At12D13_13750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
At12D13_13760	COG0347	Belongs to the P(II) protein family
At12D13_13770	COG0174	glutamine synthetase
At12D13_13830	COG0697	spore germination
At12D13_13850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
At12D13_13870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
At12D13_13890	COG3668	Plasmid stabilization system
At12D13_13900	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
At12D13_13930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
At12D13_13940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D13_13950	COG2186	Transcriptional regulator
At12D13_13990	COG1129	ABC transporter
At12D13_14000	COG1183	phosphatidylcholine synthase activity
At12D13_14010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_14020	COG0679	Auxin Efflux Carrier
At12D13_14030	COG0785	Cytochrome C biogenesis protein
At12D13_14090	COG1278	Cold shock
At12D13_14170	COG2267	carboxylic ester hydrolase activity
At12D13_14200	COG1136	(ABC) transporter
At12D13_14200	COG0577	efflux transmembrane transporter activity
At12D13_14210	COG0577	efflux transmembrane transporter activity
At12D13_14210	COG1136	(ABC) transporter
At12D13_14240	COG2151	metal-sulfur cluster biosynthetic enzyme
At12D13_14250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
At12D13_14260	COG0719	Fe-S assembly protein
At12D13_14270	COG0396	ATPase activity
At12D13_14290	COG0719	Fe-S assembly protein
At12D13_14300	COG1104	cysteine desulfurase activity
At12D13_14310	COG2945	thiolester hydrolase activity
At12D13_14320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
At12D13_14330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
At12D13_14350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
At12D13_14360	COG2833	Protein of unknown function (DUF455)
At12D13_14370	COG0739	heme binding
At12D13_14380	COG0513	Belongs to the DEAD box helicase family
At12D13_14440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
At12D13_14460	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D13_14470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D13_14480	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D13_14510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_14530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
At12D13_14570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
At12D13_14580	COG2814	Major facilitator Superfamily
At12D13_14590	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_14600	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_14610	COG0037	tRNA processing
At12D13_14620	COG2066	Belongs to the glutaminase family
At12D13_14630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
At12D13_14640	COG0861	Integral membrane protein TerC family
At12D13_14670	COG1280	lysine exporter protein (LysE YggA)
At12D13_14700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
At12D13_14710	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
At12D13_14730	COG0538	isocitrate dehydrogenase activity
At12D13_14780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
At12D13_14790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
At12D13_14800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_14810	COG2313	pseudouridylate synthase activity
At12D13_14830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_14840	COG4215	(ABC) transporter
At12D13_14860	COG5425	PFAM Usg family protein
At12D13_14880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_14890	COG1522	sequence-specific DNA binding
At12D13_14900	COG1573	uracil-dna glycosylase
At12D13_14920	COG2202	Pas domain
At12D13_14920	COG2205	protein histidine kinase activity
At12D13_14940	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
At12D13_14950	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
At12D13_14980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
At12D13_14990	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_15000	COG1129	ABC transporter
At12D13_15010	COG1879	ABC-type sugar transport system periplasmic component
At12D13_15020	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_15030	COG3959	Transketolase, thiamine diphosphate binding domain
At12D13_15040	COG3958	Transketolase
At12D13_15050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D13_15060	COG2390	Transcriptional regulator
At12D13_15080	COG0842	Transport permease protein
At12D13_15090	COG1131	(ABC) transporter
At12D13_15100	COG0730	response to heat
At12D13_15120	COG0840	transmembrane signaling receptor activity
At12D13_15120	COG0840	transmembrane signaling receptor activity
At12D13_15140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
At12D13_15150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
At12D13_15180	COG0129	dihydroxy-acid dehydratase activity
At12D13_15190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
At12D13_15200	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
At12D13_15220	COG3739	integral membrane protein
At12D13_15230	COG0203	ribosomal protein L17
At12D13_15240	COG0202	RNA polymerase activity
At12D13_15250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
At12D13_15260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
At12D13_15270	COG0563	adenylate kinase activity
At12D13_15280	COG0201	protein transport
At12D13_15290	COG0200	Binds to the 23S rRNA
At12D13_15300	COG1841	ribosomal large subunit assembly
At12D13_15310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
At12D13_15320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
At12D13_15330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
At12D13_15340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
At12D13_15350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
At12D13_15360	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
At12D13_15370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
At12D13_15380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
At12D13_15390	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
At12D13_15400	COG0255	Belongs to the universal ribosomal protein uL29 family
At12D13_15410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
At12D13_15420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
At12D13_15430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
At12D13_15440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
At12D13_15450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
At12D13_15460	COG0089	rRNA binding
At12D13_15470	COG0088	Forms part of the polypeptide exit tunnel
At12D13_15480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
At12D13_15490	COG0051	transcription antitermination factor activity, RNA binding
At12D13_15500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D13_15510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
At12D13_15520	COG0049	tRNA binding
At12D13_15530	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
At12D13_15570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
At12D13_15580	COG0085	RNA polymerase activity
At12D13_15590	COG0222	ribosome binding
At12D13_15600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
At12D13_15610	COG0081	regulation of translation
At12D13_15620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
At12D13_15650	COG1086	Polysaccharide biosynthesis protein
At12D13_15660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
At12D13_15670	COG0861	Integral membrane protein TerC family
At12D13_15690	COG3895	Periplasmic Protein
At12D13_15730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_15770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
At12D13_15840	COG0784	Response regulator, receiver
At12D13_15840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_15840	COG2198	Histidine kinase
At12D13_15840	COG2205	protein histidine kinase activity
At12D13_15850	COG0784	Response regulator, receiver
At12D13_15860	COG3920	Histidine kinase
At12D13_15860	COG2202	Pas domain
At12D13_15870	COG0784	Response regulator, receiver
At12D13_15880	COG4251	negative regulation of phosphorylation
At12D13_15890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
At12D13_15900	COG1607	acyl-coa hydrolase
At12D13_15950	COG2910	NAD(P)H-binding
At12D13_15960	COG1733	regulation of RNA biosynthetic process
At12D13_15970	COG0556	nucleotide-excision repair
At12D13_16020	COG0484	heat shock protein binding
At12D13_16040	COG3706	GGDEF domain
At12D13_16060	COG3842	ATPase activity
At12D13_16080	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_16090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_16100	COG4154	Belongs to the RbsD FucU family
At12D13_16110	COG4115	mRNA cleavage
At12D13_16130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
At12D13_16150	COG2207	Transcriptional regulator
At12D13_16160	COG1064	alcohol dehydrogenase
At12D13_16170	COG1252	NADH dehydrogenase
At12D13_16180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
At12D13_16190	COG2197	response regulator
At12D13_16200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
At12D13_16260	COG0656	L-ascorbic acid biosynthetic process
At12D13_16290	COG0440	acetolactate synthase activity
At12D13_16300	COG0028	Belongs to the TPP enzyme family
At12D13_16320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
At12D13_16330	COG3830	Belongs to the UPF0237 family
At12D13_16330	COG0560	Phosphoserine phosphatase
At12D13_16380	COG0330	HflC and HflK could
At12D13_16390	COG0330	HflC and HflK could
At12D13_16410	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
At12D13_16470	COG0277	FAD linked oxidase domain protein
At12D13_16480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_16590	COG1335	isochorismatase
At12D13_16630	COG0006	proline dipeptidase activity
At12D13_16660	COG2264	protein methyltransferase activity
At12D13_16670	COG1999	signal sequence binding
At12D13_16680	COG0835	chemotaxis
At12D13_16700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
At12D13_16710	COG0583	DNA-binding transcription factor activity
At12D13_16730	COG1247	-acetyltransferase
At12D13_16750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
At12D13_16760	COG0497	DNA recombination
At12D13_16770	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
At12D13_16790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D13_16800	COG0849	cell division
At12D13_16810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
At12D13_16820	COG1181	Belongs to the D-alanine--D-alanine ligase family
At12D13_16830	COG0477	Major facilitator Superfamily
At12D13_16840	COG5001	Diguanylate cyclase
At12D13_16840	COG3300	MHYT domain
At12D13_16850	COG0812	UDP-N-acetylmuramate dehydrogenase activity
At12D13_16860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
At12D13_16870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D13_16890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
At12D13_16900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
At12D13_16920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
At12D13_16950	COG0275	rRNA processing
At12D13_16960	COG2001	Belongs to the MraZ family
At12D13_16970	COG3766	membrane
At12D13_16990	COG0754	glutathionylspermidine amidase activity
At12D13_17030	COG3023	N-Acetylmuramoyl-L-alanine amidase
At12D13_17040	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
At12D13_17090	COG4106	trans-aconitate 2-methyltransferase activity
At12D13_17150	COG2267	carboxylic ester hydrolase activity
At12D13_17160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
At12D13_17190	COG0251	oxidation-reduction process
At12D13_17220	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_17230	COG2814	Major facilitator Superfamily
At12D13_17280	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_17310	COG0174	glutamine synthetase
At12D13_17320	COG0531	amino acid
At12D13_17340	COG1737	Transcriptional regulator
At12D13_17380	COG3842	ATPase activity
At12D13_17680	COG2968	Membrane
At12D13_17700	COG0432	Pfam Uncharacterised protein family UPF0047
At12D13_17730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D13_17740	COG0358	DNA primase activity
At12D13_17760	COG0505	Belongs to the CarA family
At12D13_17770	COG0534	Mate efflux family protein
At12D13_17800	COG2321	neutral zinc metallopeptidase
At12D13_17830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
At12D13_17850	COG3706	GGDEF domain
At12D13_17880	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D13_17900	COG1522	sequence-specific DNA binding
At12D13_17910	COG0492	ferredoxin-NADP+ reductase activity
At12D13_17920	COG0583	DNA-binding transcription factor activity
At12D13_17940	COG1902	pentaerythritol trinitrate reductase activity
At12D13_17990	COG0387	Pfam Sodium calcium exchanger
At12D13_18010	COG2199	diguanylate cyclase activity
At12D13_18010	COG2200	EAL domain
At12D13_18040	COG1278	Cold shock
At12D13_18050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_18070	COG1846	Transcriptional regulator
At12D13_18080	COG0745	RESPONSE REGULATOR receiver
At12D13_18090	COG2205	protein histidine kinase activity
At12D13_18100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_18140	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
At12D13_18190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
At12D13_18210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
At12D13_18240	COG0840	transmembrane signaling receptor activity
At12D13_18250	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_18270	COG3300	MHYT domain
At12D13_18270	COG5001	Diguanylate cyclase
At12D13_18290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
At12D13_18300	COG5001	Diguanylate cyclase
At12D13_18320	COG0193	aminoacyl-tRNA hydrolase activity
At12D13_18340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
At12D13_18380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
At12D13_18400	COG2857	Cytochrome c1
At12D13_18400	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
At12D13_18440	COG1132	(ABC) transporter
At12D13_18450	COG1132	(ABC) transporter
At12D13_18460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
At12D13_18470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
At12D13_18500	COG0408	coproporphyrinogen oxidase activity
At12D13_18530	COG0617	tRNA 3'-terminal CCA addition
At12D13_18540	COG0494	nUDIX hydrolase
At12D13_18560	COG0714	Associated with various cellular activities
At12D13_18600	COG0454	-acetyltransferase
At12D13_18610	COG0477	Major facilitator Superfamily
At12D13_18630	COG0435	Glutathione S-transferase
At12D13_18660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
At12D13_18670	COG3135	benzoate transporter
At12D13_18700	COG1595	DNA-templated transcription, initiation
At12D13_18720	COG0740	serine-type endopeptidase activity
At12D13_18750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
At12D13_18760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
At12D13_18810	COG4175	Glycine betaine
At12D13_18840	COG1435	thymidine kinase activity
At12D13_18880	COG2862	Uncharacterized protein family, UPF0114
At12D13_18910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
At12D13_18910	COG0512	Glutamine amidotransferase of anthranilate synthase
At12D13_18940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D13_18970	COG0366	Alpha amylase catalytic
At12D13_18980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_19020	COG1160	GTP binding
At12D13_19060	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
At12D13_19080	COG0024	Methionine aminopeptidase
At12D13_19100	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_19120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_19150	COG0583	DNA-binding transcription factor activity
At12D13_19180	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_19210	COG1304	FMN binding
At12D13_19230	COG1309	transcriptional regulator
At12D13_19240	COG1686	Belongs to the peptidase S11 family
At12D13_19260	COG2351	hydroxyisourate hydrolase activity
At12D13_19270	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
At12D13_19320	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_19340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
At12D13_19340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_19360	COG0513	Belongs to the DEAD box helicase family
At12D13_19370	COG0697	spore germination
At12D13_19380	COG2259	Doxx family
At12D13_19390	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_19410	COG2308	Evidence 4 Homologs of previously reported genes of
At12D13_19430	COG1305	Transglutaminase-like
At12D13_19440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_19460	COG0456	acetyltransferase
At12D13_19490	COG4214	carbohydrate transport
At12D13_19500	COG1129	ABC transporter
At12D13_19510	COG4213	ABC transporter substrate-binding protein
At12D13_19570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_19590	COG0840	transmembrane signaling receptor activity
At12D13_19600	COG2814	Major facilitator Superfamily
At12D13_19610	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
At12D13_19610	COG0646	methionine synthase
At12D13_19630	COG4215	(ABC) transporter
At12D13_19640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_19690	COG1215	transferase activity, transferring glycosyl groups
At12D13_19750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D13_19760	COG2346	COG2346, Truncated hemoglobins
At12D13_19800	COG1309	transcriptional regulator
At12D13_19830	COG0494	nUDIX hydrolase
At12D13_19850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_19860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_19910	COG1234	tRNA 3'-trailer cleavage
At12D13_19920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
At12D13_19930	COG0830	nickel cation binding
At12D13_19940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
At12D13_19970	COG0804	urea catabolic process
At12D13_19980	COG1442	glycosyl transferase family 8
At12D13_19990	COG3755	Protein conserved in bacteria
At12D13_20010	COG0832	Belongs to the urease beta subunit family
At12D13_20020	COG3813	Protein conserved in bacteria
At12D13_20030	COG0831	urea catabolic process
At12D13_20040	COG0829	nickel cation binding
At12D13_20070	COG0411	ABC transporter
At12D13_20090	COG0559	Belongs to the binding-protein-dependent transport system permease family
At12D13_20120	COG0174	glutamine synthetase
At12D13_20130	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_20140	COG5002	protein histidine kinase activity
At12D13_20140	COG0784	Response regulator, receiver
At12D13_20140	COG2198	Histidine kinase
At12D13_20210	COG0411	ABC transporter
At12D13_20240	COG1218	3'(2'),5'-bisphosphate nucleotidase
At12D13_20400	COG0564	pseudouridine synthase activity
At12D13_20430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
At12D13_20450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
At12D13_20500	COG0346	lactoylglutathione lyase activity
At12D13_20520	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
At12D13_20540	COG2832	Protein of unknown function (DUF454)
At12D13_20550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
At12D13_20560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_20570	COG4558	Periplasmic binding protein
At12D13_20590	COG3721	Heme iron utilization protein
At12D13_20620	COG2205	protein histidine kinase activity
At12D13_20700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_20710	COG4605	iron ion homeostasis
At12D13_20720	COG4604	ABC transporter, ATP-binding protein
At12D13_20730	COG0783	Belongs to the Dps family
At12D13_20750	COG0583	DNA-binding transcription factor activity
At12D13_20770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_20810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
At12D13_20820	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
At12D13_20830	COG0288	reversible hydration of carbon dioxide
At12D13_20850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
At12D13_20880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
At12D13_20890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_20900	COG0778	Nitroreductase
At12D13_20910	COG2267	carboxylic ester hydrolase activity
At12D13_20920	COG0251	oxidation-reduction process
At12D13_20930	COG1335	isochorismatase
At12D13_20940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_20960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_20980	COG1653	transport
At12D13_20990	COG1175	transmembrane transport
At12D13_21000	COG0395	ABC-type sugar transport system, permease component
At12D13_21010	COG3842	ATPase activity
At12D13_21020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_21040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_21070	COG4608	Belongs to the ABC transporter superfamily
At12D13_21080	COG0444	Belongs to the ABC transporter superfamily
At12D13_21100	COG0601	transmembrane transport
At12D13_21140	COG0392	lysyltransferase activity
At12D13_21140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
At12D13_21220	COG2159	amidohydrolase
At12D13_21230	COG1960	acyl-CoA dehydrogenase activity
At12D13_21290	COG0745	RESPONSE REGULATOR receiver
At12D13_21310	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_21310	COG1902	pentaerythritol trinitrate reductase activity
At12D13_21350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
At12D13_21370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_21380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_21400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
At12D13_21420	COG1509	lysine 2,3-aminomutase activity
At12D13_21450	COG0583	DNA-binding transcription factor activity
At12D13_21460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_21470	COG0725	ABC transporter, periplasmic molybdate-binding protein
At12D13_21480	COG4149	molybdate abc transporter
At12D13_21490	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
At12D13_21510	COG3191	aminopeptidase activity
At12D13_21520	COG2022	thiamine diphosphate biosynthetic process
At12D13_21550	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
At12D13_21560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
At12D13_21580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
At12D13_21630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
At12D13_21680	COG0438	transferase activity, transferring glycosyl groups
At12D13_21720	COG4166	transmembrane transport
At12D13_21730	COG0601	transmembrane transport
At12D13_21740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_21760	COG0438	transferase activity, transferring glycosyl groups
At12D13_21770	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
At12D13_21780	COG3142	Participates in the control of copper homeostasis
At12D13_21820	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_21830	COG1737	Transcriptional regulator
At12D13_21850	COG3842	ATPase activity
At12D13_21870	COG0395	ABC-type sugar transport system, permease component
At12D13_21880	COG1175	transmembrane transport
At12D13_21920	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
At12D13_21930	COG1940	carbohydrate kinase activity
At12D13_21950	COG0671	phosphoesterase, PA-phosphatase related
At12D13_21960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
At12D13_21970	COG0156	8-amino-7-oxononanoate synthase activity
At12D13_21990	COG0729	surface antigen
At12D13_22010	COG0835	chemotaxis
At12D13_22030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
At12D13_22040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
At12D13_22050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
At12D13_22060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
At12D13_22070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
At12D13_22080	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
At12D13_22110	COG4974	Belongs to the 'phage' integrase family
At12D13_22160	COG1280	lysine exporter protein (LysE YggA)
At12D13_22180	COG0508	dehydrogenase complex catalyzes the overall conversion of
At12D13_22200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
At12D13_22210	COG0045	succinate-CoA ligase (ADP-forming) activity
At12D13_22220	COG0039	L-malate dehydrogenase activity
At12D13_22230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
At12D13_22300	COG2264	protein methyltransferase activity
At12D13_22330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
At12D13_22340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
At12D13_22350	COG0181	hydroxymethylbilane synthase activity
At12D13_22430	COG1872	DUF167
At12D13_22440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
At12D13_22480	COG0339	signal peptide processing
At12D13_22490	COG1846	Transcriptional regulator
At12D13_22500	COG2814	Major facilitator Superfamily
At12D13_22510	COG0137	argininosuccinate synthase activity
At12D13_22530	COG1280	lysine exporter protein (LysE YggA)
At12D13_22540	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
At12D13_22550	COG4120	Belongs to the binding-protein-dependent transport system permease family
At12D13_22570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
At12D13_22600	COG2154	pterin-4-alpha-carbinolamine dehydratase
At12D13_22610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
At12D13_22620	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
At12D13_22640	COG4181	ATPase activity
At12D13_22660	COG0670	Belongs to the BI1 family
At12D13_22690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
At12D13_22700	COG4133	protoheme IX ABC transporter activity
At12D13_22710	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D13_22720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
At12D13_22750	COG3706	GGDEF domain
At12D13_22770	COG2917	probably involved in intracellular septation
At12D13_22780	COG0552	protein localization to endoplasmic reticulum
At12D13_22790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
At12D13_22800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
At12D13_22820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
At12D13_22830	COG0287	Prephenate dehydrogenase
At12D13_22830	COG1605	Chorismate mutase
At12D13_22840	COG0228	four-way junction DNA binding
At12D13_22850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
At12D13_22860	COG0336	Belongs to the RNA methyltransferase TrmD family
At12D13_22880	COG0335	large ribosomal subunit rRNA binding
At12D13_22890	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D13_22900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_22930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
At12D13_22940	COG4783	chaperone-mediated protein folding
At12D13_22950	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
At12D13_23010	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
At12D13_23030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
At12D13_23040	COG0142	geranyltranstransferase activity
At12D13_23050	COG2885	chlorophyll binding
At12D13_23060	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
At12D13_23070	COG2223	nitrite transmembrane transporter activity
At12D13_23080	COG1349	DNA-binding transcription factor activity
At12D13_23090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
At12D13_23100	COG2197	response regulator
At12D13_23110	COG1132	(ABC) transporter
At12D13_23130	COG3459	Glycosyltransferase 36 associated
At12D13_23140	COG1473	amidohydrolase
At12D13_23160	COG0579	oxidoreductase
At12D13_23180	COG0129	dihydroxy-acid dehydratase activity
At12D13_23190	COG2084	Dehydrogenase
At12D13_23200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_23210	COG0277	FAD linked oxidase domain protein
At12D13_23220	COG2186	Transcriptional regulator
At12D13_23240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D13_23250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_23260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_23270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D13_23290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
At12D13_23300	COG0495	leucyl-tRNA aminoacylation
At12D13_23360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
At12D13_23370	COG1946	Acyl-CoA thioesterase
At12D13_23380	COG0347	Belongs to the P(II) protein family
At12D13_23390	COG0004	ammonium transporteR
At12D13_23400	COG1674	ftsk spoiiie
At12D13_23410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
At12D13_23440	COG0745	RESPONSE REGULATOR receiver
At12D13_23460	COG1329	Transcriptional regulator
At12D13_23470	COG2902	Dehydrogenase
At12D13_23480	COG2270	Major facilitator Superfamily
At12D13_23510	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_23540	COG0494	nUDIX hydrolase
At12D13_23560	COG0793	Belongs to the peptidase S41A family
At12D13_23580	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
At12D13_23590	COG0799	negative regulation of ribosome biogenesis
At12D13_23600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
At12D13_23610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
At12D13_23620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
At12D13_23630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
At12D13_23660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
At12D13_23670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
At12D13_23720	COG0066	3-isopropylmalate dehydratase activity
At12D13_23730	COG0473	3-isopropylmalate dehydrogenase activity
At12D13_23740	COG1858	cytochrome C peroxidase
At12D13_23750	COG1797	cobyrinic acid a,c-diamide synthase activity
At12D13_23760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_23760	COG1648	precorrin-2 dehydrogenase activity
At12D13_23770	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
At12D13_23900	COG1492	cobalamin metabolic process
At12D13_23930	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_23940	COG3254	rhamnose metabolic process
At12D13_23950	COG0246	Mannitol dehydrogenase
At12D13_23960	COG1063	alcohol dehydrogenase
At12D13_24000	COG4214	carbohydrate transport
At12D13_24010	COG1129	ABC transporter
At12D13_24020	COG2186	Transcriptional regulator
At12D13_24030	COG2721	sulfolactate sulfo-lyase activity
At12D13_24040	COG0138	bifunctional purine biosynthesis protein purh
At12D13_24060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
At12D13_24060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
At12D13_24070	COG0501	Belongs to the peptidase M48B family
At12D13_24090	COG1475	DNA binding
At12D13_24100	COG1192	Involved in chromosome partitioning
At12D13_24110	COG0357	Ribosomal RNA small subunit methyltransferase G
At12D13_24120	COG0445	tRNA wobble uridine modification
At12D13_24130	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
At12D13_24140	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
At12D13_24160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
At12D13_24170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
At12D13_24180	COG0424	maF-like protein
At12D13_24190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_24200	COG0237	dephospho-CoA kinase activity
At12D13_24210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
At12D13_24220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
At12D13_24230	COG3030	protein affecting phage T7 exclusion by the F plasmid
At12D13_24250	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
At12D13_24280	COG0187	DNA topoisomerase II activity
At12D13_24300	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_24330	COG0135	phosphoribosylanthranilate isomerase activity
At12D13_24340	COG0133	tryptophan synthase activity
At12D13_24350	COG0159	tryptophan synthase activity
At12D13_24360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
At12D13_24410	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
At12D13_24430	COG2205	protein histidine kinase activity
At12D13_24440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
At12D13_24450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_24460	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
At12D13_24460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
At12D13_24470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
At12D13_24480	COG0642	Histidine kinase
At12D13_24490	COG0745	RESPONSE REGULATOR receiver
At12D13_24500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
At12D13_24520	COG1072	(Pantothenic acid kinase))
At12D13_24530	COG0140	phosphoribosyl-ATP diphosphatase activity
At12D13_24540	COG0107	imidazoleglycerol-phosphate synthase activity
At12D13_24550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
At12D13_24560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
At12D13_24580	COG0131	Imidazoleglycerol-phosphate dehydratase
At12D13_24590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
At12D13_24600	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
At12D13_24620	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
At12D13_24650	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
At12D13_24670	COG1643	Atp-dependent helicase
At12D13_24710	COG0514	ATP-dependent DNA helicase (RecQ)
At12D13_24760	COG1072	(Pantothenic acid kinase))
At12D13_24780	COG1780	Probably involved in ribonucleotide reductase function
At12D13_24820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
At12D13_24880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_24900	COG2813	Specifically methylates the guanine in position
At12D13_24910	COG1185	polyribonucleotide nucleotidyltransferase activity
At12D13_24920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
At12D13_24930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
At12D13_24940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
At12D13_24950	COG3064	Membrane
At12D13_24950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
At12D13_24980	COG0779	Required for maturation of 30S ribosomal subunits
At12D13_24990	COG2814	Major facilitator Superfamily
At12D13_25000	COG2951	lytic endotransglycosylase activity
At12D13_25010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
At12D13_25030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
At12D13_25040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
At12D13_25060	COG2816	NAD+ diphosphatase activity
At12D13_25070	COG1605	Chorismate mutase
At12D13_25070	COG0077	Prephenate dehydratase
At12D13_25080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
At12D13_25090	COG3474	cytochrome
At12D13_25120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
At12D13_25130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
At12D13_25140	COG1278	Cold shock
At12D13_25150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_25170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D13_25170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
At12D13_25190	COG0333	Belongs to the bacterial ribosomal protein bL32 family
At12D13_25250	COG2900	Belongs to the SlyX family
At12D13_25270	COG0484	heat shock protein binding
At12D13_25280	COG0443	Heat shock 70 kDa protein
At12D13_25300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
At12D13_25350	COG0295	cytidine deaminase activity
At12D13_25360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
At12D13_25370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
At12D13_25380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
At12D13_25400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
At12D13_25410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
At12D13_25420	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
At12D13_25440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
At12D13_25450	COG1845	cytochrome c oxidase, subunit III
At12D13_25460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_25480	COG0477	Major facilitator Superfamily
At12D13_25490	COG0067	glutamate synthase
At12D13_25490	COG0070	glutamate synthase
At12D13_25490	COG0069	glutamate synthase activity
At12D13_25500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
At12D13_25530	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
At12D13_25550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
At12D13_25610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_25650	COG0848	biopolymer transport protein
At12D13_25670	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_25700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_25710	COG3454	Phosphonate metabolism
At12D13_25720	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
At12D13_25730	COG3639	organic phosphonate transmembrane transporter activity
At12D13_25740	COG3639	organic phosphonate transmembrane transporter activity
At12D13_25750	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
At12D13_25760	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
At12D13_25780	COG4778	phosphonate C-P lyase system protein PhnL
At12D13_25790	COG4107	phosphonate C-P lyase system protein PhnK
At12D13_25800	COG3627	carbon phosphorus lyase activity
At12D13_25820	COG3626	phosphonate metabolism
At12D13_25830	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
At12D13_25840	COG3624	Phosphonate C-P lyase system protein PhnG
At12D13_25850	COG2188	Transcriptional regulator
At12D13_25860	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
At12D13_25870	COG0837	glucose binding
At12D13_25880	COG1803	Methylglyoxal synthase
At12D13_25890	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
At12D13_25900	COG4166	transmembrane transport
At12D13_25910	COG4174	ABC transporter (Permease)
At12D13_25920	COG4239	(ABC) transporter, permease
At12D13_25930	COG4172	Belongs to the ABC transporter superfamily
At12D13_25940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_25950	COG0174	glutamine synthetase
At12D13_25960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_25970	COG3265	gluconokinase activity
At12D13_25980	COG1174	glycine betaine transport
At12D13_25990	COG1125	glycine betaine transport
At12D13_26000	COG1174	glycine betaine transport
At12D13_26010	COG1732	Glycine betaine
At12D13_26030	COG1959	2 iron, 2 sulfur cluster binding
At12D13_26040	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_26100	COG0697	spore germination
At12D13_26130	COG0791	NLP P60 protein
At12D13_26150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
At12D13_26160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
At12D13_26230	COG4964	Belongs to the GSP D family
At12D13_26310	COG3422	double-strand break repair
At12D13_26320	COG3757	hydrolase, family 25
At12D13_26330	COG0697	spore germination
At12D13_26340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_26400	COG0481	GTPase activity
At12D13_26410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D13_26440	COG1396	sequence-specific DNA binding
At12D13_26470	COG1917	Cupin 2, conserved barrel domain protein
At12D13_26470	COG2169	Transcriptional regulator
At12D13_26480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D13_26530	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
At12D13_26540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
At12D13_26550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
At12D13_26570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
At12D13_26580	COG0072	phenylalanine-tRNA ligase activity
At12D13_26580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
At12D13_26590	COG0667	Aldo Keto reductase
At12D13_26620	COG0667	Aldo Keto reductase
At12D13_26630	COG4977	sequence-specific DNA binding
At12D13_26680	COG1570	exodeoxyribonuclease VII activity
At12D13_26690	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_26710	COG1846	Transcriptional regulator
At12D13_26720	COG0697	spore germination
At12D13_26730	COG2309	aminopeptidase activity
At12D13_26740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
At12D13_26750	COG1393	Belongs to the ArsC family
At12D13_26800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
At12D13_26800	COG0519	Catalyzes the synthesis of GMP from XMP
At12D13_26830	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
At12D13_26890	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
At12D13_26910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
At12D13_26930	COG1968	undecaprenyl-diphosphatase activity
At12D13_26970	COG0284	orotidine-5'-phosphate decarboxylase activity
At12D13_26990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
At12D13_27000	COG0592	DNA-directed DNA polymerase activity
At12D13_27010	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
At12D13_27020	COG0792	nuclease activity
At12D13_27050	COG1175	transmembrane transport
At12D13_27060	COG0395	ABC-type sugar transport system, permease component
At12D13_27070	COG3842	ATPase activity
At12D13_27090	COG0189	ligase activity
At12D13_27100	COG0606	chelatase, subunit chli
At12D13_27110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
At12D13_27120	COG1280	lysine exporter protein (LysE YggA)
At12D13_27130	COG0756	dUTP diphosphatase activity
At12D13_27140	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
At12D13_27150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
At12D13_27180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
At12D13_27190	COG2226	methyltransferase
At12D13_27200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
At12D13_27210	COG1024	Enoyl-CoA hydratase
At12D13_27220	COG0268	Binds directly to 16S ribosomal RNA
At12D13_27260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_27280	COG0640	Transcriptional regulator
At12D13_27380	COG3842	ATPase activity
At12D13_27390	COG4209	transmembrane transport
At12D13_27400	COG0395	ABC-type sugar transport system, permease component
At12D13_27410	COG1653	transport
At12D13_27430	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_27450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_27470	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_27500	COG1846	Transcriptional regulator
At12D13_27500	COG1940	carbohydrate kinase activity
At12D13_27510	COG2197	response regulator
At12D13_27520	COG0601	transmembrane transport
At12D13_27570	COG0747	negative chemotaxis
At12D13_27600	COG1446	asparaginase
At12D13_27620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_27630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_27640	COG0601	transmembrane transport
At12D13_27720	COG1215	transferase activity, transferring glycosyl groups
At12D13_27740	COG0025	NhaP-type Na H and K H
At12D13_27750	COG4178	(ABC) transporter
At12D13_27760	COG3706	GGDEF domain
At12D13_27770	COG1609	Transcriptional regulator
At12D13_27800	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_27810	COG1735	metal-dependent hydrolase with the TIM-barrel fold
At12D13_27880	COG1794	racemase activity, acting on amino acids and derivatives
At12D13_27890	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_27900	COG1309	transcriptional regulator
At12D13_27910	COG2233	PERMEase
At12D13_27990	COG1595	DNA-templated transcription, initiation
At12D13_28010	COG0395	ABC-type sugar transport system, permease component
At12D13_28020	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_28040	COG3842	ATPase activity
At12D13_28110	COG1653	transport
At12D13_28130	COG0395	ABC-type sugar transport system, permease component
At12D13_28140	COG3842	ATPase activity
At12D13_28150	COG0395	ABC-type sugar transport system, permease component
At12D13_28160	COG1175	transmembrane transport
At12D13_28220	COG1609	Transcriptional regulator
At12D13_28240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_28250	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_28260	COG3842	ATPase activity
At12D13_28270	COG0395	ABC-type sugar transport system, permease component
At12D13_28280	COG1175	transmembrane transport
At12D13_28290	COG1653	transport
At12D13_28300	COG1309	transcriptional regulator
At12D13_28310	COG0673	inositol 2-dehydrogenase activity
At12D13_28340	COG0673	inositol 2-dehydrogenase activity
At12D13_28370	COG1278	Cold shock
At12D13_28390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D13_28450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D13_28490	COG0395	ABC-type sugar transport system, permease component
At12D13_28500	COG1175	transmembrane transport
At12D13_28540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_28550	COG3618	amidohydrolase
At12D13_28560	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_28570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_28580	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_28590	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
At12D13_28600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_28610	COG2186	Transcriptional regulator
At12D13_28710	COG2223	nitrite transmembrane transporter activity
At12D13_28720	COG0583	DNA-binding transcription factor activity
At12D13_28730	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_28750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_28760	COG2084	Dehydrogenase
At12D13_28790	COG1609	Transcriptional regulator
At12D13_28800	COG1063	alcohol dehydrogenase
At12D13_28810	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_28830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_28840	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
At12D13_28850	COG1175	transmembrane transport
At12D13_28860	COG0395	ABC-type sugar transport system, permease component
At12D13_28890	COG0395	ABC-type sugar transport system, permease component
At12D13_28920	COG0626	cystathionine gamma-synthase activity
At12D13_28940	COG0328	RNA-DNA hybrid ribonuclease activity
At12D13_28950	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D13_28970	COG1121	(ABC) transporter
At12D13_28980	COG0523	cobalamin synthesis protein
At12D13_29010	COG0523	cobalamin synthesis protein
At12D13_29020	COG1653	transport
At12D13_29030	COG1175	transmembrane transport
At12D13_29040	COG0395	ABC-type sugar transport system, permease component
At12D13_29050	COG3842	ATPase activity
At12D13_29080	COG3047	cAMP biosynthetic process
At12D13_29130	COG0583	DNA-binding transcription factor activity
At12D13_29140	COG1879	ABC-type sugar transport system periplasmic component
At12D13_29150	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_29160	COG1129	ABC transporter
At12D13_29180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
At12D13_29190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_29210	COG3257	ureidoglycine aminohydrolase activity
At12D13_29230	COG5001	Diguanylate cyclase
At12D13_29240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_29260	COG0747	negative chemotaxis
At12D13_29270	COG0601	transmembrane transport
At12D13_29280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_29300	COG4608	Belongs to the ABC transporter superfamily
At12D13_29330	COG0129	dihydroxy-acid dehydratase activity
At12D13_29340	COG1879	ABC-type sugar transport system periplasmic component
At12D13_29350	COG1129	ABC transporter
At12D13_29360	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_29370	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_29380	COG2186	Transcriptional regulator
At12D13_29400	COG0587	DNA-directed DNA polymerase activity
At12D13_29410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_29460	COG0673	inositol 2-dehydrogenase activity
At12D13_29480	COG3842	ATPase activity
At12D13_29490	COG0395	ABC-type sugar transport system, permease component
At12D13_29500	COG1175	transmembrane transport
At12D13_29510	COG1653	transport
At12D13_29530	COG0673	inositol 2-dehydrogenase activity
At12D13_29560	COG5001	Diguanylate cyclase
At12D13_29560	COG3300	MHYT domain
At12D13_29570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_29590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
At12D13_29600	COG2894	cell division
At12D13_29610	COG0850	regulation of cytokinetic process
At12D13_29620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_29630	COG2186	Transcriptional regulator
At12D13_29640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_29660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_29670	COG1063	alcohol dehydrogenase
At12D13_29680	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_29710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_29720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_29730	COG4172	Belongs to the ABC transporter superfamily
At12D13_29740	COG1921	L-seryl-tRNASec selenium transferase activity
At12D13_29770	COG3964	amidohydrolase
At12D13_29790	COG0601	transmembrane transport
At12D13_29800	COG0747	negative chemotaxis
At12D13_29810	COG0438	transferase activity, transferring glycosyl groups
At12D13_29890	COG4989	oxidoreductase activity
At12D13_29920	COG3842	ATPase activity
At12D13_29930	COG1653	transport
At12D13_29940	COG1175	transmembrane transport
At12D13_29950	COG0395	ABC-type sugar transport system, permease component
At12D13_29960	COG1501	Belongs to the glycosyl hydrolase 31 family
At12D13_29970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_29980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_29990	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
At12D13_30000	COG0352	thiamine-phosphate diphosphorylase activity
At12D13_30010	COG0351	phosphomethylpyrimidine kinase
At12D13_30020	COG1522	sequence-specific DNA binding
At12D13_30030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
At12D13_30040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_30070	COG2204	response regulator
At12D13_30110	COG1215	transferase activity, transferring glycosyl groups
At12D13_30130	COG2942	2-epimerase
At12D13_30200	COG2197	response regulator
At12D13_30260	COG3307	-O-antigen
At12D13_30270	COG1596	polysaccharide export
At12D13_30280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
At12D13_30310	COG2972	Histidine kinase
At12D13_30310	COG0840	transmembrane signaling receptor activity
At12D13_30320	COG1388	LysM domain
At12D13_30320	COG1376	ErfK ybiS ycfS ynhG family protein
At12D13_30340	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_30360	COG2094	Belongs to the DNA glycosylase MPG family
At12D13_30390	COG1609	Transcriptional regulator
At12D13_30400	COG1653	transport
At12D13_30430	COG3842	ATPase activity
At12D13_30450	COG0673	inositol 2-dehydrogenase activity
At12D13_30460	COG0602	queuosine metabolic process
At12D13_30470	COG0720	synthase
At12D13_30480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
At12D13_30490	COG0673	inositol 2-dehydrogenase activity
At12D13_30520	COG0395	ABC-type sugar transport system, permease component
At12D13_30570	COG0583	DNA-binding transcription factor activity
At12D13_30580	COG0281	malic enzyme
At12D13_30580	COG0280	phosphate acetyltransferase
At12D13_30610	COG0765	amino acid transport
At12D13_30630	COG2079	MmgE PrpD family protein
At12D13_30660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_30690	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
At12D13_30700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
At12D13_30710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
At12D13_30720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
At12D13_30730	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_30740	COG1129	ABC transporter
At12D13_30760	COG1473	amidohydrolase
At12D13_30810	COG0601	transmembrane transport
At12D13_30820	COG0583	DNA-binding transcription factor activity
At12D13_30830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_30840	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
At12D13_30880	COG1595	DNA-templated transcription, initiation
At12D13_30890	COG1120	ATPase activity
At12D13_30900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_30930	COG2226	methyltransferase
At12D13_30950	COG1120	ATPase activity
At12D13_30960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_31000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_31020	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_31030	COG0473	3-isopropylmalate dehydrogenase activity
At12D13_31040	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_31050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_31110	COG0601	transmembrane transport
At12D13_31120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_31130	COG4172	Belongs to the ABC transporter superfamily
At12D13_31140	COG1522	sequence-specific DNA binding
At12D13_31150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_31180	COG1126	abc transporter atp-binding protein
At12D13_31200	COG1473	amidohydrolase
At12D13_31210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31230	COG1959	2 iron, 2 sulfur cluster binding
At12D13_31250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_31260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31300	COG1960	acyl-CoA dehydrogenase activity
At12D13_31370	COG0667	Aldo Keto reductase
At12D13_31390	COG0583	DNA-binding transcription factor activity
At12D13_31430	COG0747	negative chemotaxis
At12D13_31440	COG1473	amidohydrolase
At12D13_31450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_31530	COG4608	Belongs to the ABC transporter superfamily
At12D13_31540	COG0444	Belongs to the ABC transporter superfamily
At12D13_31560	COG0601	transmembrane transport
At12D13_31580	COG2186	Transcriptional regulator
At12D13_31630	COG3453	Protein conserved in bacteria
At12D13_31630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_31640	COG0640	Transcriptional regulator
At12D13_31660	COG2391	methyltransferase activity
At12D13_31670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
At12D13_31690	COG0022	dehydrogenase e1 component
At12D13_31710	COG1960	acyl-CoA dehydrogenase activity
At12D13_31720	COG0183	Belongs to the thiolase family
At12D13_31740	COG1960	acyl-CoA dehydrogenase activity
At12D13_31750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D13_31780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
At12D13_31790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
At12D13_31800	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
At12D13_31810	COG4952	isomerase
At12D13_31820	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_31820	COG3347	Dehydrogenase
At12D13_31830	COG1349	DNA-binding transcription factor activity
At12D13_31850	COG1129	ABC transporter
At12D13_31860	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_31880	COG3254	rhamnose metabolic process
At12D13_31910	COG2264	protein methyltransferase activity
At12D13_31920	COG5001	Diguanylate cyclase
At12D13_31960	COG4335	DNA alkylation repair
At12D13_31970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
At12D13_31980	COG4208	sulfate ABC transporter
At12D13_32000	COG4150	thiosulfate binding
At12D13_32040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
At12D13_32060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
At12D13_32080	COG1040	competence protein
At12D13_32090	COG2226	methyltransferase
At12D13_32120	COG0494	nUDIX hydrolase
At12D13_32140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
At12D13_32150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
At12D13_32160	COG0653	protein targeting
At12D13_32170	COG0697	spore germination
At12D13_32240	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_32250	COG0246	Mannitol dehydrogenase
At12D13_32290	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_32310	COG1129	ABC transporter
At12D13_32370	COG2376	Dihydroxyacetone kinase
At12D13_32380	COG3273	potassium ion transport
At12D13_32380	COG0471	metal ion transport
At12D13_32420	COG0438	transferase activity, transferring glycosyl groups
At12D13_32440	COG2244	polysaccharide biosynthetic process
At12D13_32500	COG3206	protein involved in exopolysaccharide biosynthesis
At12D13_32500	COG0489	protein tyrosine kinase activity
At12D13_32540	COG0438	transferase activity, transferring glycosyl groups
At12D13_32580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
At12D13_32590	COG2273	Hydrolase Family 16
At12D13_32590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
At12D13_32680	COG1396	sequence-specific DNA binding
At12D13_32700	COG1129	ABC transporter
At12D13_32710	COG4214	carbohydrate transport
At12D13_32720	COG4213	ABC transporter substrate-binding protein
At12D13_32790	COG0625	glutathione transferase activity
At12D13_32800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
At12D13_32810	COG1396	sequence-specific DNA binding
At12D13_32810	COG3800	Transcriptional regulator
At12D13_32830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D13_32850	COG0300	oxidoreductase activity
At12D13_32890	COG2086	electron transfer activity
At12D13_32910	COG1250	3-hydroxyacyl-CoA dehydrogenase
At12D13_32920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
At12D13_32930	COG0165	Argininosuccinate lyase
At12D13_33000	COG2884	Cell division ATP-binding protein ftsE
At12D13_33040	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
At12D13_33070	COG0287	Prephenate dehydrogenase
At12D13_33080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
At12D13_33090	COG2226	methyltransferase
At12D13_33100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_33130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
At12D13_33140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
At12D13_33200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
At12D13_33210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
At12D13_33230	COG4974	Belongs to the 'phage' integrase family
At12D13_33240	COG0825	malonyl-CoA metabolic process
At12D13_33250	COG3034	peptidoglycan biosynthetic process
At12D13_33260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
At12D13_33260	COG0425	Belongs to the sulfur carrier protein TusA family
At12D13_33280	COG0523	cobalamin synthesis protein
At12D13_33290	COG1686	Belongs to the peptidase S11 family
At12D13_33300	COG1473	amidohydrolase
At12D13_33310	COG1959	2 iron, 2 sulfur cluster binding
At12D13_33320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
At12D13_33340	COG0534	Mate efflux family protein
At12D13_33400	COG2226	methyltransferase
At12D13_33470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
At12D13_33510	COG1629	transport
At12D13_33510	COG4774	siderophore transport
At12D13_33520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
At12D13_33530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_33540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_33550	COG1120	ATPase activity
At12D13_33580	COG4953	penicillin-binding protein 1C
At12D13_33590	COG2373	Large extracellular alpha-helical protein
At12D13_33600	COG2835	tetraacyldisaccharide 4'-kinase activity
At12D13_33620	COG3118	belongs to the thioredoxin family
At12D13_33640	COG0625	glutathione transferase activity
At12D13_33650	COG0482	sulfurtransferase activity
At12D13_33680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_33710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
At12D13_33720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
At12D13_33730	COG0037	tRNA processing
At12D13_33750	COG2885	chlorophyll binding
At12D13_33760	COG0823	Involved in the tonB-independent uptake of proteins
At12D13_33800	COG0824	Thioesterase
At12D13_33820	COG0494	nUDIX hydrolase
At12D13_33850	COG2255	four-way junction helicase activity
At12D13_33860	COG0632	four-way junction helicase activity
At12D13_33870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
At12D13_33880	COG0840	transmembrane signaling receptor activity
At12D13_33890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_33900	COG0217	transcriptional regulatory protein
At12D13_33930	COG1692	metallophosphoesterase
At12D13_33950	COG1253	flavin adenine dinucleotide binding
At12D13_34010	COG0126	phosphoglycerate kinase activity
At12D13_34020	COG3588	fructose-bisphosphate aldolase
At12D13_34070	COG0254	rRNA binding
At12D13_34090	COG1132	(ABC) transporter
At12D13_34140	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_34200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
At12D13_34210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
At12D13_34220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
At12D13_34230	COG0457	Tetratricopeptide repeat
At12D13_34240	COG3750	Belongs to the UPF0335 family
At12D13_34280	COG0469	pyruvate kinase activity
At12D13_34290	COG3108	Peptidase M15
At12D13_34300	COG2204	response regulator
At12D13_34310	COG1164	Oligoendopeptidase f
At12D13_34320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
At12D13_34340	COG5310	Homospermidine synthase
At12D13_34360	COG0737	Belongs to the 5'-nucleotidase family
At12D13_34370	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
At12D13_34380	COG0330	HflC and HflK could
At12D13_34430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D13_34440	COG2951	lytic endotransglycosylase activity
At12D13_34470	COG2205	protein histidine kinase activity
At12D13_34490	COG0070	glutamate synthase
At12D13_34490	COG0067	glutamate synthase
At12D13_34490	COG0069	glutamate synthase activity
At12D13_34510	COG0745	RESPONSE REGULATOR receiver
At12D13_34520	COG2205	protein histidine kinase activity
At12D13_34530	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
At12D13_34540	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
At12D13_34560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
At12D13_34580	COG0252	asparaginase activity
At12D13_34600	COG1027	Aspartate ammonia-lyase
At12D13_34610	COG2186	Transcriptional regulator
At12D13_34690	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_34700	COG0517	IMP dehydrogenase activity
At12D13_34700	COG4175	Glycine betaine
At12D13_34710	COG2986	histidine ammonia-lyase
At12D13_34720	COG2814	Major facilitator Superfamily
At12D13_34750	COG1522	sequence-specific DNA binding
At12D13_34760	COG0583	DNA-binding transcription factor activity
At12D13_34770	COG0667	Aldo Keto reductase
At12D13_34790	COG1335	isochorismatase
At12D13_34810	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_34820	COG3254	rhamnose metabolic process
At12D13_34850	COG2721	sulfolactate sulfo-lyase activity
At12D13_34860	COG1129	ABC transporter
At12D13_34880	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_34890	COG1879	ABC-type sugar transport system periplasmic component
At12D13_34910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
At12D13_34940	COG0583	DNA-binding transcription factor activity
At12D13_35000	COG1607	acyl-coa hydrolase
At12D13_35040	COG2308	Evidence 4 Homologs of previously reported genes of
At12D13_35040	COG2307	Protein conserved in bacteria
At12D13_35070	COG0488	(ABC) transporter
At12D13_35080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_35090	COG1304	FMN binding
At12D13_35110	COG1846	Transcriptional regulator
At12D13_35130	COG1070	Carbohydrate kinase
At12D13_35140	COG1830	Aldolase
At12D13_35150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
At12D13_35160	COG0667	Aldo Keto reductase
At12D13_35180	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_35190	COG1129	ABC transporter
At12D13_35250	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_35280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
At12D13_35310	COG0395	ABC-type sugar transport system, permease component
At12D13_35340	COG3842	ATPase activity
At12D13_35370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
At12D13_35370	COG1648	precorrin-2 dehydrogenase activity
At12D13_35380	COG0243	molybdopterin cofactor binding
At12D13_35410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
At12D13_35420	COG1116	anion transmembrane transporter activity
At12D13_35430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_35440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_35460	COG3707	response regulator
At12D13_35470	COG1802	Transcriptional regulator
At12D13_35480	COG1914	H( )-stimulated, divalent metal cation uptake system
At12D13_35490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_35500	COG4336	lyase activity
At12D13_35510	COG1984	allophanate hydrolase subunit 2
At12D13_35520	COG4770	biotin carboxylase activity
At12D13_35530	COG0366	Alpha amylase catalytic
At12D13_35550	COG4771	TonB-dependent receptor
At12D13_35560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
At12D13_35600	COG1414	Transcriptional regulator
At12D13_35610	COG1475	DNA binding
At12D13_35620	COG1192	Involved in chromosome partitioning
At12D13_35690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
At12D13_35720	COG2986	histidine ammonia-lyase
At12D13_35730	COG1228	amidohydrolase
At12D13_35740	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_35800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_35840	COG0583	DNA-binding transcription factor activity
At12D13_35850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_35860	COG3938	Belongs to the proline racemase family
At12D13_35870	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_35890	COG3448	diguanylate cyclase activity
At12D13_35890	COG4175	Glycine betaine
At12D13_35910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_35920	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_35930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_35990	COG0673	inositol 2-dehydrogenase activity
At12D13_36000	COG0673	inositol 2-dehydrogenase activity
At12D13_36020	COG1175	transmembrane transport
At12D13_36030	COG0395	ABC-type sugar transport system, permease component
At12D13_36040	COG3842	ATPase activity
At12D13_36060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_36070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_36120	COG0583	DNA-binding transcription factor activity
At12D13_36130	COG0346	lactoylglutathione lyase activity
At12D13_36160	COG1574	metal-dependent hydrolase with the TIM-barrel fold
At12D13_36180	COG2814	Major facilitator Superfamily
At12D13_36210	COG0583	DNA-binding transcription factor activity
At12D13_36220	COG0477	Major facilitator Superfamily
At12D13_36320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
At12D13_36340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
At12D13_36350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D13_36360	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
At12D13_36430	COG0697	spore germination
At12D13_36440	COG0673	inositol 2-dehydrogenase activity
At12D13_36480	COG0477	Major facilitator Superfamily
At12D13_36490	COG0642	Histidine kinase
At12D13_36500	COG0745	RESPONSE REGULATOR receiver
At12D13_36510	COG2194	sulfuric ester hydrolase activity
At12D13_36530	COG0583	DNA-binding transcription factor activity
At12D13_36540	COG4774	siderophore transport
At12D13_36570	COG1120	ATPase activity
At12D13_36590	COG3474	cytochrome
At12D13_36600	COG2137	regulation of response to DNA damage stimulus
At12D13_36610	COG3386	PFAM SMP-30 Gluconolaconase
At12D13_36630	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_36640	COG1129	ABC transporter
At12D13_36650	COG1879	ABC-type sugar transport system periplasmic component
At12D13_36660	COG4585	Histidine kinase
At12D13_36670	COG2197	response regulator
At12D13_36690	COG2133	pyrroloquinoline quinone binding
At12D13_36710	COG0500	methyltransferase
At12D13_36720	COG0564	pseudouridine synthase activity
At12D13_36750	COG4175	Glycine betaine
At12D13_36750	COG0517	IMP dehydrogenase activity
At12D13_36760	COG4176	ABC-type proline glycine betaine transport system permease component
At12D13_36780	COG0784	Response regulator, receiver
At12D13_36780	COG4191	Histidine kinase
At12D13_36790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_36800	COG0489	protein tyrosine kinase activity
At12D13_36800	COG3206	protein involved in exopolysaccharide biosynthesis
At12D13_36810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
At12D13_36820	COG1215	transferase activity, transferring glycosyl groups
At12D13_36830	COG1215	transferase activity, transferring glycosyl groups
At12D13_36840	COG1215	transferase activity, transferring glycosyl groups
At12D13_36850	COG0438	transferase activity, transferring glycosyl groups
At12D13_36860	COG2273	Hydrolase Family 16
At12D13_36870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
At12D13_36880	COG2244	polysaccharide biosynthetic process
At12D13_36890	COG0463	Glycosyl transferase, family 2
At12D13_36900	COG2327	Polysaccharide pyruvyl transferase
At12D13_36910	COG1215	transferase activity, transferring glycosyl groups
At12D13_36950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
At12D13_36960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_36990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_36990	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_37040	COG0033	Phosphoglucomutase
At12D13_37050	COG0297	glycogen (starch) synthase activity
At12D13_37060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
At12D13_37070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_37080	COG0058	SHG alpha-glucan phosphorylase activity
At12D13_37100	COG1794	racemase activity, acting on amino acids and derivatives
At12D13_37110	COG1522	sequence-specific DNA binding
At12D13_37130	COG2084	Dehydrogenase
At12D13_37140	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_37150	COG1063	alcohol dehydrogenase
At12D13_37170	COG4988	ABC transporter
At12D13_37180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
At12D13_37200	COG1294	oxidase, subunit
At12D13_37260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
At12D13_37270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
At12D13_37320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
At12D13_37330	COG0539	negative regulation of cytoplasmic translation
At12D13_37390	COG4221	oxidoreductase activity
At12D13_37400	COG0006	proline dipeptidase activity
At12D13_37410	COG0747	negative chemotaxis
At12D13_37420	COG0601	transmembrane transport
At12D13_37430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_37440	COG0444	Belongs to the ABC transporter superfamily
At12D13_37450	COG4608	Belongs to the ABC transporter superfamily
At12D13_37480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_37520	COG0410	ABC transporter
At12D13_37530	COG0559	Belongs to the binding-protein-dependent transport system permease family
At12D13_37570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
At12D13_37580	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_37620	COG4993	Dehydrogenase
At12D13_37630	COG3685	Protein conserved in bacteria
At12D13_37690	COG0693	protein deglycase activity
At12D13_37740	COG0189	ligase activity
At12D13_37750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_37760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
At12D13_37780	COG0583	DNA-binding transcription factor activity
At12D13_37790	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_37800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
At12D13_37810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_37820	COG1116	anion transmembrane transporter activity
At12D13_37840	COG1522	sequence-specific DNA binding
At12D13_37870	COG0784	Response regulator, receiver
At12D13_37890	COG3920	Histidine kinase
At12D13_37910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
At12D13_37940	COG0019	diaminopimelate decarboxylase activity
At12D13_37960	COG0513	Belongs to the DEAD box helicase family
At12D13_37970	COG0527	aspartate kinase activity
At12D13_37990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
At12D13_38000	COG2890	protein-(glutamine-N5) methyltransferase activity
At12D13_38020	COG0542	response to heat
At12D13_38030	COG1196	nuclear chromosome segregation
At12D13_38030	COG0739	heme binding
At12D13_38030	COG0741	lytic transglycosylase activity
At12D13_38070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_38090	COG2186	Transcriptional regulator
At12D13_38100	COG0747	negative chemotaxis
At12D13_38110	COG0601	transmembrane transport
At12D13_38120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_38130	COG4172	Belongs to the ABC transporter superfamily
At12D13_38140	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_38180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_38200	COG0439	Biotin carboxylase
At12D13_38220	COG1984	allophanate hydrolase subunit 2
At12D13_38240	COG3842	ATPase activity
At12D13_38250	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_38280	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_38300	COG3842	ATPase activity
At12D13_38310	COG0726	polysaccharide deacetylase
At12D13_38330	COG0523	cobalamin synthesis protein
At12D13_38400	COG1881	PFAM PEBP family protein
At12D13_38450	COG1278	Cold shock
At12D13_38460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D13_38470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
At12D13_38510	COG0300	oxidoreductase activity
At12D13_38530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_38530	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_38540	COG4311	Sarcosine oxidase, delta subunit
At12D13_38550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_38560	COG4977	sequence-specific DNA binding
At12D13_38580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
At12D13_38590	COG2218	PFAM glutamate synthase alpha subunit domain protein
At12D13_38600	COG0069	glutamate synthase activity
At12D13_38610	COG0174	glutamine synthetase
At12D13_38660	COG1126	abc transporter atp-binding protein
At12D13_38670	COG1454	alcohol dehydrogenase
At12D13_38690	COG2267	carboxylic ester hydrolase activity
At12D13_38710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
At12D13_38720	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_38750	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_38760	COG1177	transmembrane transport
At12D13_38770	COG3842	ATPase activity
At12D13_38800	COG3842	ATPase activity
At12D13_38810	COG0395	ABC-type sugar transport system, permease component
At12D13_38840	COG1053	succinate dehydrogenase
At12D13_38840	COG3976	FMN-binding domain protein
At12D13_38850	COG1609	Transcriptional regulator
At12D13_38860	COG4172	Belongs to the ABC transporter superfamily
At12D13_38870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_38880	COG0601	transmembrane transport
At12D13_38890	COG4166	transmembrane transport
At12D13_38900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_38930	COG2828	Protein conserved in bacteria
At12D13_38940	COG0583	DNA-binding transcription factor activity
At12D13_38960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_38980	COG1280	lysine exporter protein (LysE YggA)
At12D13_39010	COG0583	DNA-binding transcription factor activity
At12D13_39030	COG0511	ligase activity, forming carbon-carbon bonds
At12D13_39040	COG0439	Biotin carboxylase
At12D13_39070	COG1984	allophanate hydrolase subunit 2
At12D13_39080	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
At12D13_39110	COG4221	oxidoreductase activity
At12D13_39120	COG0765	amino acid transport
At12D13_39130	COG0765	amino acid transport
At12D13_39140	COG1126	abc transporter atp-binding protein
At12D13_39150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_39160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_39190	COG0583	DNA-binding transcription factor activity
At12D13_39210	COG0583	DNA-binding transcription factor activity
At12D13_39220	COG2814	Major facilitator Superfamily
At12D13_39250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_39270	COG2207	Transcriptional regulator
At12D13_39280	COG0668	transmembrane transport
At12D13_39300	COG4566	intracellular signal transduction
At12D13_39340	COG0668	transmembrane transport
At12D13_39350	COG4191	Histidine kinase
At12D13_39360	COG0784	Response regulator, receiver
At12D13_39360	COG2205	protein histidine kinase activity
At12D13_39360	COG5002	protein histidine kinase activity
At12D13_39370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
At12D13_39400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
At12D13_39410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_39450	COG0047	phosphoribosylformylglycinamidine synthase activity
At12D13_39460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_39480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
At12D13_39480	COG0446	pyridine nucleotide-disulphide oxidoreductase
At12D13_39500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
At12D13_39530	COG1309	transcriptional regulator
At12D13_39540	COG1063	alcohol dehydrogenase
At12D13_39560	COG1879	ABC-type sugar transport system periplasmic component
At12D13_39580	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_39830	COG3501	Rhs element vgr protein
At12D13_39870	COG5001	Diguanylate cyclase
At12D13_39900	COG1253	flavin adenine dinucleotide binding
At12D13_39930	COG3842	ATPase activity
At12D13_39940	COG0395	ABC-type sugar transport system, permease component
At12D13_39950	COG1175	transmembrane transport
At12D13_39980	COG0673	inositol 2-dehydrogenase activity
At12D13_39990	COG1609	Transcriptional regulator
At12D13_40020	COG1879	ABC-type sugar transport system periplasmic component
At12D13_40030	COG1129	ABC transporter
At12D13_40040	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_40050	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_40060	COG1609	Transcriptional regulator
At12D13_40080	COG0673	inositol 2-dehydrogenase activity
At12D13_40200	COG0714	Associated with various cellular activities
At12D13_40210	COG3256	nitric oxide reductase
At12D13_40270	COG0163	prenyltransferase activity
At12D13_40280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
At12D13_40290	COG3189	MarR family transcriptional regulator
At12D13_40370	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
At12D13_40390	COG4459	periplasmic nitrate reductase
At12D13_40420	COG0243	molybdopterin cofactor binding
At12D13_40440	COG3005	denitrification pathway
At12D13_40470	COG1960	acyl-CoA dehydrogenase activity
At12D13_40480	COG0583	DNA-binding transcription factor activity
At12D13_40490	COG1609	Transcriptional regulator
At12D13_40510	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_40530	COG3842	ATPase activity
At12D13_40550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
At12D13_40570	COG1473	amidohydrolase
At12D13_40600	COG0747	negative chemotaxis
At12D13_40610	COG0601	transmembrane transport
At12D13_40620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_40630	COG0444	Belongs to the ABC transporter superfamily
At12D13_40640	COG4608	Belongs to the ABC transporter superfamily
At12D13_40650	COG0583	DNA-binding transcription factor activity
At12D13_40660	COG0747	negative chemotaxis
At12D13_40680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_40690	COG0154	amidase activity
At12D13_40700	COG0693	protein deglycase activity
At12D13_40720	COG1473	amidohydrolase
At12D13_40730	COG4172	Belongs to the ABC transporter superfamily
At12D13_40740	COG2390	Transcriptional regulator
At12D13_40760	COG1175	transmembrane transport
At12D13_40770	COG0395	ABC-type sugar transport system, permease component
At12D13_40800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
At12D13_40820	COG1737	Transcriptional regulator
At12D13_40860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
At12D13_40890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
At12D13_40900	COG1414	Transcriptional regulator
At12D13_40910	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_40930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_40940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
At12D13_40950	COG1121	(ABC) transporter
At12D13_40960	COG0803	Belongs to the bacterial solute-binding protein 9 family
At12D13_40980	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
At12D13_40990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
At12D13_41000	COG3273	potassium ion transport
At12D13_41000	COG0471	metal ion transport
At12D13_41010	COG1253	flavin adenine dinucleotide binding
At12D13_41060	COG1609	Transcriptional regulator
At12D13_41070	COG1070	Carbohydrate kinase
At12D13_41080	COG2115	Belongs to the xylose isomerase family
At12D13_41100	COG0778	Nitroreductase
At12D13_41110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
At12D13_41120	COG2011	ABC-type metal ion transport system permease component
At12D13_41140	COG5001	Diguanylate cyclase
At12D13_41140	COG3300	MHYT domain
At12D13_41180	COG0800	Aldolase
At12D13_41220	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
At12D13_41290	COG0523	cobalamin synthesis protein
At12D13_41310	COG1846	Transcriptional regulator
At12D13_41320	COG1609	Transcriptional regulator
At12D13_41330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_41340	COG0673	inositol 2-dehydrogenase activity
At12D13_41350	COG3718	enzyme involved in inositol metabolism
At12D13_41370	COG3962	Belongs to the TPP enzyme family
At12D13_41380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_41440	COG0683	leucine binding
At12D13_41480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_41500	COG0747	negative chemotaxis
At12D13_41560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
At12D13_41570	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
At12D13_41580	COG1126	abc transporter atp-binding protein
At12D13_41590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_41600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_41610	COG0765	amino acid transport
At12D13_41620	COG0765	amino acid transport
At12D13_41640	COG3485	protocatechuate 3,4-dioxygenase
At12D13_41650	COG3485	protocatechuate 3,4-dioxygenase
At12D13_41660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
At12D13_41680	COG0583	DNA-binding transcription factor activity
At12D13_41710	COG1414	Transcriptional regulator
At12D13_41730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
At12D13_41740	COG0183	Belongs to the thiolase family
At12D13_41750	COG1609	Transcriptional regulator
At12D13_41780	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_41790	COG0673	inositol 2-dehydrogenase activity
At12D13_41810	COG1609	Transcriptional regulator
At12D13_41820	COG0395	ABC-type sugar transport system, permease component
At12D13_41830	COG1175	transmembrane transport
At12D13_41840	COG3842	ATPase activity
At12D13_41860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
At12D13_41900	COG1940	carbohydrate kinase activity
At12D13_41920	COG3842	ATPase activity
At12D13_41930	COG4149	molybdate abc transporter
At12D13_41950	COG0584	glycerophosphoryl diester phosphodiesterase
At12D13_41960	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_41970	COG0300	oxidoreductase activity
At12D13_42010	COG3842	ATPase activity
At12D13_42120	COG3177	Filamentation induced by cAMP protein fic
At12D13_42180	COG0385	Bile acid
At12D13_42190	COG0667	Aldo Keto reductase
At12D13_42200	COG0583	DNA-binding transcription factor activity
At12D13_42220	COG0179	Fumarylacetoacetate (FAA) hydrolase
At12D13_42240	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_42260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
At12D13_42280	COG1414	Transcriptional regulator
At12D13_42290	COG1132	(ABC) transporter
At12D13_42320	COG1216	Glycosyl transferase, family 2
At12D13_42320	COG0438	transferase activity, transferring glycosyl groups
At12D13_42360	COG3754	Rhamnan synthesis protein F
At12D13_42380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
At12D13_42390	COG1091	dTDP-4-dehydrorhamnose reductase activity
At12D13_42400	COG1088	dTDP-glucose 4,6-dehydratase activity
At12D13_42410	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
At12D13_42440	COG0444	Belongs to the ABC transporter superfamily
At12D13_42450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_42460	COG0601	transmembrane transport
At12D13_42470	COG2186	Transcriptional regulator
At12D13_42480	COG1312	Catalyzes the dehydration of D-mannonate
At12D13_42490	COG0747	negative chemotaxis
At12D13_42510	COG5001	Diguanylate cyclase
At12D13_42510	COG3300	MHYT domain
At12D13_42520	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_42540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D13_42560	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
At12D13_42570	COG0306	phosphate transporter
At12D13_42580	COG1392	Phosphate transport regulator
At12D13_42620	COG0745	RESPONSE REGULATOR receiver
At12D13_42630	COG5002	protein histidine kinase activity
At12D13_42660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
At12D13_42690	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_42720	COG3119	arylsulfatase activity
At12D13_42730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
At12D13_42740	COG3842	ATPase activity
At12D13_42750	COG0165	Argininosuccinate lyase
At12D13_42760	COG0395	ABC-type sugar transport system, permease component
At12D13_42770	COG1175	transmembrane transport
At12D13_42780	COG2182	Extracellular solute-binding protein
At12D13_42790	COG1940	carbohydrate kinase activity
At12D13_42850	COG1486	melibiose metabolic process
At12D13_42860	COG0747	negative chemotaxis
At12D13_42870	COG0601	transmembrane transport
At12D13_42880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_42890	COG4172	Belongs to the ABC transporter superfamily
At12D13_42900	COG1486	melibiose metabolic process
At12D13_42910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
At12D13_42920	COG1129	ABC transporter
At12D13_42920	COG0842	Transport permease protein
At12D13_42930	COG0842	Transport permease protein
At12D13_42960	COG0784	Response regulator, receiver
At12D13_42970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
At12D13_42990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_43000	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
At12D13_43040	COG0765	amino acid transport
At12D13_43060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
At12D13_43080	COG3938	Belongs to the proline racemase family
At12D13_43110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_43130	COG0765	amino acid transport
At12D13_43150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_43180	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_43210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_43230	COG0402	S-adenosylhomocysteine deaminase activity
At12D13_43240	COG0444	Belongs to the ABC transporter superfamily
At12D13_43250	COG4608	Belongs to the ABC transporter superfamily
At12D13_43260	COG1802	Transcriptional regulator
At12D13_43270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
At12D13_43320	COG3383	formate dehydrogenase (NAD+) activity
At12D13_43350	COG2770	Histidine kinase
At12D13_43350	COG2205	protein histidine kinase activity
At12D13_43360	COG0745	RESPONSE REGULATOR receiver
At12D13_43410	COG3237	CsbD-like
At12D13_43420	COG2197	response regulator
At12D13_43430	COG3920	Histidine kinase
At12D13_43440	COG2186	Transcriptional regulator
At12D13_43450	COG0747	negative chemotaxis
At12D13_43460	COG0601	transmembrane transport
At12D13_43480	COG0405	Gamma-glutamyltransferase
At12D13_43520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
At12D13_43530	COG3181	Tripartite tricarboxylate transporter family receptor
At12D13_43540	COG5265	(ABC) transporter
At12D13_43550	COG0488	(ABC) transporter
At12D13_43600	COG1049	propionate catabolic process, 2-methylcitrate cycle
At12D13_43610	COG0840	transmembrane signaling receptor activity
At12D13_43630	COG0110	maltose O-acetyltransferase activity
At12D13_43650	COG1063	alcohol dehydrogenase
At12D13_43660	COG3284	Transcriptional regulator
At12D13_43700	COG1129	ABC transporter
At12D13_43710	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_43720	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_43730	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_43750	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_43770	COG1126	abc transporter atp-binding protein
At12D13_43780	COG0765	amino acid transport
At12D13_43790	COG0765	amino acid transport
At12D13_43800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_43810	COG3608	succinylglutamate desuccinylase aspartoacylase
At12D13_43820	COG0006	proline dipeptidase activity
At12D13_43830	COG2423	ornithine cyclodeaminase activity
At12D13_43840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
At12D13_43850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
At12D13_43860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
At12D13_43870	COG1012	belongs to the aldehyde dehydrogenase family
At12D13_43880	COG1522	sequence-specific DNA binding
At12D13_43890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
At12D13_43950	COG2140	Oxalate decarboxylase
At12D13_43980	COG4566	intracellular signal transduction
At12D13_44000	COG0243	molybdopterin cofactor binding
At12D13_44010	COG0783	Belongs to the Dps family
At12D13_44050	COG0596	Alpha beta hydrolase
At12D13_44080	COG1764	response to oxidative stress
At12D13_44100	COG0745	RESPONSE REGULATOR receiver
At12D13_44180	COG0784	Response regulator, receiver
At12D13_44180	COG4191	Histidine kinase
At12D13_44190	COG0745	RESPONSE REGULATOR receiver
At12D13_44200	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_44210	COG1840	ABC-type Fe3 transport system, periplasmic component
At12D13_44230	COG3842	ATPase activity
At12D13_44240	COG0483	inositol monophosphate 1-phosphatase activity
At12D13_44270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_44320	COG2197	response regulator
At12D13_44330	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
At12D13_44340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
At12D13_44360	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
At12D13_44370	COG4310	Domain of unknown function (DUF2172)
At12D13_44380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_44390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
At12D13_44400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
At12D13_44410	COG2197	response regulator
At12D13_44420	COG4566	intracellular signal transduction
At12D13_44480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
At12D13_44520	COG0438	transferase activity, transferring glycosyl groups
At12D13_44550	COG1522	sequence-specific DNA binding
At12D13_44590	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_44610	COG0183	Belongs to the thiolase family
At12D13_44620	COG1414	Transcriptional regulator
At12D13_44640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
At12D13_44690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
At12D13_44770	COG1192	Involved in chromosome partitioning
At12D13_44780	COG1475	DNA binding
At12D13_44790	COG0640	Transcriptional regulator
At12D13_44820	COG1126	abc transporter atp-binding protein
At12D13_44830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
At12D13_44860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
At12D13_44880	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
At12D13_44930	COG1196	nuclear chromosome segregation
At12D13_44940	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
At12D13_44960	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
At12D13_45060	COG0667	Aldo Keto reductase
At12D13_45080	COG2814	Major facilitator Superfamily
At12D13_45120	COG2080	2 iron, 2 sulfur cluster binding
At12D13_45130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
At12D13_45140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_45150	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
At12D13_45160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
At12D13_45260	COG1280	lysine exporter protein (LysE YggA)
At12D13_45280	COG2197	response regulator
At12D13_45290	COG4585	Histidine kinase
At12D13_45320	COG1733	regulation of RNA biosynthetic process
At12D13_45390	COG1309	transcriptional regulator
At12D13_45410	COG0583	DNA-binding transcription factor activity
At12D13_45420	COG1073	alpha beta
At12D13_45430	COG1073	alpha beta
At12D13_45510	COG1132	(ABC) transporter
At12D13_45540	COG3920	Histidine kinase
At12D13_45570	COG0784	Response regulator, receiver
At12D13_45610	COG4095	Psort location CytoplasmicMembrane, score
At12D13_45670	COG0753	catalase activity
At12D13_45680	COG3685	Protein conserved in bacteria
At12D13_45750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_45760	COG0297	glycogen (starch) synthase activity
At12D13_45920	COG1609	Transcriptional regulator
At12D13_45970	COG0673	inositol 2-dehydrogenase activity
At12D13_45980	COG4608	Belongs to the ABC transporter superfamily
At12D13_46000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
At12D13_46010	COG0601	transmembrane transport
At12D13_46020	COG0747	negative chemotaxis
At12D13_46030	COG1802	Transcriptional regulator
At12D13_46050	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_46060	COG0583	DNA-binding transcription factor activity
At12D13_46170	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_46250	COG0395	ABC-type sugar transport system, permease component
At12D13_46270	COG3842	ATPase activity
At12D13_46280	COG1737	Transcriptional regulator
At12D13_46290	COG1846	Transcriptional regulator
At12D13_46320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_46350	COG0601	transmembrane transport
At12D13_46360	COG0747	negative chemotaxis
At12D13_46380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
At12D13_46390	COG1454	alcohol dehydrogenase
At12D13_46400	COG2186	Transcriptional regulator
At12D13_46410	COG3395	kinase activity
At12D13_46420	COG1609	Transcriptional regulator
At12D13_46510	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_46520	COG3920	Histidine kinase
At12D13_46530	COG0583	DNA-binding transcription factor activity
At12D13_46540	COG2267	carboxylic ester hydrolase activity
At12D13_46600	COG1505	serine-type exopeptidase activity
At12D13_46610	COG1505	serine-type exopeptidase activity
At12D13_46630	COG0642	Histidine kinase
At12D13_46640	COG0745	RESPONSE REGULATOR receiver
At12D13_46650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
At12D13_46660	COG0583	DNA-binding transcription factor activity
At12D13_46670	COG0372	Belongs to the citrate synthase family
At12D13_46710	COG4774	siderophore transport
At12D13_46720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
At12D13_46740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_46750	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
At12D13_46760	COG1120	ATPase activity
At12D13_46790	COG0640	Transcriptional regulator
At12D13_46800	COG0431	NADPH-dependent FMN reductase
At12D13_46820	COG0604	alcohol dehydrogenase
At12D13_46840	COG0583	DNA-binding transcription factor activity
At12D13_46850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
At12D13_46860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
At12D13_46900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
At12D13_46940	COG0784	Response regulator, receiver
At12D13_46940	COG4191	Histidine kinase
At12D13_46970	COG3177	Filamentation induced by cAMP protein fic
At12D13_47050	COG2268	Band 7 protein
At12D13_47080	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_47090	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_47100	COG0583	DNA-binding transcription factor activity
At12D13_47140	COG0583	DNA-binding transcription factor activity
At12D13_47160	COG1176	ABC-type spermidine putrescine transport system, permease component I
At12D13_47170	COG1177	transmembrane transport
At12D13_47180	COG3842	ATPase activity
At12D13_47190	COG2072	flavoprotein involved in K transport
At12D13_47230	COG0534	Mate efflux family protein
At12D13_47270	COG1609	Transcriptional regulator
At12D13_47280	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_47290	COG0673	inositol 2-dehydrogenase activity
At12D13_47300	COG1082	Xylose isomerase domain protein TIM barrel
At12D13_47320	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_47370	COG2972	Histidine kinase
At12D13_47370	COG0840	transmembrane signaling receptor activity
At12D13_47390	COG4221	oxidoreductase activity
At12D13_47400	COG1902	pentaerythritol trinitrate reductase activity
At12D13_47410	COG0596	Alpha beta hydrolase
At12D13_47430	COG3831	ATPase activity
At12D13_47440	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_47500	COG3734	2-keto-3-deoxy-galactonokinase
At12D13_47510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
At12D13_47520	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_47540	COG1175	transmembrane transport
At12D13_47550	COG0395	ABC-type sugar transport system, permease component
At12D13_47560	COG3842	ATPase activity
At12D13_47570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
At12D13_47580	COG1414	Transcriptional regulator
At12D13_47590	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_47600	COG3158	transport of potassium into the cell
At12D13_47620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_47680	COG0504	CTP synthase activity
At12D13_47690	COG0006	proline dipeptidase activity
At12D13_47700	COG4948	Mandelate Racemase Muconate Lactonizing
At12D13_47710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
At12D13_47730	COG0765	amino acid transport
At12D13_47830	COG0753	catalase activity
At12D13_47860	COG3685	Protein conserved in bacteria
At12D13_47890	COG1309	transcriptional regulator
At12D13_47900	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
At12D13_47910	COG2080	2 iron, 2 sulfur cluster binding
At12D13_47920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
At12D13_47930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
At12D13_47940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
At12D13_47990	COG0745	RESPONSE REGULATOR receiver
At12D13_48030	COG0784	Response regulator, receiver
At12D13_48030	COG4191	Histidine kinase
At12D13_48040	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_48070	COG1278	Cold shock
At12D13_48120	COG0410	ABC transporter
At12D13_48140	COG1172	Belongs to the binding-protein-dependent transport system permease family
At12D13_48190	COG3920	Histidine kinase
At12D13_48250	COG0411	ABC transporter
At12D13_48280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
At12D13_48300	COG1566	PFAM secretion protein HlyD family protein
At12D13_48340	COG2207	Transcriptional regulator
At12D13_48400	COG1192	Involved in chromosome partitioning
At12D13_48410	COG1475	DNA binding
At12D13_48420	COG1414	Transcriptional regulator
At12D13_48470	COG0395	ABC-type sugar transport system, permease component
At12D13_48560	COG0028	Belongs to the TPP enzyme family
At12D13_48670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_48700	COG0243	molybdopterin cofactor binding
At12D13_48730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
At12D13_48740	COG1845	cytochrome c oxidase, subunit III
At12D13_48850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
At12D13_48870	COG0297	glycogen (starch) synthase activity
At12D13_48880	COG2124	cytochrome p450
At12D13_48940	COG3685	Protein conserved in bacteria
At12D13_48990	COG1573	uracil-dna glycosylase
At12D13_49010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_49060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
At12D13_49170	COG1028	Short-chain dehydrogenase reductase Sdr
At12D13_49260	COG3177	Filamentation induced by cAMP protein fic
At12D13_49320	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
At12D13_49330	COG4585	Histidine kinase
At12D13_49340	COG0784	Response regulator, receiver
At12D13_49380	COG0583	DNA-binding transcription factor activity
At12D13_49400	COG0583	DNA-binding transcription factor activity
At12D13_49410	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_49420	COG0071	Belongs to the small heat shock protein (HSP20) family
At12D13_49440	COG1758	RNA polymerase activity
At12D13_49630	COG1487	ribonuclease activity
At12D13_49650	COG3706	GGDEF domain
At12D13_50180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
At12D13_50250	COG3750	Belongs to the UPF0335 family
At12D13_50440	COG0596	Alpha beta hydrolase