locus-tag	class	description
EML4058_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EML4058_00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EML4058_00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EML4058_00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EML4058_00025	COG1420	regulation of RNA biosynthetic process
EML4058_00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EML4058_00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4058_00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EML4058_00050	COG1137	ATPase activity
EML4058_00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EML4058_00065	COG0616	signal peptide processing
EML4058_00070	COG0776	regulation of translation
EML4058_00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EML4058_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EML4058_00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EML4058_00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EML4058_00115	COG0728	peptidoglycan biosynthetic process
EML4058_00125	COG0180	Tryptophanyl-tRNA synthetase
EML4058_00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EML4058_00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EML4058_00165	COG1702	phosphate starvation-inducible protein PhoH
EML4058_00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EML4058_00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EML4058_00185	COG1396	sequence-specific DNA binding
EML4058_00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EML4058_00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EML4058_00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_00210	COG0242	peptide deformylase activity
EML4058_00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EML4058_00220	COG0101	tRNA pseudouridine synthase activity
EML4058_00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4058_00235	COG2171	N-acyltransferase activity
EML4058_00245	COG0840	transmembrane signaling receptor activity
EML4058_00255	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4058_00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EML4058_00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EML4058_00295	COG0706	membrane insertase activity
EML4058_00300	COG0594	ribonuclease P activity
EML4058_00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EML4058_00310	COG0840	transmembrane signaling receptor activity
EML4058_00315	COG5002	protein histidine kinase activity
EML4058_00315	COG3850	Histidine kinase
EML4058_00325	COG2226	methyltransferase
EML4058_00330	COG3842	ATPase activity
EML4058_00335	COG1175	transmembrane transport
EML4058_00340	COG0395	ABC-type sugar transport system, permease component
EML4058_00355	COG0427	acetyl-CoA hydrolase
EML4058_00365	COG3938	Belongs to the proline racemase family
EML4058_00370	COG0418	dihydroorotase activity
EML4058_00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EML4058_00395	COG0166	Belongs to the GPI family
EML4058_00400	COG0318	PFAM AMP-dependent synthetase and ligase
EML4058_00405	COG3842	ATPase activity
EML4058_00410	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4058_00415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EML4058_00420	COG4774	siderophore transport
EML4058_00460	COG2326	polyphosphate kinase activity
EML4058_00465	COG5002	protein histidine kinase activity
EML4058_00470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EML4058_00475	COG0573	inorganic phosphate transmembrane transporter activity
EML4058_00485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EML4058_00490	COG0704	Plays a role in the regulation of phosphate uptake
EML4058_00495	COG0745	RESPONSE REGULATOR receiver
EML4058_00505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EML4058_00510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EML4058_00520	COG2967	ApaG domain
EML4058_00530	COG0717	Belongs to the dCTP deaminase family
EML4058_00765	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EML4058_00785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EML4058_00840	COG0167	dihydroorotate dehydrogenase activity
EML4058_00855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4058_00875	COG1959	2 iron, 2 sulfur cluster binding
EML4058_00880	COG1201	RNA secondary structure unwinding
EML4058_00900	COG0730	response to heat
EML4058_00910	COG1960	acyl-CoA dehydrogenase activity
EML4058_00915	COG0183	Belongs to the thiolase family
EML4058_00920	COG1250	3-hydroxyacyl-CoA dehydrogenase
EML4058_00920	COG1024	Enoyl-CoA hydratase
EML4058_00940	COG1320	monovalent cation:proton antiporter activity
EML4058_00945	COG2212	antiporter activity
EML4058_00950	COG1863	multisubunit Na H antiporter MnhE subunit
EML4058_00955	COG0651	ATP synthesis coupled electron transport
EML4058_00960	COG1006	Multisubunit Na H antiporter MnhC subunit
EML4058_00965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EML4058_00965	COG2111	Na H antiporter
EML4058_00975	COG0840	transmembrane signaling receptor activity
EML4058_00985	COG0745	RESPONSE REGULATOR receiver
EML4058_00990	COG2198	Histidine kinase
EML4058_00990	COG0643	Histidine kinase
EML4058_00995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EML4058_01000	COG2201	protein-glutamate methylesterase activity
EML4058_01005	COG0745	RESPONSE REGULATOR receiver
EML4058_01010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EML4058_01020	COG1766	The M ring may be actively involved in energy transduction
EML4058_01025	COG2771	luxR family
EML4058_01035	COG0840	transmembrane signaling receptor activity
EML4058_01035	COG2972	Histidine kinase
EML4058_01040	COG0784	Response regulator, receiver
EML4058_01040	COG2198	Histidine kinase
EML4058_01040	COG2205	protein histidine kinase activity
EML4058_01045	COG1970	mechanosensitive ion channel activity
EML4058_01050	COG0436	Aminotransferase
EML4058_01065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EML4058_01070	COG0424	maF-like protein
EML4058_01075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EML4058_01085	COG5328	Belongs to the UPF0262 family
EML4058_01090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EML4058_01100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EML4058_01115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EML4058_01135	COG1338	Plays a role in the flagellum-specific transport system
EML4058_01145	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EML4058_01155	COG1706	bacterial-type flagellum-dependent cell motility
EML4058_01160	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EML4058_01165	COG4786	Flagellar basal body rod
EML4058_01170	COG1677	Flagellar hook-basal body complex protein FliE
EML4058_01175	COG1558	bacterial-type flagellum-dependent cell motility
EML4058_01180	COG1815	bacterial-type flagellum-dependent cell motility
EML4058_01190	COG1157	protein secretion by the type III secretion system
EML4058_01195	COG4786	Flagellar basal body rod
EML4058_01205	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EML4058_01210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4058_01215	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4058_01220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EML4058_01225	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EML4058_01245	COG1360	Flagellar Motor Protein
EML4058_01270	COG1749	Flagellar hook protein flgE
EML4058_01290	COG5443	negative regulation of bacterial-type flagellum assembly
EML4058_01295	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EML4058_01305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EML4058_01345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EML4058_01350	COG1609	Transcriptional regulator
EML4058_01355	COG1653	transport
EML4058_01360	COG1175	transmembrane transport
EML4058_01365	COG0395	ABC-type sugar transport system, permease component
EML4058_01370	COG0366	Alpha amylase catalytic
EML4058_01375	COG3842	ATPase activity
EML4058_01390	COG0129	dihydroxy-acid dehydratase activity
EML4058_01395	COG0363	glucosamine-6-phosphate deaminase activity
EML4058_01400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EML4058_01405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_01415	COG2081	HI0933 family
EML4058_01430	COG2224	Isocitrate lyase
EML4058_01445	COG3842	ATPase activity
EML4058_01450	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_01455	COG1177	transmembrane transport
EML4058_01465	COG2205	protein histidine kinase activity
EML4058_01475	COG0248	Ppx GppA phosphatase
EML4058_01480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EML4058_01485	COG0477	Major facilitator Superfamily
EML4058_01530	COG0521	Mo-molybdopterin cofactor biosynthetic process
EML4058_01535	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EML4058_01545	COG0142	geranyltranstransferase activity
EML4058_01570	COG0752	glycyl-tRNA synthetase alpha subunit
EML4058_01580	COG1704	LemA family
EML4058_01585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EML4058_01595	COG0751	glycine-tRNA ligase activity
EML4058_01600	COG1683	Conserved Protein
EML4058_01605	COG0840	transmembrane signaling receptor activity
EML4058_01615	COG0151	Belongs to the GarS family
EML4058_01620	COG2183	response to ionizing radiation
EML4058_01625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4058_01635	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EML4058_01650	COG0583	DNA-binding transcription factor activity
EML4058_01670	COG0306	phosphate transporter
EML4058_01680	COG0561	phosphatase activity
EML4058_01685	COG0438	transferase activity, transferring glycosyl groups
EML4058_01690	COG2186	Transcriptional regulator
EML4058_01700	COG0583	DNA-binding transcription factor activity
EML4058_01705	COG0277	FAD linked oxidase domain protein
EML4058_01710	COG0277	FAD linked oxidase domain protein
EML4058_01715	COG0247	lactate metabolic process
EML4058_01725	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_01730	COG0519	Catalyzes the synthesis of GMP from XMP
EML4058_01740	COG2855	membrane
EML4058_01745	COG0583	DNA-binding transcription factor activity
EML4058_01765	COG0124	histidyl-tRNA synthetase
EML4058_01775	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EML4058_01780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EML4058_01785	COG2259	Doxx family
EML4058_01795	COG0459	protein refolding
EML4058_01800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EML4058_01810	COG0196	riboflavin kinase activity
EML4058_01815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EML4058_01825	COG0590	tRNA wobble adenosine to inosine editing
EML4058_01830	COG1187	pseudouridine synthase activity
EML4058_01835	COG0742	ribosomal rna small subunit methyltransferase
EML4058_01840	COG1752	Esterase of the alpha-beta hydrolase superfamily
EML4058_01850	COG0312	modulator of DNA gyrase
EML4058_01855	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_01875	COG1663	tetraacyldisaccharide 4'-kinase activity
EML4058_01885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EML4058_01895	COG5001	Diguanylate cyclase
EML4058_01895	COG3300	MHYT domain
EML4058_01900	COG3386	PFAM SMP-30 Gluconolaconase
EML4058_01905	COG0800	Aldolase
EML4058_01910	COG3734	2-keto-3-deoxy-galactonokinase
EML4058_01915	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_01925	COG2197	response regulator
EML4058_01930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4058_01940	COG0598	Magnesium transport protein CorA
EML4058_01945	COG3158	transport of potassium into the cell
EML4058_01960	COG0356	it plays a direct role in the translocation of protons across the membrane
EML4058_01970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EML4058_01975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EML4058_01990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EML4058_02010	COG0009	L-threonylcarbamoyladenylate synthase
EML4058_02020	COG4638	Rieske (2fe-2S)
EML4058_02045	COG1960	acyl-CoA dehydrogenase activity
EML4058_02060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EML4058_02065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EML4058_02070	COG0840	transmembrane signaling receptor activity
EML4058_02110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EML4058_02115	COG1741	Belongs to the pirin family
EML4058_02120	COG1722	exodeoxyribonuclease VII activity
EML4058_02125	COG0123	including yeast histone deacetylase and acetoin utilization protein
EML4058_02130	COG1268	BioY protein
EML4058_02135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EML4058_02140	COG1122	ATPase activity
EML4058_02145	COG3214	Protein conserved in bacteria
EML4058_02150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4058_02150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4058_02155	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EML4058_02175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EML4058_02190	COG0259	pyridoxamine-phosphate oxidase activity
EML4058_02205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4058_02215	COG0312	modulator of DNA gyrase
EML4058_02230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4058_02235	COG0109	protoheme IX farnesyltransferase activity
EML4058_02240	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EML4058_02255	COG3346	SURF1 family
EML4058_02260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EML4058_02265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EML4058_02270	COG0328	RNA-DNA hybrid ribonuclease activity
EML4058_02285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EML4058_02285	COG0678	peroxiredoxin activity
EML4058_02295	COG1678	Uncharacterized ACR, COG1678
EML4058_02315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EML4058_02320	COG0612	Peptidase, M16
EML4058_02335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4058_02340	COG1802	Transcriptional regulator
EML4058_02355	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EML4058_02370	COG1194	a g-specific adenine glycosylase
EML4058_02380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EML4058_02385	COG1196	nuclear chromosome segregation
EML4058_02390	COG2514	catechol 2,3-dioxygenase activity
EML4058_02395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EML4058_02395	COG0574	Belongs to the PEP-utilizing enzyme family
EML4058_02410	COG1823	symporter activity
EML4058_02440	COG0579	oxidoreductase
EML4058_02455	COG2895	sulfate adenylyltransferase (ATP) activity
EML4058_02460	COG0175	sulfate reduction
EML4058_02465	COG0175	sulfate reduction
EML4058_02470	COG1959	2 iron, 2 sulfur cluster binding
EML4058_02475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EML4058_02480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EML4058_02485	COG4208	sulfate ABC transporter
EML4058_02490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EML4058_02500	COG2200	EAL domain
EML4058_02500	COG2203	Gaf domain
EML4058_02500	COG2199	diguanylate cyclase activity
EML4058_02510	COG1309	transcriptional regulator
EML4058_02515	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_02520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EML4058_02565	COG0477	Major facilitator Superfamily
EML4058_02575	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EML4058_02575	COG1793	dna ligase
EML4058_02595	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_02600	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_02605	COG1846	Transcriptional regulator
EML4058_02610	COG1764	response to oxidative stress
EML4058_02625	COG0488	(ABC) transporter
EML4058_02660	COG4221	oxidoreductase activity
EML4058_02675	COG0433	COG0433 Predicted ATPase
EML4058_02685	COG1733	regulation of RNA biosynthetic process
EML4058_02690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EML4058_02705	COG0656	L-ascorbic acid biosynthetic process
EML4058_02710	COG2378	regulation of single-species biofilm formation
EML4058_02720	COG4106	trans-aconitate 2-methyltransferase activity
EML4058_02725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4058_02730	COG0840	transmembrane signaling receptor activity
EML4058_02735	COG0583	DNA-binding transcription factor activity
EML4058_02750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EML4058_02760	COG2378	regulation of single-species biofilm formation
EML4058_02770	COG3909	cytochrome
EML4058_02775	COG2010	Cytochrome c
EML4058_02805	COG0789	Transcriptional regulator
EML4058_02830	COG0517	IMP dehydrogenase activity
EML4058_02830	COG4175	Glycine betaine
EML4058_02835	COG4176	ABC-type proline glycine betaine transport system permease component
EML4058_02860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_02870	COG2169	Transcriptional regulator
EML4058_02870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4058_02880	COG2514	catechol 2,3-dioxygenase activity
EML4058_02900	COG1272	protein, Hemolysin III
EML4058_02910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EML4058_02915	COG2111	Na H antiporter
EML4058_02915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EML4058_02920	COG2111	Na H antiporter
EML4058_02925	COG1006	Multisubunit Na H antiporter MnhC subunit
EML4058_02930	COG0651	ATP synthesis coupled electron transport
EML4058_02935	COG1863	multisubunit Na H antiporter MnhE subunit
EML4058_02940	COG2212	antiporter activity
EML4058_02945	COG1320	monovalent cation:proton antiporter activity
EML4058_02950	COG4957	zinc ion binding
EML4058_02965	COG2166	iron-sulfur cluster assembly
EML4058_02975	COG2205	protein histidine kinase activity
EML4058_03030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4058_03035	COG2983	Belongs to the UPF0260 family
EML4058_03045	COG3041	Addiction module toxin RelE StbE family
EML4058_03050	COG3077	Addiction module antitoxin, RelB DinJ family
EML4058_03080	COG2337	Toxic component of a toxin-antitoxin (TA) module
EML4058_03090	COG2814	Major facilitator Superfamily
EML4058_03100	COG1621	beta-fructofuranosidase activity
EML4058_03105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EML4058_03155	COG4695	Portal protein
EML4058_03270	COG4235	cytochrome complex assembly
EML4058_03275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EML4058_03280	COG1138	Cytochrome C-type biogenesis protein
EML4058_03285	COG3088	subunit of a heme lyase
EML4058_03290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4058_03300	COG2205	protein histidine kinase activity
EML4058_03305	COG3713	MltA-interacting MipA family protein
EML4058_03310	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EML4058_03315	COG2205	protein histidine kinase activity
EML4058_03315	COG2202	Pas domain
EML4058_03325	COG0308	aminopeptidase N
EML4058_03330	COG0697	spore germination
EML4058_03345	COG0443	Heat shock 70 kDa protein
EML4058_03385	COG0604	alcohol dehydrogenase
EML4058_03390	COG1733	regulation of RNA biosynthetic process
EML4058_03395	COG1968	undecaprenyl-diphosphatase activity
EML4058_03400	COG2239	Acts as a magnesium transporter
EML4058_03405	COG2814	Major facilitator Superfamily
EML4058_03435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EML4058_03465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EML4058_03515	COG0741	lytic transglycosylase activity
EML4058_03520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_03525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EML4058_03530	COG0840	transmembrane signaling receptor activity
EML4058_03540	COG1758	RNA polymerase activity
EML4058_03560	COG0736	holo-[acyl-carrier-protein] synthase activity
EML4058_03565	COG0681	Belongs to the peptidase S26 family
EML4058_03570	COG0571	ribonuclease III activity
EML4058_03575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EML4058_03580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EML4058_03585	COG0784	Response regulator, receiver
EML4058_03590	COG1381	Involved in DNA repair and RecF pathway recombination
EML4058_03600	COG2226	methyltransferase
EML4058_03610	COG1418	mRNA catabolic process
EML4058_03620	COG0346	lactoylglutathione lyase activity
EML4058_03635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_03640	COG3443	Belongs to the bacterial solute-binding protein 9 family
EML4058_03645	COG0668	transmembrane transport
EML4058_03655	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EML4058_03680	COG1051	belongs to the nudix hydrolase family
EML4058_03685	COG1742	UPF0060 membrane protein
EML4058_03700	COG1183	phosphatidylcholine synthase activity
EML4058_03705	COG0688	phosphatidylethanolamine metabolic process
EML4058_03710	COG5265	(ABC) transporter
EML4058_03715	COG1652	LysM domain
EML4058_03750	COG2852	Protein conserved in bacteria
EML4058_03755	COG0215	cysteine-tRNA ligase activity
EML4058_03760	COG4221	oxidoreductase activity
EML4058_03765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EML4058_03770	COG1286	toxin biosynthetic process
EML4058_03790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EML4058_03800	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EML4058_03810	COG0305	Participates in initiation and elongation during chromosome replication
EML4058_03830	COG0359	binds to the 23S rRNA
EML4058_03840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EML4058_03845	COG0360	Binds together with S18 to 16S ribosomal RNA
EML4058_03850	COG0667	Aldo Keto reductase
EML4058_03855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EML4058_03865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4058_03870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4058_03875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EML4058_03880	COG1561	YicC-like family, N-terminal region
EML4058_03885	COG0194	GDP metabolic process
EML4058_03890	COG0400	carboxylic ester hydrolase activity
EML4058_03895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EML4058_03900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EML4058_03910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EML4058_03925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EML4058_03945	COG5001	Diguanylate cyclase
EML4058_03945	COG3300	MHYT domain
EML4058_03950	COG4191	Histidine kinase
EML4058_03965	COG0488	(ABC) transporter
EML4058_03970	COG3706	GGDEF domain
EML4058_03980	COG0105	UTP biosynthetic process
EML4058_04000	COG0314	molybdopterin synthase activity
EML4058_04005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EML4058_04010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EML4058_04015	COG0322	excinuclease ABC activity
EML4058_04020	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_04030	COG0625	glutathione transferase activity
EML4058_04045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EML4058_04050	COG0243	molybdopterin cofactor binding
EML4058_04065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EML4058_04070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EML4058_04075	COG0628	permease
EML4058_04085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EML4058_04090	COG0248	Ppx GppA phosphatase
EML4058_04115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EML4058_04125	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EML4058_04130	COG0477	Major facilitator Superfamily
EML4058_04135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EML4058_04145	COG4452	Inner membrane protein CreD
EML4058_04150	COG0659	secondary active sulfate transmembrane transporter activity
EML4058_04160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EML4058_04165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EML4058_04175	COG0113	porphobilinogen synthase activity
EML4058_04195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EML4058_04200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EML4058_04205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EML4058_04205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EML4058_04215	COG1280	lysine exporter protein (LysE YggA)
EML4058_04220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EML4058_04225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EML4058_04230	COG2814	Major facilitator Superfamily
EML4058_04235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EML4058_04255	COG0416	fatty acid biosynthetic process
EML4058_04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EML4058_04265	COG0776	regulation of translation
EML4058_04360	COG0601	transmembrane transport
EML4058_04365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_04370	COG0444	Belongs to the ABC transporter superfamily
EML4058_04390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EML4058_04395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EML4058_04410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EML4058_04415	COG0583	DNA-binding transcription factor activity
EML4058_04420	COG0737	Belongs to the 5'-nucleotidase family
EML4058_04445	COG2897	thiosulfate sulfurtransferase activity
EML4058_04460	COG0415	Belongs to the DNA photolyase family
EML4058_04470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4058_04500	COG3932	Exopolysaccharide synthesis, ExoD
EML4058_04555	COG0297	glycogen (starch) synthase activity
EML4058_04580	COG1612	heme a metabolic process
EML4058_04590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EML4058_04595	COG0010	Belongs to the arginase family
EML4058_04600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EML4058_04605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EML4058_04615	COG1832	CoA-binding protein
EML4058_04640	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_04645	COG2124	cytochrome p450
EML4058_04650	COG2199	diguanylate cyclase activity
EML4058_04655	COG0740	serine-type endopeptidase activity
EML4058_04660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EML4058_04665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EML4058_04695	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4058_04700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4058_04705	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4058_04715	COG0649	NAD binding
EML4058_04725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
EML4058_04730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EML4058_04740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EML4058_04745	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EML4058_04755	COG0713	ATP synthesis coupled electron transport
EML4058_04770	COG1007	ATP synthesis coupled electron transport
EML4058_04790	COG0442	prolyl-tRNA aminoacylation
EML4058_04800	COG1136	(ABC) transporter
EML4058_04815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EML4058_04825	COG0784	Response regulator, receiver
EML4058_04835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EML4058_04840	COG0477	Major facilitator Superfamily
EML4058_04855	COG0557	exoribonuclease II activity
EML4058_04860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EML4058_04870	COG0758	DNA mediated transformation
EML4058_04875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EML4058_04885	COG0540	Belongs to the ATCase OTCase family
EML4058_04895	COG1960	acyl-CoA dehydrogenase activity
EML4058_04900	COG0456	acetyltransferase
EML4058_04930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EML4058_04935	COG2824	Alkylphosphonate utilization operon protein PhnA
EML4058_04940	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EML4058_04945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EML4058_04950	COG0154	amidase activity
EML4058_04955	COG0456	acetyltransferase
EML4058_04960	COG3811	Belongs to the UPF0386 family
EML4058_04975	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EML4058_04985	COG0456	acetyltransferase
EML4058_05000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EML4058_05005	COG0439	Biotin carboxylase
EML4058_05010	COG0511	ligase activity, forming carbon-carbon bonds
EML4058_05015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EML4058_05025	COG0436	Aminotransferase
EML4058_05045	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_05050	COG1530	ribonuclease E activity
EML4058_05065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4058_05085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EML4058_05090	COG0384	phenazine biosynthesis protein PhzF
EML4058_05110	COG0633	Ferredoxin
EML4058_05120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EML4058_05125	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EML4058_05130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EML4058_05140	COG3768	UPF0283 membrane protein
EML4058_05145	COG3106	COG3106 Predicted ATPase
EML4058_05175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EML4058_05205	COG0537	adenosine 5'-monophosphoramidase activity
EML4058_05230	COG0052	Belongs to the universal ribosomal protein uS2 family
EML4058_05235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EML4058_05240	COG0528	UMP kinase activity
EML4058_05245	COG0233	cytoplasmic translational termination
EML4058_05250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EML4058_05260	COG0750	zinc metalloprotease
EML4058_05265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EML4058_05270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4058_05275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4058_05280	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4058_05285	COG3494	Protein of unknown function (DUF1009)
EML4058_05290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EML4058_05295	COG2186	Transcriptional regulator
EML4058_05305	COG0765	amino acid transport
EML4058_05310	COG0765	amino acid transport
EML4058_05320	COG0372	Belongs to the citrate synthase family
EML4058_05335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EML4058_05340	COG4598	ABC transporter
EML4058_05345	COG0765	amino acid transport
EML4058_05350	COG0765	amino acid transport
EML4058_05355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_05360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_05370	COG0395	ABC-type sugar transport system, permease component
EML4058_05380	COG2182	Extracellular solute-binding protein
EML4058_05390	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_05395	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_05400	COG1063	alcohol dehydrogenase
EML4058_05405	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EML4058_05425	COG0683	leucine binding
EML4058_05430	COG1960	acyl-CoA dehydrogenase activity
EML4058_05445	COG1024	Enoyl-CoA hydratase
EML4058_05460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4058_05480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EML4058_05485	COG0148	phosphopyruvate hydratase activity
EML4058_05495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EML4058_05500	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4058_05500	COG0022	dehydrogenase e1 component
EML4058_05510	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4058_05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EML4058_05530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EML4058_05535	COG0697	spore germination
EML4058_05555	COG2867	negative regulation of translational initiation
EML4058_05565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EML4058_05565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EML4058_05575	COG3852	Histidine kinase
EML4058_05580	COG2204	response regulator
EML4058_05585	COG5000	phosphorelay sensor kinase activity
EML4058_05590	COG2204	response regulator
EML4058_05595	COG0569	domain protein
EML4058_05600	COG1923	regulation of RNA biosynthetic process
EML4058_05605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EML4058_05610	COG3956	TIGRFAM MazG family protein
EML4058_05620	COG1648	precorrin-2 dehydrogenase activity
EML4058_05620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EML4058_05635	COG0275	rRNA processing
EML4058_05660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EML4058_05660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EML4058_05665	COG0509	glycine decarboxylation via glycine cleavage system
EML4058_05670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4058_05695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EML4058_05720	COG0251	oxidation-reduction process
EML4058_05725	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EML4058_05735	COG1671	Belongs to the UPF0178 family
EML4058_05745	COG0450	alkyl hydroperoxide reductase
EML4058_05785	COG2826	transposase and inactivated derivatives, IS30 family
EML4058_05790	COG0431	NADPH-dependent FMN reductase
EML4058_05800	COG0798	PFAM Bile acid sodium symporter
EML4058_05820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EML4058_05820	COG0321	lipoyl(octanoyl) transferase activity
EML4058_05825	COG0084	hydrolase, TatD family'
EML4058_05830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4058_05840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EML4058_05895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EML4058_05900	COG2095	MarC family integral membrane protein
EML4058_05905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EML4058_05905	COG0617	tRNA 3'-terminal CCA addition
EML4058_05905	COG0517	IMP dehydrogenase activity
EML4058_05915	COG3609	addiction module antidote protein, CC2985 family
EML4058_05920	COG0629	single-stranded DNA binding
EML4058_05925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EML4058_05935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EML4058_05940	COG0179	Fumarylacetoacetate (FAA) hydrolase
EML4058_05955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4058_05960	COG1121	(ABC) transporter
EML4058_05980	COG0667	Aldo Keto reductase
EML4058_05990	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EML4058_06060	COG0668	transmembrane transport
EML4058_06085	COG2239	Acts as a magnesium transporter
EML4058_06090	COG0243	molybdopterin cofactor binding
EML4058_06100	COG0242	peptide deformylase activity
EML4058_06125	COG0321	lipoyl(octanoyl) transferase activity
EML4058_06130	COG1064	alcohol dehydrogenase
EML4058_06160	COG1862	Preprotein translocase
EML4058_06185	COG2124	cytochrome p450
EML4058_06200	COG0596	Alpha beta hydrolase
EML4058_06215	COG0626	cystathionine gamma-synthase activity
EML4058_06220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_06225	COG4597	amino acid ABC transporter
EML4058_06230	COG0765	amino acid transport
EML4058_06235	COG1126	abc transporter atp-binding protein
EML4058_06250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EML4058_06265	COG0436	Aminotransferase
EML4058_06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4058_06305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4058_06310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4058_06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EML4058_06330	COG3243	poly(R)-hydroxyalkanoic acid synthase
EML4058_06335	COG1489	DNA binding
EML4058_06340	COG0024	Methionine aminopeptidase
EML4058_06345	COG2003	Belongs to the UPF0758 family
EML4058_06360	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EML4058_06375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EML4058_06380	COG0546	phosphoglycolate phosphatase activity
EML4058_06390	COG0114	fumarate hydratase activity
EML4058_06400	COG0504	CTP synthase activity
EML4058_06410	COG0149	triose-phosphate isomerase activity
EML4058_06420	COG0187	DNA topoisomerase II activity
EML4058_06430	COG1309	transcriptional regulator
EML4058_06435	COG2226	methyltransferase
EML4058_06445	COG0740	serine-type endopeptidase activity
EML4058_06455	COG0640	Transcriptional regulator
EML4058_06460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EML4058_06465	COG0745	RESPONSE REGULATOR receiver
EML4058_06475	COG3264	Mechanosensitive ion channel
EML4058_06475	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EML4058_06535	COG1127	ABC transporter
EML4058_06540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EML4058_06545	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_06560	COG0281	malic enzyme
EML4058_06560	COG0280	phosphate acetyltransferase
EML4058_06570	COG0778	Nitroreductase
EML4058_06575	COG0823	Involved in the tonB-independent uptake of proteins
EML4058_06585	COG1368	sulfuric ester hydrolase activity
EML4058_06610	COG0544	peptidyl-prolyl cis-trans isomerase activity
EML4058_06630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EML4058_06635	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EML4058_06675	COG0343	queuine tRNA-ribosyltransferase activity
EML4058_06680	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EML4058_06695	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EML4058_06710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EML4058_06715	COG0134	indole-3-glycerol-phosphate synthase activity
EML4058_06720	COG0315	cyclic pyranopterin monophosphate synthase activity
EML4058_06725	COG0303	'Molybdopterin
EML4058_06730	COG3706	GGDEF domain
EML4058_06740	COG0475	glutathione-regulated potassium exporter activity
EML4058_06740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EML4058_06750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EML4058_06755	COG0697	spore germination
EML4058_06760	COG2814	Major facilitator Superfamily
EML4058_06765	COG0746	molybdenum cofactor guanylyltransferase activity
EML4058_06770	COG1763	Mo-molybdopterin cofactor biosynthetic process
EML4058_06775	COG0739	heme binding
EML4058_06780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EML4058_06785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EML4058_06790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EML4058_06795	COG0805	protein transport
EML4058_06800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EML4058_06805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EML4058_06810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EML4058_06815	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EML4058_06820	COG1472	Belongs to the glycosyl hydrolase 3 family
EML4058_06830	COG0018	arginyl-trna synthetase
EML4058_06835	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EML4058_06840	COG0316	Belongs to the HesB IscA family
EML4058_06850	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EML4058_06865	COG0525	valine-tRNA ligase activity
EML4058_06875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EML4058_06905	COG0655	NAD(P)H dehydrogenase (quinone) activity
EML4058_06910	COG1058	Belongs to the CinA family
EML4058_06910	COG1546	Belongs to the CinA family
EML4058_06915	COG0589	response to stress
EML4058_06920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EML4058_06925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EML4058_06940	COG1914	H( )-stimulated, divalent metal cation uptake system
EML4058_06950	COG1132	(ABC) transporter
EML4058_06955	COG0628	permease
EML4058_06975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4058_06990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EML4058_07000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EML4058_07010	COG0302	gtp cyclohydrolase
EML4058_07015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EML4058_07020	COG1752	Esterase of the alpha-beta hydrolase superfamily
EML4058_07025	COG0517	IMP dehydrogenase activity
EML4058_07025	COG0516	GMP reductase activity
EML4058_07055	COG1760	l-serine dehydratase
EML4058_07090	COG0583	DNA-binding transcription factor activity
EML4058_07100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EML4058_07100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EML4058_07105	COG0347	Belongs to the P(II) protein family
EML4058_07110	COG0174	glutamine synthetase
EML4058_07140	COG0697	spore germination
EML4058_07150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EML4058_07160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EML4058_07170	COG3668	Plasmid stabilization system
EML4058_07175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EML4058_07190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EML4058_07195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EML4058_07200	COG2186	Transcriptional regulator
EML4058_07210	COG1079	Belongs to the binding-protein-dependent transport system permease family
EML4058_07215	COG4603	Belongs to the binding-protein-dependent transport system permease family
EML4058_07220	COG3845	ABC transporter
EML4058_07225	COG1183	phosphatidylcholine synthase activity
EML4058_07230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4058_07235	COG0679	Auxin Efflux Carrier
EML4058_07240	COG0785	Cytochrome C biogenesis protein
EML4058_07270	COG1278	Cold shock
EML4058_07325	COG2267	carboxylic ester hydrolase activity
EML4058_07340	COG1136	(ABC) transporter
EML4058_07340	COG0577	efflux transmembrane transporter activity
EML4058_07345	COG1136	(ABC) transporter
EML4058_07345	COG0577	efflux transmembrane transporter activity
EML4058_07360	COG2151	metal-sulfur cluster biosynthetic enzyme
EML4058_07365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EML4058_07370	COG0719	Fe-S assembly protein
EML4058_07375	COG0396	ATPase activity
EML4058_07380	COG0719	Fe-S assembly protein
EML4058_07385	COG1104	cysteine desulfurase activity
EML4058_07390	COG2945	thiolester hydrolase activity
EML4058_07395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EML4058_07400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EML4058_07410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EML4058_07415	COG2833	Protein of unknown function (DUF455)
EML4058_07420	COG0739	heme binding
EML4058_07425	COG0513	Belongs to the DEAD box helicase family
EML4058_07455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EML4058_07465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EML4058_07470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EML4058_07475	COG0047	phosphoribosylformylglycinamidine synthase activity
EML4058_07490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4058_07500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EML4058_07520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EML4058_07525	COG2814	Major facilitator Superfamily
EML4058_07530	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_07535	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_07540	COG0037	tRNA processing
EML4058_07545	COG2066	Belongs to the glutaminase family
EML4058_07550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EML4058_07555	COG0861	Integral membrane protein TerC family
EML4058_07570	COG1280	lysine exporter protein (LysE YggA)
EML4058_07580	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EML4058_07585	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EML4058_07595	COG0538	isocitrate dehydrogenase activity
EML4058_07610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EML4058_07615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EML4058_07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_07625	COG2313	pseudouridylate synthase activity
EML4058_07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_07640	COG4215	(ABC) transporter
EML4058_07650	COG5425	PFAM Usg family protein
EML4058_07660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4058_07665	COG1522	sequence-specific DNA binding
EML4058_07670	COG1573	uracil-dna glycosylase
EML4058_07680	COG2202	Pas domain
EML4058_07680	COG2205	protein histidine kinase activity
EML4058_07690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EML4058_07695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EML4058_07710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EML4058_07715	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_07720	COG1129	ABC transporter
EML4058_07730	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_07735	COG3959	Transketolase, thiamine diphosphate binding domain
EML4058_07740	COG3958	Transketolase
EML4058_07745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EML4058_07750	COG2390	Transcriptional regulator
EML4058_07760	COG0842	Transport permease protein
EML4058_07765	COG1131	(ABC) transporter
EML4058_07790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EML4058_07795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EML4058_07810	COG0129	dihydroxy-acid dehydratase activity
EML4058_07815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EML4058_07820	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EML4058_07830	COG3739	integral membrane protein
EML4058_07835	COG0203	ribosomal protein L17
EML4058_07840	COG0202	RNA polymerase activity
EML4058_07845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EML4058_07850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EML4058_07855	COG0563	adenylate kinase activity
EML4058_07860	COG0201	protein transport
EML4058_07865	COG0200	Binds to the 23S rRNA
EML4058_07870	COG1841	ribosomal large subunit assembly
EML4058_07875	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EML4058_07880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EML4058_07885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EML4058_07890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EML4058_07895	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EML4058_07900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EML4058_07905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EML4058_07910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EML4058_07915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EML4058_07920	COG0255	Belongs to the universal ribosomal protein uL29 family
EML4058_07925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EML4058_07930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EML4058_07935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EML4058_07940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EML4058_07945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EML4058_07950	COG0089	rRNA binding
EML4058_07955	COG0088	Forms part of the polypeptide exit tunnel
EML4058_07960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EML4058_07965	COG0051	transcription antitermination factor activity, RNA binding
EML4058_07970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EML4058_07975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EML4058_07980	COG0049	tRNA binding
EML4058_07985	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EML4058_08005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EML4058_08010	COG0085	RNA polymerase activity
EML4058_08015	COG0222	ribosome binding
EML4058_08020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EML4058_08025	COG0081	regulation of translation
EML4058_08030	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EML4058_08040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EML4058_08050	COG1086	Polysaccharide biosynthesis protein
EML4058_08055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EML4058_08060	COG0861	Integral membrane protein TerC family
EML4058_08065	COG3895	Periplasmic Protein
EML4058_08085	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4058_08105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EML4058_08140	COG2198	Histidine kinase
EML4058_08140	COG2205	protein histidine kinase activity
EML4058_08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_08140	COG0784	Response regulator, receiver
EML4058_08145	COG0784	Response regulator, receiver
EML4058_08150	COG2202	Pas domain
EML4058_08150	COG3920	Histidine kinase
EML4058_08155	COG0784	Response regulator, receiver
EML4058_08160	COG4251	negative regulation of phosphorylation
EML4058_08175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EML4058_08205	COG2910	NAD(P)H-binding
EML4058_08210	COG1733	regulation of RNA biosynthetic process
EML4058_08215	COG0556	nucleotide-excision repair
EML4058_08220	COG2382	esterase
EML4058_08240	COG0484	heat shock protein binding
EML4058_08255	COG3706	GGDEF domain
EML4058_08265	COG3842	ATPase activity
EML4058_08275	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4058_08280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4058_08290	COG4115	mRNA cleavage
EML4058_08300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EML4058_08310	COG2207	Transcriptional regulator
EML4058_08315	COG1064	alcohol dehydrogenase
EML4058_08320	COG1252	NADH dehydrogenase
EML4058_08325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EML4058_08330	COG2197	response regulator
EML4058_08335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EML4058_08365	COG0656	L-ascorbic acid biosynthetic process
EML4058_08380	COG0440	acetolactate synthase activity
EML4058_08385	COG0028	Belongs to the TPP enzyme family
EML4058_08395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EML4058_08400	COG3830	Belongs to the UPF0237 family
EML4058_08400	COG0560	Phosphoserine phosphatase
EML4058_08410	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_08420	COG0330	HflC and HflK could
EML4058_08425	COG0330	HflC and HflK could
EML4058_08435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EML4058_08470	COG0277	FAD linked oxidase domain protein
EML4058_08475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4058_08530	COG1335	isochorismatase
EML4058_08550	COG0006	proline dipeptidase activity
EML4058_08560	COG2264	protein methyltransferase activity
EML4058_08565	COG1999	signal sequence binding
EML4058_08575	COG0835	chemotaxis
EML4058_08585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EML4058_08590	COG0583	DNA-binding transcription factor activity
EML4058_08600	COG1247	-acetyltransferase
EML4058_08610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EML4058_08615	COG0497	DNA recombination
EML4058_08620	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EML4058_08630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EML4058_08635	COG0849	cell division
EML4058_08640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EML4058_08645	COG1181	Belongs to the D-alanine--D-alanine ligase family
EML4058_08650	COG0477	Major facilitator Superfamily
EML4058_08655	COG5001	Diguanylate cyclase
EML4058_08655	COG3300	MHYT domain
EML4058_08660	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EML4058_08665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EML4058_08670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EML4058_08680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EML4058_08685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EML4058_08695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EML4058_08710	COG0275	rRNA processing
EML4058_08715	COG2001	Belongs to the MraZ family
EML4058_08720	COG3766	membrane
EML4058_08765	COG3023	N-Acetylmuramoyl-L-alanine amidase
EML4058_08795	COG4106	trans-aconitate 2-methyltransferase activity
EML4058_08815	COG2226	methyltransferase
EML4058_08825	COG2267	carboxylic ester hydrolase activity
EML4058_08830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EML4058_08845	COG0251	oxidation-reduction process
EML4058_08860	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_08865	COG2814	Major facilitator Superfamily
EML4058_08890	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_08905	COG0174	glutamine synthetase
EML4058_08910	COG0531	amino acid
EML4058_08920	COG1737	Transcriptional regulator
EML4058_08940	COG3842	ATPase activity
EML4058_09000	COG2968	Membrane
EML4058_09010	COG0432	Pfam Uncharacterised protein family UPF0047
EML4058_09025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EML4058_09030	COG0358	DNA primase activity
EML4058_09040	COG0505	Belongs to the CarA family
EML4058_09055	COG0534	Mate efflux family protein
EML4058_09070	COG2321	neutral zinc metallopeptidase
EML4058_09085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EML4058_09095	COG3706	GGDEF domain
EML4058_09110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EML4058_09120	COG1522	sequence-specific DNA binding
EML4058_09125	COG0492	ferredoxin-NADP+ reductase activity
EML4058_09130	COG0583	DNA-binding transcription factor activity
EML4058_09140	COG1902	pentaerythritol trinitrate reductase activity
EML4058_09165	COG0387	Pfam Sodium calcium exchanger
EML4058_09170	COG0436	Aminotransferase
EML4058_09175	COG2200	EAL domain
EML4058_09175	COG2199	diguanylate cyclase activity
EML4058_09190	COG1278	Cold shock
EML4058_09195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4058_09205	COG1846	Transcriptional regulator
EML4058_09210	COG0745	RESPONSE REGULATOR receiver
EML4058_09215	COG2205	protein histidine kinase activity
EML4058_09220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4058_09240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EML4058_09250	COG1496	oxidoreductase activity
EML4058_09265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EML4058_09275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EML4058_09290	COG0840	transmembrane signaling receptor activity
EML4058_09295	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_09300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EML4058_09305	COG3300	MHYT domain
EML4058_09305	COG5001	Diguanylate cyclase
EML4058_09310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EML4058_09315	COG5001	Diguanylate cyclase
EML4058_09325	COG0193	aminoacyl-tRNA hydrolase activity
EML4058_09335	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EML4058_09355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EML4058_09360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EML4058_09360	COG2857	Cytochrome c1
EML4058_09380	COG1132	(ABC) transporter
EML4058_09385	COG1132	(ABC) transporter
EML4058_09390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EML4058_09395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EML4058_09410	COG0408	coproporphyrinogen oxidase activity
EML4058_09425	COG0617	tRNA 3'-terminal CCA addition
EML4058_09430	COG0494	nUDIX hydrolase
EML4058_09440	COG0714	Associated with various cellular activities
EML4058_09460	COG0454	-acetyltransferase
EML4058_09465	COG0477	Major facilitator Superfamily
EML4058_09475	COG0435	Glutathione S-transferase
EML4058_09480	COG0494	nUDIX hydrolase
EML4058_09490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EML4058_09495	COG3135	benzoate transporter
EML4058_09510	COG1595	DNA-templated transcription, initiation
EML4058_09520	COG0740	serine-type endopeptidase activity
EML4058_09535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EML4058_09540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EML4058_09565	COG4175	Glycine betaine
EML4058_09580	COG1435	thymidine kinase activity
EML4058_09600	COG2862	Uncharacterized protein family, UPF0114
EML4058_09615	COG0512	Glutamine amidotransferase of anthranilate synthase
EML4058_09615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EML4058_09630	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EML4058_09645	COG0366	Alpha amylase catalytic
EML4058_09650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_09670	COG1160	GTP binding
EML4058_09690	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EML4058_09700	COG0024	Methionine aminopeptidase
EML4058_09710	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_09720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EML4058_09730	COG0583	DNA-binding transcription factor activity
EML4058_09745	COG0402	S-adenosylhomocysteine deaminase activity
EML4058_09760	COG1304	FMN binding
EML4058_09770	COG1309	transcriptional regulator
EML4058_09775	COG1686	Belongs to the peptidase S11 family
EML4058_09785	COG2351	hydroxyisourate hydrolase activity
EML4058_09790	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EML4058_09815	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4058_09825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EML4058_09825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_09835	COG0513	Belongs to the DEAD box helicase family
EML4058_09840	COG0697	spore germination
EML4058_09845	COG2259	Doxx family
EML4058_09850	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_09860	COG2308	Evidence 4 Homologs of previously reported genes of
EML4058_09870	COG1305	Transglutaminase-like
EML4058_09875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4058_09885	COG0456	acetyltransferase
EML4058_09900	COG4214	carbohydrate transport
EML4058_09905	COG1129	ABC transporter
EML4058_09910	COG4213	ABC transporter substrate-binding protein
EML4058_09945	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EML4058_09955	COG0840	transmembrane signaling receptor activity
EML4058_09960	COG2814	Major facilitator Superfamily
EML4058_09965	COG0646	methionine synthase
EML4058_09965	COG1410	methionine synthase
EML4058_09975	COG4215	(ABC) transporter
EML4058_09980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_10005	COG1215	transferase activity, transferring glycosyl groups
EML4058_10035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EML4058_10040	COG2346	COG2346, Truncated hemoglobins
EML4058_10060	COG1309	transcriptional regulator
EML4058_10075	COG0494	nUDIX hydrolase
EML4058_10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_10090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_10120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EML4058_10125	COG0830	nickel cation binding
EML4058_10130	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EML4058_10145	COG0804	urea catabolic process
EML4058_10150	COG1442	glycosyl transferase family 8
EML4058_10155	COG3755	Protein conserved in bacteria
EML4058_10165	COG0832	Belongs to the urease beta subunit family
EML4058_10170	COG3813	Protein conserved in bacteria
EML4058_10175	COG0831	urea catabolic process
EML4058_10180	COG0829	nickel cation binding
EML4058_10205	COG0559	Belongs to the binding-protein-dependent transport system permease family
EML4058_10220	COG0174	glutamine synthetase
EML4058_10225	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_10230	COG2198	Histidine kinase
EML4058_10230	COG5002	protein histidine kinase activity
EML4058_10230	COG0784	Response regulator, receiver
EML4058_10280	COG1218	3'(2'),5'-bisphosphate nucleotidase
EML4058_10355	COG0564	pseudouridine synthase activity
EML4058_10365	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EML4058_10375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EML4058_10400	COG0346	lactoylglutathione lyase activity
EML4058_10410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EML4058_10420	COG2832	Protein of unknown function (DUF454)
EML4058_10425	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EML4058_10430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_10435	COG4558	Periplasmic binding protein
EML4058_10445	COG3721	Heme iron utilization protein
EML4058_10460	COG2205	protein histidine kinase activity
EML4058_10500	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_10505	COG4605	iron ion homeostasis
EML4058_10510	COG4604	ABC transporter, ATP-binding protein
EML4058_10515	COG0783	Belongs to the Dps family
EML4058_10530	COG0583	DNA-binding transcription factor activity
EML4058_10535	COG0657	acetylesterase activity
EML4058_10540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_10560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EML4058_10565	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EML4058_10570	COG0288	reversible hydration of carbon dioxide
EML4058_10580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EML4058_10595	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EML4058_10600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4058_10605	COG0778	Nitroreductase
EML4058_10610	COG2267	carboxylic ester hydrolase activity
EML4058_10615	COG0251	oxidation-reduction process
EML4058_10620	COG1335	isochorismatase
EML4058_10625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_10635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_10650	COG1175	transmembrane transport
EML4058_10655	COG0395	ABC-type sugar transport system, permease component
EML4058_10660	COG3842	ATPase activity
EML4058_10665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_10675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4058_10690	COG4608	Belongs to the ABC transporter superfamily
EML4058_10695	COG0444	Belongs to the ABC transporter superfamily
EML4058_10700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_10705	COG0601	transmembrane transport
EML4058_10725	COG0392	lysyltransferase activity
EML4058_10725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EML4058_10770	COG1960	acyl-CoA dehydrogenase activity
EML4058_10800	COG0745	RESPONSE REGULATOR receiver
EML4058_10810	COG1902	pentaerythritol trinitrate reductase activity
EML4058_10810	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4058_10845	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EML4058_10855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_10860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4058_10870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EML4058_10880	COG1509	lysine 2,3-aminomutase activity
EML4058_10895	COG0583	DNA-binding transcription factor activity
EML4058_10900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_10905	COG0725	ABC transporter, periplasmic molybdate-binding protein
EML4058_10910	COG4149	molybdate abc transporter
EML4058_10915	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EML4058_10925	COG3191	aminopeptidase activity
EML4058_10930	COG2022	thiamine diphosphate biosynthetic process
EML4058_10945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EML4058_10950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EML4058_10960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EML4058_10985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EML4058_11010	COG0438	transferase activity, transferring glycosyl groups
EML4058_11030	COG4166	transmembrane transport
EML4058_11035	COG0601	transmembrane transport
EML4058_11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_11050	COG0438	transferase activity, transferring glycosyl groups
EML4058_11055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EML4058_11060	COG3142	Participates in the control of copper homeostasis
EML4058_11080	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_11085	COG1737	Transcriptional regulator
EML4058_11095	COG3842	ATPase activity
EML4058_11105	COG0395	ABC-type sugar transport system, permease component
EML4058_11110	COG1175	transmembrane transport
EML4058_11120	COG2188	Transcriptional regulator
EML4058_11125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EML4058_11130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EML4058_11135	COG1940	carbohydrate kinase activity
EML4058_11145	COG0671	phosphoesterase, PA-phosphatase related
EML4058_11150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EML4058_11155	COG0156	8-amino-7-oxononanoate synthase activity
EML4058_11165	COG0729	surface antigen
EML4058_11175	COG0835	chemotaxis
EML4058_11185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EML4058_11190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EML4058_11195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EML4058_11200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EML4058_11205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EML4058_11210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EML4058_11225	COG4974	Belongs to the 'phage' integrase family
EML4058_11250	COG1280	lysine exporter protein (LysE YggA)
EML4058_11260	COG0508	dehydrogenase complex catalyzes the overall conversion of
EML4058_11270	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EML4058_11275	COG0045	succinate-CoA ligase (ADP-forming) activity
EML4058_11280	COG0039	L-malate dehydrogenase activity
EML4058_11285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EML4058_11320	COG2264	protein methyltransferase activity
EML4058_11335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EML4058_11340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EML4058_11345	COG0181	hydroxymethylbilane synthase activity
EML4058_11385	COG1872	DUF167
EML4058_11390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EML4058_11400	COG1217	gtp-binding protein TYPA
EML4058_11405	COG0339	signal peptide processing
EML4058_11410	COG1846	Transcriptional regulator
EML4058_11420	COG0137	argininosuccinate synthase activity
EML4058_11430	COG1280	lysine exporter protein (LysE YggA)
EML4058_11435	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EML4058_11440	COG4120	Belongs to the binding-protein-dependent transport system permease family
EML4058_11450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EML4058_11465	COG2154	pterin-4-alpha-carbinolamine dehydratase
EML4058_11470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EML4058_11475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EML4058_11485	COG4181	ATPase activity
EML4058_11495	COG0670	Belongs to the BI1 family
EML4058_11510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EML4058_11515	COG4133	protoheme IX ABC transporter activity
EML4058_11520	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EML4058_11525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EML4058_11550	COG2917	probably involved in intracellular septation
EML4058_11555	COG0552	protein localization to endoplasmic reticulum
EML4058_11560	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EML4058_11565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EML4058_11575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EML4058_11580	COG0287	Prephenate dehydrogenase
EML4058_11580	COG1605	Chorismate mutase
EML4058_11585	COG0228	four-way junction DNA binding
EML4058_11590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EML4058_11595	COG0336	Belongs to the RNA methyltransferase TrmD family
EML4058_11605	COG0335	large ribosomal subunit rRNA binding
EML4058_11610	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EML4058_11615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_11630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EML4058_11640	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EML4058_11660	COG0488	(ABC) transporter
EML4058_11670	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EML4058_11680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EML4058_11685	COG0142	geranyltranstransferase activity
EML4058_11690	COG2885	chlorophyll binding
EML4058_11695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EML4058_11700	COG2223	nitrite transmembrane transporter activity
EML4058_11705	COG1349	DNA-binding transcription factor activity
EML4058_11710	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EML4058_11715	COG2197	response regulator
EML4058_11720	COG1132	(ABC) transporter
EML4058_11730	COG3459	Glycosyltransferase 36 associated
EML4058_11735	COG1473	amidohydrolase
EML4058_11740	COG0579	oxidoreductase
EML4058_11750	COG0129	dihydroxy-acid dehydratase activity
EML4058_11755	COG2084	Dehydrogenase
EML4058_11760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_11765	COG0277	FAD linked oxidase domain protein
EML4058_11770	COG2186	Transcriptional regulator
EML4058_11780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EML4058_11785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_11790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_11795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EML4058_11805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EML4058_11810	COG0495	leucyl-tRNA aminoacylation
EML4058_11825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EML4058_11840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EML4058_11845	COG1946	Acyl-CoA thioesterase
EML4058_11850	COG0347	Belongs to the P(II) protein family
EML4058_11855	COG0004	ammonium transporteR
EML4058_11860	COG1674	ftsk spoiiie
EML4058_11865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EML4058_11880	COG0745	RESPONSE REGULATOR receiver
EML4058_11890	COG1329	Transcriptional regulator
EML4058_11895	COG2902	Dehydrogenase
EML4058_11900	COG2270	Major facilitator Superfamily
EML4058_11915	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_11930	COG0494	nUDIX hydrolase
EML4058_11940	COG0793	Belongs to the peptidase S41A family
EML4058_11950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EML4058_11955	COG0799	negative regulation of ribosome biogenesis
EML4058_11960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EML4058_11965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EML4058_11970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EML4058_11975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EML4058_11990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EML4058_11995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EML4058_12020	COG0066	3-isopropylmalate dehydratase activity
EML4058_12025	COG0473	3-isopropylmalate dehydrogenase activity
EML4058_12030	COG1858	cytochrome C peroxidase
EML4058_12035	COG1797	cobyrinic acid a,c-diamide synthase activity
EML4058_12040	COG1648	precorrin-2 dehydrogenase activity
EML4058_12040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EML4058_12045	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
EML4058_12110	COG1492	cobalamin metabolic process
EML4058_12125	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_12130	COG3254	rhamnose metabolic process
EML4058_12135	COG0246	Mannitol dehydrogenase
EML4058_12140	COG1063	alcohol dehydrogenase
EML4058_12160	COG4214	carbohydrate transport
EML4058_12165	COG1129	ABC transporter
EML4058_12170	COG2186	Transcriptional regulator
EML4058_12175	COG2721	sulfolactate sulfo-lyase activity
EML4058_12180	COG0138	bifunctional purine biosynthesis protein purh
EML4058_12190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EML4058_12190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EML4058_12195	COG0501	Belongs to the peptidase M48B family
EML4058_12215	COG0357	Ribosomal RNA small subunit methyltransferase G
EML4058_12220	COG0445	tRNA wobble uridine modification
EML4058_12225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EML4058_12230	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EML4058_12235	COG1981	membrane
EML4058_12240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EML4058_12245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EML4058_12250	COG0424	maF-like protein
EML4058_12255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EML4058_12260	COG0237	dephospho-CoA kinase activity
EML4058_12270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EML4058_12275	COG3030	protein affecting phage T7 exclusion by the F plasmid
EML4058_12285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EML4058_12310	COG0179	Fumarylacetoacetate (FAA) hydrolase
EML4058_12325	COG0135	phosphoribosylanthranilate isomerase activity
EML4058_12330	COG0133	tryptophan synthase activity
EML4058_12335	COG0159	tryptophan synthase activity
EML4058_12340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EML4058_12365	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EML4058_12375	COG2205	protein histidine kinase activity
EML4058_12380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EML4058_12385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4058_12390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EML4058_12390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EML4058_12395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EML4058_12400	COG0642	Histidine kinase
EML4058_12405	COG0745	RESPONSE REGULATOR receiver
EML4058_12410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EML4058_12420	COG1072	(Pantothenic acid kinase))
EML4058_12425	COG0140	phosphoribosyl-ATP diphosphatase activity
EML4058_12430	COG0107	imidazoleglycerol-phosphate synthase activity
EML4058_12435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EML4058_12440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EML4058_12450	COG0131	Imidazoleglycerol-phosphate dehydratase
EML4058_12455	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EML4058_12460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EML4058_12470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EML4058_12485	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EML4058_12495	COG1643	Atp-dependent helicase
EML4058_12530	COG0514	ATP-dependent DNA helicase (RecQ)
EML4058_12555	COG1072	(Pantothenic acid kinase))
EML4058_12565	COG1780	Probably involved in ribonucleotide reductase function
EML4058_12585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EML4058_12615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_12625	COG2813	Specifically methylates the guanine in position
EML4058_12630	COG1185	polyribonucleotide nucleotidyltransferase activity
EML4058_12635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EML4058_12640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EML4058_12645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EML4058_12650	COG3064	Membrane
EML4058_12650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EML4058_12665	COG0779	Required for maturation of 30S ribosomal subunits
EML4058_12670	COG2814	Major facilitator Superfamily
EML4058_12675	COG2951	lytic endotransglycosylase activity
EML4058_12680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EML4058_12690	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EML4058_12695	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EML4058_12710	COG2816	NAD+ diphosphatase activity
EML4058_12715	COG1605	Chorismate mutase
EML4058_12715	COG0077	Prephenate dehydratase
EML4058_12720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EML4058_12725	COG3474	cytochrome
EML4058_12735	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EML4058_12740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EML4058_12745	COG1278	Cold shock
EML4058_12750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4058_12765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EML4058_12765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EML4058_12775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EML4058_12805	COG2900	Belongs to the SlyX family
EML4058_12815	COG0484	heat shock protein binding
EML4058_12820	COG0443	Heat shock 70 kDa protein
EML4058_12835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EML4058_12840	COG1744	ABC transporter substrate-binding protein PnrA-like
EML4058_12845	COG3845	ABC transporter
EML4058_12850	COG1079	Belongs to the binding-protein-dependent transport system permease family
EML4058_12855	COG1079	Belongs to the binding-protein-dependent transport system permease family
EML4058_12860	COG0295	cytidine deaminase activity
EML4058_12865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EML4058_12870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EML4058_12875	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EML4058_12885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EML4058_12890	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EML4058_12895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EML4058_12905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EML4058_12910	COG1845	cytochrome c oxidase, subunit III
EML4058_12915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EML4058_12925	COG0477	Major facilitator Superfamily
EML4058_12930	COG0067	glutamate synthase
EML4058_12930	COG0069	glutamate synthase activity
EML4058_12930	COG0070	glutamate synthase
EML4058_12935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EML4058_12950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EML4058_12960	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EML4058_12990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_13010	COG0848	biopolymer transport protein
EML4058_13020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4058_13035	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4058_13040	COG3454	Phosphonate metabolism
EML4058_13045	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EML4058_13050	COG3639	organic phosphonate transmembrane transporter activity
EML4058_13055	COG3639	organic phosphonate transmembrane transporter activity
EML4058_13060	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EML4058_13065	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EML4058_13075	COG4778	phosphonate C-P lyase system protein PhnL
EML4058_13080	COG4107	phosphonate C-P lyase system protein PhnK
EML4058_13085	COG3627	carbon phosphorus lyase activity
EML4058_13090	COG3626	phosphonate metabolism
EML4058_13095	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EML4058_13100	COG3624	Phosphonate C-P lyase system protein PhnG
EML4058_13105	COG2188	Transcriptional regulator
EML4058_13110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EML4058_13115	COG0837	glucose binding
EML4058_13120	COG1803	Methylglyoxal synthase
EML4058_13125	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EML4058_13130	COG4166	transmembrane transport
EML4058_13135	COG4174	ABC transporter (Permease)
EML4058_13140	COG4239	(ABC) transporter, permease
EML4058_13145	COG4172	Belongs to the ABC transporter superfamily
EML4058_13155	COG0174	glutamine synthetase
EML4058_13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_13165	COG3265	gluconokinase activity
EML4058_13170	COG1174	glycine betaine transport
EML4058_13175	COG1125	glycine betaine transport
EML4058_13180	COG1174	glycine betaine transport
EML4058_13185	COG1732	Glycine betaine
EML4058_13195	COG1959	2 iron, 2 sulfur cluster binding
EML4058_13200	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4058_13210	COG4269	membrane
EML4058_13230	COG0697	spore germination
EML4058_13245	COG0791	NLP P60 protein
EML4058_13255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EML4058_13260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EML4058_13295	COG4964	Belongs to the GSP D family
EML4058_13340	COG3422	double-strand break repair
EML4058_13345	COG3757	hydrolase, family 25
EML4058_13350	COG0697	spore germination
EML4058_13355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4058_13385	COG0481	GTPase activity
EML4058_13390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EML4058_13405	COG1396	sequence-specific DNA binding
EML4058_13420	COG1917	Cupin 2, conserved barrel domain protein
EML4058_13420	COG2169	Transcriptional regulator
EML4058_13425	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4058_13450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EML4058_13455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EML4058_13460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EML4058_13470	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EML4058_13475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EML4058_13475	COG0072	phenylalanine-tRNA ligase activity
EML4058_13480	COG0667	Aldo Keto reductase
EML4058_13495	COG0667	Aldo Keto reductase
EML4058_13500	COG4977	sequence-specific DNA binding
EML4058_13525	COG1570	exodeoxyribonuclease VII activity
EML4058_13530	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_13540	COG1846	Transcriptional regulator
EML4058_13545	COG0697	spore germination
EML4058_13550	COG2309	aminopeptidase activity
EML4058_13555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EML4058_13560	COG1393	Belongs to the ArsC family
EML4058_13575	COG1309	transcriptional regulator
EML4058_13585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EML4058_13585	COG0519	Catalyzes the synthesis of GMP from XMP
EML4058_13600	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EML4058_13630	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EML4058_13640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EML4058_13650	COG1968	undecaprenyl-diphosphatase activity
EML4058_13670	COG0284	orotidine-5'-phosphate decarboxylase activity
EML4058_13680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EML4058_13690	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EML4058_13695	COG0792	nuclease activity
EML4058_13710	COG1175	transmembrane transport
EML4058_13715	COG0395	ABC-type sugar transport system, permease component
EML4058_13720	COG3842	ATPase activity
EML4058_13730	COG0189	ligase activity
EML4058_13735	COG0606	chelatase, subunit chli
EML4058_13740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EML4058_13745	COG1280	lysine exporter protein (LysE YggA)
EML4058_13750	COG0756	dUTP diphosphatase activity
EML4058_13755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EML4058_13760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EML4058_13775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EML4058_13780	COG2226	methyltransferase
EML4058_13785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EML4058_13790	COG1024	Enoyl-CoA hydratase
EML4058_13795	COG0268	Binds directly to 16S ribosomal RNA
EML4058_13825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EML4058_13835	COG0640	Transcriptional regulator
EML4058_13880	COG3842	ATPase activity
EML4058_13885	COG4209	transmembrane transport
EML4058_13890	COG0395	ABC-type sugar transport system, permease component
EML4058_13895	COG1653	transport
EML4058_13905	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_13915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_13925	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_13955	COG2197	response regulator
EML4058_13960	COG0601	transmembrane transport
EML4058_13965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_13985	COG0747	negative chemotaxis
EML4058_14000	COG1446	asparaginase
EML4058_14010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_14015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_14020	COG0601	transmembrane transport
EML4058_14060	COG1215	transferase activity, transferring glycosyl groups
EML4058_14070	COG0025	NhaP-type Na H and K H
EML4058_14075	COG4178	(ABC) transporter
EML4058_14085	COG1609	Transcriptional regulator
EML4058_14100	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_14105	COG1735	metal-dependent hydrolase with the TIM-barrel fold
EML4058_14140	COG1794	racemase activity, acting on amino acids and derivatives
EML4058_14145	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_14150	COG1309	transcriptional regulator
EML4058_14155	COG2233	PERMEase
EML4058_14195	COG1595	DNA-templated transcription, initiation
EML4058_14205	COG0395	ABC-type sugar transport system, permease component
EML4058_14210	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_14220	COG3842	ATPase activity
EML4058_14255	COG1653	transport
EML4058_14265	COG0395	ABC-type sugar transport system, permease component
EML4058_14270	COG3842	ATPase activity
EML4058_14275	COG0395	ABC-type sugar transport system, permease component
EML4058_14280	COG1175	transmembrane transport
EML4058_14310	COG1609	Transcriptional regulator
EML4058_14320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_14325	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_14330	COG3842	ATPase activity
EML4058_14335	COG0395	ABC-type sugar transport system, permease component
EML4058_14340	COG1175	transmembrane transport
EML4058_14345	COG1653	transport
EML4058_14350	COG1309	transcriptional regulator
EML4058_14355	COG0673	inositol 2-dehydrogenase activity
EML4058_14370	COG0673	inositol 2-dehydrogenase activity
EML4058_14380	COG1278	Cold shock
EML4058_14390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4058_14415	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EML4058_14430	COG3842	ATPase activity
EML4058_14435	COG0395	ABC-type sugar transport system, permease component
EML4058_14440	COG1175	transmembrane transport
EML4058_14460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_14465	COG3618	amidohydrolase
EML4058_14470	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_14475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_14480	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_14485	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EML4058_14490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_14495	COG2186	Transcriptional regulator
EML4058_14545	COG2223	nitrite transmembrane transporter activity
EML4058_14550	COG0583	DNA-binding transcription factor activity
EML4058_14555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_14565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_14570	COG2084	Dehydrogenase
EML4058_14585	COG1609	Transcriptional regulator
EML4058_14590	COG1063	alcohol dehydrogenase
EML4058_14595	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_14610	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
EML4058_14615	COG1175	transmembrane transport
EML4058_14620	COG0395	ABC-type sugar transport system, permease component
EML4058_14635	COG0395	ABC-type sugar transport system, permease component
EML4058_14640	COG1175	transmembrane transport
EML4058_14645	COG2182	Extracellular solute-binding protein
EML4058_14650	COG0626	cystathionine gamma-synthase activity
EML4058_14665	COG0803	Belongs to the bacterial solute-binding protein 9 family
EML4058_14675	COG1121	(ABC) transporter
EML4058_14680	COG0523	cobalamin synthesis protein
EML4058_14695	COG0523	cobalamin synthesis protein
EML4058_14700	COG1653	transport
EML4058_14705	COG1175	transmembrane transport
EML4058_14710	COG0395	ABC-type sugar transport system, permease component
EML4058_14715	COG3842	ATPase activity
EML4058_14730	COG3047	cAMP biosynthetic process
EML4058_14755	COG0583	DNA-binding transcription factor activity
EML4058_14760	COG1879	ABC-type sugar transport system periplasmic component
EML4058_14765	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_14770	COG1129	ABC transporter
EML4058_14780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EML4058_14785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_14790	COG3447	MASE1 domain protein
EML4058_14790	COG5001	Diguanylate cyclase
EML4058_14790	COG5002	protein histidine kinase activity
EML4058_14795	COG3257	ureidoglycine aminohydrolase activity
EML4058_14805	COG5001	Diguanylate cyclase
EML4058_14810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4058_14825	COG0747	negative chemotaxis
EML4058_14830	COG0601	transmembrane transport
EML4058_14835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_14845	COG4608	Belongs to the ABC transporter superfamily
EML4058_14850	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EML4058_14860	COG0129	dihydroxy-acid dehydratase activity
EML4058_14870	COG1879	ABC-type sugar transport system periplasmic component
EML4058_14875	COG1129	ABC transporter
EML4058_14880	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_14885	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_14890	COG2186	Transcriptional regulator
EML4058_14900	COG0587	DNA-directed DNA polymerase activity
EML4058_14930	COG0673	inositol 2-dehydrogenase activity
EML4058_14940	COG3842	ATPase activity
EML4058_14945	COG0395	ABC-type sugar transport system, permease component
EML4058_14950	COG1175	transmembrane transport
EML4058_14955	COG1653	transport
EML4058_14965	COG0673	inositol 2-dehydrogenase activity
EML4058_14980	COG5001	Diguanylate cyclase
EML4058_14985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_14995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EML4058_15000	COG2894	cell division
EML4058_15005	COG0850	regulation of cytokinetic process
EML4058_15010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4058_15015	COG2186	Transcriptional regulator
EML4058_15020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_15030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_15035	COG1063	alcohol dehydrogenase
EML4058_15040	COG1312	Catalyzes the dehydration of D-mannonate
EML4058_15055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_15060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_15065	COG4172	Belongs to the ABC transporter superfamily
EML4058_15070	COG1921	L-seryl-tRNASec selenium transferase activity
EML4058_15085	COG3964	amidohydrolase
EML4058_15095	COG0601	transmembrane transport
EML4058_15100	COG0747	negative chemotaxis
EML4058_15105	COG0438	transferase activity, transferring glycosyl groups
EML4058_15130	COG2911	Protein conserved in bacteria
EML4058_15130	COG3210	domain, Protein
EML4058_15140	COG4989	oxidoreductase activity
EML4058_15155	COG3842	ATPase activity
EML4058_15160	COG1653	transport
EML4058_15165	COG1175	transmembrane transport
EML4058_15170	COG0395	ABC-type sugar transport system, permease component
EML4058_15175	COG1501	Belongs to the glycosyl hydrolase 31 family
EML4058_15180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_15185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4058_15190	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EML4058_15195	COG0352	thiamine-phosphate diphosphorylase activity
EML4058_15200	COG0351	phosphomethylpyrimidine kinase
EML4058_15205	COG1522	sequence-specific DNA binding
EML4058_15210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EML4058_15215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_15230	COG2204	response regulator
EML4058_15235	COG4191	Histidine kinase
EML4058_15240	COG1301	dicarboxylic acid transport
EML4058_15250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4058_15255	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_15265	COG1473	amidohydrolase
EML4058_15285	COG1215	transferase activity, transferring glycosyl groups
EML4058_15295	COG2942	2-epimerase
EML4058_15330	COG2197	response regulator
EML4058_15360	COG3307	-O-antigen
EML4058_15365	COG1596	polysaccharide export
EML4058_15370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EML4058_15380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4058_15385	COG2972	Histidine kinase
EML4058_15385	COG0840	transmembrane signaling receptor activity
EML4058_15390	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_15390	COG1388	LysM domain
EML4058_15400	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_15410	COG2094	Belongs to the DNA glycosylase MPG family
EML4058_15425	COG1609	Transcriptional regulator
EML4058_15430	COG1653	transport
EML4058_15445	COG3842	ATPase activity
EML4058_15455	COG0673	inositol 2-dehydrogenase activity
EML4058_15460	COG0602	queuosine metabolic process
EML4058_15465	COG0720	synthase
EML4058_15470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EML4058_15475	COG0673	inositol 2-dehydrogenase activity
EML4058_15490	COG0395	ABC-type sugar transport system, permease component
EML4058_15495	COG1175	transmembrane transport
EML4058_15515	COG0583	DNA-binding transcription factor activity
EML4058_15520	COG0281	malic enzyme
EML4058_15520	COG0280	phosphate acetyltransferase
EML4058_15535	COG0765	amino acid transport
EML4058_15540	COG1126	abc transporter atp-binding protein
EML4058_15545	COG2079	MmgE PrpD family protein
EML4058_15550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EML4058_15580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_15585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4058_15590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EML4058_15595	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_15600	COG1129	ABC transporter
EML4058_15610	COG1473	amidohydrolase
EML4058_15630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_15635	COG0601	transmembrane transport
EML4058_15640	COG0583	DNA-binding transcription factor activity
EML4058_15645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_15650	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EML4058_15670	COG1595	DNA-templated transcription, initiation
EML4058_15675	COG1120	ATPase activity
EML4058_15680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_15695	COG2226	methyltransferase
EML4058_15705	COG1120	ATPase activity
EML4058_15710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_15730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4058_15740	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_15745	COG0473	3-isopropylmalate dehydrogenase activity
EML4058_15750	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_15755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_15785	COG0601	transmembrane transport
EML4058_15790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_15795	COG4172	Belongs to the ABC transporter superfamily
EML4058_15800	COG1522	sequence-specific DNA binding
EML4058_15805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_15815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_15820	COG1126	abc transporter atp-binding protein
EML4058_15830	COG1473	amidohydrolase
EML4058_15835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15845	COG1959	2 iron, 2 sulfur cluster binding
EML4058_15855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4058_15860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15880	COG1960	acyl-CoA dehydrogenase activity
EML4058_15915	COG0667	Aldo Keto reductase
EML4058_15925	COG0583	DNA-binding transcription factor activity
EML4058_15930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15950	COG1473	amidohydrolase
EML4058_15955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_15995	COG4608	Belongs to the ABC transporter superfamily
EML4058_16000	COG0444	Belongs to the ABC transporter superfamily
EML4058_16010	COG0601	transmembrane transport
EML4058_16020	COG2186	Transcriptional regulator
EML4058_16045	COG3453	Protein conserved in bacteria
EML4058_16045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4058_16050	COG0640	Transcriptional regulator
EML4058_16060	COG2391	methyltransferase activity
EML4058_16065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EML4058_16075	COG0022	dehydrogenase e1 component
EML4058_16085	COG1960	acyl-CoA dehydrogenase activity
EML4058_16090	COG0183	Belongs to the thiolase family
EML4058_16100	COG1960	acyl-CoA dehydrogenase activity
EML4058_16105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EML4058_16120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EML4058_16125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EML4058_16130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EML4058_16135	COG4952	isomerase
EML4058_16140	COG3347	Dehydrogenase
EML4058_16140	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_16145	COG1349	DNA-binding transcription factor activity
EML4058_16155	COG1129	ABC transporter
EML4058_16160	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_16170	COG3254	rhamnose metabolic process
EML4058_16185	COG2264	protein methyltransferase activity
EML4058_16190	COG5001	Diguanylate cyclase
EML4058_16210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EML4058_16215	COG4208	sulfate ABC transporter
EML4058_16225	COG4150	thiosulfate binding
EML4058_16245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EML4058_16255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EML4058_16265	COG1040	competence protein
EML4058_16270	COG2226	methyltransferase
EML4058_16285	COG0494	nUDIX hydrolase
EML4058_16295	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EML4058_16300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EML4058_16305	COG0653	protein targeting
EML4058_16310	COG0697	spore germination
EML4058_16350	COG1312	Catalyzes the dehydration of D-mannonate
EML4058_16355	COG0246	Mannitol dehydrogenase
EML4058_16375	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_16380	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_16385	COG1129	ABC transporter
EML4058_16415	COG2376	Dihydroxyacetone kinase
EML4058_16420	COG0471	metal ion transport
EML4058_16420	COG3273	potassium ion transport
EML4058_16440	COG0438	transferase activity, transferring glycosyl groups
EML4058_16450	COG2244	polysaccharide biosynthetic process
EML4058_16475	COG3206	protein involved in exopolysaccharide biosynthesis
EML4058_16475	COG0489	protein tyrosine kinase activity
EML4058_16495	COG0438	transferase activity, transferring glycosyl groups
EML4058_16500	COG0438	transferase activity, transferring glycosyl groups
EML4058_16515	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EML4058_16520	COG2273	Hydrolase Family 16
EML4058_16520	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EML4058_16565	COG1396	sequence-specific DNA binding
EML4058_16575	COG1129	ABC transporter
EML4058_16580	COG4214	carbohydrate transport
EML4058_16585	COG4213	ABC transporter substrate-binding protein
EML4058_16600	COG0346	lactoylglutathione lyase activity
EML4058_16605	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EML4058_16605	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EML4058_16610	COG4770	biotin carboxylase activity
EML4058_16620	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EML4058_16630	COG0625	glutathione transferase activity
EML4058_16635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EML4058_16640	COG3800	Transcriptional regulator
EML4058_16640	COG1396	sequence-specific DNA binding
EML4058_16650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EML4058_16660	COG0300	oxidoreductase activity
EML4058_16670	COG2096	Adenosyltransferase
EML4058_16680	COG2086	electron transfer activity
EML4058_16690	COG1250	3-hydroxyacyl-CoA dehydrogenase
EML4058_16695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EML4058_16700	COG0165	Argininosuccinate lyase
EML4058_16735	COG2884	Cell division ATP-binding protein ftsE
EML4058_16755	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EML4058_16765	COG0287	Prephenate dehydrogenase
EML4058_16770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EML4058_16775	COG2226	methyltransferase
EML4058_16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4058_16795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EML4058_16800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EML4058_16835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EML4058_16840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EML4058_16850	COG4974	Belongs to the 'phage' integrase family
EML4058_16855	COG0825	malonyl-CoA metabolic process
EML4058_16860	COG3034	peptidoglycan biosynthetic process
EML4058_16865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EML4058_16865	COG0425	Belongs to the sulfur carrier protein TusA family
EML4058_16870	COG0523	cobalamin synthesis protein
EML4058_16875	COG1686	Belongs to the peptidase S11 family
EML4058_16880	COG1473	amidohydrolase
EML4058_16890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4058_16960	COG0456	acetyltransferase
EML4058_16995	COG2267	carboxylic ester hydrolase activity
EML4058_17005	COG1959	2 iron, 2 sulfur cluster binding
EML4058_17010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EML4058_17050	COG2226	methyltransferase
EML4058_17085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EML4058_17105	COG1629	transport
EML4058_17105	COG4774	siderophore transport
EML4058_17110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EML4058_17115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_17120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_17125	COG1120	ATPase activity
EML4058_17140	COG4953	penicillin-binding protein 1C
EML4058_17145	COG2373	Large extracellular alpha-helical protein
EML4058_17150	COG2835	tetraacyldisaccharide 4'-kinase activity
EML4058_17160	COG3118	belongs to the thioredoxin family
EML4058_17175	COG0625	glutathione transferase activity
EML4058_17185	COG0482	sulfurtransferase activity
EML4058_17200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4058_17215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EML4058_17220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EML4058_17225	COG0037	tRNA processing
EML4058_17235	COG2885	chlorophyll binding
EML4058_17240	COG0823	Involved in the tonB-independent uptake of proteins
EML4058_17260	COG0824	Thioesterase
EML4058_17270	COG0494	nUDIX hydrolase
EML4058_17285	COG2255	four-way junction helicase activity
EML4058_17290	COG0632	four-way junction helicase activity
EML4058_17295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EML4058_17300	COG0840	transmembrane signaling receptor activity
EML4058_17305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_17310	COG0217	transcriptional regulatory protein
EML4058_17325	COG1692	metallophosphoesterase
EML4058_17335	COG1253	flavin adenine dinucleotide binding
EML4058_17365	COG3263	regulation of cellular component size
EML4058_17370	COG0126	phosphoglycerate kinase activity
EML4058_17375	COG3588	fructose-bisphosphate aldolase
EML4058_17400	COG0254	rRNA binding
EML4058_17405	COG1132	(ABC) transporter
EML4058_17425	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_17455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EML4058_17460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EML4058_17465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EML4058_17470	COG0457	Tetratricopeptide repeat
EML4058_17475	COG3750	Belongs to the UPF0335 family
EML4058_17495	COG0469	pyruvate kinase activity
EML4058_17500	COG3108	Peptidase M15
EML4058_17505	COG2204	response regulator
EML4058_17510	COG1164	Oligoendopeptidase f
EML4058_17515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EML4058_17525	COG5310	Homospermidine synthase
EML4058_17535	COG0737	Belongs to the 5'-nucleotidase family
EML4058_17540	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EML4058_17545	COG0330	HflC and HflK could
EML4058_17575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EML4058_17580	COG2951	lytic endotransglycosylase activity
EML4058_17595	COG2205	protein histidine kinase activity
EML4058_17610	COG0067	glutamate synthase
EML4058_17610	COG0069	glutamate synthase activity
EML4058_17610	COG0070	glutamate synthase
EML4058_17620	COG0745	RESPONSE REGULATOR receiver
EML4058_17625	COG2205	protein histidine kinase activity
EML4058_17630	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EML4058_17635	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EML4058_17645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EML4058_17655	COG0252	asparaginase activity
EML4058_17665	COG1027	Aspartate ammonia-lyase
EML4058_17670	COG2186	Transcriptional regulator
EML4058_17710	COG4176	ABC-type proline glycine betaine transport system permease component
EML4058_17715	COG0517	IMP dehydrogenase activity
EML4058_17715	COG4175	Glycine betaine
EML4058_17720	COG2986	histidine ammonia-lyase
EML4058_17725	COG2814	Major facilitator Superfamily
EML4058_17740	COG1522	sequence-specific DNA binding
EML4058_17745	COG0583	DNA-binding transcription factor activity
EML4058_17750	COG0667	Aldo Keto reductase
EML4058_17760	COG1335	isochorismatase
EML4058_17770	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_17775	COG3254	rhamnose metabolic process
EML4058_17790	COG2721	sulfolactate sulfo-lyase activity
EML4058_17795	COG1129	ABC transporter
EML4058_17805	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_17810	COG1879	ABC-type sugar transport system periplasmic component
EML4058_18000	COG2308	Evidence 4 Homologs of previously reported genes of
EML4058_18000	COG2307	Protein conserved in bacteria
EML4058_18015	COG0488	(ABC) transporter
EML4058_18020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_18025	COG1304	FMN binding
EML4058_18035	COG1846	Transcriptional regulator
EML4058_18050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EML4058_18055	COG0667	Aldo Keto reductase
EML4058_18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_18070	COG1129	ABC transporter
EML4058_18075	COG1879	ABC-type sugar transport system periplasmic component
EML4058_18110	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4058_18125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EML4058_18140	COG0395	ABC-type sugar transport system, permease component
EML4058_18155	COG3842	ATPase activity
EML4058_18170	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EML4058_18170	COG1648	precorrin-2 dehydrogenase activity
EML4058_18175	COG0243	molybdopterin cofactor binding
EML4058_18185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EML4058_18190	COG1116	anion transmembrane transporter activity
EML4058_18195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_18200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4058_18210	COG3707	response regulator
EML4058_18215	COG1802	Transcriptional regulator
EML4058_18220	COG1914	H( )-stimulated, divalent metal cation uptake system
EML4058_18225	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EML4058_18230	COG4336	lyase activity
EML4058_18235	COG1984	allophanate hydrolase subunit 2
EML4058_18240	COG4770	biotin carboxylase activity
EML4058_18245	COG0366	Alpha amylase catalytic
EML4058_18255	COG4771	TonB-dependent receptor
EML4058_18285	COG1414	Transcriptional regulator
EML4058_18290	COG1475	DNA binding
EML4058_18295	COG1192	Involved in chromosome partitioning
EML4058_18330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EML4058_18340	COG2986	histidine ammonia-lyase
EML4058_18345	COG1228	amidohydrolase
EML4058_18350	COG0402	S-adenosylhomocysteine deaminase activity
EML4058_18400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_18410	COG2423	ornithine cyclodeaminase activity
EML4058_18425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_18430	COG3938	Belongs to the proline racemase family
EML4058_18435	COG4176	ABC-type proline glycine betaine transport system permease component
EML4058_18445	COG3448	diguanylate cyclase activity
EML4058_18445	COG4175	Glycine betaine
EML4058_18455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_18460	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_18465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_18490	COG0673	inositol 2-dehydrogenase activity
EML4058_18495	COG0673	inositol 2-dehydrogenase activity
EML4058_18505	COG1175	transmembrane transport
EML4058_18510	COG0395	ABC-type sugar transport system, permease component
EML4058_18515	COG3842	ATPase activity
EML4058_18525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_18530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4058_18555	COG0583	DNA-binding transcription factor activity
EML4058_18560	COG0346	lactoylglutathione lyase activity
EML4058_18575	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EML4058_18585	COG2814	Major facilitator Superfamily
EML4058_18600	COG0583	DNA-binding transcription factor activity
EML4058_18605	COG0477	Major facilitator Superfamily
EML4058_18655	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EML4058_18665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EML4058_18670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4058_18675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EML4058_18705	COG0010	Belongs to the arginase family
EML4058_18725	COG0697	spore germination
EML4058_18730	COG0673	inositol 2-dehydrogenase activity
EML4058_18750	COG0477	Major facilitator Superfamily
EML4058_18755	COG0642	Histidine kinase
EML4058_18765	COG2194	sulfuric ester hydrolase activity
EML4058_18770	COG0583	DNA-binding transcription factor activity
EML4058_18775	COG4774	siderophore transport
EML4058_18790	COG1120	ATPase activity
EML4058_18800	COG3474	cytochrome
EML4058_18805	COG2137	regulation of response to DNA damage stimulus
EML4058_18810	COG3386	PFAM SMP-30 Gluconolaconase
EML4058_18820	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_18825	COG1129	ABC transporter
EML4058_18830	COG1879	ABC-type sugar transport system periplasmic component
EML4058_18835	COG4585	Histidine kinase
EML4058_18840	COG2197	response regulator
EML4058_18850	COG2133	pyrroloquinoline quinone binding
EML4058_18860	COG0500	methyltransferase
EML4058_18865	COG0564	pseudouridine synthase activity
EML4058_18880	COG4175	Glycine betaine
EML4058_18880	COG0517	IMP dehydrogenase activity
EML4058_18885	COG4176	ABC-type proline glycine betaine transport system permease component
EML4058_18895	COG0784	Response regulator, receiver
EML4058_18895	COG4191	Histidine kinase
EML4058_18900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4058_18905	COG3206	protein involved in exopolysaccharide biosynthesis
EML4058_18905	COG0489	protein tyrosine kinase activity
EML4058_18910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EML4058_18915	COG1215	transferase activity, transferring glycosyl groups
EML4058_18920	COG1215	transferase activity, transferring glycosyl groups
EML4058_18925	COG1215	transferase activity, transferring glycosyl groups
EML4058_18930	COG0438	transferase activity, transferring glycosyl groups
EML4058_18935	COG2273	Hydrolase Family 16
EML4058_18940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EML4058_18945	COG2244	polysaccharide biosynthetic process
EML4058_18950	COG0463	Glycosyl transferase, family 2
EML4058_18955	COG2327	Polysaccharide pyruvyl transferase
EML4058_18960	COG1215	transferase activity, transferring glycosyl groups
EML4058_18980	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EML4058_18985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_19000	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4058_19000	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4058_19025	COG0033	Phosphoglucomutase
EML4058_19030	COG0297	glycogen (starch) synthase activity
EML4058_19035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EML4058_19040	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EML4058_19045	COG0058	SHG alpha-glucan phosphorylase activity
EML4058_19055	COG1794	racemase activity, acting on amino acids and derivatives
EML4058_19060	COG1522	sequence-specific DNA binding
EML4058_19070	COG2084	Dehydrogenase
EML4058_19075	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_19080	COG1063	alcohol dehydrogenase
EML4058_19090	COG4988	ABC transporter
EML4058_19095	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EML4058_19105	COG1294	oxidase, subunit
EML4058_19135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EML4058_19140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EML4058_19170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EML4058_19175	COG0539	negative regulation of cytoplasmic translation
EML4058_19205	COG4221	oxidoreductase activity
EML4058_19210	COG0006	proline dipeptidase activity
EML4058_19215	COG0747	negative chemotaxis
EML4058_19220	COG0601	transmembrane transport
EML4058_19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_19230	COG0444	Belongs to the ABC transporter superfamily
EML4058_19235	COG4608	Belongs to the ABC transporter superfamily
EML4058_19250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_19275	COG0559	Belongs to the binding-protein-dependent transport system permease family
EML4058_19295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EML4058_19300	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_19320	COG4993	Dehydrogenase
EML4058_19325	COG3685	Protein conserved in bacteria
EML4058_19355	COG0693	protein deglycase activity
EML4058_19375	COG0189	ligase activity
EML4058_19380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_19385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EML4058_19395	COG0583	DNA-binding transcription factor activity
EML4058_19400	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_19405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EML4058_19410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_19415	COG1116	anion transmembrane transporter activity
EML4058_19425	COG1522	sequence-specific DNA binding
EML4058_19440	COG0784	Response regulator, receiver
EML4058_19450	COG3920	Histidine kinase
EML4058_19460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EML4058_19475	COG0019	diaminopimelate decarboxylase activity
EML4058_19485	COG0513	Belongs to the DEAD box helicase family
EML4058_19490	COG0527	aspartate kinase activity
EML4058_19500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EML4058_19505	COG2890	protein-(glutamine-N5) methyltransferase activity
EML4058_19515	COG0542	response to heat
EML4058_19520	COG1196	nuclear chromosome segregation
EML4058_19520	COG0741	lytic transglycosylase activity
EML4058_19520	COG0739	heme binding
EML4058_19560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_19570	COG2186	Transcriptional regulator
EML4058_19575	COG0747	negative chemotaxis
EML4058_19580	COG0601	transmembrane transport
EML4058_19585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_19590	COG4172	Belongs to the ABC transporter superfamily
EML4058_19595	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_19630	COG1881	PFAM PEBP family protein
EML4058_19665	COG3833	ABC-type maltose transport systems, permease component
EML4058_19675	COG0584	glycerophosphoryl diester phosphodiesterase
EML4058_19680	COG1278	Cold shock
EML4058_19690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EML4058_19710	COG0300	oxidoreductase activity
EML4058_19720	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4058_19720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4058_19725	COG4311	Sarcosine oxidase, delta subunit
EML4058_19730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_19735	COG4977	sequence-specific DNA binding
EML4058_19745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EML4058_19750	COG2218	PFAM glutamate synthase alpha subunit domain protein
EML4058_19755	COG0069	glutamate synthase activity
EML4058_19760	COG0174	glutamine synthetase
EML4058_19780	COG0765	amino acid transport
EML4058_19785	COG1126	abc transporter atp-binding protein
EML4058_19790	COG1454	alcohol dehydrogenase
EML4058_19800	COG2267	carboxylic ester hydrolase activity
EML4058_19810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_19815	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_19835	COG1177	transmembrane transport
EML4058_19840	COG3842	ATPase activity
EML4058_19855	COG3842	ATPase activity
EML4058_19860	COG0395	ABC-type sugar transport system, permease component
EML4058_19865	COG1175	transmembrane transport
EML4058_19875	COG1053	succinate dehydrogenase
EML4058_19875	COG3976	FMN-binding domain protein
EML4058_19880	COG1609	Transcriptional regulator
EML4058_19890	COG4172	Belongs to the ABC transporter superfamily
EML4058_19895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_19900	COG0601	transmembrane transport
EML4058_19910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_19925	COG2828	Protein conserved in bacteria
EML4058_19930	COG0583	DNA-binding transcription factor activity
EML4058_19940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4058_19960	COG0494	nUDIX hydrolase
EML4058_19965	COG0583	DNA-binding transcription factor activity
EML4058_19975	COG0511	ligase activity, forming carbon-carbon bonds
EML4058_19980	COG0439	Biotin carboxylase
EML4058_19995	COG1984	allophanate hydrolase subunit 2
EML4058_20000	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EML4058_20005	COG0436	Aminotransferase
EML4058_20015	COG4221	oxidoreductase activity
EML4058_20020	COG0765	amino acid transport
EML4058_20025	COG0765	amino acid transport
EML4058_20030	COG1126	abc transporter atp-binding protein
EML4058_20035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_20040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4058_20055	COG0583	DNA-binding transcription factor activity
EML4058_20065	COG0583	DNA-binding transcription factor activity
EML4058_20070	COG2814	Major facilitator Superfamily
EML4058_20085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EML4058_20095	COG2207	Transcriptional regulator
EML4058_20100	COG0668	transmembrane transport
EML4058_20110	COG4566	intracellular signal transduction
EML4058_20130	COG0668	transmembrane transport
EML4058_20135	COG4191	Histidine kinase
EML4058_20140	COG2205	protein histidine kinase activity
EML4058_20140	COG5002	protein histidine kinase activity
EML4058_20140	COG0784	Response regulator, receiver
EML4058_20145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4058_20155	COG0047	phosphoribosylformylglycinamidine synthase activity
EML4058_20170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EML4058_20170	COG0446	pyridine nucleotide-disulphide oxidoreductase
EML4058_20180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EML4058_20195	COG1309	transcriptional regulator
EML4058_20200	COG1063	alcohol dehydrogenase
EML4058_20210	COG1879	ABC-type sugar transport system periplasmic component
EML4058_20220	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_20370	COG5001	Diguanylate cyclase
EML4058_20380	COG1253	flavin adenine dinucleotide binding
EML4058_20395	COG3842	ATPase activity
EML4058_20400	COG0395	ABC-type sugar transport system, permease component
EML4058_20405	COG1175	transmembrane transport
EML4058_20410	COG1653	transport
EML4058_20420	COG0673	inositol 2-dehydrogenase activity
EML4058_20425	COG1609	Transcriptional regulator
EML4058_20435	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_20440	COG0583	DNA-binding transcription factor activity
EML4058_20450	COG1879	ABC-type sugar transport system periplasmic component
EML4058_20455	COG1129	ABC transporter
EML4058_20460	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_20465	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_20470	COG1609	Transcriptional regulator
EML4058_20480	COG0673	inositol 2-dehydrogenase activity
EML4058_20540	COG0714	Associated with various cellular activities
EML4058_20545	COG3256	nitric oxide reductase
EML4058_20575	COG0163	prenyltransferase activity
EML4058_20580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EML4058_20585	COG3189	MarR family transcriptional regulator
EML4058_20595	COG0826	peptidase U32
EML4058_20635	COG4459	periplasmic nitrate reductase
EML4058_20650	COG0243	molybdopterin cofactor binding
EML4058_20660	COG3005	denitrification pathway
EML4058_20665	COG0583	DNA-binding transcription factor activity
EML4058_20675	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
EML4058_20680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_20695	COG1960	acyl-CoA dehydrogenase activity
EML4058_20700	COG0583	DNA-binding transcription factor activity
EML4058_20705	COG1609	Transcriptional regulator
EML4058_20715	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_20725	COG3842	ATPase activity
EML4058_20735	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EML4058_20745	COG1473	amidohydrolase
EML4058_20760	COG0747	negative chemotaxis
EML4058_20765	COG0601	transmembrane transport
EML4058_20770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_20775	COG0444	Belongs to the ABC transporter superfamily
EML4058_20780	COG4608	Belongs to the ABC transporter superfamily
EML4058_20790	COG0583	DNA-binding transcription factor activity
EML4058_20795	COG0747	negative chemotaxis
EML4058_20805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_20810	COG0154	amidase activity
EML4058_20815	COG0693	protein deglycase activity
EML4058_20825	COG1473	amidohydrolase
EML4058_20830	COG4172	Belongs to the ABC transporter superfamily
EML4058_20835	COG2390	Transcriptional regulator
EML4058_20845	COG1175	transmembrane transport
EML4058_20850	COG0395	ABC-type sugar transport system, permease component
EML4058_20865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EML4058_20870	COG1069	ribulokinase activity
EML4058_20875	COG1737	Transcriptional regulator
EML4058_20895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EML4058_20915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EML4058_20920	COG1414	Transcriptional regulator
EML4058_20925	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_20935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4058_20940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EML4058_20945	COG1121	(ABC) transporter
EML4058_20950	COG0803	Belongs to the bacterial solute-binding protein 9 family
EML4058_20960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EML4058_20965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EML4058_20970	COG0471	metal ion transport
EML4058_20970	COG3273	potassium ion transport
EML4058_20975	COG1253	flavin adenine dinucleotide binding
EML4058_20980	COG1309	transcriptional regulator
EML4058_21000	COG1609	Transcriptional regulator
EML4058_21005	COG1070	Carbohydrate kinase
EML4058_21010	COG2115	Belongs to the xylose isomerase family
EML4058_21020	COG0778	Nitroreductase
EML4058_21025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EML4058_21030	COG2011	ABC-type metal ion transport system permease component
EML4058_21040	COG3300	MHYT domain
EML4058_21040	COG5001	Diguanylate cyclase
EML4058_21045	COG1054	Belongs to the UPF0176 family
EML4058_21055	COG2954	triphosphatase activity
EML4058_21060	COG0800	Aldolase
EML4058_21080	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EML4058_21100	COG0523	cobalamin synthesis protein
EML4058_21110	COG1846	Transcriptional regulator
EML4058_21115	COG1609	Transcriptional regulator
EML4058_21120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_21125	COG0673	inositol 2-dehydrogenase activity
EML4058_21130	COG3718	enzyme involved in inositol metabolism
EML4058_21140	COG3962	Belongs to the TPP enzyme family
EML4058_21145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_21160	COG0411	ABC transporter
EML4058_21175	COG0683	leucine binding
EML4058_21195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_21205	COG0747	negative chemotaxis
EML4058_21220	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EML4058_21220	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_21230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EML4058_21235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EML4058_21240	COG1126	abc transporter atp-binding protein
EML4058_21245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_21250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_21255	COG0765	amino acid transport
EML4058_21260	COG0765	amino acid transport
EML4058_21270	COG3485	protocatechuate 3,4-dioxygenase
EML4058_21275	COG3485	protocatechuate 3,4-dioxygenase
EML4058_21280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EML4058_21290	COG0583	DNA-binding transcription factor activity
EML4058_21305	COG1414	Transcriptional regulator
EML4058_21315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EML4058_21320	COG0183	Belongs to the thiolase family
EML4058_21325	COG1609	Transcriptional regulator
EML4058_21340	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_21345	COG0673	inositol 2-dehydrogenase activity
EML4058_21355	COG1609	Transcriptional regulator
EML4058_21360	COG0395	ABC-type sugar transport system, permease component
EML4058_21365	COG1175	transmembrane transport
EML4058_21370	COG3842	ATPase activity
EML4058_21380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EML4058_21400	COG1940	carbohydrate kinase activity
EML4058_21410	COG3842	ATPase activity
EML4058_21415	COG4149	molybdate abc transporter
EML4058_21425	COG0584	glycerophosphoryl diester phosphodiesterase
EML4058_21430	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_21435	COG0300	oxidoreductase activity
EML4058_21455	COG3842	ATPase activity
EML4058_21475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EML4058_21510	COG0667	Aldo Keto reductase
EML4058_21515	COG0583	DNA-binding transcription factor activity
EML4058_21525	COG0179	Fumarylacetoacetate (FAA) hydrolase
EML4058_21535	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_21545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EML4058_21560	COG1132	(ABC) transporter
EML4058_21595	COG1215	transferase activity, transferring glycosyl groups
EML4058_21610	COG1215	transferase activity, transferring glycosyl groups
EML4058_21620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EML4058_21625	COG1091	dTDP-4-dehydrorhamnose reductase activity
EML4058_21630	COG1088	dTDP-glucose 4,6-dehydratase activity
EML4058_21635	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EML4058_21650	COG0444	Belongs to the ABC transporter superfamily
EML4058_21655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_21660	COG0601	transmembrane transport
EML4058_21665	COG2186	Transcriptional regulator
EML4058_21670	COG1312	Catalyzes the dehydration of D-mannonate
EML4058_21675	COG0747	negative chemotaxis
EML4058_21685	COG3300	MHYT domain
EML4058_21685	COG5001	Diguanylate cyclase
EML4058_21690	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_21700	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EML4058_21715	COG1392	Phosphate transport regulator
EML4058_21740	COG5002	protein histidine kinase activity
EML4058_21755	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EML4058_21770	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_21785	COG3119	arylsulfatase activity
EML4058_21790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EML4058_21795	COG3842	ATPase activity
EML4058_21800	COG0165	Argininosuccinate lyase
EML4058_21805	COG0395	ABC-type sugar transport system, permease component
EML4058_21810	COG1175	transmembrane transport
EML4058_21815	COG2182	Extracellular solute-binding protein
EML4058_21820	COG1940	carbohydrate kinase activity
EML4058_21845	COG1486	melibiose metabolic process
EML4058_21850	COG0747	negative chemotaxis
EML4058_21855	COG0601	transmembrane transport
EML4058_21860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_21865	COG4172	Belongs to the ABC transporter superfamily
EML4058_21870	COG1486	melibiose metabolic process
EML4058_21875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_21880	COG0842	Transport permease protein
EML4058_21880	COG1129	ABC transporter
EML4058_21885	COG0842	Transport permease protein
EML4058_21900	COG0784	Response regulator, receiver
EML4058_21905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EML4058_21915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_21920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EML4058_21935	COG0765	amino acid transport
EML4058_21945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_21955	COG3938	Belongs to the proline racemase family
EML4058_21970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_21975	COG0765	amino acid transport
EML4058_21980	COG0765	amino acid transport
EML4058_21990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_22005	COG0402	S-adenosylhomocysteine deaminase activity
EML4058_22015	COG0601	transmembrane transport
EML4058_22020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_22030	COG0402	S-adenosylhomocysteine deaminase activity
EML4058_22035	COG0444	Belongs to the ABC transporter superfamily
EML4058_22040	COG4608	Belongs to the ABC transporter superfamily
EML4058_22045	COG1802	Transcriptional regulator
EML4058_22050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EML4058_22075	COG3383	formate dehydrogenase (NAD+) activity
EML4058_22085	COG2223	nitrite transmembrane transporter activity
EML4058_22115	COG3237	CsbD-like
EML4058_22120	COG2197	response regulator
EML4058_22125	COG2186	Transcriptional regulator
EML4058_22130	COG0747	negative chemotaxis
EML4058_22135	COG0601	transmembrane transport
EML4058_22140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_22145	COG0405	Gamma-glutamyltransferase
EML4058_22155	COG3237	CsbD-like
EML4058_22165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EML4058_22170	COG3181	Tripartite tricarboxylate transporter family receptor
EML4058_22175	COG5265	(ABC) transporter
EML4058_22180	COG0488	(ABC) transporter
EML4058_22205	COG1049	propionate catabolic process, 2-methylcitrate cycle
EML4058_22210	COG0840	transmembrane signaling receptor activity
EML4058_22220	COG0110	maltose O-acetyltransferase activity
EML4058_22230	COG1063	alcohol dehydrogenase
EML4058_22235	COG3284	Transcriptional regulator
EML4058_22255	COG1129	ABC transporter
EML4058_22260	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_22265	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_22280	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_22290	COG1126	abc transporter atp-binding protein
EML4058_22295	COG0765	amino acid transport
EML4058_22300	COG0765	amino acid transport
EML4058_22305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_22310	COG3608	succinylglutamate desuccinylase aspartoacylase
EML4058_22315	COG0006	proline dipeptidase activity
EML4058_22320	COG2423	ornithine cyclodeaminase activity
EML4058_22325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EML4058_22330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EML4058_22335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EML4058_22340	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_22345	COG1522	sequence-specific DNA binding
EML4058_22355	COG3046	protein related to deoxyribodipyrimidine photolyase
EML4058_22385	COG2140	Oxalate decarboxylase
EML4058_22400	COG4566	intracellular signal transduction
EML4058_22410	COG0243	molybdopterin cofactor binding
EML4058_22415	COG0783	Belongs to the Dps family
EML4058_22435	COG0784	Response regulator, receiver
EML4058_22435	COG4191	Histidine kinase
EML4058_22445	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4058_22450	COG1840	ABC-type Fe3 transport system, periplasmic component
EML4058_22460	COG3842	ATPase activity
EML4058_22465	COG0483	inositol monophosphate 1-phosphatase activity
EML4058_22480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_22505	COG2197	response regulator
EML4058_22510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EML4058_22515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EML4058_22525	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EML4058_22530	COG4310	Domain of unknown function (DUF2172)
EML4058_22535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EML4058_22540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EML4058_22545	COG2197	response regulator
EML4058_22550	COG4566	intracellular signal transduction
EML4058_22580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EML4058_22600	COG0438	transferase activity, transferring glycosyl groups
EML4058_22615	COG1522	sequence-specific DNA binding
EML4058_22635	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_22650	COG1414	Transcriptional regulator
EML4058_22660	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EML4058_22680	COG0582	viral genome integration into host DNA
EML4058_22700	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EML4058_22730	COG1349	DNA-binding transcription factor activity
EML4058_22735	COG1879	ABC-type sugar transport system periplasmic component
EML4058_22740	COG1129	ABC transporter
EML4058_22745	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_22750	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_22770	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_22845	COG1846	Transcriptional regulator
EML4058_22865	COG0667	Aldo Keto reductase
EML4058_22875	COG0604	alcohol dehydrogenase
EML4058_22885	COG1309	transcriptional regulator
EML4058_22900	COG0667	Aldo Keto reductase
EML4058_22905	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_22920	COG2207	Transcriptional regulator
EML4058_22920	COG0662	Cupin 2, conserved barrel domain protein
EML4058_22980	COG4584	PFAM Integrase catalytic
EML4058_23000	COG1192	Involved in chromosome partitioning
EML4058_23005	COG1475	DNA binding
EML4058_23010	COG0640	Transcriptional regulator
EML4058_23025	COG1126	abc transporter atp-binding protein
EML4058_23030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_23035	COG1609	Transcriptional regulator
EML4058_23115	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EML4058_23120	COG0210	DNA helicase
EML4058_23180	COG3177	Filamentation induced by cAMP protein fic
EML4058_23255	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4058_23290	COG1175	transmembrane transport
EML4058_23295	COG0395	ABC-type sugar transport system, permease component
EML4058_23305	COG3842	ATPase activity
EML4058_23310	COG1737	Transcriptional regulator
EML4058_23315	COG1846	Transcriptional regulator
EML4058_23330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_23340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_23345	COG0601	transmembrane transport
EML4058_23350	COG0747	negative chemotaxis
EML4058_23360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EML4058_23365	COG1454	alcohol dehydrogenase
EML4058_23375	COG3395	kinase activity
EML4058_23385	COG1609	Transcriptional regulator
EML4058_23425	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EML4058_23430	COG3920	Histidine kinase
EML4058_23440	COG1215	transferase activity, transferring glycosyl groups
EML4058_23485	COG0587	DNA-directed DNA polymerase activity
EML4058_23505	COG5489	Protein of unknown function (DUF736)
EML4058_23520	COG3831	ATPase activity
EML4058_23525	COG3505	Type IV secretory pathway VirD4
EML4058_23575	COG0156	8-amino-7-oxononanoate synthase activity
EML4058_23580	COG0745	RESPONSE REGULATOR receiver
EML4058_23590	COG0745	RESPONSE REGULATOR receiver
EML4058_23595	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_23600	COG0028	Belongs to the TPP enzyme family
EML4058_23605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EML4058_23615	COG3842	ATPase activity
EML4058_23620	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_23625	COG1177	transmembrane transport
EML4058_23650	COG1414	Transcriptional regulator
EML4058_23660	COG1454	alcohol dehydrogenase
EML4058_23665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EML4058_23695	COG1285	pathogenesis
EML4058_23715	COG1733	regulation of RNA biosynthetic process
EML4058_23755	COG3838	Conjugal transfer protein Trbc
EML4058_23760	COG3702	type iv secretory pathway
EML4058_23765	COG3451	type IV secretory pathway VirB4
EML4058_23780	COG3704	protein secretion by the type IV secretion system
EML4058_23790	COG3736	Type IV secretory pathway, component VirB8
EML4058_23795	COG3504	Conjugal transfer protein
EML4058_23800	COG2948	multi-organism process
EML4058_23805	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
EML4058_23820	COG0745	RESPONSE REGULATOR receiver
EML4058_23830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EML4058_23835	COG1136	(ABC) transporter
EML4058_23835	COG0577	efflux transmembrane transporter activity
EML4058_23845	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_23850	COG1063	alcohol dehydrogenase
EML4058_23860	COG0583	DNA-binding transcription factor activity
EML4058_23865	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_23870	COG0583	DNA-binding transcription factor activity
EML4058_23885	COG2267	carboxylic ester hydrolase activity
EML4058_23890	COG0673	inositol 2-dehydrogenase activity
EML4058_23900	COG0789	Transcriptional regulator
EML4058_23910	COG1376	ErfK ybiS ycfS ynhG family protein
EML4058_23920	COG0667	Aldo Keto reductase
EML4058_23925	COG0673	inositol 2-dehydrogenase activity
EML4058_23950	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_23960	COG0583	DNA-binding transcription factor activity
EML4058_23970	COG0583	DNA-binding transcription factor activity
EML4058_23980	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_23985	COG1846	Transcriptional regulator
EML4058_24000	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_24015	COG4176	ABC-type proline glycine betaine transport system permease component
EML4058_24020	COG2113	Glycine betaine
EML4058_24025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4058_24050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EML4058_24055	COG1012	belongs to the aldehyde dehydrogenase family
EML4058_24085	COG0765	amino acid transport
EML4058_24100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_24105	COG3608	succinylglutamate desuccinylase aspartoacylase
EML4058_24110	COG1609	Transcriptional regulator
EML4058_24120	COG0583	DNA-binding transcription factor activity
EML4058_24135	COG1335	isochorismatase
EML4058_24140	COG1177	transmembrane transport
EML4058_24145	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_24150	COG3842	ATPase activity
EML4058_24175	COG0747	negative chemotaxis
EML4058_24180	COG0601	transmembrane transport
EML4058_24185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_24190	COG0444	Belongs to the ABC transporter superfamily
EML4058_24195	COG4608	Belongs to the ABC transporter superfamily
EML4058_24215	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EML4058_24220	COG0395	ABC-type sugar transport system, permease component
EML4058_24245	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EML4058_24250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EML4058_24260	COG2378	regulation of single-species biofilm formation
EML4058_24270	COG1846	Transcriptional regulator
EML4058_24285	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_24295	COG3685	Protein conserved in bacteria
EML4058_24325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EML4058_24330	COG0297	glycogen (starch) synthase activity
EML4058_24350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EML4058_24380	COG0596	Alpha beta hydrolase
EML4058_24405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EML4058_24410	COG0583	DNA-binding transcription factor activity
EML4058_24420	COG0372	Belongs to the citrate synthase family
EML4058_24445	COG4774	siderophore transport
EML4058_24450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EML4058_24460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_24465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EML4058_24470	COG1120	ATPase activity
EML4058_24485	COG0640	Transcriptional regulator
EML4058_24490	COG0431	NADPH-dependent FMN reductase
EML4058_24500	COG0604	alcohol dehydrogenase
EML4058_24510	COG0583	DNA-binding transcription factor activity
EML4058_24515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EML4058_24520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EML4058_24540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EML4058_24570	COG0583	DNA-binding transcription factor activity
EML4058_24585	COG1177	transmembrane transport
EML4058_24590	COG3842	ATPase activity
EML4058_24595	COG2072	flavoprotein involved in K transport
EML4058_24615	COG0534	Mate efflux family protein
EML4058_24635	COG1609	Transcriptional regulator
EML4058_24640	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_24645	COG0673	inositol 2-dehydrogenase activity
EML4058_24650	COG1082	Xylose isomerase domain protein TIM barrel
EML4058_24660	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_24680	COG0840	transmembrane signaling receptor activity
EML4058_24680	COG2972	Histidine kinase
EML4058_24690	COG4221	oxidoreductase activity
EML4058_24695	COG1902	pentaerythritol trinitrate reductase activity
EML4058_24700	COG0596	Alpha beta hydrolase
EML4058_24710	COG3831	ATPase activity
EML4058_24715	COG0071	Belongs to the small heat shock protein (HSP20) family
EML4058_24730	COG0577	efflux transmembrane transporter activity
EML4058_24745	COG3734	2-keto-3-deoxy-galactonokinase
EML4058_24750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EML4058_24755	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_24765	COG1175	transmembrane transport
EML4058_24770	COG0395	ABC-type sugar transport system, permease component
EML4058_24775	COG3842	ATPase activity
EML4058_24780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EML4058_24785	COG1414	Transcriptional regulator
EML4058_24790	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_24795	COG3158	transport of potassium into the cell
EML4058_24805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EML4058_24835	COG0504	CTP synthase activity
EML4058_24840	COG0006	proline dipeptidase activity
EML4058_24845	COG4948	Mandelate Racemase Muconate Lactonizing
EML4058_24850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EML4058_24860	COG0765	amino acid transport
EML4058_24865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EML4058_24910	COG0753	catalase activity
EML4058_24925	COG3685	Protein conserved in bacteria
EML4058_24935	COG1309	transcriptional regulator
EML4058_24940	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EML4058_24945	COG2080	2 iron, 2 sulfur cluster binding
EML4058_24950	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
EML4058_24955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EML4058_24960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EML4058_25000	COG4191	Histidine kinase
EML4058_25000	COG0784	Response regulator, receiver
EML4058_25005	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
EML4058_25020	COG1278	Cold shock
EML4058_25060	COG1172	Belongs to the binding-protein-dependent transport system permease family
EML4058_25085	COG3920	Histidine kinase
EML4058_25135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EML4058_25145	COG1566	PFAM secretion protein HlyD family protein
EML4058_25165	COG2207	Transcriptional regulator
EML4058_25190	COG1192	Involved in chromosome partitioning
EML4058_25195	COG1475	DNA binding
EML4058_25200	COG0640	Transcriptional regulator
EML4058_25210	COG5001	Diguanylate cyclase
EML4058_25210	COG3300	MHYT domain
EML4058_25440	COG4372	Transposase
EML4058_25445	COG3436	PFAM IS66 Orf2 family protein
EML4058_25450	COG2963	transposase activity
EML4058_25460	COG3436	PFAM IS66 Orf2 family protein
EML4058_25530	COG1278	Cold shock
EML4058_25565	COG0546	phosphoglycolate phosphatase activity
EML4058_25710	COG4172	Belongs to the ABC transporter superfamily
EML4058_25715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_25720	COG0601	transmembrane transport
EML4058_25795	COG1177	transmembrane transport
EML4058_25800	COG1176	ABC-type spermidine putrescine transport system, permease component I
EML4058_25815	COG0840	transmembrane signaling receptor activity
EML4058_25815	COG2972	Histidine kinase
EML4058_25830	COG3842	ATPase activity
EML4058_25835	COG0006	proline dipeptidase activity
EML4058_25855	COG0300	oxidoreductase activity
EML4058_25860	COG0129	dihydroxy-acid dehydratase activity
EML4058_25865	COG0667	Aldo Keto reductase
EML4058_25875	COG1028	Short-chain dehydrogenase reductase Sdr
EML4058_25885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_25890	COG0601	transmembrane transport
EML4058_25895	COG4172	Belongs to the ABC transporter superfamily
EML4058_25905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EML4058_25940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EML4058_25945	COG4172	Belongs to the ABC transporter superfamily
EML4058_25970	COG3701	Conjugal transfer protein
EML4058_25975	COG3846	protein secretion by the type IV secretion system
EML4058_25985	COG5314	conjugation
EML4058_25990	COG3451	type IV secretory pathway VirB4
EML4058_26005	COG4962	Type ii secretion system protein e