locus-tag	class	description
J5285_00035	COG0840	transmembrane signaling receptor activity
J5285_00050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5285_00080	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_00085	COG2814	Major facilitator Superfamily
J5285_00090	COG1309	transcriptional regulator
J5285_00115	COG0174	glutamine synthetase
J5285_00120	COG0531	amino acid
J5285_00150	COG3842	ATPase activity
J5285_00160	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
J5285_00170	COG0477	Major facilitator Superfamily
J5285_00180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5285_00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5285_00195	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J5285_00230	COG2968	Membrane
J5285_00240	COG0432	Pfam Uncharacterised protein family UPF0047
J5285_00255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5285_00260	COG0358	DNA primase activity
J5285_00280	COG0505	Belongs to the CarA family
J5285_00285	COG0534	Mate efflux family protein
J5285_00300	COG2321	neutral zinc metallopeptidase
J5285_00310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J5285_00320	COG0477	Major facilitator Superfamily
J5285_00330	COG1573	uracil-dna glycosylase
J5285_00340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5285_00345	COG0438	transferase activity, transferring glycosyl groups
J5285_00350	COG0438	transferase activity, transferring glycosyl groups
J5285_00355	COG0438	transferase activity, transferring glycosyl groups
J5285_00360	COG0463	Glycosyl transferase, family 2
J5285_00370	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
J5285_00375	COG1088	dTDP-glucose 4,6-dehydratase activity
J5285_00380	COG1091	dTDP-4-dehydrorhamnose reductase activity
J5285_00385	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J5285_00395	COG1522	sequence-specific DNA binding
J5285_00400	COG0492	ferredoxin-NADP+ reductase activity
J5285_00405	COG0583	DNA-binding transcription factor activity
J5285_00415	COG1902	pentaerythritol trinitrate reductase activity
J5285_00435	COG0387	Pfam Sodium calcium exchanger
J5285_00450	COG2199	diguanylate cyclase activity
J5285_00450	COG2200	EAL domain
J5285_00465	COG1278	Cold shock
J5285_00475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5285_00485	COG1846	Transcriptional regulator
J5285_00490	COG0745	RESPONSE REGULATOR receiver
J5285_00495	COG2205	protein histidine kinase activity
J5285_00500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5285_00520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J5285_00530	COG1496	oxidoreductase activity
J5285_00545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5285_00555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J5285_00560	COG1012	belongs to the aldehyde dehydrogenase family
J5285_00570	COG5001	Diguanylate cyclase
J5285_00570	COG3300	MHYT domain
J5285_00580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
J5285_00595	COG0193	aminoacyl-tRNA hydrolase activity
J5285_00620	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_00645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J5285_00650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
J5285_00650	COG2857	Cytochrome c1
J5285_00670	COG1132	(ABC) transporter
J5285_00675	COG0840	transmembrane signaling receptor activity
J5285_00680	COG1132	(ABC) transporter
J5285_00685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5285_00710	COG0408	coproporphyrinogen oxidase activity
J5285_00740	COG0714	Associated with various cellular activities
J5285_00760	COG0454	-acetyltransferase
J5285_00770	COG0477	Major facilitator Superfamily
J5285_00780	COG0435	Glutathione S-transferase
J5285_00785	COG0494	nUDIX hydrolase
J5285_00795	COG2801	Transposase and inactivated derivatives
J5285_00795	COG3415	Transposase
J5285_00800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5285_00810	COG3135	benzoate transporter
J5285_00825	COG0513	Belongs to the DEAD box helicase family
J5285_00830	COG5002	protein histidine kinase activity
J5285_00830	COG2205	protein histidine kinase activity
J5285_00830	COG0784	Response regulator, receiver
J5285_00835	COG2259	Doxx family
J5285_00845	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_00850	COG2308	Evidence 4 Homologs of previously reported genes of
J5285_00860	COG1305	Transglutaminase-like
J5285_00880	COG4214	carbohydrate transport
J5285_00890	COG4213	ABC transporter substrate-binding protein
J5285_00915	COG4213	ABC transporter substrate-binding protein
J5285_00920	COG4214	carbohydrate transport
J5285_00925	COG1129	ABC transporter
J5285_00975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5285_00980	COG2346	COG2346, Truncated hemoglobins
J5285_00995	COG1309	transcriptional regulator
J5285_01010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5285_01015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
J5285_01020	COG0830	nickel cation binding
J5285_01025	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
J5285_01040	COG0804	urea catabolic process
J5285_01045	COG3755	Protein conserved in bacteria
J5285_01055	COG0832	Belongs to the urease beta subunit family
J5285_01060	COG3813	Protein conserved in bacteria
J5285_01065	COG0831	urea catabolic process
J5285_01070	COG0829	nickel cation binding
J5285_01100	COG0559	Belongs to the binding-protein-dependent transport system permease family
J5285_01115	COG0174	glutamine synthetase
J5285_01120	COG5002	protein histidine kinase activity
J5285_01120	COG0784	Response regulator, receiver
J5285_01120	COG2198	Histidine kinase
J5285_01135	COG1660	Displays ATPase and GTPase activities
J5285_01170	COG1218	3'(2'),5'-bisphosphate nucleotidase
J5285_01240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5285_01250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J5285_01260	COG0564	pseudouridine synthase activity
J5285_01270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5285_01290	COG0740	serine-type endopeptidase activity
J5285_01300	COG3416	Protein conserved in bacteria
J5285_01305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J5285_01310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J5285_01330	COG3415	Transposase
J5285_01330	COG2801	Transposase and inactivated derivatives
J5285_01335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5285_01335	COG0512	Glutamine amidotransferase of anthranilate synthase
J5285_01355	COG2197	response regulator
J5285_01370	COG3794	PFAM blue (type 1) copper domain protein
J5285_01375	COG1435	thymidine kinase activity
J5285_01390	COG4175	Glycine betaine
J5285_01410	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J5285_01420	COG0366	Alpha amylase catalytic
J5285_01425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_01445	COG1160	GTP binding
J5285_01470	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
J5285_01475	COG0024	Methionine aminopeptidase
J5285_01490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5285_01495	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_01515	COG3657	addiction module killer protein
J5285_01520	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5285_01530	COG0583	DNA-binding transcription factor activity
J5285_01540	COG0402	S-adenosylhomocysteine deaminase activity
J5285_01545	COG0840	transmembrane signaling receptor activity
J5285_01550	COG1304	FMN binding
J5285_01555	COG1686	Belongs to the peptidase S11 family
J5285_01560	COG4115	mRNA cleavage
J5285_01575	COG2351	hydroxyisourate hydrolase activity
J5285_01580	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
J5285_01605	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
J5285_01610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J5285_01610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_01615	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
J5285_01615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_01625	COG0346	lactoylglutathione lyase activity
J5285_01645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
J5285_01655	COG2832	Protein of unknown function (DUF454)
J5285_01660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
J5285_01665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_01670	COG4558	Periplasmic binding protein
J5285_01680	COG3721	Heme iron utilization protein
J5285_01730	COG0783	Belongs to the Dps family
J5285_01750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J5285_01760	COG0482	sulfurtransferase activity
J5285_01780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5285_01795	COG5001	Diguanylate cyclase
J5285_01795	COG3300	MHYT domain
J5285_01800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5285_01805	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5285_01810	COG0037	tRNA processing
J5285_01820	COG2885	chlorophyll binding
J5285_01825	COG0823	Involved in the tonB-independent uptake of proteins
J5285_01845	COG0824	Thioesterase
J5285_01855	COG0494	nUDIX hydrolase
J5285_01870	COG1408	metallophosphoesterase
J5285_01875	COG2255	four-way junction helicase activity
J5285_01890	COG0632	four-way junction helicase activity
J5285_01895	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J5285_01900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_01910	COG0217	transcriptional regulatory protein
J5285_01925	COG1692	metallophosphoesterase
J5285_01935	COG1253	flavin adenine dinucleotide binding
J5285_01980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5285_01995	COG3263	regulation of cellular component size
J5285_02000	COG0126	phosphoglycerate kinase activity
J5285_02005	COG3588	fructose-bisphosphate aldolase
J5285_02040	COG0254	rRNA binding
J5285_02045	COG1132	(ABC) transporter
J5285_02055	COG0625	glutathione transferase activity
J5285_02060	COG0457	Tetratricopeptide repeat
J5285_02065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J5285_02070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5285_02075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J5285_02105	COG0483	inositol monophosphate 1-phosphatase activity
J5285_02125	COG3750	Belongs to the UPF0335 family
J5285_02145	COG0469	pyruvate kinase activity
J5285_02155	COG3108	Peptidase M15
J5285_02170	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5285_02180	COG5310	Homospermidine synthase
J5285_02190	COG0737	Belongs to the 5'-nucleotidase family
J5285_02220	COG0067	glutamate synthase
J5285_02220	COG0069	glutamate synthase activity
J5285_02220	COG0070	glutamate synthase
J5285_02230	COG1487	ribonuclease activity
J5285_02250	COG2951	lytic endotransglycosylase activity
J5285_02255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5285_02280	COG0330	HflC and HflK could
J5285_02285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
J5285_02290	COG0071	Belongs to the small heat shock protein (HSP20) family
J5285_02345	COG2308	Evidence 4 Homologs of previously reported genes of
J5285_02345	COG2307	Protein conserved in bacteria
J5285_02360	COG0058	SHG alpha-glucan phosphorylase activity
J5285_02365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5285_02370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J5285_02375	COG0297	glycogen (starch) synthase activity
J5285_02380	COG0033	Phosphoglucomutase
J5285_02410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5285_02410	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5285_02425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_02430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J5285_02460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J5285_02470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J5285_02475	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J5285_02480	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5285_02485	COG1609	Transcriptional regulator
J5285_02490	COG1846	Transcriptional regulator
J5285_02500	COG0523	cobalamin synthesis protein
J5285_02525	COG3047	cAMP biosynthetic process
J5285_02530	COG0840	transmembrane signaling receptor activity
J5285_02530	COG2972	Histidine kinase
J5285_02545	COG0583	DNA-binding transcription factor activity
J5285_02555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
J5285_02575	COG0800	Aldolase
J5285_02580	COG2954	triphosphatase activity
J5285_02590	COG1054	Belongs to the UPF0176 family
J5285_02600	COG1070	Carbohydrate kinase
J5285_02605	COG2115	Belongs to the xylose isomerase family
J5285_02610	COG2801	Transposase and inactivated derivatives
J5285_02610	COG3415	Transposase
J5285_02615	COG0778	Nitroreductase
J5285_02620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5285_02625	COG2011	ABC-type metal ion transport system permease component
J5285_02655	COG1253	flavin adenine dinucleotide binding
J5285_02665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5285_02670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J5285_02690	COG1121	(ABC) transporter
J5285_02695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5285_02700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5285_02705	COG5487	UPF0391 membrane protein
J5285_02710	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_02715	COG1414	Transcriptional regulator
J5285_02720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5285_02735	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
J5285_02740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5285_02765	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
J5285_02800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5285_02805	COG1309	transcriptional regulator
J5285_02815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5285_02825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J5285_02830	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J5285_02850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_02855	COG0725	ABC transporter, periplasmic molybdate-binding protein
J5285_02860	COG4149	molybdate abc transporter
J5285_02865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J5285_02870	COG3585	molybdate ion transport
J5285_02870	COG2005	Transcriptional regulator
J5285_02880	COG2022	thiamine diphosphate biosynthetic process
J5285_02895	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J5285_02900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5285_02910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5285_02925	COG1132	(ABC) transporter
J5285_02930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5285_02935	COG1234	tRNA 3'-trailer cleavage
J5285_02975	COG0747	negative chemotaxis
J5285_02985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_03025	COG0671	phosphoesterase, PA-phosphatase related
J5285_03030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
J5285_03035	COG3443	Belongs to the bacterial solute-binding protein 9 family
J5285_03040	COG0156	8-amino-7-oxononanoate synthase activity
J5285_03050	COG0729	surface antigen
J5285_03065	COG0835	chemotaxis
J5285_03075	COG2223	nitrite transmembrane transporter activity
J5285_03080	COG5002	protein histidine kinase activity
J5285_03085	COG2204	response regulator
J5285_03095	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J5285_03100	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J5285_03105	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J5285_03110	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J5285_03115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J5285_03120	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J5285_03135	COG4974	Belongs to the 'phage' integrase family
J5285_03145	COG3038	cytochrome b561
J5285_03165	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5285_03170	COG0567	Dehydrogenase, E1 component
J5285_03175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
J5285_03180	COG0045	succinate-CoA ligase (ADP-forming) activity
J5285_03185	COG0039	L-malate dehydrogenase activity
J5285_03190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J5285_03245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J5285_03250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
J5285_03255	COG0181	hydroxymethylbilane synthase activity
J5285_03300	COG1872	DUF167
J5285_03305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
J5285_03315	COG1217	gtp-binding protein TYPA
J5285_03320	COG0339	signal peptide processing
J5285_03335	COG0137	argininosuccinate synthase activity
J5285_03345	COG1280	lysine exporter protein (LysE YggA)
J5285_03350	COG1122	ATPase activity
J5285_03355	COG4120	Belongs to the binding-protein-dependent transport system permease family
J5285_03365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J5285_03380	COG2154	pterin-4-alpha-carbinolamine dehydratase
J5285_03385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5285_03390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
J5285_03400	COG4181	ATPase activity
J5285_03405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J5285_03410	COG0670	Belongs to the BI1 family
J5285_03425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5285_03430	COG4133	protoheme IX ABC transporter activity
J5285_03435	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5285_03440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
J5285_03460	COG2917	probably involved in intracellular septation
J5285_03465	COG0552	protein localization to endoplasmic reticulum
J5285_03470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5285_03475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
J5285_03480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J5285_03490	COG0765	amino acid transport
J5285_03500	COG0142	geranyltranstransferase activity
J5285_03505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5285_03515	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J5285_03525	COG0488	(ABC) transporter
J5285_03545	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J5285_03560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5285_03565	COG0287	Prephenate dehydrogenase
J5285_03565	COG1605	Chorismate mutase
J5285_03570	COG0228	four-way junction DNA binding
J5285_03575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J5285_03580	COG0336	Belongs to the RNA methyltransferase TrmD family
J5285_03590	COG0335	large ribosomal subunit rRNA binding
J5285_03595	COG2885	chlorophyll binding
J5285_03600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J5285_03605	COG0738	Major facilitator superfamily
J5285_03610	COG1349	DNA-binding transcription factor activity
J5285_03615	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
J5285_03620	COG2197	response regulator
J5285_03625	COG1132	(ABC) transporter
J5285_03635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5285_03640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5285_03645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5285_03650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
J5285_03660	COG2186	Transcriptional regulator
J5285_03665	COG0277	FAD linked oxidase domain protein
J5285_03670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5285_03675	COG2084	Dehydrogenase
J5285_03695	COG0579	oxidoreductase
J5285_03705	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
J5285_03710	COG1797	cobyrinic acid a,c-diamide synthase activity
J5285_03715	COG0625	glutathione transferase activity
J5285_03725	COG1858	cytochrome C peroxidase
J5285_03730	COG0473	3-isopropylmalate dehydrogenase activity
J5285_03735	COG0066	3-isopropylmalate dehydratase activity
J5285_03760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J5285_03765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J5285_03770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J5285_03780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J5285_03785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J5285_03790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J5285_03795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J5285_03800	COG0799	negative regulation of ribosome biogenesis
J5285_03805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J5285_03815	COG0793	Belongs to the peptidase S41A family
J5285_03825	COG0494	nUDIX hydrolase
J5285_03840	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_03845	COG0183	Belongs to the thiolase family
J5285_03855	COG2270	Major facilitator Superfamily
J5285_03860	COG2902	Dehydrogenase
J5285_03865	COG1329	Transcriptional regulator
J5285_03875	COG0745	RESPONSE REGULATOR receiver
J5285_03900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J5285_03905	COG1674	ftsk spoiiie
J5285_03910	COG0004	ammonium transporteR
J5285_03915	COG0347	Belongs to the P(II) protein family
J5285_03920	COG1946	Acyl-CoA thioesterase
J5285_03925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5285_03940	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J5285_03955	COG0495	leucyl-tRNA aminoacylation
J5285_03965	COG3459	Glycosyltransferase 36 associated
J5285_03970	COG1473	amidohydrolase
J5285_04035	COG1492	cobalamin metabolic process
J5285_04050	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_04055	COG1063	alcohol dehydrogenase
J5285_04075	COG4214	carbohydrate transport
J5285_04080	COG1129	ABC transporter
J5285_04090	COG2721	sulfolactate sulfo-lyase activity
J5285_04095	COG0138	bifunctional purine biosynthesis protein purh
J5285_04110	COG0501	Belongs to the peptidase M48B family
J5285_04130	COG0357	Ribosomal RNA small subunit methyltransferase G
J5285_04135	COG0445	tRNA wobble uridine modification
J5285_04140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J5285_04145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
J5285_04150	COG1981	membrane
J5285_04155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
J5285_04165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J5285_04170	COG0424	maF-like protein
J5285_04175	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5285_04180	COG0237	dephospho-CoA kinase activity
J5285_04190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
J5285_04230	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5285_04245	COG0135	phosphoribosylanthranilate isomerase activity
J5285_04250	COG0133	tryptophan synthase activity
J5285_04255	COG0159	tryptophan synthase activity
J5285_04260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J5285_04265	COG0285	dihydrofolate synthase activity
J5285_04285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J5285_04290	COG3178	'Phosphotransferase
J5285_04295	COG2205	protein histidine kinase activity
J5285_04300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5285_04305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5285_04310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5285_04310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J5285_04315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J5285_04320	COG0642	Histidine kinase
J5285_04325	COG0745	RESPONSE REGULATOR receiver
J5285_04330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J5285_04340	COG1072	(Pantothenic acid kinase))
J5285_04345	COG0140	phosphoribosyl-ATP diphosphatase activity
J5285_04350	COG0107	imidazoleglycerol-phosphate synthase activity
J5285_04355	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J5285_04360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5285_04370	COG0131	Imidazoleglycerol-phosphate dehydratase
J5285_04375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
J5285_04380	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
J5285_04390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5285_04405	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
J5285_04415	COG1643	Atp-dependent helicase
J5285_04455	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
J5285_04460	COG3454	Phosphonate metabolism
J5285_04465	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
J5285_04470	COG3639	organic phosphonate transmembrane transporter activity
J5285_04475	COG3639	organic phosphonate transmembrane transporter activity
J5285_04480	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
J5285_04485	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
J5285_04495	COG4778	phosphonate C-P lyase system protein PhnL
J5285_04500	COG4107	phosphonate C-P lyase system protein PhnK
J5285_04505	COG3627	carbon phosphorus lyase activity
J5285_04510	COG3626	phosphonate metabolism
J5285_04515	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
J5285_04520	COG3624	Phosphonate C-P lyase system protein PhnG
J5285_04525	COG2188	Transcriptional regulator
J5285_04535	COG0848	biopolymer transport protein
J5285_04545	COG2188	Transcriptional regulator
J5285_04550	COG1174	glycine betaine transport
J5285_04555	COG1125	glycine betaine transport
J5285_04560	COG1174	glycine betaine transport
J5285_04565	COG1732	Glycine betaine
J5285_04585	COG1959	2 iron, 2 sulfur cluster binding
J5285_04590	COG1840	ABC-type Fe3 transport system, periplasmic component
J5285_04615	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
J5285_04625	COG2986	histidine ammonia-lyase
J5285_04630	COG1228	amidohydrolase
J5285_04635	COG0402	S-adenosylhomocysteine deaminase activity
J5285_04640	COG0697	spore germination
J5285_04655	COG0791	NLP P60 protein
J5285_04665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J5285_04670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5285_04705	COG4964	Belongs to the GSP D family
J5285_04745	COG4251	negative regulation of phosphorylation
J5285_04750	COG4191	Histidine kinase
J5285_04750	COG0784	Response regulator, receiver
J5285_04755	COG0784	Response regulator, receiver
J5285_04760	COG0784	Response regulator, receiver
J5285_04760	COG4191	Histidine kinase
J5285_04770	COG1136	(ABC) transporter
J5285_04785	COG0443	Heat shock 70 kDa protein
J5285_04790	COG0484	heat shock protein binding
J5285_04800	COG2900	Belongs to the SlyX family
J5285_04830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J5285_04835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5285_04835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5285_04850	COG1278	Cold shock
J5285_04855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5285_04860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5285_04865	COG3757	hydrolase, family 25
J5285_04870	COG0697	spore germination
J5285_04875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5285_04895	COG0481	GTPase activity
J5285_04900	COG1605	Chorismate mutase
J5285_04900	COG0077	Prephenate dehydratase
J5285_04905	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
J5285_04910	COG3474	cytochrome
J5285_04930	COG2856	Zn peptidase
J5285_04945	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5285_04950	COG1744	ABC transporter substrate-binding protein PnrA-like
J5285_04955	COG3845	ABC transporter
J5285_04960	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5285_04965	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5285_04980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J5285_04985	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
J5285_04990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5285_05000	COG0756	dUTP diphosphatase activity
J5285_05005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J5285_05010	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5285_05020	COG2816	NAD+ diphosphatase activity
J5285_05035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5285_05040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J5285_05050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5285_05055	COG2951	lytic endotransglycosylase activity
J5285_05060	COG2814	Major facilitator Superfamily
J5285_05065	COG0779	Required for maturation of 30S ribosomal subunits
J5285_05070	COG0195	Participates in both transcription termination and antitermination
J5285_05070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5285_05080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J5285_05080	COG3064	Membrane
J5285_05085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J5285_05090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5285_05095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J5285_05105	COG1185	polyribonucleotide nucleotidyltransferase activity
J5285_05110	COG2813	Specifically methylates the guanine in position
J5285_05120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_05135	COG0456	acetyltransferase
J5285_05145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5285_05155	COG0572	uridine kinase
J5285_05180	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
J5285_05185	COG0588	phosphoglycerate mutase activity
J5285_05190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J5285_05195	COG1132	(ABC) transporter
J5285_05200	COG0837	glucose binding
J5285_05205	COG1803	Methylglyoxal synthase
J5285_05210	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
J5285_05215	COG4166	transmembrane transport
J5285_05220	COG4174	ABC transporter (Permease)
J5285_05225	COG4239	(ABC) transporter, permease
J5285_05240	COG4172	Belongs to the ABC transporter superfamily
J5285_05245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_05250	COG0174	glutamine synthetase
J5285_05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_05260	COG3265	gluconokinase activity
J5285_05285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5285_05295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5285_05300	COG3618	amidohydrolase
J5285_05320	COG0477	Major facilitator Superfamily
J5285_05325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5285_05330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5285_05335	COG1845	cytochrome c oxidase, subunit III
J5285_05340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J5285_05350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J5285_05355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5285_05360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J5285_05375	COG0640	Transcriptional regulator
J5285_05380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
J5285_05385	COG0268	Binds directly to 16S ribosomal RNA
J5285_05390	COG1024	Enoyl-CoA hydratase
J5285_05395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J5285_05400	COG2226	methyltransferase
J5285_05405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J5285_05415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5285_05420	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J5285_05425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
J5285_05430	COG1420	regulation of RNA biosynthetic process
J5285_05435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J5285_05440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5285_05445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J5285_05455	COG1137	ATPase activity
J5285_05460	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J5285_05470	COG0616	signal peptide processing
J5285_05475	COG0776	regulation of translation
J5285_05485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J5285_05490	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5285_05495	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J5285_05515	COG0583	DNA-binding transcription factor activity
J5285_05520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J5285_05525	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
J5285_05530	COG0728	peptidoglycan biosynthetic process
J5285_05535	COG0180	Tryptophanyl-tRNA synthetase
J5285_05545	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
J5285_05555	COG0456	acetyltransferase
J5285_05555	COG0454	-acetyltransferase
J5285_05570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J5285_05575	COG1702	phosphate starvation-inducible protein PhoH
J5285_05580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J5285_05585	COG1253	flavin adenine dinucleotide binding
J5285_05590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
J5285_05595	COG1396	sequence-specific DNA binding
J5285_05600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
J5285_05605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5285_05610	COG1349	DNA-binding transcription factor activity
J5285_05615	COG0494	nUDIX hydrolase
J5285_05620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_05630	COG0242	peptide deformylase activity
J5285_05635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J5285_05640	COG0101	tRNA pseudouridine synthase activity
J5285_05645	COG1393	Belongs to the ArsC family
J5285_05660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J5285_05665	COG2171	N-acyltransferase activity
J5285_05675	COG3415	Transposase
J5285_05675	COG2801	Transposase and inactivated derivatives
J5285_05680	COG1957	nucleoside hydrolase
J5285_05685	COG0071	Belongs to the small heat shock protein (HSP20) family
J5285_05710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J5285_05720	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J5285_05725	COG0706	membrane insertase activity
J5285_05730	COG0594	ribonuclease P activity
J5285_05735	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J5285_05740	COG0840	transmembrane signaling receptor activity
J5285_05765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5285_05790	COG3938	Belongs to the proline racemase family
J5285_05795	COG0418	dihydroorotase activity
J5285_05800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
J5285_05820	COG1823	symporter activity
J5285_05825	COG2207	Transcriptional regulator
J5285_05835	COG0166	Belongs to the GPI family
J5285_05840	COG0318	PFAM AMP-dependent synthetase and ligase
J5285_05845	COG3842	ATPase activity
J5285_05850	COG1840	ABC-type Fe3 transport system, periplasmic component
J5285_05860	COG4774	siderophore transport
J5285_05885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J5285_05900	COG1595	DNA-templated transcription, initiation
J5285_05905	COG3806	Anti-sigma factor
J5285_05920	COG3254	rhamnose metabolic process
J5285_05925	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_05935	COG1129	ABC transporter
J5285_05945	COG1349	DNA-binding transcription factor activity
J5285_05950	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_05950	COG3347	Dehydrogenase
J5285_05960	COG4952	isomerase
J5285_05970	COG3177	Filamentation induced by cAMP protein fic
J5285_05990	COG2326	polyphosphate kinase activity
J5285_05995	COG5002	protein histidine kinase activity
J5285_06000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J5285_06005	COG0573	inorganic phosphate transmembrane transporter activity
J5285_06015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5285_06020	COG0704	Plays a role in the regulation of phosphate uptake
J5285_06025	COG0745	RESPONSE REGULATOR receiver
J5285_06035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5285_06040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J5285_06055	COG2967	ApaG domain
J5285_06065	COG0717	Belongs to the dCTP deaminase family
J5285_06075	COG0582	viral genome integration into host DNA
J5285_06105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5285_06185	COG1132	(ABC) transporter
J5285_06220	COG0167	dihydroorotate dehydrogenase activity
J5285_06230	COG1201	RNA secondary structure unwinding
J5285_06240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J5285_06265	COG0730	response to heat
J5285_06275	COG1960	acyl-CoA dehydrogenase activity
J5285_06280	COG0183	Belongs to the thiolase family
J5285_06285	COG1024	Enoyl-CoA hydratase
J5285_06285	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5285_06355	COG4372	Transposase
J5285_06360	COG3436	PFAM IS66 Orf2 family protein
J5285_06365	COG2963	transposase activity
J5285_06380	COG0582	viral genome integration into host DNA
J5285_06400	COG3436	PFAM IS66 Orf2 family protein
J5285_06405	COG4372	Transposase
J5285_06410	COG3012	SEC-C Motif Domain Protein
J5285_06420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5285_06425	COG1215	transferase activity, transferring glycosyl groups
J5285_06445	COG0745	RESPONSE REGULATOR receiver
J5285_06450	COG2205	protein histidine kinase activity
J5285_06475	COG1320	monovalent cation:proton antiporter activity
J5285_06480	COG2212	antiporter activity
J5285_06485	COG1863	multisubunit Na H antiporter MnhE subunit
J5285_06490	COG0651	ATP synthesis coupled electron transport
J5285_06495	COG1006	Multisubunit Na H antiporter MnhC subunit
J5285_06500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5285_06500	COG2111	Na H antiporter
J5285_06510	COG0840	transmembrane signaling receptor activity
J5285_06520	COG0745	RESPONSE REGULATOR receiver
J5285_06525	COG0643	Histidine kinase
J5285_06525	COG2198	Histidine kinase
J5285_06530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J5285_06535	COG2201	protein-glutamate methylesterase activity
J5285_06540	COG0745	RESPONSE REGULATOR receiver
J5285_06545	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
J5285_06570	COG1766	The M ring may be actively involved in energy transduction
J5285_06575	COG2771	luxR family
J5285_06585	COG2972	Histidine kinase
J5285_06585	COG0840	transmembrane signaling receptor activity
J5285_06590	COG2205	protein histidine kinase activity
J5285_06590	COG0784	Response regulator, receiver
J5285_06590	COG2198	Histidine kinase
J5285_06595	COG1970	mechanosensitive ion channel activity
J5285_06600	COG0436	Aminotransferase
J5285_06610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J5285_06615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J5285_06620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J5285_06625	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
J5285_06630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
J5285_06635	COG4786	Flagellar basal body rod
J5285_06640	COG1157	protein secretion by the type III secretion system
J5285_06655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J5285_06660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J5285_06665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J5285_06670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
J5285_06680	COG1360	Flagellar Motor Protein
J5285_06705	COG1749	Flagellar hook protein flgE
J5285_06710	COG1256	bacterial-type flagellum assembly
J5285_06720	COG5442	Flagellar protein FlaF
J5285_06725	COG5443	negative regulation of bacterial-type flagellum assembly
J5285_06735	COG4794	Type iii secretion
J5285_06845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5285_06900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5285_06910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5285_06915	COG5328	Belongs to the UPF0262 family
J5285_06925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J5285_06930	COG0424	maF-like protein
J5285_06935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J5285_06945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
J5285_06975	COG1338	Plays a role in the flagellum-specific transport system
J5285_06985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
J5285_06995	COG1706	bacterial-type flagellum-dependent cell motility
J5285_07000	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
J5285_07005	COG4786	Flagellar basal body rod
J5285_07010	COG1677	Flagellar hook-basal body complex protein FliE
J5285_07015	COG1558	bacterial-type flagellum-dependent cell motility
J5285_07020	COG1815	bacterial-type flagellum-dependent cell motility
J5285_07030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J5285_07035	COG1609	Transcriptional regulator
J5285_07040	COG1653	transport
J5285_07045	COG1175	transmembrane transport
J5285_07050	COG0395	ABC-type sugar transport system, permease component
J5285_07055	COG0366	Alpha amylase catalytic
J5285_07060	COG3842	ATPase activity
J5285_07070	COG0129	dihydroxy-acid dehydratase activity
J5285_07075	COG0363	glucosamine-6-phosphate deaminase activity
J5285_07080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5285_07085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_07095	COG2081	HI0933 family
J5285_07125	COG3842	ATPase activity
J5285_07130	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_07135	COG1177	transmembrane transport
J5285_07140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5285_07150	COG2205	protein histidine kinase activity
J5285_07160	COG0248	Ppx GppA phosphatase
J5285_07165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
J5285_07170	COG0477	Major facilitator Superfamily
J5285_07190	COG0412	Dienelactone hydrolase
J5285_07195	COG0583	DNA-binding transcription factor activity
J5285_07205	COG0583	DNA-binding transcription factor activity
J5285_07225	COG0306	phosphate transporter
J5285_07235	COG0561	phosphatase activity
J5285_07240	COG0438	transferase activity, transferring glycosyl groups
J5285_07245	COG0583	DNA-binding transcription factor activity
J5285_07250	COG0277	FAD linked oxidase domain protein
J5285_07255	COG0277	FAD linked oxidase domain protein
J5285_07260	COG0247	lactate metabolic process
J5285_07265	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_07270	COG2818	Glycosylase
J5285_07280	COG2855	membrane
J5285_07285	COG0583	DNA-binding transcription factor activity
J5285_07315	COG0124	histidyl-tRNA synthetase
J5285_07320	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
J5285_07325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5285_07335	COG2259	Doxx family
J5285_07345	COG0459	protein refolding
J5285_07350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J5285_07365	COG0196	riboflavin kinase activity
J5285_07370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5285_07380	COG0590	tRNA wobble adenosine to inosine editing
J5285_07385	COG1187	pseudouridine synthase activity
J5285_07390	COG0742	ribosomal rna small subunit methyltransferase
J5285_07395	COG1752	Esterase of the alpha-beta hydrolase superfamily
J5285_07400	COG0312	modulator of DNA gyrase
J5285_07405	COG0483	inositol monophosphate 1-phosphatase activity
J5285_07415	COG1519	Transferase
J5285_07425	COG1663	tetraacyldisaccharide 4'-kinase activity
J5285_07435	COG3685	Protein conserved in bacteria
J5285_07445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J5285_07450	COG0784	Response regulator, receiver
J5285_07450	COG2198	Histidine kinase
J5285_07450	COG5002	protein histidine kinase activity
J5285_07455	COG3300	MHYT domain
J5285_07455	COG5001	Diguanylate cyclase
J5285_07460	COG3386	PFAM SMP-30 Gluconolaconase
J5285_07465	COG0800	Aldolase
J5285_07470	COG3734	2-keto-3-deoxy-galactonokinase
J5285_07475	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_07480	COG1414	Transcriptional regulator
J5285_07485	COG2197	response regulator
J5285_07505	COG3158	transport of potassium into the cell
J5285_07520	COG0356	it plays a direct role in the translocation of protons across the membrane
J5285_07530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5285_07535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J5285_07540	COG0840	transmembrane signaling receptor activity
J5285_07545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5285_07560	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5285_07565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J5285_07575	COG0142	geranyltranstransferase activity
J5285_07590	COG2827	Endonuclease containing a URI domain
J5285_07610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5285_07615	COG1704	LemA family
J5285_07620	COG0752	glycyl-tRNA synthetase alpha subunit
J5285_07625	COG0751	glycine-tRNA ligase activity
J5285_07640	COG1683	Conserved Protein
J5285_07645	COG0840	transmembrane signaling receptor activity
J5285_07655	COG0151	Belongs to the GarS family
J5285_07660	COG2183	response to ionizing radiation
J5285_07665	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J5285_07670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J5285_07685	COG0009	L-threonylcarbamoyladenylate synthase
J5285_07695	COG4638	Rieske (2fe-2S)
J5285_07720	COG1960	acyl-CoA dehydrogenase activity
J5285_07735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J5285_07745	COG0840	transmembrane signaling receptor activity
J5285_07760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5285_07770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J5285_07775	COG1741	Belongs to the pirin family
J5285_07785	COG1722	exodeoxyribonuclease VII activity
J5285_07790	COG0123	including yeast histone deacetylase and acetoin utilization protein
J5285_07795	COG1268	BioY protein
J5285_07800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J5285_07805	COG1122	ATPase activity
J5285_07810	COG3214	Protein conserved in bacteria
J5285_07820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J5285_07825	COG5001	Diguanylate cyclase
J5285_07840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J5285_07845	COG0484	heat shock protein binding
J5285_07855	COG0259	pyridoxamine-phosphate oxidase activity
J5285_07865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5285_07885	COG0312	modulator of DNA gyrase
J5285_07900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5285_07905	COG0109	protoheme IX farnesyltransferase activity
J5285_07910	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
J5285_07925	COG3346	SURF1 family
J5285_07930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J5285_07935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J5285_07940	COG0328	RNA-DNA hybrid ribonuclease activity
J5285_07950	COG3385	transposase activity
J5285_07955	COG0803	Belongs to the bacterial solute-binding protein 9 family
J5285_07960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5285_07970	COG0678	peroxiredoxin activity
J5285_07970	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5285_07980	COG1678	Uncharacterized ACR, COG1678
J5285_08000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J5285_08005	COG0612	Peptidase, M16
J5285_08025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5285_08035	COG1268	BioY protein
J5285_08050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
J5285_08075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5285_08080	COG1196	nuclear chromosome segregation
J5285_08085	COG0840	transmembrane signaling receptor activity
J5285_08105	COG2514	catechol 2,3-dioxygenase activity
J5285_08110	COG0574	Belongs to the PEP-utilizing enzyme family
J5285_08110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5285_08130	COG1487	ribonuclease activity
J5285_08150	COG0579	oxidoreductase
J5285_08175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J5285_08190	COG2895	sulfate adenylyltransferase (ATP) activity
J5285_08195	COG0175	sulfate reduction
J5285_08200	COG0175	sulfate reduction
J5285_08205	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J5285_08210	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J5285_08215	COG4208	sulfate ABC transporter
J5285_08220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J5285_08240	COG2203	Gaf domain
J5285_08240	COG2199	diguanylate cyclase activity
J5285_08240	COG2200	EAL domain
J5285_08250	COG1309	transcriptional regulator
J5285_08255	COG1012	belongs to the aldehyde dehydrogenase family
J5285_08260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
J5285_08295	COG5001	Diguanylate cyclase
J5285_08295	COG3300	MHYT domain
J5285_08310	COG0477	Major facilitator Superfamily
J5285_08320	COG1793	dna ligase
J5285_08330	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_08335	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_08350	COG3609	addiction module antidote protein, CC2985 family
J5285_08355	COG1846	Transcriptional regulator
J5285_08360	COG1764	response to oxidative stress
J5285_08400	COG0656	L-ascorbic acid biosynthetic process
J5285_08410	COG2378	regulation of single-species biofilm formation
J5285_08420	COG4106	trans-aconitate 2-methyltransferase activity
J5285_08425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5285_08450	COG0583	DNA-binding transcription factor activity
J5285_08470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J5285_08475	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
J5285_08480	COG1733	regulation of RNA biosynthetic process
J5285_08490	COG0433	COG0433 Predicted ATPase
J5285_08505	COG3909	cytochrome
J5285_08510	COG2010	Cytochrome c
J5285_08515	COG2972	Histidine kinase
J5285_08515	COG0840	transmembrane signaling receptor activity
J5285_08540	COG0456	acetyltransferase
J5285_08555	COG0789	Transcriptional regulator
J5285_08585	COG4176	ABC-type proline glycine betaine transport system permease component
J5285_08615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_08640	COG2514	catechol 2,3-dioxygenase activity
J5285_08650	COG1272	protein, Hemolysin III
J5285_08670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J5285_08675	COG2111	Na H antiporter
J5285_08675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5285_08680	COG2111	Na H antiporter
J5285_08685	COG1006	Multisubunit Na H antiporter MnhC subunit
J5285_08690	COG0651	ATP synthesis coupled electron transport
J5285_08695	COG1863	multisubunit Na H antiporter MnhE subunit
J5285_08700	COG2212	antiporter activity
J5285_08705	COG1320	monovalent cation:proton antiporter activity
J5285_08710	COG4957	zinc ion binding
J5285_08735	COG2166	iron-sulfur cluster assembly
J5285_08745	COG2205	protein histidine kinase activity
J5285_08755	COG2801	Transposase and inactivated derivatives
J5285_08755	COG3415	Transposase
J5285_08765	COG0835	chemotaxis
J5285_08770	COG0840	transmembrane signaling receptor activity
J5285_08810	COG3415	Transposase
J5285_08810	COG2801	Transposase and inactivated derivatives
J5285_08825	COG0583	DNA-binding transcription factor activity
J5285_08840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5285_08845	COG2983	Belongs to the UPF0260 family
J5285_08865	COG0789	Transcriptional regulator
J5285_08875	COG3077	Addiction module antitoxin, RelB DinJ family
J5285_08890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J5285_08910	COG1621	beta-fructofuranosidase activity
J5285_08960	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
J5285_08970	COG4695	Portal protein
J5285_09000	COG2801	Transposase and inactivated derivatives
J5285_09000	COG3415	Transposase
J5285_09085	COG4235	cytochrome complex assembly
J5285_09090	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
J5285_09095	COG1138	Cytochrome C-type biogenesis protein
J5285_09100	COG3088	subunit of a heme lyase
J5285_09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5285_09110	COG0745	RESPONSE REGULATOR receiver
J5285_09115	COG2205	protein histidine kinase activity
J5285_09120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5285_09135	COG1408	metallophosphoesterase
J5285_09140	COG2205	protein histidine kinase activity
J5285_09140	COG2202	Pas domain
J5285_09145	COG0308	aminopeptidase N
J5285_09150	COG0840	transmembrane signaling receptor activity
J5285_09180	COG0443	Heat shock 70 kDa protein
J5285_09205	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_09230	COG2944	sequence-specific DNA binding
J5285_09245	COG1733	regulation of RNA biosynthetic process
J5285_09255	COG1968	undecaprenyl-diphosphatase activity
J5285_09270	COG2239	Acts as a magnesium transporter
J5285_09275	COG2814	Major facilitator Superfamily
J5285_09295	COG0463	Glycosyl transferase, family 2
J5285_09315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J5285_09340	COG2382	esterase
J5285_09375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5285_09420	COG0741	lytic transglycosylase activity
J5285_09425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_09430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J5285_09440	COG5001	Diguanylate cyclase
J5285_09450	COG0840	transmembrane signaling receptor activity
J5285_09460	COG1758	RNA polymerase activity
J5285_09480	COG0736	holo-[acyl-carrier-protein] synthase activity
J5285_09485	COG0681	Belongs to the peptidase S26 family
J5285_09490	COG0571	ribonuclease III activity
J5285_09495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5285_09500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5285_09505	COG0784	Response regulator, receiver
J5285_09510	COG1381	Involved in DNA repair and RecF pathway recombination
J5285_09530	COG1418	mRNA catabolic process
J5285_09540	COG0346	lactoylglutathione lyase activity
J5285_09555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_09570	COG0668	transmembrane transport
J5285_09585	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
J5285_09610	COG0494	nUDIX hydrolase
J5285_09620	COG1742	UPF0060 membrane protein
J5285_09630	COG3706	GGDEF domain
J5285_09635	COG1183	phosphatidylcholine synthase activity
J5285_09640	COG0688	phosphatidylethanolamine metabolic process
J5285_09645	COG5265	(ABC) transporter
J5285_09650	COG1652	LysM domain
J5285_09685	COG2852	Protein conserved in bacteria
J5285_09695	COG0215	cysteine-tRNA ligase activity
J5285_09700	COG4221	oxidoreductase activity
J5285_09710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J5285_09715	COG1286	toxin biosynthetic process
J5285_09735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5285_09740	COG5265	(ABC) transporter
J5285_09775	COG0359	binds to the 23S rRNA
J5285_09785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J5285_09790	COG0360	Binds together with S18 to 16S ribosomal RNA
J5285_09805	COG0667	Aldo Keto reductase
J5285_09810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5285_09820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5285_09825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5285_09830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5285_09835	COG1561	YicC-like family, N-terminal region
J5285_09840	COG0194	GDP metabolic process
J5285_09845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J5285_09860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5285_09865	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J5285_09875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
J5285_09890	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
J5285_09910	COG0726	polysaccharide deacetylase
J5285_09920	COG0488	(ABC) transporter
J5285_09925	COG5002	protein histidine kinase activity
J5285_09925	COG3447	MASE1 domain protein
J5285_09925	COG5001	Diguanylate cyclase
J5285_09935	COG0105	UTP biosynthetic process
J5285_09975	COG0416	fatty acid biosynthetic process
J5285_09980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J5285_09985	COG0776	regulation of translation
J5285_10010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5285_10015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5285_10025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J5285_10030	COG0583	DNA-binding transcription factor activity
J5285_10045	COG2003	Belongs to the UPF0758 family
J5285_10050	COG0024	Methionine aminopeptidase
J5285_10055	COG1489	DNA binding
J5285_10060	COG3243	poly(R)-hydroxyalkanoic acid synthase
J5285_10085	COG1309	transcriptional regulator
J5285_10095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5285_10100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5285_10105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5285_10110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5285_10115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J5285_10150	COG0436	Aminotransferase
J5285_10170	COG0737	Belongs to the 5'-nucleotidase family
J5285_10190	COG2897	thiosulfate sulfurtransferase activity
J5285_10195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5285_10205	COG0415	Belongs to the DNA photolyase family
J5285_10250	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5285_10265	COG3932	Exopolysaccharide synthesis, ExoD
J5285_10270	COG1238	metal cluster binding
J5285_10295	COG4372	Transposase
J5285_10300	COG3436	PFAM IS66 Orf2 family protein
J5285_10305	COG2963	transposase activity
J5285_10340	COG1612	heme a metabolic process
J5285_10350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J5285_10355	COG0010	Belongs to the arginase family
J5285_10360	COG2755	lipolytic protein G-D-S-L family
J5285_10360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5285_10365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5285_10370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J5285_10380	COG1832	CoA-binding protein
J5285_10400	COG2124	cytochrome p450
J5285_10405	COG0405	Gamma-glutamyltransferase
J5285_10415	COG0740	serine-type endopeptidase activity
J5285_10420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J5285_10425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
J5285_10435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J5285_10440	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_10445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_10450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5285_10470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5285_10475	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5285_10480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5285_10490	COG0649	NAD binding
J5285_10500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
J5285_10505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5285_10515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
J5285_10520	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5285_10545	COG1007	ATP synthesis coupled electron transport
J5285_10560	COG0346	lactoylglutathione lyase activity
J5285_10570	COG0442	prolyl-tRNA aminoacylation
J5285_10580	COG1136	(ABC) transporter
J5285_10600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5285_10615	COG0784	Response regulator, receiver
J5285_10625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J5285_10645	COG0557	exoribonuclease II activity
J5285_10650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5285_10660	COG0758	DNA mediated transformation
J5285_10665	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J5285_10675	COG0540	Belongs to the ATCase OTCase family
J5285_10680	COG1960	acyl-CoA dehydrogenase activity
J5285_10705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5285_10710	COG2824	Alkylphosphonate utilization operon protein PhnA
J5285_10715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J5285_10725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5285_10730	COG0154	amidase activity
J5285_10735	COG0456	acetyltransferase
J5285_10755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5285_10760	COG0456	acetyltransferase
J5285_10780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J5285_10785	COG0439	Biotin carboxylase
J5285_10790	COG0511	ligase activity, forming carbon-carbon bonds
J5285_10795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J5285_10805	COG0436	Aminotransferase
J5285_10810	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_10815	COG3920	Histidine kinase
J5285_10820	COG0784	Response regulator, receiver
J5285_10820	COG4191	Histidine kinase
J5285_10825	COG0745	RESPONSE REGULATOR receiver
J5285_10835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5285_10850	COG1238	metal cluster binding
J5285_10860	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5285_10885	COG2267	carboxylic ester hydrolase activity
J5285_10900	COG0626	cystathionine gamma-synthase activity
J5285_10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_10910	COG4597	amino acid ABC transporter
J5285_10915	COG0765	amino acid transport
J5285_10920	COG1126	abc transporter atp-binding protein
J5285_10925	COG0589	response to stress
J5285_10930	COG1058	Belongs to the CinA family
J5285_10930	COG1546	Belongs to the CinA family
J5285_10935	COG0655	NAD(P)H dehydrogenase (quinone) activity
J5285_10960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J5285_10980	COG0633	Ferredoxin
J5285_10990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5285_10995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J5285_11000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5285_11010	COG3768	UPF0283 membrane protein
J5285_11015	COG3106	COG3106 Predicted ATPase
J5285_11040	COG1862	Preprotein translocase
J5285_11095	COG0544	peptidyl-prolyl cis-trans isomerase activity
J5285_11120	COG1368	sulfuric ester hydrolase activity
J5285_11130	COG0823	Involved in the tonB-independent uptake of proteins
J5285_11135	COG0778	Nitroreductase
J5285_11145	COG0280	phosphate acetyltransferase
J5285_11145	COG0281	malic enzyme
J5285_11155	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_11160	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J5285_11165	COG1127	ABC transporter
J5285_11175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J5285_11175	COG3218	ABC-type transport auxiliary lipoprotein component
J5285_11185	COG0372	Belongs to the citrate synthase family
J5285_11205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5285_11210	COG2877	3-deoxy-8-phosphooctulonate synthase activity
J5285_11215	COG0148	phosphopyruvate hydratase activity
J5285_11230	COG0785	Cytochrome C biogenesis protein
J5285_11235	COG0679	Auxin Efflux Carrier
J5285_11240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5285_11245	COG1183	phosphatidylcholine synthase activity
J5285_11250	COG3845	ABC transporter
J5285_11260	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5285_11280	COG0242	peptide deformylase activity
J5285_11290	COG0243	molybdopterin cofactor binding
J5285_11295	COG2239	Acts as a magnesium transporter
J5285_11310	COG3300	MHYT domain
J5285_11310	COG5001	Diguanylate cyclase
J5285_11330	COG3161	chorismate lyase activity
J5285_11385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J5285_11400	COG0667	Aldo Keto reductase
J5285_11410	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
J5285_11415	COG0187	DNA topoisomerase II activity
J5285_11425	COG0149	triose-phosphate isomerase activity
J5285_11435	COG0504	CTP synthase activity
J5285_11455	COG2197	response regulator
J5285_11460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J5285_11500	COG1278	Cold shock
J5285_11505	COG0346	lactoylglutathione lyase activity
J5285_11515	COG0517	IMP dehydrogenase activity
J5285_11515	COG1125	glycine betaine transport
J5285_11520	COG2095	MarC family integral membrane protein
J5285_11525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5285_11580	COG1864	DNA RNA non-specific endonuclease
J5285_11580	COG3591	Belongs to the peptidase S1B family
J5285_11585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J5285_11595	COG1671	Belongs to the UPF0178 family
J5285_11600	COG2197	response regulator
J5285_11605	COG3237	CsbD-like
J5285_11630	COG1686	Belongs to the peptidase S11 family
J5285_11635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J5285_11650	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5285_11655	COG0084	hydrolase, TatD family'
J5285_11660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J5285_11660	COG0321	lipoyl(octanoyl) transferase activity
J5285_11670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_11690	COG2814	Major facilitator Superfamily
J5285_11705	COG0546	phosphoglycolate phosphatase activity
J5285_11715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J5285_11745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5285_11750	COG0509	glycine decarboxylation via glycine cleavage system
J5285_11755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5285_11755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
J5285_11795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5285_11795	COG1648	precorrin-2 dehydrogenase activity
J5285_11805	COG3956	TIGRFAM MazG family protein
J5285_11815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5285_11820	COG1923	regulation of RNA biosynthetic process
J5285_11825	COG0569	domain protein
J5285_11830	COG2204	response regulator
J5285_11835	COG5000	phosphorelay sensor kinase activity
J5285_11840	COG2204	response regulator
J5285_11845	COG3852	Histidine kinase
J5285_11855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
J5285_11855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J5285_11885	COG2207	Transcriptional regulator
J5285_11890	COG0697	spore germination
J5285_11905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5285_11920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5285_11930	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5285_11935	COG0022	dehydrogenase e1 component
J5285_11935	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5285_11940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J5285_11955	COG0629	single-stranded DNA binding
J5285_11960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5285_11975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5285_12000	COG3609	addiction module antidote protein, CC2985 family
J5285_12010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5285_12015	COG1121	(ABC) transporter
J5285_12025	COG0523	cobalamin synthesis protein
J5285_12030	COG1132	(ABC) transporter
J5285_12035	COG0628	permease
J5285_12075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J5285_12085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J5285_12095	COG0302	gtp cyclohydrolase
J5285_12100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5285_12105	COG1752	Esterase of the alpha-beta hydrolase superfamily
J5285_12145	COG1760	l-serine dehydratase
J5285_12170	COG0583	DNA-binding transcription factor activity
J5285_12185	COG0745	RESPONSE REGULATOR receiver
J5285_12195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J5285_12195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J5285_12200	COG0347	Belongs to the P(II) protein family
J5285_12205	COG0174	glutamine synthetase
J5285_12230	COG0697	spore germination
J5285_12240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5285_12250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J5285_12260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5285_12260	COG0512	Glutamine amidotransferase of anthranilate synthase
J5285_12265	COG0343	queuine tRNA-ribosyltransferase activity
J5285_12270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J5285_12285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J5285_12305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5285_12310	COG0134	indole-3-glycerol-phosphate synthase activity
J5285_12315	COG0315	cyclic pyranopterin monophosphate synthase activity
J5285_12320	COG0303	'Molybdopterin
J5285_12335	COG3264	Mechanosensitive ion channel
J5285_12335	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
J5285_12370	COG0384	phenazine biosynthesis protein PhzF
J5285_12375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5285_12395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
J5285_12405	COG1530	ribonuclease E activity
J5285_12420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5285_12425	COG3494	Protein of unknown function (DUF1009)
J5285_12430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5285_12435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J5285_12440	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5285_12445	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5285_12450	COG0750	zinc metalloprotease
J5285_12460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5285_12465	COG0233	cytoplasmic translational termination
J5285_12470	COG0528	UMP kinase activity
J5285_12475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J5285_12480	COG0052	Belongs to the universal ribosomal protein uS2 family
J5285_12505	COG0537	adenosine 5'-monophosphoramidase activity
J5285_12540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_12545	COG0577	efflux transmembrane transporter activity
J5285_12545	COG1136	(ABC) transporter
J5285_12550	COG0577	efflux transmembrane transporter activity
J5285_12550	COG1136	(ABC) transporter
J5285_12555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5285_12565	COG0316	Belongs to the HesB IscA family
J5285_12570	COG2151	metal-sulfur cluster biosynthetic enzyme
J5285_12575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5285_12580	COG0719	Fe-S assembly protein
J5285_12585	COG0396	ATPase activity
J5285_12590	COG0719	Fe-S assembly protein
J5285_12595	COG1104	cysteine desulfurase activity
J5285_12600	COG2945	thiolester hydrolase activity
J5285_12615	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J5285_12620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5285_12635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5285_12645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5285_12675	COG2814	Major facilitator Superfamily
J5285_12680	COG0483	inositol monophosphate 1-phosphatase activity
J5285_12685	COG0483	inositol monophosphate 1-phosphatase activity
J5285_12690	COG0037	tRNA processing
J5285_12695	COG2066	Belongs to the glutaminase family
J5285_12700	COG2989	Protein conserved in bacteria
J5285_12705	COG0114	fumarate hydratase activity
J5285_12710	COG3706	GGDEF domain
J5285_12720	COG0475	glutathione-regulated potassium exporter activity
J5285_12720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5285_12730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J5285_12735	COG0697	spore germination
J5285_12740	COG2814	Major facilitator Superfamily
J5285_12745	COG0746	molybdenum cofactor guanylyltransferase activity
J5285_12750	COG1763	Mo-molybdopterin cofactor biosynthetic process
J5285_12760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J5285_12765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J5285_12770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J5285_12775	COG0805	protein transport
J5285_12780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5285_12785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J5285_12790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J5285_12795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J5285_12800	COG1472	Belongs to the glycosyl hydrolase 3 family
J5285_12810	COG0018	arginyl-trna synthetase
J5285_12815	COG0232	Belongs to the dGTPase family. Type 2 subfamily
J5285_12820	COG0316	Belongs to the HesB IscA family
J5285_12850	COG0525	valine-tRNA ligase activity
J5285_12860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J5285_12865	COG0739	heme binding
J5285_12870	COG0513	Belongs to the DEAD box helicase family
J5285_12890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5285_12905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J5285_12910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5285_12915	COG0047	phosphoribosylformylglycinamidine synthase activity
J5285_12930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5285_12940	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
J5285_12950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5285_12955	COG2852	Protein conserved in bacteria
J5285_12960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
J5285_12975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J5285_12980	COG0546	phosphoglycolate phosphatase activity
J5285_12985	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J5285_12990	COG0861	Integral membrane protein TerC family
J5285_13010	COG1280	lysine exporter protein (LysE YggA)
J5285_13025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5285_13030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
J5285_13040	COG0538	isocitrate dehydrogenase activity
J5285_13060	COG0321	lipoyl(octanoyl) transferase activity
J5285_13075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J5285_13080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J5285_13085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_13090	COG2313	pseudouridylate synthase activity
J5285_13105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_13120	COG5425	PFAM Usg family protein
J5285_13130	COG1522	sequence-specific DNA binding
J5285_13135	COG1573	uracil-dna glycosylase
J5285_13145	COG2205	protein histidine kinase activity
J5285_13145	COG2202	Pas domain
J5285_13150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J5285_13155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
J5285_13160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
J5285_13185	COG0842	Transport permease protein
J5285_13190	COG1131	(ABC) transporter
J5285_13215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5285_13220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5285_13255	COG0129	dihydroxy-acid dehydratase activity
J5285_13265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5285_13270	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J5285_13275	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
J5285_13305	COG0203	ribosomal protein L17
J5285_13310	COG0202	RNA polymerase activity
J5285_13315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J5285_13320	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J5285_13325	COG0563	adenylate kinase activity
J5285_13330	COG0201	protein transport
J5285_13335	COG0200	Binds to the 23S rRNA
J5285_13340	COG1841	ribosomal large subunit assembly
J5285_13345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J5285_13350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J5285_13355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J5285_13360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J5285_13365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J5285_13370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J5285_13375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J5285_13380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J5285_13385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J5285_13390	COG0255	Belongs to the universal ribosomal protein uL29 family
J5285_13395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J5285_13400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J5285_13405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J5285_13410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J5285_13415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J5285_13420	COG0089	rRNA binding
J5285_13425	COG0088	Forms part of the polypeptide exit tunnel
J5285_13430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J5285_13435	COG0051	transcription antitermination factor activity, RNA binding
J5285_13440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5285_13445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J5285_13450	COG0049	tRNA binding
J5285_13455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J5285_13485	COG0583	DNA-binding transcription factor activity
J5285_13495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J5285_13500	COG0085	RNA polymerase activity
J5285_13505	COG0222	ribosome binding
J5285_13510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J5285_13515	COG0081	regulation of translation
J5285_13520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J5285_13530	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J5285_13550	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J5285_13555	COG0861	Integral membrane protein TerC family
J5285_13580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5285_13630	COG0556	nucleotide-excision repair
J5285_13635	COG2382	esterase
J5285_13655	COG0484	heat shock protein binding
J5285_13700	COG0384	phenazine biosynthesis protein PhzF
J5285_13705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5285_13720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J5285_13730	COG1733	regulation of RNA biosynthetic process
J5285_13735	COG0702	epimerase
J5285_13740	COG2207	Transcriptional regulator
J5285_13745	COG1064	alcohol dehydrogenase
J5285_13750	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5285_13755	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J5285_13765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5285_13770	COG0840	transmembrane signaling receptor activity
J5285_13780	COG0656	L-ascorbic acid biosynthetic process
J5285_13785	COG0840	transmembrane signaling receptor activity
J5285_13795	COG0440	acetolactate synthase activity
J5285_13800	COG0028	Belongs to the TPP enzyme family
J5285_13810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J5285_13815	COG0560	Phosphoserine phosphatase
J5285_13825	COG1116	anion transmembrane transporter activity
J5285_13835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_13840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_13865	COG0330	HflC and HflK could
J5285_13870	COG0330	HflC and HflK could
J5285_13880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5285_13935	COG0277	FAD linked oxidase domain protein
J5285_13945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_13980	COG1335	isochorismatase
J5285_14000	COG0006	proline dipeptidase activity
J5285_14010	COG2264	protein methyltransferase activity
J5285_14030	COG0835	chemotaxis
J5285_14050	COG0697	spore germination
J5285_14055	COG1247	-acetyltransferase
J5285_14060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J5285_14075	COG1280	lysine exporter protein (LysE YggA)
J5285_14085	COG0497	DNA recombination
J5285_14090	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5285_14100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5285_14105	COG0849	cell division
J5285_14110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J5285_14115	COG1181	Belongs to the D-alanine--D-alanine ligase family
J5285_14135	COG0477	Major facilitator Superfamily
J5285_14140	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J5285_14145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5285_14150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J5285_14160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J5285_14165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5285_14175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5285_14190	COG0275	rRNA processing
J5285_14195	COG2001	Belongs to the MraZ family
J5285_14245	COG3023	N-Acetylmuramoyl-L-alanine amidase
J5285_14270	COG3734	2-keto-3-deoxy-galactonokinase
J5285_14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_14280	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_14290	COG1175	transmembrane transport
J5285_14295	COG0395	ABC-type sugar transport system, permease component
J5285_14305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5285_14315	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_14325	COG0747	negative chemotaxis
J5285_14330	COG0747	negative chemotaxis
J5285_14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_14345	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_14350	COG0726	polysaccharide deacetylase
J5285_14360	COG0444	Belongs to the ABC transporter superfamily
J5285_14370	COG1473	amidohydrolase
J5285_14380	COG1396	sequence-specific DNA binding
J5285_14425	COG1940	carbohydrate kinase activity
J5285_14435	COG3842	ATPase activity
J5285_14440	COG0395	ABC-type sugar transport system, permease component
J5285_14455	COG4106	trans-aconitate 2-methyltransferase activity
J5285_14460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_14465	COG1126	abc transporter atp-binding protein
J5285_14470	COG0765	amino acid transport
J5285_14485	COG1522	sequence-specific DNA binding
J5285_14490	COG0583	DNA-binding transcription factor activity
J5285_14495	COG0028	Belongs to the TPP enzyme family
J5285_14500	COG4774	siderophore transport
J5285_14510	COG1120	ATPase activity
J5285_14525	COG1802	Transcriptional regulator
J5285_14530	COG0747	negative chemotaxis
J5285_14535	COG0601	transmembrane transport
J5285_14540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_14550	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_14555	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_14560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
J5285_14565	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_14565	COG3321	synthase
J5285_14565	COG0604	alcohol dehydrogenase
J5285_14575	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
J5285_14580	COG3012	SEC-C Motif Domain Protein
J5285_14585	COG4372	Transposase
J5285_14590	COG3436	PFAM IS66 Orf2 family protein
J5285_14600	COG1368	sulfuric ester hydrolase activity
J5285_14635	COG1086	Polysaccharide biosynthesis protein
J5285_14640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5285_14645	COG1083	cytidylyl-transferase
J5285_14655	COG2089	acid synthase
J5285_14665	COG2226	methyltransferase
J5285_14675	COG3436	PFAM IS66 Orf2 family protein
J5285_14680	COG4372	Transposase
J5285_14685	COG3012	SEC-C Motif Domain Protein
J5285_14700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5285_14740	COG1609	Transcriptional regulator
J5285_14765	COG0640	Transcriptional regulator
J5285_14780	COG3177	Filamentation induced by cAMP protein fic
J5285_14815	COG1278	Cold shock
J5285_14835	COG0475	glutathione-regulated potassium exporter activity
J5285_14850	COG0745	RESPONSE REGULATOR receiver
J5285_14890	COG1959	2 iron, 2 sulfur cluster binding
J5285_14940	COG4372	Transposase
J5285_14945	COG3436	PFAM IS66 Orf2 family protein
J5285_14950	COG2963	transposase activity
J5285_15080	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5285_15105	COG3335	DDE superfamily endonuclease
J5285_15110	COG3335	DDE superfamily endonuclease
J5285_15135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5285_15210	COG0745	RESPONSE REGULATOR receiver
J5285_15225	COG0475	glutathione-regulated potassium exporter activity
J5285_15235	COG4372	Transposase
J5285_15245	COG2963	transposase activity
J5285_15255	COG2207	Transcriptional regulator
J5285_15270	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_15280	COG1802	Transcriptional regulator
J5285_15285	COG0747	negative chemotaxis
J5285_15290	COG0601	transmembrane transport
J5285_15295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_15315	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_15335	COG5002	protein histidine kinase activity
J5285_15345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J5285_15365	COG3920	Histidine kinase
J5285_15370	COG0784	Response regulator, receiver
J5285_15370	COG4191	Histidine kinase
J5285_15385	COG1487	ribonuclease activity
J5285_15390	COG4691	Plasmid stability protein
J5285_15405	COG1780	Probably involved in ribonucleotide reductase function
J5285_15410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5285_15420	COG1120	ATPase activity
J5285_15425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_15430	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_15445	COG3920	Histidine kinase
J5285_15445	COG2202	Pas domain
J5285_15450	COG0784	Response regulator, receiver
J5285_15455	COG0784	Response regulator, receiver
J5285_15455	COG4191	Histidine kinase
J5285_15460	COG4191	Histidine kinase
J5285_15460	COG0784	Response regulator, receiver
J5285_15465	COG0628	permease
J5285_15470	COG5001	Diguanylate cyclase
J5285_15480	COG0840	transmembrane signaling receptor activity
J5285_15490	COG1733	regulation of RNA biosynthetic process
J5285_15500	COG3387	PFAM Glycoside hydrolase 15-related
J5285_15505	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_15510	COG3386	PFAM SMP-30 Gluconolaconase
J5285_15530	COG1595	DNA-templated transcription, initiation
J5285_15565	COG3077	Addiction module antitoxin, RelB DinJ family
J5285_15585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5285_15585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J5285_15615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5285_15620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5285_15625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J5285_15630	COG2080	2 iron, 2 sulfur cluster binding
J5285_15635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J5285_15640	COG1309	transcriptional regulator
J5285_15650	COG3842	ATPase activity
J5285_15660	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_15690	COG4172	Belongs to the ABC transporter superfamily
J5285_15695	COG1921	L-seryl-tRNASec selenium transferase activity
J5285_15710	COG3964	amidohydrolase
J5285_15720	COG0601	transmembrane transport
J5285_15725	COG0747	negative chemotaxis
J5285_15730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5285_15730	COG3453	Protein conserved in bacteria
J5285_15735	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5285_15735	COG0515	serine threonine protein kinase
J5285_15745	COG0747	negative chemotaxis
J5285_15750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_15755	COG0601	transmembrane transport
J5285_15770	COG4172	Belongs to the ABC transporter superfamily
J5285_15775	COG1802	Transcriptional regulator
J5285_15785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J5285_15800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J5285_15820	COG3842	ATPase activity
J5285_15830	COG1175	transmembrane transport
J5285_15845	COG0673	inositol 2-dehydrogenase activity
J5285_15850	COG1609	Transcriptional regulator
J5285_15865	COG0583	DNA-binding transcription factor activity
J5285_15880	COG1177	transmembrane transport
J5285_15885	COG3842	ATPase activity
J5285_15890	COG2072	flavoprotein involved in K transport
J5285_15925	COG2017	converts alpha-aldose to the beta-anomer
J5285_15930	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_15935	COG4172	Belongs to the ABC transporter superfamily
J5285_15940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_15945	COG0601	transmembrane transport
J5285_15950	COG0747	negative chemotaxis
J5285_15965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_15970	COG0514	ATP-dependent DNA helicase (RecQ)
J5285_15980	COG0110	maltose O-acetyltransferase activity
J5285_16000	COG3842	ATPase activity
J5285_16010	COG0395	ABC-type sugar transport system, permease component
J5285_16015	COG1175	transmembrane transport
J5285_16030	COG2186	Transcriptional regulator
J5285_16040	COG4172	Belongs to the ABC transporter superfamily
J5285_16045	COG0405	Gamma-glutamyltransferase
J5285_16050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_16055	COG0601	transmembrane transport
J5285_16060	COG0747	negative chemotaxis
J5285_16065	COG2188	Transcriptional regulator
J5285_16070	COG0577	efflux transmembrane transporter activity
J5285_16070	COG1136	(ABC) transporter
J5285_16075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_16190	COG0515	serine threonine protein kinase
J5285_16200	COG3300	MHYT domain
J5285_16200	COG5001	Diguanylate cyclase
J5285_16210	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J5285_16215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
J5285_16220	COG4770	biotin carboxylase activity
J5285_16230	COG0747	negative chemotaxis
J5285_16240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_16255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_16260	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
J5285_16265	COG4172	Belongs to the ABC transporter superfamily
J5285_16270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_16275	COG0601	transmembrane transport
J5285_16280	COG4166	transmembrane transport
J5285_16295	COG3842	ATPase activity
J5285_16300	COG3842	ATPase activity
J5285_16310	COG0395	ABC-type sugar transport system, permease component
J5285_16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_16330	COG4175	Glycine betaine
J5285_16330	COG0517	IMP dehydrogenase activity
J5285_16335	COG4176	ABC-type proline glycine betaine transport system permease component
J5285_16350	COG0450	alkyl hydroperoxide reductase
J5285_16355	COG0488	(ABC) transporter
J5285_16360	COG3706	GGDEF domain
J5285_16370	COG1120	ATPase activity
J5285_16380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
J5285_16405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5285_16420	COG0297	glycogen (starch) synthase activity
J5285_16430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5285_16440	COG4529	Protein conserved in bacteria
J5285_16460	COG0577	efflux transmembrane transporter activity
J5285_16490	COG2197	response regulator
J5285_16535	COG0129	dihydroxy-acid dehydratase activity
J5285_16540	COG1879	ABC-type sugar transport system periplasmic component
J5285_16545	COG1129	ABC transporter
J5285_16550	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_16555	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_16560	COG2186	Transcriptional regulator
J5285_16565	COG0587	DNA-directed DNA polymerase activity
J5285_16580	COG3307	-O-antigen
J5285_16585	COG1596	polysaccharide export
J5285_16595	COG0693	protein deglycase activity
J5285_16610	COG3485	protocatechuate 3,4-dioxygenase
J5285_16615	COG3485	protocatechuate 3,4-dioxygenase
J5285_16620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5285_16630	COG0583	DNA-binding transcription factor activity
J5285_16645	COG1414	Transcriptional regulator
J5285_16655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5285_16660	COG0183	Belongs to the thiolase family
J5285_16675	COG5001	Diguanylate cyclase
J5285_16680	COG0683	leucine binding
J5285_16705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
J5285_16720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5285_16725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
J5285_16760	COG1960	acyl-CoA dehydrogenase activity
J5285_16775	COG1024	Enoyl-CoA hydratase
J5285_16790	COG1082	Xylose isomerase domain protein TIM barrel
J5285_16790	COG3185	4-Hydroxyphenylpyruvate dioxygenase
J5285_16800	COG1940	carbohydrate kinase activity
J5285_16805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
J5285_16810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5285_16815	COG2188	Transcriptional regulator
J5285_16825	COG1175	transmembrane transport
J5285_16830	COG0395	ABC-type sugar transport system, permease component
J5285_16840	COG3842	ATPase activity
J5285_16855	COG0251	oxidation-reduction process
J5285_16860	COG1737	Transcriptional regulator
J5285_16865	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_16885	COG3142	Participates in the control of copper homeostasis
J5285_16890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5285_16910	COG2203	Gaf domain
J5285_16910	COG3706	GGDEF domain
J5285_16910	COG4251	negative regulation of phosphorylation
J5285_16910	COG5001	Diguanylate cyclase
J5285_16920	COG2897	thiosulfate sulfurtransferase activity
J5285_16925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_16940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_16945	COG1126	abc transporter atp-binding protein
J5285_16955	COG1473	amidohydrolase
J5285_16960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_16965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_16975	COG1312	Catalyzes the dehydration of D-mannonate
J5285_16985	COG3842	ATPase activity
J5285_16990	COG0395	ABC-type sugar transport system, permease component
J5285_16995	COG1175	transmembrane transport
J5285_17000	COG1653	transport
J5285_17005	COG2017	converts alpha-aldose to the beta-anomer
J5285_17045	COG1116	anion transmembrane transporter activity
J5285_17050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_17055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_17060	COG1464	Belongs to the NlpA lipoprotein family
J5285_17070	COG2011	ABC-type metal ion transport system permease component
J5285_17085	COG1737	Transcriptional regulator
J5285_17090	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_17095	COG1129	ABC transporter
J5285_17115	COG0395	ABC-type sugar transport system, permease component
J5285_17120	COG1175	transmembrane transport
J5285_17130	COG3842	ATPase activity
J5285_17150	COG1879	ABC-type sugar transport system periplasmic component
J5285_17155	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_17160	COG2376	Dihydroxyacetone kinase
J5285_17170	COG2376	Dihydroxyacetone kinase
J5285_17175	COG1461	Dihydroxyacetone kinase
J5285_17190	COG0747	negative chemotaxis
J5285_17210	COG4608	Belongs to the ABC transporter superfamily
J5285_17215	COG0667	Aldo Keto reductase
J5285_17225	COG0583	DNA-binding transcription factor activity
J5285_17230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_17250	COG1473	amidohydrolase
J5285_17255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_17270	COG0778	Nitroreductase
J5285_17290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_17300	COG1116	anion transmembrane transporter activity
J5285_17305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_17310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_17320	COG0747	negative chemotaxis
J5285_17325	COG0601	transmembrane transport
J5285_17335	COG0444	Belongs to the ABC transporter superfamily
J5285_17350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_17355	COG1116	anion transmembrane transporter activity
J5285_17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_17365	COG2814	Major facilitator Superfamily
J5285_17370	COG0667	Aldo Keto reductase
J5285_17375	COG0583	DNA-binding transcription factor activity
J5285_17435	COG1653	transport
J5285_17440	COG1175	transmembrane transport
J5285_17445	COG0395	ABC-type sugar transport system, permease component
J5285_17465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5285_17470	COG0789	Transcriptional regulator
J5285_17490	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_17500	COG1879	ABC-type sugar transport system periplasmic component
J5285_17505	COG2207	Transcriptional regulator
J5285_17505	COG3708	Transcriptional regulator
J5285_17515	COG1063	alcohol dehydrogenase
J5285_17520	COG0583	DNA-binding transcription factor activity
J5285_17525	COG0657	acetylesterase activity
J5285_17530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_17540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J5285_17550	COG0025	NhaP-type Na H and K H
J5285_17555	COG2223	nitrite transmembrane transporter activity
J5285_17570	COG2273	Hydrolase Family 16
J5285_17570	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
J5285_17580	COG3257	ureidoglycine aminohydrolase activity
J5285_17590	COG3300	MHYT domain
J5285_17590	COG5001	Diguanylate cyclase
J5285_17595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_17600	COG3842	ATPase activity
J5285_17605	COG3833	ABC-type maltose transport systems, permease component
J5285_17610	COG1175	transmembrane transport
J5285_17625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_17635	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
J5285_17640	COG2814	Major facilitator Superfamily
J5285_17645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5285_17650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
J5285_17655	COG1280	lysine exporter protein (LysE YggA)
J5285_17665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5285_17665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5285_17670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J5285_17675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
J5285_17695	COG0113	porphobilinogen synthase activity
J5285_17705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
J5285_17720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J5285_17730	COG0659	secondary active sulfate transmembrane transporter activity
J5285_17740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J5285_17745	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J5285_17750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
J5285_17760	COG1285	pathogenesis
J5285_17765	COG0248	Ppx GppA phosphatase
J5285_17770	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
J5285_17780	COG0628	permease
J5285_17785	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J5285_17790	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5285_17805	COG0494	nUDIX hydrolase
J5285_17810	COG0243	molybdopterin cofactor binding
J5285_17815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J5285_17830	COG0625	glutathione transferase activity
J5285_17845	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_17850	COG0322	excinuclease ABC activity
J5285_17855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5285_17865	COG0314	molybdopterin synthase activity
J5285_17875	COG2217	Heavy metal translocating P-type atpase
J5285_17880	COG0697	spore germination
J5285_17885	COG2423	ornithine cyclodeaminase activity
J5285_17890	COG0010	Belongs to the arginase family
J5285_17905	COG1082	Xylose isomerase domain protein TIM barrel
J5285_17910	COG3842	ATPase activity
J5285_17920	COG0395	ABC-type sugar transport system, permease component
J5285_17940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J5285_17945	COG0406	alpha-ribazole phosphatase activity
J5285_17950	COG2205	protein histidine kinase activity
J5285_17955	COG0745	RESPONSE REGULATOR receiver
J5285_17960	COG3210	domain, Protein
J5285_17990	COG1012	belongs to the aldehyde dehydrogenase family
J5285_18020	COG0559	Belongs to the binding-protein-dependent transport system permease family
J5285_18030	COG1024	Enoyl-CoA hydratase
J5285_18035	COG2050	protein possibly involved in aromatic compounds catabolism
J5285_18045	COG1309	transcriptional regulator
J5285_18055	COG1012	belongs to the aldehyde dehydrogenase family
J5285_18055	COG2030	dehydratase
J5285_18060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5285_18065	COG2151	metal-sulfur cluster biosynthetic enzyme
J5285_18070	COG3396	Phenylacetate-CoA oxygenase
J5285_18075	COG3460	Phenylacetate-CoA oxygenase
J5285_18080	COG3396	Phenylacetate-CoA oxygenase
J5285_18085	COG0183	Belongs to the thiolase family
J5285_18095	COG0598	Magnesium transport protein CorA
J5285_18110	COG1278	Cold shock
J5285_18115	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J5285_18125	COG4191	Histidine kinase
J5285_18125	COG0784	Response regulator, receiver
J5285_18150	COG4702	Belongs to the UPF0303 family
J5285_18170	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
J5285_18175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_18180	COG0765	amino acid transport
J5285_18185	COG1126	abc transporter atp-binding protein
J5285_18195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_18200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5285_18205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5285_18220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J5285_18225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
J5285_18235	COG3119	arylsulfatase activity
J5285_18245	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
J5285_18255	COG2390	Transcriptional regulator
J5285_18260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5285_18265	COG3958	Transketolase
J5285_18270	COG3959	Transketolase, thiamine diphosphate binding domain
J5285_18275	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_18285	COG1129	ABC transporter
J5285_18290	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_18300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5285_18305	COG2226	methyltransferase
J5285_18310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J5285_18315	COG0287	Prephenate dehydrogenase
J5285_18320	COG0523	cobalamin synthesis protein
J5285_18325	COG1686	Belongs to the peptidase S11 family
J5285_18330	COG1473	amidohydrolase
J5285_18360	COG0392	lysyltransferase activity
J5285_18360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
J5285_18370	COG0006	proline dipeptidase activity
J5285_18385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_18390	COG0601	transmembrane transport
J5285_18395	COG0747	negative chemotaxis
J5285_18405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
J5285_18410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_18415	COG1454	alcohol dehydrogenase
J5285_18420	COG3395	kinase activity
J5285_18435	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J5285_18440	COG0352	thiamine-phosphate diphosphorylase activity
J5285_18445	COG0351	phosphomethylpyrimidine kinase
J5285_18450	COG1522	sequence-specific DNA binding
J5285_18455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5285_18460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_18470	COG2204	response regulator
J5285_18475	COG4191	Histidine kinase
J5285_18480	COG1301	dicarboxylic acid transport
J5285_18495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5285_18500	COG4770	biotin carboxylase activity
J5285_18505	COG1737	Transcriptional regulator
J5285_18515	COG3962	Belongs to the TPP enzyme family
J5285_18525	COG3718	enzyme involved in inositol metabolism
J5285_18545	COG0673	inositol 2-dehydrogenase activity
J5285_18555	COG4214	carbohydrate transport
J5285_18590	COG2010	Cytochrome c
J5285_18590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5285_18595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5285_18630	COG2226	methyltransferase
J5285_18650	COG0243	molybdopterin cofactor binding
J5285_18655	COG0395	ABC-type sugar transport system, permease component
J5285_18675	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J5285_18685	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J5285_18690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J5285_18695	COG1473	amidohydrolase
J5285_18700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J5285_18710	COG3842	ATPase activity
J5285_18720	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_18735	COG0183	Belongs to the thiolase family
J5285_18740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5285_18745	COG1959	2 iron, 2 sulfur cluster binding
J5285_18765	COG1215	transferase activity, transferring glycosyl groups
J5285_18775	COG2942	2-epimerase
J5285_18780	COG0436	Aminotransferase
J5285_18790	COG1069	ribulokinase activity
J5285_18810	COG0395	ABC-type sugar transport system, permease component
J5285_18815	COG1175	transmembrane transport
J5285_18825	COG2390	Transcriptional regulator
J5285_18830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_18840	COG0747	negative chemotaxis
J5285_18855	COG4608	Belongs to the ABC transporter superfamily
J5285_18860	COG0444	Belongs to the ABC transporter superfamily
J5285_18865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_18870	COG0601	transmembrane transport
J5285_18875	COG0747	negative chemotaxis
J5285_18885	COG0583	DNA-binding transcription factor activity
J5285_18890	COG1960	acyl-CoA dehydrogenase activity
J5285_18905	COG0477	Major facilitator Superfamily
J5285_18935	COG2835	tetraacyldisaccharide 4'-kinase activity
J5285_18940	COG0673	inositol 2-dehydrogenase activity
J5285_18955	COG0784	Response regulator, receiver
J5285_18955	COG4191	Histidine kinase
J5285_18970	COG0583	DNA-binding transcription factor activity
J5285_18985	COG1116	anion transmembrane transporter activity
J5285_18990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_19000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5285_19020	COG0765	amino acid transport
J5285_19030	COG1473	amidohydrolase
J5285_19035	COG2373	Large extracellular alpha-helical protein
J5285_19040	COG4953	penicillin-binding protein 1C
J5285_19045	COG0583	DNA-binding transcription factor activity
J5285_19065	COG0606	chelatase, subunit chli
J5285_19070	COG0784	Response regulator, receiver
J5285_19070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J5285_19120	COG3304	Inner membrane component domain
J5285_19135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5285_19140	COG0189	ligase activity
J5285_19150	COG1414	Transcriptional regulator
J5285_19155	COG1475	DNA binding
J5285_19160	COG1192	Involved in chromosome partitioning
J5285_19170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5285_19195	COG0251	oxidation-reduction process
J5285_19200	COG1309	transcriptional regulator
J5285_19215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J5285_19220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J5285_19225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J5285_19235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J5285_19250	COG0072	phenylalanine-tRNA ligase activity
J5285_19250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5285_19255	COG3181	Tripartite tricarboxylate transporter family receptor
J5285_19260	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_19265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_19270	COG1335	isochorismatase
J5285_19275	COG0251	oxidation-reduction process
J5285_19280	COG2267	carboxylic ester hydrolase activity
J5285_19285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5285_19310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5285_19320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5285_19325	COG1063	alcohol dehydrogenase
J5285_19330	COG1312	Catalyzes the dehydration of D-mannonate
J5285_19335	COG0246	Mannitol dehydrogenase
J5285_19345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J5285_19355	COG0288	reversible hydration of carbon dioxide
J5285_19370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J5285_19375	COG0539	negative regulation of cytoplasmic translation
J5285_19385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J5285_19395	COG4221	oxidoreductase activity
J5285_19400	COG0673	inositol 2-dehydrogenase activity
J5285_19405	COG0243	molybdopterin cofactor binding
J5285_19415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5285_19420	COG1116	anion transmembrane transporter activity
J5285_19425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_19430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_19435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_19440	COG3707	response regulator
J5285_19445	COG2186	Transcriptional regulator
J5285_19450	COG1027	Aspartate ammonia-lyase
J5285_19460	COG0252	asparaginase activity
J5285_19465	COG1253	flavin adenine dinucleotide binding
J5285_19470	COG4993	Dehydrogenase
J5285_19480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_19495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5285_19500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
J5285_19510	COG0583	DNA-binding transcription factor activity
J5285_19515	COG1012	belongs to the aldehyde dehydrogenase family
J5285_19520	COG0583	DNA-binding transcription factor activity
J5285_19535	COG3842	ATPase activity
J5285_19540	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_19550	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5285_19560	COG1522	sequence-specific DNA binding
J5285_19575	COG0784	Response regulator, receiver
J5285_19595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5285_19610	COG0019	diaminopimelate decarboxylase activity
J5285_19630	COG4150	thiosulfate binding
J5285_19640	COG4208	sulfate ABC transporter
J5285_19645	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J5285_19650	COG1196	nuclear chromosome segregation
J5285_19650	COG0739	heme binding
J5285_19650	COG0741	lytic transglycosylase activity
J5285_19685	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
J5285_19725	COG2814	Major facilitator Superfamily
J5285_19775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_19785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5285_19800	COG0667	Aldo Keto reductase
J5285_19830	COG1570	exodeoxyribonuclease VII activity
J5285_19835	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_19840	COG1846	Transcriptional regulator
J5285_19845	COG0697	spore germination
J5285_19850	COG0372	Belongs to the citrate synthase family
J5285_19860	COG2309	aminopeptidase activity
J5285_19870	COG1393	Belongs to the ArsC family
J5285_19890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5285_19890	COG0519	Catalyzes the synthesis of GMP from XMP
J5285_19930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J5285_19930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J5285_19935	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5285_19945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J5285_19965	COG0284	orotidine-5'-phosphate decarboxylase activity
J5285_19975	COG3963	phosphatidate phosphatase activity
J5285_19985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J5285_19990	COG0792	nuclease activity
J5285_19995	COG1653	transport
J5285_20000	COG1175	transmembrane transport
J5285_20005	COG0395	ABC-type sugar transport system, permease component
J5285_20010	COG3842	ATPase activity
J5285_20015	COG1396	sequence-specific DNA binding
J5285_20025	COG2972	Histidine kinase
J5285_20025	COG0840	transmembrane signaling receptor activity
J5285_20035	COG2207	Transcriptional regulator
J5285_20040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
J5285_20055	COG0542	response to heat
J5285_20070	COG2884	Cell division ATP-binding protein ftsE
J5285_20115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J5285_20120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J5285_20130	COG4974	Belongs to the 'phage' integrase family
J5285_20135	COG0825	malonyl-CoA metabolic process
J5285_20160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5285_20170	COG0300	oxidoreductase activity
J5285_20185	COG0705	Rhomboid family
J5285_20190	COG2086	electron transfer activity
J5285_20200	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5285_20205	COG0625	glutathione transferase activity
J5285_20210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J5285_20215	COG0165	Argininosuccinate lyase
J5285_20240	COG0673	inositol 2-dehydrogenase activity
J5285_20245	COG3206	protein involved in exopolysaccharide biosynthesis
J5285_20245	COG0489	protein tyrosine kinase activity
J5285_20280	COG0438	transferase activity, transferring glycosyl groups
J5285_20295	COG1960	acyl-CoA dehydrogenase activity
J5285_20305	COG0022	dehydrogenase e1 component
J5285_20325	COG3842	ATPase activity
J5285_20330	COG0395	ABC-type sugar transport system, permease component
J5285_20335	COG1175	transmembrane transport
J5285_20340	COG1653	transport
J5285_20345	COG0653	protein targeting
J5285_20350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5285_20355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5285_20365	COG0494	nUDIX hydrolase
J5285_20380	COG2226	methyltransferase
J5285_20385	COG1040	competence protein
J5285_20390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5285_20395	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5285_20405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5285_20420	COG0527	aspartate kinase activity
J5285_20430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J5285_20435	COG2890	protein-(glutamine-N5) methyltransferase activity
J5285_20445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5285_20445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
J5285_20460	COG0189	ligase activity
J5285_20475	COG0425	Belongs to the sulfur carrier protein TusA family
J5285_20475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J5285_20505	COG2137	regulation of response to DNA damage stimulus
J5285_20515	COG2211	Major facilitator Superfamily
J5285_20575	COG0850	regulation of cytokinetic process
J5285_20580	COG2894	cell division
J5285_20585	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
J5285_20595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5285_20605	COG1120	ATPase activity
J5285_20610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_20615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_20625	COG4774	siderophore transport
J5285_20635	COG0840	transmembrane signaling receptor activity
J5285_20645	COG0477	Major facilitator Superfamily
J5285_20655	COG0745	RESPONSE REGULATOR receiver
J5285_20660	COG2194	sulfuric ester hydrolase activity
J5285_20675	COG2133	pyrroloquinoline quinone binding
J5285_20685	COG0500	methyltransferase
J5285_20690	COG0564	pseudouridine synthase activity
J5285_20705	COG0784	Response regulator, receiver
J5285_20705	COG4191	Histidine kinase
J5285_20710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5285_20715	COG3206	protein involved in exopolysaccharide biosynthesis
J5285_20715	COG0489	protein tyrosine kinase activity
J5285_20720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5285_20725	COG1215	transferase activity, transferring glycosyl groups
J5285_20730	COG1215	transferase activity, transferring glycosyl groups
J5285_20735	COG1215	transferase activity, transferring glycosyl groups
J5285_20740	COG0438	transferase activity, transferring glycosyl groups
J5285_20745	COG2273	Hydrolase Family 16
J5285_20750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5285_20755	COG2244	polysaccharide biosynthetic process
J5285_20760	COG0463	Glycosyl transferase, family 2
J5285_20765	COG2327	Polysaccharide pyruvyl transferase
J5285_20770	COG1215	transferase activity, transferring glycosyl groups
J5285_20785	COG1609	Transcriptional regulator
J5285_20790	COG1129	ABC transporter
J5285_20795	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_20800	COG1879	ABC-type sugar transport system periplasmic component
J5285_20810	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
J5285_20815	COG0280	phosphate acetyltransferase
J5285_20815	COG0281	malic enzyme
J5285_20825	COG1192	Involved in chromosome partitioning
J5285_20830	COG2201	protein-glutamate methylesterase activity
J5285_20835	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
J5285_20840	COG0835	chemotaxis
J5285_20845	COG0840	transmembrane signaling receptor activity
J5285_20850	COG0840	transmembrane signaling receptor activity
J5285_20860	COG0840	transmembrane signaling receptor activity
J5285_20865	COG0835	chemotaxis
J5285_20870	COG2198	Histidine kinase
J5285_20870	COG0643	Histidine kinase
J5285_20895	COG1175	transmembrane transport
J5285_20900	COG0395	ABC-type sugar transport system, permease component
J5285_20905	COG3842	ATPase activity
J5285_20915	COG0673	inositol 2-dehydrogenase activity
J5285_20925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J5285_20930	COG0720	synthase
J5285_20935	COG0602	queuosine metabolic process
J5285_20950	COG2094	Belongs to the DNA glycosylase MPG family
J5285_20955	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_20965	COG1376	ErfK ybiS ycfS ynhG family protein
J5285_20980	COG2198	Histidine kinase
J5285_20980	COG5002	protein histidine kinase activity
J5285_20980	COG0784	Response regulator, receiver
J5285_21005	COG0673	inositol 2-dehydrogenase activity
J5285_21010	COG1309	transcriptional regulator
J5285_21020	COG1175	transmembrane transport
J5285_21025	COG0395	ABC-type sugar transport system, permease component
J5285_21035	COG0673	inositol 2-dehydrogenase activity
J5285_21040	COG3842	ATPase activity
J5285_21045	COG2226	methyltransferase
J5285_21055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5285_21060	COG1120	ATPase activity
J5285_21065	COG2072	flavoprotein involved in K transport
J5285_21085	COG3842	ATPase activity
J5285_21090	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_21105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
J5285_21115	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_21120	COG4608	Belongs to the ABC transporter superfamily
J5285_21125	COG0444	Belongs to the ABC transporter superfamily
J5285_21130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_21135	COG0601	transmembrane transport
J5285_21140	COG0747	negative chemotaxis
J5285_21145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J5285_21155	COG0673	inositol 2-dehydrogenase activity
J5285_21180	COG2155	Conserved Protein
J5285_21185	COG3046	protein related to deoxyribodipyrimidine photolyase
J5285_21200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J5285_21205	COG1126	abc transporter atp-binding protein
J5285_21210	COG0765	amino acid transport
J5285_21215	COG0765	amino acid transport
J5285_21220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J5285_21230	COG1802	Transcriptional regulator
J5285_21235	COG2080	2 iron, 2 sulfur cluster binding
J5285_21240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J5285_21245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5285_21250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J5285_21280	COG0489	protein tyrosine kinase activity
J5285_21280	COG3206	protein involved in exopolysaccharide biosynthesis
J5285_21295	COG0438	transferase activity, transferring glycosyl groups
J5285_21310	COG0438	transferase activity, transferring glycosyl groups
J5285_21345	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_21350	COG2814	Major facilitator Superfamily
J5285_21355	COG4774	siderophore transport
J5285_21360	COG3712	iron ion homeostasis
J5285_21385	COG2186	Transcriptional regulator
J5285_21395	COG0765	amino acid transport
J5285_21400	COG0765	amino acid transport
J5285_21410	COG1501	Belongs to the glycosyl hydrolase 31 family
J5285_21415	COG0395	ABC-type sugar transport system, permease component
J5285_21425	COG1653	transport
J5285_21430	COG3842	ATPase activity
J5285_21440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_21445	COG4989	oxidoreductase activity
J5285_21465	COG5001	Diguanylate cyclase
J5285_21470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5285_21475	COG2233	PERMEase
J5285_21480	COG2814	Major facilitator Superfamily
J5285_21565	COG3609	addiction module antidote protein, CC2985 family
J5285_21595	COG4191	Histidine kinase
J5285_21595	COG0784	Response regulator, receiver
J5285_21605	COG1840	ABC-type Fe3 transport system, periplasmic component
J5285_21610	COG1840	ABC-type Fe3 transport system, periplasmic component
J5285_21620	COG3842	ATPase activity
J5285_21625	COG0483	inositol monophosphate 1-phosphatase activity
J5285_21635	COG0626	cystathionine gamma-synthase activity
J5285_21640	COG2182	Extracellular solute-binding protein
J5285_21650	COG0395	ABC-type sugar transport system, permease component
J5285_21685	COG0583	DNA-binding transcription factor activity
J5285_21690	COG0667	Aldo Keto reductase
J5285_21695	COG2814	Major facilitator Superfamily
J5285_21710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5285_21715	COG0363	glucosamine-6-phosphate deaminase activity
J5285_21720	COG1312	Catalyzes the dehydration of D-mannonate
J5285_21725	COG4608	Belongs to the ABC transporter superfamily
J5285_21730	COG0444	Belongs to the ABC transporter superfamily
J5285_21735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_21740	COG0601	transmembrane transport
J5285_21745	COG0747	negative chemotaxis
J5285_21760	COG1940	carbohydrate kinase activity
J5285_21770	COG1309	transcriptional regulator
J5285_21775	COG0596	Alpha beta hydrolase
J5285_21780	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_21790	COG1609	Transcriptional regulator
J5285_21805	COG0601	transmembrane transport
J5285_21810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_21820	COG3622	Belongs to the hyi family
J5285_21825	COG2084	Dehydrogenase
J5285_21845	COG0747	negative chemotaxis
J5285_21855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_21860	COG4172	Belongs to the ABC transporter superfamily
J5285_21910	COG1475	DNA binding
J5285_21955	COG1064	alcohol dehydrogenase
J5285_21990	COG1733	regulation of RNA biosynthetic process
J5285_22010	COG5489	Protein of unknown function (DUF736)
J5285_22105	COG0483	inositol monophosphate 1-phosphatase activity
J5285_22110	COG0584	glycerophosphoryl diester phosphodiesterase
J5285_22120	COG1177	transmembrane transport
J5285_22125	COG1175	transmembrane transport
J5285_22130	COG3842	ATPase activity
J5285_22135	COG1940	carbohydrate kinase activity
J5285_22140	COG3012	SEC-C Motif Domain Protein
J5285_22145	COG4372	Transposase
J5285_22150	COG3436	PFAM IS66 Orf2 family protein
J5285_22170	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J5285_22190	COG2801	Transposase and inactivated derivatives
J5285_22210	COG0436	Aminotransferase
J5285_22270	COG3012	SEC-C Motif Domain Protein
J5285_22335	COG3335	DDE superfamily endonuclease
J5285_22395	COG0745	RESPONSE REGULATOR receiver
J5285_22405	COG1192	Involved in chromosome partitioning
J5285_22415	COG3843	relaxase mobilization nuclease domain protein
J5285_22425	COG3505	Type IV secretory pathway VirD4
J5285_22475	COG3436	PFAM IS66 Orf2 family protein
J5285_22480	COG2963	transposase activity
J5285_22500	COG4372	Transposase
J5285_22505	COG3436	PFAM IS66 Orf2 family protein
J5285_22510	COG2963	transposase activity
J5285_22535	COG1231	oxidoreductase activity
J5285_22550	COG2222	sugar isomerase
J5285_22560	COG0006	proline dipeptidase activity
J5285_22610	COG0583	DNA-binding transcription factor activity
J5285_22640	COG1522	sequence-specific DNA binding
J5285_22655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J5285_22665	COG2040	homocysteine
J5285_22685	COG3842	ATPase activity
J5285_22690	COG0006	proline dipeptidase activity
J5285_22695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5285_22710	COG0765	amino acid transport
J5285_22715	COG0765	amino acid transport
J5285_22720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_22730	COG2826	transposase and inactivated derivatives, IS30 family
J5285_22745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_22765	COG1733	regulation of RNA biosynthetic process
J5285_22795	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_22795	COG3321	synthase
J5285_22795	COG0604	alcohol dehydrogenase
J5285_22805	COG1012	belongs to the aldehyde dehydrogenase family
J5285_22845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_22880	COG1733	regulation of RNA biosynthetic process
J5285_23000	COG1609	Transcriptional regulator
J5285_23020	COG3845	ABC transporter
J5285_23025	COG4603	Belongs to the binding-protein-dependent transport system permease family
J5285_23030	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5285_23055	COG2963	transposase activity
J5285_23060	COG3436	PFAM IS66 Orf2 family protein
J5285_23065	COG4372	Transposase
J5285_23080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5285_23085	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
J5285_23095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5285_23105	COG1012	belongs to the aldehyde dehydrogenase family
J5285_23115	COG3284	Transcriptional regulator
J5285_23120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5285_23130	COG2223	nitrite transmembrane transporter activity
J5285_23140	COG1760	l-serine dehydratase
J5285_23155	COG3842	ATPase activity
J5285_23160	COG3833	ABC-type maltose transport systems, permease component
J5285_23180	COG3547	Transposase (IS116 IS110 IS902 family)
J5285_23205	COG0823	Involved in the tonB-independent uptake of proteins
J5285_23220	COG3842	ATPase activity
J5285_23225	COG0395	ABC-type sugar transport system, permease component
J5285_23230	COG1175	transmembrane transport
J5285_23235	COG1653	transport
J5285_23240	COG1609	Transcriptional regulator
J5285_23260	COG3842	ATPase activity
J5285_23265	COG0656	L-ascorbic acid biosynthetic process
J5285_23270	COG0395	ABC-type sugar transport system, permease component
J5285_23285	COG1312	Catalyzes the dehydration of D-mannonate
J5285_23290	COG1414	Transcriptional regulator
J5285_23295	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_23305	COG4702	Belongs to the UPF0303 family
J5285_23315	COG1063	alcohol dehydrogenase
J5285_23320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5285_23325	COG3265	gluconokinase activity
J5285_23330	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_23340	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_23360	COG0436	Aminotransferase
J5285_23375	COG1079	Belongs to the binding-protein-dependent transport system permease family
J5285_23430	COG2301	Belongs to the HpcH HpaI aldolase family
J5285_23435	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
J5285_23440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5285_23445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5285_23460	COG1802	Transcriptional regulator
J5285_23485	COG0559	Belongs to the binding-protein-dependent transport system permease family
J5285_23495	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_23505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5285_23510	COG1846	Transcriptional regulator
J5285_23520	COG2897	thiosulfate sulfurtransferase activity
J5285_23525	COG1116	anion transmembrane transporter activity
J5285_23525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_23530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5285_23580	COG3701	Conjugal transfer protein
J5285_23585	COG3846	protein secretion by the type IV secretion system
J5285_23595	COG5314	conjugation
J5285_23600	COG3451	type IV secretory pathway VirB4
J5285_23615	COG4962	Type ii secretion system protein e
J5285_23625	COG1192	Involved in chromosome partitioning
J5285_23630	COG1475	DNA binding
J5285_23635	COG0640	Transcriptional regulator
J5285_23665	COG1484	DNA-dependent DNA replication
J5285_23670	COG4584	PFAM Integrase catalytic
J5285_23670	COG2390	Transcriptional regulator
J5285_23680	COG0653	protein targeting
J5285_23705	COG3547	Transposase (IS116 IS110 IS902 family)
J5285_23740	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_23850	COG2207	Transcriptional regulator
J5285_23870	COG1278	Cold shock
J5285_23885	COG0511	ligase activity, forming carbon-carbon bonds
J5285_23890	COG0439	Biotin carboxylase
J5285_23905	COG1984	allophanate hydrolase subunit 2
J5285_23910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
J5285_23915	COG0436	Aminotransferase
J5285_23925	COG4221	oxidoreductase activity
J5285_23930	COG0765	amino acid transport
J5285_23935	COG0765	amino acid transport
J5285_23940	COG1126	abc transporter atp-binding protein
J5285_23945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5285_23950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5285_23955	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_23960	COG3265	gluconokinase activity
J5285_23965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J5285_23970	COG1063	alcohol dehydrogenase
J5285_23975	COG0583	DNA-binding transcription factor activity
J5285_23980	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_23985	COG3959	Transketolase, thiamine diphosphate binding domain
J5285_23990	COG3958	Transketolase
J5285_23995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5285_24000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5285_24005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
J5285_24010	COG1129	ABC transporter
J5285_24015	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_24020	COG1879	ABC-type sugar transport system periplasmic component
J5285_24025	COG3618	amidohydrolase
J5285_24035	COG1609	Transcriptional regulator
J5285_24045	COG1129	ABC transporter
J5285_24050	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_24060	COG1082	Xylose isomerase domain protein TIM barrel
J5285_24065	COG0673	inositol 2-dehydrogenase activity
J5285_24080	COG3962	Belongs to the TPP enzyme family
J5285_24090	COG3718	enzyme involved in inositol metabolism
J5285_24105	COG0673	inositol 2-dehydrogenase activity
J5285_24110	COG0673	inositol 2-dehydrogenase activity
J5285_24120	COG0673	inositol 2-dehydrogenase activity
J5285_24125	COG1609	Transcriptional regulator
J5285_24135	COG0840	transmembrane signaling receptor activity
J5285_24155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_24165	COG2814	Major facilitator Superfamily
J5285_24170	COG2801	Transposase and inactivated derivatives
J5285_24205	COG0601	transmembrane transport
J5285_24210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_24220	COG2843	Capsule synthesis protein
J5285_24225	COG0154	amidase activity
J5285_24240	COG5489	Protein of unknown function (DUF736)
J5285_24260	COG3831	ATPase activity
J5285_24265	COG3505	Type IV secretory pathway VirD4
J5285_24280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5285_24285	COG4959	Type IV secretory pathway protease TraF
J5285_24290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5285_24310	COG1476	TRANSCRIPTIONal
J5285_24325	COG2948	multi-organism process
J5285_24335	COG3504	Conjugal transfer protein
J5285_24340	COG3701	Conjugal transfer protein
J5285_24345	COG3846	protein secretion by the type IV secretion system
J5285_24355	COG5314	conjugation
J5285_24360	COG3451	type IV secretory pathway VirB4
J5285_24365	COG5268	conjugation
J5285_24370	COG3838	Conjugal transfer protein Trbc
J5285_24375	COG4962	Type ii secretion system protein e
J5285_24420	COG1902	pentaerythritol trinitrate reductase activity
J5285_24430	COG0583	DNA-binding transcription factor activity
J5285_24445	COG0583	DNA-binding transcription factor activity
J5285_24465	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_24490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
J5285_24520	COG0210	DNA helicase
J5285_24535	COG0483	inositol monophosphate 1-phosphatase activity
J5285_24540	COG0584	glycerophosphoryl diester phosphodiesterase
J5285_24550	COG4149	molybdate abc transporter
J5285_24555	COG3842	ATPase activity
J5285_24580	COG0753	catalase activity
J5285_24595	COG0673	inositol 2-dehydrogenase activity
J5285_24600	COG0438	transferase activity, transferring glycosyl groups
J5285_24610	COG2205	protein histidine kinase activity
J5285_24620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5285_24630	COG2076	Multidrug Resistance protein
J5285_24645	COG2076	Multidrug Resistance protein
J5285_24655	COG4948	Mandelate Racemase Muconate Lactonizing
J5285_24665	COG2186	Transcriptional regulator
J5285_24675	COG0444	Belongs to the ABC transporter superfamily
J5285_24680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_24685	COG0601	transmembrane transport
J5285_24690	COG0747	negative chemotaxis
J5285_24695	COG5001	Diguanylate cyclase
J5285_24695	COG3300	MHYT domain
J5285_24700	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
J5285_24730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5285_24735	COG4172	Belongs to the ABC transporter superfamily
J5285_24740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_24750	COG0431	NADPH-dependent FMN reductase
J5285_24755	COG0306	phosphate transporter
J5285_24760	COG1392	Phosphate transport regulator
J5285_24770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5285_24790	COG0583	DNA-binding transcription factor activity
J5285_24795	COG0667	Aldo Keto reductase
J5285_24800	COG1396	sequence-specific DNA binding
J5285_24815	COG2030	dehydratase
J5285_24825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5285_24830	COG1960	acyl-CoA dehydrogenase activity
J5285_24835	COG0583	DNA-binding transcription factor activity
J5285_24845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5285_24865	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
J5285_24880	COG3842	ATPase activity
J5285_24885	COG0395	ABC-type sugar transport system, permease component
J5285_24890	COG1175	transmembrane transport
J5285_24910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
J5285_24915	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_24920	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
J5285_24940	COG2972	Histidine kinase
J5285_24940	COG0840	transmembrane signaling receptor activity
J5285_24945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5285_24955	COG1802	Transcriptional regulator
J5285_24960	COG1028	Short-chain dehydrogenase reductase Sdr
J5285_24970	COG3842	ATPase activity
J5285_24975	COG1176	ABC-type spermidine putrescine transport system, permease component I
J5285_24980	COG1177	transmembrane transport
J5285_24985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
J5285_24990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J5285_24995	COG2273	Hydrolase Family 16
J5285_25000	COG0438	transferase activity, transferring glycosyl groups
J5285_25005	COG1215	transferase activity, transferring glycosyl groups
J5285_25010	COG1215	transferase activity, transferring glycosyl groups
J5285_25015	COG1215	transferase activity, transferring glycosyl groups
J5285_25025	COG3206	protein involved in exopolysaccharide biosynthesis
J5285_25025	COG0489	protein tyrosine kinase activity
J5285_25055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J5285_25060	COG2755	lipolytic protein G-D-S-L family
J5285_25060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J5285_25070	COG2244	polysaccharide biosynthetic process
J5285_25090	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
J5285_25095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5285_25120	COG0840	transmembrane signaling receptor activity
J5285_25125	COG4178	(ABC) transporter
J5285_25135	COG1295	ribonuclease BN
J5285_25135	COG1959	2 iron, 2 sulfur cluster binding
J5285_25140	COG2200	EAL domain
J5285_25155	COG1082	Xylose isomerase domain protein TIM barrel
J5285_25160	COG0572	uridine kinase
J5285_25170	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_25175	COG1172	Belongs to the binding-protein-dependent transport system permease family
J5285_25180	COG1129	ABC transporter
J5285_25195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5285_25210	COG1192	Involved in chromosome partitioning
J5285_25215	COG1475	DNA binding
J5285_25220	COG0640	Transcriptional regulator
J5285_25225	COG1686	Belongs to the peptidase S11 family
J5285_25240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5285_25245	COG2828	Protein conserved in bacteria
J5285_25250	COG0583	DNA-binding transcription factor activity
J5285_25325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5285_25330	COG4644	lycopene metabolic process
J5285_25365	COG4372	Transposase
J5285_25370	COG3436	PFAM IS66 Orf2 family protein
J5285_25375	COG2963	transposase activity
J5285_25385	COG3209	COG3209 Rhs family protein
J5285_25485	COG4944	Protein of unknown function (DUF1109)
J5285_25500	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
J5285_25505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
J5285_25530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
J5285_25540	COG3436	PFAM IS66 Orf2 family protein
J5285_25545	COG4372	Transposase
J5285_25550	COG3012	SEC-C Motif Domain Protein
J5285_25555	COG0840	transmembrane signaling receptor activity
J5285_25570	COG3177	Filamentation induced by cAMP protein fic
J5285_25605	COG0784	Response regulator, receiver
J5285_25610	COG3920	Histidine kinase
J5285_25620	COG0784	Response regulator, receiver
J5285_25620	COG4191	Histidine kinase
J5285_25635	COG3920	Histidine kinase
J5285_25635	COG2202	Pas domain
J5285_25645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5285_25665	COG0385	Bile acid
J5285_25670	COG3920	Histidine kinase
J5285_25675	COG4191	Histidine kinase
J5285_25675	COG0784	Response regulator, receiver
J5285_25715	COG0587	DNA-directed DNA polymerase activity
J5285_25725	COG3850	Histidine kinase
J5285_25725	COG5002	protein histidine kinase activity
J5285_25730	COG0745	RESPONSE REGULATOR receiver
J5285_25750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
J5285_25825	COG0640	Transcriptional regulator
J5285_25860	COG3702	type iv secretory pathway
J5285_25865	COG3451	type IV secretory pathway VirB4
J5285_25885	COG3736	Type IV secretory pathway, component VirB8
J5285_25890	COG3504	Conjugal transfer protein
J5285_25895	COG2948	multi-organism process
J5285_25900	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
J5285_25920	COG2184	nucleotidyltransferase activity
J5285_25950	COG1475	DNA binding
J5285_25955	COG1192	Involved in chromosome partitioning
J5285_26005	COG4423	Transcription factor
J5285_26010	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase