locus-tag	class	description
G6M88_00005	COG0475	glutathione-regulated potassium exporter activity
G6M88_00005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G6M88_00015	COG3706	GGDEF domain
G6M88_00020	COG0114	fumarate hydratase activity
G6M88_00030	COG2066	Belongs to the glutaminase family
G6M88_00035	COG0037	tRNA processing
G6M88_00040	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_00045	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_00050	COG2814	Major facilitator Superfamily
G6M88_00055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6M88_00065	COG0187	DNA topoisomerase II activity
G6M88_00075	COG0149	triose-phosphate isomerase activity
G6M88_00085	COG0504	CTP synthase activity
G6M88_00090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G6M88_00105	COG0303	'Molybdopterin
G6M88_00110	COG0315	cyclic pyranopterin monophosphate synthase activity
G6M88_00115	COG0134	indole-3-glycerol-phosphate synthase activity
G6M88_00120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G6M88_00135	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G6M88_00150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G6M88_00155	COG0343	queuine tRNA-ribosyltransferase activity
G6M88_00160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G6M88_00165	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G6M88_00195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6M88_00195	COG2169	Transcriptional regulator
G6M88_00200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G6M88_00225	COG0537	adenosine 5'-monophosphoramidase activity
G6M88_00250	COG0052	Belongs to the universal ribosomal protein uS2 family
G6M88_00255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G6M88_00260	COG0528	UMP kinase activity
G6M88_00265	COG0233	cytoplasmic translational termination
G6M88_00270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G6M88_00280	COG0750	zinc metalloprotease
G6M88_00285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6M88_00290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6M88_00295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6M88_00300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6M88_00305	COG3494	Protein of unknown function (DUF1009)
G6M88_00310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6M88_00315	COG2186	Transcriptional regulator
G6M88_00325	COG0765	amino acid transport
G6M88_00330	COG0765	amino acid transport
G6M88_00355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6M88_00365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G6M88_00370	COG0148	phosphopyruvate hydratase activity
G6M88_00385	COG0667	Aldo Keto reductase
G6M88_00400	COG1121	(ABC) transporter
G6M88_00405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6M88_00420	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6M88_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6M88_00435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G6M88_00440	COG0629	single-stranded DNA binding
G6M88_00450	COG0457	Tetratricopeptide repeat
G6M88_00455	COG2095	MarC family integral membrane protein
G6M88_00460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G6M88_00470	COG1686	Belongs to the peptidase S11 family
G6M88_00495	COG1063	alcohol dehydrogenase
G6M88_00530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G6M88_00540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6M88_00545	COG0084	hydrolase, TatD family'
G6M88_00550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G6M88_00550	COG0321	lipoyl(octanoyl) transferase activity
G6M88_00555	COG0038	chloride channel
G6M88_00645	COG4172	Belongs to the ABC transporter superfamily
G6M88_00670	COG0601	transmembrane transport
G6M88_00675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_00680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_00685	COG2801	Transposase and inactivated derivatives
G6M88_00700	COG1671	Belongs to the UPF0178 family
G6M88_00710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G6M88_00730	COG0546	phosphoglycolate phosphatase activity
G6M88_00735	COG0564	pseudouridine synthase activity
G6M88_00740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6M88_00765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6M88_00770	COG0509	glycine decarboxylation via glycine cleavage system
G6M88_00775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6M88_00775	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6M88_00810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G6M88_00810	COG1648	precorrin-2 dehydrogenase activity
G6M88_00820	COG3956	TIGRFAM MazG family protein
G6M88_00830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G6M88_00835	COG1923	regulation of RNA biosynthetic process
G6M88_00840	COG0569	domain protein
G6M88_00845	COG2204	response regulator
G6M88_00850	COG5000	phosphorelay sensor kinase activity
G6M88_00855	COG2204	response regulator
G6M88_00860	COG3852	Histidine kinase
G6M88_00870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G6M88_00870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G6M88_00875	COG1546	Belongs to the CinA family
G6M88_00875	COG1058	Belongs to the CinA family
G6M88_00880	COG2867	negative regulation of translational initiation
G6M88_00895	COG2207	Transcriptional regulator
G6M88_00900	COG0697	spore germination
G6M88_00905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G6M88_00920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6M88_00930	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6M88_00940	COG0022	dehydrogenase e1 component
G6M88_00940	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6M88_00945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G6M88_00955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G6M88_00985	COG2239	Acts as a magnesium transporter
G6M88_00990	COG0243	molybdopterin cofactor binding
G6M88_01000	COG0242	peptide deformylase activity
G6M88_01015	COG0823	Involved in the tonB-independent uptake of proteins
G6M88_01040	COG0544	peptidyl-prolyl cis-trans isomerase activity
G6M88_01070	COG0384	phenazine biosynthesis protein PhzF
G6M88_01075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G6M88_01095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G6M88_01100	COG0860	N-Acetylmuramoyl-L-alanine amidase
G6M88_01105	COG1530	ribonuclease E activity
G6M88_01120	COG3106	COG3106 Predicted ATPase
G6M88_01125	COG3768	UPF0283 membrane protein
G6M88_01135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G6M88_01140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G6M88_01145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G6M88_01155	COG0633	Ferredoxin
G6M88_01175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G6M88_01175	COG3218	ABC-type transport auxiliary lipoprotein component
G6M88_01185	COG1127	ABC transporter
G6M88_01190	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6M88_01195	COG4948	Mandelate Racemase Muconate Lactonizing
G6M88_01205	COG0281	malic enzyme
G6M88_01205	COG0280	phosphate acetyltransferase
G6M88_01215	COG0778	Nitroreductase
G6M88_01225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6M88_01235	COG0745	RESPONSE REGULATOR receiver
G6M88_01240	COG4191	Histidine kinase
G6M88_01240	COG0784	Response regulator, receiver
G6M88_01245	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_01250	COG0436	Aminotransferase
G6M88_01260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G6M88_01265	COG0511	ligase activity, forming carbon-carbon bonds
G6M88_01270	COG0439	Biotin carboxylase
G6M88_01275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G6M88_01300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6M88_01310	COG0456	acetyltransferase
G6M88_01320	COG0436	Aminotransferase
G6M88_01355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6M88_01360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6M88_01365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6M88_01370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6M88_01380	COG3243	poly(R)-hydroxyalkanoic acid synthase
G6M88_01385	COG1489	DNA binding
G6M88_01390	COG0024	Methionine aminopeptidase
G6M88_01395	COG2003	Belongs to the UPF0758 family
G6M88_01410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G6M88_01430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G6M88_01435	COG0546	phosphoglycolate phosphatase activity
G6M88_01440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G6M88_01445	COG0861	Integral membrane protein TerC family
G6M88_01460	COG1280	lysine exporter protein (LysE YggA)
G6M88_01470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G6M88_01475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
G6M88_01485	COG0538	isocitrate dehydrogenase activity
G6M88_01495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G6M88_01500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G6M88_01505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_01510	COG2313	pseudouridylate synthase activity
G6M88_01535	COG5425	PFAM Usg family protein
G6M88_01545	COG1522	sequence-specific DNA binding
G6M88_01550	COG1573	uracil-dna glycosylase
G6M88_01560	COG2202	Pas domain
G6M88_01560	COG2205	protein histidine kinase activity
G6M88_01570	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G6M88_01575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G6M88_01595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G6M88_01600	COG0739	heme binding
G6M88_01605	COG0513	Belongs to the DEAD box helicase family
G6M88_01625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G6M88_01640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G6M88_01645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G6M88_01650	COG0047	phosphoribosylformylglycinamidine synthase activity
G6M88_01665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6M88_01670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G6M88_01695	COG0321	lipoyl(octanoyl) transferase activity
G6M88_01700	COG1064	alcohol dehydrogenase
G6M88_01710	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G6M88_01710	COG3264	Mechanosensitive ion channel
G6M88_01735	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G6M88_01760	COG1862	Preprotein translocase
G6M88_01795	COG3706	GGDEF domain
G6M88_01800	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G6M88_01805	COG0640	Transcriptional regulator
G6M88_01815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G6M88_01885	COG1794	racemase activity, acting on amino acids and derivatives
G6M88_01910	COG0667	Aldo Keto reductase
G6M88_01960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G6M88_01995	COG1132	(ABC) transporter
G6M88_02000	COG0628	permease
G6M88_02045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G6M88_02050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G6M88_02060	COG0302	gtp cyclohydrolase
G6M88_02065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G6M88_02070	COG1752	Esterase of the alpha-beta hydrolase superfamily
G6M88_02075	COG0516	GMP reductase activity
G6M88_02075	COG0517	IMP dehydrogenase activity
G6M88_02105	COG1760	l-serine dehydratase
G6M88_02125	COG0583	DNA-binding transcription factor activity
G6M88_02150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G6M88_02150	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G6M88_02155	COG0347	Belongs to the P(II) protein family
G6M88_02160	COG0174	glutamine synthetase
G6M88_02185	COG0697	spore germination
G6M88_02195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G6M88_02205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G6M88_02225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G6M88_02230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G6M88_02245	COG1079	Belongs to the binding-protein-dependent transport system permease family
G6M88_02250	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_02255	COG3845	ABC transporter
G6M88_02260	COG1183	phosphatidylcholine synthase activity
G6M88_02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6M88_02270	COG0679	Auxin Efflux Carrier
G6M88_02275	COG0785	Cytochrome C biogenesis protein
G6M88_02295	COG0346	lactoylglutathione lyase activity
G6M88_02300	COG1278	Cold shock
G6M88_02345	COG0577	efflux transmembrane transporter activity
G6M88_02345	COG1136	(ABC) transporter
G6M88_02350	COG0577	efflux transmembrane transporter activity
G6M88_02350	COG1136	(ABC) transporter
G6M88_02355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6M88_02365	COG0316	Belongs to the HesB IscA family
G6M88_02370	COG2151	metal-sulfur cluster biosynthetic enzyme
G6M88_02375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G6M88_02380	COG0719	Fe-S assembly protein
G6M88_02385	COG0396	ATPase activity
G6M88_02390	COG0719	Fe-S assembly protein
G6M88_02395	COG1104	cysteine desulfurase activity
G6M88_02400	COG2945	thiolester hydrolase activity
G6M88_02415	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G6M88_02420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G6M88_02425	COG0842	Transport permease protein
G6M88_02430	COG1131	(ABC) transporter
G6M88_02455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G6M88_02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6M88_02485	COG0129	dihydroxy-acid dehydratase activity
G6M88_02490	COG0583	DNA-binding transcription factor activity
G6M88_02495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G6M88_02505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6M88_02510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G6M88_02530	COG0776	regulation of translation
G6M88_02535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6M88_02540	COG0416	fatty acid biosynthetic process
G6M88_02560	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G6M88_02565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6M88_02570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G6M88_02585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6M88_02585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6M88_02590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G6M88_02595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G6M88_02615	COG0113	porphobilinogen synthase activity
G6M88_02625	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G6M88_02635	COG0484	heat shock protein binding
G6M88_02660	COG3842	ATPase activity
G6M88_02665	COG4149	molybdate abc transporter
G6M88_02675	COG0384	phenazine biosynthesis protein PhzF
G6M88_02680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6M88_02690	COG4115	mRNA cleavage
G6M88_02700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G6M88_02710	COG1733	regulation of RNA biosynthetic process
G6M88_02720	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6M88_02725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G6M88_02735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_02740	COG0840	transmembrane signaling receptor activity
G6M88_02745	COG0656	L-ascorbic acid biosynthetic process
G6M88_02755	COG0440	acetolactate synthase activity
G6M88_02760	COG0028	Belongs to the TPP enzyme family
G6M88_02770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G6M88_02775	COG0560	Phosphoserine phosphatase
G6M88_02805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G6M88_02815	COG0330	HflC and HflK could
G6M88_02820	COG0330	HflC and HflK could
G6M88_02845	COG0277	FAD linked oxidase domain protein
G6M88_02850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6M88_02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_02890	COG1335	isochorismatase
G6M88_02915	COG0006	proline dipeptidase activity
G6M88_02920	COG2264	protein methyltransferase activity
G6M88_02925	COG1999	signal sequence binding
G6M88_02935	COG0835	chemotaxis
G6M88_02945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6M88_02960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G6M88_02965	COG1280	lysine exporter protein (LysE YggA)
G6M88_02970	COG0497	DNA recombination
G6M88_02975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6M88_02985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G6M88_02990	COG0849	cell division
G6M88_02995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G6M88_03000	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6M88_03005	COG0477	Major facilitator Superfamily
G6M88_03010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G6M88_03015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6M88_03020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G6M88_03030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G6M88_03035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6M88_03045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6M88_03060	COG0275	rRNA processing
G6M88_03065	COG2001	Belongs to the MraZ family
G6M88_03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_03090	COG3023	N-Acetylmuramoyl-L-alanine amidase
G6M88_03160	COG0840	transmembrane signaling receptor activity
G6M88_03190	COG2267	carboxylic ester hydrolase activity
G6M88_03195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6M88_03210	COG0251	oxidation-reduction process
G6M88_03225	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_03230	COG2814	Major facilitator Superfamily
G6M88_03235	COG1309	transcriptional regulator
G6M88_03260	COG0531	amino acid
G6M88_03270	COG1737	Transcriptional regulator
G6M88_03280	COG1178	ABC-type Fe3 transport system permease component
G6M88_03290	COG3842	ATPase activity
G6M88_03345	COG2968	Membrane
G6M88_03370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6M88_03375	COG0358	DNA primase activity
G6M88_03395	COG0505	Belongs to the CarA family
G6M88_03415	COG0534	Mate efflux family protein
G6M88_03430	COG2321	neutral zinc metallopeptidase
G6M88_03435	COG0625	glutathione transferase activity
G6M88_03440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6M88_03450	COG1573	uracil-dna glycosylase
G6M88_03460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6M88_03465	COG0438	transferase activity, transferring glycosyl groups
G6M88_03470	COG0438	transferase activity, transferring glycosyl groups
G6M88_03475	COG0463	Glycosyl transferase, family 2
G6M88_03485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6M88_03520	COG1522	sequence-specific DNA binding
G6M88_03525	COG0492	ferredoxin-NADP+ reductase activity
G6M88_03530	COG0583	DNA-binding transcription factor activity
G6M88_03540	COG1902	pentaerythritol trinitrate reductase activity
G6M88_03555	COG0387	Pfam Sodium calcium exchanger
G6M88_03565	COG2200	EAL domain
G6M88_03580	COG1278	Cold shock
G6M88_03585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6M88_03595	COG1846	Transcriptional regulator
G6M88_03600	COG0745	RESPONSE REGULATOR receiver
G6M88_03605	COG2205	protein histidine kinase activity
G6M88_03610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6M88_03630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G6M88_03640	COG1496	oxidoreductase activity
G6M88_03655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G6M88_03660	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_03670	COG3300	MHYT domain
G6M88_03670	COG5001	Diguanylate cyclase
G6M88_03675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G6M88_03690	COG0193	aminoacyl-tRNA hydrolase activity
G6M88_03695	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G6M88_03725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6M88_03730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G6M88_03730	COG2857	Cytochrome c1
G6M88_03750	COG1132	(ABC) transporter
G6M88_03755	COG1132	(ABC) transporter
G6M88_03765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G6M88_03780	COG0408	coproporphyrinogen oxidase activity
G6M88_03790	COG0617	tRNA 3'-terminal CCA addition
G6M88_03805	COG0714	Associated with various cellular activities
G6M88_03825	COG0454	-acetyltransferase
G6M88_03845	COG0435	Glutathione S-transferase
G6M88_03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6M88_03885	COG3135	benzoate transporter
G6M88_03895	COG1733	regulation of RNA biosynthetic process
G6M88_03905	COG0740	serine-type endopeptidase activity
G6M88_03920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6M88_03925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G6M88_03940	COG0512	Glutamine amidotransferase of anthranilate synthase
G6M88_03940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G6M88_03950	COG4771	TonB-dependent receptor
G6M88_03950	COG1629	transport
G6M88_03955	COG2197	response regulator
G6M88_03970	COG1435	thymidine kinase activity
G6M88_03985	COG4175	Glycine betaine
G6M88_04005	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G6M88_04015	COG0366	Alpha amylase catalytic
G6M88_04020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_04045	COG0494	nUDIX hydrolase
G6M88_04050	COG1160	GTP binding
G6M88_04070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G6M88_04075	COG0024	Methionine aminopeptidase
G6M88_04090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G6M88_04095	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_04115	COG0583	DNA-binding transcription factor activity
G6M88_04125	COG0402	S-adenosylhomocysteine deaminase activity
G6M88_04130	COG0840	transmembrane signaling receptor activity
G6M88_04140	COG1304	FMN binding
G6M88_04150	COG1309	transcriptional regulator
G6M88_04155	COG1686	Belongs to the peptidase S11 family
G6M88_04165	COG2351	hydroxyisourate hydrolase activity
G6M88_04170	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
G6M88_04185	COG3648	Uricase
G6M88_04185	COG3195	allantoin biosynthetic process
G6M88_04195	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G6M88_04200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G6M88_04200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_04205	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G6M88_04205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_04210	COG0513	Belongs to the DEAD box helicase family
G6M88_04215	COG5002	protein histidine kinase activity
G6M88_04215	COG2205	protein histidine kinase activity
G6M88_04215	COG0784	Response regulator, receiver
G6M88_04220	COG2259	Doxx family
G6M88_04235	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_04240	COG2308	Evidence 4 Homologs of previously reported genes of
G6M88_04250	COG1305	Transglutaminase-like
G6M88_04265	COG4214	carbohydrate transport
G6M88_04275	COG4213	ABC transporter substrate-binding protein
G6M88_04300	COG4213	ABC transporter substrate-binding protein
G6M88_04305	COG4214	carbohydrate transport
G6M88_04310	COG1129	ABC transporter
G6M88_04330	COG2267	carboxylic ester hydrolase activity
G6M88_04350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6M88_04365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6M88_04370	COG2346	COG2346, Truncated hemoglobins
G6M88_04385	COG1309	transcriptional regulator
G6M88_04410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G6M88_04415	COG0830	nickel cation binding
G6M88_04420	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G6M88_04430	COG0804	urea catabolic process
G6M88_04435	COG3755	Protein conserved in bacteria
G6M88_04440	COG0832	Belongs to the urease beta subunit family
G6M88_04445	COG3813	Protein conserved in bacteria
G6M88_04450	COG0831	urea catabolic process
G6M88_04455	COG0829	nickel cation binding
G6M88_04475	COG0411	ABC transporter
G6M88_04485	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6M88_04500	COG0174	glutamine synthetase
G6M88_04505	COG2205	protein histidine kinase activity
G6M88_04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_04530	COG0683	leucine binding
G6M88_04560	COG1218	3'(2'),5'-bisphosphate nucleotidase
G6M88_04625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6M88_04635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6M88_04645	COG0564	pseudouridine synthase activity
G6M88_04655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6M88_04670	COG0346	lactoylglutathione lyase activity
G6M88_04675	COG2375	cellular response to nickel ion
G6M88_04680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G6M88_04685	COG0346	lactoylglutathione lyase activity
G6M88_04690	COG2832	Protein of unknown function (DUF454)
G6M88_04695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G6M88_04700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_04705	COG4558	Periplasmic binding protein
G6M88_04715	COG3721	Heme iron utilization protein
G6M88_04725	COG3657	addiction module killer protein
G6M88_04730	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_04775	COG0783	Belongs to the Dps family
G6M88_04790	COG2202	Pas domain
G6M88_04790	COG3920	Histidine kinase
G6M88_04800	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G6M88_04810	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G6M88_04830	COG0482	sulfurtransferase activity
G6M88_04845	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_04860	COG5001	Diguanylate cyclase
G6M88_04865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G6M88_04870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6M88_04875	COG0037	tRNA processing
G6M88_04885	COG2885	chlorophyll binding
G6M88_04890	COG0823	Involved in the tonB-independent uptake of proteins
G6M88_04910	COG0824	Thioesterase
G6M88_04915	COG0494	nUDIX hydrolase
G6M88_04930	COG1408	metallophosphoesterase
G6M88_04935	COG2255	four-way junction helicase activity
G6M88_04950	COG0632	four-way junction helicase activity
G6M88_04955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G6M88_04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_04970	COG0217	transcriptional regulatory protein
G6M88_04985	COG1692	metallophosphoesterase
G6M88_04995	COG1253	flavin adenine dinucleotide binding
G6M88_05025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6M88_05030	COG3263	regulation of cellular component size
G6M88_05035	COG0126	phosphoglycerate kinase activity
G6M88_05040	COG3588	fructose-bisphosphate aldolase
G6M88_05065	COG0254	rRNA binding
G6M88_05075	COG1132	(ABC) transporter
G6M88_05100	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_05130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G6M88_05135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G6M88_05140	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G6M88_05145	COG0457	Tetratricopeptide repeat
G6M88_05165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G6M88_05170	COG2951	lytic endotransglycosylase activity
G6M88_05205	COG1487	ribonuclease activity
G6M88_05215	COG0070	glutamate synthase
G6M88_05215	COG0069	glutamate synthase activity
G6M88_05215	COG0067	glutamate synthase
G6M88_05225	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
G6M88_05230	COG1396	sequence-specific DNA binding
G6M88_05245	COG0071	Belongs to the small heat shock protein (HSP20) family
G6M88_05255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6M88_05265	COG3750	Belongs to the UPF0335 family
G6M88_05285	COG0469	pyruvate kinase activity
G6M88_05295	COG3108	Peptidase M15
G6M88_05310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6M88_05320	COG5310	Homospermidine synthase
G6M88_05330	COG0737	Belongs to the 5'-nucleotidase family
G6M88_05335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G6M88_05340	COG0330	HflC and HflK could
G6M88_05365	COG3237	CsbD-like
G6M88_05370	COG2197	response regulator
G6M88_05390	COG1120	ATPase activity
G6M88_05445	COG2307	Protein conserved in bacteria
G6M88_05445	COG2308	Evidence 4 Homologs of previously reported genes of
G6M88_05460	COG0058	SHG alpha-glucan phosphorylase activity
G6M88_05465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6M88_05470	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G6M88_05475	COG0297	glycogen (starch) synthase activity
G6M88_05480	COG0033	Phosphoglucomutase
G6M88_05485	COG1523	belongs to the glycosyl hydrolase 13 family
G6M88_05500	COG0531	amino acid
G6M88_05515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6M88_05515	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6M88_05530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_05535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G6M88_05550	COG1686	Belongs to the peptidase S11 family
G6M88_05565	COG1132	(ABC) transporter
G6M88_05585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6M88_05590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
G6M88_05595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6M88_05600	COG1609	Transcriptional regulator
G6M88_05605	COG1846	Transcriptional regulator
G6M88_05615	COG0523	cobalamin synthesis protein
G6M88_05640	COG0840	transmembrane signaling receptor activity
G6M88_05640	COG2972	Histidine kinase
G6M88_05655	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G6M88_05665	COG0583	DNA-binding transcription factor activity
G6M88_05685	COG0800	Aldolase
G6M88_05700	COG1054	Belongs to the UPF0176 family
G6M88_05715	COG2011	ABC-type metal ion transport system permease component
G6M88_05720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G6M88_05725	COG0778	Nitroreductase
G6M88_05730	COG2115	Belongs to the xylose isomerase family
G6M88_05735	COG1070	Carbohydrate kinase
G6M88_05750	COG1566	PFAM secretion protein HlyD family protein
G6M88_05760	COG1253	flavin adenine dinucleotide binding
G6M88_05765	COG0471	metal ion transport
G6M88_05765	COG3273	potassium ion transport
G6M88_05770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6M88_05775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G6M88_05790	COG0803	Belongs to the bacterial solute-binding protein 9 family
G6M88_05795	COG1121	(ABC) transporter
G6M88_05800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6M88_05805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6M88_05815	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_05820	COG1414	Transcriptional regulator
G6M88_05825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G6M88_05845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6M88_05870	COG1069	ribulokinase activity
G6M88_05890	COG0395	ABC-type sugar transport system, permease component
G6M88_05895	COG1175	transmembrane transport
G6M88_05905	COG2390	Transcriptional regulator
G6M88_05915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_05925	COG0747	negative chemotaxis
G6M88_05935	COG4608	Belongs to the ABC transporter superfamily
G6M88_05940	COG0444	Belongs to the ABC transporter superfamily
G6M88_05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_05950	COG0601	transmembrane transport
G6M88_05955	COG0747	negative chemotaxis
G6M88_05965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G6M88_05970	COG1473	amidohydrolase
G6M88_05975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G6M88_05995	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6M88_06010	COG0583	DNA-binding transcription factor activity
G6M88_06015	COG1960	acyl-CoA dehydrogenase activity
G6M88_06030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G6M88_06035	COG4208	sulfate ABC transporter
G6M88_06045	COG4150	thiosulfate binding
G6M88_06065	COG0019	diaminopimelate decarboxylase activity
G6M88_06080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G6M88_06100	COG0784	Response regulator, receiver
G6M88_06115	COG1522	sequence-specific DNA binding
G6M88_06125	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_06130	COG0583	DNA-binding transcription factor activity
G6M88_06145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G6M88_06150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6M88_06165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_06180	COG4993	Dehydrogenase
G6M88_06185	COG0252	asparaginase activity
G6M88_06195	COG2186	Transcriptional regulator
G6M88_06200	COG3707	response regulator
G6M88_06205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6M88_06210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6M88_06215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_06220	COG1116	anion transmembrane transporter activity
G6M88_06225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G6M88_06235	COG0243	molybdopterin cofactor binding
G6M88_06240	COG0514	ATP-dependent DNA helicase (RecQ)
G6M88_06280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G6M88_06285	COG1309	transcriptional regulator
G6M88_06295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6M88_06305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6M88_06310	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
G6M88_06330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_06335	COG0725	ABC transporter, periplasmic molybdate-binding protein
G6M88_06340	COG4149	molybdate abc transporter
G6M88_06345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G6M88_06360	COG2022	thiamine diphosphate biosynthetic process
G6M88_06375	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G6M88_06380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6M88_06390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G6M88_06405	COG1132	(ABC) transporter
G6M88_06410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6M88_06440	COG0438	transferase activity, transferring glycosyl groups
G6M88_06460	COG0747	negative chemotaxis
G6M88_06470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_06480	COG0438	transferase activity, transferring glycosyl groups
G6M88_06490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6M88_06495	COG0671	phosphoesterase, PA-phosphatase related
G6M88_06500	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G6M88_06505	COG0156	8-amino-7-oxononanoate synthase activity
G6M88_06515	COG0729	surface antigen
G6M88_06530	COG0835	chemotaxis
G6M88_06540	COG2223	nitrite transmembrane transporter activity
G6M88_06545	COG3852	Histidine kinase
G6M88_06550	COG2204	response regulator
G6M88_06555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G6M88_06560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G6M88_06565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G6M88_06570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G6M88_06575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G6M88_06580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G6M88_06595	COG4974	Belongs to the 'phage' integrase family
G6M88_06615	COG1280	lysine exporter protein (LysE YggA)
G6M88_06625	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6M88_06635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G6M88_06640	COG0045	succinate-CoA ligase (ADP-forming) activity
G6M88_06645	COG0039	L-malate dehydrogenase activity
G6M88_06650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G6M88_06685	COG2264	protein methyltransferase activity
G6M88_06700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6M88_06705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G6M88_06710	COG0181	hydroxymethylbilane synthase activity
G6M88_06750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G6M88_06775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G6M88_06780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G6M88_06790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6M88_06795	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G6M88_06800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G6M88_06805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G6M88_06810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G6M88_06815	COG0799	negative regulation of ribosome biogenesis
G6M88_06820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G6M88_06830	COG0793	Belongs to the peptidase S41A family
G6M88_06840	COG0494	nUDIX hydrolase
G6M88_06855	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_06870	COG2270	Major facilitator Superfamily
G6M88_06875	COG2902	Dehydrogenase
G6M88_06880	COG1329	Transcriptional regulator
G6M88_06890	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
G6M88_06910	COG0488	(ABC) transporter
G6M88_06920	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
G6M88_06930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6M88_06935	COG0142	geranyltranstransferase activity
G6M88_06940	COG1349	DNA-binding transcription factor activity
G6M88_06945	COG2223	nitrite transmembrane transporter activity
G6M88_06950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G6M88_06955	COG2885	chlorophyll binding
G6M88_06960	COG1132	(ABC) transporter
G6M88_06965	COG2197	response regulator
G6M88_06970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G6M88_06980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6M88_06990	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_07010	COG1473	amidohydrolase
G6M88_07015	COG3459	Glycosyltransferase 36 associated
G6M88_07020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G6M88_07025	COG0495	leucyl-tRNA aminoacylation
G6M88_07040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G6M88_07055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6M88_07060	COG1946	Acyl-CoA thioesterase
G6M88_07065	COG0347	Belongs to the P(II) protein family
G6M88_07070	COG0004	ammonium transporteR
G6M88_07075	COG1674	ftsk spoiiie
G6M88_07080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G6M88_07100	COG0745	RESPONSE REGULATOR receiver
G6M88_07110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6M88_07125	COG0765	amino acid transport
G6M88_07130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_07135	COG0335	large ribosomal subunit rRNA binding
G6M88_07145	COG0336	Belongs to the RNA methyltransferase TrmD family
G6M88_07150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G6M88_07155	COG0228	four-way junction DNA binding
G6M88_07160	COG0287	Prephenate dehydrogenase
G6M88_07160	COG1605	Chorismate mutase
G6M88_07165	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G6M88_07175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G6M88_07180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6M88_07185	COG0552	protein localization to endoplasmic reticulum
G6M88_07190	COG2917	probably involved in intracellular septation
G6M88_07210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G6M88_07215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G6M88_07220	COG4133	protoheme IX ABC transporter activity
G6M88_07225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G6M88_07240	COG0670	Belongs to the BI1 family
G6M88_07250	COG4181	ATPase activity
G6M88_07260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
G6M88_07265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G6M88_07270	COG2154	pterin-4-alpha-carbinolamine dehydratase
G6M88_07285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G6M88_07295	COG4120	Belongs to the binding-protein-dependent transport system permease family
G6M88_07300	COG1122	ATPase activity
G6M88_07305	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G6M88_07320	COG1280	lysine exporter protein (LysE YggA)
G6M88_07330	COG0137	argininosuccinate synthase activity
G6M88_07335	COG2814	Major facilitator Superfamily
G6M88_07345	COG0339	signal peptide processing
G6M88_07350	COG1217	gtp-binding protein TYPA
G6M88_07360	COG0066	3-isopropylmalate dehydratase activity
G6M88_07365	COG0473	3-isopropylmalate dehydrogenase activity
G6M88_07370	COG1858	cytochrome C peroxidase
G6M88_07380	COG0625	glutathione transferase activity
G6M88_07385	COG1797	cobyrinic acid a,c-diamide synthase activity
G6M88_07390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
G6M88_07455	COG1492	cobalamin metabolic process
G6M88_07470	COG4948	Mandelate Racemase Muconate Lactonizing
G6M88_07475	COG0138	bifunctional purine biosynthesis protein purh
G6M88_07485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6M88_07485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6M88_07490	COG0501	Belongs to the peptidase M48B family
G6M88_07510	COG0357	Ribosomal RNA small subunit methyltransferase G
G6M88_07515	COG0445	tRNA wobble uridine modification
G6M88_07520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G6M88_07525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G6M88_07530	COG1981	membrane
G6M88_07535	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G6M88_07540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G6M88_07545	COG0424	maF-like protein
G6M88_07550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G6M88_07555	COG0237	dephospho-CoA kinase activity
G6M88_07560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6M88_07565	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G6M88_07570	COG3030	protein affecting phage T7 exclusion by the F plasmid
G6M88_07620	COG0135	phosphoribosylanthranilate isomerase activity
G6M88_07625	COG0133	tryptophan synthase activity
G6M88_07630	COG0159	tryptophan synthase activity
G6M88_07635	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G6M88_07660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G6M88_07665	COG3178	'Phosphotransferase
G6M88_07670	COG2205	protein histidine kinase activity
G6M88_07675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G6M88_07680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6M88_07685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G6M88_07685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6M88_07690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G6M88_07695	COG0642	Histidine kinase
G6M88_07700	COG0745	RESPONSE REGULATOR receiver
G6M88_07705	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G6M88_07715	COG1072	(Pantothenic acid kinase))
G6M88_07720	COG0140	phosphoribosyl-ATP diphosphatase activity
G6M88_07725	COG0107	imidazoleglycerol-phosphate synthase activity
G6M88_07730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G6M88_07735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G6M88_07745	COG0131	Imidazoleglycerol-phosphate dehydratase
G6M88_07750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G6M88_07755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G6M88_07765	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G6M88_07780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G6M88_07790	COG1643	Atp-dependent helicase
G6M88_07795	COG2423	ornithine cyclodeaminase activity
G6M88_07835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6M88_07835	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G6M88_07850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6M88_07855	COG1278	Cold shock
G6M88_07860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6M88_07865	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G6M88_07870	COG3474	cytochrome
G6M88_07875	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G6M88_07880	COG0077	Prephenate dehydratase
G6M88_07880	COG1605	Chorismate mutase
G6M88_07885	COG2816	NAD+ diphosphatase activity
G6M88_07900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6M88_07905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G6M88_07915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G6M88_07920	COG2951	lytic endotransglycosylase activity
G6M88_07925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G6M88_07955	COG2900	Belongs to the SlyX family
G6M88_07965	COG0484	heat shock protein binding
G6M88_07970	COG0443	Heat shock 70 kDa protein
G6M88_07975	COG1785	Belongs to the alkaline phosphatase family
G6M88_07985	COG1136	(ABC) transporter
G6M88_07995	COG2814	Major facilitator Superfamily
G6M88_08000	COG0779	Required for maturation of 30S ribosomal subunits
G6M88_08015	COG3064	Membrane
G6M88_08015	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G6M88_08025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G6M88_08030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G6M88_08035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G6M88_08040	COG1185	polyribonucleotide nucleotidyltransferase activity
G6M88_08055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_08080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6M88_08085	COG1072	(Pantothenic acid kinase))
G6M88_08120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6M88_08125	COG1744	ABC transporter substrate-binding protein PnrA-like
G6M88_08130	COG3845	ABC transporter
G6M88_08135	COG1079	Belongs to the binding-protein-dependent transport system permease family
G6M88_08140	COG1079	Belongs to the binding-protein-dependent transport system permease family
G6M88_08145	COG0295	cytidine deaminase activity
G6M88_08150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
G6M88_08155	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G6M88_08160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G6M88_08170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G6M88_08180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6M88_08185	COG2226	methyltransferase
G6M88_08190	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G6M88_08195	COG1024	Enoyl-CoA hydratase
G6M88_08200	COG0268	Binds directly to 16S ribosomal RNA
G6M88_08205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G6M88_08225	COG0640	Transcriptional regulator
G6M88_08235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6M88_08240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G6M88_08245	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G6M88_08250	COG1420	regulation of RNA biosynthetic process
G6M88_08255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6M88_08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6M88_08265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G6M88_08275	COG1137	ATPase activity
G6M88_08280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G6M88_08290	COG0616	signal peptide processing
G6M88_08295	COG0776	regulation of translation
G6M88_08305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G6M88_08310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6M88_08315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G6M88_08330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G6M88_08335	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G6M88_08340	COG0728	peptidoglycan biosynthetic process
G6M88_08345	COG0180	Tryptophanyl-tRNA synthetase
G6M88_08355	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G6M88_08360	COG1214	PFAM Peptidase M22, glycoprotease
G6M88_08365	COG0454	-acetyltransferase
G6M88_08365	COG0456	acetyltransferase
G6M88_08380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6M88_08385	COG1702	phosphate starvation-inducible protein PhoH
G6M88_08390	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G6M88_08395	COG4535	Mg2 and Co2 transporter CorC
G6M88_08400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G6M88_08405	COG1396	sequence-specific DNA binding
G6M88_08410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G6M88_08415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G6M88_08420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_08430	COG0242	peptide deformylase activity
G6M88_08435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G6M88_08440	COG0101	tRNA pseudouridine synthase activity
G6M88_08445	COG1393	Belongs to the ArsC family
G6M88_08460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6M88_08465	COG2171	N-acyltransferase activity
G6M88_08475	COG1957	nucleoside hydrolase
G6M88_08480	COG0071	Belongs to the small heat shock protein (HSP20) family
G6M88_08510	COG0848	biopolymer transport protein
G6M88_08520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G6M88_08525	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G6M88_08530	COG3454	Phosphonate metabolism
G6M88_08535	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G6M88_08540	COG0588	phosphoglycerate mutase activity
G6M88_08545	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G6M88_08550	COG1132	(ABC) transporter
G6M88_08555	COG0837	glucose binding
G6M88_08560	COG1803	Methylglyoxal synthase
G6M88_08565	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
G6M88_08570	COG4166	transmembrane transport
G6M88_08575	COG4174	ABC transporter (Permease)
G6M88_08580	COG4239	(ABC) transporter, permease
G6M88_08585	COG4172	Belongs to the ABC transporter superfamily
G6M88_08590	COG0174	glutamine synthetase
G6M88_08595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_08600	COG3265	gluconokinase activity
G6M88_08605	COG1174	glycine betaine transport
G6M88_08610	COG1125	glycine betaine transport
G6M88_08615	COG1174	glycine betaine transport
G6M88_08620	COG1732	Glycine betaine
G6M88_08630	COG1959	2 iron, 2 sulfur cluster binding
G6M88_08635	COG1840	ABC-type Fe3 transport system, periplasmic component
G6M88_08645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6M88_08655	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G6M88_08660	COG3618	amidohydrolase
G6M88_08665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6M88_08680	COG0477	Major facilitator Superfamily
G6M88_08690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6M88_08695	COG1845	cytochrome c oxidase, subunit III
G6M88_08700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G6M88_08710	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
G6M88_08715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G6M88_08720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G6M88_08740	COG0697	spore germination
G6M88_08755	COG0791	NLP P60 protein
G6M88_08765	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G6M88_08770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G6M88_08805	COG4964	Belongs to the GSP D family
G6M88_08845	COG1396	sequence-specific DNA binding
G6M88_08850	COG0481	GTPase activity
G6M88_08870	COG3757	hydrolase, family 25
G6M88_08875	COG0840	transmembrane signaling receptor activity
G6M88_08875	COG2972	Histidine kinase
G6M88_08885	COG2169	Transcriptional regulator
G6M88_08885	COG1917	Cupin 2, conserved barrel domain protein
G6M88_08890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6M88_08900	COG0251	oxidation-reduction process
G6M88_08905	COG1309	transcriptional regulator
G6M88_08910	COG0488	(ABC) transporter
G6M88_08925	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G6M88_08930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G6M88_08935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G6M88_08945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G6M88_08965	COG0072	phenylalanine-tRNA ligase activity
G6M88_08965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6M88_08980	COG0667	Aldo Keto reductase
G6M88_08990	COG0667	Aldo Keto reductase
G6M88_08995	COG4977	sequence-specific DNA binding
G6M88_09020	COG1570	exodeoxyribonuclease VII activity
G6M88_09025	COG2309	aminopeptidase activity
G6M88_09030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6M88_09035	COG1393	Belongs to the ArsC family
G6M88_09050	COG0519	Catalyzes the synthesis of GMP from XMP
G6M88_09050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6M88_09065	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
G6M88_09095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G6M88_09105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G6M88_09130	COG0284	orotidine-5'-phosphate decarboxylase activity
G6M88_09140	COG3963	phosphatidate phosphatase activity
G6M88_09150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G6M88_09155	COG0792	nuclease activity
G6M88_09170	COG1175	transmembrane transport
G6M88_09175	COG0395	ABC-type sugar transport system, permease component
G6M88_09180	COG3842	ATPase activity
G6M88_09190	COG0189	ligase activity
G6M88_09195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G6M88_09200	COG0756	dUTP diphosphatase activity
G6M88_09210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G6M88_09235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6M88_09245	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G6M88_09250	COG0706	membrane insertase activity
G6M88_09255	COG0594	ribonuclease P activity
G6M88_09260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G6M88_09265	COG0840	transmembrane signaling receptor activity
G6M88_09265	COG2972	Histidine kinase
G6M88_09270	COG3290	protein histidine kinase activity
G6M88_09295	COG3938	Belongs to the proline racemase family
G6M88_09300	COG0418	dihydroorotase activity
G6M88_09305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G6M88_09330	COG1823	symporter activity
G6M88_09345	COG0166	Belongs to the GPI family
G6M88_09355	COG3842	ATPase activity
G6M88_09360	COG1840	ABC-type Fe3 transport system, periplasmic component
G6M88_09365	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G6M88_09385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6M88_09400	COG1595	DNA-templated transcription, initiation
G6M88_09405	COG3806	Anti-sigma factor
G6M88_09420	COG3254	rhamnose metabolic process
G6M88_09430	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_09435	COG1129	ABC transporter
G6M88_09445	COG1349	DNA-binding transcription factor activity
G6M88_09450	COG3347	Dehydrogenase
G6M88_09450	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_09460	COG4952	isomerase
G6M88_09495	COG2326	polyphosphate kinase activity
G6M88_09500	COG5002	protein histidine kinase activity
G6M88_09505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G6M88_09510	COG0573	inorganic phosphate transmembrane transporter activity
G6M88_09520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G6M88_09525	COG0704	Plays a role in the regulation of phosphate uptake
G6M88_09530	COG0745	RESPONSE REGULATOR receiver
G6M88_09535	COG1278	Cold shock
G6M88_09560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6M88_09565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G6M88_09575	COG2967	ApaG domain
G6M88_09585	COG0717	Belongs to the dCTP deaminase family
G6M88_09625	COG0167	dihydroorotate dehydrogenase activity
G6M88_09655	COG1201	RNA secondary structure unwinding
G6M88_09675	COG0730	response to heat
G6M88_09685	COG1960	acyl-CoA dehydrogenase activity
G6M88_09690	COG0183	Belongs to the thiolase family
G6M88_09695	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6M88_09695	COG1024	Enoyl-CoA hydratase
G6M88_09745	COG1157	protein secretion by the type III secretion system
G6M88_09750	COG4786	Flagellar basal body rod
G6M88_09755	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G6M88_09760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6M88_09765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6M88_09770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6M88_09775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G6M88_09785	COG0436	Aminotransferase
G6M88_09790	COG1970	mechanosensitive ion channel activity
G6M88_09795	COG2198	Histidine kinase
G6M88_09795	COG0784	Response regulator, receiver
G6M88_09795	COG2205	protein histidine kinase activity
G6M88_09800	COG0840	transmembrane signaling receptor activity
G6M88_09800	COG2972	Histidine kinase
G6M88_09805	COG1320	monovalent cation:proton antiporter activity
G6M88_09810	COG2212	antiporter activity
G6M88_09815	COG1863	multisubunit Na H antiporter MnhE subunit
G6M88_09820	COG0651	ATP synthesis coupled electron transport
G6M88_09825	COG1006	Multisubunit Na H antiporter MnhC subunit
G6M88_09830	COG2111	Na H antiporter
G6M88_09830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G6M88_09840	COG0840	transmembrane signaling receptor activity
G6M88_09850	COG0745	RESPONSE REGULATOR receiver
G6M88_09855	COG2198	Histidine kinase
G6M88_09855	COG0643	Histidine kinase
G6M88_09860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G6M88_09865	COG2201	protein-glutamate methylesterase activity
G6M88_09870	COG0745	RESPONSE REGULATOR receiver
G6M88_09875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G6M88_09900	COG1766	The M ring may be actively involved in energy transduction
G6M88_09905	COG2771	luxR family
G6M88_09925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6M88_09930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6M88_09935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6M88_09940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6M88_09950	COG1360	Flagellar Motor Protein
G6M88_09975	COG1749	Flagellar hook protein flgE
G6M88_09990	COG5442	Flagellar protein FlaF
G6M88_09995	COG5443	negative regulation of bacterial-type flagellum assembly
G6M88_10000	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G6M88_10005	COG4794	Type iii secretion
G6M88_10020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6M88_10030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G6M88_10035	COG5328	Belongs to the UPF0262 family
G6M88_10045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6M88_10050	COG0424	maF-like protein
G6M88_10055	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G6M88_10065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G6M88_10095	COG1338	Plays a role in the flagellum-specific transport system
G6M88_10105	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G6M88_10115	COG1706	bacterial-type flagellum-dependent cell motility
G6M88_10120	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
G6M88_10125	COG4786	Flagellar basal body rod
G6M88_10130	COG1677	Flagellar hook-basal body complex protein FliE
G6M88_10135	COG1558	bacterial-type flagellum-dependent cell motility
G6M88_10140	COG1815	bacterial-type flagellum-dependent cell motility
G6M88_10150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G6M88_10155	COG1609	Transcriptional regulator
G6M88_10160	COG1653	transport
G6M88_10165	COG1175	transmembrane transport
G6M88_10170	COG0395	ABC-type sugar transport system, permease component
G6M88_10175	COG0366	Alpha amylase catalytic
G6M88_10180	COG3842	ATPase activity
G6M88_10195	COG0129	dihydroxy-acid dehydratase activity
G6M88_10200	COG0363	glucosamine-6-phosphate deaminase activity
G6M88_10205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G6M88_10210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_10220	COG2081	HI0933 family
G6M88_10245	COG2224	Isocitrate lyase
G6M88_10260	COG3842	ATPase activity
G6M88_10265	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6M88_10270	COG1177	transmembrane transport
G6M88_10275	COG1177	transmembrane transport
G6M88_10280	COG2205	protein histidine kinase activity
G6M88_10290	COG0248	Ppx GppA phosphatase
G6M88_10295	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G6M88_10300	COG0477	Major facilitator Superfamily
G6M88_10325	COG0583	DNA-binding transcription factor activity
G6M88_10345	COG0306	phosphate transporter
G6M88_10355	COG0561	phosphatase activity
G6M88_10360	COG0438	transferase activity, transferring glycosyl groups
G6M88_10365	COG0277	FAD linked oxidase domain protein
G6M88_10370	COG0277	FAD linked oxidase domain protein
G6M88_10375	COG0247	lactate metabolic process
G6M88_10380	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_10385	COG2818	Glycosylase
G6M88_10415	COG0124	histidyl-tRNA synthetase
G6M88_10425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G6M88_10430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G6M88_10435	COG2259	Doxx family
G6M88_10445	COG0459	protein refolding
G6M88_10450	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G6M88_10455	COG2059	Chromate
G6M88_10470	COG0196	riboflavin kinase activity
G6M88_10475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G6M88_10485	COG0590	tRNA wobble adenosine to inosine editing
G6M88_10490	COG1187	pseudouridine synthase activity
G6M88_10495	COG0742	ribosomal rna small subunit methyltransferase
G6M88_10500	COG1752	Esterase of the alpha-beta hydrolase superfamily
G6M88_10505	COG0312	modulator of DNA gyrase
G6M88_10510	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_10520	COG1519	Transferase
G6M88_10530	COG1663	tetraacyldisaccharide 4'-kinase activity
G6M88_10540	COG3685	Protein conserved in bacteria
G6M88_10550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G6M88_10555	COG0784	Response regulator, receiver
G6M88_10555	COG2198	Histidine kinase
G6M88_10555	COG5002	protein histidine kinase activity
G6M88_10560	COG5001	Diguanylate cyclase
G6M88_10560	COG3300	MHYT domain
G6M88_10565	COG3386	PFAM SMP-30 Gluconolaconase
G6M88_10570	COG0800	Aldolase
G6M88_10575	COG3734	2-keto-3-deoxy-galactonokinase
G6M88_10580	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_10590	COG2197	response regulator
G6M88_10605	COG0598	Magnesium transport protein CorA
G6M88_10610	COG3158	transport of potassium into the cell
G6M88_10625	COG0356	it plays a direct role in the translocation of protons across the membrane
G6M88_10635	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G6M88_10640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G6M88_10645	COG0840	transmembrane signaling receptor activity
G6M88_10650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G6M88_10655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G6M88_10670	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6M88_10675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G6M88_10685	COG0142	geranyltranstransferase activity
G6M88_10700	COG2827	Endonuclease containing a URI domain
G6M88_10720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G6M88_10725	COG1704	LemA family
G6M88_10735	COG0752	glycyl-tRNA synthetase alpha subunit
G6M88_10740	COG0751	glycine-tRNA ligase activity
G6M88_10745	COG1683	Conserved Protein
G6M88_10750	COG0840	transmembrane signaling receptor activity
G6M88_10760	COG0151	Belongs to the GarS family
G6M88_10765	COG2183	response to ionizing radiation
G6M88_10770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6M88_10775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G6M88_10790	COG0009	L-threonylcarbamoyladenylate synthase
G6M88_10800	COG4638	Rieske (2fe-2S)
G6M88_10825	COG1960	acyl-CoA dehydrogenase activity
G6M88_10840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6M88_10850	COG0840	transmembrane signaling receptor activity
G6M88_10855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G6M88_10860	COG1741	Belongs to the pirin family
G6M88_10865	COG1722	exodeoxyribonuclease VII activity
G6M88_10870	COG0123	including yeast histone deacetylase and acetoin utilization protein
G6M88_10875	COG1268	BioY protein
G6M88_10880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G6M88_10885	COG1122	ATPase activity
G6M88_10890	COG3214	Protein conserved in bacteria
G6M88_10895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G6M88_10895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G6M88_10900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G6M88_10905	COG3300	MHYT domain
G6M88_10905	COG5001	Diguanylate cyclase
G6M88_10915	COG0406	alpha-ribazole phosphatase activity
G6M88_10920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G6M88_10925	COG0484	heat shock protein binding
G6M88_10935	COG0259	pyridoxamine-phosphate oxidase activity
G6M88_10945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6M88_10955	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G6M88_10960	COG0312	modulator of DNA gyrase
G6M88_10975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6M88_10980	COG0109	protoheme IX farnesyltransferase activity
G6M88_10985	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G6M88_11000	COG3346	SURF1 family
G6M88_11005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G6M88_11010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G6M88_11015	COG0328	RNA-DNA hybrid ribonuclease activity
G6M88_11030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G6M88_11035	COG1121	(ABC) transporter
G6M88_11040	COG0678	peroxiredoxin activity
G6M88_11040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G6M88_11050	COG1678	Uncharacterized ACR, COG1678
G6M88_11070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6M88_11075	COG0612	Peptidase, M16
G6M88_11090	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
G6M88_11100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6M88_11110	COG1268	BioY protein
G6M88_11125	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G6M88_11140	COG1194	a g-specific adenine glycosylase
G6M88_11150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6M88_11155	COG1196	nuclear chromosome segregation
G6M88_11170	COG0840	transmembrane signaling receptor activity
G6M88_11175	COG0574	Belongs to the PEP-utilizing enzyme family
G6M88_11175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G6M88_11215	COG0628	permease
G6M88_11230	COG0579	oxidoreductase
G6M88_11245	COG1215	transferase activity, transferring glycosyl groups
G6M88_11260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G6M88_11265	COG2813	Specifically methylates the guanine in position
G6M88_11270	COG2895	sulfate adenylyltransferase (ATP) activity
G6M88_11275	COG0175	sulfate reduction
G6M88_11280	COG0175	sulfate reduction
G6M88_11285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G6M88_11290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G6M88_11295	COG4208	sulfate ABC transporter
G6M88_11300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G6M88_11320	COG2199	diguanylate cyclase activity
G6M88_11320	COG2200	EAL domain
G6M88_11320	COG2203	Gaf domain
G6M88_11330	COG1309	transcriptional regulator
G6M88_11335	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_11340	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G6M88_11375	COG3300	MHYT domain
G6M88_11375	COG5001	Diguanylate cyclase
G6M88_11385	COG0477	Major facilitator Superfamily
G6M88_11395	COG1793	dna ligase
G6M88_11405	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_11410	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_11425	COG1846	Transcriptional regulator
G6M88_11430	COG1764	response to oxidative stress
G6M88_11470	COG4221	oxidoreductase activity
G6M88_11480	COG0433	COG0433 Predicted ATPase
G6M88_11490	COG1733	regulation of RNA biosynthetic process
G6M88_11495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
G6M88_11500	COG0656	L-ascorbic acid biosynthetic process
G6M88_11510	COG4106	trans-aconitate 2-methyltransferase activity
G6M88_11540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6M88_11550	COG3909	cytochrome
G6M88_11555	COG2010	Cytochrome c
G6M88_11585	COG0789	Transcriptional regulator
G6M88_11605	COG0517	IMP dehydrogenase activity
G6M88_11605	COG4175	Glycine betaine
G6M88_11610	COG4176	ABC-type proline glycine betaine transport system permease component
G6M88_11630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_11655	COG2514	catechol 2,3-dioxygenase activity
G6M88_11665	COG1272	protein, Hemolysin III
G6M88_11685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6M88_11690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G6M88_11690	COG2111	Na H antiporter
G6M88_11695	COG2111	Na H antiporter
G6M88_11700	COG1006	Multisubunit Na H antiporter MnhC subunit
G6M88_11705	COG0651	ATP synthesis coupled electron transport
G6M88_11710	COG1863	multisubunit Na H antiporter MnhE subunit
G6M88_11715	COG2212	antiporter activity
G6M88_11720	COG1320	monovalent cation:proton antiporter activity
G6M88_11725	COG4957	zinc ion binding
G6M88_11750	COG2166	iron-sulfur cluster assembly
G6M88_11760	COG2205	protein histidine kinase activity
G6M88_11800	COG1959	2 iron, 2 sulfur cluster binding
G6M88_11805	COG2267	carboxylic ester hydrolase activity
G6M88_11840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G6M88_11845	COG2983	Belongs to the UPF0260 family
G6M88_11860	COG3077	Addiction module antitoxin, RelB DinJ family
G6M88_11910	COG1621	beta-fructofuranosidase activity
G6M88_11920	COG2010	Cytochrome c
G6M88_11925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G6M88_11940	COG2944	sequence-specific DNA binding
G6M88_11975	COG4695	Portal protein
G6M88_12105	COG4235	cytochrome complex assembly
G6M88_12110	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G6M88_12115	COG1138	Cytochrome C-type biogenesis protein
G6M88_12120	COG3088	subunit of a heme lyase
G6M88_12125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6M88_12135	COG2205	protein histidine kinase activity
G6M88_12140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G6M88_12150	COG1408	metallophosphoesterase
G6M88_12155	COG2202	Pas domain
G6M88_12155	COG2205	protein histidine kinase activity
G6M88_12160	COG0308	aminopeptidase N
G6M88_12165	COG0840	transmembrane signaling receptor activity
G6M88_12190	COG0443	Heat shock 70 kDa protein
G6M88_12225	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_12255	COG1733	regulation of RNA biosynthetic process
G6M88_12260	COG1968	undecaprenyl-diphosphatase activity
G6M88_12270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_12285	COG0646	methionine synthase
G6M88_12285	COG1410	methionine synthase
G6M88_12300	COG2239	Acts as a magnesium transporter
G6M88_12305	COG2814	Major facilitator Superfamily
G6M88_12325	COG0463	Glycosyl transferase, family 2
G6M88_12345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6M88_12375	COG4977	sequence-specific DNA binding
G6M88_12375	COG1917	Cupin 2, conserved barrel domain protein
G6M88_12380	COG2382	esterase
G6M88_12415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6M88_12455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6M88_12460	COG0741	lytic transglycosylase activity
G6M88_12465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_12470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G6M88_12485	COG1758	RNA polymerase activity
G6M88_12505	COG0736	holo-[acyl-carrier-protein] synthase activity
G6M88_12510	COG0681	Belongs to the peptidase S26 family
G6M88_12515	COG0571	ribonuclease III activity
G6M88_12520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6M88_12525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6M88_12530	COG0784	Response regulator, receiver
G6M88_12535	COG1381	Involved in DNA repair and RecF pathway recombination
G6M88_12560	COG0346	lactoylglutathione lyase activity
G6M88_12575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_12580	COG0668	transmembrane transport
G6M88_12590	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
G6M88_12595	COG0354	folic acid binding
G6M88_12615	COG1051	belongs to the nudix hydrolase family
G6M88_12630	COG1742	UPF0060 membrane protein
G6M88_12635	COG2135	peptidase activity
G6M88_12640	COG1183	phosphatidylcholine synthase activity
G6M88_12645	COG0688	phosphatidylethanolamine metabolic process
G6M88_12650	COG5265	(ABC) transporter
G6M88_12685	COG2852	Protein conserved in bacteria
G6M88_12690	COG0215	cysteine-tRNA ligase activity
G6M88_12695	COG4221	oxidoreductase activity
G6M88_12700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G6M88_12705	COG1286	toxin biosynthetic process
G6M88_12725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6M88_12735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G6M88_12765	COG0359	binds to the 23S rRNA
G6M88_12775	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G6M88_12780	COG0360	Binds together with S18 to 16S ribosomal RNA
G6M88_12785	COG0667	Aldo Keto reductase
G6M88_12795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G6M88_12805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6M88_12810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6M88_12815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G6M88_12820	COG1561	YicC-like family, N-terminal region
G6M88_12825	COG0194	GDP metabolic process
G6M88_12840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6M88_12845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6M88_12855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G6M88_12870	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G6M88_12900	COG1215	transferase activity, transferring glycosyl groups
G6M88_12905	COG0488	(ABC) transporter
G6M88_12915	COG0105	UTP biosynthetic process
G6M88_12935	COG0314	molybdopterin synthase activity
G6M88_12945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G6M88_12950	COG0322	excinuclease ABC activity
G6M88_12955	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_12965	COG0625	glutathione transferase activity
G6M88_12970	COG3719	Belongs to the RNase T2 family
G6M88_12980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G6M88_12985	COG0243	molybdopterin cofactor binding
G6M88_13000	COG3668	Plasmid stabilization system
G6M88_13005	COG3609	addiction module antidote protein, CC2985 family
G6M88_13010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G6M88_13015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G6M88_13020	COG0628	permease
G6M88_13030	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G6M88_13035	COG0248	Ppx GppA phosphatase
G6M88_13050	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G6M88_13055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G6M88_13065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G6M88_13070	COG0659	secondary active sulfate transmembrane transporter activity
G6M88_13080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G6M88_13095	COG2382	esterase
G6M88_13100	COG0556	nucleotide-excision repair
G6M88_13145	COG1607	acyl-coa hydrolase
G6M88_13150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6M88_13170	COG0861	Integral membrane protein TerC family
G6M88_13175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6M88_13190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G6M88_13200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G6M88_13205	COG0081	regulation of translation
G6M88_13210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G6M88_13215	COG0222	ribosome binding
G6M88_13220	COG0085	RNA polymerase activity
G6M88_13225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G6M88_13250	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G6M88_13255	COG0049	tRNA binding
G6M88_13260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6M88_13265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6M88_13270	COG0051	transcription antitermination factor activity, RNA binding
G6M88_13275	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G6M88_13280	COG0088	Forms part of the polypeptide exit tunnel
G6M88_13285	COG0089	rRNA binding
G6M88_13290	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G6M88_13295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G6M88_13300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G6M88_13305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G6M88_13310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G6M88_13315	COG0255	Belongs to the universal ribosomal protein uL29 family
G6M88_13320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G6M88_13325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G6M88_13330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G6M88_13335	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G6M88_13340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G6M88_13345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G6M88_13350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G6M88_13355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G6M88_13360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G6M88_13365	COG1841	ribosomal large subunit assembly
G6M88_13370	COG0200	Binds to the 23S rRNA
G6M88_13380	COG0563	adenylate kinase activity
G6M88_13385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G6M88_13390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G6M88_13395	COG0202	RNA polymerase activity
G6M88_13400	COG0203	ribosomal protein L17
G6M88_13415	COG3739	integral membrane protein
G6M88_13425	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G6M88_13430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G6M88_13435	COG0737	Belongs to the 5'-nucleotidase family
G6M88_13455	COG2897	thiosulfate sulfurtransferase activity
G6M88_13470	COG0415	Belongs to the DNA photolyase family
G6M88_13510	COG3932	Exopolysaccharide synthesis, ExoD
G6M88_13540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6M88_13600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6M88_13635	COG3436	PFAM IS66 Orf2 family protein
G6M88_13640	COG2433	Pfam Transposase IS66
G6M88_13655	COG3335	DDE superfamily endonuclease
G6M88_13695	COG1612	heme a metabolic process
G6M88_13700	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G6M88_13710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G6M88_13715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G6M88_13725	COG1832	CoA-binding protein
G6M88_13740	COG2124	cytochrome p450
G6M88_13750	COG2199	diguanylate cyclase activity
G6M88_13755	COG0740	serine-type endopeptidase activity
G6M88_13760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G6M88_13765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G6M88_13790	COG4948	Mandelate Racemase Muconate Lactonizing
G6M88_13795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6M88_13820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6M88_13825	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6M88_13830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6M88_13835	COG0649	NAD binding
G6M88_13845	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G6M88_13850	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G6M88_13860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G6M88_13865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6M88_13890	COG1007	ATP synthesis coupled electron transport
G6M88_13905	COG0346	lactoylglutathione lyase activity
G6M88_13915	COG0442	prolyl-tRNA aminoacylation
G6M88_13925	COG1136	(ABC) transporter
G6M88_13945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G6M88_13965	COG0784	Response regulator, receiver
G6M88_13975	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G6M88_14000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G6M88_14010	COG0758	DNA mediated transformation
G6M88_14015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G6M88_14020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G6M88_14025	COG0540	Belongs to the ATCase OTCase family
G6M88_14030	COG1960	acyl-CoA dehydrogenase activity
G6M88_14065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G6M88_14070	COG2824	Alkylphosphonate utilization operon protein PhnA
G6M88_14075	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G6M88_14085	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6M88_14090	COG0154	amidase activity
G6M88_14105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G6M88_14120	COG1045	serine acetyltransferase
G6M88_14125	COG2267	carboxylic ester hydrolase activity
G6M88_14140	COG0626	cystathionine gamma-synthase activity
G6M88_14145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_14150	COG4597	amino acid ABC transporter
G6M88_14155	COG0765	amino acid transport
G6M88_14160	COG1126	abc transporter atp-binding protein
G6M88_14165	COG0589	response to stress
G6M88_14170	COG1546	Belongs to the CinA family
G6M88_14170	COG1058	Belongs to the CinA family
G6M88_14200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6M88_14210	COG0525	valine-tRNA ligase activity
G6M88_14230	COG0316	Belongs to the HesB IscA family
G6M88_14235	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G6M88_14240	COG0018	arginyl-trna synthetase
G6M88_14250	COG1472	Belongs to the glycosyl hydrolase 3 family
G6M88_14255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G6M88_14260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6M88_14265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6M88_14270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6M88_14275	COG0805	protein transport
G6M88_14280	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G6M88_14285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G6M88_14290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6M88_14295	COG0739	heme binding
G6M88_14300	COG1763	Mo-molybdopterin cofactor biosynthetic process
G6M88_14305	COG0746	molybdenum cofactor guanylyltransferase activity
G6M88_14310	COG2814	Major facilitator Superfamily
G6M88_14315	COG0697	spore germination
G6M88_14320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G6M88_14335	COG3550	peptidyl-serine autophosphorylation
G6M88_14340	COG0697	spore germination
G6M88_14385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_14410	COG1396	sequence-specific DNA binding
G6M88_14430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G6M88_14465	COG0840	transmembrane signaling receptor activity
G6M88_14465	COG2972	Histidine kinase
G6M88_14515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6M88_14535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_14540	COG0601	transmembrane transport
G6M88_14545	COG0583	DNA-binding transcription factor activity
G6M88_14550	COG1473	amidohydrolase
G6M88_14560	COG0444	Belongs to the ABC transporter superfamily
G6M88_14570	COG0726	polysaccharide deacetylase
G6M88_14575	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_14580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_14590	COG0747	negative chemotaxis
G6M88_14595	COG0747	negative chemotaxis
G6M88_14615	COG0784	Response regulator, receiver
G6M88_14615	COG4191	Histidine kinase
G6M88_14625	COG0840	transmembrane signaling receptor activity
G6M88_14630	COG0385	Bile acid
G6M88_14635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G6M88_14650	COG1309	transcriptional regulator
G6M88_14655	COG2207	Transcriptional regulator
G6M88_14660	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_14670	COG1335	isochorismatase
G6M88_14675	COG2085	NADP oxidoreductase coenzyme F420-dependent
G6M88_14680	COG2814	Major facilitator Superfamily
G6M88_14685	COG1846	Transcriptional regulator
G6M88_14690	COG0667	Aldo Keto reductase
G6M88_14705	COG5001	Diguanylate cyclase
G6M88_14705	COG3300	MHYT domain
G6M88_14725	COG4191	Histidine kinase
G6M88_14730	COG4566	intracellular signal transduction
G6M88_14745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G6M88_14745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G6M88_14750	COG0450	alkyl hydroperoxide reductase
G6M88_14785	COG0071	Belongs to the small heat shock protein (HSP20) family
G6M88_14790	COG0484	heat shock protein binding
G6M88_14800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6M88_14805	COG0443	Heat shock 70 kDa protein
G6M88_14840	COG2801	Transposase and inactivated derivatives
G6M88_14840	COG3415	Transposase
G6M88_14845	COG1487	ribonuclease activity
G6M88_14850	COG4691	Plasmid stability protein
G6M88_14870	COG0071	Belongs to the small heat shock protein (HSP20) family
G6M88_14880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_14885	COG1126	abc transporter atp-binding protein
G6M88_14910	COG1120	ATPase activity
G6M88_14915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_14925	COG4774	siderophore transport
G6M88_14945	COG0395	ABC-type sugar transport system, permease component
G6M88_14955	COG2182	Extracellular solute-binding protein
G6M88_14960	COG0626	cystathionine gamma-synthase activity
G6M88_15000	COG1126	abc transporter atp-binding protein
G6M88_15010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_15015	COG0765	amino acid transport
G6M88_15020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_15045	COG3920	Histidine kinase
G6M88_15045	COG2202	Pas domain
G6M88_15055	COG0640	Transcriptional regulator
G6M88_15075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G6M88_15080	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G6M88_15120	COG0318	PFAM AMP-dependent synthetase and ligase
G6M88_15125	COG1024	Enoyl-CoA hydratase
G6M88_15130	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_15140	COG2814	Major facilitator Superfamily
G6M88_15145	COG0235	Class ii aldolase
G6M88_15175	COG0601	transmembrane transport
G6M88_15180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G6M88_15210	COG2986	histidine ammonia-lyase
G6M88_15225	COG0175	sulfate reduction
G6M88_15255	COG1091	dTDP-4-dehydrorhamnose reductase activity
G6M88_15260	COG1088	dTDP-glucose 4,6-dehydratase activity
G6M88_15265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G6M88_15270	COG2226	methyltransferase
G6M88_15310	COG4372	Transposase
G6M88_15315	COG3436	PFAM IS66 Orf2 family protein
G6M88_15320	COG2963	transposase activity
G6M88_15375	COG1368	sulfuric ester hydrolase activity
G6M88_15380	COG0300	oxidoreductase activity
G6M88_15385	COG0156	8-amino-7-oxononanoate synthase activity
G6M88_15390	COG3321	synthase
G6M88_15390	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_15390	COG0604	alcohol dehydrogenase
G6M88_15405	COG0438	transferase activity, transferring glycosyl groups
G6M88_15405	COG1216	Glycosyl transferase, family 2
G6M88_15430	COG2197	response regulator
G6M88_15440	COG3395	kinase activity
G6M88_15450	COG1454	alcohol dehydrogenase
G6M88_15455	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6M88_15465	COG0747	negative chemotaxis
G6M88_15470	COG0601	transmembrane transport
G6M88_15475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_15495	COG4172	Belongs to the ABC transporter superfamily
G6M88_15500	COG1473	amidohydrolase
G6M88_15510	COG0601	transmembrane transport
G6M88_15515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15520	COG0523	cobalamin synthesis protein
G6M88_15535	COG2186	Transcriptional regulator
G6M88_15545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6M88_15550	COG0583	DNA-binding transcription factor activity
G6M88_15565	COG1177	transmembrane transport
G6M88_15570	COG3842	ATPase activity
G6M88_15575	COG2072	flavoprotein involved in K transport
G6M88_15600	COG2116	formate transmembrane transporter activity
G6M88_15625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G6M88_15625	COG2010	Cytochrome c
G6M88_15630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6M88_15635	COG1802	Transcriptional regulator
G6M88_15640	COG1879	ABC-type sugar transport system periplasmic component
G6M88_15645	COG1129	ABC transporter
G6M88_15655	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_15660	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G6M88_15665	COG1312	Catalyzes the dehydration of D-mannonate
G6M88_15670	COG1063	alcohol dehydrogenase
G6M88_15695	COG0747	negative chemotaxis
G6M88_15700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15715	COG4608	Belongs to the ABC transporter superfamily
G6M88_15725	COG0747	negative chemotaxis
G6M88_15730	COG0601	transmembrane transport
G6M88_15735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15740	COG4608	Belongs to the ABC transporter superfamily
G6M88_15745	COG0444	Belongs to the ABC transporter superfamily
G6M88_15775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_15780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_15790	COG1309	transcriptional regulator
G6M88_15795	COG0076	glutamate decarboxylase activity
G6M88_15800	COG3403	YqcI/YcgG family
G6M88_15805	COG1446	asparaginase
G6M88_15810	COG0747	negative chemotaxis
G6M88_15825	COG0601	transmembrane transport
G6M88_15830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_15835	COG4172	Belongs to the ABC transporter superfamily
G6M88_15845	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_15855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6M88_15870	COG1129	ABC transporter
G6M88_15875	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_15890	COG1408	metallophosphoesterase
G6M88_15895	COG3842	ATPase activity
G6M88_15900	COG1175	transmembrane transport
G6M88_15915	COG1609	Transcriptional regulator
G6M88_15920	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_15930	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_15940	COG2390	Transcriptional regulator
G6M88_15970	COG1079	Belongs to the binding-protein-dependent transport system permease family
G6M88_15975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6M88_15980	COG1335	isochorismatase
G6M88_15990	COG3845	ABC transporter
G6M88_15995	COG1335	isochorismatase
G6M88_16010	COG1501	Belongs to the glycosyl hydrolase 31 family
G6M88_16015	COG0395	ABC-type sugar transport system, permease component
G6M88_16020	COG1175	transmembrane transport
G6M88_16025	COG1653	transport
G6M88_16030	COG3842	ATPase activity
G6M88_16035	COG2188	Transcriptional regulator
G6M88_16045	COG4989	oxidoreductase activity
G6M88_16055	COG2855	membrane
G6M88_16060	COG0583	DNA-binding transcription factor activity
G6M88_16065	COG1295	ribonuclease BN
G6M88_16075	COG2094	Belongs to the DNA glycosylase MPG family
G6M88_16080	COG3842	ATPase activity
G6M88_16085	COG0673	inositol 2-dehydrogenase activity
G6M88_16095	COG0395	ABC-type sugar transport system, permease component
G6M88_16100	COG1175	transmembrane transport
G6M88_16105	COG1653	transport
G6M88_16110	COG1309	transcriptional regulator
G6M88_16115	COG0673	inositol 2-dehydrogenase activity
G6M88_16135	COG2423	ornithine cyclodeaminase activity
G6M88_16140	COG0010	Belongs to the arginase family
G6M88_16170	COG1116	anion transmembrane transporter activity
G6M88_16170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6M88_16175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_16185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6M88_16200	COG2211	Major facilitator Superfamily
G6M88_16225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G6M88_16235	COG0765	amino acid transport
G6M88_16245	COG2186	Transcriptional regulator
G6M88_16255	COG0154	amidase activity
G6M88_16265	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_16285	COG1609	Transcriptional regulator
G6M88_16290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_16300	COG1335	isochorismatase
G6M88_16315	COG2197	response regulator
G6M88_16335	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G6M88_16340	COG2814	Major facilitator Superfamily
G6M88_16345	COG4774	siderophore transport
G6M88_16350	COG3712	iron ion homeostasis
G6M88_16360	COG3046	protein related to deoxyribodipyrimidine photolyase
G6M88_16365	COG0765	amino acid transport
G6M88_16370	COG0765	amino acid transport
G6M88_16375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_16380	COG1126	abc transporter atp-binding protein
G6M88_16385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G6M88_16395	COG1082	Xylose isomerase domain protein TIM barrel
G6M88_16395	COG3185	4-Hydroxyphenylpyruvate dioxygenase
G6M88_16400	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_16410	COG3842	ATPase activity
G6M88_16425	COG0395	ABC-type sugar transport system, permease component
G6M88_16440	COG1312	Catalyzes the dehydration of D-mannonate
G6M88_16450	COG3842	ATPase activity
G6M88_16455	COG0395	ABC-type sugar transport system, permease component
G6M88_16460	COG1175	transmembrane transport
G6M88_16465	COG1653	transport
G6M88_16470	COG3920	Histidine kinase
G6M88_16470	COG2202	Pas domain
G6M88_16490	COG0243	molybdopterin cofactor binding
G6M88_16495	COG1473	amidohydrolase
G6M88_16505	COG0765	amino acid transport
G6M88_16525	COG0402	S-adenosylhomocysteine deaminase activity
G6M88_16535	COG1162	GTPase activity
G6M88_16540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6M88_16565	COG2144	transferase activity, transferring acyl groups
G6M88_16570	COG0438	transferase activity, transferring glycosyl groups
G6M88_16585	COG0835	chemotaxis
G6M88_16590	COG0840	transmembrane signaling receptor activity
G6M88_16595	COG2197	response regulator
G6M88_16600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_16610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_16615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6M88_16635	COG1802	Transcriptional regulator
G6M88_16645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6M88_16660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6M88_16670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_16675	COG0601	transmembrane transport
G6M88_16680	COG0747	negative chemotaxis
G6M88_16685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_16700	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6M88_16745	COG0741	lytic transglycosylase activity
G6M88_16745	COG0739	heme binding
G6M88_16745	COG1196	nuclear chromosome segregation
G6M88_16750	COG1619	proteins homologs of microcin C7 resistance protein MccF
G6M88_16755	COG0542	response to heat
G6M88_16765	COG2890	protein-(glutamine-N5) methyltransferase activity
G6M88_16770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G6M88_16780	COG0527	aspartate kinase activity
G6M88_16785	COG0513	Belongs to the DEAD box helicase family
G6M88_16795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6M88_16805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6M88_16820	COG2226	methyltransferase
G6M88_16830	COG2186	Transcriptional regulator
G6M88_16845	COG1175	transmembrane transport
G6M88_16850	COG0395	ABC-type sugar transport system, permease component
G6M88_16855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
G6M88_16880	COG0745	RESPONSE REGULATOR receiver
G6M88_16885	COG2205	protein histidine kinase activity
G6M88_16910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6M88_16915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_16920	COG1116	anion transmembrane transporter activity
G6M88_16930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_16955	COG3842	ATPase activity
G6M88_16965	COG1177	transmembrane transport
G6M88_16970	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6M88_16980	COG3842	ATPase activity
G6M88_16985	COG0395	ABC-type sugar transport system, permease component
G6M88_16990	COG1175	transmembrane transport
G6M88_17000	COG1802	Transcriptional regulator
G6M88_17020	COG3842	ATPase activity
G6M88_17025	COG1175	transmembrane transport
G6M88_17030	COG0395	ABC-type sugar transport system, permease component
G6M88_17045	COG3386	PFAM SMP-30 Gluconolaconase
G6M88_17055	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17060	COG1129	ABC transporter
G6M88_17065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6M88_17070	COG1063	alcohol dehydrogenase
G6M88_17075	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_17080	COG2084	Dehydrogenase
G6M88_17090	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_17110	COG3781	membrane
G6M88_17115	COG0583	DNA-binding transcription factor activity
G6M88_17125	COG0765	amino acid transport
G6M88_17130	COG1126	abc transporter atp-binding protein
G6M88_17140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_17150	COG2124	cytochrome p450
G6M88_17210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G6M88_17230	COG1737	Transcriptional regulator
G6M88_17240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_17245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_17250	COG1120	ATPase activity
G6M88_17265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6M88_17275	COG1802	Transcriptional regulator
G6M88_17280	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_17290	COG0306	phosphate transporter
G6M88_17310	COG0395	ABC-type sugar transport system, permease component
G6M88_17325	COG1940	carbohydrate kinase activity
G6M88_17330	COG2354	Protein conserved in bacteria
G6M88_17335	COG1597	lipid kinase activity
G6M88_17340	COG0598	Magnesium transport protein CorA
G6M88_17345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6M88_17355	COG1177	transmembrane transport
G6M88_17365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G6M88_17380	COG0765	amino acid transport
G6M88_17390	COG2186	Transcriptional regulator
G6M88_17395	COG2202	Pas domain
G6M88_17395	COG3920	Histidine kinase
G6M88_17405	COG0784	Response regulator, receiver
G6M88_17415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6M88_17415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6M88_17425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G6M88_17435	COG1349	DNA-binding transcription factor activity
G6M88_17445	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17450	COG1129	ABC transporter
G6M88_17480	COG0149	triose-phosphate isomerase activity
G6M88_17485	COG0698	ribose 5-phosphate isomerase
G6M88_17490	COG1129	ABC transporter
G6M88_17495	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17500	COG1879	ABC-type sugar transport system periplasmic component
G6M88_17505	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_17510	COG2376	Dihydroxyacetone kinase
G6M88_17520	COG2376	Dihydroxyacetone kinase
G6M88_17525	COG1461	Dihydroxyacetone kinase
G6M88_17545	COG0667	Aldo Keto reductase
G6M88_17565	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17570	COG1129	ABC transporter
G6M88_17575	COG4213	ABC transporter substrate-binding protein
G6M88_17580	COG0840	transmembrane signaling receptor activity
G6M88_17585	COG1902	pentaerythritol trinitrate reductase activity
G6M88_17590	COG0640	Transcriptional regulator
G6M88_17600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_17610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G6M88_17620	COG2986	histidine ammonia-lyase
G6M88_17625	COG1228	amidohydrolase
G6M88_17640	COG4221	oxidoreductase activity
G6M88_17650	COG1073	alpha beta
G6M88_17665	COG0753	catalase activity
G6M88_17670	COG4297	protein containing double-stranded beta helix domain
G6M88_17700	COG0784	Response regulator, receiver
G6M88_17730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6M88_17750	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_17760	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
G6M88_17775	COG1079	Belongs to the binding-protein-dependent transport system permease family
G6M88_17780	COG4603	Belongs to the binding-protein-dependent transport system permease family
G6M88_17785	COG3845	ABC transporter
G6M88_17790	COG1744	ABC transporter substrate-binding protein PnrA-like
G6M88_17795	COG2188	Transcriptional regulator
G6M88_17805	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_17815	COG2721	sulfolactate sulfo-lyase activity
G6M88_17835	COG1129	ABC transporter
G6M88_17840	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17845	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17865	COG1129	ABC transporter
G6M88_17875	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_17910	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_17955	COG1070	Carbohydrate kinase
G6M88_18070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6M88_18080	COG0300	oxidoreductase activity
G6M88_18100	COG2086	electron transfer activity
G6M88_18110	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6M88_18115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6M88_18120	COG0165	Argininosuccinate lyase
G6M88_18155	COG2884	Cell division ATP-binding protein ftsE
G6M88_18180	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G6M88_18190	COG0287	Prephenate dehydrogenase
G6M88_18195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6M88_18200	COG2226	methyltransferase
G6M88_18205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6M88_18215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G6M88_18220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G6M88_18225	COG1396	sequence-specific DNA binding
G6M88_18260	COG0438	transferase activity, transferring glycosyl groups
G6M88_18295	COG3206	protein involved in exopolysaccharide biosynthesis
G6M88_18295	COG0489	protein tyrosine kinase activity
G6M88_18325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6M88_18335	COG1192	Involved in chromosome partitioning
G6M88_18340	COG1475	DNA binding
G6M88_18345	COG1414	Transcriptional regulator
G6M88_18365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6M88_18380	COG3052	prosthetic group binding
G6M88_18410	COG4774	siderophore transport
G6M88_18450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_18455	COG4172	Belongs to the ABC transporter superfamily
G6M88_18460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_18465	COG0601	transmembrane transport
G6M88_18470	COG0747	negative chemotaxis
G6M88_18500	COG3842	ATPase activity
G6M88_18505	COG4149	molybdate abc transporter
G6M88_18510	COG1177	transmembrane transport
G6M88_18515	COG0584	glycerophosphoryl diester phosphodiesterase
G6M88_18520	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_18530	COG4702	Belongs to the UPF0303 family
G6M88_18560	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G6M88_18565	COG0539	negative regulation of cytoplasmic translation
G6M88_18585	COG4221	oxidoreductase activity
G6M88_18590	COG0673	inositol 2-dehydrogenase activity
G6M88_18620	COG1653	transport
G6M88_18625	COG1609	Transcriptional regulator
G6M88_18650	COG0747	negative chemotaxis
G6M88_18655	COG0601	transmembrane transport
G6M88_18660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_18670	COG4948	Mandelate Racemase Muconate Lactonizing
G6M88_18685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_18690	COG1802	Transcriptional regulator
G6M88_18745	COG1486	melibiose metabolic process
G6M88_18750	COG0747	negative chemotaxis
G6M88_18755	COG0601	transmembrane transport
G6M88_18760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_18765	COG4172	Belongs to the ABC transporter superfamily
G6M88_18770	COG1486	melibiose metabolic process
G6M88_18800	COG4213	ABC transporter substrate-binding protein
G6M88_18810	COG4214	carbohydrate transport
G6M88_18820	COG1069	ribulokinase activity
G6M88_18825	COG1940	carbohydrate kinase activity
G6M88_18830	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G6M88_18835	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G6M88_18840	COG2188	Transcriptional regulator
G6M88_18850	COG1175	transmembrane transport
G6M88_18855	COG0395	ABC-type sugar transport system, permease component
G6M88_18865	COG3842	ATPase activity
G6M88_18885	COG0251	oxidation-reduction process
G6M88_18890	COG1737	Transcriptional regulator
G6M88_18915	COG3142	Participates in the control of copper homeostasis
G6M88_18925	COG0823	Involved in the tonB-independent uptake of proteins
G6M88_18930	COG1473	amidohydrolase
G6M88_18935	COG0747	negative chemotaxis
G6M88_18940	COG0601	transmembrane transport
G6M88_18945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_18950	COG0444	Belongs to the ABC transporter superfamily
G6M88_18955	COG4608	Belongs to the ABC transporter superfamily
G6M88_18995	COG1091	dTDP-4-dehydrorhamnose reductase activity
G6M88_19025	COG4529	Protein conserved in bacteria
G6M88_19030	COG5002	protein histidine kinase activity
G6M88_19035	COG0745	RESPONSE REGULATOR receiver
G6M88_19055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_19065	COG1309	transcriptional regulator
G6M88_19070	COG1192	Involved in chromosome partitioning
G6M88_19075	COG2201	protein-glutamate methylesterase activity
G6M88_19085	COG0835	chemotaxis
G6M88_19090	COG0840	transmembrane signaling receptor activity
G6M88_19095	COG0840	transmembrane signaling receptor activity
G6M88_19100	COG0835	chemotaxis
G6M88_19105	COG0643	Histidine kinase
G6M88_19105	COG2198	Histidine kinase
G6M88_19125	COG1175	transmembrane transport
G6M88_19130	COG0395	ABC-type sugar transport system, permease component
G6M88_19135	COG3842	ATPase activity
G6M88_19145	COG0673	inositol 2-dehydrogenase activity
G6M88_19165	COG0425	Belongs to the sulfur carrier protein TusA family
G6M88_19165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G6M88_19170	COG0602	queuosine metabolic process
G6M88_19175	COG0720	synthase
G6M88_19180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G6M88_19190	COG1120	ATPase activity
G6M88_19195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_19200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_19210	COG4774	siderophore transport
G6M88_19220	COG2866	Carboxypeptidase
G6M88_19225	COG0747	negative chemotaxis
G6M88_19240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_19255	COG1846	Transcriptional regulator
G6M88_19260	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G6M88_19265	COG1846	Transcriptional regulator
G6M88_19295	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_19305	COG0277	FAD linked oxidase domain protein
G6M88_19310	COG0436	Aminotransferase
G6M88_19320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6M88_19330	COG4608	Belongs to the ABC transporter superfamily
G6M88_19340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_19345	COG0601	transmembrane transport
G6M88_19350	COG0747	negative chemotaxis
G6M88_19360	COG0765	amino acid transport
G6M88_19365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_19385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_19405	COG2814	Major facilitator Superfamily
G6M88_19415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_19440	COG3443	Belongs to the bacterial solute-binding protein 9 family
G6M88_19455	COG0438	transferase activity, transferring glycosyl groups
G6M88_19460	COG0438	transferase activity, transferring glycosyl groups
G6M88_19465	COG1278	Cold shock
G6M88_19470	COG0765	amino acid transport
G6M88_19480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G6M88_19490	COG1802	Transcriptional regulator
G6M88_19500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_19505	COG1335	isochorismatase
G6M88_19510	COG0251	oxidation-reduction process
G6M88_19515	COG2267	carboxylic ester hydrolase activity
G6M88_19520	COG0778	Nitroreductase
G6M88_19525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6M88_19535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G6M88_19545	COG0288	reversible hydration of carbon dioxide
G6M88_19550	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G6M88_19555	COG1802	Transcriptional regulator
G6M88_19560	COG1914	H( )-stimulated, divalent metal cation uptake system
G6M88_19565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G6M88_19570	COG4336	lyase activity
G6M88_19575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G6M88_19580	COG4770	biotin carboxylase activity
G6M88_19585	COG3639	organic phosphonate transmembrane transporter activity
G6M88_19590	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G6M88_19595	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G6M88_19605	COG4778	phosphonate C-P lyase system protein PhnL
G6M88_19610	COG4107	phosphonate C-P lyase system protein PhnK
G6M88_19615	COG3627	carbon phosphorus lyase activity
G6M88_19620	COG3626	phosphonate metabolism
G6M88_19630	COG3624	Phosphonate C-P lyase system protein PhnG
G6M88_19635	COG2188	Transcriptional regulator
G6M88_19650	COG0484	heat shock protein binding
G6M88_19670	COG5001	Diguanylate cyclase
G6M88_19670	COG2203	Gaf domain
G6M88_19670	COG3706	GGDEF domain
G6M88_19670	COG4251	negative regulation of phosphorylation
G6M88_19685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G6M88_19690	COG0406	alpha-ribazole phosphatase activity
G6M88_19715	COG0411	ABC transporter
G6M88_19730	COG0683	leucine binding
G6M88_19735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G6M88_19745	COG0673	inositol 2-dehydrogenase activity
G6M88_19755	COG0523	cobalamin synthesis protein
G6M88_19760	COG1686	Belongs to the peptidase S11 family
G6M88_19765	COG1473	amidohydrolase
G6M88_19785	COG2194	sulfuric ester hydrolase activity
G6M88_19795	COG2133	pyrroloquinoline quinone binding
G6M88_19805	COG0500	methyltransferase
G6M88_19810	COG0564	pseudouridine synthase activity
G6M88_19820	COG2081	HI0933 family
G6M88_19825	COG0784	Response regulator, receiver
G6M88_19825	COG4191	Histidine kinase
G6M88_19830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_19835	COG0489	protein tyrosine kinase activity
G6M88_19835	COG3206	protein involved in exopolysaccharide biosynthesis
G6M88_19840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G6M88_19845	COG1215	transferase activity, transferring glycosyl groups
G6M88_19850	COG1215	transferase activity, transferring glycosyl groups
G6M88_19855	COG1215	transferase activity, transferring glycosyl groups
G6M88_19860	COG0438	transferase activity, transferring glycosyl groups
G6M88_19865	COG2273	Hydrolase Family 16
G6M88_19870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G6M88_19875	COG2244	polysaccharide biosynthetic process
G6M88_19880	COG0463	Glycosyl transferase, family 2
G6M88_19885	COG2327	Polysaccharide pyruvyl transferase
G6M88_19890	COG1215	transferase activity, transferring glycosyl groups
G6M88_19905	COG1609	Transcriptional regulator
G6M88_19910	COG1129	ABC transporter
G6M88_19915	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_19920	COG1879	ABC-type sugar transport system periplasmic component
G6M88_19925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_19930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G6M88_19935	COG0280	phosphate acetyltransferase
G6M88_19935	COG0281	malic enzyme
G6M88_19955	COG2137	regulation of response to DNA damage stimulus
G6M88_20000	COG2942	2-epimerase
G6M88_20005	COG1959	2 iron, 2 sulfur cluster binding
G6M88_20010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6M88_20015	COG1301	dicarboxylic acid transport
G6M88_20020	COG4191	Histidine kinase
G6M88_20025	COG2204	response regulator
G6M88_20035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_20040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6M88_20045	COG1522	sequence-specific DNA binding
G6M88_20050	COG0351	phosphomethylpyrimidine kinase
G6M88_20055	COG0352	thiamine-phosphate diphosphorylase activity
G6M88_20060	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G6M88_20065	COG0673	inositol 2-dehydrogenase activity
G6M88_20105	COG4770	biotin carboxylase activity
G6M88_20110	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G6M88_20115	COG1126	abc transporter atp-binding protein
G6M88_20120	COG0765	amino acid transport
G6M88_20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_20130	COG0850	regulation of cytokinetic process
G6M88_20135	COG2894	cell division
G6M88_20140	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G6M88_20145	COG2223	nitrite transmembrane transporter activity
G6M88_20155	COG0583	DNA-binding transcription factor activity
G6M88_20165	COG3119	arylsulfatase activity
G6M88_20185	COG3300	MHYT domain
G6M88_20185	COG5001	Diguanylate cyclase
G6M88_20195	COG3257	ureidoglycine aminohydrolase activity
G6M88_20200	COG2273	Hydrolase Family 16
G6M88_20200	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
G6M88_20210	COG0372	Belongs to the citrate synthase family
G6M88_20215	COG0372	Belongs to the citrate synthase family
G6M88_20220	COG5001	Diguanylate cyclase
G6M88_20220	COG3300	MHYT domain
G6M88_20230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6M88_20235	COG0183	Belongs to the thiolase family
G6M88_20240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G6M88_20250	COG1414	Transcriptional regulator
G6M88_20265	COG0583	DNA-binding transcription factor activity
G6M88_20275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6M88_20280	COG3485	protocatechuate 3,4-dioxygenase
G6M88_20285	COG3485	protocatechuate 3,4-dioxygenase
G6M88_20290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G6M88_20300	COG0693	protein deglycase activity
G6M88_20305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G6M88_20310	COG1596	polysaccharide export
G6M88_20315	COG3307	-O-antigen
G6M88_20330	COG0587	DNA-directed DNA polymerase activity
G6M88_20335	COG2186	Transcriptional regulator
G6M88_20340	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_20345	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_20350	COG1129	ABC transporter
G6M88_20355	COG1879	ABC-type sugar transport system periplasmic component
G6M88_20365	COG0129	dihydroxy-acid dehydratase activity
G6M88_20370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G6M88_20380	COG3145	DNA-N1-methyladenine dioxygenase activity
G6M88_20395	COG0488	(ABC) transporter
G6M88_20405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_20410	COG3962	Belongs to the TPP enzyme family
G6M88_20420	COG3718	enzyme involved in inositol metabolism
G6M88_20425	COG0450	alkyl hydroperoxide reductase
G6M88_20435	COG5265	(ABC) transporter
G6M88_20440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_20450	COG4176	ABC-type proline glycine betaine transport system permease component
G6M88_20475	COG0395	ABC-type sugar transport system, permease component
G6M88_20485	COG3842	ATPase activity
G6M88_20490	COG3842	ATPase activity
G6M88_20505	COG4166	transmembrane transport
G6M88_20510	COG0601	transmembrane transport
G6M88_20515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_20520	COG4172	Belongs to the ABC transporter superfamily
G6M88_20530	COG3300	MHYT domain
G6M88_20530	COG5001	Diguanylate cyclase
G6M88_20540	COG2815	serine threonine protein kinase
G6M88_20540	COG0515	serine threonine protein kinase
G6M88_20630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6M88_20650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6M88_20655	COG0066	3-isopropylmalate dehydratase activity
G6M88_20675	COG1137	ATPase activity
G6M88_20690	COG0431	NADPH-dependent FMN reductase
G6M88_20690	COG1053	succinate dehydrogenase
G6M88_20690	COG3976	FMN-binding domain protein
G6M88_20710	COG2188	Transcriptional regulator
G6M88_20735	COG0489	protein tyrosine kinase activity
G6M88_20735	COG3206	protein involved in exopolysaccharide biosynthesis
G6M88_20765	COG0438	transferase activity, transferring glycosyl groups
G6M88_20775	COG1595	DNA-templated transcription, initiation
G6M88_20820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G6M88_20850	COG0189	ligase activity
G6M88_20855	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G6M88_20855	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G6M88_20860	COG2207	Transcriptional regulator
G6M88_20885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6M88_20890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6M88_20895	COG0583	DNA-binding transcription factor activity
G6M88_20900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G6M88_20910	COG0439	Biotin carboxylase
G6M88_20920	COG1984	allophanate hydrolase subunit 2
G6M88_20960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G6M88_20960	COG3608	succinylglutamate desuccinylase aspartoacylase
G6M88_20975	COG2080	2 iron, 2 sulfur cluster binding
G6M88_20980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G6M88_20985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6M88_20990	COG2199	diguanylate cyclase activity
G6M88_20990	COG2200	EAL domain
G6M88_20990	COG2203	Gaf domain
G6M88_21005	COG3842	ATPase activity
G6M88_21015	COG1175	transmembrane transport
G6M88_21020	COG0395	ABC-type sugar transport system, permease component
G6M88_21040	COG1129	ABC transporter
G6M88_21045	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_21050	COG1737	Transcriptional regulator
G6M88_21070	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G6M88_21080	COG2354	Protein conserved in bacteria
G6M88_21090	COG1129	ABC transporter
G6M88_21095	COG4214	carbohydrate transport
G6M88_21115	COG2721	sulfolactate sulfo-lyase activity
G6M88_21120	COG1063	alcohol dehydrogenase
G6M88_21125	COG1312	Catalyzes the dehydration of D-mannonate
G6M88_21130	COG0246	Mannitol dehydrogenase
G6M88_21145	COG0019	diaminopimelate decarboxylase activity
G6M88_21150	COG5001	Diguanylate cyclase
G6M88_21150	COG3300	MHYT domain
G6M88_21160	COG2249	NAD(P)H dehydrogenase (quinone) activity
G6M88_21165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G6M88_21170	COG0402	S-adenosylhomocysteine deaminase activity
G6M88_21175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_21180	COG1116	anion transmembrane transporter activity
G6M88_21225	COG1175	transmembrane transport
G6M88_21240	COG0673	inositol 2-dehydrogenase activity
G6M88_21245	COG1609	Transcriptional regulator
G6M88_21250	COG0747	negative chemotaxis
G6M88_21255	COG0601	transmembrane transport
G6M88_21265	COG3964	amidohydrolase
G6M88_21280	COG1921	L-seryl-tRNASec selenium transferase activity
G6M88_21285	COG4172	Belongs to the ABC transporter superfamily
G6M88_21295	COG1376	ErfK ybiS ycfS ynhG family protein
G6M88_21300	COG2204	response regulator
G6M88_21310	COG5002	protein histidine kinase activity
G6M88_21310	COG2198	Histidine kinase
G6M88_21310	COG0784	Response regulator, receiver
G6M88_21315	COG0825	malonyl-CoA metabolic process
G6M88_21320	COG4974	Belongs to the 'phage' integrase family
G6M88_21330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G6M88_21335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G6M88_21365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_21400	COG2835	tetraacyldisaccharide 4'-kinase activity
G6M88_21405	COG2373	Large extracellular alpha-helical protein
G6M88_21410	COG4953	penicillin-binding protein 1C
G6M88_21415	COG1120	ATPase activity
G6M88_21420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6M88_21435	COG2226	methyltransferase
G6M88_21440	COG4608	Belongs to the ABC transporter superfamily
G6M88_21445	COG0444	Belongs to the ABC transporter superfamily
G6M88_21450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_21455	COG0601	transmembrane transport
G6M88_21460	COG0747	negative chemotaxis
G6M88_21465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6M88_21470	COG1063	alcohol dehydrogenase
G6M88_21480	COG0673	inositol 2-dehydrogenase activity
G6M88_21490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G6M88_21500	COG0697	spore germination
G6M88_21505	COG0653	protein targeting
G6M88_21510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6M88_21515	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G6M88_21525	COG0494	nUDIX hydrolase
G6M88_21540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G6M88_21550	COG5001	Diguanylate cyclase
G6M88_21550	COG3300	MHYT domain
G6M88_21565	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
G6M88_21570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_21575	COG0840	transmembrane signaling receptor activity
G6M88_21585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_21590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G6M88_21595	COG2217	Heavy metal translocating P-type atpase
G6M88_21605	COG1522	sequence-specific DNA binding
G6M88_21610	COG4172	Belongs to the ABC transporter superfamily
G6M88_21615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_21620	COG0601	transmembrane transport
G6M88_21650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6M88_21655	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_21665	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_21675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_21680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6M88_21705	COG0395	ABC-type sugar transport system, permease component
G6M88_21710	COG1175	transmembrane transport
G6M88_21730	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6M88_21735	COG0477	Major facilitator Superfamily
G6M88_21745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_21750	COG0657	acetylesterase activity
G6M88_21755	COG0583	DNA-binding transcription factor activity
G6M88_21760	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_21785	COG0765	amino acid transport
G6M88_21795	COG2079	MmgE PrpD family protein
G6M88_21800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_21810	COG2390	Transcriptional regulator
G6M88_21815	COG0747	negative chemotaxis
G6M88_21825	COG4608	Belongs to the ABC transporter superfamily
G6M88_21835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_21840	COG0584	glycerophosphoryl diester phosphodiesterase
G6M88_21850	COG0840	transmembrane signaling receptor activity
G6M88_21855	COG2186	Transcriptional regulator
G6M88_21860	COG0747	negative chemotaxis
G6M88_21870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_21875	COG0405	Gamma-glutamyltransferase
G6M88_21880	COG4172	Belongs to the ABC transporter superfamily
G6M88_21885	COG3706	GGDEF domain
G6M88_21890	COG0328	RNA-DNA hybrid ribonuclease activity
G6M88_21900	COG0586	Pfam SNARE associated Golgi protein
G6M88_21905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6M88_21975	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_21980	COG1733	regulation of RNA biosynthetic process
G6M88_21985	COG3547	Transposase (IS116 IS110 IS902 family)
G6M88_21995	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G6M88_22040	COG3436	PFAM IS66 Orf2 family protein
G6M88_22155	COG1609	Transcriptional regulator
G6M88_22160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_22165	COG2814	Major facilitator Superfamily
G6M88_22170	COG3668	Plasmid stabilization system
G6M88_22175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6M88_22185	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_22190	COG0583	DNA-binding transcription factor activity
G6M88_22200	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_22205	COG1846	Transcriptional regulator
G6M88_22220	COG0583	DNA-binding transcription factor activity
G6M88_22225	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_22240	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_22245	COG2207	Transcriptional regulator
G6M88_22265	COG4221	oxidoreductase activity
G6M88_22300	COG0583	DNA-binding transcription factor activity
G6M88_22310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6M88_22315	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6M88_22335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6M88_22345	COG1304	FMN binding
G6M88_22390	COG4221	oxidoreductase activity
G6M88_22390	COG3321	synthase
G6M88_22390	COG0604	alcohol dehydrogenase
G6M88_22390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6M88_22415	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_22445	COG1396	sequence-specific DNA binding
G6M88_22450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_22505	COG3621	Patatin-like phospholipase
G6M88_22510	COG1396	sequence-specific DNA binding
G6M88_22530	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_22555	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6M88_22605	COG0640	Transcriptional regulator
G6M88_22610	COG1475	DNA binding
G6M88_22615	COG1192	Involved in chromosome partitioning
G6M88_22620	COG3916	Acyl-homoserine-lactone synthase
G6M88_22625	COG4962	Type ii secretion system protein e
G6M88_22630	COG3838	Conjugal transfer protein Trbc
G6M88_22635	COG5268	conjugation
G6M88_22640	COG3451	type IV secretory pathway VirB4
G6M88_22645	COG5314	conjugation
G6M88_22660	COG3701	Conjugal transfer protein
G6M88_22665	COG3504	Conjugal transfer protein
G6M88_22675	COG2948	multi-organism process
G6M88_22680	COG2771	luxR family
G6M88_22695	COG3177	Filamentation induced by cAMP protein fic
G6M88_22705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6M88_22710	COG4959	Type IV secretory pathway protease TraF
G6M88_22715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G6M88_22730	COG3505	Type IV secretory pathway VirD4
G6M88_22740	COG3831	ATPase activity
G6M88_22750	COG1196	nuclear chromosome segregation
G6M88_22775	COG5489	Protein of unknown function (DUF736)
G6M88_22795	COG1475	DNA binding
G6M88_22830	COG0154	amidase activity
G6M88_22840	COG2843	Capsule synthesis protein
G6M88_22850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_22855	COG0601	transmembrane transport
G6M88_22860	COG4166	transmembrane transport
G6M88_22870	COG0776	regulation of translation
G6M88_22900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G6M88_22905	COG2801	Transposase and inactivated derivatives
G6M88_22915	COG1126	abc transporter atp-binding protein
G6M88_22920	COG0765	amino acid transport
G6M88_22940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_22945	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_22970	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_22975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6M88_22985	COG0395	ABC-type sugar transport system, permease component
G6M88_22990	COG1175	transmembrane transport
G6M88_22995	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
G6M88_23000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_23010	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_23015	COG1063	alcohol dehydrogenase
G6M88_23020	COG1609	Transcriptional regulator
G6M88_23025	COG0840	transmembrane signaling receptor activity
G6M88_23035	COG0697	spore germination
G6M88_23095	COG0583	DNA-binding transcription factor activity
G6M88_23105	COG4221	oxidoreductase activity
G6M88_23110	COG0300	oxidoreductase activity
G6M88_23115	COG0583	DNA-binding transcription factor activity
G6M88_23120	COG1408	metallophosphoesterase
G6M88_23125	COG1064	alcohol dehydrogenase
G6M88_23165	COG0154	amidase activity
G6M88_23180	COG4521	taurine ABC transporter
G6M88_23185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6M88_23195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6M88_23195	COG1116	anion transmembrane transporter activity
G6M88_23200	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_23210	COG1733	regulation of RNA biosynthetic process
G6M88_23220	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_23225	COG1129	ABC transporter
G6M88_23240	COG1733	regulation of RNA biosynthetic process
G6M88_23245	COG0604	alcohol dehydrogenase
G6M88_23245	COG3321	synthase
G6M88_23250	COG0583	DNA-binding transcription factor activity
G6M88_23255	COG1902	pentaerythritol trinitrate reductase activity
G6M88_23290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6M88_23300	COG1122	ATPase activity
G6M88_23320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6M88_23325	COG2188	Transcriptional regulator
G6M88_23340	COG5002	protein histidine kinase activity
G6M88_23345	COG0745	RESPONSE REGULATOR receiver
G6M88_23365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6M88_23370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_23380	COG2084	Dehydrogenase
G6M88_23385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6M88_23390	COG3842	ATPase activity
G6M88_23395	COG0573	inorganic phosphate transmembrane transporter activity
G6M88_23415	COG0154	amidase activity
G6M88_23445	COG0601	transmembrane transport
G6M88_23450	COG0444	Belongs to the ABC transporter superfamily
G6M88_23455	COG4608	Belongs to the ABC transporter superfamily
G6M88_23480	COG2084	Dehydrogenase
G6M88_23485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6M88_23490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6M88_23500	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G6M88_23500	COG0778	Nitroreductase
G6M88_23505	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6M88_23510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G6M88_23515	COG1920	GTP binding
G6M88_23520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G6M88_23525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6M88_23530	COG1984	allophanate hydrolase subunit 2
G6M88_23540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G6M88_23550	COG0439	Biotin carboxylase
G6M88_23555	COG0583	DNA-binding transcription factor activity
G6M88_23560	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_23565	COG4214	carbohydrate transport
G6M88_23570	COG1129	ABC transporter
G6M88_23575	COG1879	ABC-type sugar transport system periplasmic component
G6M88_23580	COG1012	belongs to the aldehyde dehydrogenase family
G6M88_23595	COG0582	viral genome integration into host DNA
G6M88_23600	COG4974	Belongs to the 'phage' integrase family
G6M88_23610	COG4372	Transposase
G6M88_23615	COG3436	PFAM IS66 Orf2 family protein
G6M88_23620	COG2963	transposase activity
G6M88_23630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6M88_23635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G6M88_23640	COG2390	Transcriptional regulator
G6M88_23645	COG3684	Belongs to the aldolase LacD family
G6M88_23660	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_23675	COG1175	transmembrane transport
G6M88_23690	COG4372	Transposase
G6M88_23695	COG2972	Histidine kinase
G6M88_23695	COG0840	transmembrane signaling receptor activity
G6M88_23715	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
G6M88_23720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6M88_23725	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_23730	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_23735	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_23740	COG1129	ABC transporter
G6M88_23745	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_23750	COG1879	ABC-type sugar transport system periplasmic component
G6M88_23765	COG4214	carbohydrate transport
G6M88_23810	COG3436	PFAM IS66 Orf2 family protein
G6M88_23815	COG2433	Pfam Transposase IS66
G6M88_23860	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6M88_23865	COG3668	Plasmid stabilization system
G6M88_23870	COG2814	Major facilitator Superfamily
G6M88_23875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6M88_23880	COG1609	Transcriptional regulator
G6M88_23895	COG1120	ATPase activity
G6M88_23905	COG4774	siderophore transport
G6M88_23915	COG2226	methyltransferase
G6M88_23920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6M88_23945	COG1074	ATP-dependent DNA helicase activity
G6M88_24070	COG0640	Transcriptional regulator
G6M88_24075	COG1475	DNA binding
G6M88_24080	COG1192	Involved in chromosome partitioning
G6M88_24090	COG4962	Type ii secretion system protein e
G6M88_24105	COG3451	type IV secretory pathway VirB4
G6M88_24110	COG5314	conjugation
G6M88_24120	COG3846	protein secretion by the type IV secretion system
G6M88_24125	COG3701	Conjugal transfer protein
G6M88_24145	COG0840	transmembrane signaling receptor activity
G6M88_24150	COG0523	cobalamin synthesis protein
G6M88_24155	COG0735	belongs to the Fur family
G6M88_24160	COG0523	cobalamin synthesis protein
G6M88_24165	COG0523	cobalamin synthesis protein
G6M88_24180	COG3177	Filamentation induced by cAMP protein fic
G6M88_24185	COG3546	catalase activity
G6M88_24195	COG3300	MHYT domain
G6M88_24195	COG5001	Diguanylate cyclase
G6M88_24220	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6M88_24225	COG3842	ATPase activity
G6M88_24235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G6M88_24240	COG0028	Belongs to the TPP enzyme family
G6M88_24245	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_24250	COG0745	RESPONSE REGULATOR receiver
G6M88_24260	COG0745	RESPONSE REGULATOR receiver
G6M88_24265	COG0156	8-amino-7-oxononanoate synthase activity
G6M88_24325	COG3831	ATPase activity
G6M88_24340	COG1278	Cold shock
G6M88_24395	COG0667	Aldo Keto reductase
G6M88_24415	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_24480	COG0210	DNA helicase
G6M88_24490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G6M88_24510	COG1028	Short-chain dehydrogenase reductase Sdr
G6M88_24540	COG0589	response to stress
G6M88_24545	COG0659	secondary active sulfate transmembrane transporter activity
G6M88_24565	COG0798	PFAM Bile acid sodium symporter
G6M88_24575	COG0431	NADPH-dependent FMN reductase
G6M88_24595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6M88_24605	COG0745	RESPONSE REGULATOR receiver
G6M88_24610	COG2205	protein histidine kinase activity
G6M88_24625	COG3550	peptidyl-serine autophosphorylation
G6M88_24630	COG3620	sequence-specific DNA binding
G6M88_24635	COG4178	(ABC) transporter
G6M88_24640	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_24645	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6M88_24650	COG1129	ABC transporter
G6M88_24670	COG3609	addiction module antidote protein, CC2985 family
G6M88_24675	COG1192	Involved in chromosome partitioning
G6M88_24680	COG1475	DNA binding
G6M88_24685	COG0640	Transcriptional regulator
G6M88_24690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G6M88_24715	COG2211	Major facilitator Superfamily
G6M88_24760	COG4974	Belongs to the 'phage' integrase family
G6M88_24765	COG1051	belongs to the nudix hydrolase family
G6M88_24810	COG1475	DNA binding
G6M88_24835	COG2824	Alkylphosphonate utilization operon protein PhnA
G6M88_24855	COG1280	lysine exporter protein (LysE YggA)
G6M88_24920	COG5489	Protein of unknown function (DUF736)
G6M88_25010	COG1283	sodium-dependent phosphate transmembrane transporter activity
G6M88_25025	COG0747	negative chemotaxis
G6M88_25045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_25050	COG0584	glycerophosphoryl diester phosphodiesterase
G6M88_25055	COG0483	inositol monophosphate 1-phosphatase activity
G6M88_25120	COG3161	chorismate lyase activity
G6M88_25270	COG3436	PFAM IS66 Orf2 family protein
G6M88_25370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6M88_25400	COG0583	DNA-binding transcription factor activity
G6M88_25405	COG0747	negative chemotaxis
G6M88_25420	COG0252	asparaginase activity
G6M88_25425	COG0583	DNA-binding transcription factor activity
G6M88_25445	COG3842	ATPase activity
G6M88_25470	COG3701	Conjugal transfer protein
G6M88_25475	COG3846	protein secretion by the type IV secretion system
G6M88_25485	COG5314	conjugation
G6M88_25490	COG3451	type IV secretory pathway VirB4
G6M88_25505	COG4962	Type ii secretion system protein e
G6M88_25525	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6M88_25530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6M88_25580	COG2378	regulation of single-species biofilm formation
G6M88_25595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6M88_25630	COG2169	Transcriptional regulator
G6M88_25630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6M88_25635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G6M88_25650	COG0840	transmembrane signaling receptor activity
G6M88_25685	COG1192	Involved in chromosome partitioning
G6M88_25690	COG1475	DNA binding
G6M88_25695	COG0640	Transcriptional regulator
G6M88_25700	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G6M88_25720	COG3831	ATPase activity
G6M88_25775	COG1396	sequence-specific DNA binding
G6M88_25790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G6M88_25795	COG1061	Type III restriction enzyme res subunit
G6M88_25800	COG1002	Type II restriction enzyme, methylase subunits
G6M88_25865	COG0038	chloride channel
G6M88_25870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6M88_25880	COG0039	L-malate dehydrogenase activity
G6M88_25890	COG0583	DNA-binding transcription factor activity
G6M88_25990	COG1196	nuclear chromosome segregation
G6M88_26025	COG1002	Type II restriction enzyme, methylase subunits
G6M88_26030	COG1061	Type III restriction enzyme res subunit
G6M88_26035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G6M88_26055	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs