locus-tag class description GH983_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GH983_00010 ENOG4105CSA Coproporphyrinogen iii oxidase GH983_00015 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GH983_00025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GH983_00030 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GH983_00035 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GH983_00040 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GH983_00045 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea GH983_00050 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH983_00055 ENOG4108IUZ ABC transporter GH983_00060 ENOG4105RF0 OstA family GH983_00070 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GH983_00080 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GH983_00085 ENOG4108RWN rrna methyltransferase GH983_00090 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GH983_00105 ENOG4105C6K Malic enzyme GH983_00110 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GH983_00115 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GH983_00130 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GH983_00135 ENOG4105C31 Tryptophanyl-tRNA synthetase GH983_00145 ENOG41083MR nifu domain-containing protein GH983_00160 ENOG41090R7 Ferric uptake GH983_00170 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GH983_00175 ENOG4105C9A Phoh family GH983_00180 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GH983_00185 ENOG4107RCQ (CBS) domain GH983_00190 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GH983_00195 ENOG4108WRK Transcriptional regulator GH983_00200 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GH983_00205 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GH983_00215 ENOG4108ZNX Heat shock protein GH983_00225 ENOG4105C8Q Methyl-accepting chemotaxis GH983_00230 ENOG4108RVA ribokinase GH983_00240 ENOG4105UT3 Methyl-accepting chemotaxis GH983_00250 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GH983_00255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GH983_00260 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GH983_00270 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GH983_00280 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GH983_00310 ENOG4105CAS nag kinase GH983_00330 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GH983_00340 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GH983_00345 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GH983_00355 ENOG4105BZU Histidine kinase GH983_00380 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GH983_00385 ENOG4107XZC Restriction modification system DNA (Specificity GH983_00395 ENOG4105CVR type I restriction-modification system GH983_00410 ENOG4105CTU Proline racemase GH983_00415 ENOG4105IJJ transcriptional regulator, crp fnr family GH983_00430 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator GH983_00435 ENOG4105CNN ABC, transporter GH983_00440 ENOG4105C2J ABC transporter GH983_00445 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) GH983_00450 ENOG4108VYJ response regulator receiver protein GH983_00460 ENOG4105BZU Histidine kinase GH983_00465 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GH983_00470 ENOG4105EKE dihydroorotase GH983_00480 ENOG4107RIV Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GH983_00495 ENOG4107QP8 phosphohexose isomerase GH983_00500 ENOG4105CEY Amp-dependent synthetase and ligase GH983_00530 ENOG4105CSR polyphosphate kinase 2 GH983_00535 ENOG4105BZU Histidine kinase GH983_00545 ENOG4105C8U phosphate abc transporter GH983_00550 ENOG4105E2Z phosphate ABC transporter (Permease GH983_00555 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GH983_00560 ENOG4108UTW Plays a role in the regulation of phosphate uptake GH983_00565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH983_00575 ENOG4105C8Y Acetylornithine aminotransferase GH983_00580 ENOG4105DBV ornithine carbamoyltransferase GH983_00585 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GH983_00595 ENOG4105NWN ApaG protein GH983_00605 ENOG4105DHP deoxycytidine triphosphate deaminase GH983_00620 ENOG4108YYH Nadph-dependent fmn reductase GH983_00665 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GH983_00670 ENOG4107R73 Mate efflux family protein GH983_00695 ENOG4107QRT dEAD DEAH box helicase GH983_00720 ENOG4105CSU acyl-Coa dehydrogenase GH983_00725 ENOG4105CHU acetyl-coa acetyltransferase GH983_00735 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GH983_00740 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GH983_00755 ENOG4105BZU Histidine kinase GH983_00760 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GH983_00765 ENOG4105CHM Aminotransferase GH983_00775 ENOG4105D0S secretion protein (HlyD GH983_00780 ENOG4105CJ1 ABC, transporter GH983_00785 ENOG4105CMI transporter GH983_00790 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GH983_00815 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GH983_00825 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GH983_00830 ENOG4108ZTZ UPF0262 protein GH983_00840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GH983_00845 ENOG4108Z03 MAF-like protein GH983_00850 ENOG41086Q3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GH983_00875 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_00880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH983_00885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_00890 ENOG4105C3U ABC transporter GH983_00895 ENOG4108JQ7 (ABC) transporter GH983_00900 ENOG4105EW9 transcriptional regulator AsnC family GH983_00905 ENOG4105CGF Aromatic amino acid aminotransferase GH983_00915 ENOG4105E0A ABC, transporter GH983_00920 ENOG4105EHG Permease protein GH983_00930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GH983_00940 ENOG4105CHR reductase GH983_00945 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GH983_00960 ENOG4105KVH Transcriptional regulator GH983_00975 ENOG4105CNN ABC, transporter GH983_00985 ENOG4105C2J ABC transporter GH983_00990 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH983_00995 ENOG4105BZU Histidine kinase GH983_01015 ENOG4107QWB Ornithine cyclodeaminase GH983_01020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_01030 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GH983_01035 ENOG4105GAK amidohydrolase 2 GH983_01040 ENOG4105CXK mandelate racemase muconate lactonizing GH983_01045 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GH983_01050 ENOG4107YCY Transcriptional regulator GH983_01055 ENOG4105E9Z Nad-dependent epimerase dehydratase GH983_01070 ENOG4108JJA ABC, transporter GH983_01075 ENOG4105C42 Type I secretion membrane fusion protein (HlyD GH983_01100 ENOG4105WCJ ec 1.1.1.193 GH983_01125 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GH983_01175 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase GH983_01185 ENOG4108JIK carboxylase GH983_01190 ENOG4105P4J Allophanate hydrolase, subunit 1 GH983_01195 ENOG4105CFM UPF0317 protein GH983_01200 ENOG4105E7W lamb ycsf family protein GH983_01205 ENOG4105C5A transporter GH983_01210 ENOG4105DRR Transcriptional regulator, GntR family GH983_01215 ENOG4105CHR reductase GH983_01245 ENOG4105BZU Histidine kinase GH983_01270 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GH983_01280 ENOG4105FDF Could be involved in DNA repair (By similarity) GH983_01285 ENOG4105DQE DNA ligase GH983_01295 ENOG4105UT3 Methyl-accepting chemotaxis GH983_01305 ENOG4108VYJ response regulator receiver protein GH983_01310 ENOG4105CBS Chea signal transduction histidine kinase GH983_01315 ENOG4108V3W Chemotaxis protein, CheW GH983_01320 ENOG4105BZU Histidine kinase GH983_01325 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GH983_01330 ENOG4108VYJ response regulator receiver protein GH983_01335 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GH983_01345 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GH983_01350 ENOG4105VJY transcriptional regulator GH983_01360 ENOG4105QDQ GH983_01365 ENOG4105D00 flagellar biosynthetic protein flhB GH983_01370 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GH983_01375 ENOG4105DD5 Flagellar motor switch protein GH983_01385 ENOG4107RD7 Flagellar Motor Protein, MotA GH983_01390 ENOG4105KTQ flagellar basal-body rod protein GH983_01395 ENOG4108JIR Flagellum-specific ATP synthase GH983_01405 ENOG4105SFI flagellar basal-body rod protein GH983_01410 ENOG4108ZC9 flagellar basal-body rod protein flgc GH983_01415 ENOG4105X50 flagellar hook-basal body complex protein fliE GH983_01420 ENOG4105CGA flagellar basal-body rod protein FlgG GH983_01425 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA GH983_01430 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GH983_01440 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GH983_01450 ENOG4105CN7 Flagellar biosynthetic protein FliP GH983_01465 ENOG4107W75 Flagellin GH983_01470 ENOG4107W75 Flagellin GH983_01480 ENOG4105ER2 Ompa motb domain protein GH983_01485 ENOG4108S15 chemotaxis, protein GH983_01505 ENOG4105BZE flagellar hook protein, FlgE GH983_01510 ENOG4105E1Q flagellar hook-associated protein GH983_01525 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) GH983_01530 ENOG410822I Flagellar hook capping protein GH983_01540 ENOG4105D7B Flagellar biosynthesis protein flha GH983_01545 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GH983_01575 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GH983_01580 ENOG4105FKQ transcriptional regulator GH983_01585 ENOG4105EPJ extracellular solute-binding protein family 1 GH983_01590 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component GH983_01595 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GH983_01600 ENOG4105CG3 alpha amylase, catalytic region GH983_01605 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_01615 ENOG4105CHR reductase GH983_01630 ENOG4108WQI RNA Polymerase GH983_01640 ENOG4107SDU Methyl-accepting chemotaxis GH983_01645 ENOG4105C01 Dihydroxy-acid dehydratase GH983_01650 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GH983_01655 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GH983_01660 ENOG4105CJP fad dependent oxidoreductase GH983_01670 ENOG4105CBX hi0933 family GH983_01710 ENOG4107RUE extracellular solute-binding protein family 1 GH983_01715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_01720 ENOG4105F38 ABC transporter, permease GH983_01725 ENOG4105D38 putrescine abc transporter GH983_01740 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH983_01745 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component GH983_01755 ENOG4105BZU Histidine kinase GH983_01780 ENOG4105CM2 brancheD-chain amino acid aminotransferase GH983_01795 ENOG4105C26 Dehydrogenase GH983_01805 ENOG4108M3P Membrane GH983_01810 ENOG4105ERG peptidase m48, ste24p GH983_01820 ENOG4105KPV Transcriptional regulator GH983_01830 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GH983_01840 ENOG4105CJP fad dependent oxidoreductase GH983_01845 ENOG4105CFQ glutamine synthetase GH983_01855 ENOG4105WD1 Membrane GH983_01880 ENOG4105E0A ABC, transporter GH983_01885 ENOG4105TVJ transport system, permease GH983_01890 ENOG4105DQ5 transport system permease protein GH983_01895 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GH983_01900 ENOG4105E0K tonB-dependent siderophore receptor GH983_01930 ENOG4105ETE Transcriptional regulator (LacI family GH983_01940 ENOG4105F38 ABC transporter, permease GH983_01945 ENOG4105EG2 ABC transporter, permease GH983_01950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_01960 ENOG4105ECY inositol monophosphatase GH983_01965 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_01970 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GH983_02000 ENOG4108ZE9 Monovalent cation H antiporter subunit C GH983_02005 ENOG4107R4Z monovalent cation h antiporter subunit d GH983_02010 ENOG4105SC1 monovalent cation H antiporter subunit E GH983_02015 ENOG4105W4C monovalent cation H antiporter subunit F GH983_02020 ENOG4105KJM monovalent cation h antiporter subunit g GH983_02040 ENOG4105PE1 Receptor GH983_02045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_02050 ENOG4105BZU Histidine kinase GH983_02055 ENOG4105KJM monovalent cation h antiporter subunit g GH983_02070 ENOG4108JPZ Monovalent cation H antiporter subunit D GH983_02075 ENOG4108ZE9 Monovalent cation H antiporter subunit C GH983_02080 ENOG4105GND monovalent cation H antiporter subunit B GH983_02085 ENOG4105D65 subunit l GH983_02120 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GH983_02135 ENOG4105BZU Histidine kinase GH983_02155 ENOG4105CHH sulfate transporter GH983_02185 ENOG4108REF Sporulation integral membrane protein ytvi GH983_02200 ENOG4105C2J ABC transporter GH983_02205 ENOG4105CNN ABC, transporter GH983_02210 ENOG4105DKT Transcriptional regulator GH983_02215 ENOG4108FN7 Aldo keto reductase GH983_02225 ENOG41061GT Aldolase GH983_02230 ENOG4105CMG Carbohydrate kinase GH983_02250 ENOG4108IND Tetr family transcriptional regulator GH983_02255 ENOG4108WQI RNA Polymerase GH983_02270 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GH983_02280 ENOG4105BZU Histidine kinase GH983_02320 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GH983_02330 ENOG41089TF bicarbonate transport system substrate-binding protein GH983_02345 ENOG4105D7T ABC transporter GH983_02350 ENOG4108IFG nitrite reductase, (NAD(P)H) GH983_02365 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GH983_02375 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH983_02380 ENOG4105C4Y ABC transporter GH983_02385 ENOG4105C4Y ABC transporter GH983_02390 ENOG4107RCV ABC transporter, permease GH983_02395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_02405 ENOG4105D64 Mechanosensitive ion channel GH983_02415 ENOG4105DZQ phospholipase D Transphosphatidylase GH983_02430 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH983_02435 ENOG4105E0F Histidine kinase GH983_02460 ENOG4105W1Y Transcriptional regulator GH983_02490 ENOG4107Y80 Major Facilitator superfamily GH983_02495 ENOG4105C7F AcnD-accessory protein PrpF GH983_02515 ENOG4105DHQ Histidine kinase GH983_02520 ENOG4105S7S phosphonate abc transporter GH983_02525 ENOG4105D5T phosphonate abc transporter GH983_02535 ENOG4105FD8 phosphonate metabolism protein PhnM GH983_02540 ENOG4105FDP GntR family transcriptional regulator GH983_02550 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH983_02565 ENOG4105DIJ Phosphoethanolamine transferase GH983_02590 ENOG4105C9K Endothelin-converting enzyme 1 GH983_02605 ENOG4105ETT transcriptional Regulator, LysR family GH983_02650 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GH983_02655 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GH983_02670 ENOG4105C9X ppx gppa phosphatase GH983_02675 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GH983_02685 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH983_02715 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GH983_02750 ENOG4105C8Q Methyl-accepting chemotaxis GH983_02770 ENOG4105CJ3 phosphate transporter GH983_02780 ENOG4108E2B had-superfamily hydrolase, subfamily iib GH983_02785 ENOG4107STW synthase GH983_02790 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GH983_02795 ENOG4107QR9 Iron-sulfur cluster binding protein GH983_02800 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GH983_02820 ENOG4105HEI LysR family (Transcriptional regulator GH983_02825 ENOG4105CQB FAD linked oxidase domain protein GH983_02830 ENOG4105EU8 FAD linked oxidase domain protein GH983_02840 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GH983_02850 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_02855 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_02860 ENOG4108R3E Dna-3-methyladenine glycosylase i GH983_02895 ENOG4105CUT histidyl-tRNA synthetase GH983_02900 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit GH983_02905 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GH983_02910 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GH983_02915 ENOG4108VBZ doxx family GH983_02920 ENOG4105CYM Glutathione S-transferase GH983_02930 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GH983_02935 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GH983_02950 ENOG4105DTN riboflavin biosynthesis protein ribF GH983_02980 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GH983_02990 ENOG4105K5X acetyltransferase GH983_03000 ENOG4108Z6B deaminase GH983_03005 ENOG4105FE9 pseudouridine synthase GH983_03010 ENOG4106H78 methyltransferase GH983_03015 ENOG4105D78 K07001 NTE family protein GH983_03025 ENOG4105CMS peptidase U62, modulator of DNA gyrase GH983_03040 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GH983_03050 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GH983_03060 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GH983_03065 ENOG4105BZU Histidine kinase GH983_03070 ENOG4105BZU Histidine kinase GH983_03075 ENOG4105ETT transcriptional Regulator, LysR family GH983_03080 ENOG4105F5V trimethylamine methyltransferase GH983_03095 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GH983_03100 ENOG4107WYG Transcriptional regulator, luxr family GH983_03110 ENOG4107QUT magnesium and cobalt transport protein CorA GH983_03115 ENOG4105DFH Transport of potassium into the cell (By similarity) GH983_03130 ENOG4107PQ6 Inherit from NOG: atp synthase GH983_03135 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GH983_03140 ENOG4105VD1 ATP synthase subunit C GH983_03145 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GH983_03150 ENOG4105N5Q Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) GH983_03155 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GH983_03170 ENOG4108RIR Molybdenum cofactor biosynthesis protein GH983_03175 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GH983_03185 ENOG4105EAH synthase GH983_03210 ENOG4105BZU Histidine kinase GH983_03215 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GH983_03220 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_03225 ENOG4105BZU Histidine kinase GH983_03230 ENOG4108V0P LemA family GH983_03235 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GH983_03245 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GH983_03250 ENOG4105X54 addiction module antidote protein GH983_03260 ENOG4105EWC Purine nucleoside phosphorylase GH983_03265 ENOG4105C8Q Methyl-accepting chemotaxis GH983_03275 ENOG4105C12 Phosphoribosylglycinamide synthetase GH983_03280 ENOG4105BZM domain protein GH983_03295 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GH983_03310 ENOG4105TAV cytochrome C GH983_03315 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GH983_03345 ENOG4105W1Y Transcriptional regulator GH983_03370 ENOG4105Z4Q MltA-interacting MipA family protein GH983_03390 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GH983_03395 ENOG4105E0C molybdate abc transporter GH983_03400 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GH983_03405 ENOG4105F4R Transcriptional regulator mode GH983_03415 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GH983_03430 ENOG4105DVW rieske (2Fe-2S) GH983_03445 ENOG4105W6J BA14K family GH983_03455 ENOG4107QMS site-determining protein GH983_03460 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GH983_03470 ENOG4105CSU acyl-Coa dehydrogenase GH983_03480 ENOG4105C8Q Methyl-accepting chemotaxis GH983_03495 ENOG4107QS4 23S rRNA GH983_03505 ENOG4107SDU Methyl-accepting chemotaxis GH983_03520 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GH983_03525 ENOG4105DU1 integral membrane protein, terc GH983_03530 ENOG4108J5H Homocysteine s-methyltransferase GH983_03535 ENOG4105C28 cystathionine GH983_03545 ENOG4105DSP amino acid AbC transporter GH983_03555 ENOG4108JEH abc transporter atp-binding protein GH983_03580 ENOG4108VYJ response regulator receiver protein GH983_03585 ENOG4105CY2 Citrate transporter GH983_03590 ENOG4105EUB pirin domain protein GH983_03595 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GH983_03615 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH983_03640 ENOG4107ZYJ bioY protein GH983_03645 ENOG4107QCX Transporter GH983_03650 ENOG4108JJB ABC transporter GH983_03655 ENOG4105T0Z Conserved Protein GH983_03675 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GH983_03680 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GH983_03685 ENOG4105BZU Histidine kinase GH983_03695 ENOG4105CVJ phosphoglycerate mutase GH983_03700 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GH983_03705 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GH983_03715 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GH983_03725 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH983_03730 ENOG4108Z4X TRANSCRIPTIONal GH983_03735 ENOG4105DZ1 carboxypeptidase GH983_03750 ENOG4105D1U peptidase U62 modulator of DNA gyrase GH983_03760 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GH983_03765 ENOG4105BZ9 Cytochrome C oxidase, subunit I GH983_03770 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GH983_03780 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) GH983_03785 ENOG4107QS1 Cytochrome C Oxidase, Subunit III GH983_03795 ENOG4108R6F Surfeit locus 1 family protein GH983_03805 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GH983_03815 ENOG4105BZU Histidine kinase GH983_03820 ENOG4105CUV Homoserine Kinase GH983_03825 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GH983_03835 ENOG4105EHV domain protein GH983_03845 ENOG4108UJU UPF0301 protein GH983_03870 ENOG4105D9U N-acetyltransferase GH983_03875 ENOG4105C1V Peptidase, M16 GH983_03880 ENOG4105D98 threonine synthase GH983_03900 ENOG4105CBD Diacylglycerol kinase GH983_03905 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GH983_03935 ENOG4105YAJ CopG Arc MetJ GH983_03950 ENOG4105VKD bioY protein GH983_03965 ENOG4105EA8 2-Nitropropane dioxygenase GH983_03970 ENOG4105VSH 4-oxalocrotonate tautomerase GH983_03980 ENOG4108K3A Glutathione S-transferase GH983_03990 ENOG4105CEC DNA methylase N-4 N-6 GH983_03995 ENOG4105KCK Peptidoglycan-associated lipoprotein GH983_04005 ENOG4105CEN a g-specific adenine glycosylase GH983_04015 ENOG4105CHH sulfate transporter GH983_04020 ENOG4105CHH sulfate transporter GH983_04025 ENOG4105F8J Adenylate Guanylate cyclase GH983_04045 ENOG4106IEQ GH983_04055 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GH983_04065 ENOG4106UW1 Major Facilitator superfamily GH983_04075 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GH983_04080 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GH983_04090 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GH983_04105 ENOG4105MRR Transcriptional regulator (By similarity) GH983_04140 ENOG4107R7Y intracellular protease Pfpi family GH983_04150 ENOG4105BZ1 (ABC) transporter GH983_04160 ENOG4107QZ7 Cellulose synthase catalytic subunit GH983_04170 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) GH983_04180 ENOG4108IPW abc transporter atp-binding protein GH983_04185 ENOG4105CM4 permease protein GH983_04190 ENOG4105DHS permease protein GH983_04210 ENOG4108KPJ rna polymerase sigma factor GH983_04240 ENOG4105DIQ Transcriptional regulator GH983_04255 ENOG4107QK2 May be the GTPase, regulating ATP sulfurylase activity (By similarity) GH983_04260 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GH983_04265 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GH983_04270 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family GH983_04320 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_04355 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GH983_04360 ENOG4105C26 Dehydrogenase GH983_04365 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GH983_04370 ENOG4108M8H domain protein GH983_04385 ENOG4105BZU Histidine kinase GH983_04460 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH983_04465 ENOG4105C8Q Methyl-accepting chemotaxis GH983_04470 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_04475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_04495 ENOG4105EXU Membrane GH983_04500 ENOG4105K56 Transcriptional regulator GH983_04505 ENOG4108ZHJ Organic hydroperoxide resistance protein GH983_04540 ENOG4105K5G 30S ribosomal protein S21 GH983_04545 ENOG4105VEQ Cold shock protein GH983_04560 ENOG4105ECK Fatty Acid Desaturase GH983_04570 ENOG4108NIW Leucine export protein LeuE GH983_04585 ENOG4105KK4 UPF0060 membrane protein GH983_04595 ENOG4105D7A ATP-binding protein GH983_04620 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GH983_04650 ENOG4105W39 Membrane GH983_04685 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH983_04690 ENOG4108HWW ABC transporter GH983_04695 ENOG4105C2J ABC transporter GH983_04725 ENOG4108UT2 hemolysin iii GH983_04745 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GH983_04770 ENOG4105C9U ATP-dependent DNA helicase RecQ GH983_04795 ENOG4105E0X reductase GH983_04800 ENOG4105D65 subunit l GH983_04805 ENOG4105GND monovalent cation H antiporter subunit B GH983_04810 ENOG4108ZE9 Monovalent cation H antiporter subunit C GH983_04815 ENOG4108JPZ Monovalent cation H antiporter subunit D GH983_04825 ENOG41080TA Multiple resistance and ph regulation protein f GH983_04830 ENOG4105KJM monovalent cation h antiporter subunit g GH983_04835 ENOG4108YXV Transcriptional regulator GH983_04840 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GH983_04850 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GH983_04855 ENOG4105WZR GH983_04860 ENOG4105BZU Histidine kinase GH983_04875 ENOG4105C8Q Methyl-accepting chemotaxis GH983_04885 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression GH983_04905 ENOG4105CPI Metal Dependent Phosphohydrolase GH983_04930 ENOG4105KWG Pfam:DUF1696 GH983_04960 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GH983_04975 ENOG4106TD9 Diguanylate cyclase GH983_04980 ENOG4105BZU Histidine kinase GH983_04985 ENOG4108JQC penicillin-binding protein 1A GH983_04990 ENOG4108ZZ3 UPF0260 protein GH983_05020 ENOG4106TD9 Diguanylate cyclase GH983_05035 ENOG4105WDY DNA (cytosine-5-)-methyltransferase GH983_05190 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH983_05205 ENOG4106FI7 cytochrome c-type biogenesis protein GH983_05210 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GH983_05215 ENOG4105DA4 cytochrome c-type biogenesis protein GH983_05220 ENOG4105KWW Biogenesis protein GH983_05235 ENOG4105C0H protease GH983_05240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH983_05245 ENOG4105JJR Histidine kinase GH983_05250 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GH983_05260 ENOG4105BZU Histidine kinase GH983_05265 ENOG4105CD8 aminopeptidase N GH983_05270 ENOG4105C8Q Methyl-accepting chemotaxis GH983_05305 ENOG4105CFG Acts as a chaperone (By similarity) GH983_05320 ENOG4105CHR reductase GH983_05330 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH983_05335 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GH983_05340 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GH983_05345 ENOG4105KVH Transcriptional regulator GH983_05355 ENOG4105F7P transcriptional regulator AsnC family GH983_05365 ENOG4105F27 Major Facilitator GH983_05375 ENOG4108JQ5 ABC transporter GH983_05380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_05385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH983_05390 ENOG4107QSI ABC, transporter GH983_05395 ENOG4105CFQ glutamine synthetase GH983_05400 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH983_05435 ENOG4105FYV Amp nucleosidase GH983_05460 ENOG4105CIH Imidazole acetol-phosphate transaminase GH983_05505 ENOG4107SC1 transglycosylase GH983_05510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH983_05530 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GH983_05545 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH983_05555 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GH983_05575 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GH983_05580 ENOG4105C3F Signal peptidase i GH983_05585 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GH983_05590 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GH983_05595 ENOG4108KK1 membrane protein AbrB duplication GH983_05605 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) GH983_05625 ENOG4105EST Metal Dependent Phosphohydrolase GH983_05640 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GH983_05645 ENOG4108IYU L-aspartate oxidase GH983_05650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GH983_05660 ENOG4105D64 Mechanosensitive ion channel GH983_05675 ENOG4108R7K Metal Dependent Phosphohydrolase GH983_05680 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GH983_05700 ENOG4105PTV Nudix Hydrolase GH983_05710 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GH983_05715 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme GH983_05720 ENOG4105BZU Histidine kinase GH983_05725 ENOG4108JJ7 ABC transporter GH983_05735 ENOG4108URH decarboxylase GH983_05740 ENOG4105FR1 rard protein GH983_05745 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GH983_05775 ENOG4105C8N cysteinyl-tRNA synthetase GH983_05780 ENOG4105BZU Histidine kinase GH983_05790 ENOG4105PDP Short chain dehydrogenase GH983_05795 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GH983_05800 ENOG4105E96 Colicin v production protein GH983_05815 ENOG4105X54 addiction module antidote protein GH983_05820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GH983_05825 ENOG4105E7U AraC family transcriptional regulator GH983_05845 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GH983_05855 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GH983_05860 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GH983_05870 ENOG4105CPC Aldo Keto reductase GH983_05875 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GH983_05885 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GH983_05890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GH983_05895 ENOG4105HHA aminodeoxychorismate lyase GH983_05900 ENOG4105DSJ YicC domain protein GH983_05905 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GH983_05910 ENOG4105CBG Sulfatase GH983_05920 ENOG4105DND Transcriptional regulator GH983_05930 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GH983_05935 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GH983_05945 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GH983_05960 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GH983_05970 ENOG4105C8Q Methyl-accepting chemotaxis GH983_05975 ENOG4105C5H ABC transporter GH983_05990 ENOG4105C8Q Methyl-accepting chemotaxis GH983_06005 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GH983_06010 ENOG4108ZAF Molybdopterin GH983_06025 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GH983_06030 ENOG4105CHR reductase GH983_06035 ENOG4105JVC membrAne GH983_06050 ENOG4105D6S protein involved in catabolism of external DNA GH983_06055 ENOG4107QY8 reductase GH983_06065 ENOG4105BZ1 (ABC) transporter GH983_06070 ENOG4108V3E phosphoribosylglycinamide formyltransferase GH983_06075 ENOG4105CXB phosphoribosylaminoimidazole synthetase GH983_06080 ENOG4105C02 permease GH983_06090 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GH983_06095 ENOG4105C9X ppx gppa phosphatase GH983_06130 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GH983_06140 ENOG4105E3B Multicopper oxidase GH983_06170 ENOG4105C9M aspartyl-trna synthetase GH983_06180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH983_06190 ENOG4105BZU Histidine kinase GH983_06200 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GH983_06210 ENOG4105D52 delta-aminolevulinic acid dehydratase GH983_06235 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GH983_06240 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GH983_06245 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GH983_06260 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GH983_06265 ENOG4107XZX Involved in the transcription termination process (By similarity) GH983_06270 ENOG4105DXI Major Facilitator superfamily GH983_06275 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for GH983_06295 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GH983_06300 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GH983_06305 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GH983_06310 ENOG4105WJX transcriptional regulator MERR family GH983_06345 ENOG4107QPH glycogen) synthase GH983_06370 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GH983_06375 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GH983_06380 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GH983_06385 ENOG4105CYW agmatinase GH983_06390 ENOG4108UJD 30S ribosomal protein S9 GH983_06395 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GH983_06405 ENOG4105K4P CoA-binding domain protein GH983_06415 ENOG4105K4P CoA-binding domain protein GH983_06435 ENOG4108RXX maleylacetoacetate isomerase GH983_06440 ENOG4105D29 Helix-turn-helix type 11 domain protein GH983_06450 ENOG4108K0B C-di-gmp phosphodiesterase GH983_06455 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH983_06460 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GH983_06465 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GH983_06475 ENOG4108SXK Transporter Drug Metabolite Exporter family GH983_06485 ENOG4105CPC Aldo Keto reductase GH983_06495 ENOG4105CT4 transporter GH983_06500 ENOG4105C6Y Udp-glucose 6-dehydrogenase GH983_06510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH983_06535 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GH983_06540 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH983_06545 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GH983_06550 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH983_06560 ENOG4105GKE subunit e GH983_06565 ENOG4107QIZ NADH dehydrogenase GH983_06570 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GH983_06575 ENOG4107R0R NADH dehydrogenase subunit g GH983_06580 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GH983_06585 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH983_06590 ENOG4105DF2 NADH dehydrogenase subunit j GH983_06595 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH983_06600 ENOG4105D65 subunit l GH983_06605 ENOG4105C8S subunit m GH983_06610 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH983_06615 ENOG4108EKN Biotin protein ligase C terminal domain GH983_06635 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GH983_06645 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GH983_06650 ENOG4105C0B DNA polymerase III (alpha subunit) GH983_06665 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GH983_06680 ENOG4108UXN response regulator GH983_06685 ENOG4105BZU Histidine kinase GH983_06690 ENOG4105W0E 50S ribosomal protein L33 GH983_06695 ENOG4108ISG Major Facilitator GH983_06705 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GH983_06720 ENOG4105C79 DNA protecting protein DprA GH983_06725 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GH983_06730 ENOG4105CD3 dihydroorotase GH983_06735 ENOG4105CXT aspartate transcarbamylase GH983_06740 ENOG4105CSU acyl-Coa dehydrogenase GH983_06760 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GH983_06765 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GH983_06770 ENOG4107T8T UPF0173 metal-dependent hydrolase GH983_06775 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GH983_06780 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GH983_06800 ENOG4105YCT UPF0386 protein GH983_06805 ENOG4108YM7 Gcn5-related n-acetyltransferase GH983_06815 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GH983_06860 ENOG4105BZ9 Cytochrome C oxidase, subunit I GH983_06865 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) GH983_06885 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GH983_06905 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GH983_06910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GH983_06915 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GH983_06920 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GH983_06940 ENOG4105C03 ribonuclease GH983_06945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GH983_06970 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GH983_06985 ENOG4105C3Q Glycosyl transferase, family 2 GH983_06990 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase GH983_06995 ENOG4105C2N RNA methyltransferase TrmH family group 3 GH983_07010 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GH983_07045 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GH983_07050 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GH983_07055 ENOG4108VZM 50s ribosomal protein L10 GH983_07060 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GH983_07065 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GH983_07070 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GH983_07080 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GH983_07085 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GH983_07090 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GH983_07095 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GH983_07100 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GH983_07105 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GH983_07110 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GH983_07115 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GH983_07120 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GH983_07125 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GH983_07130 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GH983_07135 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GH983_07140 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GH983_07145 ENOG41083MP 50s ribosomal protein l29 GH983_07150 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GH983_07155 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GH983_07160 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GH983_07165 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GH983_07170 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GH983_07175 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GH983_07180 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GH983_07185 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GH983_07190 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GH983_07195 ENOG41084HQ 50S ribosomal protein L30 GH983_07200 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GH983_07205 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GH983_07210 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GH983_07215 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GH983_07220 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GH983_07225 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GH983_07230 ENOG4108ZT0 50S ribosomal protein l17 GH983_07240 ENOG4105CHP RNA polymerase GH983_07250 ENOG4105GRZ Ycii-related protein GH983_07255 ENOG4105NX3 Membrane GH983_07275 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) GH983_07280 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) GH983_07290 ENOG4105C01 Dihydroxy-acid dehydratase GH983_07295 ENOG4105FB2 class II Aldolase GH983_07305 ENOG4105ETT transcriptional Regulator, LysR family GH983_07315 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GH983_07330 ENOG4105C0H protease GH983_07335 ENOG4105D1H recombination factor protein RarA GH983_07340 ENOG4105BZU Histidine kinase GH983_07365 ENOG4107RTZ reductase GH983_07375 ENOG4105K4T epimerase GH983_07380 ENOG4108TM9 integral membrane protein GH983_07410 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GH983_07420 ENOG4105CEV competence damage-inducible protein GH983_07425 ENOG4105CS1 NAD(P)H quinone oxidoreductase GH983_07440 ENOG4107Z6I Thiamine biosynthesis protein GH983_07450 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component GH983_07460 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GH983_07465 ENOG4105C7B Threonine dehydratase GH983_07480 ENOG4105BZU Histidine kinase GH983_07485 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GH983_07490 ENOG4105F52 Transcriptional regulator GH983_07495 ENOG4105CGH 5'-nucleotidase GH983_07510 ENOG4108YXU transcriptional regulator AsnC family GH983_07515 ENOG4105DCF alanine dehydrogenase GH983_07525 ENOG4105DWP Membrane GH983_07540 ENOG4105KHC sulfurtransferase GH983_07545 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GH983_07565 ENOG4105KRQ Addiction module toxin, Txe YoeB family GH983_07575 ENOG4105CVP deoxyribo-dipyrimidine photolyase GH983_07605 ENOG4108KE4 O-methyltransferase GH983_07615 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GH983_07625 ENOG4108P7N Exopolysaccharide production negative regulator GH983_07635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GH983_07640 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GH983_07645 ENOG4105C75 arginyL-tRNA synthetase GH983_07665 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GH983_07670 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_07675 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GH983_07680 ENOG4108CE5 Inherit from COG: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GH983_07685 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GH983_07690 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GH983_07695 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GH983_07700 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GH983_07705 ENOG4108K5P (LipO)protein GH983_07740 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GH983_07750 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GH983_07755 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GH983_07775 ENOG4105DHZ alpha beta GH983_07780 ENOG4105C3J Cysteine desulfurase GH983_07795 ENOG4105JRK feS assembly protein SufD GH983_07800 ENOG4105C9B Cysteine desulfurase GH983_07805 ENOG4105VG1 fes assembly suf system protein GH983_07810 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GH983_07815 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GH983_07820 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) GH983_07825 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GH983_07830 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) GH983_07835 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GH983_07875 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GH983_07880 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GH983_07885 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GH983_07910 ENOG41082CG Protein CrcB homolog GH983_07915 ENOG4105EI2 Pseudouridine synthase GH983_07920 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GH983_07975 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase GH983_07980 ENOG4105DVK Precorrin-2 c20-methyltransferase GH983_07990 ENOG4105CIA precorrin-4 C(11)-methyltransferase GH983_07995 ENOG4105DU0 nucleoside hydrolase GH983_08020 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GH983_08025 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GH983_08040 ENOG4105W5Q DNA repair protein (RadC GH983_08045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GH983_08055 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GH983_08065 ENOG4105CHM Aminotransferase GH983_08070 ENOG4105D6E homoserine dehydrogenase GH983_08080 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GH983_08110 ENOG4105VEQ Cold shock protein GH983_08140 ENOG4105CDA abc transporter atp-binding protein GH983_08145 ENOG4105DRP amino acid AbC transporter GH983_08150 ENOG4105EZ7 amino acid ABC transporter GH983_08155 ENOG4107QXX ABC transporter GH983_08160 ENOG4105C28 cystathionine GH983_08175 ENOG4105D74 hydrolase GH983_08180 ENOG4106YT9 Enoyl-CoA hydratase GH983_08185 ENOG4105D7W serine acetyltransferase GH983_08200 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GH983_08225 ENOG4105K59 histidine triad (HIT) protein GH983_08250 ENOG4105CE9 30S ribosomal protein S2 GH983_08255 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GH983_08260 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GH983_08265 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GH983_08270 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GH983_08280 ENOG4105DZP Membrane-associated zinc metalloprotease GH983_08285 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GH983_08290 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH983_08295 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GH983_08300 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH983_08305 ENOG4105GYT Protein of unknown function (DUF1009) GH983_08310 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH983_08315 ENOG4105CKI cobalamin synthesis protein GH983_08320 ENOG4105NXV High-affinity zinc uptake system protein GH983_08325 ENOG4105FDK ABC transporter GH983_08330 ENOG4105FAV ABC, transporter GH983_08335 ENOG4105MYN Zinc uptake regulation protein GH983_08340 ENOG4108Z0R Transferase GH983_08350 ENOG4105DZ1 carboxypeptidase GH983_08375 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GH983_08380 ENOG4105D78 K07001 NTE family protein GH983_08385 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GH983_08390 ENOG4105EUJ GTP cyclohydrolase i GH983_08400 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GH983_08410 ENOG4105C22 threonyL-tRNA synthetase GH983_08425 ENOG41069NU Nitroreductase GH983_08445 ENOG4105IPI Membrane GH983_08450 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH983_08460 ENOG4105CP7 Triose-phosphate isomerase GH983_08470 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GH983_08475 ENOG4105CVM Molybdenum cofactor synthesis domain protein GH983_08480 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GH983_08485 ENOG4105DK0 Indole-3-glycerol phosphate synthase GH983_08490 ENOG4108I0Q anthranilate phosphoribosyltransferase GH983_08510 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GH983_08525 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GH983_08530 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GH983_08540 ENOG4108JYK Dehydrogenase GH983_08545 ENOG4105CPP Dehydrogenase, E1 component GH983_08550 ENOG4105C7S Dehydrogenase GH983_08565 ENOG4107QN2 dihydrolipoyl dehydrogenase GH983_08575 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GH983_08605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GH983_08615 ENOG4105CUX Signal transduction histidine kinase GH983_08620 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_08625 ENOG4105ES5 Histidine kinase GH983_08630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_08635 ENOG4105C1A potassium transporter peripheral membrane GH983_08640 ENOG4105F0I Aminotransferase GH983_08645 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GH983_08650 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GH983_08655 ENOG4105EPH radical SAM domain protein GH983_08660 ENOG4105I29 Bacteriochlorophyll 4-vinyl reductase GH983_08670 ENOG4105DXN mazG family GH983_08680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GH983_08700 ENOG4105DP0 ferredoxin-NADP reductase GH983_08715 ENOG4108IJ7 Glycine betaine GH983_08720 ENOG4108HQS Glycine betaine GH983_08740 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GH983_08750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GH983_08770 ENOG4105BZU Histidine kinase GH983_08775 ENOG4105BZU Histidine kinase GH983_08785 ENOG41083Z3 extracellular ligand-binding receptor GH983_08790 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GH983_08800 ENOG4105C0Z ABC transporter GH983_08805 ENOG4108IV0 ABC, transporter GH983_08830 ENOG4105DZ1 carboxypeptidase GH983_08835 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GH983_08840 ENOG4107QRG dna polymerase iii GH983_08845 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GH983_08850 ENOG4105F8V Hydrolase, tatD family GH983_08870 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GH983_08875 ENOG4108ERU trap dicarboxylate transporter subunit DctP GH983_08880 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GH983_08885 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_08895 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GH983_08900 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GH983_08905 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GH983_08910 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GH983_08915 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GH983_08935 ENOG41081FY multiple antibiotic resistance (MarC)-related GH983_08940 ENOG4108UUM single-stranded DNA-binding protein GH983_08945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GH983_08955 ENOG4105EAM Na Pi-cotransporter GH983_08960 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GH983_08970 ENOG4105C5F glutamine synthetase GH983_08990 ENOG4105E43 Extracellular solute-binding protein, family 5 GH983_09000 ENOG4105DFI Membrane GH983_09015 ENOG4105CB5 ATP-dependent DNA helicase recG GH983_09025 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GH983_09030 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GH983_09035 ENOG4107EJG GntR family transcriptional regulator GH983_09055 ENOG4105C2J ABC transporter GH983_09060 ENOG4105VE1 Phosphatidylcholine synthase GH983_09070 ENOG4105RK9 auxin efflux carrier GH983_09075 ENOG4107QIV Cytochrome c biogenesis protein GH983_09085 ENOG4108QMY dioxygenase GH983_09095 ENOG4105KVH Transcriptional regulator GH983_09100 ENOG4105DJY efflux transporter, rnd family, mfp subunit GH983_09105 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH983_09110 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH983_09120 ENOG4108T58 Mg2 transport protein CorA GH983_09130 ENOG4105F5V trimethylamine methyltransferase GH983_09135 ENOG4108Q52 Methyltransferase cognate corrinoid protein GH983_09200 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GH983_09220 ENOG4105CVJ phosphoglycerate mutase GH983_09245 ENOG4105ECQ AraC Family Transcriptional Regulator GH983_09255 ENOG4105HF0 Membrane GH983_09265 ENOG4105C8Q Methyl-accepting chemotaxis GH983_09270 ENOG4105NAU thioesterase Superfamily protein GH983_09290 ENOG4105BZU Histidine kinase GH983_09300 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GH983_09320 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GH983_09325 ENOG4105VEQ Cold shock protein GH983_09330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GH983_09355 ENOG4105EJQ L-serine dehydratase GH983_09380 ENOG4105CJW magnesium transporter GH983_09385 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GH983_09400 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GH983_09415 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GH983_09440 ENOG4107QPD alcohol dehydrogenase GH983_09450 ENOG4108UPT UPF0178 protein GH983_09455 ENOG4105C4W S-formylglutathione hydrolase GH983_09465 ENOG4105DSG hydrolase family 43 GH983_09470 ENOG4105CPC Aldo Keto reductase GH983_09475 ENOG4107VPB domain protein GH983_09495 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GH983_09500 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GH983_09515 ENOG4105BZU Histidine kinase GH983_09525 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GH983_09590 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GH983_09600 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GH983_09605 ENOG4105J3Q acyl carrier protein GH983_09610 ENOG4105D4P Coproporphyrinogen iii oxidase GH983_09615 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GH983_09640 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GH983_09655 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH983_09660 ENOG4105ED9 Protein of unknown function (DUF455) GH983_09665 ENOG4105DR5 peptidase GH983_09670 ENOG4105C1J atp-dependent rna helicase GH983_09690 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family GH983_09705 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GH983_09710 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GH983_09720 ENOG4105CHR reductase GH983_09725 ENOG4105DJV ribulose-phosphate 3-epimerase GH983_09740 ENOG4105C83 adenylosuccinate lyase GH983_09755 ENOG4105R0I Feruloyl esterase GH983_09775 ENOG4107QPR SAICAR synthetase GH983_09780 ENOG410839H phosphoribosylformylglycinamidine synthase GH983_09790 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GH983_09805 ENOG4107SQD Transcriptional regulator, GntR family GH983_09810 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GH983_09835 ENOG4105C2C drug resistance transporter, Bcr CflA GH983_09840 ENOG4105ECY inositol monophosphatase GH983_09860 ENOG4108MWI inositol mono-phosphatase GH983_09865 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GH983_09870 ENOG4105CSV Glutaminase GH983_09875 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GH983_09880 ENOG4105DZ1 carboxypeptidase GH983_09885 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GH983_09910 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GH983_09915 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GH983_09940 ENOG4105CHH sulfate transporter GH983_09950 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GH983_09955 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GH983_09965 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GH983_09980 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GH983_09990 ENOG4105CM6 amino acid regulated cytosolic protein GH983_09995 ENOG4106K28 UPF0283 membrane protein GH983_10005 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GH983_10015 ENOG4105EEI dihydropteroate synthase GH983_10025 ENOG4107Z7P Ferredoxin GH983_10050 ENOG4105DHJ ABC, transporter GH983_10055 ENOG4105CY3 ABC transporter, permease GH983_10065 ENOG4105C6K Malic enzyme GH983_10085 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase GH983_10090 ENOG4108MR6 WD40-like Beta Propeller Repeat GH983_10100 ENOG4105C4K Nad synthetase GH983_10105 ENOG4107T7U Sulfatase GH983_10120 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase GH983_10140 ENOG4105E66 phosphoriboisomerase A GH983_10145 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GH983_10155 ENOG4105C9Q fumarate hydratase class II GH983_10165 ENOG4107GFK fumarate GH983_10170 ENOG4105BZU Histidine kinase GH983_10185 ENOG4105NTK Transcriptional repressor Mpra GH983_10195 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GH983_10215 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GH983_10220 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GH983_10225 ENOG4105KCK Peptidoglycan-associated lipoprotein GH983_10230 ENOG4105E89 ABC transporter GH983_10245 ENOG4105P0T Usg family GH983_10265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH983_10275 ENOG4108XM1 transcriptional regulator AsnC family GH983_10280 ENOG4108RG0 uracil-dna glycosylase GH983_10290 ENOG4105BZU Histidine kinase GH983_10300 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GH983_10305 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GH983_10320 ENOG4105E3A (ABC) transporter GH983_10325 ENOG4105DA5 (ABC) transporter GH983_10330 ENOG4105BZU Histidine kinase GH983_10335 ENOG4108VYJ response regulator receiver protein GH983_10345 ENOG4105EGS Mechanosensitive ion channel GH983_10360 ENOG4107R4I Periplasmic binding protein GH983_10365 ENOG4105EHG Permease protein GH983_10370 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GH983_10380 ENOG4105JAB phenazine biosynthesis protein, phzf family GH983_10395 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH983_10405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GH983_10445 ENOG4108UYU AsnC family transcriptional regulator GH983_10455 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GH983_10475 ENOG4107SID ATP-dependent exodnase (exonuclease v) GH983_10500 ENOG4105CV8 reductase GH983_10505 ENOG41082BM Transcriptional regulator, arsr family GH983_10510 ENOG4108ZP8 Acetolactate synthase small subunit GH983_10515 ENOG4105C7K acetolactate synthase GH983_10525 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GH983_10530 ENOG4105EAC phosphoserine phosphatase GH983_10535 ENOG4108YYQ gCN5-related N-acetyltransferase GH983_10540 ENOG4105BZU Histidine kinase GH983_10555 ENOG4105EPW hflc protein GH983_10560 ENOG4107QJR hflk protein GH983_10570 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GH983_10600 ENOG4105CQB FAD linked oxidase domain protein GH983_10605 ENOG4105BZS acriflavin resistance protein GH983_10625 ENOG4107104 thymidine kinase GH983_10635 ENOG4105DZG Dehydrogenase GH983_10640 ENOG4108RWI nicotinamidase GH983_10645 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GH983_10650 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GH983_10675 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GH983_10680 ENOG4108ZX6 Electron transport protein SCO1 SenC GH983_10700 ENOG4108V3W Chemotaxis protein, CheW GH983_10720 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GH983_10725 ENOG4105C1J atp-dependent rna helicase GH983_10740 ENOG4105BZU Histidine kinase GH983_10745 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GH983_10755 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GH983_10765 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GH983_10770 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GH983_10775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GH983_10780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GH983_10785 ENOG4108UFP Essential cell division protein (By similarity) GH983_10790 ENOG4105CPF Cell wall formation (By similarity) GH983_10795 ENOG4105BZU Histidine kinase GH983_10800 ENOG4105D4A Cell wall formation (By similarity) GH983_10805 ENOG4105DFU Cell wall formation (By similarity) GH983_10810 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GH983_10820 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GH983_10825 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GH983_10835 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GH983_10850 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GH983_10855 ENOG4108206 Cell division protein mraZ GH983_10875 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GH983_10880 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GH983_10905 ENOG4105BZU Histidine kinase GH983_10930 ENOG4105SYT Methylenetetrahydrofolate reductase GH983_10940 ENOG4105C8Q Methyl-accepting chemotaxis GH983_10955 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GH983_10960 ENOG4105C7K acetolactate synthase GH983_10970 ENOG4107RT3 EamA-like transporter family GH983_10995 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein GH983_11020 ENOG4105C5F glutamine synthetase GH983_11025 ENOG4105CH5 extracellular solute-binding protein, family 7 GH983_11030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_11045 ENOG4106KNT transcriptional regulator GH983_11060 ENOG4108I5D sulfate abc transporter GH983_11095 ENOG4105C3R Methionine synthase GH983_11100 ENOG4107QKS N-acylglucosamine 2-epimerase GH983_11105 ENOG4105MPN Membrane GH983_11165 ENOG4105C32 Amino acid ABC transporter (Permease) GH983_11170 ENOG4108IV0 ABC, transporter GH983_11175 ENOG4105C0Z ABC transporter GH983_11180 ENOG4108WYP Transcriptional regulator GH983_11215 ENOG4107RSM transcriptional regulator GH983_11225 ENOG4108SXK Transporter Drug Metabolite Exporter family GH983_11235 ENOG4105NXH GreA GreB family elongation factor GH983_11295 ENOG4108W3Y Transcriptional regulator, Crp Fnr family GH983_11325 ENOG4105D4P Coproporphyrinogen iii oxidase GH983_11335 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GH983_11345 ENOG4108VKQ nitriC oxide reductase GH983_11375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH983_11395 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GH983_11410 ENOG4105CFP Peptidase U32 GH983_11415 ENOG4106RZ4 Peptidase U32 GH983_11420 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GH983_11435 ENOG4105BZU Histidine kinase GH983_11450 ENOG4105CEI nitrite reductase GH983_11465 ENOG4107R16 Multicopper oxidase GH983_11490 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GH983_11500 ENOG4106P19 photosystem i assembly btpa GH983_11505 ENOG4108RVA ribokinase GH983_11515 ENOG41080QX K07048 phosphotriesterase-related protein GH983_11520 ENOG4105CNN ABC, transporter GH983_11525 ENOG4105C2J ABC transporter GH983_11530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH983_11535 ENOG4105ETE Transcriptional regulator (LacI family GH983_11545 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GH983_11550 ENOG4105DUM transcriptional regulator, lysR family GH983_11555 ENOG4105MWK D-amino acid dehydrogenase, small subunit GH983_11565 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GH983_11570 ENOG4105C26 Dehydrogenase GH983_11575 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GH983_11580 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH983_11585 ENOG4105E5Q amino acid AbC transporter GH983_11640 ENOG4105FT8 Phosphonate metabolism GH983_11645 ENOG4105ENV phosphonate C-P lyase system protein PhnK GH983_11650 ENOG4105HRV phosphonate c-p lyase system protein phnl GH983_11655 ENOG4105CPN adenine deaminase GH983_11660 ENOG4105D5T phosphonate abc transporter GH983_11695 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GH983_11710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_11725 ENOG4105E98 transcriptional regulator DeoR family GH983_11740 ENOG4108HQS Glycine betaine GH983_11760 ENOG4108KN0 Choline kinase GH983_11765 ENOG4105DZC cytosine deaminase GH983_11780 ENOG4105D7T ABC transporter GH983_11795 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GH983_11820 ENOG4105DHU Bile acid GH983_11825 ENOG41090KR LysR family transcriptional Regulator GH983_11850 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GH983_11895 ENOG41090KN UPF0303 protein GH983_11915 ENOG4105CH2 amidohydrolase GH983_11935 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH983_11945 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GH983_11965 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GH983_11970 ENOG4107QI1 Mate efflux family protein GH983_11980 ENOG4105CGZ zinc metallopeptidase GH983_12000 ENOG4105CPQ Dehydrogenase GH983_12010 ENOG4105C8Q Methyl-accepting chemotaxis GH983_12025 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GH983_12055 ENOG4105BZU Histidine kinase GH983_12060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH983_12080 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GH983_12095 ENOG4105F7P transcriptional regulator AsnC family GH983_12100 ENOG4105C3M thioredoxin reductase GH983_12105 ENOG4105EQ2 LysR family Transcriptional regulator GH983_12115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GH983_12150 ENOG4105D8V Glucose sorbosone dehydrogenase GH983_12155 ENOG4105CHM Aminotransferase GH983_12180 ENOG4105C5X domain protein GH983_12190 ENOG41090HR transcriptional regulator GH983_12195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH983_12200 ENOG4105E0F Histidine kinase GH983_12205 ENOG4108Z7R Chaperone CsaA GH983_12210 ENOG4105II7 pyrroline-5-carboxylate reductase GH983_12225 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GH983_12235 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GH983_12250 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GH983_12260 ENOG4105C8Q Methyl-accepting chemotaxis GH983_12270 ENOG4105C26 Dehydrogenase GH983_12280 ENOG4105BZU Histidine kinase GH983_12285 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GH983_12290 ENOG4105BZU Histidine kinase GH983_12300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GH983_12305 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GH983_12320 ENOG4108UQ8 endoribonuclease L-psp GH983_12330 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GH983_12335 ENOG4105C3G gtp-binding protein GH983_12375 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GH983_12380 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GH983_12390 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GH983_12395 ENOG4105BZ1 (ABC) transporter GH983_12420 ENOG4105BZ1 (ABC) transporter GH983_12425 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GH983_12445 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GH983_12465 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GH983_12480 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GH983_12505 ENOG4105VEV -acetyltransferase GH983_12520 ENOG4105CHF Glutathione S-transferase GH983_12525 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GH983_12535 ENOG4107TTQ Alpha beta hydrolase fold GH983_12540 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GH983_12560 ENOG4105DKK Benzoate GH983_12565 ENOG4105BZU Histidine kinase GH983_12570 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GH983_12610 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH983_12615 ENOG4108ESY Metal dependent phosphohydrolase GH983_12620 ENOG4108ESY Metal dependent phosphohydrolase GH983_12630 ENOG4105EW9 transcriptional regulator AsnC family GH983_12640 ENOG4105BZU Histidine kinase GH983_12645 ENOG4107RGH Aldehyde dehydrogenase GH983_12670 ENOG4105CNG UPF0061 protein GH983_12710 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GH983_12735 ENOG4105CRQ synthase (Component I) GH983_12745 ENOG4107ENK receptor GH983_12750 ENOG4105CKU formyltetrahydrofolate synthetase GH983_12755 ENOG4105C26 Dehydrogenase GH983_12760 ENOG4105EW9 transcriptional regulator AsnC family GH983_12765 ENOG4105VJY transcriptional regulator GH983_12805 ENOG4105G9V cytochrome C GH983_12815 ENOG4108HQS Glycine betaine GH983_12820 ENOG4108IJ7 Glycine betaine GH983_12830 ENOG41080HT Transcriptional regulator, arsr family GH983_12835 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH983_12855 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GH983_12880 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) GH983_12890 ENOG4105CPN adenine deaminase GH983_12905 ENOG4105KRQ Addiction module toxin, Txe YoeB family GH983_12920 ENOG4105CG3 alpha amylase, catalytic region GH983_12925 ENOG4107RA4 Glycosyl transferase (Group 1 GH983_12930 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GH983_12965 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GH983_12985 ENOG4105C7W Xanthine dehydrogenase GH983_13000 ENOG4105ETT transcriptional Regulator, LysR family GH983_13010 ENOG4107QUY Guanine deaminase GH983_13020 ENOG4105DMF Dehydrogenase GH983_13035 ENOG4108Z2U ureidoglycolate hydrolase GH983_13040 ENOG4107QI1 Mate efflux family protein GH983_13050 ENOG4107R5B glutamine synthetase GH983_13060 ENOG4105DHG Allantoate amidinohydrolase GH983_13065 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GH983_13070 ENOG4105DQ4 alcohol dehydrogenase GH983_13080 ENOG4108MGI Transcriptional regulator GH983_13090 ENOG4108TXN phosphonate metabolism protein GH983_13095 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GH983_13100 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GH983_13105 ENOG4105BZU Histidine kinase GH983_13110 ENOG4105F5V trimethylamine methyltransferase GH983_13115 ENOG4105C8Q Methyl-accepting chemotaxis GH983_13130 ENOG4105F1N DNA alkylation repair GH983_13140 ENOG4105C1J atp-dependent rna helicase GH983_13180 ENOG4105CEY Amp-dependent synthetase and ligase GH983_13185 ENOG4105C09 Bile acid GH983_13210 ENOG4105CMR udp-glucose 4-epimerase GH983_13220 ENOG4105C5H ABC transporter GH983_13225 ENOG4108Z18 K06886 hemoglobin GH983_13245 ENOG4105BZ8 glutamate synthase GH983_13250 ENOG4107SJI Dehydrogenase GH983_13255 ENOG4105BZU Histidine kinase GH983_13260 ENOG4108TPP exopolysaccharide synthesis GH983_13270 ENOG4108R86 Transcriptional regulator GH983_13275 ENOG4105CE7 Amidase, hydantoinase carbamoylase family GH983_13280 ENOG4105CD3 dihydroorotase GH983_13305 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH983_13310 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH983_13315 ENOG4105D2X ABC transporter substrate-binding protein GH983_13320 ENOG4105DJY efflux transporter, rnd family, mfp subunit GH983_13330 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GH983_13335 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GH983_13340 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GH983_13345 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) GH983_13350 ENOG4105BZU Histidine kinase GH983_13360 ENOG4105CQM Urea amidohydrolase subunit alpha GH983_13365 ENOG4106ISJ urease accessory protein GH983_13370 ENOG4105VTN Protein of unknown function (DUF1311) GH983_13375 ENOG4105KI2 Urea amidohydrolase subunit beta GH983_13380 ENOG4108YZ9 Urea amidohydrolase subunit gamma GH983_13385 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GH983_13395 ENOG4108IV0 ABC, transporter GH983_13400 ENOG4105C0Z ABC transporter GH983_13410 ENOG4105C32 Amino acid ABC transporter (Permease) GH983_13420 ENOG4108YNN Heme oxygenase GH983_13425 ENOG4105BZU Histidine kinase GH983_13435 ENOG4105BZU Histidine kinase GH983_13440 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GH983_13450 ENOG4105CP9 extracellular ligand-binding receptor GH983_13460 ENOG4108IV0 ABC, transporter GH983_13465 ENOG4105C0Z ABC transporter GH983_13470 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GH983_13475 ENOG4105C32 Amino acid ABC transporter (Permease) GH983_13485 ENOG4105DIN metallophosphoesterase GH983_13495 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GH983_13500 ENOG4105WIU sarcosine oxidase delta subunit GH983_13505 ENOG4105DDR sarcosine oxidase (Beta subunit) GH983_13510 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GH983_13535 ENOG410830R acetyltransferase GH983_13550 ENOG4105EFQ Two component transcriptional regulator (Winged helix family GH983_13575 ENOG4105FCS tRNA rRNA methyltransferase GH983_13590 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH983_13600 ENOG4105CJ1 ABC, transporter GH983_13610 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GH983_13615 ENOG4108IPJ Membrane GH983_13620 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GH983_13640 ENOG4105MWK D-amino acid dehydrogenase, small subunit GH983_13645 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GH983_13685 ENOG4105CK2 sodium dicarboxylate symporter GH983_13695 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_13700 ENOG4105DG4 malate L-lactate dehydrogenase GH983_13705 ENOG4105CNV Aldolase GH983_13715 ENOG4107S8C mandelate racemase muconate lactonizing GH983_13720 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GH983_13745 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GH983_13760 ENOG410870W N-acetyltransferase GH983_13770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH983_13775 ENOG4105C4M (Ubiquinol oxidase) subunit I GH983_13780 ENOG4108JQ1 Dehydrogenase GH983_13800 ENOG4105DEN Luciferase family GH983_13805 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GH983_13820 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GH983_13835 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GH983_13840 ENOG4105M6F mutator MutT protein GH983_13855 ENOG4107YD3 Thioesterase GH983_13860 ENOG4105E02 MotA TolQ exbB proton channel GH983_13865 ENOG4105SG9 biopolymer transport protein, ExbD GH983_13875 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GH983_13880 ENOG4105KCK Peptidoglycan-associated lipoprotein GH983_13890 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GH983_13895 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GH983_13900 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GH983_13905 ENOG4105CDY transcriptional regulatory protein GH983_13920 ENOG4108N3W hemolysin secretion protein GH983_13925 ENOG4105D48 metallophosphoesterase GH983_13930 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GH983_13985 ENOG4108R4U Hnh endonuclease GH983_14045 ENOG4105C94 Transporter GH983_14055 ENOG4105BZA Phosphoglycerate kinase GH983_14065 ENOG4105JAB phenazine biosynthesis protein, phzf family GH983_14095 ENOG41082FS 50S ribosomal protein L31 GH983_14100 ENOG4105BZ1 (ABC) transporter GH983_14110 ENOG4105UYK outer membrane protein a GH983_14120 ENOG4105ECY inositol monophosphatase GH983_14125 ENOG4107PU6 Membrane GH983_14145 ENOG4105MHT Transcriptional regulator, ARSR family GH983_14160 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GH983_14165 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GH983_14170 ENOG4105YK5 50S ribosomal protein L36 GH983_14175 ENOG4105M0T TPR Repeat-Containing Protein GH983_14185 ENOG4105CA9 Pyruvate kinase GH983_14205 ENOG4105Y2X UPF0335 protein GH983_14215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_14255 ENOG4105FE5 Homospermidine synthase GH983_14260 ENOG4105ZWB Outer membrane lipoprotein GH983_14265 ENOG4105CGH 5'-nucleotidase GH983_14270 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GH983_14285 ENOG4107QX8 SPFH domain, Band 7 family protein GH983_14305 ENOG4105C2X Arabinose 5-phosphate isomerase GH983_14320 ENOG4105CVE Lytic murein transglycosylase GH983_14365 ENOG4108ZNX Heat shock protein GH983_14375 ENOG4107TK4 histidinol-phosphate phosphatase GH983_14415 ENOG4105NPQ Pfam:DUF403 GH983_14430 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GH983_14435 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GH983_14440 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GH983_14445 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GH983_14450 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GH983_14465 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GH983_14475 ENOG4105CAU Arsenical resistance protein, ArsH GH983_14495 ENOG4105NFY transcriptional modulator of maze toxin, mazf GH983_14500 ENOG4106FC9 Protein of unknown function (DUF3018) GH983_14510 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GH983_14520 ENOG4105DDR sarcosine oxidase (Beta subunit) GH983_14525 ENOG4105K5G 30S ribosomal protein S21 GH983_14555 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_14560 ENOG4105CH5 extracellular solute-binding protein, family 7 GH983_14570 ENOG4105C5I Dehydrogenase GH983_14575 ENOG4105ETE Transcriptional regulator (LacI family GH983_14580 ENOG4107MII Sugar-specific transcriptional regulator TrmB GH983_14600 ENOG4105CKI cobalamin synthesis protein GH983_14610 ENOG4105C8Q Methyl-accepting chemotaxis GH983_14635 ENOG4105HEI LysR family (Transcriptional regulator GH983_14645 ENOG4105D7X high-affinity nickel-transporter GH983_14665 ENOG4108UHU Aldolase GH983_14680 ENOG4108JQ5 ABC transporter GH983_14685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_14690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH983_14695 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_14700 ENOG4105C72 UPF0176 protein GH983_14715 ENOG4108RCM Nitroreductase GH983_14720 ENOG4105KVH Transcriptional regulator GH983_14745 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH983_14750 ENOG4105CNN ABC, transporter GH983_14755 ENOG4105C2J ABC transporter GH983_14760 ENOG4105ETE Transcriptional regulator (LacI family GH983_14765 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GH983_14775 ENOG4105C93 Xylose Isomerase GH983_14780 ENOG4105CMG Carbohydrate kinase GH983_14785 ENOG4105ETE Transcriptional regulator (LacI family GH983_14795 ENOG4105CW7 secretion protein, HlyD family GH983_14800 ENOG4105YA8 Transcriptional regulator GH983_14805 ENOG4105EE5 Membrane protein terC GH983_14815 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GH983_14820 ENOG4105CRK lysyL-tRNA synthetase GH983_14835 ENOG4108MGI Transcriptional regulator GH983_14855 ENOG4105DIK (ABC) transporter GH983_14860 ENOG4105CC5 ABC transporter GH983_14865 ENOG4105CC5 ABC transporter GH983_14875 ENOG4105DFI Membrane GH983_14880 ENOG4107RSM transcriptional regulator GH983_14885 ENOG4107TYH extracellular solute-binding protein family 1 GH983_14890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_14895 ENOG4105D81 ABC transporter, permease GH983_14900 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GH983_14925 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GH983_14930 ENOG4105DKT Transcriptional regulator GH983_14945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH983_14975 ENOG4108JQ6 ABC transporter GH983_14980 ENOG4105CH2 amidohydrolase GH983_14995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_15000 ENOG410841Q phosphoesterase PA-phosphatase related protein GH983_15005 ENOG4105KXX peptidase s58 dmpa GH983_15020 ENOG4105FD8 phosphonate metabolism protein PhnM GH983_15025 ENOG4108IGT Dipeptidase GH983_15030 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GH983_15035 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_15040 ENOG4105F38 ABC transporter, permease GH983_15045 ENOG4105D38 putrescine abc transporter GH983_15050 ENOG4108HM4 ABC transporter GH983_15060 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GH983_15085 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GH983_15095 ENOG4105JVC membrAne GH983_15100 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GH983_15105 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GH983_15115 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GH983_15160 ENOG41074H6 response regulator GH983_15200 ENOG4105C5I Dehydrogenase GH983_15205 ENOG4105E39 Enoyl-CoA hydratase GH983_15220 ENOG4105CFF transcriptional regulator GH983_15225 ENOG4107QX3 carboxylase GH983_15230 ENOG4105CYM Glutathione S-transferase GH983_15265 ENOG4105F38 ABC transporter, permease GH983_15270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_15290 ENOG4105CYW agmatinase GH983_15295 ENOG4105ETT transcriptional Regulator, LysR family GH983_15300 ENOG4105CHM Aminotransferase GH983_15305 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GH983_15315 ENOG4105DH8 myo-inositol catabolism GH983_15330 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GH983_15335 ENOG4105D7K pfkb domain protein GH983_15360 ENOG4105FKQ transcriptional regulator GH983_15390 ENOG4105BZU Histidine kinase GH983_15400 ENOG4105ETX regulatoR GH983_15425 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH983_15430 ENOG4105CQZ Histidine kinase GH983_15455 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GH983_15460 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GH983_15480 ENOG4107XII Glycosyl Hydrolase Family 88 GH983_15485 ENOG4105EVH UPF0753 protein GH983_15490 ENOG4105D65 subunit l GH983_15495 ENOG4105DUM transcriptional regulator, lysR family GH983_15510 ENOG4108WQI RNA Polymerase GH983_15520 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase GH983_15525 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha GH983_15530 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta GH983_15535 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GH983_15540 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GH983_15545 ENOG4105DDW LysR family Transcriptional regulator GH983_15550 ENOG4107HP6 Transcriptional regulator GH983_15560 ENOG4107QNJ CoA-transferase subunit B GH983_15565 ENOG4105CHU acetyl-coa acetyltransferase GH983_15575 ENOG4105BZU Histidine kinase GH983_15580 ENOG4106N3A copper homeostasis protein cutc GH983_15595 ENOG4105E2D ec 3.2.1.52 GH983_15600 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GH983_15605 ENOG4106KNT transcriptional regulator GH983_15635 ENOG4108IJ9 (ABC) transporter GH983_15645 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GH983_15650 ENOG4105D56 permease protein GH983_15660 ENOG4105FDP GntR family transcriptional regulator GH983_15665 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GH983_15670 ENOG4105CE4 GlcNAc 6-P deacetylase GH983_15675 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GH983_15695 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GH983_15700 ENOG4105F38 ABC transporter, permease GH983_15710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_15720 ENOG4107EJG GntR family transcriptional regulator GH983_15725 ENOG41062B0 ABC transporter, permease GH983_15730 ENOG4107R9N ABC transporter GH983_15735 ENOG4105C2J ABC transporter GH983_15740 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GH983_15750 ENOG4108V3W Chemotaxis protein, CheW GH983_15765 ENOG41080HT Transcriptional regulator, arsr family GH983_15780 ENOG4105BZS acriflavin resistance protein GH983_15790 ENOG4107SV1 subunit D GH983_15795 ENOG41082A2 Alpha beta hydrolase GH983_15800 ENOG4105EWK phytoene GH983_15805 ENOG4105FE1 phytoene synthase GH983_15825 ENOG4105CTB Polyprenyl synthetase GH983_15830 ENOG4107EPK O-methyltransferase, family 2 GH983_15835 ENOG4107XHQ chlorophyll synthesis pathway, bchC GH983_15840 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) GH983_15845 ENOG41060GA Chlorophyllide reductase subunit Y GH983_15865 ENOG41068GY Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity) GH983_15885 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GH983_15890 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GH983_15900 ENOG4105FBB Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity) GH983_15925 ENOG4105XCI PucC protein GH983_15930 ENOG4108MIC Mg-protoporphyrin IX methyl transferase GH983_15935 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) GH983_15940 ENOG4105CTK cobaltochelatase, cobn subunit GH983_15950 ENOG4105C78 Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity) GH983_15955 ENOG4108VJI 2-vinyl bacteriochlorophyllide hydratase GH983_15965 ENOG4105D4D transcriptional regulator GH983_15970 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase GH983_15975 ENOG4105SS7 PucC protein GH983_15980 ENOG4107QZT geranylgeranyl reductase GH983_15990 ENOG4105KAV tspo and mbr like protein GH983_16000 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GH983_16020 ENOG4105FDP GntR family transcriptional regulator GH983_16030 ENOG4107QM2 Aldo Keto reductase GH983_16045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_16050 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GH983_16065 ENOG4105EYU Glutamine amido-transferase GH983_16070 ENOG4105M90 Glutamate synthase alpha subunit domain protein GH983_16075 ENOG4105CBC glutamate synthase GH983_16095 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GH983_16115 ENOG4105FKQ transcriptional regulator GH983_16140 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GH983_16145 ENOG4108IJ9 (ABC) transporter GH983_16150 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GH983_16155 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GH983_16170 ENOG4108VGW abc transporter atp-binding protein GH983_16175 ENOG4105CXZ ABC transporter, permease GH983_16180 ENOG4105VNH ABC transporter solute-binding protein GH983_16200 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GH983_16210 ENOG4107F9Y LysR family transcriptional regulator GH983_16230 ENOG41064T2 transcriptional regulator, lysR family GH983_16250 ENOG4105C0Z ABC transporter GH983_16255 ENOG4108IV0 ABC, transporter GH983_16260 ENOG4105C32 Amino acid ABC transporter (Permease) GH983_16265 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GH983_16300 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F GH983_16305 ENOG4105MRR Transcriptional regulator (By similarity) GH983_16325 ENOG4105C3U ABC transporter GH983_16330 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GH983_16340 ENOG4105C1G acyl-Coa dehydrogenase GH983_16345 ENOG4105CHU acetyl-coa acetyltransferase GH983_16355 ENOG4108K2B transcriptional regulator GH983_16360 ENOG4107R0V Pyruvate dehydrogenase GH983_16365 ENOG4105CPP Dehydrogenase, E1 component GH983_16370 ENOG4107QSN dihydrolipoamide acetyltransferase GH983_16375 ENOG4107QN2 dihydrolipoyl dehydrogenase GH983_16380 ENOG4105C1G acyl-Coa dehydrogenase GH983_16385 ENOG4107QX3 carboxylase GH983_16395 ENOG4105DJG MaoC domain protein dehydratase GH983_16405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_16435 ENOG4108JJA ABC, transporter GH983_16440 ENOG4108IJ6 ABC transporter GH983_16450 ENOG4108JJA ABC, transporter GH983_16480 ENOG4108WYP Transcriptional regulator GH983_16490 ENOG4105CD3 dihydroorotase GH983_16500 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_16510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_16515 ENOG4105C3U ABC transporter GH983_16530 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GH983_16540 ENOG4105CHR reductase GH983_16555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH983_16560 ENOG4105E0F Histidine kinase GH983_16565 ENOG4105CUC YeeE YedE family protein GH983_16575 ENOG4107S7U Sulfide dehydrogenase GH983_16595 ENOG4105CGH 5'-nucleotidase GH983_16625 ENOG4107QIV Cytochrome c biogenesis protein GH983_16650 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GH983_16655 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_16660 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH983_16665 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GH983_16670 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH983_16675 ENOG4105DHQ Histidine kinase GH983_16680 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GH983_16685 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GH983_16695 ENOG4108VCT Sulfite exporter TauE/SafE GH983_16715 ENOG4105C7W Xanthine dehydrogenase GH983_16720 ENOG4108WFR AraC Family Transcriptional Regulator GH983_16730 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH983_16760 ENOG4107QZ7 Cellulose synthase catalytic subunit GH983_16790 ENOG4105S0E allantoin catabolism protein GH983_16795 ENOG4105CDA abc transporter atp-binding protein GH983_16810 ENOG4105E89 ABC transporter GH983_16815 ENOG4105EAB amino acid AbC transporter GH983_16820 ENOG4105CPU Monooxygenase GH983_16830 ENOG4105DEN Luciferase family GH983_16835 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GH983_16840 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) GH983_16855 ENOG4105EVZ LysR family transcriptional regulator GH983_16860 ENOG4105DFI Membrane GH983_16865 ENOG4107QI1 Mate efflux family protein GH983_16915 ENOG4105C8V SAICAR synthetase GH983_16920 ENOG4105MKU Transcriptional regulator GH983_16925 ENOG4105C1P efflux transporter, rnd family, mfp subunit GH983_16940 ENOG4105W1Y Transcriptional regulator GH983_16945 ENOG4108JPW Aminotransferase GH983_16950 ENOG4105C26 Dehydrogenase GH983_16955 ENOG4107RSM transcriptional regulator GH983_16965 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GH983_16970 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GH983_17050 ENOG4105C8Y Acetylornithine aminotransferase GH983_17060 ENOG4108MGI Transcriptional regulator GH983_17065 ENOG4105CJP fad dependent oxidoreductase GH983_17070 ENOG4105C26 Dehydrogenase GH983_17085 ENOG4108ZZF transport protein (ExbD) GH983_17100 ENOG4108R6K riboflavin synthase, subunit alpha GH983_17115 ENOG4105KT7 mgtC SapB transporter GH983_17120 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GH983_17140 ENOG4105C1G acyl-Coa dehydrogenase GH983_17145 ENOG4105ETT transcriptional Regulator, LysR family GH983_17150 ENOG4105DN3 alpha-2-macroglobulin domain protein GH983_17155 ENOG4108JQB penicillin-binding protein 1C GH983_17200 ENOG4108TPP exopolysaccharide synthesis GH983_17215 ENOG4105HFZ Membrane GH983_17220 ENOG4105C9F isomerase GH983_17245 ENOG4105C2J ABC transporter GH983_17250 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GH983_17255 ENOG4105F5R ABC transporter GH983_17260 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GH983_17265 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GH983_17270 ENOG4108EHX EamA-like transporter family GH983_17275 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GH983_17280 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_17285 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter GH983_17295 ENOG4105DRR Transcriptional regulator, GntR family GH983_17300 ENOG4105CQB FAD linked oxidase domain protein GH983_17305 ENOG4105EXW epimerase dehydratase GH983_17310 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH983_17315 ENOG4105C01 Dihydroxy-acid dehydratase GH983_17325 ENOG41074H6 response regulator GH983_17355 ENOG4108IRC dna polymerase iii GH983_17365 ENOG4105W87 Cbs domain GH983_17370 ENOG4107QN1 sodium solute GH983_17400 ENOG4105D7T ABC transporter GH983_17405 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component GH983_17410 ENOG4107TTD cytosine deaminase GH983_17420 ENOG4105DYS nad(p)h dehydrogenase (quinone) GH983_17425 ENOG4105KME endoribonuclease L-psp GH983_17470 ENOG4105CEY Amp-dependent synthetase and ligase GH983_17485 ENOG4105ETE Transcriptional regulator (LacI family GH983_17500 ENOG4105CK5 oxidoreductase GH983_17525 ENOG4108JQ7 (ABC) transporter GH983_17535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH983_17540 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_17550 ENOG4105C7W Xanthine dehydrogenase GH983_17555 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding GH983_17560 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit GH983_17575 ENOG4105E0A ABC, transporter GH983_17580 ENOG4105WH1 Two component transcriptional regulator luxr family GH983_17620 ENOG4105CQ0 ABC transporter GH983_17625 ENOG4105D05 Receptor GH983_17630 ENOG4108IPW abc transporter atp-binding protein GH983_17635 ENOG4105BZU Histidine kinase GH983_17660 ENOG4105BZU Histidine kinase GH983_17665 ENOG4105RAK Histidine kinase GH983_17670 ENOG4105CQZ Histidine kinase GH983_17680 ENOG4108Z9Z response to DNA damage stimulus GH983_17690 ENOG4108JQ6 ABC transporter GH983_17700 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_17710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_17725 ENOG4105C2J ABC transporter GH983_17735 ENOG4105CNN ABC, transporter GH983_17745 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GH983_17750 ENOG4105DKQ ROK family GH983_17755 ENOG41069M3 Transcriptional regulator GH983_17760 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) GH983_17780 ENOG41069H0 dihydroorotase EC 3.5.2.3 GH983_17805 ENOG4107QXX ABC transporter GH983_17810 ENOG4108JPW Aminotransferase GH983_17815 ENOG4105EW9 transcriptional regulator AsnC family GH983_17885 ENOG4105E4C Lytic transglycosylase catalytic GH983_17890 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GH983_17900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GH983_17905 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GH983_17910 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GH983_17915 ENOG4105CFH Aspartokinase GH983_17920 ENOG4105FF5 Membrane GH983_17930 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GH983_17950 ENOG4105VW4 glutaredoxin 3 GH983_17960 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH983_17975 ENOG4105M6F mutator MutT protein GH983_17980 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GH983_17985 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) GH983_17990 ENOG4105EIN peptidylprolyl cis-trans isomerase GH983_17995 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GH983_18030 ENOG4108UM1 dedA family GH983_18050 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GH983_18060 ENOG4105E1F short-chain dehydrogenase reductase GH983_18070 ENOG4108WBT adenosyltransferase GH983_18080 ENOG4105BZJ Electron transfer flavoprotein GH983_18085 ENOG4105C10 Electron transfer flavoprotein GH983_18090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GH983_18095 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GH983_18100 ENOG4108I5D sulfate abc transporter GH983_18105 ENOG4105ECW sulfate abc transporter GH983_18110 ENOG4108IJ6 ABC transporter GH983_18115 ENOG4105BZU Histidine kinase GH983_18120 ENOG4107ZT5 Thiol disulfide interchange protein GH983_18125 ENOG4105CH7 arginosuccinase GH983_18135 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GH983_18150 ENOG4108UGV hypoxanthine phosphoribosyltransferase GH983_18160 ENOG4105CAK Cell division ATP-binding protein ftsE GH983_18180 ENOG4108NH8 Cation transport protein GH983_18195 ENOG4105CIH Imidazole acetol-phosphate transaminase GH983_18200 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GH983_18205 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GH983_18230 ENOG4105KDC 50s ribosomal protein l28 GH983_18235 ENOG4105EX9 Membrane GH983_18265 ENOG4108JU6 CBS domain protein GH983_18270 ENOG4105D49 3-dehydroquinate synthase GH983_18275 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GH983_18280 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH983_18285 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GH983_18290 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GH983_18295 ENOG4105VFE sira family GH983_18300 ENOG4105CKI cobalamin synthesis protein GH983_18305 ENOG4105DZ1 carboxypeptidase GH983_18355 ENOG4108Z9Z response to DNA damage stimulus GH983_18370 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GH983_18375 ENOG4105XDF Protein of unknown function (DUF1272) GH983_18385 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GH983_18410 ENOG4105CFU surface antigen GH983_18430 ENOG4107SDU Methyl-accepting chemotaxis GH983_18435 ENOG4108V3W Chemotaxis protein, CheW GH983_18440 ENOG4105HDK L-asparaginase GH983_18450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GH983_18455 ENOG4108IEG Formate dehydrogenase Alpha subunit GH983_18460 ENOG4107QIZ NADH dehydrogenase GH983_18480 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GH983_18485 ENOG4105ETT transcriptional Regulator, LysR family GH983_18490 ENOG4105C26 Dehydrogenase GH983_18495 ENOG4105CXK mandelate racemase muconate lactonizing GH983_18500 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GH983_18505 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GH983_18510 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GH983_18515 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GH983_18520 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GH983_18525 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GH983_18535 ENOG4105C25 Primosomal protein n' GH983_18545 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH983_18565 ENOG4107QN2 dihydrolipoyl dehydrogenase GH983_18570 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GH983_18585 ENOG4105C7S Dehydrogenase GH983_18595 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GH983_18600 ENOG4105CMV Succinyl-CoA synthetase subunit beta GH983_18605 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GH983_18610 ENOG4105D6Z AFG1 family ATPase GH983_18615 ENOG4105YU5 Outer membrane lipoprotein GH983_18620 ENOG4105E33 succinate dehydrogenase GH983_18625 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GH983_18635 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) GH983_18645 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GH983_18660 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GH983_18665 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GH983_18670 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GH983_18695 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GH983_18710 ENOG410856B UPF0235 protein GH983_18715 ENOG4105F0N pyrophosphate phospho-hydrolase GH983_18735 ENOG4105DGW oligopeptidase A GH983_18745 ENOG4105C2C drug resistance transporter, Bcr CflA GH983_18750 ENOG4105CDH Citrulline--aspartate ligase GH983_18755 ENOG4105VV5 Plasmid stabilization system GH983_18760 ENOG4105X54 addiction module antidote protein GH983_18775 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GH983_18790 ENOG4105KZX Pterin carbinolamine dehydratase GH983_18795 ENOG4105KJF protein tyrosine phosphatase GH983_18800 ENOG4105M7V 2'-5' rna ligase GH983_18810 ENOG4108I0Y (ABC) transporter GH983_18820 ENOG4105HFZ Membrane GH983_18825 ENOG4108VJ1 Transcriptional regulator (CarD family GH983_18830 ENOG4108Z4U Ferredoxin GH983_18865 ENOG4105CHR reductase GH983_18875 ENOG4108NVM synthesis repressor PhaR GH983_18885 ENOG41082R8 50S ribosomal protein l32 GH983_18895 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GH983_18900 ENOG4105CTB Polyprenyl synthetase GH983_18905 ENOG4105CIH Imidazole acetol-phosphate transaminase GH983_18915 ENOG4108ZG0 Ompa motb domain protein GH983_18920 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GH983_18925 ENOG4106UW1 Major Facilitator superfamily GH983_18930 ENOG4105DJP Membrane GH983_18935 ENOG4105CH2 amidohydrolase GH983_18940 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GH983_18945 ENOG4105E2V Glycosyltransferase 36 GH983_18950 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GH983_18960 ENOG4105BZ1 (ABC) transporter GH983_18965 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GH983_18980 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GH983_18990 ENOG4108IJ9 (ABC) transporter GH983_19000 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GH983_19020 ENOG4107QZW Altronate oxidoreductase GH983_19025 ENOG410617M Transcriptional regulator GH983_19030 ENOG4105CTX dehydratase GH983_19045 ENOG4105D4B ABC, transporter GH983_19050 ENOG4105C2J ABC transporter GH983_19055 ENOG4105CNN ABC, transporter GH983_19060 ENOG4105CPQ Dehydrogenase GH983_19065 ENOG4105FBA Phospholipase Carboxylesterase GH983_19070 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GH983_19075 ENOG4105JQN Transcriptional regulator GH983_19080 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GH983_19125 ENOG4105ENV phosphonate C-P lyase system protein PhnK GH983_19130 ENOG4105HRV phosphonate c-p lyase system protein phnl GH983_19140 ENOG4105D5T phosphonate abc transporter GH983_19145 ENOG4106AFQ Histidine kinase GH983_19150 ENOG4105S7S phosphonate abc transporter GH983_19160 ENOG4108TXN phosphonate metabolism protein GH983_19165 ENOG4105FD8 phosphonate metabolism protein PhnM GH983_19170 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GH983_19180 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GH983_19185 ENOG4105K46 50S ribosomal protein l27 GH983_19205 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GH983_19210 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GH983_19215 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GH983_19220 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GH983_19230 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GH983_19240 ENOG4105CN1 protease GH983_19250 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GH983_19255 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GH983_19275 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA GH983_19280 ENOG4105C0B DNA polymerase III (alpha subunit) GH983_19310 ENOG4105C5H ABC transporter GH983_19330 ENOG4107T0D ABC, transporter GH983_19335 ENOG4105ERG peptidase m48, ste24p GH983_19350 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH983_19355 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GH983_19360 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GH983_19365 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GH983_19385 ENOG4105CVG Homoserine O-transsuccinylase GH983_19410 ENOG4105K63 Thioredoxin GH983_19420 ENOG4105W49 UPF0434 protein GH983_19430 ENOG4105C29 acyl-CoA thioesterase GH983_19435 ENOG4108YZA Nitrogen regulatory protein pii GH983_19440 ENOG4105BZU Histidine kinase GH983_19445 ENOG4105CNU cell division protein FtsK GH983_19450 ENOG4107TMZ Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GH983_19465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH983_19485 ENOG4107R0W ABC transporter GH983_19490 ENOG4105E5Q amino acid AbC transporter GH983_19495 ENOG4108JMC lipopolysaccharide core biosynthesis protein GH983_19500 ENOG4105CSR polyphosphate kinase 2 GH983_19510 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GH983_19520 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GH983_19530 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GH983_19535 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GH983_19540 ENOG4105K5M 30s ribosomal protein S16 GH983_19545 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GH983_19550 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GH983_19560 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GH983_19575 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GH983_19585 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GH983_19590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GH983_19595 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GH983_19600 ENOG4107835 probably involved in intracellular septation (By similarity) GH983_19605 ENOG4108VRQ UPF0314 protein GH983_19620 ENOG41060IM Heme exporter protein GH983_19625 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GH983_19630 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GH983_19635 ENOG4107QM5 aconitate hydratase GH983_19645 ENOG4108RTU Aldolase GH983_19650 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 GH983_19675 ENOG4108HWW ABC transporter GH983_19685 ENOG4105DFW ABC transporter GH983_19705 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GH983_19715 ENOG4107B2H carbonic anhydrase GH983_19725 ENOG4105C7I Dehydrogenase GH983_19730 ENOG4105DEU major facilitator superfamily GH983_19735 ENOG4105DC1 bifunctional purine biosynthesis protein purh GH983_19745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GH983_19750 ENOG4105D0M Protease HtpX homolog GH983_19765 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH983_19775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH983_19780 ENOG4105DFA alanine racemase domain protein GH983_19785 ENOG4105C8T Leucyl-tRNA synthetase GH983_19800 ENOG4105FA0 parb-like partition protein GH983_19805 ENOG4107QJE Chromosome Partitioning Protein GH983_19810 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) GH983_19815 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GH983_19820 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GH983_19825 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GH983_19830 ENOG4108YXA Membrane GH983_19835 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GH983_19840 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GH983_19845 ENOG4108UHJ MAF-like protein GH983_19850 ENOG4105E2X shikimate dehydrogenase GH983_19855 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GH983_19860 ENOG4108JDX DNA polymerase iii, epsilon subunit GH983_19865 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GH983_19895 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH983_19920 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GH983_19925 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GH983_19930 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GH983_19935 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GH983_19950 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GH983_19960 ENOG4108S0S Nucleotidyl transferase GH983_19965 ENOG4105EHM Aminoglycoside phosphotransferase GH983_19970 ENOG4105I8F Histidine kinase GH983_19975 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) GH983_19980 ENOG41080Z8 PHOSPHOCARRIER protein GH983_19985 ENOG4108EQA pts system GH983_19995 ENOG4105EB3 Histidine kinase GH983_20000 ENOG4105E3W Two component transcriptional regulator (Winged helix family GH983_20005 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GH983_20010 ENOG4108YZN class I peptide chain release factor GH983_20015 ENOG4105CF1 Alkylated DNA repair protein GH983_20020 ENOG4105CS9 pantothenic acid kinase GH983_20025 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase GH983_20030 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GH983_20035 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GH983_20040 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GH983_20045 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GH983_20050 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GH983_20055 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GH983_20075 ENOG4107QP3 malate synthase g GH983_20080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH983_20090 ENOG4108UYB regulatoR GH983_20095 ENOG4105TX3 Histidine kinase GH983_20100 ENOG4105CQ7 ATP-dependent helicase GH983_20105 ENOG4105CIF Ornithine Cyclodeaminase GH983_20145 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GH983_20150 ENOG4105ZXK Dehydrogenase GH983_20155 ENOG4105CNN ABC, transporter GH983_20165 ENOG4105C2J ABC transporter GH983_20175 ENOG4105DIQ Transcriptional regulator GH983_20180 ENOG4105G63 Type III effector Hrp-dependent GH983_20190 ENOG4105DEI Mannitol dehydrogenase GH983_20195 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GH983_20200 ENOG4105CPQ Dehydrogenase GH983_20205 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_20215 ENOG4108ERU trap dicarboxylate transporter subunit DctP GH983_20220 ENOG4107YCY Transcriptional regulator GH983_20230 ENOG41073TP transcriptional regulator GH983_20235 ENOG4105C0A alcohol dehydrogenase GH983_20255 ENOG4105DEF Extracellular solute-binding protein, family 5 GH983_20260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH983_20265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH983_20270 ENOG4108JQ6 ABC transporter GH983_20275 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH983_20285 ENOG4105C5X domain protein GH983_20290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_20300 ENOG4105F38 ABC transporter, permease GH983_20310 ENOG410630P Transcriptional regulator GH983_20320 ENOG4105CSH Transporter GH983_20325 ENOG4105E2S oxidase) subunit II GH983_20330 ENOG4105BZ9 Cytochrome C oxidase, subunit I GH983_20335 ENOG4105CCU oxidase (Subunit III) GH983_20340 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GH983_20360 ENOG4105ENT Efflux transporter rnd family, mfp subunit GH983_20370 ENOG4105CZE histidine utilization repressor GH983_20375 ENOG41090B9 response to stress GH983_20380 ENOG4105CGP Urocanate hydratase GH983_20390 ENOG4105C84 Histidine ammonia-lyase GH983_20395 ENOG4105CI2 imidazolone-5-propionate hydrolase GH983_20400 ENOG4105C84 Histidine ammonia-lyase GH983_20405 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GH983_20410 ENOG4105EF1 ribulokinase GH983_20415 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GH983_20420 ENOG4105DEI Mannitol dehydrogenase GH983_20425 ENOG4105CHR reductase GH983_20430 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_20450 ENOG4105DKT Transcriptional regulator GH983_20475 ENOG4105CEP NADH dehydrogenase GH983_20480 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GH983_20490 ENOG4105EHG Permease protein GH983_20495 ENOG4105E98 transcriptional regulator DeoR family GH983_20500 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GH983_20505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_20510 ENOG4108IJ9 (ABC) transporter GH983_20520 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component GH983_20540 ENOG4107T0X DNA ligase GH983_20555 ENOG4108NIX Factor ChrR GH983_20560 ENOG4105K6V RNA polymerase GH983_20575 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GH983_20580 ENOG4105EMU Dehydrogenase GH983_20595 ENOG4107U9H DNA polymerase GH983_20620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GH983_20625 ENOG4105CAT Cytidine monophosphate kinase GH983_20660 ENOG4105EN6 Membrane GH983_20670 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GH983_20680 ENOG4108WQH regulatoR GH983_20695 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GH983_20700 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GH983_20705 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GH983_20710 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GH983_20715 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GH983_20725 ENOG4105CHV Transcription elongation factor NusA GH983_20730 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GH983_20735 ENOG4107SFI Major Facilitator superfamily GH983_20745 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GH983_20760 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GH983_20765 ENOG4107QMP dna polymerase iii subunits gamma and tau GH983_20780 ENOG4105E09 nadh pyrophosphatase GH983_20785 ENOG4105CQC Prephenate dehydratase GH983_20790 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GH983_20795 ENOG4105G9V cytochrome C GH983_20830 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GH983_20840 ENOG41069P5 Protein slyX homolog GH983_20855 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GH983_20865 ENOG4105CFG Acts as a chaperone (By similarity) GH983_20870 ENOG4108JQC penicillin-binding protein 1A GH983_20875 ENOG4108UIN ybak prolyl-trna synthetase associated region GH983_20890 ENOG4105C2M dna polymerase I GH983_20900 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GH983_20905 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GH983_20915 ENOG4105CHC glucokinase (EC 2.7.1.2) GH983_20920 ENOG4108Z5K methylglyoxal synthase GH983_20925 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GH983_20935 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GH983_20940 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GH983_20955 ENOG4108JQ5 ABC transporter GH983_20970 ENOG4107RH7 Nicotinate phosphoribosyltransferase GH983_21040 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GH983_21045 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GH983_21050 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GH983_21060 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GH983_21065 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GH983_21090 ENOG4108JQ9 ABC transporter GH983_21095 ENOG4105DIH basic membrane GH983_21100 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GH983_21120 ENOG4108W9H Tetr family transcriptional regulator GH983_21125 ENOG4107S9B Shikimate dehydrogenase GH983_21130 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GH983_21140 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GH983_21150 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_21155 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH983_21165 ENOG4105C9B Cysteine desulfurase GH983_21170 ENOG4105CDA abc transporter atp-binding protein GH983_21175 ENOG4105E5Q amino acid AbC transporter GH983_21180 ENOG4106PMH Extracellular solute-binding protein family 3 GH983_21185 ENOG41073TP transcriptional regulator GH983_21190 ENOG4105DER m42 family GH983_21215 ENOG4105CAQ asparagine synthetase GH983_21220 ENOG4105D9M gamma-glutamylcysteine synthetase GH983_21235 ENOG4108N8X transition metal ion binding GH983_21260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GH983_21270 ENOG4107SN7 NLP P60 protein GH983_21385 ENOG4106YAV Domain of unknown function (DUF1508) GH983_21400 ENOG4105KVH Transcriptional regulator GH983_21405 ENOG4105ECR NmrA family GH983_21410 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GH983_21435 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain GH983_21445 ENOG4105CPQ Dehydrogenase GH983_21450 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GH983_21485 ENOG4105CH5 extracellular solute-binding protein, family 7 GH983_21510 ENOG4105DCM major facilitator superfamily GH983_21525 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GH983_21540 ENOG4105XJC Two component transcriptional regulator (Winged helix family GH983_21545 ENOG4105EB3 Histidine kinase GH983_21550 ENOG41082BR 50S ribosomal protein L35 GH983_21555 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GH983_21560 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GH983_21580 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GH983_21585 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GH983_21610 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GH983_21615 ENOG4105T38 integral membrane protein GH983_21620 ENOG4107SET aldo keto reductase GH983_21625 ENOG4105CPC Aldo Keto reductase GH983_21650 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) GH983_21655 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH983_21660 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 GH983_21670 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GH983_21675 ENOG4108X0B nad(p)h dehydrogenase (quinone) GH983_21705 ENOG4105C88 aminopeptidase GH983_21710 ENOG4108Z66 YbaK ebsC protein GH983_21715 ENOG4105KUZ arsenate reductase GH983_21725 ENOG4108ETT Dehydrogenase GH983_21735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GH983_21750 ENOG4105KAV tspo and mbr like protein GH983_21775 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GH983_21780 ENOG4105K6T rare lipoprotein A GH983_21790 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GH983_21800 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GH983_21815 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GH983_21825 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GH983_21830 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GH983_21835 ENOG41082FP UPF0102 protein GH983_21855 ENOG4108IJ9 (ABC) transporter GH983_21860 ENOG4105D7Z glutathione synthase GH983_21865 ENOG4105C0P Mg chelatase subunit ChlI GH983_21870 ENOG410903D sensor protein GH983_21885 ENOG4105N14 lysine exporter protein LysE YggA GH983_21900 ENOG4108YXU transcriptional regulator AsnC family GH983_21910 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GH983_21915 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GH983_21925 ENOG4105DWF phosphomethylpyrimidine kinase GH983_21935 ENOG4105EUB pirin domain protein GH983_21950 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GH983_21955 ENOG4105RAK Histidine kinase GH983_21960 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GH983_21965 ENOG4105BZU Histidine kinase GH983_21970 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GH983_21975 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GH983_21980 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GH983_21985 ENOG4105E39 Enoyl-CoA hydratase GH983_21990 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GH983_22030 ENOG4105BZU Histidine kinase GH983_22035 ENOG4107Z5C methylesterase GH983_22040 ENOG4105BZU Histidine kinase GH983_22045 ENOG4105BZU Histidine kinase GH983_22060 ENOG4108302 MgtC SapB transporter GH983_22185 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GH983_22215 ENOG4107SCK Monooxygenase GH983_22225 ENOG4105C2C drug resistance transporter, Bcr CflA GH983_22270 ENOG4108IG5 Transcriptional regulator GH983_22285 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GH983_22290 ENOG4105KCV RNA signal recognition particle 4.5S RNA GH983_22295 ENOG4105CH2 amidohydrolase GH983_22315 ENOG4105CH2 amidohydrolase GH983_22320 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GH983_22375 ENOG4105FA0 parb-like partition protein GH983_22565 ENOG4105C8Q Methyl-accepting chemotaxis GH983_22575 ENOG41080HT Transcriptional regulator, arsr family GH983_22580 ENOG4105WAB arsR family transcriptional regulator GH983_22585 ENOG4105VEQ Cold shock protein GH983_22600 ENOG4105C8Q Methyl-accepting chemotaxis GH983_22605 ENOG4105BZU Histidine kinase GH983_22610 ENOG4105CVJ phosphoglycerate mutase GH983_22635 ENOG4108302 MgtC SapB transporter GH983_22645 ENOG4105K64 Glycosyl transferase, family 2 GH983_22665 ENOG4107RSM transcriptional regulator GH983_22680 ENOG4105F38 ABC transporter, permease GH983_22685 ENOG4108I5D sulfate abc transporter GH983_22690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_22730 ENOG4107R11 Transcriptional regulator GH983_22740 ENOG4105UIB (ABC) transporter GH983_22755 ENOG4108JQ9 ABC transporter GH983_22760 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) GH983_22815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH983_22820 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH983_22915 ENOG4105C8Q Methyl-accepting chemotaxis GH983_22960 ENOG4107SDU Methyl-accepting chemotaxis GH983_22965 ENOG4105BZU Histidine kinase GH983_22975 ENOG4105BZU Histidine kinase GH983_22980 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit GH983_23000 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GH983_23005 ENOG4105C2J ABC transporter GH983_23025 ENOG4105DKT Transcriptional regulator GH983_23040 ENOG4108JQ9 ABC transporter GH983_23055 ENOG4105DZC cytosine deaminase GH983_23070 ENOG4105DJY efflux transporter, rnd family, mfp subunit GH983_23100 ENOG41080HT Transcriptional regulator, arsr family GH983_23140 ENOG4107R3N Filamentation induced by cAMP protein fic GH983_23145 ENOG4105CC0 LysR family Transcriptional regulator GH983_23155 ENOG4108DEF Globin GH983_23160 ENOG4107S9F NmrA family GH983_23185 ENOG4105BZU Histidine kinase GH983_23210 ENOG4105EMU Dehydrogenase GH983_23215 ENOG4105EQ2 LysR family Transcriptional regulator GH983_23225 ENOG4105CPC Aldo Keto reductase GH983_23235 ENOG4105E7U AraC family transcriptional regulator GH983_23250 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit GH983_23260 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GH983_23265 ENOG4105E9Z Nad-dependent epimerase dehydratase GH983_23280 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region GH983_23285 ENOG4105JSC dimethylmenaquinone methyltransferase GH983_23300 ENOG4105G3Z GntR family transcriptional regulator GH983_23305 ENOG4105C01 Dihydroxy-acid dehydratase GH983_23310 ENOG4105FGE Short-chain dehydrogenase reductase Sdr GH983_23315 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH983_23320 ENOG4105C2J ABC transporter GH983_23325 ENOG4105CNN ABC, transporter GH983_23330 ENOG4105C26 Dehydrogenase GH983_23345 ENOG4106HB6 Alpha beta hydrolase GH983_23370 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GH983_23375 ENOG4105DND Transcriptional regulator GH983_23380 ENOG4105E7W lamb ycsf family protein GH983_23385 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GH983_23390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GH983_23405 ENOG4108SV3 Tmao reductase system periplasmic protein tort GH983_23410 ENOG4105C2J ABC transporter GH983_23415 ENOG4105CNN ABC, transporter GH983_23455 ENOG41067QW Transcriptional regulator GH983_23495 ENOG4105C4R Atp-dependent dna helicase GH983_23505 ENOG4107RSM transcriptional regulator GH983_23550 ENOG4107QQG Dehydrogenase GH983_23560 ENOG4105J5G Transferase hexapeptide repeat containing protein GH983_23565 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GH983_23570 ENOG4105CMR udp-glucose 4-epimerase GH983_23575 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GH983_23580 ENOG4105CAQ asparagine synthetase GH983_23585 ENOG4108JU4 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GH983_23605 ENOG4105BZ1 (ABC) transporter GH983_23610 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GH983_23615 ENOG4108REZ Imidazole glycerol phosphate synthase GH983_23620 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GH983_23650 ENOG4105CAQ asparagine synthetase GH983_23665 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GH983_23685 ENOG4105D3Q Sugar transferase GH983_23695 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GH983_23700 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GH983_23715 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GH983_23730 ENOG4107SET aldo keto reductase GH983_23740 ENOG4105ETE Transcriptional regulator (LacI family GH983_23755 ENOG4105C2J ABC transporter GH983_23760 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GH983_23765 ENOG4105CMT Dihydroxyacetone kinase GH983_23775 ENOG4108HMQ sugar kinase GH983_23785 ENOG4105CXK mandelate racemase muconate lactonizing GH983_23795 ENOG4105C26 Dehydrogenase GH983_23805 ENOG4105BZU Histidine kinase GH983_23810 ENOG4105ETE Transcriptional regulator (LacI family GH983_23825 ENOG4105E0C molybdate abc transporter GH983_23830 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH983_23870 ENOG4108WRK Transcriptional regulator GH983_23875 ENOG4106TD9 Diguanylate cyclase GH983_23955 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GH983_24010 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GH983_24015 ENOG4105D75 Capsular exopolysaccharide family GH983_24020 ENOG4105C6Y Udp-glucose 6-dehydrogenase GH983_24025 ENOG4105C1B dTDP-glucose 4-6-dehydratase GH983_24040 ENOG4107R4N Cell wall formation (By similarity) GH983_24045 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)