locus-tag	class	description
GH983_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH983_00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH983_00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH983_00025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GH983_00030	COG1420	regulation of RNA biosynthetic process
GH983_00035	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GH983_00040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH983_00045	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GH983_00055	COG1137	ATPase activity
GH983_00060	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GH983_00070	COG0776	regulation of translation
GH983_00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH983_00080	COG0116	Belongs to the methyltransferase superfamily
GH983_00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH983_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH983_00105	COG0281	malic enzyme
GH983_00105	COG0280	phosphate acetyltransferase
GH983_00110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GH983_00115	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GH983_00130	COG0346	lactoylglutathione lyase activity
GH983_00135	COG0180	Tryptophanyl-tRNA synthetase
GH983_00145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GH983_00170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH983_00175	COG1702	phosphate starvation-inducible protein PhoH
GH983_00180	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GH983_00190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GH983_00195	COG1396	sequence-specific DNA binding
GH983_00200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GH983_00205	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GH983_00215	COG0071	Belongs to the small heat shock protein (HSP20) family
GH983_00225	COG0840	transmembrane signaling receptor activity
GH983_00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH983_00240	COG0840	transmembrane signaling receptor activity
GH983_00250	COG0242	peptide deformylase activity
GH983_00255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH983_00260	COG0101	tRNA pseudouridine synthase activity
GH983_00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH983_00280	COG2171	N-acyltransferase activity
GH983_00305	COG0477	Major facilitator Superfamily
GH983_00310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GH983_00325	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH983_00330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GH983_00340	COG0706	membrane insertase activity
GH983_00345	COG0594	ribonuclease P activity
GH983_00350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GH983_00355	COG5002	protein histidine kinase activity
GH983_00380	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
GH983_00395	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GH983_00410	COG3938	Belongs to the proline racemase family
GH983_00415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH983_00445	COG0529	Catalyzes the synthesis of activated sulfate
GH983_00470	COG0418	dihydroorotase activity
GH983_00480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GH983_00495	COG0166	Belongs to the GPI family
GH983_00500	COG0318	PFAM AMP-dependent synthetase and ligase
GH983_00530	COG2326	polyphosphate kinase activity
GH983_00535	COG5002	protein histidine kinase activity
GH983_00545	COG0573	inorganic phosphate transmembrane transporter activity
GH983_00550	COG0581	inorganic phosphate transmembrane transporter activity
GH983_00555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH983_00560	COG0704	Plays a role in the regulation of phosphate uptake
GH983_00565	COG0745	RESPONSE REGULATOR receiver
GH983_00575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH983_00580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH983_00585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GH983_00595	COG2967	ApaG domain
GH983_00605	COG0717	Belongs to the dCTP deaminase family
GH983_00665	COG0167	dihydroorotate dehydrogenase activity
GH983_00670	COG0534	Mate efflux family protein
GH983_00695	COG1201	RNA secondary structure unwinding
GH983_00710	COG0730	response to heat
GH983_00720	COG1960	acyl-CoA dehydrogenase activity
GH983_00725	COG0183	Belongs to the thiolase family
GH983_00735	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH983_00735	COG1024	Enoyl-CoA hydratase
GH983_00740	COG0584	glycerophosphoryl diester phosphodiesterase
GH983_00755	COG2205	protein histidine kinase activity
GH983_00755	COG2198	Histidine kinase
GH983_00755	COG0784	Response regulator, receiver
GH983_00760	COG1970	mechanosensitive ion channel activity
GH983_00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_00780	COG1129	ABC transporter
GH983_00780	COG0842	Transport permease protein
GH983_00785	COG0842	Transport permease protein
GH983_00790	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GH983_00815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GH983_00825	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GH983_00830	COG5328	Belongs to the UPF0262 family
GH983_00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GH983_00845	COG0424	maF-like protein
GH983_00850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GH983_00875	COG0747	negative chemotaxis
GH983_00880	COG0601	transmembrane transport
GH983_00885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_00890	COG0444	Belongs to the ABC transporter superfamily
GH983_00895	COG4608	Belongs to the ABC transporter superfamily
GH983_00905	COG1448	Aminotransferase
GH983_00915	COG1120	ATPase activity
GH983_00920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_00930	COG2226	methyltransferase
GH983_00940	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_00945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH983_00960	COG1733	regulation of RNA biosynthetic process
GH983_00980	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_00985	COG1129	ABC transporter
GH983_00990	COG1879	ABC-type sugar transport system periplasmic component
GH983_00995	COG4585	Histidine kinase
GH983_01005	COG2137	regulation of response to DNA damage stimulus
GH983_01015	COG2423	ornithine cyclodeaminase activity
GH983_01030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_01035	COG3618	amidohydrolase
GH983_01040	COG4948	Mandelate Racemase Muconate Lactonizing
GH983_01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_01050	COG2186	Transcriptional regulator
GH983_01055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_01070	COG2274	protein secretion by the type I secretion system
GH983_01100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH983_01125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH983_01160	COG1012	belongs to the aldehyde dehydrogenase family
GH983_01175	COG1024	Enoyl-CoA hydratase
GH983_01185	COG4770	biotin carboxylase activity
GH983_01190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GH983_01195	COG4336	lyase activity
GH983_01200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GH983_01205	COG1914	H( )-stimulated, divalent metal cation uptake system
GH983_01210	COG1802	Transcriptional regulator
GH983_01215	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_01220	COG1607	acyl-coa hydrolase
GH983_01270	COG0297	glycogen (starch) synthase activity
GH983_01280	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GH983_01295	COG0840	transmembrane signaling receptor activity
GH983_01310	COG0643	Histidine kinase
GH983_01310	COG2198	Histidine kinase
GH983_01315	COG0835	chemotaxis
GH983_01320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH983_01325	COG2201	protein-glutamate methylesterase activity
GH983_01330	COG0745	RESPONSE REGULATOR receiver
GH983_01335	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GH983_01345	COG1766	The M ring may be actively involved in energy transduction
GH983_01350	COG2771	luxR family
GH983_01365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH983_01370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH983_01375	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH983_01380	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH983_01385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH983_01390	COG4786	Flagellar basal body rod
GH983_01395	COG1157	protein secretion by the type III secretion system
GH983_01405	COG1815	bacterial-type flagellum-dependent cell motility
GH983_01410	COG1558	bacterial-type flagellum-dependent cell motility
GH983_01415	COG1677	Flagellar hook-basal body complex protein FliE
GH983_01420	COG4786	Flagellar basal body rod
GH983_01425	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GH983_01430	COG1706	bacterial-type flagellum-dependent cell motility
GH983_01440	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GH983_01450	COG1338	Plays a role in the flagellum-specific transport system
GH983_01465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH983_01470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH983_01480	COG1360	Flagellar Motor Protein
GH983_01505	COG1749	Flagellar hook protein flgE
GH983_01510	COG1256	bacterial-type flagellum assembly
GH983_01510	COG4786	Flagellar basal body rod
GH983_01525	COG5443	negative regulation of bacterial-type flagellum assembly
GH983_01530	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH983_01535	COG4794	Type iii secretion
GH983_01540	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH983_01575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GH983_01580	COG1609	Transcriptional regulator
GH983_01585	COG1653	transport
GH983_01590	COG1175	transmembrane transport
GH983_01595	COG0395	ABC-type sugar transport system, permease component
GH983_01600	COG0366	Alpha amylase catalytic
GH983_01605	COG3842	ATPase activity
GH983_01615	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_01630	COG1595	DNA-templated transcription, initiation
GH983_01645	COG0129	dihydroxy-acid dehydratase activity
GH983_01650	COG0363	glucosamine-6-phosphate deaminase activity
GH983_01655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH983_01660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_01670	COG2081	HI0933 family
GH983_01680	COG0840	transmembrane signaling receptor activity
GH983_01680	COG2972	Histidine kinase
GH983_01700	COG2224	Isocitrate lyase
GH983_01710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GH983_01715	COG3842	ATPase activity
GH983_01720	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_01725	COG1177	transmembrane transport
GH983_01740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH983_01745	COG1178	ABC-type Fe3 transport system permease component
GH983_01755	COG2205	protein histidine kinase activity
GH983_01780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH983_01805	COG4269	membrane
GH983_01810	COG4783	chaperone-mediated protein folding
GH983_01815	COG1840	ABC-type Fe3 transport system, periplasmic component
GH983_01820	COG1959	2 iron, 2 sulfur cluster binding
GH983_01830	COG3265	gluconokinase activity
GH983_01840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_01845	COG0174	glutamine synthetase
GH983_01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_01855	COG2832	Protein of unknown function (DUF454)
GH983_01860	COG5001	Diguanylate cyclase
GH983_01880	COG1120	ATPase activity
GH983_01885	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_01895	COG4592	Periplasmic binding protein
GH983_01900	COG4774	siderophore transport
GH983_01915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH983_01930	COG1609	Transcriptional regulator
GH983_01940	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_01945	COG3833	ABC-type maltose transport systems, permease component
GH983_01950	COG3842	ATPase activity
GH983_01960	COG0483	inositol monophosphate 1-phosphatase activity
GH983_01965	COG3842	ATPase activity
GH983_01970	COG0395	ABC-type sugar transport system, permease component
GH983_01975	COG1175	transmembrane transport
GH983_01980	COG1653	transport
GH983_02000	COG1006	Multisubunit Na H antiporter MnhC subunit
GH983_02005	COG0651	ATP synthesis coupled electron transport
GH983_02010	COG1863	multisubunit Na H antiporter MnhE subunit
GH983_02015	COG2212	antiporter activity
GH983_02020	COG1320	monovalent cation:proton antiporter activity
GH983_02040	COG4771	TonB-dependent receptor
GH983_02045	COG2204	response regulator
GH983_02050	COG4191	Histidine kinase
GH983_02055	COG1320	monovalent cation:proton antiporter activity
GH983_02075	COG1006	Multisubunit Na H antiporter MnhC subunit
GH983_02120	COG0438	transferase activity, transferring glycosyl groups
GH983_02135	COG4191	Histidine kinase
GH983_02135	COG0784	Response regulator, receiver
GH983_02150	COG1278	Cold shock
GH983_02155	COG0659	secondary active sulfate transmembrane transporter activity
GH983_02160	COG0589	response to stress
GH983_02200	COG1129	ABC transporter
GH983_02205	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_02210	COG2390	Transcriptional regulator
GH983_02215	COG0667	Aldo Keto reductase
GH983_02220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GH983_02225	COG1830	Aldolase
GH983_02230	COG1070	Carbohydrate kinase
GH983_02250	COG1309	transcriptional regulator
GH983_02255	COG1595	DNA-templated transcription, initiation
GH983_02270	COG0662	Cupin 2, conserved barrel domain protein
GH983_02320	COG1136	(ABC) transporter
GH983_02325	COG3707	response regulator
GH983_02330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH983_02335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH983_02340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_02345	COG1116	anion transmembrane transporter activity
GH983_02350	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH983_02360	COG0243	molybdopterin cofactor binding
GH983_02365	COG1648	precorrin-2 dehydrogenase activity
GH983_02365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH983_02375	COG0745	RESPONSE REGULATOR receiver
GH983_02380	COG1840	ABC-type Fe3 transport system, periplasmic component
GH983_02385	COG1840	ABC-type Fe3 transport system, periplasmic component
GH983_02395	COG3842	ATPase activity
GH983_02405	COG0668	transmembrane transport
GH983_02415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH983_02420	COG1253	flavin adenine dinucleotide binding
GH983_02430	COG0745	RESPONSE REGULATOR receiver
GH983_02435	COG2205	protein histidine kinase activity
GH983_02490	COG2814	Major facilitator Superfamily
GH983_02495	COG2828	Protein conserved in bacteria
GH983_02515	COG0642	Histidine kinase
GH983_02520	COG3639	organic phosphonate transmembrane transporter activity
GH983_02525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GH983_02535	COG3454	Phosphonate metabolism
GH983_02540	COG2188	Transcriptional regulator
GH983_02550	COG0745	RESPONSE REGULATOR receiver
GH983_02565	COG2194	sulfuric ester hydrolase activity
GH983_02590	COG3590	peptidase
GH983_02605	COG0583	DNA-binding transcription factor activity
GH983_02650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_02655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH983_02670	COG0248	Ppx GppA phosphatase
GH983_02675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GH983_02685	COG0477	Major facilitator Superfamily
GH983_02715	COG0412	Dienelactone hydrolase
GH983_02740	COG0583	DNA-binding transcription factor activity
GH983_02750	COG0840	transmembrane signaling receptor activity
GH983_02770	COG0306	phosphate transporter
GH983_02780	COG0561	phosphatase activity
GH983_02785	COG0438	transferase activity, transferring glycosyl groups
GH983_02795	COG1139	Iron-sulfur cluster binding protein
GH983_02800	COG0247	lactate metabolic process
GH983_02820	COG0583	DNA-binding transcription factor activity
GH983_02825	COG0277	FAD linked oxidase domain protein
GH983_02830	COG0277	FAD linked oxidase domain protein
GH983_02840	COG0247	lactate metabolic process
GH983_02850	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_02855	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_02860	COG2818	Glycosylase
GH983_02895	COG0124	histidyl-tRNA synthetase
GH983_02900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GH983_02905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH983_02910	COG4106	trans-aconitate 2-methyltransferase activity
GH983_02915	COG2259	Doxx family
GH983_02920	COG0625	glutathione transferase activity
GH983_02930	COG0459	protein refolding
GH983_02935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GH983_02950	COG0196	riboflavin kinase activity
GH983_02980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GH983_02990	COG0456	acetyltransferase
GH983_03000	COG0590	tRNA wobble adenosine to inosine editing
GH983_03005	COG1187	pseudouridine synthase activity
GH983_03010	COG0742	ribosomal rna small subunit methyltransferase
GH983_03015	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH983_03025	COG0312	modulator of DNA gyrase
GH983_03040	COG1519	Transferase
GH983_03050	COG1663	tetraacyldisaccharide 4'-kinase activity
GH983_03060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GH983_03065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_03065	COG2205	protein histidine kinase activity
GH983_03070	COG5001	Diguanylate cyclase
GH983_03070	COG3300	MHYT domain
GH983_03075	COG0583	DNA-binding transcription factor activity
GH983_03080	COG5598	trimethylamine methyltransferase
GH983_03085	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH983_03085	COG1902	pentaerythritol trinitrate reductase activity
GH983_03095	COG3386	PFAM SMP-30 Gluconolaconase
GH983_03100	COG2197	response regulator
GH983_03105	COG0489	protein tyrosine kinase activity
GH983_03110	COG0598	Magnesium transport protein CorA
GH983_03115	COG3158	transport of potassium into the cell
GH983_03135	COG0356	it plays a direct role in the translocation of protons across the membrane
GH983_03145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH983_03150	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH983_03155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GH983_03170	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH983_03175	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GH983_03185	COG0142	geranyltranstransferase activity
GH983_03210	COG3920	Histidine kinase
GH983_03210	COG2202	Pas domain
GH983_03215	COG0752	glycyl-tRNA synthetase alpha subunit
GH983_03225	COG2205	protein histidine kinase activity
GH983_03225	COG2202	Pas domain
GH983_03230	COG1704	LemA family
GH983_03235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GH983_03245	COG0751	glycine-tRNA ligase activity
GH983_03250	COG3609	addiction module antidote protein, CC2985 family
GH983_03260	COG1683	Conserved Protein
GH983_03265	COG0840	transmembrane signaling receptor activity
GH983_03275	COG0151	Belongs to the GarS family
GH983_03280	COG2183	response to ionizing radiation
GH983_03295	COG2514	catechol 2,3-dioxygenase activity
GH983_03310	COG3909	cytochrome
GH983_03315	COG2010	Cytochrome c
GH983_03345	COG0789	Transcriptional regulator
GH983_03365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH983_03370	COG3713	MltA-interacting MipA family protein
GH983_03390	COG0725	ABC transporter, periplasmic molybdate-binding protein
GH983_03395	COG4149	molybdate abc transporter
GH983_03400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GH983_03405	COG2005	Transcriptional regulator
GH983_03405	COG3585	molybdate ion transport
GH983_03415	COG0009	L-threonylcarbamoyladenylate synthase
GH983_03430	COG4638	Rieske (2fe-2S)
GH983_03450	COG0850	regulation of cytokinetic process
GH983_03455	COG2894	cell division
GH983_03460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GH983_03470	COG1960	acyl-CoA dehydrogenase activity
GH983_03495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GH983_03515	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH983_03520	COG1722	exodeoxyribonuclease VII activity
GH983_03530	COG2040	homocysteine
GH983_03545	COG4215	(ABC) transporter
GH983_03560	COG1522	sequence-specific DNA binding
GH983_03585	COG2610	gluconate transmembrane transporter activity
GH983_03590	COG1741	Belongs to the pirin family
GH983_03595	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GH983_03615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GH983_03640	COG1268	BioY protein
GH983_03645	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GH983_03650	COG1122	ATPase activity
GH983_03655	COG3214	Protein conserved in bacteria
GH983_03675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH983_03675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH983_03680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GH983_03700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH983_03705	COG0484	heat shock protein binding
GH983_03715	COG0259	pyridoxamine-phosphate oxidase activity
GH983_03725	COG0477	Major facilitator Superfamily
GH983_03730	COG0789	Transcriptional regulator
GH983_03735	COG1686	Belongs to the peptidase S11 family
GH983_03750	COG0312	modulator of DNA gyrase
GH983_03765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH983_03770	COG0109	protoheme IX farnesyltransferase activity
GH983_03780	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GH983_03795	COG3346	SURF1 family
GH983_03805	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GH983_03815	COG3300	MHYT domain
GH983_03815	COG5001	Diguanylate cyclase
GH983_03820	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GH983_03825	COG0328	RNA-DNA hybrid ribonuclease activity
GH983_03835	COG0678	peroxiredoxin activity
GH983_03835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GH983_03845	COG1678	Uncharacterized ACR, COG1678
GH983_03860	COG1280	lysine exporter protein (LysE YggA)
GH983_03865	COG5001	Diguanylate cyclase
GH983_03870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH983_03875	COG0612	Peptidase, M16
GH983_03900	COG1597	lipid kinase activity
GH983_03905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH983_03935	COG3609	addiction module antidote protein, CC2985 family
GH983_03950	COG1268	BioY protein
GH983_03965	COG2070	2-Nitropropane dioxygenase
GH983_03970	COG1942	4-Oxalocrotonate Tautomerase
GH983_03980	COG0625	glutathione transferase activity
GH983_03990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GH983_03995	COG2885	chlorophyll binding
GH983_04005	COG1194	a g-specific adenine glycosylase
GH983_04015	COG0659	secondary active sulfate transmembrane transporter activity
GH983_04020	COG0659	secondary active sulfate transmembrane transporter activity
GH983_04055	COG1196	nuclear chromosome segregation
GH983_04065	COG0738	Major facilitator superfamily
GH983_04075	COG2514	catechol 2,3-dioxygenase activity
GH983_04080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH983_04080	COG0574	Belongs to the PEP-utilizing enzyme family
GH983_04090	COG0574	Belongs to the PEP-utilizing enzyme family
GH983_04090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH983_04105	COG0864	Transcriptional regulator
GH983_04140	COG0693	protein deglycase activity
GH983_04150	COG1132	(ABC) transporter
GH983_04160	COG1215	transferase activity, transferring glycosyl groups
GH983_04170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GH983_04180	COG4604	ABC transporter, ATP-binding protein
GH983_04185	COG4605	iron ion homeostasis
GH983_04190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_04210	COG1595	DNA-templated transcription, initiation
GH983_04240	COG1609	Transcriptional regulator
GH983_04255	COG2895	sulfate adenylyltransferase (ATP) activity
GH983_04260	COG0175	sulfate reduction
GH983_04265	COG0175	sulfate reduction
GH983_04270	COG1959	2 iron, 2 sulfur cluster binding
GH983_04340	COG0392	lysyltransferase activity
GH983_04340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GH983_04355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH983_04360	COG1012	belongs to the aldehyde dehydrogenase family
GH983_04365	COG1309	transcriptional regulator
GH983_04370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GH983_04460	COG0477	Major facilitator Superfamily
GH983_04470	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_04475	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_04495	COG4325	translation initiation factor activity
GH983_04500	COG1846	Transcriptional regulator
GH983_04505	COG1764	response to oxidative stress
GH983_04540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GH983_04545	COG1278	Cold shock
GH983_04560	COG3239	Fatty acid desaturase
GH983_04585	COG1742	UPF0060 membrane protein
GH983_04595	COG0433	COG0433 Predicted ATPase
GH983_04620	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_04650	COG1238	metal cluster binding
GH983_04685	COG1879	ABC-type sugar transport system periplasmic component
GH983_04690	COG4214	carbohydrate transport
GH983_04695	COG1129	ABC transporter
GH983_04715	COG0840	transmembrane signaling receptor activity
GH983_04720	COG3788	relative of glutathione S-transferase, MAPEG superfamily
GH983_04725	COG1272	protein, Hemolysin III
GH983_04745	COG2130	NADP-dependent
GH983_04770	COG0514	ATP-dependent DNA helicase (RecQ)
GH983_04795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH983_04810	COG1006	Multisubunit Na H antiporter MnhC subunit
GH983_04825	COG2212	antiporter activity
GH983_04830	COG1320	monovalent cation:proton antiporter activity
GH983_04835	COG4957	zinc ion binding
GH983_04850	COG2166	iron-sulfur cluster assembly
GH983_04860	COG2205	protein histidine kinase activity
GH983_04960	COG2264	protein methyltransferase activity
GH983_04975	COG3706	GGDEF domain
GH983_04980	COG3706	GGDEF domain
GH983_04985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH983_04990	COG2983	Belongs to the UPF0260 family
GH983_05005	COG0789	Transcriptional regulator
GH983_05015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH983_05020	COG3706	GGDEF domain
GH983_05035	COG2852	Protein conserved in bacteria
GH983_05060	COG4695	Portal protein
GH983_05190	COG0745	RESPONSE REGULATOR receiver
GH983_05195	COG5002	protein histidine kinase activity
GH983_05205	COG4235	cytochrome complex assembly
GH983_05210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH983_05215	COG1138	Cytochrome C-type biogenesis protein
GH983_05220	COG3088	subunit of a heme lyase
GH983_05235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH983_05240	COG0745	RESPONSE REGULATOR receiver
GH983_05245	COG2205	protein histidine kinase activity
GH983_05250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH983_05260	COG2205	protein histidine kinase activity
GH983_05260	COG2202	Pas domain
GH983_05265	COG0308	aminopeptidase N
GH983_05270	COG0840	transmembrane signaling receptor activity
GH983_05270	COG3290	protein histidine kinase activity
GH983_05305	COG0443	Heat shock 70 kDa protein
GH983_05320	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_05330	COG2084	Dehydrogenase
GH983_05340	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_05345	COG1733	regulation of RNA biosynthetic process
GH983_05355	COG1522	sequence-specific DNA binding
GH983_05365	COG2814	Major facilitator Superfamily
GH983_05375	COG4172	Belongs to the ABC transporter superfamily
GH983_05380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_05385	COG0601	transmembrane transport
GH983_05395	COG0174	glutamine synthetase
GH983_05435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GH983_05460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH983_05485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GH983_05495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GH983_05505	COG0741	lytic transglycosylase activity
GH983_05510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_05520	COG2311	Membrane
GH983_05530	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GH983_05545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GH983_05545	COG2169	Transcriptional regulator
GH983_05555	COG1758	RNA polymerase activity
GH983_05575	COG0736	holo-[acyl-carrier-protein] synthase activity
GH983_05580	COG0681	Belongs to the peptidase S26 family
GH983_05585	COG0571	ribonuclease III activity
GH983_05590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GH983_05595	COG3180	Ammonia monooxygenase
GH983_05605	COG1381	Involved in DNA repair and RecF pathway recombination
GH983_05625	COG1418	mRNA catabolic process
GH983_05640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GH983_05645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GH983_05660	COG0668	transmembrane transport
GH983_05675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GH983_05680	COG0354	folic acid binding
GH983_05710	COG1183	phosphatidylcholine synthase activity
GH983_05715	COG0688	phosphatidylethanolamine metabolic process
GH983_05720	COG3706	GGDEF domain
GH983_05725	COG5265	(ABC) transporter
GH983_05740	COG2962	Rard protein
GH983_05745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH983_05775	COG0215	cysteine-tRNA ligase activity
GH983_05780	COG3706	GGDEF domain
GH983_05790	COG4221	oxidoreductase activity
GH983_05795	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GH983_05800	COG1286	toxin biosynthetic process
GH983_05815	COG3609	addiction module antidote protein, CC2985 family
GH983_05820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GH983_05845	COG0359	binds to the 23S rRNA
GH983_05855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GH983_05860	COG0360	Binds together with S18 to 16S ribosomal RNA
GH983_05870	COG0667	Aldo Keto reductase
GH983_05875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH983_05885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH983_05890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH983_05895	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GH983_05900	COG1561	YicC-like family, N-terminal region
GH983_05905	COG0194	GDP metabolic process
GH983_05910	COG3119	arylsulfatase activity
GH983_05920	COG0583	DNA-binding transcription factor activity
GH983_05925	COG0840	transmembrane signaling receptor activity
GH983_05930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH983_05935	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH983_05945	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GH983_05960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH983_05970	COG0840	transmembrane signaling receptor activity
GH983_05975	COG0488	(ABC) transporter
GH983_06005	COG0105	UTP biosynthetic process
GH983_06010	COG0314	molybdopterin synthase activity
GH983_06020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH983_06025	COG0322	excinuclease ABC activity
GH983_06030	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_06050	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GH983_06055	COG0243	molybdopterin cofactor binding
GH983_06065	COG1132	(ABC) transporter
GH983_06070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GH983_06075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH983_06080	COG0628	permease
GH983_06090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GH983_06130	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GH983_06140	COG2132	Multicopper oxidase
GH983_06170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GH983_06180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH983_06190	COG5001	Diguanylate cyclase
GH983_06190	COG3300	MHYT domain
GH983_06200	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GH983_06210	COG0113	porphobilinogen synthase activity
GH983_06235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GH983_06240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH983_06245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH983_06245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH983_06260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GH983_06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH983_06270	COG2814	Major facilitator Superfamily
GH983_06275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GH983_06295	COG0416	fatty acid biosynthetic process
GH983_06300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH983_06305	COG0776	regulation of translation
GH983_06345	COG0297	glycogen (starch) synthase activity
GH983_06370	COG1612	heme a metabolic process
GH983_06375	COG3384	dioxygenase
GH983_06380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GH983_06385	COG0010	Belongs to the arginase family
GH983_06390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH983_06395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GH983_06405	COG1832	CoA-binding protein
GH983_06415	COG1832	CoA-binding protein
GH983_06440	COG2378	regulation of single-species biofilm formation
GH983_06450	COG5001	Diguanylate cyclase
GH983_06455	COG0740	serine-type endopeptidase activity
GH983_06460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GH983_06465	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH983_06475	COG0697	spore germination
GH983_06485	COG0667	Aldo Keto reductase
GH983_06500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GH983_06510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_06535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH983_06540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH983_06545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH983_06550	COG0649	NAD binding
GH983_06560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GH983_06565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH983_06570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH983_06570	COG3743	rRNA binding
GH983_06580	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH983_06585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH983_06595	COG0713	ATP synthesis coupled electron transport
GH983_06610	COG1007	ATP synthesis coupled electron transport
GH983_06635	COG0442	prolyl-tRNA aminoacylation
GH983_06645	COG1136	(ABC) transporter
GH983_06650	COG0587	DNA-directed DNA polymerase activity
GH983_06665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH983_06680	COG0784	Response regulator, receiver
GH983_06685	COG0745	RESPONSE REGULATOR receiver
GH983_06685	COG3706	GGDEF domain
GH983_06690	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GH983_06695	COG0477	Major facilitator Superfamily
GH983_06710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GH983_06710	COG1754	DNA topoisomerase type I activity
GH983_06720	COG0758	DNA mediated transformation
GH983_06725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GH983_06730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH983_06735	COG0540	Belongs to the ATCase OTCase family
GH983_06740	COG1960	acyl-CoA dehydrogenase activity
GH983_06760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GH983_06765	COG2824	Alkylphosphonate utilization operon protein PhnA
GH983_06770	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GH983_06775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH983_06780	COG0154	amidase activity
GH983_06800	COG3811	Belongs to the UPF0386 family
GH983_06805	COG0454	-acetyltransferase
GH983_06815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH983_06860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH983_06885	COG0243	molybdopterin cofactor binding
GH983_06905	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GH983_06915	COG0511	ligase activity, forming carbon-carbon bonds
GH983_06920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH983_06930	COG0436	Aminotransferase
GH983_06940	COG1530	ribonuclease E activity
GH983_06945	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH983_06945	COG1388	LysM domain
GH983_06970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GH983_06985	COG1215	transferase activity, transferring glycosyl groups
GH983_06990	COG3769	mannosylglycerate metabolic process
GH983_07010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH983_07045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GH983_07050	COG0081	regulation of translation
GH983_07055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GH983_07060	COG0222	ribosome binding
GH983_07065	COG0085	RNA polymerase activity
GH983_07070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GH983_07080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GH983_07085	COG0049	tRNA binding
GH983_07090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH983_07095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH983_07100	COG0051	transcription antitermination factor activity, RNA binding
GH983_07105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GH983_07110	COG0088	Forms part of the polypeptide exit tunnel
GH983_07115	COG0089	rRNA binding
GH983_07120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GH983_07125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GH983_07130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GH983_07135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GH983_07140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GH983_07145	COG0255	Belongs to the universal ribosomal protein uL29 family
GH983_07150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GH983_07155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GH983_07160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GH983_07165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GH983_07170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GH983_07175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GH983_07180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GH983_07185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GH983_07190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GH983_07195	COG1841	ribosomal large subunit assembly
GH983_07200	COG0200	Binds to the 23S rRNA
GH983_07210	COG0563	adenylate kinase activity
GH983_07215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GH983_07220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GH983_07225	COG0202	RNA polymerase activity
GH983_07230	COG0203	ribosomal protein L17
GH983_07240	COG4941	Belongs to the sigma-70 factor family
GH983_07250	COG3795	YCII-related domain
GH983_07255	COG3739	integral membrane protein
GH983_07275	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GH983_07280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH983_07290	COG0129	dihydroxy-acid dehydratase activity
GH983_07295	COG0235	Class ii aldolase
GH983_07315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH983_07315	COG1017	nitric oxide dioxygenase activity
GH983_07330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH983_07335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GH983_07345	COG1231	oxidoreductase activity
GH983_07365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH983_07370	COG0840	transmembrane signaling receptor activity
GH983_07375	COG0702	epimerase
GH983_07410	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GH983_07420	COG1546	Belongs to the CinA family
GH983_07420	COG1058	Belongs to the CinA family
GH983_07425	COG0655	NAD(P)H dehydrogenase (quinone) activity
GH983_07440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH983_07450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_07460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GH983_07465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH983_07480	COG3300	MHYT domain
GH983_07480	COG5001	Diguanylate cyclase
GH983_07485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH983_07490	COG0583	DNA-binding transcription factor activity
GH983_07495	COG0737	Belongs to the 5'-nucleotidase family
GH983_07510	COG1522	sequence-specific DNA binding
GH983_07515	COG0686	Belongs to the AlaDH PNT family
GH983_07540	COG2897	thiosulfate sulfurtransferase activity
GH983_07545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH983_07550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GH983_07565	COG4115	mRNA cleavage
GH983_07570	COG2161	toxin-antitoxin pair type II binding
GH983_07575	COG0415	Belongs to the DNA photolyase family
GH983_07605	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH983_07615	COG0525	valine-tRNA ligase activity
GH983_07625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GH983_07635	COG0316	Belongs to the HesB IscA family
GH983_07640	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GH983_07645	COG0018	arginyl-trna synthetase
GH983_07665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH983_07675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH983_07680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH983_07685	COG0805	protein transport
GH983_07690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GH983_07695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GH983_07700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH983_07740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GH983_07750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GH983_07755	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GH983_07775	COG2945	thiolester hydrolase activity
GH983_07780	COG1104	cysteine desulfurase activity
GH983_07785	COG0719	Fe-S assembly protein
GH983_07790	COG0396	ATPase activity
GH983_07795	COG0719	Fe-S assembly protein
GH983_07800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH983_07805	COG2151	metal-sulfur cluster biosynthetic enzyme
GH983_07810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH983_07815	COG2267	carboxylic ester hydrolase activity
GH983_07820	COG0251	oxidation-reduction process
GH983_07825	COG1335	isochorismatase
GH983_07830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH983_07835	COG0316	Belongs to the HesB IscA family
GH983_07875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH983_07875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH983_07880	COG0509	glycine decarboxylation via glycine cleavage system
GH983_07885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH983_07910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH983_07915	COG0564	pseudouridine synthase activity
GH983_07920	COG0546	phosphoglycolate phosphatase activity
GH983_07965	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GH983_07990	COG2875	Belongs to the precorrin methyltransferase family
GH983_07995	COG1957	nucleoside hydrolase
GH983_08020	COG0544	peptidyl-prolyl cis-trans isomerase activity
GH983_08025	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GH983_08040	COG2003	Belongs to the UPF0758 family
GH983_08045	COG0024	Methionine aminopeptidase
GH983_08055	COG3243	poly(R)-hydroxyalkanoic acid synthase
GH983_08065	COG0436	Aminotransferase
GH983_08110	COG1278	Cold shock
GH983_08140	COG1126	abc transporter atp-binding protein
GH983_08145	COG0765	amino acid transport
GH983_08150	COG4597	amino acid ABC transporter
GH983_08155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_08160	COG0626	cystathionine gamma-synthase activity
GH983_08175	COG2267	carboxylic ester hydrolase activity
GH983_08180	COG1024	Enoyl-CoA hydratase
GH983_08200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH983_08225	COG0537	adenosine 5'-monophosphoramidase activity
GH983_08250	COG0052	Belongs to the universal ribosomal protein uS2 family
GH983_08255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GH983_08260	COG0528	UMP kinase activity
GH983_08265	COG0233	cytoplasmic translational termination
GH983_08270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GH983_08280	COG0750	zinc metalloprotease
GH983_08285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH983_08290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH983_08295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH983_08300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH983_08305	COG3494	Protein of unknown function (DUF1009)
GH983_08310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH983_08315	COG0523	cobalamin synthesis protein
GH983_08320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GH983_08325	COG1121	(ABC) transporter
GH983_08330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH983_08335	COG0735	belongs to the Fur family
GH983_08350	COG1686	Belongs to the peptidase S11 family
GH983_08375	COG0516	GMP reductase activity
GH983_08375	COG0517	IMP dehydrogenase activity
GH983_08380	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH983_08385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH983_08390	COG0302	gtp cyclohydrolase
GH983_08400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GH983_08410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GH983_08425	COG0778	Nitroreductase
GH983_08445	COG0628	permease
GH983_08450	COG0187	DNA topoisomerase II activity
GH983_08460	COG0149	triose-phosphate isomerase activity
GH983_08465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GH983_08470	COG0504	CTP synthase activity
GH983_08475	COG0303	'Molybdopterin
GH983_08480	COG0315	cyclic pyranopterin monophosphate synthase activity
GH983_08485	COG0134	indole-3-glycerol-phosphate synthase activity
GH983_08490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GH983_08510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH983_08525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GH983_08530	COG0148	phosphopyruvate hydratase activity
GH983_08540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GH983_08545	COG0022	dehydrogenase e1 component
GH983_08545	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH983_08550	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH983_08565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH983_08575	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GH983_08605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GH983_08605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH983_08615	COG3852	Histidine kinase
GH983_08620	COG2204	response regulator
GH983_08625	COG5000	phosphorelay sensor kinase activity
GH983_08630	COG2204	response regulator
GH983_08635	COG0569	domain protein
GH983_08645	COG1923	regulation of RNA biosynthetic process
GH983_08650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH983_08655	COG1032	radical SAM domain protein
GH983_08660	COG1719	4-vinyl reductase, 4VR
GH983_08670	COG3956	TIGRFAM MazG family protein
GH983_08680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH983_08680	COG1648	precorrin-2 dehydrogenase activity
GH983_08710	COG0646	methionine synthase
GH983_08710	COG1410	methionine synthase
GH983_08715	COG4175	Glycine betaine
GH983_08715	COG0517	IMP dehydrogenase activity
GH983_08720	COG4176	ABC-type proline glycine betaine transport system permease component
GH983_08740	COG3608	succinylglutamate desuccinylase aspartoacylase
GH983_08740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH983_08750	COG0542	response to heat
GH983_08775	COG0745	RESPONSE REGULATOR receiver
GH983_08775	COG3706	GGDEF domain
GH983_08785	COG0683	leucine binding
GH983_08830	COG1686	Belongs to the peptidase S11 family
GH983_08835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GH983_08845	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH983_08850	COG0084	hydrolase, TatD family'
GH983_08860	COG2801	Transposase and inactivated derivatives
GH983_08875	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_08880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH983_08885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH983_08895	COG0343	queuine tRNA-ribosyltransferase activity
GH983_08900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH983_08905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH983_08910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH983_08915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GH983_08930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH983_08935	COG2095	MarC family integral membrane protein
GH983_08940	COG0629	single-stranded DNA binding
GH983_08945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH983_08960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH983_08960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH983_08965	COG0347	Belongs to the P(II) protein family
GH983_08970	COG0174	glutamine synthetase
GH983_08990	COG4166	transmembrane transport
GH983_09000	COG0697	spore germination
GH983_09005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GH983_09015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GH983_09025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH983_09030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH983_09035	COG2186	Transcriptional regulator
GH983_09055	COG1129	ABC transporter
GH983_09060	COG1183	phosphatidylcholine synthase activity
GH983_09065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH983_09070	COG0679	Auxin Efflux Carrier
GH983_09075	COG0785	Cytochrome C biogenesis protein
GH983_09085	COG3485	protocatechuate 3,4-dioxygenase
GH983_09095	COG1733	regulation of RNA biosynthetic process
GH983_09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_09105	COG0577	efflux transmembrane transporter activity
GH983_09105	COG1136	(ABC) transporter
GH983_09110	COG1136	(ABC) transporter
GH983_09110	COG0577	efflux transmembrane transporter activity
GH983_09120	COG3698	Phosphodiester glycosidase
GH983_09130	COG5598	trimethylamine methyltransferase
GH983_09135	COG5012	cobalamin binding
GH983_09180	COG0646	methionine synthase
GH983_09180	COG1410	methionine synthase
GH983_09200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH983_09205	COG1309	transcriptional regulator
GH983_09220	COG0406	alpha-ribazole phosphatase activity
GH983_09230	COG0583	DNA-binding transcription factor activity
GH983_09255	COG0730	response to heat
GH983_09265	COG0840	transmembrane signaling receptor activity
GH983_09270	COG1607	acyl-coa hydrolase
GH983_09300	COG0556	nucleotide-excision repair
GH983_09320	COG0484	heat shock protein binding
GH983_09330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH983_09355	COG1760	l-serine dehydratase
GH983_09380	COG2239	Acts as a magnesium transporter
GH983_09385	COG0242	peptide deformylase activity
GH983_09400	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_09415	COG0321	lipoyl(octanoyl) transferase activity
GH983_09440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GH983_09450	COG1671	Belongs to the UPF0178 family
GH983_09455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GH983_09465	COG3507	Belongs to the glycosyl hydrolase 43 family
GH983_09470	COG0667	Aldo Keto reductase
GH983_09475	COG0673	inositol 2-dehydrogenase activity
GH983_09495	COG0395	ABC-type sugar transport system, permease component
GH983_09515	COG3706	GGDEF domain
GH983_09525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GH983_09590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH983_09600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH983_09605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH983_09610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH983_09655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH983_09660	COG2833	Protein of unknown function (DUF455)
GH983_09665	COG0739	heme binding
GH983_09670	COG0513	Belongs to the DEAD box helicase family
GH983_09685	COG2068	MobA-Related Protein
GH983_09690	COG3608	succinylglutamate desuccinylase aspartoacylase
GH983_09690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH983_09705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH983_09710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH983_09720	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_09740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GH983_09765	COG5001	Diguanylate cyclase
GH983_09775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH983_09780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH983_09790	COG0047	phosphoribosylformylglycinamidine synthase activity
GH983_09805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH983_09810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH983_09835	COG2814	Major facilitator Superfamily
GH983_09840	COG0483	inositol monophosphate 1-phosphatase activity
GH983_09860	COG0483	inositol monophosphate 1-phosphatase activity
GH983_09865	COG0037	tRNA processing
GH983_09870	COG2066	Belongs to the glutaminase family
GH983_09875	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GH983_09880	COG1686	Belongs to the peptidase S11 family
GH983_09885	COG2195	Cleaves the N-terminal amino acid of tripeptides
GH983_09905	COG1253	flavin adenine dinucleotide binding
GH983_09910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GH983_09915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GH983_09930	COG0538	isocitrate dehydrogenase activity
GH983_09940	COG0659	secondary active sulfate transmembrane transporter activity
GH983_09950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH983_09955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GH983_09965	COG2313	pseudouridylate synthase activity
GH983_09980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH983_09990	COG3106	COG3106 Predicted ATPase
GH983_09995	COG3768	UPF0283 membrane protein
GH983_10005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GH983_10015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH983_10025	COG0633	Ferredoxin
GH983_10050	COG1127	ABC transporter
GH983_10055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GH983_10065	COG0280	phosphate acetyltransferase
GH983_10065	COG0281	malic enzyme
GH983_10085	COG0778	Nitroreductase
GH983_10090	COG0823	Involved in the tonB-independent uptake of proteins
GH983_10105	COG1368	sulfuric ester hydrolase activity
GH983_10120	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH983_10140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GH983_10145	COG0546	phosphoglycolate phosphatase activity
GH983_10155	COG0114	fumarate hydratase activity
GH983_10165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GH983_10165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GH983_10170	COG3706	GGDEF domain
GH983_10185	COG1846	Transcriptional regulator
GH983_10195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GH983_10215	COG0746	molybdenum cofactor guanylyltransferase activity
GH983_10220	COG1763	Mo-molybdopterin cofactor biosynthetic process
GH983_10225	COG2885	chlorophyll binding
GH983_10245	COG5425	PFAM Usg family protein
GH983_10265	COG2084	Dehydrogenase
GH983_10275	COG1522	sequence-specific DNA binding
GH983_10280	COG1573	uracil-dna glycosylase
GH983_10290	COG2202	Pas domain
GH983_10290	COG2205	protein histidine kinase activity
GH983_10300	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GH983_10305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GH983_10320	COG0842	Transport permease protein
GH983_10325	COG1131	(ABC) transporter
GH983_10330	COG0745	RESPONSE REGULATOR receiver
GH983_10330	COG3706	GGDEF domain
GH983_10345	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GH983_10345	COG3264	Mechanosensitive ion channel
GH983_10360	COG4558	Periplasmic binding protein
GH983_10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_10370	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GH983_10380	COG0384	phenazine biosynthesis protein PhzF
GH983_10395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH983_10400	COG2203	Gaf domain
GH983_10400	COG3706	GGDEF domain
GH983_10400	COG4251	negative regulation of phosphorylation
GH983_10400	COG5001	Diguanylate cyclase
GH983_10405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GH983_10445	COG1522	sequence-specific DNA binding
GH983_10450	COG1794	racemase activity, acting on amino acids and derivatives
GH983_10455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GH983_10475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH983_10500	COG0656	L-ascorbic acid biosynthetic process
GH983_10505	COG0640	Transcriptional regulator
GH983_10510	COG0440	acetolactate synthase activity
GH983_10515	COG0028	Belongs to the TPP enzyme family
GH983_10525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GH983_10530	COG3830	Belongs to the UPF0237 family
GH983_10530	COG0560	Phosphoserine phosphatase
GH983_10540	COG3300	MHYT domain
GH983_10540	COG5001	Diguanylate cyclase
GH983_10555	COG0330	HflC and HflK could
GH983_10560	COG0330	HflC and HflK could
GH983_10570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH983_10600	COG0277	FAD linked oxidase domain protein
GH983_10605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH983_10625	COG1435	thymidine kinase activity
GH983_10635	COG4993	Dehydrogenase
GH983_10640	COG1335	isochorismatase
GH983_10645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH983_10650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GH983_10675	COG2264	protein methyltransferase activity
GH983_10680	COG1999	signal sequence binding
GH983_10695	COG2972	Histidine kinase
GH983_10695	COG0840	transmembrane signaling receptor activity
GH983_10700	COG0835	chemotaxis
GH983_10720	COG0456	acetyltransferase
GH983_10720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH983_10740	COG2199	diguanylate cyclase activity
GH983_10745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH983_10755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GH983_10765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH983_10775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GH983_10780	COG0849	cell division
GH983_10785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GH983_10790	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH983_10795	COG3706	GGDEF domain
GH983_10800	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GH983_10805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH983_10810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GH983_10820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GH983_10825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH983_10835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH983_10850	COG0275	rRNA processing
GH983_10855	COG2001	Belongs to the MraZ family
GH983_10875	COG3023	N-Acetylmuramoyl-L-alanine amidase
GH983_10880	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GH983_10905	COG5001	Diguanylate cyclase
GH983_10905	COG3300	MHYT domain
GH983_10940	COG0840	transmembrane signaling receptor activity
GH983_10955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH983_10960	COG0028	Belongs to the TPP enzyme family
GH983_10970	COG0697	spore germination
GH983_10995	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_11020	COG0174	glutamine synthetase
GH983_11025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH983_11060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GH983_11105	COG2968	Membrane
GH983_11165	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH983_11175	COG0411	ABC transporter
GH983_11180	COG1802	Transcriptional regulator
GH983_11200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH983_11215	COG0583	DNA-binding transcription factor activity
GH983_11225	COG0697	spore germination
GH983_11235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH983_11260	COG4459	periplasmic nitrate reductase
GH983_11285	COG3005	denitrification pathway
GH983_11295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH983_11325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH983_11335	COG0714	Associated with various cellular activities
GH983_11340	COG3256	nitric oxide reductase
GH983_11375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_11420	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GH983_11425	COG0840	transmembrane signaling receptor activity
GH983_11435	COG3300	MHYT domain
GH983_11435	COG5001	Diguanylate cyclase
GH983_11465	COG2132	Multicopper oxidase
GH983_11500	COG0434	BtpA family
GH983_11505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH983_11515	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GH983_11520	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_11525	COG1129	ABC transporter
GH983_11530	COG1879	ABC-type sugar transport system periplasmic component
GH983_11535	COG1609	Transcriptional regulator
GH983_11545	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GH983_11570	COG1012	belongs to the aldehyde dehydrogenase family
GH983_11575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH983_11580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_11585	COG0765	amino acid transport
GH983_11635	COG3626	phosphonate metabolism
GH983_11640	COG3627	carbon phosphorus lyase activity
GH983_11645	COG4107	phosphonate C-P lyase system protein PhnK
GH983_11650	COG4778	phosphonate C-P lyase system protein PhnL
GH983_11660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GH983_11670	COG3639	organic phosphonate transmembrane transporter activity
GH983_11675	COG3639	organic phosphonate transmembrane transporter activity
GH983_11700	COG0395	ABC-type sugar transport system, permease component
GH983_11710	COG3842	ATPase activity
GH983_11715	COG3842	ATPase activity
GH983_11740	COG4176	ABC-type proline glycine betaine transport system permease component
GH983_11765	COG0402	S-adenosylhomocysteine deaminase activity
GH983_11780	COG1116	anion transmembrane transporter activity
GH983_11825	COG0583	DNA-binding transcription factor activity
GH983_11850	COG0405	Gamma-glutamyltransferase
GH983_11890	COG0432	Pfam Uncharacterised protein family UPF0047
GH983_11895	COG4702	Belongs to the UPF0303 family
GH983_11915	COG1473	amidohydrolase
GH983_11935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH983_11945	COG0358	DNA primase activity
GH983_11965	COG0505	Belongs to the CarA family
GH983_11970	COG0534	Mate efflux family protein
GH983_11980	COG2321	neutral zinc metallopeptidase
GH983_12000	COG1063	alcohol dehydrogenase
GH983_12010	COG0840	transmembrane signaling receptor activity
GH983_12025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GH983_12055	COG5002	protein histidine kinase activity
GH983_12060	COG0745	RESPONSE REGULATOR receiver
GH983_12080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH983_12095	COG1522	sequence-specific DNA binding
GH983_12100	COG0492	ferredoxin-NADP+ reductase activity
GH983_12105	COG0583	DNA-binding transcription factor activity
GH983_12115	COG1902	pentaerythritol trinitrate reductase activity
GH983_12150	COG2133	pyrroloquinoline quinone binding
GH983_12165	COG2133	pyrroloquinoline quinone binding
GH983_12170	COG1278	Cold shock
GH983_12180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH983_12190	COG1846	Transcriptional regulator
GH983_12195	COG0745	RESPONSE REGULATOR receiver
GH983_12200	COG2205	protein histidine kinase activity
GH983_12205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH983_12225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH983_12250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH983_12260	COG0840	transmembrane signaling receptor activity
GH983_12270	COG1012	belongs to the aldehyde dehydrogenase family
GH983_12280	COG5001	Diguanylate cyclase
GH983_12280	COG3300	MHYT domain
GH983_12285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GH983_12300	COG0193	aminoacyl-tRNA hydrolase activity
GH983_12305	COG2890	protein-(glutamine-N5) methyltransferase activity
GH983_12320	COG0251	oxidation-reduction process
GH983_12330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH983_12335	COG0012	GTP binding
GH983_12360	COG0386	Belongs to the glutathione peroxidase family
GH983_12370	COG1280	lysine exporter protein (LysE YggA)
GH983_12375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GH983_12380	COG2857	Cytochrome c1
GH983_12380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH983_12395	COG1132	(ABC) transporter
GH983_12420	COG1132	(ABC) transporter
GH983_12425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GH983_12445	COG0408	coproporphyrinogen oxidase activity
GH983_12460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH983_12465	COG0617	tRNA 3'-terminal CCA addition
GH983_12480	COG0714	Associated with various cellular activities
GH983_12500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH983_12505	COG0454	-acetyltransferase
GH983_12520	COG0435	Glutathione S-transferase
GH983_12535	COG0596	Alpha beta hydrolase
GH983_12535	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH983_12540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH983_12560	COG3135	benzoate transporter
GH983_12565	COG5001	Diguanylate cyclase
GH983_12565	COG5002	protein histidine kinase activity
GH983_12565	COG3447	MASE1 domain protein
GH983_12570	COG0019	diaminopimelate decarboxylase activity
GH983_12610	COG0740	serine-type endopeptidase activity
GH983_12615	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GH983_12620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GH983_12630	COG1522	sequence-specific DNA binding
GH983_12670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GH983_12710	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GH983_12715	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GH983_12720	COG4774	siderophore transport
GH983_12735	COG0512	Glutamine amidotransferase of anthranilate synthase
GH983_12735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH983_12745	COG4771	TonB-dependent receptor
GH983_12750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GH983_12755	COG0506	proline dehydrogenase activity
GH983_12755	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GH983_12755	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GH983_12765	COG2197	response regulator
GH983_12815	COG4176	ABC-type proline glycine betaine transport system permease component
GH983_12820	COG4175	Glycine betaine
GH983_12890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GH983_12905	COG4115	mRNA cleavage
GH983_12920	COG0366	Alpha amylase catalytic
GH983_12925	COG0297	glycogen (starch) synthase activity
GH983_12925	COG0438	transferase activity, transferring glycosyl groups
GH983_12930	COG1160	GTP binding
GH983_12955	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GH983_12965	COG0024	Methionine aminopeptidase
GH983_12975	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_12985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH983_13000	COG0583	DNA-binding transcription factor activity
GH983_13010	COG0402	S-adenosylhomocysteine deaminase activity
GH983_13020	COG1304	FMN binding
GH983_13030	COG2351	hydroxyisourate hydrolase activity
GH983_13035	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GH983_13040	COG0534	Mate efflux family protein
GH983_13050	COG0174	glutamine synthetase
GH983_13060	COG4266	Belongs to the allantoicase family
GH983_13065	COG3648	Uricase
GH983_13065	COG3195	allantoin biosynthetic process
GH983_13070	COG1064	alcohol dehydrogenase
GH983_13090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GH983_13095	COG2022	thiamine diphosphate biosynthetic process
GH983_13095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_13100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GH983_13100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_13105	COG2205	protein histidine kinase activity
GH983_13105	COG0784	Response regulator, receiver
GH983_13105	COG5002	protein histidine kinase activity
GH983_13110	COG5598	trimethylamine methyltransferase
GH983_13115	COG0840	transmembrane signaling receptor activity
GH983_13130	COG4335	DNA alkylation repair
GH983_13140	COG0513	Belongs to the DEAD box helicase family
GH983_13150	COG2308	Evidence 4 Homologs of previously reported genes of
GH983_13180	COG0318	PFAM AMP-dependent synthetase and ligase
GH983_13185	COG0385	Bile acid
GH983_13220	COG0488	(ABC) transporter
GH983_13225	COG2346	COG2346, Truncated hemoglobins
GH983_13245	COG0493	'glutamate synthase
GH983_13260	COG3932	Exopolysaccharide synthesis, ExoD
GH983_13270	COG1309	transcriptional regulator
GH983_13305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_13310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_13315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH983_13320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_13330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH983_13335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GH983_13340	COG0830	nickel cation binding
GH983_13345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GH983_13350	COG3706	GGDEF domain
GH983_13360	COG0804	urea catabolic process
GH983_13365	COG1442	glycosyl transferase family 8
GH983_13370	COG3755	Protein conserved in bacteria
GH983_13375	COG0832	Belongs to the urease beta subunit family
GH983_13380	COG0831	urea catabolic process
GH983_13385	COG0829	nickel cation binding
GH983_13435	COG2205	protein histidine kinase activity
GH983_13435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_13450	COG0683	leucine binding
GH983_13465	COG0411	ABC transporter
GH983_13485	COG1408	metallophosphoesterase
GH983_13495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH983_13495	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH983_13500	COG4311	Sarcosine oxidase, delta subunit
GH983_13505	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_13535	COG2388	GCN5-related N-acetyl-transferase
GH983_13575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH983_13585	COG0564	pseudouridine synthase activity
GH983_13590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH983_13600	COG1131	(ABC) transporter
GH983_13610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH983_13615	COG0697	spore germination
GH983_13620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GH983_13640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_13645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GH983_13665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH983_13675	COG0346	lactoylglutathione lyase activity
GH983_13685	COG1301	dicarboxylic acid transport
GH983_13690	COG4191	Histidine kinase
GH983_13695	COG2204	response regulator
GH983_13700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GH983_13715	COG4948	Mandelate Racemase Muconate Lactonizing
GH983_13720	COG0482	sulfurtransferase activity
GH983_13745	COG0673	inositol 2-dehydrogenase activity
GH983_13770	COG1294	oxidase, subunit
GH983_13775	COG1271	oxidase subunit
GH983_13780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GH983_13795	COG0840	transmembrane signaling receptor activity
GH983_13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH983_13805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GH983_13820	COG0632	four-way junction helicase activity
GH983_13835	COG2255	four-way junction helicase activity
GH983_13840	COG0494	nUDIX hydrolase
GH983_13845	COG2318	DinB family
GH983_13855	COG0824	Thioesterase
GH983_13875	COG0823	Involved in the tonB-independent uptake of proteins
GH983_13880	COG2885	chlorophyll binding
GH983_13890	COG0037	tRNA processing
GH983_13895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH983_13900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH983_13905	COG0217	transcriptional regulatory protein
GH983_13920	COG0840	transmembrane signaling receptor activity
GH983_13925	COG1692	metallophosphoesterase
GH983_13930	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GH983_13935	COG2972	Histidine kinase
GH983_13935	COG0840	transmembrane signaling receptor activity
GH983_13985	COG1403	HNH endonuclease
GH983_14045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GH983_14055	COG0126	phosphoglycerate kinase activity
GH983_14060	COG3588	fructose-bisphosphate aldolase
GH983_14065	COG0384	phenazine biosynthesis protein PhzF
GH983_14095	COG0254	rRNA binding
GH983_14100	COG1132	(ABC) transporter
GH983_14110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GH983_14110	COG2885	chlorophyll binding
GH983_14120	COG0483	inositol monophosphate 1-phosphatase activity
GH983_14125	COG3174	membrane
GH983_14145	COG0640	Transcriptional regulator
GH983_14160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GH983_14165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GH983_14170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GH983_14175	COG0457	Tetratricopeptide repeat
GH983_14185	COG0469	pyruvate kinase activity
GH983_14205	COG3750	Belongs to the UPF0335 family
GH983_14215	COG2204	response regulator
GH983_14225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH983_14225	COG0512	Glutamine amidotransferase of anthranilate synthase
GH983_14255	COG5310	Homospermidine synthase
GH983_14265	COG0737	Belongs to the 5'-nucleotidase family
GH983_14270	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GH983_14280	COG0840	transmembrane signaling receptor activity
GH983_14280	COG2972	Histidine kinase
GH983_14285	COG0330	HflC and HflK could
GH983_14295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GH983_14305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GH983_14305	COG0517	IMP dehydrogenase activity
GH983_14315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH983_14320	COG2951	lytic endotransglycosylase activity
GH983_14335	COG0070	glutamate synthase
GH983_14335	COG0067	glutamate synthase
GH983_14335	COG0069	glutamate synthase activity
GH983_14350	COG3220	belongs to the UPF0276 family
GH983_14365	COG0071	Belongs to the small heat shock protein (HSP20) family
GH983_14375	COG0483	inositol monophosphate 1-phosphatase activity
GH983_14405	COG0662	Cupin 2, conserved barrel domain protein
GH983_14405	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GH983_14415	COG2307	Protein conserved in bacteria
GH983_14415	COG2308	Evidence 4 Homologs of previously reported genes of
GH983_14430	COG0058	SHG alpha-glucan phosphorylase activity
GH983_14435	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GH983_14440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GH983_14445	COG0297	glycogen (starch) synthase activity
GH983_14450	COG0033	Phosphoglucomutase
GH983_14465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GH983_14475	COG0431	NADPH-dependent FMN reductase
GH983_14495	COG2337	Toxic component of a toxin-antitoxin (TA) module
GH983_14510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH983_14510	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH983_14520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_14525	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GH983_14545	COG5001	Diguanylate cyclase
GH983_14560	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH983_14570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH983_14575	COG1609	Transcriptional regulator
GH983_14580	COG1846	Transcriptional regulator
GH983_14600	COG0523	cobalamin synthesis protein
GH983_14610	COG0840	transmembrane signaling receptor activity
GH983_14620	COG3047	cAMP biosynthetic process
GH983_14635	COG0583	DNA-binding transcription factor activity
GH983_14645	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GH983_14665	COG0800	Aldolase
GH983_14680	COG4172	Belongs to the ABC transporter superfamily
GH983_14685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_14690	COG0601	transmembrane transport
GH983_14695	COG0747	negative chemotaxis
GH983_14710	COG5001	Diguanylate cyclase
GH983_14720	COG1733	regulation of RNA biosynthetic process
GH983_14730	COG0673	inositol 2-dehydrogenase activity
GH983_14745	COG1879	ABC-type sugar transport system periplasmic component
GH983_14750	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_14755	COG1129	ABC transporter
GH983_14760	COG1609	Transcriptional regulator
GH983_14765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH983_14775	COG2115	Belongs to the xylose isomerase family
GH983_14780	COG1070	Carbohydrate kinase
GH983_14785	COG1609	Transcriptional regulator
GH983_14795	COG1566	PFAM secretion protein HlyD family protein
GH983_14800	COG1309	transcriptional regulator
GH983_14805	COG1253	flavin adenine dinucleotide binding
GH983_14810	COG3273	potassium ion transport
GH983_14810	COG0471	metal ion transport
GH983_14815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH983_14820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GH983_14855	COG1121	(ABC) transporter
GH983_14860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH983_14865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH983_14875	COG0697	spore germination
GH983_14880	COG0583	DNA-binding transcription factor activity
GH983_14885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GH983_14890	COG3842	ATPase activity
GH983_14895	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_14900	COG1177	transmembrane transport
GH983_14925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GH983_14945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GH983_14965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_14975	COG4172	Belongs to the ABC transporter superfamily
GH983_14980	COG1473	amidohydrolase
GH983_14990	COG0601	transmembrane transport
GH983_14995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_15000	COG0671	phosphoesterase, PA-phosphatase related
GH983_15005	COG3191	aminopeptidase activity
GH983_15015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH983_15020	COG3454	Phosphonate metabolism
GH983_15030	COG0154	amidase activity
GH983_15035	COG3842	ATPase activity
GH983_15040	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_15045	COG1177	transmembrane transport
GH983_15060	COG0402	S-adenosylhomocysteine deaminase activity
GH983_15085	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_15100	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GH983_15115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH983_15160	COG0784	Response regulator, receiver
GH983_15175	COG3237	CsbD-like
GH983_15195	COG0625	glutathione transferase activity
GH983_15200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH983_15205	COG1024	Enoyl-CoA hydratase
GH983_15220	COG1396	sequence-specific DNA binding
GH983_15220	COG3800	Transcriptional regulator
GH983_15225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH983_15230	COG0625	glutathione transferase activity
GH983_15265	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_15270	COG3842	ATPase activity
GH983_15275	COG1487	ribonuclease activity
GH983_15295	COG0583	DNA-binding transcription factor activity
GH983_15315	COG3718	enzyme involved in inositol metabolism
GH983_15330	COG3962	Belongs to the TPP enzyme family
GH983_15335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH983_15345	COG0673	inositol 2-dehydrogenase activity
GH983_15360	COG1609	Transcriptional regulator
GH983_15390	COG2200	EAL domain
GH983_15400	COG0745	RESPONSE REGULATOR receiver
GH983_15435	COG0840	transmembrane signaling receptor activity
GH983_15435	COG2972	Histidine kinase
GH983_15440	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GH983_15450	COG1486	melibiose metabolic process
GH983_15455	COG1175	transmembrane transport
GH983_15460	COG0395	ABC-type sugar transport system, permease component
GH983_15465	COG3842	ATPase activity
GH983_15480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GH983_15485	COG3002	Belongs to the UPF0753 family
GH983_15490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH983_15510	COG1595	DNA-templated transcription, initiation
GH983_15525	COG3485	protocatechuate 3,4-dioxygenase
GH983_15530	COG3485	protocatechuate 3,4-dioxygenase
GH983_15535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH983_15540	COG2267	carboxylic ester hydrolase activity
GH983_15545	COG0583	DNA-binding transcription factor activity
GH983_15550	COG1414	Transcriptional regulator
GH983_15560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GH983_15575	COG5001	Diguanylate cyclase
GH983_15575	COG3300	MHYT domain
GH983_15580	COG3142	Participates in the control of copper homeostasis
GH983_15600	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_15605	COG1737	Transcriptional regulator
GH983_15635	COG3842	ATPase activity
GH983_15645	COG0395	ABC-type sugar transport system, permease component
GH983_15650	COG1175	transmembrane transport
GH983_15655	COG0673	inositol 2-dehydrogenase activity
GH983_15665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GH983_15670	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GH983_15675	COG1940	carbohydrate kinase activity
GH983_15695	COG0395	ABC-type sugar transport system, permease component
GH983_15700	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_15710	COG3842	ATPase activity
GH983_15720	COG2186	Transcriptional regulator
GH983_15725	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_15730	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_15735	COG1129	ABC transporter
GH983_15740	COG1879	ABC-type sugar transport system periplasmic component
GH983_15750	COG0835	chemotaxis
GH983_15765	COG0640	Transcriptional regulator
GH983_15775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_15790	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
GH983_15800	COG1233	COG1233 Phytoene dehydrogenase and related
GH983_15805	COG1562	ergosterol biosynthetic process
GH983_15825	COG0142	geranyltranstransferase activity
GH983_15830	COG0500	methyltransferase
GH983_15835	COG1063	alcohol dehydrogenase
GH983_15840	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GH983_15845	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GH983_15850	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GH983_15885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GH983_15890	COG0156	8-amino-7-oxononanoate synthase activity
GH983_15900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GH983_15935	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
GH983_15940	COG1429	ligase activity, forming nitrogen-metal bonds
GH983_15945	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GH983_15950	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
GH983_15970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GH983_15975	COG2211	Major facilitator Superfamily
GH983_15980	COG0644	oxidoreductase
GH983_15990	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GH983_16000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GH983_16030	COG4989	oxidoreductase activity
GH983_16050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_16055	COG2855	membrane
GH983_16065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GH983_16070	COG2218	PFAM glutamate synthase alpha subunit domain protein
GH983_16075	COG0069	glutamate synthase activity
GH983_16110	COG0673	inositol 2-dehydrogenase activity
GH983_16115	COG1609	Transcriptional regulator
GH983_16140	COG3534	alpha-L-arabinofuranosidase
GH983_16145	COG3842	ATPase activity
GH983_16155	COG0395	ABC-type sugar transport system, permease component
GH983_16170	COG4136	ATPase activity
GH983_16175	COG4135	transport system, permease component
GH983_16180	COG4134	Bacterial extracellular solute-binding protein
GH983_16200	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH983_16210	COG0583	DNA-binding transcription factor activity
GH983_16230	COG0583	DNA-binding transcription factor activity
GH983_16235	COG3485	protocatechuate 3,4-dioxygenase
GH983_16265	COG4177	L-phenylalanine transmembrane transporter activity
GH983_16275	COG3485	protocatechuate 3,4-dioxygenase
GH983_16280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GH983_16300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH983_16315	COG0601	transmembrane transport
GH983_16325	COG0444	Belongs to the ABC transporter superfamily
GH983_16330	COG1124	(ABC) transporter
GH983_16340	COG1960	acyl-CoA dehydrogenase activity
GH983_16345	COG0183	Belongs to the thiolase family
GH983_16355	COG2169	Transcriptional regulator
GH983_16380	COG1960	acyl-CoA dehydrogenase activity
GH983_16385	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH983_16395	COG2030	dehydratase
GH983_16415	COG1178	ABC-type Fe3 transport system permease component
GH983_16440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GH983_16450	COG2274	protein secretion by the type I secretion system
GH983_16475	COG1032	radical SAM domain protein
GH983_16480	COG1802	Transcriptional regulator
GH983_16490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH983_16505	COG0601	transmembrane transport
GH983_16510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_16515	COG0444	Belongs to the ABC transporter superfamily
GH983_16520	COG4608	Belongs to the ABC transporter superfamily
GH983_16530	COG0402	S-adenosylhomocysteine deaminase activity
GH983_16540	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_16555	COG0745	RESPONSE REGULATOR receiver
GH983_16565	COG2391	methyltransferase activity
GH983_16575	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH983_16590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH983_16595	COG0737	Belongs to the 5'-nucleotidase family
GH983_16600	COG3258	Cytochrome c
GH983_16625	COG0785	Cytochrome C biogenesis protein
GH983_16650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GH983_16650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH983_16655	COG1388	LysM domain
GH983_16655	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_16660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH983_16670	COG0745	RESPONSE REGULATOR receiver
GH983_16675	COG0642	Histidine kinase
GH983_16695	COG0730	response to heat
GH983_16715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH983_16720	COG2207	Transcriptional regulator
GH983_16760	COG1215	transferase activity, transferring glycosyl groups
GH983_16790	COG3257	ureidoglycine aminohydrolase activity
GH983_16795	COG1126	abc transporter atp-binding protein
GH983_16810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_16815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_16830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH983_16835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH983_16840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH983_16860	COG0697	spore germination
GH983_16865	COG0534	Mate efflux family protein
GH983_16915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH983_16920	COG1309	transcriptional regulator
GH983_16940	COG0789	Transcriptional regulator
GH983_16945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GH983_16955	COG0583	DNA-binding transcription factor activity
GH983_16965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH983_17005	COG0546	phosphoglycolate phosphatase activity
GH983_17005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GH983_17040	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH983_17050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH983_17065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_17070	COG1012	belongs to the aldehyde dehydrogenase family
GH983_17085	COG0848	biopolymer transport protein
GH983_17100	COG0307	riboflavin synthase, alpha
GH983_17115	COG1285	pathogenesis
GH983_17120	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_17140	COG1960	acyl-CoA dehydrogenase activity
GH983_17145	COG0583	DNA-binding transcription factor activity
GH983_17150	COG2373	Large extracellular alpha-helical protein
GH983_17155	COG4953	penicillin-binding protein 1C
GH983_17200	COG3932	Exopolysaccharide synthesis, ExoD
GH983_17215	COG0670	Belongs to the BI1 family
GH983_17220	COG4952	isomerase
GH983_17230	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_17230	COG3347	Dehydrogenase
GH983_17245	COG1129	ABC transporter
GH983_17255	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_17260	COG3254	rhamnose metabolic process
GH983_17265	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH983_17270	COG0697	spore germination
GH983_17275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_17280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH983_17285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH983_17295	COG1802	Transcriptional regulator
GH983_17300	COG0277	FAD linked oxidase domain protein
GH983_17305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_17310	COG2084	Dehydrogenase
GH983_17315	COG0129	dihydroxy-acid dehydratase activity
GH983_17325	COG0784	Response regulator, receiver
GH983_17330	COG4191	Histidine kinase
GH983_17330	COG0784	Response regulator, receiver
GH983_17355	COG5002	protein histidine kinase activity
GH983_17355	COG2176	DNA-directed DNA polymerase activity
GH983_17365	COG0517	IMP dehydrogenase activity
GH983_17370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GH983_17390	COG0583	DNA-binding transcription factor activity
GH983_17400	COG1116	anion transmembrane transporter activity
GH983_17405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH983_17410	COG0402	S-adenosylhomocysteine deaminase activity
GH983_17420	COG2249	NAD(P)H dehydrogenase (quinone) activity
GH983_17425	COG0251	oxidation-reduction process
GH983_17470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH983_17485	COG1609	Transcriptional regulator
GH983_17500	COG0673	inositol 2-dehydrogenase activity
GH983_17510	COG1115	amino acid carrier protein
GH983_17515	COG3273	potassium ion transport
GH983_17515	COG0471	metal ion transport
GH983_17525	COG4608	Belongs to the ABC transporter superfamily
GH983_17535	COG0601	transmembrane transport
GH983_17540	COG0747	negative chemotaxis
GH983_17550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH983_17555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GH983_17560	COG2080	2 iron, 2 sulfur cluster binding
GH983_17575	COG1120	ATPase activity
GH983_17580	COG2197	response regulator
GH983_17595	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
GH983_17620	COG4178	(ABC) transporter
GH983_17625	COG4771	TonB-dependent receptor
GH983_17630	COG4604	ABC transporter, ATP-binding protein
GH983_17635	COG3300	MHYT domain
GH983_17635	COG5001	Diguanylate cyclase
GH983_17665	COG3920	Histidine kinase
GH983_17670	COG4191	Histidine kinase
GH983_17670	COG0784	Response regulator, receiver
GH983_17675	COG0753	catalase activity
GH983_17680	COG3685	Protein conserved in bacteria
GH983_17685	COG0784	Response regulator, receiver
GH983_17685	COG4191	Histidine kinase
GH983_17690	COG4172	Belongs to the ABC transporter superfamily
GH983_17700	COG0747	negative chemotaxis
GH983_17710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH983_17735	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_17745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH983_17750	COG1940	carbohydrate kinase activity
GH983_17760	COG1921	L-seryl-tRNASec selenium transferase activity
GH983_17780	COG3964	amidohydrolase
GH983_17805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_17815	COG1522	sequence-specific DNA binding
GH983_17885	COG1196	nuclear chromosome segregation
GH983_17885	COG0741	lytic transglycosylase activity
GH983_17885	COG0739	heme binding
GH983_17890	COG0542	response to heat
GH983_17900	COG2890	protein-(glutamine-N5) methyltransferase activity
GH983_17905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GH983_17915	COG0527	aspartate kinase activity
GH983_17920	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GH983_17920	COG0392	lysyltransferase activity
GH983_17930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH983_17945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_17950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GH983_17960	COG2226	methyltransferase
GH983_17975	COG0494	nUDIX hydrolase
GH983_17980	COG0456	acetyltransferase
GH983_17985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GH983_17990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH983_17995	COG0653	protein targeting
GH983_18015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH983_18050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH983_18060	COG0300	oxidoreductase activity
GH983_18070	COG2096	Adenosyltransferase
GH983_18080	COG2086	electron transfer activity
GH983_18090	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH983_18095	COG4150	thiosulfate binding
GH983_18105	COG4208	sulfate ABC transporter
GH983_18110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GH983_18115	COG2200	EAL domain
GH983_18120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH983_18125	COG0165	Argininosuccinate lyase
GH983_18160	COG2884	Cell division ATP-binding protein ftsE
GH983_18180	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GH983_18190	COG0287	Prephenate dehydrogenase
GH983_18195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH983_18200	COG2226	methyltransferase
GH983_18205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH983_18230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GH983_18235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GH983_18265	COG4536	flavin adenine dinucleotide binding
GH983_18270	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GH983_18275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH983_18280	COG4974	Belongs to the 'phage' integrase family
GH983_18285	COG0825	malonyl-CoA metabolic process
GH983_18290	COG3034	peptidoglycan biosynthetic process
GH983_18295	COG0425	Belongs to the sulfur carrier protein TusA family
GH983_18295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH983_18300	COG0523	cobalamin synthesis protein
GH983_18305	COG1686	Belongs to the peptidase S11 family
GH983_18310	COG1473	amidohydrolase
GH983_18355	COG3685	Protein conserved in bacteria
GH983_18370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GH983_18375	COG3813	Protein conserved in bacteria
GH983_18385	COG0156	8-amino-7-oxononanoate synthase activity
GH983_18410	COG0729	surface antigen
GH983_18435	COG0835	chemotaxis
GH983_18440	COG0252	asparaginase activity
GH983_18450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH983_18455	COG3383	formate dehydrogenase (NAD+) activity
GH983_18480	COG0039	L-malate dehydrogenase activity
GH983_18490	COG1012	belongs to the aldehyde dehydrogenase family
GH983_18495	COG4948	Mandelate Racemase Muconate Lactonizing
GH983_18505	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GH983_18510	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH983_18515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GH983_18520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GH983_18525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH983_18545	COG4974	Belongs to the 'phage' integrase family
GH983_18570	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_18585	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH983_18595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GH983_18600	COG0045	succinate-CoA ligase (ADP-forming) activity
GH983_18605	COG0039	L-malate dehydrogenase activity
GH983_18610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GH983_18615	COG2845	Protein of unknown function (DUF459)
GH983_18645	COG2264	protein methyltransferase activity
GH983_18660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH983_18665	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH983_18670	COG0181	hydroxymethylbilane synthase activity
GH983_18710	COG1872	DUF167
GH983_18715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH983_18735	COG0339	signal peptide processing
GH983_18745	COG2814	Major facilitator Superfamily
GH983_18750	COG0137	argininosuccinate synthase activity
GH983_18755	COG3668	Plasmid stabilization system
GH983_18760	COG3609	addiction module antidote protein, CC2985 family
GH983_18765	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_18770	COG1280	lysine exporter protein (LysE YggA)
GH983_18775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH983_18790	COG2154	pterin-4-alpha-carbinolamine dehydratase
GH983_18795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GH983_18800	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GH983_18810	COG4181	ATPase activity
GH983_18820	COG0670	Belongs to the BI1 family
GH983_18825	COG1329	Transcriptional regulator
GH983_18865	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_18875	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
GH983_18885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GH983_18895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GH983_18900	COG0142	geranyltranstransferase activity
GH983_18905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH983_18915	COG2885	chlorophyll binding
GH983_18920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GH983_18925	COG2223	nitrite transmembrane transporter activity
GH983_18930	COG0697	spore germination
GH983_18935	COG1473	amidohydrolase
GH983_18940	COG1309	transcriptional regulator
GH983_18945	COG3459	Glycosyltransferase 36 associated
GH983_18950	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GH983_18965	COG3046	protein related to deoxyribodipyrimidine photolyase
GH983_18980	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_18990	COG3842	ATPase activity
GH983_19000	COG0395	ABC-type sugar transport system, permease component
GH983_19005	COG1175	transmembrane transport
GH983_19020	COG0246	Mannitol dehydrogenase
GH983_19025	COG1802	Transcriptional regulator
GH983_19030	COG2721	sulfolactate sulfo-lyase activity
GH983_19045	COG1879	ABC-type sugar transport system periplasmic component
GH983_19050	COG1129	ABC transporter
GH983_19055	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_19060	COG1063	alcohol dehydrogenase
GH983_19065	COG0400	carboxylic ester hydrolase activity
GH983_19070	COG0346	lactoylglutathione lyase activity
GH983_19080	COG0519	Catalyzes the synthesis of GMP from XMP
GH983_19080	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH983_19100	COG2188	Transcriptional regulator
GH983_19105	COG3624	Phosphonate C-P lyase system protein PhnG
GH983_19110	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GH983_19115	COG3626	phosphonate metabolism
GH983_19120	COG3627	carbon phosphorus lyase activity
GH983_19125	COG4107	phosphonate C-P lyase system protein PhnK
GH983_19130	COG4778	phosphonate C-P lyase system protein PhnL
GH983_19140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GH983_19150	COG3639	organic phosphonate transmembrane transporter activity
GH983_19155	COG3639	organic phosphonate transmembrane transporter activity
GH983_19160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GH983_19165	COG3454	Phosphonate metabolism
GH983_19170	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GH983_19180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH983_19185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GH983_19190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH983_19205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH983_19210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GH983_19215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GH983_19220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GH983_19225	COG0799	negative regulation of ribosome biogenesis
GH983_19230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GH983_19240	COG0793	Belongs to the peptidase S41A family
GH983_19250	COG0494	nUDIX hydrolase
GH983_19255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GH983_19275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH983_19280	COG0587	DNA-directed DNA polymerase activity
GH983_19330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GH983_19335	COG4783	chaperone-mediated protein folding
GH983_19350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH983_19355	COG0473	3-isopropylmalate dehydrogenase activity
GH983_19360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GH983_19365	COG0066	3-isopropylmalate dehydratase activity
GH983_19385	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GH983_19420	COG2835	tetraacyldisaccharide 4'-kinase activity
GH983_19425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH983_19430	COG1946	Acyl-CoA thioesterase
GH983_19435	COG0347	Belongs to the P(II) protein family
GH983_19440	COG0004	ammonium transporteR
GH983_19445	COG1674	ftsk spoiiie
GH983_19450	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GH983_19465	COG0745	RESPONSE REGULATOR receiver
GH983_19485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH983_19490	COG0765	amino acid transport
GH983_19510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH983_19520	COG0335	large ribosomal subunit rRNA binding
GH983_19530	COG0336	Belongs to the RNA methyltransferase TrmD family
GH983_19535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GH983_19540	COG0228	four-way junction DNA binding
GH983_19545	COG1605	Chorismate mutase
GH983_19545	COG0287	Prephenate dehydrogenase
GH983_19550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GH983_19560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GH983_19575	COG2022	thiamine diphosphate biosynthetic process
GH983_19585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GH983_19590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH983_19595	COG0552	protein localization to endoplasmic reticulum
GH983_19600	COG2917	probably involved in intracellular septation
GH983_19620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH983_19625	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH983_19630	COG4133	protoheme IX ABC transporter activity
GH983_19635	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GH983_19645	COG0800	Aldolase
GH983_19650	COG3734	2-keto-3-deoxy-galactonokinase
GH983_19675	COG4214	carbohydrate transport
GH983_19685	COG4213	ABC transporter substrate-binding protein
GH983_19705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GH983_19715	COG0288	reversible hydration of carbon dioxide
GH983_19730	COG2270	Major facilitator Superfamily
GH983_19735	COG0138	bifunctional purine biosynthesis protein purh
GH983_19745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GH983_19750	COG0501	Belongs to the peptidase M48B family
GH983_19765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH983_19780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GH983_19785	COG0495	leucyl-tRNA aminoacylation
GH983_19800	COG1475	DNA binding
GH983_19805	COG1192	Involved in chromosome partitioning
GH983_19810	COG0357	Ribosomal RNA small subunit methyltransferase G
GH983_19815	COG0445	tRNA wobble uridine modification
GH983_19820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GH983_19825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GH983_19835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH983_19840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GH983_19845	COG0424	maF-like protein
GH983_19850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH983_19855	COG0237	dephospho-CoA kinase activity
GH983_19860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH983_19865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GH983_19895	COG0187	DNA topoisomerase II activity
GH983_19920	COG0135	phosphoribosylanthranilate isomerase activity
GH983_19925	COG0133	tryptophan synthase activity
GH983_19930	COG0159	tryptophan synthase activity
GH983_19935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GH983_19960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH983_19965	COG3178	'Phosphotransferase
GH983_19970	COG2205	protein histidine kinase activity
GH983_19975	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH983_19980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH983_19985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GH983_19985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH983_19995	COG0642	Histidine kinase
GH983_20000	COG0745	RESPONSE REGULATOR receiver
GH983_20005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GH983_20015	COG3145	DNA-N1-methyladenine dioxygenase activity
GH983_20020	COG1072	(Pantothenic acid kinase))
GH983_20025	COG0140	phosphoribosyl-ATP diphosphatase activity
GH983_20030	COG0107	imidazoleglycerol-phosphate synthase activity
GH983_20035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH983_20040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH983_20045	COG0131	Imidazoleglycerol-phosphate dehydratase
GH983_20050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GH983_20055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GH983_20065	COG2124	cytochrome p450
GH983_20075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GH983_20080	COG1376	ErfK ybiS ycfS ynhG family protein
GH983_20090	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GH983_20100	COG1643	Atp-dependent helicase
GH983_20105	COG2423	ornithine cyclodeaminase activity
GH983_20145	COG3622	Belongs to the hyi family
GH983_20150	COG2084	Dehydrogenase
GH983_20155	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_20160	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_20165	COG1129	ABC transporter
GH983_20175	COG1609	Transcriptional regulator
GH983_20180	COG3395	kinase activity
GH983_20185	COG0235	Class ii aldolase
GH983_20190	COG0246	Mannitol dehydrogenase
GH983_20195	COG1312	Catalyzes the dehydration of D-mannonate
GH983_20200	COG1063	alcohol dehydrogenase
GH983_20205	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH983_20215	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_20220	COG2186	Transcriptional regulator
GH983_20230	COG2186	Transcriptional regulator
GH983_20235	COG1454	alcohol dehydrogenase
GH983_20240	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH983_20255	COG0747	negative chemotaxis
GH983_20260	COG0601	transmembrane transport
GH983_20270	COG4172	Belongs to the ABC transporter superfamily
GH983_20275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_20285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH983_20290	COG3842	ATPase activity
GH983_20300	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_20320	COG0477	Major facilitator Superfamily
GH983_20325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH983_20330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH983_20335	COG1845	cytochrome c oxidase, subunit III
GH983_20340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GH983_20360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_20380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GH983_20390	COG2986	histidine ammonia-lyase
GH983_20395	COG1228	amidohydrolase
GH983_20400	COG2986	histidine ammonia-lyase
GH983_20405	COG0402	S-adenosylhomocysteine deaminase activity
GH983_20410	COG1069	ribulokinase activity
GH983_20415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GH983_20435	COG0395	ABC-type sugar transport system, permease component
GH983_20440	COG1175	transmembrane transport
GH983_20450	COG2390	Transcriptional regulator
GH983_20465	COG3546	catalase activity
GH983_20475	COG1252	NADH dehydrogenase
GH983_20480	COG1120	ATPase activity
GH983_20490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH983_20505	COG3842	ATPase activity
GH983_20510	COG3842	ATPase activity
GH983_20520	COG0395	ABC-type sugar transport system, permease component
GH983_20540	COG1793	dna ligase
GH983_20555	COG3806	Anti-sigma factor
GH983_20560	COG1595	DNA-templated transcription, initiation
GH983_20575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH983_20580	COG4221	oxidoreductase activity
GH983_20585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH983_20595	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH983_20620	COG0539	negative regulation of cytoplasmic translation
GH983_20625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GH983_20660	COG2860	membrane
GH983_20670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH983_20680	COG2197	response regulator
GH983_20695	COG1185	polyribonucleotide nucleotidyltransferase activity
GH983_20700	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GH983_20705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GH983_20710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GH983_20715	COG3064	Membrane
GH983_20715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GH983_20725	COG0195	Participates in both transcription termination and antitermination
GH983_20725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH983_20730	COG0779	Required for maturation of 30S ribosomal subunits
GH983_20735	COG2814	Major facilitator Superfamily
GH983_20745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH983_20750	COG2258	MOSC domain
GH983_20760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GH983_20765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH983_20780	COG2816	NAD+ diphosphatase activity
GH983_20785	COG1605	Chorismate mutase
GH983_20785	COG0077	Prephenate dehydratase
GH983_20790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GH983_20795	COG3474	cytochrome
GH983_20805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH983_20830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH983_20840	COG2900	Belongs to the SlyX family
GH983_20855	COG0484	heat shock protein binding
GH983_20865	COG0443	Heat shock 70 kDa protein
GH983_20870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH983_20875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GH983_20890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH983_20890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH983_20900	COG0588	phosphoglycerate mutase activity
GH983_20905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH983_20910	COG1132	(ABC) transporter
GH983_20915	COG0837	glucose binding
GH983_20920	COG1803	Methylglyoxal synthase
GH983_20925	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GH983_20930	COG4166	transmembrane transport
GH983_20935	COG4174	ABC transporter (Permease)
GH983_20940	COG4239	(ABC) transporter, permease
GH983_20955	COG4172	Belongs to the ABC transporter superfamily
GH983_20970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GH983_21005	COG4964	Belongs to the GSP D family
GH983_21040	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GH983_21045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GH983_21050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GH983_21060	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GH983_21065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GH983_21100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH983_21115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH983_21115	COG0574	Belongs to the PEP-utilizing enzyme family
GH983_21120	COG1309	transcriptional regulator
GH983_21125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH983_21140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_21150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH983_21155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH983_21170	COG1126	abc transporter atp-binding protein
GH983_21175	COG0765	amino acid transport
GH983_21185	COG2186	Transcriptional regulator
GH983_21190	COG1363	Peptidase, m42
GH983_21215	COG0367	asparagine synthase
GH983_21220	COG2918	glutathione biosynthetic process
GH983_21220	COG0189	ligase activity
GH983_21235	COG3685	Protein conserved in bacteria
GH983_21260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH983_21270	COG0791	NLP P60 protein
GH983_21385	COG3422	double-strand break repair
GH983_21400	COG1733	regulation of RNA biosynthetic process
GH983_21405	COG0702	epimerase
GH983_21410	COG0481	GTPase activity
GH983_21415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_21435	COG4529	Protein conserved in bacteria
GH983_21445	COG1063	alcohol dehydrogenase
GH983_21450	COG0156	8-amino-7-oxononanoate synthase activity
GH983_21485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH983_21510	COG2271	Major facilitator Superfamily
GH983_21525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GH983_21540	COG0745	RESPONSE REGULATOR receiver
GH983_21545	COG2205	protein histidine kinase activity
GH983_21550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GH983_21555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GH983_21560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GH983_21580	COG0072	phenylalanine-tRNA ligase activity
GH983_21580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH983_21585	COG1162	GTPase activity
GH983_21610	COG1725	Transcriptional regulator
GH983_21615	COG0697	spore germination
GH983_21620	COG0667	Aldo Keto reductase
GH983_21625	COG0667	Aldo Keto reductase
GH983_21630	COG4977	sequence-specific DNA binding
GH983_21650	COG2076	Multidrug Resistance protein
GH983_21655	COG2226	methyltransferase
GH983_21655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH983_21655	COG0596	Alpha beta hydrolase
GH983_21670	COG1570	exodeoxyribonuclease VII activity
GH983_21675	COG2249	NAD(P)H dehydrogenase (quinone) activity
GH983_21680	COG1278	Cold shock
GH983_21705	COG2309	aminopeptidase activity
GH983_21710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GH983_21715	COG1393	Belongs to the ArsC family
GH983_21725	COG0300	oxidoreductase activity
GH983_21735	COG0519	Catalyzes the synthesis of GMP from XMP
GH983_21735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH983_21780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GH983_21790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH983_21800	COG1968	undecaprenyl-diphosphatase activity
GH983_21815	COG0284	orotidine-5'-phosphate decarboxylase activity
GH983_21820	COG3963	phosphatidate phosphatase activity
GH983_21825	COG0592	DNA-directed DNA polymerase activity
GH983_21830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GH983_21835	COG0792	nuclease activity
GH983_21840	COG1653	transport
GH983_21845	COG1175	transmembrane transport
GH983_21850	COG0395	ABC-type sugar transport system, permease component
GH983_21855	COG3842	ATPase activity
GH983_21860	COG0189	ligase activity
GH983_21870	COG3920	Histidine kinase
GH983_21880	COG1280	lysine exporter protein (LysE YggA)
GH983_21885	COG1280	lysine exporter protein (LysE YggA)
GH983_21900	COG1522	sequence-specific DNA binding
GH983_21910	COG0756	dUTP diphosphatase activity
GH983_21915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GH983_21935	COG1741	Belongs to the pirin family
GH983_21950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GH983_21955	COG3920	Histidine kinase
GH983_21960	COG3437	response regulator, receiver
GH983_21965	COG0784	Response regulator, receiver
GH983_21965	COG2198	Histidine kinase
GH983_21965	COG5002	protein histidine kinase activity
GH983_21970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH983_21975	COG2226	methyltransferase
GH983_21980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH983_21985	COG1024	Enoyl-CoA hydratase
GH983_21990	COG0268	Binds directly to 16S ribosomal RNA
GH983_22030	COG5002	protein histidine kinase activity
GH983_22040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GH983_22060	COG1285	pathogenesis
GH983_22130	COG4467	Involved in initiation control of chromosome replication
GH983_22185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GH983_22195	COG1431	PFAM Stem cell self-renewal protein Piwi
GH983_22200	COG1537	nuclear-transcribed mRNA catabolic process, no-go decay
GH983_22210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_22215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH983_22225	COG2814	Major facilitator Superfamily
GH983_22230	COG0583	DNA-binding transcription factor activity
GH983_22250	COG0625	glutathione transferase activity
GH983_22290	COG5507	3-demethylubiquinone-9 3-methyltransferase
GH983_22295	COG1473	amidohydrolase
GH983_22315	COG1473	amidohydrolase
GH983_22320	COG0156	8-amino-7-oxononanoate synthase activity
GH983_22375	COG1475	DNA binding
GH983_22400	COG5489	Protein of unknown function (DUF736)
GH983_22410	COG3831	ATPase activity
GH983_22420	COG3505	Type IV secretory pathway VirD4
GH983_22435	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH983_22440	COG4959	Type IV secretory pathway protease TraF
GH983_22445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_22465	COG1476	TRANSCRIPTIONal
GH983_22480	COG2948	multi-organism process
GH983_22490	COG3504	Conjugal transfer protein
GH983_22495	COG3701	Conjugal transfer protein
GH983_22500	COG3846	protein secretion by the type IV secretion system
GH983_22510	COG5314	conjugation
GH983_22515	COG3451	type IV secretory pathway VirB4
GH983_22520	COG5268	conjugation
GH983_22525	COG3838	Conjugal transfer protein Trbc
GH983_22530	COG4962	Type ii secretion system protein e
GH983_22535	COG3916	Acyl-homoserine-lactone synthase
GH983_22540	COG1192	Involved in chromosome partitioning
GH983_22545	COG1475	DNA binding
GH983_22550	COG0640	Transcriptional regulator
GH983_22565	COG0840	transmembrane signaling receptor activity
GH983_22570	COG2203	Gaf domain
GH983_22570	COG5001	Diguanylate cyclase
GH983_22570	COG4251	negative regulation of phosphorylation
GH983_22570	COG3706	GGDEF domain
GH983_22580	COG0640	Transcriptional regulator
GH983_22585	COG1278	Cold shock
GH983_22605	COG5001	Diguanylate cyclase
GH983_22605	COG3300	MHYT domain
GH983_22610	COG0406	alpha-ribazole phosphatase activity
GH983_22615	COG3842	ATPase activity
GH983_22635	COG1285	pathogenesis
GH983_22645	COG1215	transferase activity, transferring glycosyl groups
GH983_22665	COG0583	DNA-binding transcription factor activity
GH983_22680	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH983_22685	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GH983_22690	COG3842	ATPase activity
GH983_22705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_22760	COG1335	isochorismatase
GH983_22815	COG0745	RESPONSE REGULATOR receiver
GH983_22830	COG2948	multi-organism process
GH983_22840	COG3504	Conjugal transfer protein
GH983_22845	COG3701	Conjugal transfer protein
GH983_22850	COG3846	protein secretion by the type IV secretion system
GH983_22855	COG5314	conjugation
GH983_22860	COG3451	type IV secretory pathway VirB4
GH983_22865	COG5268	conjugation
GH983_22870	COG3838	Conjugal transfer protein Trbc
GH983_22875	COG4962	Type ii secretion system protein e
GH983_22885	COG1192	Involved in chromosome partitioning
GH983_22890	COG1475	DNA binding
GH983_22895	COG0640	Transcriptional regulator
GH983_22900	COG2972	Histidine kinase
GH983_22900	COG0840	transmembrane signaling receptor activity
GH983_22910	COG0840	transmembrane signaling receptor activity
GH983_22915	COG0840	transmembrane signaling receptor activity
GH983_22950	COG3177	Filamentation induced by cAMP protein fic
GH983_22965	COG3300	MHYT domain
GH983_22965	COG5001	Diguanylate cyclase
GH983_22975	COG3706	GGDEF domain
GH983_22980	COG1850	ribulose-bisphosphate carboxylase activity
GH983_22985	COG3958	Transketolase
GH983_22990	COG3959	Transketolase, thiamine diphosphate binding domain
GH983_22995	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GH983_23000	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GH983_23005	COG1129	ABC transporter
GH983_23010	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_23020	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_23020	COG3347	Dehydrogenase
GH983_23025	COG2390	Transcriptional regulator
GH983_23055	COG0402	S-adenosylhomocysteine deaminase activity
GH983_23070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH983_23140	COG3177	Filamentation induced by cAMP protein fic
GH983_23145	COG0583	DNA-binding transcription factor activity
GH983_23150	COG0625	glutathione transferase activity
GH983_23155	COG1017	nitric oxide dioxygenase activity
GH983_23155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH983_23160	COG0702	epimerase
GH983_23175	COG1505	serine-type exopeptidase activity
GH983_23185	COG5002	protein histidine kinase activity
GH983_23190	COG0745	RESPONSE REGULATOR receiver
GH983_23210	COG4221	oxidoreductase activity
GH983_23225	COG0667	Aldo Keto reductase
GH983_23235	COG2207	Transcriptional regulator
GH983_23250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH983_23260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH983_23260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH983_23265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_23280	COG1414	Transcriptional regulator
GH983_23285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GH983_23300	COG1802	Transcriptional regulator
GH983_23305	COG0129	dihydroxy-acid dehydratase activity
GH983_23310	COG1028	Short-chain dehydrogenase reductase Sdr
GH983_23315	COG1879	ABC-type sugar transport system periplasmic component
GH983_23320	COG1129	ABC transporter
GH983_23325	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_23330	COG1012	belongs to the aldehyde dehydrogenase family
GH983_23350	COG1396	sequence-specific DNA binding
GH983_23355	COG3550	peptidyl-serine autophosphorylation
GH983_23365	COG1063	alcohol dehydrogenase
GH983_23370	COG3284	Transcriptional regulator
GH983_23375	COG0583	DNA-binding transcription factor activity
GH983_23380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GH983_23385	COG0511	ligase activity, forming carbon-carbon bonds
GH983_23390	COG0439	Biotin carboxylase
GH983_23400	COG1984	allophanate hydrolase subunit 2
GH983_23405	COG1879	ABC-type sugar transport system periplasmic component
GH983_23410	COG1129	ABC transporter
GH983_23415	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_23435	COG4227	nucleotidyltransferase activity
GH983_23440	COG3550	peptidyl-serine autophosphorylation
GH983_23480	COG1278	Cold shock
GH983_23490	COG3620	sequence-specific DNA binding
GH983_23495	COG0210	DNA helicase
GH983_23505	COG0583	DNA-binding transcription factor activity
GH983_23550	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GH983_23570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GH983_23575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GH983_23580	COG0367	asparagine synthase
GH983_23585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH983_23585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_23605	COG1132	(ABC) transporter
GH983_23620	COG2264	protein methyltransferase activity
GH983_23650	COG0367	asparagine synthase
GH983_23685	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GH983_23695	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GH983_23700	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GH983_23700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH983_23730	COG0667	Aldo Keto reductase
GH983_23755	COG1129	ABC transporter
GH983_23760	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH983_23765	COG2376	Dihydroxyacetone kinase
GH983_23775	COG1069	ribulokinase activity
GH983_23785	COG4948	Mandelate Racemase Muconate Lactonizing
GH983_23795	COG1012	belongs to the aldehyde dehydrogenase family
GH983_23805	COG5002	protein histidine kinase activity
GH983_23810	COG1609	Transcriptional regulator
GH983_23830	COG3842	ATPase activity
GH983_23840	COG2963	transposase activity
GH983_23870	COG1396	sequence-specific DNA binding
GH983_23875	COG3706	GGDEF domain
GH983_23880	COG2801	Transposase and inactivated derivatives
GH983_23890	COG5489	Protein of unknown function (DUF736)
GH983_23895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GH983_23910	COG3831	ATPase activity
GH983_23915	COG3505	Type IV secretory pathway VirD4
GH983_23930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH983_23935	COG4959	Type IV secretory pathway protease TraF
GH983_23940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH983_23955	COG1968	undecaprenyl-diphosphatase activity
GH983_23965	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH983_24010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GH983_24015	COG0489	protein tyrosine kinase activity
GH983_24020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GH983_24025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH983_24040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GH983_24045	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine