locus-tag	class	description
IAI05_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAI05_00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IAI05_00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IAI05_00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IAI05_00025	COG1420	regulation of RNA biosynthetic process
IAI05_00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAI05_00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAI05_00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IAI05_00050	COG1137	ATPase activity
IAI05_00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IAI05_00065	COG0616	signal peptide processing
IAI05_00070	COG0776	regulation of translation
IAI05_00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IAI05_00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAI05_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IAI05_00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IAI05_00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IAI05_00115	COG0728	peptidoglycan biosynthetic process
IAI05_00125	COG0180	Tryptophanyl-tRNA synthetase
IAI05_00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IAI05_00140	COG1214	PFAM Peptidase M22, glycoprotease
IAI05_00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAI05_00165	COG1702	phosphate starvation-inducible protein PhoH
IAI05_00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IAI05_00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IAI05_00185	COG1396	sequence-specific DNA binding
IAI05_00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAI05_00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IAI05_00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_00210	COG0242	peptide deformylase activity
IAI05_00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAI05_00220	COG0101	tRNA pseudouridine synthase activity
IAI05_00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAI05_00235	COG2171	N-acyltransferase activity
IAI05_00245	COG0840	transmembrane signaling receptor activity
IAI05_00250	COG1957	nucleoside hydrolase
IAI05_00255	COG0071	Belongs to the small heat shock protein (HSP20) family
IAI05_00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAI05_00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IAI05_00295	COG0706	membrane insertase activity
IAI05_00300	COG0594	ribonuclease P activity
IAI05_00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IAI05_00310	COG0840	transmembrane signaling receptor activity
IAI05_00325	COG2226	methyltransferase
IAI05_00330	COG3842	ATPase activity
IAI05_00335	COG1175	transmembrane transport
IAI05_00340	COG0395	ABC-type sugar transport system, permease component
IAI05_00355	COG0427	acetyl-CoA hydrolase
IAI05_00365	COG3938	Belongs to the proline racemase family
IAI05_00370	COG0418	dihydroorotase activity
IAI05_00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAI05_00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAI05_00400	COG0166	Belongs to the GPI family
IAI05_00405	COG0318	PFAM AMP-dependent synthetase and ligase
IAI05_00410	COG3842	ATPase activity
IAI05_00415	COG1840	ABC-type Fe3 transport system, periplasmic component
IAI05_00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IAI05_00425	COG4774	siderophore transport
IAI05_00470	COG2326	polyphosphate kinase activity
IAI05_00475	COG5002	protein histidine kinase activity
IAI05_00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAI05_00485	COG0573	inorganic phosphate transmembrane transporter activity
IAI05_00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAI05_00500	COG0704	Plays a role in the regulation of phosphate uptake
IAI05_00505	COG0745	RESPONSE REGULATOR receiver
IAI05_00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAI05_00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAI05_00530	COG2967	ApaG domain
IAI05_00540	COG0717	Belongs to the dCTP deaminase family
IAI05_00550	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IAI05_00555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAI05_00605	COG0167	dihydroorotate dehydrogenase activity
IAI05_00640	COG1959	2 iron, 2 sulfur cluster binding
IAI05_00645	COG1201	RNA secondary structure unwinding
IAI05_00675	COG1960	acyl-CoA dehydrogenase activity
IAI05_00680	COG0183	Belongs to the thiolase family
IAI05_00685	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAI05_00685	COG1024	Enoyl-CoA hydratase
IAI05_00705	COG1320	monovalent cation:proton antiporter activity
IAI05_00710	COG2212	antiporter activity
IAI05_00715	COG1863	multisubunit Na H antiporter MnhE subunit
IAI05_00720	COG0651	ATP synthesis coupled electron transport
IAI05_00725	COG1006	Multisubunit Na H antiporter MnhC subunit
IAI05_00730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAI05_00730	COG2111	Na H antiporter
IAI05_00740	COG0840	transmembrane signaling receptor activity
IAI05_00750	COG0745	RESPONSE REGULATOR receiver
IAI05_00755	COG2198	Histidine kinase
IAI05_00755	COG0643	Histidine kinase
IAI05_00760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IAI05_00765	COG2201	protein-glutamate methylesterase activity
IAI05_00770	COG0745	RESPONSE REGULATOR receiver
IAI05_00775	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IAI05_00785	COG1766	The M ring may be actively involved in energy transduction
IAI05_00790	COG2771	luxR family
IAI05_00800	COG2972	Histidine kinase
IAI05_00800	COG0840	transmembrane signaling receptor activity
IAI05_00805	COG0784	Response regulator, receiver
IAI05_00805	COG2198	Histidine kinase
IAI05_00805	COG2205	protein histidine kinase activity
IAI05_00810	COG1970	mechanosensitive ion channel activity
IAI05_00815	COG0436	Aminotransferase
IAI05_00830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IAI05_00835	COG0424	maF-like protein
IAI05_00840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAI05_00850	COG5328	Belongs to the UPF0262 family
IAI05_00855	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IAI05_00865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAI05_00885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IAI05_00895	COG1338	Plays a role in the flagellum-specific transport system
IAI05_00905	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IAI05_00915	COG1706	bacterial-type flagellum-dependent cell motility
IAI05_00920	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
IAI05_00925	COG4786	Flagellar basal body rod
IAI05_00930	COG1677	Flagellar hook-basal body complex protein FliE
IAI05_00935	COG1558	bacterial-type flagellum-dependent cell motility
IAI05_00940	COG1815	bacterial-type flagellum-dependent cell motility
IAI05_00950	COG1157	protein secretion by the type III secretion system
IAI05_00955	COG4786	Flagellar basal body rod
IAI05_00965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IAI05_00970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IAI05_00975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IAI05_00980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IAI05_00985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IAI05_01005	COG1360	Flagellar Motor Protein
IAI05_01030	COG1749	Flagellar hook protein flgE
IAI05_01050	COG5443	negative regulation of bacterial-type flagellum assembly
IAI05_01055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IAI05_01065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IAI05_01105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAI05_01110	COG1609	Transcriptional regulator
IAI05_01115	COG1653	transport
IAI05_01120	COG1175	transmembrane transport
IAI05_01125	COG0395	ABC-type sugar transport system, permease component
IAI05_01130	COG0366	Alpha amylase catalytic
IAI05_01135	COG3842	ATPase activity
IAI05_01150	COG0129	dihydroxy-acid dehydratase activity
IAI05_01155	COG0363	glucosamine-6-phosphate deaminase activity
IAI05_01160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IAI05_01165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_01175	COG2081	HI0933 family
IAI05_01195	COG2224	Isocitrate lyase
IAI05_01210	COG3842	ATPase activity
IAI05_01215	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAI05_01220	COG1177	transmembrane transport
IAI05_01230	COG2205	protein histidine kinase activity
IAI05_01240	COG0248	Ppx GppA phosphatase
IAI05_01245	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IAI05_01250	COG0477	Major facilitator Superfamily
IAI05_01280	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAI05_01285	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAI05_01295	COG0142	geranyltranstransferase activity
IAI05_01320	COG0752	glycyl-tRNA synthetase alpha subunit
IAI05_01330	COG1704	LemA family
IAI05_01335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IAI05_01345	COG0751	glycine-tRNA ligase activity
IAI05_01350	COG1683	Conserved Protein
IAI05_01355	COG0840	transmembrane signaling receptor activity
IAI05_01365	COG0151	Belongs to the GarS family
IAI05_01370	COG2183	response to ionizing radiation
IAI05_01375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAI05_01400	COG0583	DNA-binding transcription factor activity
IAI05_01420	COG0306	phosphate transporter
IAI05_01430	COG0561	phosphatase activity
IAI05_01435	COG0438	transferase activity, transferring glycosyl groups
IAI05_01440	COG2186	Transcriptional regulator
IAI05_01450	COG0583	DNA-binding transcription factor activity
IAI05_01455	COG0277	FAD linked oxidase domain protein
IAI05_01460	COG0277	FAD linked oxidase domain protein
IAI05_01465	COG0247	lactate metabolic process
IAI05_01475	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_01480	COG2818	Glycosylase
IAI05_01490	COG2855	membrane
IAI05_01495	COG0583	DNA-binding transcription factor activity
IAI05_01525	COG0124	histidyl-tRNA synthetase
IAI05_01535	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IAI05_01540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IAI05_01545	COG2259	Doxx family
IAI05_01555	COG0459	protein refolding
IAI05_01560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IAI05_01570	COG0196	riboflavin kinase activity
IAI05_01575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IAI05_01585	COG0590	tRNA wobble adenosine to inosine editing
IAI05_01590	COG1187	pseudouridine synthase activity
IAI05_01595	COG0742	ribosomal rna small subunit methyltransferase
IAI05_01600	COG1752	Esterase of the alpha-beta hydrolase superfamily
IAI05_01610	COG0312	modulator of DNA gyrase
IAI05_01615	COG0483	inositol monophosphate 1-phosphatase activity
IAI05_01625	COG1519	Transferase
IAI05_01635	COG1663	tetraacyldisaccharide 4'-kinase activity
IAI05_01645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAI05_01650	COG0745	RESPONSE REGULATOR receiver
IAI05_01655	COG3300	MHYT domain
IAI05_01655	COG5001	Diguanylate cyclase
IAI05_01660	COG3386	PFAM SMP-30 Gluconolaconase
IAI05_01665	COG0800	Aldolase
IAI05_01670	COG3734	2-keto-3-deoxy-galactonokinase
IAI05_01675	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_01680	COG1414	Transcriptional regulator
IAI05_01685	COG2197	response regulator
IAI05_01700	COG0598	Magnesium transport protein CorA
IAI05_01705	COG3158	transport of potassium into the cell
IAI05_01720	COG0356	it plays a direct role in the translocation of protons across the membrane
IAI05_01730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IAI05_01735	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IAI05_01750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAI05_01770	COG0009	L-threonylcarbamoyladenylate synthase
IAI05_01780	COG4638	Rieske (2fe-2S)
IAI05_01805	COG1960	acyl-CoA dehydrogenase activity
IAI05_01820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IAI05_01825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IAI05_01830	COG0840	transmembrane signaling receptor activity
IAI05_01840	COG1522	sequence-specific DNA binding
IAI05_01865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAI05_01870	COG1741	Belongs to the pirin family
IAI05_01875	COG1722	exodeoxyribonuclease VII activity
IAI05_01880	COG0123	including yeast histone deacetylase and acetoin utilization protein
IAI05_01885	COG1268	BioY protein
IAI05_01890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IAI05_01895	COG1122	ATPase activity
IAI05_01900	COG3214	Protein conserved in bacteria
IAI05_01905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAI05_01905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAI05_01910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IAI05_01930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAI05_01945	COG0259	pyridoxamine-phosphate oxidase activity
IAI05_01975	COG0312	modulator of DNA gyrase
IAI05_01990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAI05_01995	COG0109	protoheme IX farnesyltransferase activity
IAI05_02000	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IAI05_02015	COG3346	SURF1 family
IAI05_02020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAI05_02025	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IAI05_02030	COG0328	RNA-DNA hybrid ribonuclease activity
IAI05_02040	COG0678	peroxiredoxin activity
IAI05_02040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IAI05_02050	COG1678	Uncharacterized ACR, COG1678
IAI05_02055	COG3237	CsbD-like
IAI05_02065	COG5001	Diguanylate cyclase
IAI05_02065	COG3300	MHYT domain
IAI05_02070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAI05_02075	COG0612	Peptidase, M16
IAI05_02100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAI05_02105	COG1802	Transcriptional regulator
IAI05_02125	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IAI05_02130	COG3609	addiction module antidote protein, CC2985 family
IAI05_02135	COG3668	Plasmid stabilization system
IAI05_02145	COG1194	a g-specific adenine glycosylase
IAI05_02160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IAI05_02165	COG1196	nuclear chromosome segregation
IAI05_02170	COG2514	catechol 2,3-dioxygenase activity
IAI05_02175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAI05_02175	COG0574	Belongs to the PEP-utilizing enzyme family
IAI05_02190	COG1823	symporter activity
IAI05_02215	COG0579	oxidoreductase
IAI05_02230	COG2895	sulfate adenylyltransferase (ATP) activity
IAI05_02235	COG0175	sulfate reduction
IAI05_02240	COG0175	sulfate reduction
IAI05_02245	COG1959	2 iron, 2 sulfur cluster binding
IAI05_02250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IAI05_02255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IAI05_02260	COG4208	sulfate ABC transporter
IAI05_02265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAI05_02290	COG2203	Gaf domain
IAI05_02290	COG2199	diguanylate cyclase activity
IAI05_02290	COG2200	EAL domain
IAI05_02300	COG1309	transcriptional regulator
IAI05_02305	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_02310	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IAI05_02340	COG0625	glutathione transferase activity
IAI05_02350	COG0477	Major facilitator Superfamily
IAI05_02365	COG1793	dna ligase
IAI05_02365	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IAI05_02385	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_02390	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_02395	COG1846	Transcriptional regulator
IAI05_02400	COG1764	response to oxidative stress
IAI05_02415	COG0488	(ABC) transporter
IAI05_02450	COG4221	oxidoreductase activity
IAI05_02465	COG0433	COG0433 Predicted ATPase
IAI05_02475	COG1733	regulation of RNA biosynthetic process
IAI05_02480	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IAI05_02495	COG0656	L-ascorbic acid biosynthetic process
IAI05_02500	COG3781	membrane
IAI05_02515	COG4106	trans-aconitate 2-methyltransferase activity
IAI05_02520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAI05_02525	COG0840	transmembrane signaling receptor activity
IAI05_02530	COG0583	DNA-binding transcription factor activity
IAI05_02545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAI05_02565	COG3909	cytochrome
IAI05_02570	COG2010	Cytochrome c
IAI05_02600	COG0789	Transcriptional regulator
IAI05_02625	COG4175	Glycine betaine
IAI05_02625	COG0517	IMP dehydrogenase activity
IAI05_02630	COG4176	ABC-type proline glycine betaine transport system permease component
IAI05_02650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_02660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAI05_02660	COG2169	Transcriptional regulator
IAI05_02670	COG2514	catechol 2,3-dioxygenase activity
IAI05_02685	COG1272	protein, Hemolysin III
IAI05_02695	COG1280	lysine exporter protein (LysE YggA)
IAI05_02700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAI05_02705	COG2111	Na H antiporter
IAI05_02705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAI05_02710	COG2111	Na H antiporter
IAI05_02715	COG1006	Multisubunit Na H antiporter MnhC subunit
IAI05_02720	COG0651	ATP synthesis coupled electron transport
IAI05_02725	COG1863	multisubunit Na H antiporter MnhE subunit
IAI05_02730	COG2212	antiporter activity
IAI05_02735	COG1320	monovalent cation:proton antiporter activity
IAI05_02740	COG4957	zinc ion binding
IAI05_02755	COG2166	iron-sulfur cluster assembly
IAI05_02765	COG2205	protein histidine kinase activity
IAI05_02810	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAI05_02815	COG2983	Belongs to the UPF0260 family
IAI05_02860	COG2814	Major facilitator Superfamily
IAI05_02870	COG1621	beta-fructofuranosidase activity
IAI05_02875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IAI05_02925	COG4695	Portal protein
IAI05_03030	COG4235	cytochrome complex assembly
IAI05_03035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IAI05_03040	COG1138	Cytochrome C-type biogenesis protein
IAI05_03045	COG3088	subunit of a heme lyase
IAI05_03050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAI05_03055	COG0745	RESPONSE REGULATOR receiver
IAI05_03060	COG2205	protein histidine kinase activity
IAI05_03065	COG3011	Protein conserved in bacteria
IAI05_03070	COG3713	MltA-interacting MipA family protein
IAI05_03075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IAI05_03080	COG2202	Pas domain
IAI05_03080	COG2205	protein histidine kinase activity
IAI05_03090	COG0308	aminopeptidase N
IAI05_03095	COG0697	spore germination
IAI05_03110	COG0443	Heat shock 70 kDa protein
IAI05_03150	COG0604	alcohol dehydrogenase
IAI05_03155	COG1733	regulation of RNA biosynthetic process
IAI05_03160	COG1968	undecaprenyl-diphosphatase activity
IAI05_03165	COG2239	Acts as a magnesium transporter
IAI05_03170	COG2814	Major facilitator Superfamily
IAI05_03195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IAI05_03225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAI05_03270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IAI05_03275	COG0741	lytic transglycosylase activity
IAI05_03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_03285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IAI05_03290	COG0840	transmembrane signaling receptor activity
IAI05_03300	COG1758	RNA polymerase activity
IAI05_03320	COG0736	holo-[acyl-carrier-protein] synthase activity
IAI05_03325	COG0681	Belongs to the peptidase S26 family
IAI05_03330	COG0571	ribonuclease III activity
IAI05_03335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAI05_03345	COG0784	Response regulator, receiver
IAI05_03350	COG1381	Involved in DNA repair and RecF pathway recombination
IAI05_03360	COG2226	methyltransferase
IAI05_03370	COG1418	mRNA catabolic process
IAI05_03380	COG0346	lactoylglutathione lyase activity
IAI05_03395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_03400	COG3443	Belongs to the bacterial solute-binding protein 9 family
IAI05_03405	COG0668	transmembrane transport
IAI05_03415	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IAI05_03445	COG1742	UPF0060 membrane protein
IAI05_03460	COG1183	phosphatidylcholine synthase activity
IAI05_03465	COG0688	phosphatidylethanolamine metabolic process
IAI05_03470	COG5265	(ABC) transporter
IAI05_03510	COG2852	Protein conserved in bacteria
IAI05_03515	COG0215	cysteine-tRNA ligase activity
IAI05_03520	COG4221	oxidoreductase activity
IAI05_03525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IAI05_03530	COG1286	toxin biosynthetic process
IAI05_03550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAI05_03560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IAI05_03570	COG0305	Participates in initiation and elongation during chromosome replication
IAI05_03590	COG0359	binds to the 23S rRNA
IAI05_03600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAI05_03605	COG0360	Binds together with S18 to 16S ribosomal RNA
IAI05_03615	COG0667	Aldo Keto reductase
IAI05_03620	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IAI05_03630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAI05_03635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAI05_03640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IAI05_03645	COG1561	YicC-like family, N-terminal region
IAI05_03650	COG0194	GDP metabolic process
IAI05_03665	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAI05_03670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IAI05_03680	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IAI05_03695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAI05_03715	COG3706	GGDEF domain
IAI05_03715	COG2203	Gaf domain
IAI05_03715	COG4251	negative regulation of phosphorylation
IAI05_03715	COG5001	Diguanylate cyclase
IAI05_03720	COG5001	Diguanylate cyclase
IAI05_03720	COG3300	MHYT domain
IAI05_03725	COG4191	Histidine kinase
IAI05_03730	COG4566	intracellular signal transduction
IAI05_03740	COG0488	(ABC) transporter
IAI05_03745	COG3706	GGDEF domain
IAI05_03755	COG0105	UTP biosynthetic process
IAI05_03775	COG0314	molybdopterin synthase activity
IAI05_03785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IAI05_03790	COG0322	excinuclease ABC activity
IAI05_03795	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_03805	COG0625	glutathione transferase activity
IAI05_03820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IAI05_03825	COG0243	molybdopterin cofactor binding
IAI05_03840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IAI05_03845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IAI05_03855	COG0628	permease
IAI05_03865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IAI05_03870	COG0248	Ppx GppA phosphatase
IAI05_03895	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IAI05_03905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IAI05_03910	COG0477	Major facilitator Superfamily
IAI05_03915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAI05_03925	COG0840	transmembrane signaling receptor activity
IAI05_03930	COG0659	secondary active sulfate transmembrane transporter activity
IAI05_03940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAI05_03945	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IAI05_03955	COG0113	porphobilinogen synthase activity
IAI05_03975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAI05_03980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAI05_03985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAI05_03985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAI05_03995	COG1280	lysine exporter protein (LysE YggA)
IAI05_04000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IAI05_04005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAI05_04010	COG2814	Major facilitator Superfamily
IAI05_04015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IAI05_04035	COG0416	fatty acid biosynthetic process
IAI05_04040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAI05_04045	COG0776	regulation of translation
IAI05_04080	COG0601	transmembrane transport
IAI05_04085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_04090	COG0444	Belongs to the ABC transporter superfamily
IAI05_04100	COG0747	negative chemotaxis
IAI05_04110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IAI05_04115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IAI05_04130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAI05_04135	COG0583	DNA-binding transcription factor activity
IAI05_04140	COG0737	Belongs to the 5'-nucleotidase family
IAI05_04160	COG2897	thiosulfate sulfurtransferase activity
IAI05_04175	COG0415	Belongs to the DNA photolyase family
IAI05_04185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAI05_04215	COG3932	Exopolysaccharide synthesis, ExoD
IAI05_04220	COG1238	metal cluster binding
IAI05_04295	COG1612	heme a metabolic process
IAI05_04305	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAI05_04310	COG0010	Belongs to the arginase family
IAI05_04315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IAI05_04320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAI05_04330	COG1832	CoA-binding protein
IAI05_04355	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_04360	COG2124	cytochrome p450
IAI05_04365	COG2199	diguanylate cyclase activity
IAI05_04370	COG0740	serine-type endopeptidase activity
IAI05_04375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IAI05_04380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IAI05_04390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IAI05_04415	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAI05_04420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAI05_04425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAI05_04435	COG0649	NAD binding
IAI05_04445	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IAI05_04450	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IAI05_04460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IAI05_04465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IAI05_04475	COG0713	ATP synthesis coupled electron transport
IAI05_04490	COG1007	ATP synthesis coupled electron transport
IAI05_04495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IAI05_04495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IAI05_04510	COG0442	prolyl-tRNA aminoacylation
IAI05_04520	COG1136	(ABC) transporter
IAI05_04535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAI05_04555	COG0784	Response regulator, receiver
IAI05_04565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAI05_04570	COG0477	Major facilitator Superfamily
IAI05_04585	COG0557	exoribonuclease II activity
IAI05_04590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAI05_04600	COG0758	DNA mediated transformation
IAI05_04605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IAI05_04615	COG0540	Belongs to the ATCase OTCase family
IAI05_04630	COG1960	acyl-CoA dehydrogenase activity
IAI05_04635	COG0456	acetyltransferase
IAI05_04655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAI05_04660	COG2824	Alkylphosphonate utilization operon protein PhnA
IAI05_04665	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAI05_04670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAI05_04675	COG0154	amidase activity
IAI05_04680	COG0456	acetyltransferase
IAI05_04685	COG3811	Belongs to the UPF0386 family
IAI05_04700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAI05_04710	COG0456	acetyltransferase
IAI05_04730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IAI05_04735	COG0439	Biotin carboxylase
IAI05_04740	COG0511	ligase activity, forming carbon-carbon bonds
IAI05_04745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IAI05_04755	COG0436	Aminotransferase
IAI05_04775	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_04780	COG1530	ribonuclease E activity
IAI05_04790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAI05_04810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IAI05_04815	COG0384	phenazine biosynthesis protein PhzF
IAI05_04835	COG0633	Ferredoxin
IAI05_04845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IAI05_04850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IAI05_04855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IAI05_04865	COG3768	UPF0283 membrane protein
IAI05_04870	COG3106	COG3106 Predicted ATPase
IAI05_04900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IAI05_04930	COG0537	adenosine 5'-monophosphoramidase activity
IAI05_04955	COG0052	Belongs to the universal ribosomal protein uS2 family
IAI05_04960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IAI05_04965	COG0528	UMP kinase activity
IAI05_04970	COG0233	cytoplasmic translational termination
IAI05_04975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAI05_04985	COG0750	zinc metalloprotease
IAI05_04990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAI05_04995	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IAI05_05000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAI05_05005	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IAI05_05010	COG3494	Protein of unknown function (DUF1009)
IAI05_05015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IAI05_05020	COG2186	Transcriptional regulator
IAI05_05030	COG0765	amino acid transport
IAI05_05035	COG0765	amino acid transport
IAI05_05045	COG0372	Belongs to the citrate synthase family
IAI05_05060	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IAI05_05070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IAI05_05075	COG0148	phosphopyruvate hydratase activity
IAI05_05085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IAI05_05090	COG0022	dehydrogenase e1 component
IAI05_05090	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAI05_05095	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAI05_05105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAI05_05115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IAI05_05120	COG0697	spore germination
IAI05_05140	COG2867	negative regulation of translational initiation
IAI05_05145	COG1546	Belongs to the CinA family
IAI05_05150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAI05_05150	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IAI05_05160	COG3852	Histidine kinase
IAI05_05165	COG2204	response regulator
IAI05_05170	COG5000	phosphorelay sensor kinase activity
IAI05_05175	COG2204	response regulator
IAI05_05180	COG0569	domain protein
IAI05_05185	COG1923	regulation of RNA biosynthetic process
IAI05_05190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAI05_05195	COG3956	TIGRFAM MazG family protein
IAI05_05205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAI05_05205	COG1648	precorrin-2 dehydrogenase activity
IAI05_05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAI05_05245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAI05_05250	COG0509	glycine decarboxylation via glycine cleavage system
IAI05_05255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAI05_05280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAI05_05285	COG0564	pseudouridine synthase activity
IAI05_05305	COG0251	oxidation-reduction process
IAI05_05310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IAI05_05320	COG1671	Belongs to the UPF0178 family
IAI05_05335	COG0450	alkyl hydroperoxide reductase
IAI05_05345	COG0625	glutathione transferase activity
IAI05_05370	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAI05_05385	COG0436	Aminotransferase
IAI05_05405	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_05410	COG3836	Belongs to the HpcH HpaI aldolase family
IAI05_05425	COG0431	NADPH-dependent FMN reductase
IAI05_05435	COG0798	PFAM Bile acid sodium symporter
IAI05_05455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IAI05_05455	COG0321	lipoyl(octanoyl) transferase activity
IAI05_05460	COG0084	hydrolase, TatD family'
IAI05_05465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAI05_05475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IAI05_05530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAI05_05535	COG2095	MarC family integral membrane protein
IAI05_05540	COG0617	tRNA 3'-terminal CCA addition
IAI05_05540	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IAI05_05540	COG0517	IMP dehydrogenase activity
IAI05_05550	COG0629	single-stranded DNA binding
IAI05_05555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAI05_05565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IAI05_05595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAI05_05600	COG1121	(ABC) transporter
IAI05_05620	COG0667	Aldo Keto reductase
IAI05_05630	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IAI05_05710	COG2239	Acts as a magnesium transporter
IAI05_05715	COG0243	molybdopterin cofactor binding
IAI05_05725	COG0242	peptide deformylase activity
IAI05_05740	COG2205	protein histidine kinase activity
IAI05_05740	COG2202	Pas domain
IAI05_05750	COG0321	lipoyl(octanoyl) transferase activity
IAI05_05755	COG1064	alcohol dehydrogenase
IAI05_05785	COG1862	Preprotein translocase
IAI05_05805	COG2124	cytochrome p450
IAI05_05820	COG0596	Alpha beta hydrolase
IAI05_05830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAI05_05835	COG0626	cystathionine gamma-synthase activity
IAI05_05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_05845	COG4597	amino acid ABC transporter
IAI05_05850	COG0765	amino acid transport
IAI05_05855	COG1126	abc transporter atp-binding protein
IAI05_05870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IAI05_05885	COG0436	Aminotransferase
IAI05_05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAI05_05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAI05_05930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAI05_05935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IAI05_05950	COG3243	poly(R)-hydroxyalkanoic acid synthase
IAI05_05955	COG1489	DNA binding
IAI05_05960	COG0024	Methionine aminopeptidase
IAI05_05965	COG2003	Belongs to the UPF0758 family
IAI05_05980	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IAI05_06005	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IAI05_06010	COG0546	phosphoglycolate phosphatase activity
IAI05_06020	COG0114	fumarate hydratase activity
IAI05_06030	COG0504	CTP synthase activity
IAI05_06040	COG0149	triose-phosphate isomerase activity
IAI05_06050	COG0187	DNA topoisomerase II activity
IAI05_06060	COG0740	serine-type endopeptidase activity
IAI05_06070	COG0640	Transcriptional regulator
IAI05_06075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAI05_06080	COG0745	RESPONSE REGULATOR receiver
IAI05_06100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IAI05_06100	COG3264	Mechanosensitive ion channel
IAI05_06165	COG1127	ABC transporter
IAI05_06170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IAI05_06175	COG4948	Mandelate Racemase Muconate Lactonizing
IAI05_06185	COG0281	malic enzyme
IAI05_06185	COG0280	phosphate acetyltransferase
IAI05_06195	COG0778	Nitroreductase
IAI05_06200	COG0823	Involved in the tonB-independent uptake of proteins
IAI05_06215	COG1368	sulfuric ester hydrolase activity
IAI05_06240	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAI05_06260	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IAI05_06280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IAI05_06295	COG0318	PFAM AMP-dependent synthetase and ligase
IAI05_06305	COG0512	Glutamine amidotransferase of anthranilate synthase
IAI05_06305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAI05_06310	COG0343	queuine tRNA-ribosyltransferase activity
IAI05_06315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAI05_06330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IAI05_06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAI05_06350	COG0134	indole-3-glycerol-phosphate synthase activity
IAI05_06355	COG0315	cyclic pyranopterin monophosphate synthase activity
IAI05_06360	COG0303	'Molybdopterin
IAI05_06365	COG3706	GGDEF domain
IAI05_06375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IAI05_06375	COG0475	glutathione-regulated potassium exporter activity
IAI05_06385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAI05_06395	COG2814	Major facilitator Superfamily
IAI05_06400	COG0746	molybdenum cofactor guanylyltransferase activity
IAI05_06405	COG1763	Mo-molybdopterin cofactor biosynthetic process
IAI05_06410	COG0739	heme binding
IAI05_06415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IAI05_06420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IAI05_06425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAI05_06430	COG0805	protein transport
IAI05_06435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAI05_06440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAI05_06445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAI05_06450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAI05_06455	COG1472	Belongs to the glycosyl hydrolase 3 family
IAI05_06465	COG0018	arginyl-trna synthetase
IAI05_06470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IAI05_06495	COG0525	valine-tRNA ligase activity
IAI05_06505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IAI05_06535	COG0655	NAD(P)H dehydrogenase (quinone) activity
IAI05_06540	COG1058	Belongs to the CinA family
IAI05_06540	COG1546	Belongs to the CinA family
IAI05_06545	COG0589	response to stress
IAI05_06550	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IAI05_06555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAI05_06565	COG0640	Transcriptional regulator
IAI05_06570	COG1914	H( )-stimulated, divalent metal cation uptake system
IAI05_06580	COG1132	(ABC) transporter
IAI05_06585	COG0628	permease
IAI05_06620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IAI05_06630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IAI05_06640	COG0302	gtp cyclohydrolase
IAI05_06645	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IAI05_06650	COG1752	Esterase of the alpha-beta hydrolase superfamily
IAI05_06660	COG0517	IMP dehydrogenase activity
IAI05_06660	COG0516	GMP reductase activity
IAI05_06695	COG1760	l-serine dehydratase
IAI05_06720	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAI05_06730	COG0583	DNA-binding transcription factor activity
IAI05_06745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAI05_06745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IAI05_06755	COG0347	Belongs to the P(II) protein family
IAI05_06760	COG0174	glutamine synthetase
IAI05_06790	COG0697	spore germination
IAI05_06800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IAI05_06810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IAI05_06840	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAI05_06845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAI05_06850	COG2186	Transcriptional regulator
IAI05_06860	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAI05_06865	COG4603	Belongs to the binding-protein-dependent transport system permease family
IAI05_06870	COG3845	ABC transporter
IAI05_06875	COG1183	phosphatidylcholine synthase activity
IAI05_06880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAI05_06885	COG0679	Auxin Efflux Carrier
IAI05_06890	COG0785	Cytochrome C biogenesis protein
IAI05_06920	COG1278	Cold shock
IAI05_07115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAI05_07205	COG0629	single-stranded DNA binding
IAI05_07370	COG0433	COG0433 Predicted ATPase
IAI05_07475	COG1475	DNA binding
IAI05_07495	COG3750	Belongs to the UPF0335 family
IAI05_07690	COG0582	viral genome integration into host DNA
IAI05_07710	COG0577	efflux transmembrane transporter activity
IAI05_07710	COG1136	(ABC) transporter
IAI05_07715	COG0577	efflux transmembrane transporter activity
IAI05_07715	COG1136	(ABC) transporter
IAI05_07740	COG2151	metal-sulfur cluster biosynthetic enzyme
IAI05_07745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAI05_07750	COG0719	Fe-S assembly protein
IAI05_07755	COG0396	ATPase activity
IAI05_07760	COG0719	Fe-S assembly protein
IAI05_07765	COG1104	cysteine desulfurase activity
IAI05_07770	COG2945	thiolester hydrolase activity
IAI05_07775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IAI05_07780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IAI05_07790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IAI05_07795	COG2833	Protein of unknown function (DUF455)
IAI05_07800	COG0739	heme binding
IAI05_07805	COG0513	Belongs to the DEAD box helicase family
IAI05_07830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAI05_07840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAI05_07845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAI05_07850	COG0047	phosphoribosylformylglycinamidine synthase activity
IAI05_07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAI05_07870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAI05_07895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IAI05_07900	COG2814	Major facilitator Superfamily
IAI05_07905	COG0483	inositol monophosphate 1-phosphatase activity
IAI05_07910	COG0483	inositol monophosphate 1-phosphatase activity
IAI05_07915	COG0037	tRNA processing
IAI05_07920	COG2066	Belongs to the glutaminase family
IAI05_07925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAI05_07930	COG0861	Integral membrane protein TerC family
IAI05_07945	COG1280	lysine exporter protein (LysE YggA)
IAI05_07955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IAI05_07960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IAI05_07970	COG0538	isocitrate dehydrogenase activity
IAI05_07980	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAI05_07985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAI05_07990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_07995	COG2313	pseudouridylate synthase activity
IAI05_08005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_08010	COG4215	(ABC) transporter
IAI05_08020	COG5425	PFAM Usg family protein
IAI05_08030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAI05_08035	COG1522	sequence-specific DNA binding
IAI05_08040	COG1573	uracil-dna glycosylase
IAI05_08050	COG2202	Pas domain
IAI05_08050	COG2205	protein histidine kinase activity
IAI05_08055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IAI05_08060	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IAI05_08065	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IAI05_08080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAI05_08085	COG0842	Transport permease protein
IAI05_08090	COG1131	(ABC) transporter
IAI05_08095	COG0730	response to heat
IAI05_08095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAI05_08115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IAI05_08120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAI05_08140	COG0129	dihydroxy-acid dehydratase activity
IAI05_08145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAI05_08150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IAI05_08160	COG3739	integral membrane protein
IAI05_08165	COG0203	ribosomal protein L17
IAI05_08170	COG0202	RNA polymerase activity
IAI05_08175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAI05_08180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IAI05_08185	COG0563	adenylate kinase activity
IAI05_08190	COG0201	protein transport
IAI05_08195	COG0200	Binds to the 23S rRNA
IAI05_08200	COG1841	ribosomal large subunit assembly
IAI05_08205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAI05_08210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IAI05_08215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAI05_08220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IAI05_08225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAI05_08230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IAI05_08235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IAI05_08240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAI05_08245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IAI05_08250	COG0255	Belongs to the universal ribosomal protein uL29 family
IAI05_08255	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAI05_08260	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAI05_08265	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAI05_08270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAI05_08275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAI05_08280	COG0089	rRNA binding
IAI05_08285	COG0088	Forms part of the polypeptide exit tunnel
IAI05_08290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAI05_08295	COG0051	transcription antitermination factor activity, RNA binding
IAI05_08300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAI05_08305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAI05_08310	COG0049	tRNA binding
IAI05_08315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAI05_08335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAI05_08340	COG0085	RNA polymerase activity
IAI05_08345	COG0222	ribosome binding
IAI05_08350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAI05_08355	COG0081	regulation of translation
IAI05_08360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAI05_08370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAI05_08380	COG1086	Polysaccharide biosynthesis protein
IAI05_08385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAI05_08390	COG0861	Integral membrane protein TerC family
IAI05_08395	COG3895	Periplasmic Protein
IAI05_08415	COG1132	(ABC) transporter
IAI05_08420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAI05_08440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IAI05_08475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_08475	COG2198	Histidine kinase
IAI05_08475	COG0784	Response regulator, receiver
IAI05_08475	COG2205	protein histidine kinase activity
IAI05_08480	COG0784	Response regulator, receiver
IAI05_08485	COG3920	Histidine kinase
IAI05_08485	COG2202	Pas domain
IAI05_08490	COG0784	Response regulator, receiver
IAI05_08495	COG4251	negative regulation of phosphorylation
IAI05_08520	COG3422	double-strand break repair
IAI05_08595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IAI05_08620	COG0582	viral genome integration into host DNA
IAI05_08635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAI05_08640	COG1607	acyl-coa hydrolase
IAI05_08660	COG2910	NAD(P)H-binding
IAI05_08665	COG1733	regulation of RNA biosynthetic process
IAI05_08680	COG0556	nucleotide-excision repair
IAI05_08690	COG2382	esterase
IAI05_08710	COG0484	heat shock protein binding
IAI05_08730	COG3706	GGDEF domain
IAI05_08750	COG1840	ABC-type Fe3 transport system, periplasmic component
IAI05_08755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAI05_08770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IAI05_08780	COG2207	Transcriptional regulator
IAI05_08785	COG1064	alcohol dehydrogenase
IAI05_08790	COG1252	NADH dehydrogenase
IAI05_08795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IAI05_08800	COG2197	response regulator
IAI05_08805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IAI05_08840	COG0656	L-ascorbic acid biosynthetic process
IAI05_08855	COG0440	acetolactate synthase activity
IAI05_08860	COG0028	Belongs to the TPP enzyme family
IAI05_08870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAI05_08875	COG0560	Phosphoserine phosphatase
IAI05_08875	COG3830	Belongs to the UPF0237 family
IAI05_08895	COG0330	HflC and HflK could
IAI05_08900	COG0330	HflC and HflK could
IAI05_08910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IAI05_08945	COG0277	FAD linked oxidase domain protein
IAI05_08950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAI05_08990	COG1335	isochorismatase
IAI05_09020	COG2264	protein methyltransferase activity
IAI05_09025	COG1999	signal sequence binding
IAI05_09035	COG0835	chemotaxis
IAI05_09045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAI05_09050	COG0583	DNA-binding transcription factor activity
IAI05_09060	COG1247	-acetyltransferase
IAI05_09070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAI05_09075	COG0497	DNA recombination
IAI05_09080	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IAI05_09090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAI05_09095	COG0849	cell division
IAI05_09100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IAI05_09105	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAI05_09110	COG0477	Major facilitator Superfamily
IAI05_09120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAI05_09125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAI05_09130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAI05_09140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAI05_09145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAI05_09155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAI05_09170	COG0275	rRNA processing
IAI05_09175	COG2001	Belongs to the MraZ family
IAI05_09200	COG3023	N-Acetylmuramoyl-L-alanine amidase
IAI05_09230	COG4106	trans-aconitate 2-methyltransferase activity
IAI05_09250	COG2226	methyltransferase
IAI05_09260	COG2267	carboxylic ester hydrolase activity
IAI05_09265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IAI05_09280	COG0251	oxidation-reduction process
IAI05_09295	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_09300	COG2814	Major facilitator Superfamily
IAI05_09330	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_09335	COG0174	glutamine synthetase
IAI05_09340	COG0531	amino acid
IAI05_09350	COG1737	Transcriptional regulator
IAI05_09355	COG2182	Extracellular solute-binding protein
IAI05_09370	COG3842	ATPase activity
IAI05_09440	COG2968	Membrane
IAI05_09450	COG0432	Pfam Uncharacterised protein family UPF0047
IAI05_09465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAI05_09470	COG0358	DNA primase activity
IAI05_09495	COG0505	Belongs to the CarA family
IAI05_09500	COG0534	Mate efflux family protein
IAI05_09515	COG2321	neutral zinc metallopeptidase
IAI05_09530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAI05_09540	COG3706	GGDEF domain
IAI05_09555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAI05_09565	COG1522	sequence-specific DNA binding
IAI05_09570	COG0492	ferredoxin-NADP+ reductase activity
IAI05_09575	COG0583	DNA-binding transcription factor activity
IAI05_09585	COG1902	pentaerythritol trinitrate reductase activity
IAI05_09610	COG0387	Pfam Sodium calcium exchanger
IAI05_09615	COG0436	Aminotransferase
IAI05_09620	COG2199	diguanylate cyclase activity
IAI05_09620	COG2200	EAL domain
IAI05_09635	COG1278	Cold shock
IAI05_09640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAI05_09650	COG1846	Transcriptional regulator
IAI05_09655	COG0745	RESPONSE REGULATOR receiver
IAI05_09665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAI05_09685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAI05_09695	COG1496	oxidoreductase activity
IAI05_09710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAI05_09720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IAI05_09735	COG0840	transmembrane signaling receptor activity
IAI05_09740	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_09745	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IAI05_09750	COG3300	MHYT domain
IAI05_09750	COG5001	Diguanylate cyclase
IAI05_09755	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IAI05_09760	COG5001	Diguanylate cyclase
IAI05_09770	COG0193	aminoacyl-tRNA hydrolase activity
IAI05_09780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IAI05_09805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAI05_09815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IAI05_09815	COG2857	Cytochrome c1
IAI05_09830	COG3021	interspecies interaction between organisms
IAI05_09835	COG1132	(ABC) transporter
IAI05_09840	COG1132	(ABC) transporter
IAI05_09845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IAI05_09850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IAI05_09865	COG0408	coproporphyrinogen oxidase activity
IAI05_09880	COG0617	tRNA 3'-terminal CCA addition
IAI05_09895	COG0714	Associated with various cellular activities
IAI05_09915	COG0454	-acetyltransferase
IAI05_09930	COG0477	Major facilitator Superfamily
IAI05_09940	COG0435	Glutathione S-transferase
IAI05_09945	COG0494	nUDIX hydrolase
IAI05_09955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAI05_09960	COG3135	benzoate transporter
IAI05_09985	COG0740	serine-type endopeptidase activity
IAI05_10000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IAI05_10005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IAI05_10030	COG4175	Glycine betaine
IAI05_10050	COG1435	thymidine kinase activity
IAI05_10075	COG4771	TonB-dependent receptor
IAI05_10075	COG1629	transport
IAI05_10085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAI05_10085	COG0512	Glutamine amidotransferase of anthranilate synthase
IAI05_10100	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAI05_10110	COG0366	Alpha amylase catalytic
IAI05_10115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_10135	COG1160	GTP binding
IAI05_10155	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IAI05_10165	COG0024	Methionine aminopeptidase
IAI05_10175	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_10185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IAI05_10195	COG0583	DNA-binding transcription factor activity
IAI05_10210	COG0402	S-adenosylhomocysteine deaminase activity
IAI05_10230	COG1309	transcriptional regulator
IAI05_10235	COG1686	Belongs to the peptidase S11 family
IAI05_10245	COG2351	hydroxyisourate hydrolase activity
IAI05_10250	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IAI05_10275	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IAI05_10285	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IAI05_10285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_10295	COG0513	Belongs to the DEAD box helicase family
IAI05_10305	COG2259	Doxx family
IAI05_10310	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_10320	COG2308	Evidence 4 Homologs of previously reported genes of
IAI05_10330	COG1305	Transglutaminase-like
IAI05_10360	COG4214	carbohydrate transport
IAI05_10370	COG4213	ABC transporter substrate-binding protein
IAI05_10405	COG0840	transmembrane signaling receptor activity
IAI05_10420	COG0646	methionine synthase
IAI05_10420	COG1410	methionine synthase
IAI05_10465	COG1215	transferase activity, transferring glycosyl groups
IAI05_10495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAI05_10500	COG2346	COG2346, Truncated hemoglobins
IAI05_10520	COG1309	transcriptional regulator
IAI05_10535	COG0494	nUDIX hydrolase
IAI05_10545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_10550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_10595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IAI05_10600	COG0830	nickel cation binding
IAI05_10605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IAI05_10620	COG0804	urea catabolic process
IAI05_10625	COG1442	glycosyl transferase family 8
IAI05_10630	COG3755	Protein conserved in bacteria
IAI05_10640	COG0832	Belongs to the urease beta subunit family
IAI05_10645	COG3813	Protein conserved in bacteria
IAI05_10650	COG0831	urea catabolic process
IAI05_10655	COG0829	nickel cation binding
IAI05_10680	COG0559	Belongs to the binding-protein-dependent transport system permease family
IAI05_10695	COG0174	glutamine synthetase
IAI05_10700	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_10705	COG5002	protein histidine kinase activity
IAI05_10705	COG0784	Response regulator, receiver
IAI05_10705	COG2198	Histidine kinase
IAI05_10720	COG0726	polysaccharide deacetylase
IAI05_10755	COG1218	3'(2'),5'-bisphosphate nucleotidase
IAI05_10830	COG0564	pseudouridine synthase activity
IAI05_10840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAI05_10850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAI05_10875	COG0346	lactoylglutathione lyase activity
IAI05_10885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IAI05_10895	COG2832	Protein of unknown function (DUF454)
IAI05_10900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IAI05_10905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_10910	COG4558	Periplasmic binding protein
IAI05_10920	COG3721	Heme iron utilization protein
IAI05_10935	COG3655	Transcriptional regulator
IAI05_10950	COG3657	addiction module killer protein
IAI05_10960	COG2205	protein histidine kinase activity
IAI05_11000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_11005	COG4605	iron ion homeostasis
IAI05_11010	COG4604	ABC transporter, ATP-binding protein
IAI05_11015	COG0783	Belongs to the Dps family
IAI05_11030	COG2972	Histidine kinase
IAI05_11030	COG0840	transmembrane signaling receptor activity
IAI05_11035	COG0656	L-ascorbic acid biosynthetic process
IAI05_11040	COG2814	Major facilitator Superfamily
IAI05_11050	COG0583	DNA-binding transcription factor activity
IAI05_11055	COG0657	acetylesterase activity
IAI05_11060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_11080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAI05_11085	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IAI05_11090	COG0288	reversible hydration of carbon dioxide
IAI05_11100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IAI05_11120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IAI05_11125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAI05_11130	COG0778	Nitroreductase
IAI05_11135	COG2267	carboxylic ester hydrolase activity
IAI05_11140	COG0251	oxidation-reduction process
IAI05_11145	COG1335	isochorismatase
IAI05_11150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_11160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_11175	COG1175	transmembrane transport
IAI05_11180	COG0395	ABC-type sugar transport system, permease component
IAI05_11185	COG3842	ATPase activity
IAI05_11190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_11200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAI05_11215	COG4608	Belongs to the ABC transporter superfamily
IAI05_11220	COG0444	Belongs to the ABC transporter superfamily
IAI05_11225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_11230	COG0601	transmembrane transport
IAI05_11285	COG2159	amidohydrolase
IAI05_11290	COG1960	acyl-CoA dehydrogenase activity
IAI05_11320	COG0745	RESPONSE REGULATOR receiver
IAI05_11330	COG1902	pentaerythritol trinitrate reductase activity
IAI05_11330	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAI05_11335	COG3842	ATPase activity
IAI05_11345	COG1840	ABC-type Fe3 transport system, periplasmic component
IAI05_11350	COG1840	ABC-type Fe3 transport system, periplasmic component
IAI05_11355	COG0745	RESPONSE REGULATOR receiver
IAI05_11365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IAI05_11370	COG0583	DNA-binding transcription factor activity
IAI05_11375	COG1278	Cold shock
IAI05_11415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAI05_11420	COG1309	transcriptional regulator
IAI05_11425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_11430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAI05_11440	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAI05_11445	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IAI05_11465	COG0583	DNA-binding transcription factor activity
IAI05_11470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_11475	COG0725	ABC transporter, periplasmic molybdate-binding protein
IAI05_11480	COG4149	molybdate abc transporter
IAI05_11485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IAI05_11500	COG2022	thiamine diphosphate biosynthetic process
IAI05_11515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IAI05_11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAI05_11530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IAI05_11550	COG1132	(ABC) transporter
IAI05_11555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAI05_11600	COG4166	transmembrane transport
IAI05_11610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_11625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAI05_11630	COG3142	Participates in the control of copper homeostasis
IAI05_11635	COG2814	Major facilitator Superfamily
IAI05_11650	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_11655	COG1737	Transcriptional regulator
IAI05_11665	COG3842	ATPase activity
IAI05_11675	COG0395	ABC-type sugar transport system, permease component
IAI05_11695	COG2188	Transcriptional regulator
IAI05_11700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IAI05_11705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IAI05_11710	COG1940	carbohydrate kinase activity
IAI05_11720	COG0671	phosphoesterase, PA-phosphatase related
IAI05_11725	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IAI05_11730	COG0156	8-amino-7-oxononanoate synthase activity
IAI05_11740	COG0729	surface antigen
IAI05_11750	COG0835	chemotaxis
IAI05_11760	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAI05_11765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IAI05_11770	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IAI05_11775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IAI05_11780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IAI05_11785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAI05_11800	COG4974	Belongs to the 'phage' integrase family
IAI05_11825	COG1280	lysine exporter protein (LysE YggA)
IAI05_11835	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAI05_11840	COG0567	Dehydrogenase, E1 component
IAI05_11845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAI05_11850	COG0045	succinate-CoA ligase (ADP-forming) activity
IAI05_11855	COG0039	L-malate dehydrogenase activity
IAI05_11860	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IAI05_11895	COG2264	protein methyltransferase activity
IAI05_11910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAI05_11915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAI05_11920	COG0181	hydroxymethylbilane synthase activity
IAI05_11960	COG1872	DUF167
IAI05_11965	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IAI05_11975	COG1217	gtp-binding protein TYPA
IAI05_11980	COG0339	signal peptide processing
IAI05_11985	COG1846	Transcriptional regulator
IAI05_11995	COG0137	argininosuccinate synthase activity
IAI05_12005	COG1280	lysine exporter protein (LysE YggA)
IAI05_12010	COG1122	ATPase activity
IAI05_12015	COG4120	Belongs to the binding-protein-dependent transport system permease family
IAI05_12025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAI05_12040	COG2154	pterin-4-alpha-carbinolamine dehydratase
IAI05_12045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAI05_12050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IAI05_12060	COG4181	ATPase activity
IAI05_12070	COG0670	Belongs to the BI1 family
IAI05_12085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IAI05_12090	COG4133	protoheme IX ABC transporter activity
IAI05_12095	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IAI05_12100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IAI05_12125	COG2917	probably involved in intracellular septation
IAI05_12130	COG0552	protein localization to endoplasmic reticulum
IAI05_12135	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAI05_12140	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IAI05_12155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IAI05_12160	COG0287	Prephenate dehydrogenase
IAI05_12160	COG1605	Chorismate mutase
IAI05_12165	COG0228	four-way junction DNA binding
IAI05_12170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAI05_12175	COG0336	Belongs to the RNA methyltransferase TrmD family
IAI05_12185	COG0335	large ribosomal subunit rRNA binding
IAI05_12190	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IAI05_12195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_12210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAI05_12230	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IAI05_12250	COG0488	(ABC) transporter
IAI05_12260	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IAI05_12270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAI05_12275	COG0142	geranyltranstransferase activity
IAI05_12280	COG2885	chlorophyll binding
IAI05_12285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAI05_12290	COG2223	nitrite transmembrane transporter activity
IAI05_12295	COG1349	DNA-binding transcription factor activity
IAI05_12300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IAI05_12305	COG2197	response regulator
IAI05_12310	COG1132	(ABC) transporter
IAI05_12315	COG3459	Glycosyltransferase 36 associated
IAI05_12320	COG1473	amidohydrolase
IAI05_12330	COG0579	oxidoreductase
IAI05_12340	COG0129	dihydroxy-acid dehydratase activity
IAI05_12345	COG2084	Dehydrogenase
IAI05_12350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_12355	COG0277	FAD linked oxidase domain protein
IAI05_12360	COG2186	Transcriptional regulator
IAI05_12370	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IAI05_12375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IAI05_12380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IAI05_12385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAI05_12395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IAI05_12400	COG0495	leucyl-tRNA aminoacylation
IAI05_12415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IAI05_12420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IAI05_12435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAI05_12440	COG1946	Acyl-CoA thioesterase
IAI05_12445	COG0347	Belongs to the P(II) protein family
IAI05_12450	COG0004	ammonium transporteR
IAI05_12455	COG1674	ftsk spoiiie
IAI05_12460	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IAI05_12475	COG0745	RESPONSE REGULATOR receiver
IAI05_12485	COG1329	Transcriptional regulator
IAI05_12495	COG2270	Major facilitator Superfamily
IAI05_12510	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_12525	COG0494	nUDIX hydrolase
IAI05_12530	COG2861	carbohydrate metabolic process
IAI05_12535	COG0793	Belongs to the peptidase S41A family
IAI05_12545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IAI05_12550	COG0799	negative regulation of ribosome biogenesis
IAI05_12555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IAI05_12560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IAI05_12565	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IAI05_12570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAI05_12585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IAI05_12590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IAI05_12615	COG0066	3-isopropylmalate dehydratase activity
IAI05_12620	COG0473	3-isopropylmalate dehydrogenase activity
IAI05_12625	COG1858	cytochrome C peroxidase
IAI05_12630	COG1797	cobyrinic acid a,c-diamide synthase activity
IAI05_12640	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
IAI05_12705	COG1492	cobalamin metabolic process
IAI05_12720	COG4948	Mandelate Racemase Muconate Lactonizing
IAI05_12725	COG3254	rhamnose metabolic process
IAI05_12735	COG1063	alcohol dehydrogenase
IAI05_12760	COG1129	ABC transporter
IAI05_12765	COG2186	Transcriptional regulator
IAI05_12770	COG2721	sulfolactate sulfo-lyase activity
IAI05_12775	COG0138	bifunctional purine biosynthesis protein purh
IAI05_12785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IAI05_12785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAI05_12790	COG0501	Belongs to the peptidase M48B family
IAI05_12810	COG0357	Ribosomal RNA small subunit methyltransferase G
IAI05_12815	COG0445	tRNA wobble uridine modification
IAI05_12820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IAI05_12825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IAI05_12830	COG1981	membrane
IAI05_12835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IAI05_12840	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IAI05_12845	COG0424	maF-like protein
IAI05_12850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAI05_12855	COG0237	dephospho-CoA kinase activity
IAI05_12865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IAI05_12870	COG3030	protein affecting phage T7 exclusion by the F plasmid
IAI05_12880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IAI05_12905	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAI05_12920	COG0135	phosphoribosylanthranilate isomerase activity
IAI05_12925	COG0133	tryptophan synthase activity
IAI05_12930	COG0159	tryptophan synthase activity
IAI05_12935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAI05_12950	COG1074	ATP-dependent DNA helicase activity
IAI05_12960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IAI05_12965	COG0802	atpase or kinase
IAI05_12970	COG2205	protein histidine kinase activity
IAI05_12975	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IAI05_12980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAI05_12985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAI05_12985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAI05_12990	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IAI05_12995	COG0642	Histidine kinase
IAI05_13000	COG0745	RESPONSE REGULATOR receiver
IAI05_13005	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IAI05_13015	COG1652	LysM domain
IAI05_13020	COG1072	(Pantothenic acid kinase))
IAI05_13025	COG0140	phosphoribosyl-ATP diphosphatase activity
IAI05_13030	COG0107	imidazoleglycerol-phosphate synthase activity
IAI05_13035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IAI05_13040	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IAI05_13050	COG0131	Imidazoleglycerol-phosphate dehydratase
IAI05_13055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IAI05_13060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IAI05_13070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IAI05_13085	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IAI05_13095	COG1643	Atp-dependent helicase
IAI05_13155	COG1072	(Pantothenic acid kinase))
IAI05_13165	COG1780	Probably involved in ribonucleotide reductase function
IAI05_13175	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAI05_13185	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAI05_13215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_13225	COG2813	Specifically methylates the guanine in position
IAI05_13230	COG1185	polyribonucleotide nucleotidyltransferase activity
IAI05_13235	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IAI05_13240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAI05_13245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAI05_13250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAI05_13250	COG3064	Membrane
IAI05_13265	COG0779	Required for maturation of 30S ribosomal subunits
IAI05_13270	COG2814	Major facilitator Superfamily
IAI05_13275	COG2951	lytic endotransglycosylase activity
IAI05_13280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAI05_13290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IAI05_13295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IAI05_13310	COG2816	NAD+ diphosphatase activity
IAI05_13315	COG0077	Prephenate dehydratase
IAI05_13315	COG1605	Chorismate mutase
IAI05_13320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IAI05_13325	COG3474	cytochrome
IAI05_13335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAI05_13340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IAI05_13345	COG1278	Cold shock
IAI05_13350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAI05_13360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAI05_13360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAI05_13365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IAI05_13395	COG2900	Belongs to the SlyX family
IAI05_13405	COG0484	heat shock protein binding
IAI05_13410	COG0443	Heat shock 70 kDa protein
IAI05_13425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAI05_13430	COG1744	ABC transporter substrate-binding protein PnrA-like
IAI05_13435	COG3845	ABC transporter
IAI05_13440	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAI05_13445	COG1079	Belongs to the binding-protein-dependent transport system permease family
IAI05_13450	COG0295	cytidine deaminase activity
IAI05_13460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IAI05_13465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IAI05_13475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAI05_13480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAI05_13485	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IAI05_13495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IAI05_13500	COG1845	cytochrome c oxidase, subunit III
IAI05_13505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAI05_13510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAI05_13515	COG0477	Major facilitator Superfamily
IAI05_13520	COG0070	glutamate synthase
IAI05_13520	COG0067	glutamate synthase
IAI05_13520	COG0069	glutamate synthase activity
IAI05_13525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IAI05_13540	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IAI05_13550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAI05_13580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_13600	COG0848	biopolymer transport protein
IAI05_13610	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IAI05_13625	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IAI05_13630	COG3454	Phosphonate metabolism
IAI05_13635	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IAI05_13640	COG3639	organic phosphonate transmembrane transporter activity
IAI05_13645	COG3639	organic phosphonate transmembrane transporter activity
IAI05_13655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IAI05_13665	COG4778	phosphonate C-P lyase system protein PhnL
IAI05_13670	COG4107	phosphonate C-P lyase system protein PhnK
IAI05_13675	COG3627	carbon phosphorus lyase activity
IAI05_13680	COG3626	phosphonate metabolism
IAI05_13685	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IAI05_13690	COG3624	Phosphonate C-P lyase system protein PhnG
IAI05_13695	COG2188	Transcriptional regulator
IAI05_13700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IAI05_13705	COG0837	glucose binding
IAI05_13710	COG1803	Methylglyoxal synthase
IAI05_13715	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IAI05_13720	COG4166	transmembrane transport
IAI05_13725	COG4174	ABC transporter (Permease)
IAI05_13730	COG4239	(ABC) transporter, permease
IAI05_13735	COG4172	Belongs to the ABC transporter superfamily
IAI05_13740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_13745	COG0174	glutamine synthetase
IAI05_13750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_13755	COG3265	gluconokinase activity
IAI05_13760	COG1174	glycine betaine transport
IAI05_13765	COG1125	glycine betaine transport
IAI05_13770	COG1174	glycine betaine transport
IAI05_13775	COG1732	Glycine betaine
IAI05_13785	COG1959	2 iron, 2 sulfur cluster binding
IAI05_13790	COG1840	ABC-type Fe3 transport system, periplasmic component
IAI05_13800	COG4269	membrane
IAI05_13815	COG0697	spore germination
IAI05_13830	COG0791	NLP P60 protein
IAI05_13840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IAI05_13845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAI05_13880	COG4964	Belongs to the GSP D family
IAI05_13925	COG3422	double-strand break repair
IAI05_13930	COG3757	hydrolase, family 25
IAI05_13935	COG0697	spore germination
IAI05_13940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAI05_13955	COG0492	ferredoxin-NADP+ reductase activity
IAI05_13970	COG0481	GTPase activity
IAI05_13975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAI05_13990	COG1396	sequence-specific DNA binding
IAI05_14005	COG2169	Transcriptional regulator
IAI05_14005	COG1917	Cupin 2, conserved barrel domain protein
IAI05_14010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IAI05_14035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAI05_14040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAI05_14045	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IAI05_14055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAI05_14060	COG0072	phenylalanine-tRNA ligase activity
IAI05_14060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAI05_14065	COG0667	Aldo Keto reductase
IAI05_14085	COG4977	sequence-specific DNA binding
IAI05_14110	COG1570	exodeoxyribonuclease VII activity
IAI05_14115	COG4948	Mandelate Racemase Muconate Lactonizing
IAI05_14125	COG1846	Transcriptional regulator
IAI05_14130	COG0697	spore germination
IAI05_14135	COG2309	aminopeptidase activity
IAI05_14140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IAI05_14145	COG1393	Belongs to the ArsC family
IAI05_14165	COG1309	transcriptional regulator
IAI05_14175	COG0519	Catalyzes the synthesis of GMP from XMP
IAI05_14175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAI05_14190	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IAI05_14220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IAI05_14230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAI05_14240	COG1968	undecaprenyl-diphosphatase activity
IAI05_14255	COG0284	orotidine-5'-phosphate decarboxylase activity
IAI05_14265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAI05_14275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IAI05_14280	COG0792	nuclease activity
IAI05_14295	COG1175	transmembrane transport
IAI05_14300	COG0395	ABC-type sugar transport system, permease component
IAI05_14305	COG3842	ATPase activity
IAI05_14315	COG0189	ligase activity
IAI05_14325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAI05_14330	COG1280	lysine exporter protein (LysE YggA)
IAI05_14335	COG0756	dUTP diphosphatase activity
IAI05_14340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IAI05_14345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IAI05_14360	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IAI05_14365	COG2226	methyltransferase
IAI05_14370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAI05_14375	COG1024	Enoyl-CoA hydratase
IAI05_14380	COG0268	Binds directly to 16S ribosomal RNA
IAI05_14425	COG1278	Cold shock
IAI05_14470	COG0411	ABC transporter
IAI05_14475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAI05_14480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAI05_14485	COG1454	alcohol dehydrogenase
IAI05_14490	COG0747	negative chemotaxis
IAI05_14495	COG0601	transmembrane transport
IAI05_14505	COG4608	Belongs to the ABC transporter superfamily
IAI05_14510	COG1349	DNA-binding transcription factor activity
IAI05_14515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAI05_14540	COG4302	ethanolamine ammonia-lyase activity
IAI05_14545	COG0025	NhaP-type Na H and K H
IAI05_14550	COG4106	trans-aconitate 2-methyltransferase activity
IAI05_14565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_14570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_14575	COG0601	transmembrane transport
IAI05_14580	COG0747	negative chemotaxis
IAI05_14600	COG4172	Belongs to the ABC transporter superfamily
IAI05_14625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAI05_14625	COG0785	Cytochrome C biogenesis protein
IAI05_14635	COG0596	Alpha beta hydrolase
IAI05_14650	COG1764	response to oxidative stress
IAI05_14660	COG0596	Alpha beta hydrolase
IAI05_14680	COG0783	Belongs to the Dps family
IAI05_14685	COG0243	molybdopterin cofactor binding
IAI05_14695	COG4566	intracellular signal transduction
IAI05_14700	COG4566	intracellular signal transduction
IAI05_14710	COG2140	Oxalate decarboxylase
IAI05_14720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IAI05_14725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IAI05_14725	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IAI05_14730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IAI05_14740	COG1414	Transcriptional regulator
IAI05_14755	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_14775	COG1522	sequence-specific DNA binding
IAI05_14800	COG0628	permease
IAI05_14810	COG2235	arginine
IAI05_14830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_14845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAI05_14855	COG0702	epimerase
IAI05_14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAI05_14865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_14870	COG0745	RESPONSE REGULATOR receiver
IAI05_14875	COG5002	protein histidine kinase activity
IAI05_14890	COG2233	PERMEase
IAI05_14950	COG0395	ABC-type sugar transport system, permease component
IAI05_14955	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAI05_14965	COG3842	ATPase activity
IAI05_15000	COG1653	transport
IAI05_15010	COG0395	ABC-type sugar transport system, permease component
IAI05_15015	COG3842	ATPase activity
IAI05_15030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAI05_15035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_15040	COG1116	anion transmembrane transporter activity
IAI05_15045	COG0395	ABC-type sugar transport system, permease component
IAI05_15050	COG1175	transmembrane transport
IAI05_15080	COG1609	Transcriptional regulator
IAI05_15095	COG1082	Xylose isomerase domain protein TIM barrel
IAI05_15100	COG3842	ATPase activity
IAI05_15105	COG0395	ABC-type sugar transport system, permease component
IAI05_15110	COG1175	transmembrane transport
IAI05_15115	COG1653	transport
IAI05_15120	COG1309	transcriptional regulator
IAI05_15125	COG0673	inositol 2-dehydrogenase activity
IAI05_15140	COG0673	inositol 2-dehydrogenase activity
IAI05_15150	COG1278	Cold shock
IAI05_15160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IAI05_15185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAI05_15190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IAI05_15205	COG3842	ATPase activity
IAI05_15210	COG0395	ABC-type sugar transport system, permease component
IAI05_15215	COG1175	transmembrane transport
IAI05_15225	COG3618	amidohydrolase
IAI05_15230	COG4948	Mandelate Racemase Muconate Lactonizing
IAI05_15235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_15240	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_15245	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IAI05_15250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_15255	COG2186	Transcriptional regulator
IAI05_15270	COG0667	Aldo Keto reductase
IAI05_15300	COG4977	sequence-specific DNA binding
IAI05_15305	COG2223	nitrite transmembrane transporter activity
IAI05_15310	COG1609	Transcriptional regulator
IAI05_15315	COG1063	alcohol dehydrogenase
IAI05_15320	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_15330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_15335	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
IAI05_15340	COG1175	transmembrane transport
IAI05_15345	COG0395	ABC-type sugar transport system, permease component
IAI05_15360	COG0395	ABC-type sugar transport system, permease component
IAI05_15365	COG1175	transmembrane transport
IAI05_15370	COG2182	Extracellular solute-binding protein
IAI05_15375	COG0626	cystathionine gamma-synthase activity
IAI05_15390	COG0454	-acetyltransferase
IAI05_15395	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAI05_15405	COG1121	(ABC) transporter
IAI05_15410	COG0523	cobalamin synthesis protein
IAI05_15425	COG0523	cobalamin synthesis protein
IAI05_15430	COG1653	transport
IAI05_15435	COG1175	transmembrane transport
IAI05_15440	COG0395	ABC-type sugar transport system, permease component
IAI05_15445	COG3842	ATPase activity
IAI05_15455	COG3047	cAMP biosynthetic process
IAI05_15480	COG0583	DNA-binding transcription factor activity
IAI05_15485	COG1879	ABC-type sugar transport system periplasmic component
IAI05_15490	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_15495	COG1129	ABC transporter
IAI05_15505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAI05_15510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_15520	COG3257	ureidoglycine aminohydrolase activity
IAI05_15530	COG5001	Diguanylate cyclase
IAI05_15535	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IAI05_15545	COG0747	negative chemotaxis
IAI05_15550	COG0601	transmembrane transport
IAI05_15555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_15565	COG4608	Belongs to the ABC transporter superfamily
IAI05_15570	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IAI05_15585	COG0346	lactoylglutathione lyase activity
IAI05_15595	COG0129	dihydroxy-acid dehydratase activity
IAI05_15600	COG1879	ABC-type sugar transport system periplasmic component
IAI05_15605	COG1129	ABC transporter
IAI05_15610	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_15615	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_15620	COG2186	Transcriptional regulator
IAI05_15635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAI05_15640	COG0587	DNA-directed DNA polymerase activity
IAI05_15670	COG0673	inositol 2-dehydrogenase activity
IAI05_15680	COG3842	ATPase activity
IAI05_15685	COG0395	ABC-type sugar transport system, permease component
IAI05_15690	COG1175	transmembrane transport
IAI05_15695	COG1653	transport
IAI05_15705	COG0673	inositol 2-dehydrogenase activity
IAI05_15720	COG5001	Diguanylate cyclase
IAI05_15735	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IAI05_15740	COG2894	cell division
IAI05_15745	COG0850	regulation of cytokinetic process
IAI05_15750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAI05_15755	COG2186	Transcriptional regulator
IAI05_15760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IAI05_15770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IAI05_15775	COG1063	alcohol dehydrogenase
IAI05_15780	COG1312	Catalyzes the dehydration of D-mannonate
IAI05_15800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IAI05_15805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IAI05_15805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IAI05_15810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_15825	COG0625	glutathione transferase activity
IAI05_15835	COG1921	L-seryl-tRNASec selenium transferase activity
IAI05_15850	COG3964	amidohydrolase
IAI05_15860	COG0601	transmembrane transport
IAI05_15865	COG0747	negative chemotaxis
IAI05_15870	COG0438	transferase activity, transferring glycosyl groups
IAI05_15905	COG4989	oxidoreductase activity
IAI05_15915	COG2188	Transcriptional regulator
IAI05_15920	COG3842	ATPase activity
IAI05_15925	COG1653	transport
IAI05_15930	COG1175	transmembrane transport
IAI05_15935	COG0395	ABC-type sugar transport system, permease component
IAI05_15940	COG1501	Belongs to the glycosyl hydrolase 31 family
IAI05_15950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_15955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAI05_15960	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IAI05_15965	COG0352	thiamine-phosphate diphosphorylase activity
IAI05_15970	COG0351	phosphomethylpyrimidine kinase
IAI05_15975	COG1522	sequence-specific DNA binding
IAI05_15980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAI05_15985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_16000	COG2204	response regulator
IAI05_16005	COG4191	Histidine kinase
IAI05_16010	COG1301	dicarboxylic acid transport
IAI05_16015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAI05_16020	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_16030	COG1473	amidohydrolase
IAI05_16050	COG1215	transferase activity, transferring glycosyl groups
IAI05_16060	COG2942	2-epimerase
IAI05_16085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_16095	COG2197	response regulator
IAI05_16125	COG3307	-O-antigen
IAI05_16130	COG1596	polysaccharide export
IAI05_16135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IAI05_16145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAI05_16150	COG0840	transmembrane signaling receptor activity
IAI05_16155	COG1376	ErfK ybiS ycfS ynhG family protein
IAI05_16165	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_16175	COG2094	Belongs to the DNA glycosylase MPG family
IAI05_16190	COG1609	Transcriptional regulator
IAI05_16195	COG1653	transport
IAI05_16210	COG3842	ATPase activity
IAI05_16220	COG0673	inositol 2-dehydrogenase activity
IAI05_16225	COG0602	queuosine metabolic process
IAI05_16230	COG0720	synthase
IAI05_16235	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IAI05_16245	COG0673	inositol 2-dehydrogenase activity
IAI05_16260	COG0395	ABC-type sugar transport system, permease component
IAI05_16265	COG1175	transmembrane transport
IAI05_16290	COG0583	DNA-binding transcription factor activity
IAI05_16295	COG0280	phosphate acetyltransferase
IAI05_16295	COG0281	malic enzyme
IAI05_16310	COG0765	amino acid transport
IAI05_16315	COG1126	abc transporter atp-binding protein
IAI05_16320	COG2079	MmgE PrpD family protein
IAI05_16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_16350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IAI05_16360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IAI05_16365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAI05_16370	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_16375	COG1129	ABC transporter
IAI05_16390	COG1473	amidohydrolase
IAI05_16410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_16415	COG0601	transmembrane transport
IAI05_16420	COG0583	DNA-binding transcription factor activity
IAI05_16425	COG1446	asparaginase
IAI05_16440	COG0747	negative chemotaxis
IAI05_16460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_16465	COG0601	transmembrane transport
IAI05_16470	COG2197	response regulator
IAI05_16475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IAI05_16480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_16490	COG3842	ATPase activity
IAI05_16495	COG0395	ABC-type sugar transport system, permease component
IAI05_16500	COG1175	transmembrane transport
IAI05_16510	COG0673	inositol 2-dehydrogenase activity
IAI05_16515	COG0673	inositol 2-dehydrogenase activity
IAI05_16535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_16540	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IAI05_16560	COG1595	DNA-templated transcription, initiation
IAI05_16565	COG1120	ATPase activity
IAI05_16570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_16585	COG2226	methyltransferase
IAI05_16595	COG1120	ATPase activity
IAI05_16600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_16620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAI05_16645	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_16650	COG0473	3-isopropylmalate dehydrogenase activity
IAI05_16655	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_16660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_16695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_16700	COG4172	Belongs to the ABC transporter superfamily
IAI05_16705	COG1522	sequence-specific DNA binding
IAI05_16715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_16730	COG0583	DNA-binding transcription factor activity
IAI05_16740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_16745	COG1126	abc transporter atp-binding protein
IAI05_16755	COG1473	amidohydrolase
IAI05_16760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16770	COG1959	2 iron, 2 sulfur cluster binding
IAI05_16780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAI05_16785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16815	COG1960	acyl-CoA dehydrogenase activity
IAI05_16825	COG0747	negative chemotaxis
IAI05_16840	COG0444	Belongs to the ABC transporter superfamily
IAI05_16850	COG0667	Aldo Keto reductase
IAI05_16860	COG0583	DNA-binding transcription factor activity
IAI05_16865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16870	COG4166	transmembrane transport
IAI05_16880	COG0747	negative chemotaxis
IAI05_16885	COG1473	amidohydrolase
IAI05_16890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_16930	COG4608	Belongs to the ABC transporter superfamily
IAI05_16935	COG0444	Belongs to the ABC transporter superfamily
IAI05_16945	COG0601	transmembrane transport
IAI05_16955	COG2186	Transcriptional regulator
IAI05_16980	COG3453	Protein conserved in bacteria
IAI05_16980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAI05_16985	COG0640	Transcriptional regulator
IAI05_16995	COG2391	methyltransferase activity
IAI05_17000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IAI05_17010	COG0022	dehydrogenase e1 component
IAI05_17020	COG1960	acyl-CoA dehydrogenase activity
IAI05_17025	COG0183	Belongs to the thiolase family
IAI05_17035	COG1960	acyl-CoA dehydrogenase activity
IAI05_17040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAI05_17060	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAI05_17065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAI05_17070	COG4952	isomerase
IAI05_17075	COG3347	Dehydrogenase
IAI05_17075	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_17080	COG1349	DNA-binding transcription factor activity
IAI05_17090	COG1129	ABC transporter
IAI05_17095	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_17100	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_17105	COG3254	rhamnose metabolic process
IAI05_17120	COG2264	protein methyltransferase activity
IAI05_17125	COG5001	Diguanylate cyclase
IAI05_17140	COG4335	DNA alkylation repair
IAI05_17145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAI05_17150	COG4208	sulfate ABC transporter
IAI05_17160	COG4150	thiosulfate binding
IAI05_17165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IAI05_17180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAI05_17190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IAI05_17200	COG1040	competence protein
IAI05_17205	COG2226	methyltransferase
IAI05_17220	COG0494	nUDIX hydrolase
IAI05_17230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IAI05_17235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IAI05_17240	COG0653	protein targeting
IAI05_17245	COG0697	spore germination
IAI05_17310	COG2244	polysaccharide biosynthetic process
IAI05_17325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAI05_17335	COG0489	protein tyrosine kinase activity
IAI05_17335	COG3206	protein involved in exopolysaccharide biosynthesis
IAI05_17355	COG0438	transferase activity, transferring glycosyl groups
IAI05_17360	COG0438	transferase activity, transferring glycosyl groups
IAI05_17375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAI05_17380	COG2273	Hydrolase Family 16
IAI05_17380	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
IAI05_17395	COG3842	ATPase activity
IAI05_17400	COG3833	ABC-type maltose transport systems, permease component
IAI05_17455	COG1396	sequence-specific DNA binding
IAI05_17465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IAI05_17470	COG1129	ABC transporter
IAI05_17475	COG4214	carbohydrate transport
IAI05_17480	COG4213	ABC transporter substrate-binding protein
IAI05_17495	COG0346	lactoylglutathione lyase activity
IAI05_17500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAI05_17500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IAI05_17505	COG4770	biotin carboxylase activity
IAI05_17520	COG0625	glutathione transferase activity
IAI05_17525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IAI05_17530	COG1396	sequence-specific DNA binding
IAI05_17530	COG3800	Transcriptional regulator
IAI05_17540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAI05_17550	COG0300	oxidoreductase activity
IAI05_17560	COG2096	Adenosyltransferase
IAI05_17570	COG2086	electron transfer activity
IAI05_17580	COG1250	3-hydroxyacyl-CoA dehydrogenase
IAI05_17590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAI05_17595	COG0165	Argininosuccinate lyase
IAI05_17630	COG2884	Cell division ATP-binding protein ftsE
IAI05_17650	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IAI05_17660	COG0287	Prephenate dehydrogenase
IAI05_17665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAI05_17670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAI05_17675	COG2226	methyltransferase
IAI05_17680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAI05_17700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAI05_17705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IAI05_17745	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAI05_17750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAI05_17760	COG4974	Belongs to the 'phage' integrase family
IAI05_17765	COG0825	malonyl-CoA metabolic process
IAI05_17770	COG3034	peptidoglycan biosynthetic process
IAI05_17775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAI05_17775	COG0425	Belongs to the sulfur carrier protein TusA family
IAI05_17780	COG0523	cobalamin synthesis protein
IAI05_17785	COG1686	Belongs to the peptidase S11 family
IAI05_17790	COG1473	amidohydrolase
IAI05_17800	COG4953	penicillin-binding protein 1C
IAI05_17805	COG2373	Large extracellular alpha-helical protein
IAI05_17810	COG2835	tetraacyldisaccharide 4'-kinase activity
IAI05_17935	COG0482	sulfurtransferase activity
IAI05_17950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAI05_17965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAI05_17970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAI05_17975	COG0037	tRNA processing
IAI05_17985	COG2885	chlorophyll binding
IAI05_17990	COG0823	Involved in the tonB-independent uptake of proteins
IAI05_18010	COG0824	Thioesterase
IAI05_18020	COG0494	nUDIX hydrolase
IAI05_18035	COG2255	four-way junction helicase activity
IAI05_18040	COG0632	four-way junction helicase activity
IAI05_18045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IAI05_18050	COG0840	transmembrane signaling receptor activity
IAI05_18055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_18060	COG0217	transcriptional regulatory protein
IAI05_18075	COG1692	metallophosphoesterase
IAI05_18085	COG1253	flavin adenine dinucleotide binding
IAI05_18125	COG0126	phosphoglycerate kinase activity
IAI05_18130	COG3588	fructose-bisphosphate aldolase
IAI05_18155	COG0254	rRNA binding
IAI05_18160	COG1132	(ABC) transporter
IAI05_18180	COG0483	inositol monophosphate 1-phosphatase activity
IAI05_18210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IAI05_18215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IAI05_18220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IAI05_18225	COG0457	Tetratricopeptide repeat
IAI05_18230	COG3750	Belongs to the UPF0335 family
IAI05_18250	COG0469	pyruvate kinase activity
IAI05_18255	COG3108	Peptidase M15
IAI05_18260	COG2204	response regulator
IAI05_18265	COG1164	Oligoendopeptidase f
IAI05_18270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAI05_18280	COG5310	Homospermidine synthase
IAI05_18290	COG0737	Belongs to the 5'-nucleotidase family
IAI05_18295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IAI05_18300	COG0330	HflC and HflK could
IAI05_18325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAI05_18330	COG2951	lytic endotransglycosylase activity
IAI05_18345	COG2205	protein histidine kinase activity
IAI05_18360	COG0070	glutamate synthase
IAI05_18360	COG0069	glutamate synthase activity
IAI05_18360	COG0067	glutamate synthase
IAI05_18375	COG2205	protein histidine kinase activity
IAI05_18380	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IAI05_18385	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IAI05_18395	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IAI05_18405	COG0252	asparaginase activity
IAI05_18415	COG1027	Aspartate ammonia-lyase
IAI05_18420	COG2186	Transcriptional regulator
IAI05_18440	COG1309	transcriptional regulator
IAI05_18460	COG4176	ABC-type proline glycine betaine transport system permease component
IAI05_18465	COG0517	IMP dehydrogenase activity
IAI05_18465	COG4175	Glycine betaine
IAI05_18470	COG2986	histidine ammonia-lyase
IAI05_18475	COG1609	Transcriptional regulator
IAI05_18495	COG1082	Xylose isomerase domain protein TIM barrel
IAI05_18500	COG0673	inositol 2-dehydrogenase activity
IAI05_18505	COG1082	Xylose isomerase domain protein TIM barrel
IAI05_18530	COG3586	endonuclease activity
IAI05_18545	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IAI05_18550	COG1451	nucleotide metabolic process
IAI05_18590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_18600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_18605	COG0601	transmembrane transport
IAI05_18610	COG0747	negative chemotaxis
IAI05_18620	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IAI05_18625	COG1454	alcohol dehydrogenase
IAI05_18665	COG2307	Protein conserved in bacteria
IAI05_18665	COG2308	Evidence 4 Homologs of previously reported genes of
IAI05_18680	COG0488	(ABC) transporter
IAI05_18685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAI05_18690	COG2186	Transcriptional regulator
IAI05_18705	COG1175	transmembrane transport
IAI05_18710	COG0395	ABC-type sugar transport system, permease component
IAI05_18720	COG3842	ATPase activity
IAI05_18745	COG1304	FMN binding
IAI05_18760	COG1063	alcohol dehydrogenase
IAI05_18765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IAI05_18770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_18780	COG0765	amino acid transport
IAI05_18785	COG0765	amino acid transport
IAI05_18790	COG4221	oxidoreductase activity
IAI05_18795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAI05_18800	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_18805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_18820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IAI05_18835	COG0697	spore germination
IAI05_18840	COG0697	spore germination
IAI05_18845	COG0511	ligase activity, forming carbon-carbon bonds
IAI05_18850	COG0439	Biotin carboxylase
IAI05_18860	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAI05_18865	COG1984	allophanate hydrolase subunit 2
IAI05_18870	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IAI05_18875	COG3842	ATPase activity
IAI05_18885	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IAI05_18895	COG0436	Aminotransferase
IAI05_18910	COG2972	Histidine kinase
IAI05_18910	COG0840	transmembrane signaling receptor activity
IAI05_18915	COG1070	Carbohydrate kinase
IAI05_18920	COG1830	Aldolase
IAI05_18925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAI05_18930	COG0667	Aldo Keto reductase
IAI05_18940	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_18945	COG1129	ABC transporter
IAI05_18950	COG1879	ABC-type sugar transport system periplasmic component
IAI05_18985	COG0071	Belongs to the small heat shock protein (HSP20) family
IAI05_19000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAI05_19015	COG0395	ABC-type sugar transport system, permease component
IAI05_19030	COG3842	ATPase activity
IAI05_19045	COG1648	precorrin-2 dehydrogenase activity
IAI05_19045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAI05_19050	COG0243	molybdopterin cofactor binding
IAI05_19060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAI05_19065	COG1116	anion transmembrane transporter activity
IAI05_19070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_19075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAI05_19085	COG3707	response regulator
IAI05_19090	COG1802	Transcriptional regulator
IAI05_19095	COG1914	H( )-stimulated, divalent metal cation uptake system
IAI05_19100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IAI05_19105	COG4336	lyase activity
IAI05_19110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAI05_19115	COG4770	biotin carboxylase activity
IAI05_19120	COG0366	Alpha amylase catalytic
IAI05_19130	COG4771	TonB-dependent receptor
IAI05_19135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAI05_19155	COG1414	Transcriptional regulator
IAI05_19160	COG1475	DNA binding
IAI05_19165	COG1192	Involved in chromosome partitioning
IAI05_19195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IAI05_19205	COG2986	histidine ammonia-lyase
IAI05_19210	COG1228	amidohydrolase
IAI05_19215	COG0402	S-adenosylhomocysteine deaminase activity
IAI05_19260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAI05_19270	COG1280	lysine exporter protein (LysE YggA)
IAI05_19285	COG1309	transcriptional regulator
IAI05_19290	COG4221	oxidoreductase activity
IAI05_19295	COG1902	pentaerythritol trinitrate reductase activity
IAI05_19300	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_19305	COG2267	carboxylic ester hydrolase activity
IAI05_19325	COG1278	Cold shock
IAI05_19345	COG0753	catalase activity
IAI05_19370	COG3920	Histidine kinase
IAI05_19400	COG1129	ABC transporter
IAI05_19405	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_19410	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_19435	COG0667	Aldo Keto reductase
IAI05_19450	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_19460	COG4213	ABC transporter substrate-binding protein
IAI05_19480	COG4608	Belongs to the ABC transporter superfamily
IAI05_19485	COG0444	Belongs to the ABC transporter superfamily
IAI05_19490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_19495	COG0601	transmembrane transport
IAI05_19500	COG0747	negative chemotaxis
IAI05_19520	COG0765	amino acid transport
IAI05_19525	COG4597	amino acid ABC transporter
IAI05_19530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_19545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAI05_19550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IAI05_19560	COG1566	PFAM secretion protein HlyD family protein
IAI05_19570	COG0625	glutathione transferase activity
IAI05_19575	COG4221	oxidoreductase activity
IAI05_19580	COG4172	Belongs to the ABC transporter superfamily
IAI05_19585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_19590	COG0601	transmembrane transport
IAI05_19595	COG4166	transmembrane transport
IAI05_19600	COG0395	ABC-type sugar transport system, permease component
IAI05_19615	COG1566	PFAM secretion protein HlyD family protein
IAI05_19630	COG2207	Transcriptional regulator
IAI05_19635	COG1309	transcriptional regulator
IAI05_19640	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_19665	COG1846	Transcriptional regulator
IAI05_19670	COG0583	DNA-binding transcription factor activity
IAI05_19675	COG2828	Protein conserved in bacteria
IAI05_19690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_19705	COG0840	transmembrane signaling receptor activity
IAI05_19725	COG1216	Glycosyl transferase, family 2
IAI05_19755	COG0583	DNA-binding transcription factor activity
IAI05_19760	COG0346	lactoylglutathione lyase activity
IAI05_19775	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IAI05_19795	COG0583	DNA-binding transcription factor activity
IAI05_19800	COG0477	Major facilitator Superfamily
IAI05_19810	COG2205	protein histidine kinase activity
IAI05_19815	COG0745	RESPONSE REGULATOR receiver
IAI05_19820	COG0671	phosphoesterase, PA-phosphatase related
IAI05_19870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IAI05_19875	COG0156	8-amino-7-oxononanoate synthase activity
IAI05_19880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAI05_19885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAI05_19890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAI05_19905	COG0010	Belongs to the arginase family
IAI05_19915	COG0697	spore germination
IAI05_19920	COG0673	inositol 2-dehydrogenase activity
IAI05_19940	COG0477	Major facilitator Superfamily
IAI05_19955	COG2194	sulfuric ester hydrolase activity
IAI05_19965	COG0583	DNA-binding transcription factor activity
IAI05_19970	COG4774	siderophore transport
IAI05_19985	COG1120	ATPase activity
IAI05_19995	COG3474	cytochrome
IAI05_20000	COG2137	regulation of response to DNA damage stimulus
IAI05_20005	COG3386	PFAM SMP-30 Gluconolaconase
IAI05_20015	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_20020	COG1129	ABC transporter
IAI05_20025	COG1879	ABC-type sugar transport system periplasmic component
IAI05_20030	COG4585	Histidine kinase
IAI05_20035	COG2197	response regulator
IAI05_20045	COG2133	pyrroloquinoline quinone binding
IAI05_20055	COG0500	methyltransferase
IAI05_20060	COG0564	pseudouridine synthase activity
IAI05_20075	COG4175	Glycine betaine
IAI05_20075	COG3448	diguanylate cyclase activity
IAI05_20080	COG4176	ABC-type proline glycine betaine transport system permease component
IAI05_20095	COG4191	Histidine kinase
IAI05_20095	COG0784	Response regulator, receiver
IAI05_20100	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAI05_20105	COG3206	protein involved in exopolysaccharide biosynthesis
IAI05_20105	COG0489	protein tyrosine kinase activity
IAI05_20110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAI05_20115	COG1215	transferase activity, transferring glycosyl groups
IAI05_20120	COG1215	transferase activity, transferring glycosyl groups
IAI05_20125	COG1215	transferase activity, transferring glycosyl groups
IAI05_20130	COG0438	transferase activity, transferring glycosyl groups
IAI05_20135	COG2273	Hydrolase Family 16
IAI05_20140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IAI05_20145	COG2244	polysaccharide biosynthetic process
IAI05_20150	COG0463	Glycosyl transferase, family 2
IAI05_20155	COG2327	Polysaccharide pyruvyl transferase
IAI05_20160	COG1215	transferase activity, transferring glycosyl groups
IAI05_20180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IAI05_20185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_20200	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAI05_20200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAI05_20230	COG1523	belongs to the glycosyl hydrolase 13 family
IAI05_20235	COG0033	Phosphoglucomutase
IAI05_20240	COG0297	glycogen (starch) synthase activity
IAI05_20245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IAI05_20250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IAI05_20255	COG0058	SHG alpha-glucan phosphorylase activity
IAI05_20270	COG1794	racemase activity, acting on amino acids and derivatives
IAI05_20275	COG1522	sequence-specific DNA binding
IAI05_20285	COG2084	Dehydrogenase
IAI05_20290	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_20295	COG1063	alcohol dehydrogenase
IAI05_20305	COG4988	ABC transporter
IAI05_20310	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IAI05_20320	COG1294	oxidase, subunit
IAI05_20350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAI05_20355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IAI05_20385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IAI05_20390	COG0539	negative regulation of cytoplasmic translation
IAI05_20420	COG4221	oxidoreductase activity
IAI05_20430	COG0747	negative chemotaxis
IAI05_20435	COG0601	transmembrane transport
IAI05_20440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_20445	COG0444	Belongs to the ABC transporter superfamily
IAI05_20450	COG4608	Belongs to the ABC transporter superfamily
IAI05_20455	COG0246	Mannitol dehydrogenase
IAI05_20470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_20515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAI05_20520	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_20535	COG4993	Dehydrogenase
IAI05_20540	COG3685	Protein conserved in bacteria
IAI05_20570	COG0693	protein deglycase activity
IAI05_20590	COG0189	ligase activity
IAI05_20595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAI05_20600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IAI05_20615	COG0435	Glutathione S-transferase
IAI05_20620	COG0583	DNA-binding transcription factor activity
IAI05_20625	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_20630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IAI05_20635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAI05_20640	COG1116	anion transmembrane transporter activity
IAI05_20650	COG1522	sequence-specific DNA binding
IAI05_20665	COG0784	Response regulator, receiver
IAI05_20675	COG3920	Histidine kinase
IAI05_20685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IAI05_20700	COG0019	diaminopimelate decarboxylase activity
IAI05_20715	COG0527	aspartate kinase activity
IAI05_20725	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IAI05_20730	COG2890	protein-(glutamine-N5) methyltransferase activity
IAI05_20740	COG0542	response to heat
IAI05_20745	COG0739	heme binding
IAI05_20745	COG0741	lytic transglycosylase activity
IAI05_20745	COG1196	nuclear chromosome segregation
IAI05_20815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAI05_20820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAI05_20825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAI05_20835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAI05_20840	COG0210	DNA helicase
IAI05_20850	COG1473	amidohydrolase
IAI05_20855	COG0583	DNA-binding transcription factor activity
IAI05_20860	COG0747	negative chemotaxis
IAI05_20870	COG0601	transmembrane transport
IAI05_20875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_20895	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_20905	COG0583	DNA-binding transcription factor activity
IAI05_20915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_20925	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IAI05_20940	COG2197	response regulator
IAI05_20945	COG4566	intracellular signal transduction
IAI05_20950	COG4191	Histidine kinase
IAI05_20970	COG2376	Dihydroxyacetone kinase
IAI05_20975	COG1522	sequence-specific DNA binding
IAI05_20995	COG0431	NADPH-dependent FMN reductase
IAI05_21005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_21015	COG4172	Belongs to the ABC transporter superfamily
IAI05_21020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_21040	COG0277	FAD linked oxidase domain protein
IAI05_21060	COG0778	Nitroreductase
IAI05_21090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAI05_21115	COG2318	DinB family
IAI05_21120	COG0583	DNA-binding transcription factor activity
IAI05_21135	COG1335	isochorismatase
IAI05_21160	COG3842	ATPase activity
IAI05_21165	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAI05_21170	COG1177	transmembrane transport
IAI05_21175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAI05_21185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IAI05_21200	COG1120	ATPase activity
IAI05_21205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_21210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_21215	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IAI05_21220	COG4774	siderophore transport
IAI05_21220	COG1629	transport
IAI05_21225	COG4702	Belongs to the UPF0303 family
IAI05_21245	COG1024	Enoyl-CoA hydratase
IAI05_21250	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_21255	COG1653	transport
IAI05_21260	COG1175	transmembrane transport
IAI05_21265	COG0395	ABC-type sugar transport system, permease component
IAI05_21270	COG3842	ATPase activity
IAI05_21285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IAI05_21295	COG3474	cytochrome
IAI05_21300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAI05_21305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IAI05_21310	COG1845	cytochrome c oxidase, subunit III
IAI05_21335	COG1136	(ABC) transporter
IAI05_21335	COG0577	efflux transmembrane transporter activity
IAI05_21390	COG3842	ATPase activity
IAI05_21400	COG1177	transmembrane transport
IAI05_21405	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAI05_21420	COG1940	carbohydrate kinase activity
IAI05_21440	COG1069	ribulokinase activity
IAI05_21445	COG1349	DNA-binding transcription factor activity
IAI05_21450	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_21475	COG0395	ABC-type sugar transport system, permease component
IAI05_21485	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_21495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAI05_21500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAI05_21510	COG0477	Major facilitator Superfamily
IAI05_21520	COG0405	Gamma-glutamyltransferase
IAI05_21550	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IAI05_21560	COG1733	regulation of RNA biosynthetic process
IAI05_21595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAI05_21600	COG3938	Belongs to the proline racemase family
IAI05_21605	COG4176	ABC-type proline glycine betaine transport system permease component
IAI05_21610	COG4176	ABC-type proline glycine betaine transport system permease component
IAI05_21615	COG3448	diguanylate cyclase activity
IAI05_21615	COG4175	Glycine betaine
IAI05_21625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_21630	COG1012	belongs to the aldehyde dehydrogenase family
IAI05_21635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_21645	COG0047	phosphoribosylformylglycinamidine synthase activity
IAI05_21650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_21660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAI05_21660	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAI05_21670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAI05_21685	COG1309	transcriptional regulator
IAI05_21700	COG1136	(ABC) transporter
IAI05_21715	COG1063	alcohol dehydrogenase
IAI05_21725	COG1879	ABC-type sugar transport system periplasmic component
IAI05_21735	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_21755	COG0477	Major facilitator Superfamily
IAI05_21895	COG5001	Diguanylate cyclase
IAI05_21895	COG3300	MHYT domain
IAI05_21920	COG1253	flavin adenine dinucleotide binding
IAI05_21935	COG3842	ATPase activity
IAI05_21940	COG0395	ABC-type sugar transport system, permease component
IAI05_21945	COG1175	transmembrane transport
IAI05_21950	COG1653	transport
IAI05_21960	COG0673	inositol 2-dehydrogenase activity
IAI05_21965	COG1609	Transcriptional regulator
IAI05_21975	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_21980	COG0583	DNA-binding transcription factor activity
IAI05_21990	COG1879	ABC-type sugar transport system periplasmic component
IAI05_21995	COG1129	ABC transporter
IAI05_22000	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_22005	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_22010	COG1609	Transcriptional regulator
IAI05_22020	COG0673	inositol 2-dehydrogenase activity
IAI05_22080	COG0714	Associated with various cellular activities
IAI05_22085	COG3256	nitric oxide reductase
IAI05_22120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IAI05_22125	COG3189	MarR family transcriptional regulator
IAI05_22135	COG0826	peptidase U32
IAI05_22170	COG4459	periplasmic nitrate reductase
IAI05_22185	COG0243	molybdopterin cofactor binding
IAI05_22195	COG3005	denitrification pathway
IAI05_22200	COG0583	DNA-binding transcription factor activity
IAI05_22210	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
IAI05_22215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_22230	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_22235	COG1535	isochorismatase
IAI05_22235	COG3433	isochorismatase activity
IAI05_22240	COG1021	2,3-dihydroxybenzoate-AMP ligase
IAI05_22245	COG1169	isochorismate synthase
IAI05_22255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAI05_22255	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IAI05_22260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAI05_22270	COG2375	cellular response to nickel ion
IAI05_22280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_22285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_22290	COG1120	ATPase activity
IAI05_22295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAI05_22305	COG1629	transport
IAI05_22305	COG4774	siderophore transport
IAI05_22310	COG1960	acyl-CoA dehydrogenase activity
IAI05_22315	COG0583	DNA-binding transcription factor activity
IAI05_22320	COG1609	Transcriptional regulator
IAI05_22330	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAI05_22350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IAI05_22355	COG0583	DNA-binding transcription factor activity
IAI05_22360	COG2814	Major facilitator Superfamily
IAI05_22365	COG1473	amidohydrolase
IAI05_22370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAI05_22380	COG0747	negative chemotaxis
IAI05_22385	COG0601	transmembrane transport
IAI05_22390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_22395	COG0444	Belongs to the ABC transporter superfamily
IAI05_22400	COG4608	Belongs to the ABC transporter superfamily
IAI05_22405	COG0583	DNA-binding transcription factor activity
IAI05_22410	COG0747	negative chemotaxis
IAI05_22415	COG0601	transmembrane transport
IAI05_22420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_22425	COG0154	amidase activity
IAI05_22430	COG0693	protein deglycase activity
IAI05_22440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_22445	COG0601	transmembrane transport
IAI05_22455	COG1473	amidohydrolase
IAI05_22460	COG4172	Belongs to the ABC transporter superfamily
IAI05_22465	COG2390	Transcriptional regulator
IAI05_22475	COG1175	transmembrane transport
IAI05_22480	COG0395	ABC-type sugar transport system, permease component
IAI05_22530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAI05_22540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAI05_22545	COG1414	Transcriptional regulator
IAI05_22550	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_22560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAI05_22565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAI05_22570	COG1121	(ABC) transporter
IAI05_22575	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAI05_22590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAI05_22595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAI05_22600	COG0471	metal ion transport
IAI05_22600	COG3273	potassium ion transport
IAI05_22605	COG2827	Endonuclease containing a URI domain
IAI05_22610	COG1253	flavin adenine dinucleotide binding
IAI05_22615	COG1309	transcriptional regulator
IAI05_22635	COG1609	Transcriptional regulator
IAI05_22640	COG1070	Carbohydrate kinase
IAI05_22645	COG2115	Belongs to the xylose isomerase family
IAI05_22655	COG0778	Nitroreductase
IAI05_22660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAI05_22665	COG2011	ABC-type metal ion transport system permease component
IAI05_22675	COG5001	Diguanylate cyclase
IAI05_22675	COG3300	MHYT domain
IAI05_22680	COG1054	Belongs to the UPF0176 family
IAI05_22690	COG2954	triphosphatase activity
IAI05_22695	COG0800	Aldolase
IAI05_22715	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IAI05_22755	COG0523	cobalamin synthesis protein
IAI05_22765	COG1846	Transcriptional regulator
IAI05_22770	COG1609	Transcriptional regulator
IAI05_22775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAI05_22785	COG3718	enzyme involved in inositol metabolism
IAI05_22795	COG3962	Belongs to the TPP enzyme family
IAI05_22800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_22815	COG0411	ABC transporter
IAI05_22830	COG0683	leucine binding
IAI05_22845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_22855	COG0747	negative chemotaxis
IAI05_22885	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IAI05_22890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAI05_22895	COG1126	abc transporter atp-binding protein
IAI05_22900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_22905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_22910	COG0765	amino acid transport
IAI05_22915	COG0765	amino acid transport
IAI05_22920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAI05_22925	COG3485	protocatechuate 3,4-dioxygenase
IAI05_22930	COG3485	protocatechuate 3,4-dioxygenase
IAI05_22935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IAI05_22945	COG0583	DNA-binding transcription factor activity
IAI05_22960	COG1414	Transcriptional regulator
IAI05_22970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IAI05_22975	COG0183	Belongs to the thiolase family
IAI05_22980	COG1609	Transcriptional regulator
IAI05_22995	COG1082	Xylose isomerase domain protein TIM barrel
IAI05_23000	COG0673	inositol 2-dehydrogenase activity
IAI05_23010	COG1609	Transcriptional regulator
IAI05_23015	COG0395	ABC-type sugar transport system, permease component
IAI05_23020	COG1175	transmembrane transport
IAI05_23025	COG3842	ATPase activity
IAI05_23035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IAI05_23055	COG2814	Major facilitator Superfamily
IAI05_23060	COG4774	siderophore transport
IAI05_23065	COG3712	iron ion homeostasis
IAI05_23075	COG1940	carbohydrate kinase activity
IAI05_23080	COG0584	glycerophosphoryl diester phosphodiesterase
IAI05_23085	COG0300	oxidoreductase activity
IAI05_23100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IAI05_23120	COG0667	Aldo Keto reductase
IAI05_23125	COG0583	DNA-binding transcription factor activity
IAI05_23135	COG1132	(ABC) transporter
IAI05_23155	COG2264	protein methyltransferase activity
IAI05_23160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAI05_23175	COG0463	Glycosyl transferase, family 2
IAI05_23195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IAI05_23205	COG4106	trans-aconitate 2-methyltransferase activity
IAI05_23210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IAI05_23215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IAI05_23225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IAI05_23230	COG1091	dTDP-4-dehydrorhamnose reductase activity
IAI05_23235	COG1088	dTDP-glucose 4,6-dehydratase activity
IAI05_23240	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IAI05_23255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_23260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_23265	COG1120	ATPase activity
IAI05_23270	COG4774	siderophore transport
IAI05_23275	COG0210	DNA helicase
IAI05_23285	COG1609	Transcriptional regulator
IAI05_23290	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAI05_23290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAI05_23305	COG0395	ABC-type sugar transport system, permease component
IAI05_23310	COG3842	ATPase activity
IAI05_23320	COG0444	Belongs to the ABC transporter superfamily
IAI05_23325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_23330	COG0601	transmembrane transport
IAI05_23335	COG2186	Transcriptional regulator
IAI05_23355	COG3300	MHYT domain
IAI05_23355	COG5001	Diguanylate cyclase
IAI05_23360	COG1028	Short-chain dehydrogenase reductase Sdr
IAI05_23370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAI05_23380	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IAI05_23385	COG0306	phosphate transporter
IAI05_23390	COG1392	Phosphate transport regulator
IAI05_23405	COG1566	PFAM secretion protein HlyD family protein
IAI05_23410	COG0745	RESPONSE REGULATOR receiver
IAI05_23415	COG2205	protein histidine kinase activity
IAI05_23430	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
IAI05_23445	COG4774	siderophore transport
IAI05_23455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_23460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAI05_23465	COG1120	ATPase activity
IAI05_23470	COG0583	DNA-binding transcription factor activity
IAI05_23480	COG3119	arylsulfatase activity
IAI05_23485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAI05_23490	COG3842	ATPase activity
IAI05_23495	COG0165	Argininosuccinate lyase
IAI05_23500	COG0395	ABC-type sugar transport system, permease component
IAI05_23505	COG1175	transmembrane transport
IAI05_23510	COG2182	Extracellular solute-binding protein
IAI05_23515	COG1940	carbohydrate kinase activity
IAI05_23540	COG1486	melibiose metabolic process
IAI05_23545	COG0747	negative chemotaxis
IAI05_23550	COG0601	transmembrane transport
IAI05_23555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_23560	COG4172	Belongs to the ABC transporter superfamily
IAI05_23565	COG1486	melibiose metabolic process
IAI05_23570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IAI05_23575	COG0842	Transport permease protein
IAI05_23575	COG1129	ABC transporter
IAI05_23580	COG0842	Transport permease protein
IAI05_23595	COG0784	Response regulator, receiver
IAI05_23600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAI05_23610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_23615	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IAI05_23630	COG0765	amino acid transport
IAI05_23640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAI05_23650	COG3938	Belongs to the proline racemase family
IAI05_23665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAI05_23670	COG0765	amino acid transport
IAI05_23675	COG0765	amino acid transport
IAI05_23685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAI05_23700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAI05_23720	COG3383	formate dehydrogenase (NAD+) activity
IAI05_23730	COG2223	nitrite transmembrane transporter activity
IAI05_23735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAI05_23745	COG2186	Transcriptional regulator
IAI05_23750	COG0747	negative chemotaxis
IAI05_23755	COG0601	transmembrane transport
IAI05_23760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_23765	COG4172	Belongs to the ABC transporter superfamily
IAI05_23770	COG4948	Mandelate Racemase Muconate Lactonizing
IAI05_23780	COG2186	Transcriptional regulator
IAI05_23785	COG0747	negative chemotaxis
IAI05_23790	COG0601	transmembrane transport
IAI05_23795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAI05_23800	COG0405	Gamma-glutamyltransferase
IAI05_23810	COG0483	inositol monophosphate 1-phosphatase activity
IAI05_23820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAI05_23845	COG3237	CsbD-like
IAI05_23855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IAI05_23860	COG3181	Tripartite tricarboxylate transporter family receptor
IAI05_23865	COG5265	(ABC) transporter
IAI05_23870	COG0488	(ABC) transporter
IAI05_23895	COG1049	propionate catabolic process, 2-methylcitrate cycle
IAI05_23900	COG0110	maltose O-acetyltransferase activity
IAI05_23910	COG1063	alcohol dehydrogenase
IAI05_23915	COG3284	Transcriptional regulator
IAI05_23935	COG1129	ABC transporter
IAI05_23940	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_23945	COG1172	Belongs to the binding-protein-dependent transport system permease family
IAI05_23955	COG0572	uridine kinase
IAI05_23960	COG1082	Xylose isomerase domain protein TIM barrel
IAI05_23985	COG4178	(ABC) transporter
IAI05_24020	COG0640	Transcriptional regulator