locus-tag class description CFBP6624_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CFBP6624_00010 ENOG4105CSA Coproporphyrinogen iii oxidase CFBP6624_00015 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CFBP6624_00020 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CFBP6624_00025 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CFBP6624_00030 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CFBP6624_00035 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN CFBP6624_00040 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea CFBP6624_00045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFBP6624_00050 ENOG4108IUZ ABC transporter CFBP6624_00055 ENOG4105RF0 OstA family CFBP6624_00065 ENOG4105D07 Signal peptide peptidase, SppA CFBP6624_00070 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CFBP6624_00085 ENOG4108RWN rrna methyltransferase CFBP6624_00090 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CFBP6624_00095 ENOG4105BZU Histidine kinase CFBP6624_00105 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CFBP6624_00110 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CFBP6624_00115 ENOG4105CJR Integral membrane protein (MviN CFBP6624_00120 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CFBP6624_00125 ENOG4105C31 Tryptophanyl-tRNA synthetase CFBP6624_00135 ENOG41083MR nifu domain-containing protein CFBP6624_00140 ENOG41072GX Peptidase M22 Glycoprotease CFBP6624_00150 ENOG41090R7 Ferric uptake CFBP6624_00155 ENOG4108Z20 Acyl-transferase CFBP6624_00160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CFBP6624_00165 ENOG4105C9A Phoh family CFBP6624_00170 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CFBP6624_00180 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CFBP6624_00185 ENOG4108WRK Transcriptional regulator CFBP6624_00190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CFBP6624_00195 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CFBP6624_00200 ENOG4108RVA ribokinase CFBP6624_00205 ENOG4105CGY Dna recombination protein CFBP6624_00210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CFBP6624_00215 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CFBP6624_00220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CFBP6624_00225 ENOG4105K89 arsenate reductase CFBP6624_00235 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CFBP6624_00240 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CFBP6624_00260 ENOG4108ZNX Heat shock protein CFBP6624_00285 ENOG4105CAS nag kinase CFBP6624_00300 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CFBP6624_00305 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CFBP6624_00310 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CFBP6624_00320 ENOG4105C8Q Methyl-accepting chemotaxis CFBP6624_00345 ENOG4108IJ9 (ABC) transporter CFBP6624_00350 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CFBP6624_00355 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CFBP6624_00370 ENOG4105CYC Transferase CFBP6624_00380 ENOG4105CTU Proline racemase CFBP6624_00385 ENOG4105EKE dihydroorotase CFBP6624_00390 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CFBP6624_00410 ENOG4107QP8 phosphohexose isomerase CFBP6624_00415 ENOG4105CEY Amp-dependent synthetase and ligase CFBP6624_00420 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_00425 ENOG4107QKW extracellular solute-binding protein family 1 CFBP6624_00430 ENOG4107Z6A sulfate abc transporter permease CFBP6624_00435 ENOG4105E0K tonB-dependent siderophore receptor CFBP6624_00485 ENOG4105CSR polyphosphate kinase 2 CFBP6624_00490 ENOG4105BZU Histidine kinase CFBP6624_00495 ENOG4105PWN phosphate abc transporter CFBP6624_00500 ENOG4105C8U phosphate abc transporter CFBP6624_00510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_00515 ENOG4108UTW Plays a role in the regulation of phosphate uptake CFBP6624_00520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_00535 ENOG4105C8Y Acetylornithine aminotransferase CFBP6624_00540 ENOG4105DBV ornithine carbamoyltransferase CFBP6624_00545 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CFBP6624_00550 ENOG4105NWN ApaG protein CFBP6624_00560 ENOG4105DHP deoxycytidine triphosphate deaminase CFBP6624_00640 ENOG41088T4 Helicase IV CFBP6624_00685 ENOG4105CS6 Rhs element vgr protein CFBP6624_00695 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CFBP6624_00745 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CFBP6624_00760 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CFBP6624_00780 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CFBP6624_00785 ENOG4107QRT dEAD DEAH box helicase CFBP6624_00820 ENOG4105CSU acyl-Coa dehydrogenase CFBP6624_00825 ENOG4105CHU acetyl-coa acetyltransferase CFBP6624_00830 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CFBP6624_00870 ENOG4105KJM monovalent cation h antiporter subunit g CFBP6624_00875 ENOG4105W4C monovalent cation H antiporter subunit F CFBP6624_00880 ENOG4105SC1 monovalent cation H antiporter subunit E CFBP6624_00885 ENOG4107R4Z monovalent cation h antiporter subunit d CFBP6624_00890 ENOG4108ZE9 Monovalent cation H antiporter subunit C CFBP6624_00895 ENOG4105D65 subunit l CFBP6624_00905 ENOG4105UT3 Methyl-accepting chemotaxis CFBP6624_00915 ENOG4108VYJ response regulator receiver protein CFBP6624_00920 ENOG4105CBS Chea signal transduction histidine kinase CFBP6624_00925 ENOG4105BZU Histidine kinase CFBP6624_00930 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CFBP6624_00935 ENOG4108VYJ response regulator receiver protein CFBP6624_00940 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CFBP6624_00950 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CFBP6624_00955 ENOG4105VJY transcriptional regulator CFBP6624_00970 ENOG4105BZU Histidine kinase CFBP6624_00980 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CFBP6624_00985 ENOG4105CHM Aminotransferase CFBP6624_01000 ENOG41086Q3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CFBP6624_01005 ENOG4108Z03 MAF-like protein CFBP6624_01010 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CFBP6624_01020 ENOG4108ZTZ UPF0262 protein CFBP6624_01025 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CFBP6624_01035 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CFBP6624_01050 ENOG4107W75 Flagellin CFBP6624_01070 ENOG4105CN7 Flagellar biosynthetic protein FliP CFBP6624_01080 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) CFBP6624_01090 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) CFBP6624_01095 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA CFBP6624_01100 ENOG4105CGA flagellar basal-body rod protein FlgG CFBP6624_01105 ENOG4105X50 flagellar hook-basal body complex protein fliE CFBP6624_01110 ENOG4108ZC9 flagellar basal-body rod protein flgc CFBP6624_01115 ENOG4105SFI flagellar basal-body rod protein CFBP6624_01125 ENOG4108JIR Flagellum-specific ATP synthase CFBP6624_01130 ENOG4105KTQ flagellar basal-body rod protein CFBP6624_01140 ENOG4107RD7 Flagellar Motor Protein, MotA CFBP6624_01150 ENOG4105DD5 Flagellar motor switch protein CFBP6624_01155 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CFBP6624_01160 ENOG4105D00 flagellar biosynthetic protein flhB CFBP6624_01165 ENOG4105QDQ CFBP6624_01175 ENOG4107W75 Flagellin CFBP6624_01185 ENOG4105ER2 Ompa motb domain protein CFBP6624_01190 ENOG4108S15 chemotaxis, protein CFBP6624_01210 ENOG4105BZE flagellar hook protein, FlgE CFBP6624_01230 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) CFBP6624_01235 ENOG410822I Flagellar hook capping protein CFBP6624_01240 ENOG4105VS8 Flagellar biosynthetic protein fliq CFBP6624_01245 ENOG4105D7B Flagellar biosynthesis protein flha CFBP6624_01250 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CFBP6624_01285 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CFBP6624_01290 ENOG4105FKQ transcriptional regulator CFBP6624_01295 ENOG4105EPJ extracellular solute-binding protein family 1 CFBP6624_01300 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component CFBP6624_01305 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CFBP6624_01310 ENOG4105CG3 alpha amylase, catalytic region CFBP6624_01315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_01325 ENOG4105X54 addiction module antidote protein CFBP6624_01340 ENOG4105C01 Dihydroxy-acid dehydratase CFBP6624_01345 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) CFBP6624_01350 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CFBP6624_01355 ENOG4105CJP fad dependent oxidoreductase CFBP6624_01365 ENOG4105CBX hi0933 family CFBP6624_01400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_01405 ENOG4105F38 ABC transporter, permease CFBP6624_01410 ENOG4105D38 putrescine abc transporter CFBP6624_01425 ENOG4105BZU Histidine kinase CFBP6624_01435 ENOG4105C9X ppx gppa phosphatase CFBP6624_01440 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) CFBP6624_01445 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFBP6624_01485 ENOG4108RIR Molybdenum cofactor biosynthesis protein CFBP6624_01490 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CFBP6624_01500 ENOG4105EAH synthase CFBP6624_01530 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CFBP6624_01540 ENOG4108V0P LemA family CFBP6624_01545 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CFBP6624_01555 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CFBP6624_01565 ENOG4105EWC Purine nucleoside phosphorylase CFBP6624_01570 ENOG4105C8Q Methyl-accepting chemotaxis CFBP6624_01580 ENOG4105C12 Phosphoribosylglycinamide synthetase CFBP6624_01585 ENOG4105BZM domain protein CFBP6624_01590 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CFBP6624_01635 ENOG4105CJ3 phosphate transporter CFBP6624_01645 ENOG4108E2B had-superfamily hydrolase, subfamily iib CFBP6624_01650 ENOG4107STW synthase CFBP6624_01655 ENOG4105C6F GntR Family Transcriptional Regulator CFBP6624_01670 ENOG410642W LysR family Transcriptional regulator CFBP6624_01675 ENOG4105CQB FAD linked oxidase domain protein CFBP6624_01685 ENOG4105CQB FAD linked oxidase domain protein CFBP6624_01690 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CFBP6624_01700 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_01705 ENOG4108R3E Dna-3-methyladenine glycosylase i CFBP6624_01715 ENOG4105HMI Membrane CFBP6624_01720 ENOG4108M0I Transcriptional regulator CFBP6624_01750 ENOG4105CUT histidyl-tRNA synthetase CFBP6624_01760 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit CFBP6624_01765 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CFBP6624_01770 ENOG4108SB3 DoxX Family CFBP6624_01785 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CFBP6624_01790 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CFBP6624_01800 ENOG4105DTN riboflavin biosynthesis protein ribF CFBP6624_01805 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CFBP6624_01815 ENOG4108Z6B deaminase CFBP6624_01820 ENOG4105FE9 pseudouridine synthase CFBP6624_01825 ENOG4106H78 methyltransferase CFBP6624_01830 ENOG4105D78 K07001 NTE family protein CFBP6624_01835 ENOG4105CKD glutathione-regulated potassium-efflux system protein CFBP6624_01840 ENOG4105CMS peptidase U62, modulator of DNA gyrase CFBP6624_01855 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CFBP6624_01870 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CFBP6624_01880 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CFBP6624_01885 ENOG4105BZU Histidine kinase CFBP6624_01890 ENOG4105BZU Histidine kinase CFBP6624_01895 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CFBP6624_01900 ENOG4108RTU Aldolase CFBP6624_01905 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CFBP6624_01910 ENOG4105FGE Short-chain dehydrogenase reductase Sdr CFBP6624_01920 ENOG4107WYG Transcriptional regulator, luxr family CFBP6624_01925 ENOG4105I5W Transporter CFBP6624_01930 ENOG4105D1F ATP-binding protein CFBP6624_01935 ENOG4107QUT magnesium and cobalt transport protein CorA CFBP6624_01940 ENOG4105DFH Transport of potassium into the cell (By similarity) CFBP6624_01950 ENOG4107PQ6 Inherit from NOG: atp synthase CFBP6624_01955 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CFBP6624_01960 ENOG4105VD1 ATP synthase subunit C CFBP6624_01965 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CFBP6624_01975 ENOG4108IG5 Transcriptional regulator CFBP6624_01980 ENOG4105E0T Short-chain dehydrogenase reductase Sdr CFBP6624_01985 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CFBP6624_02010 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CFBP6624_02020 ENOG4105DVW rieske (2Fe-2S) CFBP6624_02035 ENOG4105W6J BA14K family CFBP6624_02045 ENOG4105CSU acyl-Coa dehydrogenase CFBP6624_02060 ENOG4107QS4 23S rRNA CFBP6624_02065 ENOG4105DX0 Hemolysin A CFBP6624_02070 ENOG4105C8Q Methyl-accepting chemotaxis CFBP6624_02080 ENOG4108XM1 transcriptional regulator AsnC family CFBP6624_02105 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CFBP6624_02110 ENOG4105EUB pirin domain protein CFBP6624_02115 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CFBP6624_02125 ENOG4107ZYJ bioY protein CFBP6624_02130 ENOG4107QCX Transporter CFBP6624_02135 ENOG4108JJB ABC transporter CFBP6624_02140 ENOG4105T0Z Conserved Protein CFBP6624_02145 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CFBP6624_02150 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CFBP6624_02165 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CFBP6624_02170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CFBP6624_02180 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CFBP6624_02200 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 CFBP6624_02210 ENOG4105D1U peptidase U62 modulator of DNA gyrase CFBP6624_02220 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CFBP6624_02225 ENOG4105BZ9 Cytochrome C oxidase, subunit I CFBP6624_02230 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CFBP6624_02240 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) CFBP6624_02245 ENOG4107QS1 Cytochrome C Oxidase, Subunit III CFBP6624_02255 ENOG4108R6F Surfeit locus 1 family protein CFBP6624_02260 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CFBP6624_02265 ENOG4105CUV Homoserine Kinase CFBP6624_02270 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CFBP6624_02280 ENOG4105EHV domain protein CFBP6624_02290 ENOG4108UJU UPF0301 protein CFBP6624_02295 ENOG4108J08 Csbd family CFBP6624_02305 ENOG4105BZU Histidine kinase CFBP6624_02310 ENOG4105D9U N-acetyltransferase CFBP6624_02315 ENOG4105C1V Peptidase, M16 CFBP6624_02320 ENOG4105D98 threonine synthase CFBP6624_02330 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 CFBP6624_02335 ENOG4108PVQ transcriptional regulator CFBP6624_02355 ENOG4105CEC DNA methylase N-4 N-6 CFBP6624_02365 ENOG4105C0H protease CFBP6624_02375 ENOG4105CEN a g-specific adenine glycosylase CFBP6624_02390 ENOG4108R9S DSBA oxidoreductase CFBP6624_02395 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CFBP6624_02400 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CFBP6624_02405 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CFBP6624_02450 ENOG4105DWT malate dehydrogenase (quinone) CFBP6624_02475 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CFBP6624_02480 ENOG4105C11 sulfate adenylyltransferase), subunit 2 CFBP6624_02485 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CFBP6624_02490 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family CFBP6624_02495 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CFBP6624_02500 ENOG4108I5D sulfate abc transporter CFBP6624_02510 ENOG4108IJ6 ABC transporter CFBP6624_02535 ENOG4108NJZ Sensory box GGDEF EAL domain protein CFBP6624_02545 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) CFBP6624_02550 ENOG4105C26 Dehydrogenase CFBP6624_02555 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) CFBP6624_02570 ENOG4105CMQ Chloride channel CFBP6624_02600 ENOG4105C0R drug resistance transporter emrb qaca subfamily CFBP6624_02620 ENOG4107T0X DNA ligase CFBP6624_02630 ENOG4108ST3 glycosyltransferase CFBP6624_02640 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_02645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_02660 ENOG4105K56 Transcriptional regulator CFBP6624_02665 ENOG4108ZHJ Organic hydroperoxide resistance protein CFBP6624_02705 ENOG4105C5H ABC transporter CFBP6624_02720 ENOG4105D7A ATP-binding protein CFBP6624_02730 ENOG4105KVH Transcriptional regulator CFBP6624_02735 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CFBP6624_02750 ENOG4105CV8 reductase CFBP6624_02755 ENOG4105FFC UPF0187 protein CFBP6624_02760 ENOG4105D29 Helix-turn-helix type 11 domain protein CFBP6624_02770 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CFBP6624_02775 ENOG4105CM2 brancheD-chain amino acid aminotransferase CFBP6624_02780 ENOG4105C8Q Methyl-accepting chemotaxis CFBP6624_02785 ENOG4105DUM transcriptional regulator, lysR family CFBP6624_02800 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CFBP6624_02815 ENOG4108NIW Leucine export protein LeuE CFBP6624_02820 ENOG4105TAV cytochrome C CFBP6624_02825 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CFBP6624_02890 ENOG4108HQS Glycine betaine CFBP6624_02920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_02930 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CFBP6624_02940 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CFBP6624_02955 ENOG4105NHS Transcriptional regulator, TraR DksA family CFBP6624_02960 ENOG4108UT2 hemolysin iii CFBP6624_02970 ENOG4105E0X reductase CFBP6624_02975 ENOG4105D65 subunit l CFBP6624_02980 ENOG4105HC0 Na H antiporter CFBP6624_02985 ENOG4108ZE9 Monovalent cation H antiporter subunit C CFBP6624_02990 ENOG4108JPZ Monovalent cation H antiporter subunit D CFBP6624_02995 ENOG4105SC1 monovalent cation H antiporter subunit E CFBP6624_03000 ENOG41080TA Multiple resistance and ph regulation protein f CFBP6624_03005 ENOG4105KJM monovalent cation h antiporter subunit g CFBP6624_03010 ENOG4108YXV Transcriptional regulator CFBP6624_03025 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) CFBP6624_03030 ENOG4105WZR CFBP6624_03035 ENOG4105BZU Histidine kinase CFBP6624_03090 ENOG4108JQC penicillin-binding protein 1A CFBP6624_03095 ENOG4108ZZ3 UPF0260 protein CFBP6624_03155 ENOG4105CNG UPF0061 protein CFBP6624_03170 ENOG4105EW9 transcriptional regulator AsnC family CFBP6624_03320 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_03325 ENOG4105E0F Histidine kinase CFBP6624_03335 ENOG4106FI7 cytochrome c-type biogenesis protein CFBP6624_03340 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) CFBP6624_03345 ENOG4105DA4 cytochrome c-type biogenesis protein CFBP6624_03350 ENOG4105KWW Biogenesis protein CFBP6624_03355 ENOG4105C0H protease CFBP6624_03370 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CFBP6624_03380 ENOG4105Z4Q MltA-interacting MipA family protein CFBP6624_03385 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CFBP6624_03395 ENOG4105BZU Histidine kinase CFBP6624_03405 ENOG4105CD8 aminopeptidase N CFBP6624_03415 ENOG4108EHX EamA-like transporter family CFBP6624_03435 ENOG4105R8A Heat shock protein CFBP6624_03440 ENOG4105BZU Histidine kinase CFBP6624_03445 ENOG4105CHR reductase CFBP6624_03475 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CFBP6624_03490 ENOG4105KVH Transcriptional regulator CFBP6624_03495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CFBP6624_03500 ENOG4105CJW magnesium transporter CFBP6624_03505 ENOG4105F27 Major Facilitator CFBP6624_03515 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFBP6624_03530 ENOG4105FYV Amp nucleosidase CFBP6624_03555 ENOG4105CIH Imidazole acetol-phosphate transaminase CFBP6624_03605 ENOG4107SC1 transglycosylase CFBP6624_03610 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_03615 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CFBP6624_03635 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CFBP6624_03660 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CFBP6624_03665 ENOG4105C3F Signal peptidase i CFBP6624_03670 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CFBP6624_03675 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CFBP6624_03685 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CFBP6624_03690 ENOG41074H6 response regulator CFBP6624_03695 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) CFBP6624_03705 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CFBP6624_03715 ENOG4105EST Metal Dependent Phosphohydrolase CFBP6624_03725 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CFBP6624_03735 ENOG4105D7T ABC transporter CFBP6624_03740 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component CFBP6624_03745 ENOG4108MEK Metal-binding protein YodA CFBP6624_03750 ENOG4105D64 Mechanosensitive ion channel CFBP6624_03760 ENOG4108R7K Metal Dependent Phosphohydrolase CFBP6624_03785 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CFBP6624_03790 ENOG4105KK4 UPF0060 membrane protein CFBP6624_03800 ENOG4105BZU Histidine kinase CFBP6624_03810 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CFBP6624_03815 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme CFBP6624_03820 ENOG4108JJ7 ABC transporter CFBP6624_03830 ENOG4108URH decarboxylase CFBP6624_03840 ENOG4105FR1 rard protein CFBP6624_03865 ENOG4105WDY DNA (cytosine-5-)-methyltransferase CFBP6624_03875 ENOG4105C8N cysteinyl-tRNA synthetase CFBP6624_03880 ENOG4105PDP Short chain dehydrogenase CFBP6624_03885 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CFBP6624_03890 ENOG4105E96 Colicin v production protein CFBP6624_03910 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CFBP6624_03915 ENOG4105E7U AraC family transcriptional regulator CFBP6624_03920 ENOG4108UMN azlc family CFBP6624_03955 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CFBP6624_03965 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CFBP6624_03970 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CFBP6624_03980 ENOG4105CPC Aldo Keto reductase CFBP6624_03985 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CFBP6624_03995 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CFBP6624_04000 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CFBP6624_04005 ENOG4105HHA aminodeoxychorismate lyase CFBP6624_04010 ENOG4105DSJ YicC domain protein CFBP6624_04015 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CFBP6624_04020 ENOG4105FBA Phospholipase Carboxylesterase CFBP6624_04025 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CFBP6624_04030 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CFBP6624_04040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CFBP6624_04055 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CFBP6624_04065 ENOG4105BZU Histidine kinase CFBP6624_04080 ENOG4105BZU Histidine kinase CFBP6624_04085 ENOG4105BZU Histidine kinase CFBP6624_04100 ENOG4105C5H ABC transporter CFBP6624_04105 ENOG4105BZU Histidine kinase CFBP6624_04115 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CFBP6624_04135 ENOG4108ZAF Molybdopterin CFBP6624_04150 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CFBP6624_04155 ENOG4105CHR reductase CFBP6624_04160 ENOG4105JVC membrAne CFBP6624_04165 ENOG4108U78 Glutathione S-transferase CFBP6624_04190 ENOG4105D6S protein involved in catabolism of external DNA CFBP6624_04195 ENOG4107QY8 reductase CFBP6624_04200 ENOG4107VIJ nudix hydrolase CFBP6624_04205 ENOG4107VIJ nudix hydrolase CFBP6624_04220 ENOG4108V3E phosphoribosylglycinamide formyltransferase CFBP6624_04225 ENOG4105CXB phosphoribosylaminoimidazole synthetase CFBP6624_04235 ENOG4105C02 permease CFBP6624_04240 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CFBP6624_04245 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CFBP6624_04250 ENOG4105C9X ppx gppa phosphatase CFBP6624_04275 ENOG4108Q35 Adenylate CFBP6624_04285 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CFBP6624_04290 ENOG4108ISG Major Facilitator CFBP6624_04295 ENOG4105C9M aspartyl-trna synthetase CFBP6624_04300 ENOG4105CT7 inner membrane cred family protein CFBP6624_04310 ENOG4105CHH sulfate transporter CFBP6624_04320 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFBP6624_04325 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate CFBP6624_04340 ENOG4105D52 delta-aminolevulinic acid dehydratase CFBP6624_04365 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CFBP6624_04370 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CFBP6624_04375 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CFBP6624_04390 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CFBP6624_04395 ENOG4107XZX Involved in the transcription termination process (By similarity) CFBP6624_04400 ENOG4105DXI Major Facilitator superfamily CFBP6624_04405 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for CFBP6624_04425 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CFBP6624_04430 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CFBP6624_04435 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CFBP6624_04440 ENOG4105WJX transcriptional regulator MERR family CFBP6624_04470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_04475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_04480 ENOG4105C3U ABC transporter CFBP6624_04490 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_04500 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CFBP6624_04505 ENOG4105C7B Threonine dehydratase CFBP6624_04515 ENOG4105BZU Histidine kinase CFBP6624_04520 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CFBP6624_04525 ENOG4107653 Transcriptional regulator CFBP6624_04535 ENOG4105CGH 5'-nucleotidase CFBP6624_04565 ENOG4105KHC sulfurtransferase CFBP6624_04580 ENOG4105CVP deoxyribo-dipyrimidine photolyase CFBP6624_04590 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CFBP6624_04620 ENOG4108TPP exopolysaccharide synthesis CFBP6624_04625 ENOG4108UM1 dedA family CFBP6624_04675 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase CFBP6624_04700 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) CFBP6624_04710 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CFBP6624_04715 ENOG4105CYW agmatinase CFBP6624_04720 ENOG4106F59 XRE family Transcriptional regulator CFBP6624_04725 ENOG4105XUP Phage derived protein Gp49-like (DUF891) CFBP6624_04730 ENOG4108UJD 30S ribosomal protein S9 CFBP6624_04735 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CFBP6624_04745 ENOG4105K4P CoA-binding domain protein CFBP6624_04775 ENOG4105BZU Histidine kinase CFBP6624_04780 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CFBP6624_04785 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CFBP6624_04800 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CFBP6624_04835 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CFBP6624_04840 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CFBP6624_04845 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CFBP6624_04855 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CFBP6624_04865 ENOG4105GKE subunit e CFBP6624_04870 ENOG4107QIZ NADH dehydrogenase CFBP6624_04875 ENOG4107R0R NADH dehydrogenase subunit g CFBP6624_04880 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CFBP6624_04885 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CFBP6624_04890 ENOG4105DF2 NADH dehydrogenase subunit j CFBP6624_04895 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CFBP6624_04900 ENOG4105D65 subunit l CFBP6624_04905 ENOG4105C8S subunit m CFBP6624_04910 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CFBP6624_04930 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CFBP6624_04940 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CFBP6624_04950 ENOG4105C0B DNA polymerase III (alpha subunit) CFBP6624_04960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CFBP6624_04970 ENOG4108UXN response regulator CFBP6624_04975 ENOG4105BZU Histidine kinase CFBP6624_04985 ENOG4105W0E 50S ribosomal protein L33 CFBP6624_04990 ENOG4108ISG Major Facilitator CFBP6624_05005 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CFBP6624_05020 ENOG4105C79 DNA protecting protein DprA CFBP6624_05025 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CFBP6624_05030 ENOG4105CD3 dihydroorotase CFBP6624_05035 ENOG4105CXT aspartate transcarbamylase CFBP6624_05040 ENOG4105CSU acyl-Coa dehydrogenase CFBP6624_05045 ENOG4108ZBR Gcn5-related n-acetyltransferase CFBP6624_05060 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CFBP6624_05065 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CFBP6624_05070 ENOG4107T8T UPF0173 metal-dependent hydrolase CFBP6624_05075 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CFBP6624_05080 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CFBP6624_05085 ENOG4105YCT UPF0386 protein CFBP6624_05090 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CFBP6624_05100 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CFBP6624_05110 ENOG410849A acetyltransferase, (GNAT) family CFBP6624_05125 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CFBP6624_05130 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CFBP6624_05135 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CFBP6624_05140 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CFBP6624_05175 ENOG4105C03 ribonuclease CFBP6624_05185 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CFBP6624_05210 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CFBP6624_05215 ENOG4105JAB phenazine biosynthesis protein, phzf family CFBP6624_05230 ENOG4107Z7P Ferredoxin CFBP6624_05240 ENOG4105EEI dihydropteroate synthase CFBP6624_05245 ENOG4105KRF dihydroneopterin aldolase CFBP6624_05250 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CFBP6624_05260 ENOG4106K28 UPF0283 membrane protein CFBP6624_05265 ENOG4105CM6 amino acid regulated cytosolic protein CFBP6624_05275 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CFBP6624_05290 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CFBP6624_05315 ENOG4108MGI Transcriptional regulator CFBP6624_05325 ENOG4105K59 histidine triad (HIT) protein CFBP6624_05350 ENOG4105CE9 30S ribosomal protein S2 CFBP6624_05355 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CFBP6624_05360 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CFBP6624_05365 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CFBP6624_05370 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CFBP6624_05375 ENOG4105KNE Phosphatidate cytidylyltransferase CFBP6624_05380 ENOG4105DZP Membrane-associated zinc metalloprotease CFBP6624_05385 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CFBP6624_05390 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CFBP6624_05395 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CFBP6624_05400 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CFBP6624_05405 ENOG4105GYT Protein of unknown function (DUF1009) CFBP6624_05410 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CFBP6624_05415 ENOG4105BZN citrate synthase CFBP6624_05430 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CFBP6624_05440 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CFBP6624_05445 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CFBP6624_05455 ENOG4108JYK Dehydrogenase CFBP6624_05460 ENOG4105CPP Dehydrogenase, E1 component CFBP6624_05470 ENOG4105C7S Dehydrogenase CFBP6624_05480 ENOG4107QN2 dihydrolipoyl dehydrogenase CFBP6624_05490 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CFBP6624_05495 ENOG4105DXC membrane CFBP6624_05515 ENOG4108Z1B Cyclase dehydrase CFBP6624_05525 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CFBP6624_05535 ENOG4105CUX Signal transduction histidine kinase CFBP6624_05540 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CFBP6624_05545 ENOG4105ES5 Histidine kinase CFBP6624_05550 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CFBP6624_05555 ENOG4105C1A potassium transporter peripheral membrane CFBP6624_05560 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CFBP6624_05565 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CFBP6624_05570 ENOG4105DXN mazG family CFBP6624_05585 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CFBP6624_05605 ENOG4105DP0 ferredoxin-NADP reductase CFBP6624_05635 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CFBP6624_05640 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CFBP6624_05645 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CFBP6624_05670 ENOG41082CG Protein CrcB homolog CFBP6624_05675 ENOG4105EI2 Pseudouridine synthase CFBP6624_05680 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CFBP6624_05695 ENOG4108UQ8 endoribonuclease L-psp CFBP6624_05700 ENOG4105C4W S-formylglutathione hydrolase CFBP6624_05710 ENOG4108UPT UPF0178 protein CFBP6624_05725 ENOG4105D3R alkyl hydroperoxide reductase CFBP6624_05730 ENOG4107MKT Stringent starvation protein a CFBP6624_05735 ENOG4105EN6 Membrane CFBP6624_05775 ENOG4105F8V Hydrolase, tatD family CFBP6624_05780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CFBP6624_05785 ENOG4107QRG dna polymerase iii CFBP6624_05790 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CFBP6624_05795 ENOG4105DZ1 carboxypeptidase CFBP6624_05855 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFBP6624_05860 ENOG41081FY multiple antibiotic resistance (MarC)-related CFBP6624_05865 ENOG4105CJW magnesium transporter CFBP6624_05875 ENOG4108UUM single-stranded DNA-binding protein CFBP6624_05880 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CFBP6624_05890 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CFBP6624_05895 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CFBP6624_05900 ENOG4108Z0R Transferase CFBP6624_05910 ENOG4105FAV ABC, transporter CFBP6624_05915 ENOG4105FDK ABC transporter CFBP6624_05920 ENOG4105NXV High-affinity zinc uptake system protein CFBP6624_05925 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_05935 ENOG4105CPC Aldo Keto reductase CFBP6624_05945 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CFBP6624_06030 ENOG4105CJW magnesium transporter CFBP6624_06035 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CFBP6624_06045 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CFBP6624_06060 ENOG4105BZU Histidine kinase CFBP6624_06075 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CFBP6624_06080 ENOG4105DQ4 alcohol dehydrogenase CFBP6624_06120 ENOG4105E2A Dehydrogenase CFBP6624_06140 ENOG4105D7W serine acetyltransferase CFBP6624_06160 ENOG4105C28 cystathionine CFBP6624_06165 ENOG4107QXX ABC transporter CFBP6624_06170 ENOG4105EZ7 amino acid ABC transporter CFBP6624_06175 ENOG4105DRP amino acid AbC transporter CFBP6624_06180 ENOG4105CDA abc transporter atp-binding protein CFBP6624_06200 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CFBP6624_06210 ENOG4105D6E homoserine dehydrogenase CFBP6624_06215 ENOG4105CHM Aminotransferase CFBP6624_06245 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CFBP6624_06255 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CFBP6624_06260 ENOG4105J3Q acyl carrier protein CFBP6624_06265 ENOG4105D4P Coproporphyrinogen iii oxidase CFBP6624_06270 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CFBP6624_06280 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class CFBP6624_06285 ENOG4105PW4 Sugar fermentation stimulation protein homolog CFBP6624_06290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CFBP6624_06295 ENOG4105W5Q DNA repair protein (RadC CFBP6624_06310 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CFBP6624_06315 ENOG4105DC8 reductase CFBP6624_06325 ENOG4105E66 phosphoriboisomerase A CFBP6624_06330 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CFBP6624_06345 ENOG4105C9Q fumarate hydratase class II CFBP6624_06350 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CFBP6624_06355 ENOG4107EJC Preprotein translocase subunit SecG CFBP6624_06360 ENOG4105CP7 Triose-phosphate isomerase CFBP6624_06370 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFBP6624_06380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CFBP6624_06390 ENOG4105KBH arsR family transcriptional regulator CFBP6624_06395 ENOG4107RZC phospholipase d CFBP6624_06400 ENOG4108VYJ response regulator receiver protein CFBP6624_06425 ENOG4105EGS Mechanosensitive ion channel CFBP6624_06495 ENOG4105DHJ ABC, transporter CFBP6624_06500 ENOG4105CY3 ABC transporter, permease CFBP6624_06505 ENOG4107S8C mandelate racemase muconate lactonizing CFBP6624_06515 ENOG4105C6K Malic enzyme CFBP6624_06535 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CFBP6624_06540 ENOG4108MR6 WD40-like Beta Propeller Repeat CFBP6624_06555 ENOG4105C4K Nad synthetase CFBP6624_06560 ENOG4107T7U Sulfatase CFBP6624_06585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CFBP6624_06610 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CFBP6624_06630 ENOG4107QPD alcohol dehydrogenase CFBP6624_06670 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CFBP6624_06675 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CFBP6624_06680 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CFBP6624_06685 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CFBP6624_06690 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CFBP6624_06715 ENOG4108I0Q anthranilate phosphoribosyltransferase CFBP6624_06720 ENOG4105DK0 Indole-3-glycerol phosphate synthase CFBP6624_06725 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CFBP6624_06730 ENOG4105CVM Molybdenum cofactor synthesis domain protein CFBP6624_06735 ENOG4105BZU Histidine kinase CFBP6624_06745 ENOG4105CKD glutathione-regulated potassium-efflux system protein CFBP6624_06755 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CFBP6624_06765 ENOG4105CZQ inner membrane transport protein YdhC CFBP6624_06770 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CFBP6624_06775 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b CFBP6624_06780 ENOG4105DR5 peptidase CFBP6624_06785 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CFBP6624_06790 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CFBP6624_06795 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CFBP6624_06800 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CFBP6624_06810 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CFBP6624_06815 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CFBP6624_06820 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CFBP6624_06825 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CFBP6624_06835 ENOG4105C75 arginyL-tRNA synthetase CFBP6624_06840 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CFBP6624_06845 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CFBP6624_06855 ENOG4108UQD Sel1 domain protein repeat-containing protein CFBP6624_06870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CFBP6624_06880 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CFBP6624_06910 ENOG4105CS1 NAD(P)H quinone oxidoreductase CFBP6624_06915 ENOG4107TH8 cina domain protein CFBP6624_06925 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CFBP6624_06935 ENOG4107RTZ reductase CFBP6624_06950 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CFBP6624_06965 ENOG4105BZ1 (ABC) transporter CFBP6624_06970 ENOG4105IPI Membrane CFBP6624_07005 ENOG4105C22 threonyL-tRNA synthetase CFBP6624_07015 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CFBP6624_07025 ENOG4105EUJ GTP cyclohydrolase i CFBP6624_07030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CFBP6624_07035 ENOG4105D78 K07001 NTE family protein CFBP6624_07045 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CFBP6624_07075 ENOG4105EJQ L-serine dehydratase CFBP6624_07120 ENOG4105ECQ AraC Family Transcriptional Regulator CFBP6624_07140 ENOG4105FA0 parb-like partition protein CFBP6624_07180 ENOG4105IKI host-nuclease inhibitor protein CFBP6624_07235 ENOG4108HMX isocitrate dehydrogenase (NADP) CFBP6624_07245 ENOG4108QUU Morphogenesis Protein CFBP6624_07380 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CFBP6624_07395 ENOG4105C5F glutamine synthetase CFBP6624_07405 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) CFBP6624_07425 ENOG4108JHT EamA-like transporter family CFBP6624_07450 ENOG4105CB5 ATP-dependent DNA helicase recG CFBP6624_07475 ENOG41080VW acetyltransferase CFBP6624_07480 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CFBP6624_07485 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CFBP6624_07490 ENOG4107EJG GntR family transcriptional regulator CFBP6624_07505 ENOG4105UIB (ABC) transporter CFBP6624_07510 ENOG4105C2J ABC transporter CFBP6624_07515 ENOG4105VE1 Phosphatidylcholine synthase CFBP6624_07520 ENOG41061H0 Monooxygenase CFBP6624_07525 ENOG4105RK9 auxin efflux carrier CFBP6624_07530 ENOG4107QIV Cytochrome c biogenesis protein CFBP6624_07565 ENOG4105VEQ Cold shock protein CFBP6624_07630 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CFBP6624_07655 ENOG4105D6J arsenicaL-resistance protein CFBP6624_07665 ENOG4105CAU Arsenical resistance protein, ArsH CFBP6624_07690 ENOG4105W39 Membrane CFBP6624_07700 ENOG41061MD high-affinity nickel-transporter CFBP6624_07780 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CFBP6624_07785 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CFBP6624_07805 ENOG4105QAS Iron-sulfur cluster assembly accessory protein CFBP6624_07810 ENOG4105VG1 fes assembly suf system protein CFBP6624_07820 ENOG4105JRK feS assembly protein SufD CFBP6624_07840 ENOG4105C3J Cysteine desulfurase CFBP6624_07845 ENOG4105DHZ alpha beta CFBP6624_07855 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CFBP6624_07860 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CFBP6624_07870 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CFBP6624_07875 ENOG4105ED9 Protein of unknown function (DUF455) CFBP6624_07880 ENOG4105DR5 peptidase CFBP6624_07885 ENOG4105C1J atp-dependent rna helicase CFBP6624_07900 ENOG4105DJV ribulose-phosphate 3-epimerase CFBP6624_07910 ENOG4105C83 adenylosuccinate lyase CFBP6624_07920 ENOG4107QPR SAICAR synthetase CFBP6624_07925 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CFBP6624_07930 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CFBP6624_07945 ENOG4107SQD Transcriptional regulator, GntR family CFBP6624_07950 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CFBP6624_07980 ENOG4105C2C drug resistance transporter, Bcr CflA CFBP6624_07985 ENOG4105ECY inositol monophosphatase CFBP6624_07990 ENOG4108MWI inositol mono-phosphatase CFBP6624_07995 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CFBP6624_08000 ENOG4105CSV Glutaminase CFBP6624_08005 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CFBP6624_08010 ENOG4105DU1 integral membrane protein, terc CFBP6624_08020 ENOG4108594 Permease of the drug metabolite transporter CFBP6624_08025 ENOG410829K Lysine exporter protein (Lyse ygga) CFBP6624_08040 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CFBP6624_08045 ENOG4105CVS RNA methyltransferase TrmH family, group 1 CFBP6624_08070 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CFBP6624_08080 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CFBP6624_08085 ENOG4107UH8 sugar kinase CFBP6624_08090 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) CFBP6624_08105 ENOG4106TNF Periplasmic binding protein CFBP6624_08110 ENOG4105GBT ABC transporter CFBP6624_08120 ENOG4105P0T Usg family CFBP6624_08130 ENOG4108XM1 transcriptional regulator AsnC family CFBP6624_08135 ENOG4108RG0 uracil-dna glycosylase CFBP6624_08145 ENOG4105BZU Histidine kinase CFBP6624_08155 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CFBP6624_08160 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CFBP6624_08175 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CFBP6624_08180 ENOG4108R85 Short chain dehydrogenase CFBP6624_08190 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_08195 ENOG4105CNN ABC, transporter CFBP6624_08200 ENOG4108HHA Transketolase CFBP6624_08205 ENOG4108IUS Transketolase CFBP6624_08210 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CFBP6624_08215 ENOG4107RHR regulatoR CFBP6624_08225 ENOG4105E3A (ABC) transporter CFBP6624_08230 ENOG4105DA5 (ABC) transporter CFBP6624_08250 ENOG41080BE Methyl-accepting chemotaxis sensory transducer CFBP6624_08260 ENOG4105D1H recombination factor protein RarA CFBP6624_08265 ENOG4105C0H protease CFBP6624_08280 ENOG4105C01 Dihydroxy-acid dehydratase CFBP6624_08285 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) CFBP6624_08290 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) CFBP6624_08300 ENOG4105NX3 Membrane CFBP6624_08305 ENOG4108ZT0 50S ribosomal protein l17 CFBP6624_08310 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFBP6624_08315 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CFBP6624_08320 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CFBP6624_08325 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CFBP6624_08330 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CFBP6624_08335 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CFBP6624_08340 ENOG41084HQ 50S ribosomal protein L30 CFBP6624_08345 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CFBP6624_08350 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CFBP6624_08355 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CFBP6624_08360 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CFBP6624_08365 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CFBP6624_08370 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CFBP6624_08375 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CFBP6624_08380 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CFBP6624_08385 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CFBP6624_08390 ENOG41083MP 50s ribosomal protein l29 CFBP6624_08395 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CFBP6624_08400 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CFBP6624_08405 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CFBP6624_08410 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CFBP6624_08415 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CFBP6624_08420 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CFBP6624_08425 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CFBP6624_08430 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CFBP6624_08435 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CFBP6624_08440 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CFBP6624_08445 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CFBP6624_08450 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CFBP6624_08455 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CFBP6624_08475 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFBP6624_08480 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CFBP6624_08485 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CFBP6624_08490 ENOG4108VZM 50s ribosomal protein L10 CFBP6624_08495 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CFBP6624_08500 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CFBP6624_08525 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CFBP6624_08530 ENOG4108ZCF integral membrane protein CFBP6624_08560 ENOG4105BZ1 (ABC) transporter CFBP6624_08575 ENOG4105C2N RNA methyltransferase TrmH family group 3 CFBP6624_08580 ENOG4105NAU thioesterase Superfamily protein CFBP6624_08605 ENOG4108RYK Nad-dependent epimerase dehydratase CFBP6624_08610 ENOG4105KVH Transcriptional regulator CFBP6624_08615 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CFBP6624_08625 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CFBP6624_08635 ENOG4105DYC esterase CFBP6624_08655 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CFBP6624_08665 ENOG4108KU3 Integrase CFBP6624_08790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_08800 ENOG4107QKW extracellular solute-binding protein family 1 CFBP6624_08805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CFBP6624_08810 ENOG4105NWF RbsD or FucU transport CFBP6624_08820 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CFBP6624_08830 ENOG4105CF7 AraC family transcriptional regulator CFBP6624_08835 ENOG4105DQ4 alcohol dehydrogenase CFBP6624_08840 ENOG4105CEP NADH dehydrogenase CFBP6624_08845 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CFBP6624_08850 ENOG4105VJY transcriptional regulator CFBP6624_08855 ENOG4107SID ATP-dependent exodnase (exonuclease v) CFBP6624_08860 ENOG4105CGD Nad-dependent epimerase dehydratase CFBP6624_08900 ENOG4105CV8 reductase CFBP6624_08915 ENOG4108ZP8 Acetolactate synthase small subunit CFBP6624_08920 ENOG4105C7K acetolactate synthase CFBP6624_08930 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CFBP6624_08935 ENOG4105EAC phosphoserine phosphatase CFBP6624_08940 ENOG4108YYQ gCN5-related N-acetyltransferase CFBP6624_08945 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFBP6624_08955 ENOG4105EPW hflc protein CFBP6624_08960 ENOG4107QJR hflk protein CFBP6624_08970 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CFBP6624_09010 ENOG4105CQB FAD linked oxidase domain protein CFBP6624_09015 ENOG4105BZS acriflavin resistance protein CFBP6624_09020 ENOG4105ENT Efflux transporter rnd family, mfp subunit CFBP6624_09050 ENOG4105EV9 Alpha Beta Hydrolase CFBP6624_09070 ENOG4108RWI nicotinamidase CFBP6624_09100 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CFBP6624_09105 ENOG4108ZX6 Electron transport protein SCO1 SenC CFBP6624_09110 ENOG4108V3W Chemotaxis protein, CheW CFBP6624_09125 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_09135 ENOG4105WCN acetyltransferase CFBP6624_09145 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CFBP6624_09155 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CFBP6624_09160 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CFBP6624_09165 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CFBP6624_09170 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CFBP6624_09175 ENOG4108UFP Essential cell division protein (By similarity) CFBP6624_09180 ENOG4105CPF Cell wall formation (By similarity) CFBP6624_09185 ENOG4105CSH Transporter CFBP6624_09195 ENOG4105D4A Cell wall formation (By similarity) CFBP6624_09200 ENOG4105DFU Cell wall formation (By similarity) CFBP6624_09205 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CFBP6624_09215 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CFBP6624_09220 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CFBP6624_09230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CFBP6624_09245 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CFBP6624_09250 ENOG4107YUR Cell division protein mraZ CFBP6624_09260 ENOG4105E1F short-chain dehydrogenase reductase CFBP6624_09265 ENOG4107YPT transcriptional regulator CFBP6624_09290 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CFBP6624_09295 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) CFBP6624_09320 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CFBP6624_09335 ENOG4105SYT Methylenetetrahydrofolate reductase CFBP6624_09350 ENOG4105E5G Alpha beta hydrolase fold CFBP6624_09355 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CFBP6624_09370 ENOG4105M4H endoribonuclease L-psp CFBP6624_09385 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CFBP6624_09390 ENOG4105EQ0 Major Facilitator superfamily CFBP6624_09415 ENOG4105C26 Dehydrogenase CFBP6624_09420 ENOG4105C5F glutamine synthetase CFBP6624_09425 ENOG4105CUB amino acid CFBP6624_09435 ENOG4105QEK Transcriptional regulator CFBP6624_09460 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_09480 ENOG4105CSH Transporter CFBP6624_09485 ENOG4105C3R Methionine synthase CFBP6624_09490 ENOG4107QKS N-acylglucosamine 2-epimerase CFBP6624_09520 ENOG4105MPN Membrane CFBP6624_09535 ENOG4105BZU Histidine kinase CFBP6624_09550 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFBP6624_09555 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CFBP6624_09575 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CFBP6624_09580 ENOG4107QI1 Mate efflux family protein CFBP6624_09585 ENOG4105C8Q Methyl-accepting chemotaxis CFBP6624_09595 ENOG4105CGZ zinc metallopeptidase CFBP6624_09610 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CFBP6624_09625 ENOG4105BZU Histidine kinase CFBP6624_09630 ENOG4108UN4 phage SPO1 DNA polymerase-related protein CFBP6624_09640 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CFBP6624_09650 ENOG4105F7P transcriptional regulator AsnC family CFBP6624_09655 ENOG4105C3M thioredoxin reductase CFBP6624_09660 ENOG4105CBN LysR family transcriptional regulator CFBP6624_09670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CFBP6624_09700 ENOG4105EWV Sodium calcium exchanger membrane region CFBP6624_09705 ENOG4105CHM Aminotransferase CFBP6624_09710 ENOG4108KMM Diguanylate cyclase CFBP6624_09735 ENOG4105C5X domain protein CFBP6624_09750 ENOG41090HR transcriptional regulator CFBP6624_09755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CFBP6624_09760 ENOG4105E0F Histidine kinase CFBP6624_09765 ENOG4108Z7R Chaperone CsaA CFBP6624_09770 ENOG4105II7 pyrroline-5-carboxylate reductase CFBP6624_09785 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CFBP6624_09795 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CFBP6624_09810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CFBP6624_09830 ENOG4105CKK Glycosyl transferase, family 2 CFBP6624_09840 ENOG4105C26 Dehydrogenase CFBP6624_09845 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CFBP6624_09850 ENOG4105BZU Histidine kinase CFBP6624_09855 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CFBP6624_09870 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CFBP6624_09880 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CFBP6624_09885 ENOG4105C3G gtp-binding protein CFBP6624_09905 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CFBP6624_09910 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CFBP6624_09920 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CFBP6624_09930 ENOG4105BZ1 (ABC) transporter CFBP6624_09940 ENOG4105BZ1 (ABC) transporter CFBP6624_09950 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CFBP6624_09955 ENOG4105EAM Na Pi-cotransporter CFBP6624_09965 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CFBP6624_09980 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CFBP6624_09985 ENOG4105M6F mutator MutT protein CFBP6624_09995 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CFBP6624_10015 ENOG4105VEV -acetyltransferase CFBP6624_10035 ENOG41079KZ Major Facilitator Superfamily CFBP6624_10045 ENOG4105CHF Glutathione S-transferase CFBP6624_10050 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CFBP6624_10060 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CFBP6624_10075 ENOG4105DKK Benzoate CFBP6624_10100 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CFBP6624_10115 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CFBP6624_10140 ENOG41080HT Transcriptional regulator, arsr family CFBP6624_10145 ENOG4108IJ7 Glycine betaine CFBP6624_10160 ENOG4107104 thymidine kinase CFBP6624_10180 ENOG4108TEB UPF0114 protein CFBP6624_10195 ENOG4105CRQ synthase (Component I) CFBP6624_10205 ENOG4105CPI Metal Dependent Phosphohydrolase CFBP6624_10210 ENOG4105CPN adenine deaminase CFBP6624_10225 ENOG4105CG3 alpha amylase, catalytic region CFBP6624_10230 ENOG4107SS6 2-dehydro-3-deoxygluconokinase CFBP6624_10250 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CFBP6624_10280 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CFBP6624_10310 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_10325 ENOG4107QUY Guanine deaminase CFBP6624_10340 ENOG4105DMF Dehydrogenase CFBP6624_10350 ENOG4108RZE Tetr family transcriptional regulator CFBP6624_10355 ENOG4105DZ1 carboxypeptidase CFBP6624_10370 ENOG4108Z2U ureidoglycolate hydrolase CFBP6624_10405 ENOG4108TXN phosphonate metabolism protein CFBP6624_10410 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CFBP6624_10415 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CFBP6624_10420 ENOG4105BZU Histidine kinase CFBP6624_10425 ENOG4105C1J atp-dependent rna helicase CFBP6624_10435 ENOG4105MGM doxx family CFBP6624_10440 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CFBP6624_10480 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CFBP6624_10490 ENOG4108HWW ABC transporter CFBP6624_10500 ENOG4105DFW ABC transporter CFBP6624_10545 ENOG4105C6X Major Facilitator CFBP6624_10590 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family CFBP6624_10615 ENOG4108Z18 K06886 hemoglobin CFBP6624_10635 ENOG4108R86 Transcriptional regulator CFBP6624_10640 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CFBP6624_10650 ENOG4105WDY DNA (cytosine-5-)-methyltransferase CFBP6624_10655 ENOG4105CD3 dihydroorotase CFBP6624_10660 ENOG4105M6F mutator MutT protein CFBP6624_10675 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CFBP6624_10680 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CFBP6624_10705 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CFBP6624_10710 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CFBP6624_10715 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CFBP6624_10720 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CFBP6624_10735 ENOG4105CQM Urea amidohydrolase subunit alpha CFBP6624_10745 ENOG4105VTN Protein of unknown function (DUF1311) CFBP6624_10755 ENOG4105KI2 Urea amidohydrolase subunit beta CFBP6624_10760 ENOG4105XDF Protein of unknown function (DUF1272) CFBP6624_10765 ENOG4108YZ9 Urea amidohydrolase subunit gamma CFBP6624_10770 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CFBP6624_10780 ENOG4108IV0 ABC, transporter CFBP6624_10790 ENOG4105C0Z ABC transporter CFBP6624_10800 ENOG4105C32 Amino acid ABC transporter (Permease) CFBP6624_10820 ENOG4107R5B glutamine synthetase CFBP6624_10825 ENOG4105CHR reductase CFBP6624_10830 ENOG4105BZU Histidine kinase CFBP6624_10835 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CFBP6624_10845 ENOG4108ZJ4 polysaccharide deacetylase CFBP6624_10860 ENOG4108IV0 ABC, transporter CFBP6624_10865 ENOG4105C0Z ABC transporter CFBP6624_10870 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CFBP6624_10875 ENOG4105C32 Amino acid ABC transporter (Permease) CFBP6624_10880 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CFBP6624_10910 ENOG4105EFQ Two component transcriptional regulator (Winged helix family CFBP6624_10975 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CFBP6624_10985 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CFBP6624_11015 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CFBP6624_11025 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CFBP6624_11030 ENOG4107XDR Lactoylglutathione lyase CFBP6624_11035 ENOG4105WD1 Membrane CFBP6624_11040 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_11045 ENOG4105EHG Permease protein CFBP6624_11050 ENOG4107R4I Periplasmic binding protein CFBP6624_11060 ENOG41090JE Utilization Protein CFBP6624_11080 ENOG4105VUH addiction module killer protein CFBP6624_11090 ENOG41062D9 Histidine kinase CFBP6624_11130 ENOG4105DHS permease protein CFBP6624_11135 ENOG4105CM4 permease protein CFBP6624_11140 ENOG4108IPW abc transporter atp-binding protein CFBP6624_11145 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CFBP6624_11160 ENOG4105CV8 reductase CFBP6624_11165 ENOG4105F27 Major Facilitator CFBP6624_11170 ENOG4105EXG Transcriptional regulator CFBP6624_11175 ENOG4105CC0 LysR family Transcriptional regulator CFBP6624_11185 ENOG4105ENT Efflux transporter rnd family, mfp subunit CFBP6624_11205 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CFBP6624_11210 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) CFBP6624_11215 ENOG4107B2H carbonic anhydrase CFBP6624_11225 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CFBP6624_11240 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CFBP6624_11245 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CFBP6624_11250 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CFBP6624_11255 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CFBP6624_11260 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CFBP6624_11265 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) CFBP6624_11270 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) CFBP6624_11275 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) CFBP6624_11280 ENOG4108YNN Heme oxygenase CFBP6624_11285 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_11305 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_11315 ENOG4108MGF sugar kinase CFBP6624_11325 ENOG4105F0I Aminotransferase CFBP6624_11330 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CFBP6624_11340 ENOG4108JQ7 (ABC) transporter CFBP6624_11350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_11355 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_11360 ENOG4108J59 Extracellular solute-binding protein, family 5 CFBP6624_11365 ENOG4108IGT Dipeptidase CFBP6624_11395 ENOG4105D2S major facilitator superfamily CFBP6624_11415 ENOG4105KHM amidohydrolase 2 CFBP6624_11420 ENOG4108KC1 acyl-Coa dehydrogenase CFBP6624_11465 ENOG4105DHQ Histidine kinase CFBP6624_11470 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_11475 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CFBP6624_11480 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CFBP6624_11490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_11500 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CFBP6624_11505 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CFBP6624_11510 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CFBP6624_11515 ENOG4105D38 putrescine abc transporter CFBP6624_11520 ENOG4105F38 ABC transporter, permease CFBP6624_11525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_11570 ENOG4105CPW cytochrome b561 CFBP6624_11590 ENOG4105JQN Transcriptional regulator CFBP6624_11625 ENOG4105KVH Transcriptional regulator CFBP6624_11640 ENOG4105JQN Transcriptional regulator CFBP6624_11645 ENOG4105CHJ isochorismatase hydrolase CFBP6624_11655 ENOG4105JQN Transcriptional regulator CFBP6624_11665 ENOG4105CKD glutathione-regulated potassium-efflux system protein CFBP6624_11690 ENOG4108UQ8 endoribonuclease L-psp CFBP6624_11695 ENOG4105EUB pirin domain protein CFBP6624_11710 ENOG4105E1F short-chain dehydrogenase reductase CFBP6624_11760 ENOG4105C8V SAICAR synthetase CFBP6624_11770 ENOG4105C1P efflux transporter, rnd family, mfp subunit CFBP6624_11775 ENOG4105BZS acriflavin resistance protein CFBP6624_11785 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CFBP6624_11790 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CFBP6624_11810 ENOG4105CBN LysR family transcriptional regulator CFBP6624_11815 ENOG4105CJP fad dependent oxidoreductase CFBP6624_11820 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CFBP6624_11825 ENOG4105E0C molybdate abc transporter CFBP6624_11830 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_11840 ENOG4105KXX peptidase s58 dmpa CFBP6624_11845 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CFBP6624_11860 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CFBP6624_11865 ENOG410609C Acyl carrier protein CFBP6624_11895 ENOG4105BZ1 (ABC) transporter CFBP6624_11900 ENOG4105IJJ transcriptional regulator, crp fnr family CFBP6624_11920 ENOG4107QQG Dehydrogenase CFBP6624_11945 ENOG4107QSI ABC, transporter CFBP6624_11950 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_11955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_11965 ENOG4107TYR Glycosyl Transferase CFBP6624_11970 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CFBP6624_11975 ENOG4106N3A copper homeostasis protein cutc CFBP6624_11980 ENOG4105S8Q sugar efflux transporter CFBP6624_11990 ENOG4105E2D ec 3.2.1.52 CFBP6624_11995 ENOG4108KEZ Dehydrogenase CFBP6624_12000 ENOG4106KNT transcriptional regulator CFBP6624_12010 ENOG4108IJ9 (ABC) transporter CFBP6624_12020 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_12040 ENOG4105FDP GntR family transcriptional regulator CFBP6624_12050 ENOG4105CE4 GlcNAc 6-P deacetylase CFBP6624_12055 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) CFBP6624_12065 ENOG4105YVM Phosphoesterase, PA-phosphatase related CFBP6624_12070 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CFBP6624_12075 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CFBP6624_12085 ENOG4105CFU surface antigen CFBP6624_12095 ENOG4108V3W Chemotaxis protein, CheW CFBP6624_12100 ENOG4107SDU Methyl-accepting chemotaxis CFBP6624_12105 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CFBP6624_12110 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CFBP6624_12115 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CFBP6624_12120 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CFBP6624_12125 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CFBP6624_12130 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CFBP6624_12140 ENOG4105C25 Primosomal protein n' CFBP6624_12145 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CFBP6624_12165 ENOG4107QN2 dihydrolipoyl dehydrogenase CFBP6624_12170 ENOG4105N14 lysine exporter protein LysE YggA CFBP6624_12180 ENOG4105C7S Dehydrogenase CFBP6624_12190 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CFBP6624_12195 ENOG4105CMV Succinyl-CoA synthetase subunit beta CFBP6624_12200 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CFBP6624_12205 ENOG4105D6Z AFG1 family ATPase CFBP6624_12210 ENOG4105YU5 Outer membrane lipoprotein CFBP6624_12215 ENOG4105E33 succinate dehydrogenase CFBP6624_12225 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CFBP6624_12235 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) CFBP6624_12245 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CFBP6624_12260 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CFBP6624_12265 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CFBP6624_12270 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CFBP6624_12295 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CFBP6624_12305 ENOG410856B UPF0235 protein CFBP6624_12310 ENOG4105F0N pyrophosphate phospho-hydrolase CFBP6624_12330 ENOG4105DGW oligopeptidase A CFBP6624_12340 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CFBP6624_12350 ENOG4105CDH Citrulline--aspartate ligase CFBP6624_12355 ENOG4105DTD Dehydrogenase CFBP6624_12360 ENOG410829K Lysine exporter protein (Lyse ygga) CFBP6624_12365 ENOG4107T0D ABC, transporter CFBP6624_12370 ENOG4105C7J ABC transporter, permease CFBP6624_12380 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CFBP6624_12395 ENOG4105KZX Pterin carbinolamine dehydratase CFBP6624_12400 ENOG4105KJF protein tyrosine phosphatase CFBP6624_12405 ENOG4105M7V 2'-5' rna ligase CFBP6624_12415 ENOG4108I0Y (ABC) transporter CFBP6624_12425 ENOG4105HFZ Membrane CFBP6624_12440 ENOG4107QM5 aconitate hydratase CFBP6624_12445 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CFBP6624_12455 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) CFBP6624_12460 ENOG41060IM Heme exporter protein CFBP6624_12475 ENOG4106TD9 Diguanylate cyclase CFBP6624_12480 ENOG4108VRQ UPF0314 protein CFBP6624_12485 ENOG4107835 probably involved in intracellular septation (By similarity) CFBP6624_12490 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CFBP6624_12495 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CFBP6624_12500 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CFBP6624_12515 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CFBP6624_12520 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CFBP6624_12525 ENOG4105K5M 30s ribosomal protein S16 CFBP6624_12530 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CFBP6624_12535 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CFBP6624_12545 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CFBP6624_12555 ENOG4108HW4 amino acid AbC transporter CFBP6624_12570 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFBP6624_12575 ENOG4105ERG peptidase m48, ste24p CFBP6624_12585 ENOG4107T0D ABC, transporter CFBP6624_12605 ENOG4105C5H ABC transporter CFBP6624_12615 ENOG4105CVG Homoserine O-transsuccinylase CFBP6624_12620 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CFBP6624_12625 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase CFBP6624_12630 ENOG4105CTB Polyprenyl synthetase CFBP6624_12635 ENOG4108ZG0 Ompa motb domain protein CFBP6624_12640 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CFBP6624_12645 ENOG4106UW1 Major Facilitator superfamily CFBP6624_12650 ENOG4105MVE transcriptional regulator CFBP6624_12655 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CFBP6624_12660 ENOG4105WH1 Two component transcriptional regulator luxr family CFBP6624_12665 ENOG4105BZ1 (ABC) transporter CFBP6624_12675 ENOG4105E2V Glycosyltransferase 36 CFBP6624_12680 ENOG4105CH2 amidohydrolase CFBP6624_12690 ENOG4105D5U fad dependent oxidoreductase CFBP6624_12700 ENOG4105C01 Dihydroxy-acid dehydratase CFBP6624_12705 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CFBP6624_12710 ENOG4105EXW epimerase dehydratase CFBP6624_12715 ENOG4105CQB FAD linked oxidase domain protein CFBP6624_12720 ENOG4107YCY Transcriptional regulator CFBP6624_12730 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter CFBP6624_12735 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_12740 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CFBP6624_12745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CFBP6624_12755 ENOG4105DFA alanine racemase domain protein CFBP6624_12760 ENOG4105C8T Leucyl-tRNA synthetase CFBP6624_12775 ENOG4108Z4U Ferredoxin CFBP6624_12780 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CFBP6624_12800 ENOG4105C29 acyl-CoA thioesterase CFBP6624_12805 ENOG4108YZA Nitrogen regulatory protein pii CFBP6624_12810 ENOG4105BZU Histidine kinase CFBP6624_12815 ENOG4105CNU cell division protein FtsK CFBP6624_12820 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CFBP6624_12835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_12845 ENOG4108VJ1 Transcriptional regulator (CarD family CFBP6624_12850 ENOG4105C7I Dehydrogenase CFBP6624_12855 ENOG4105DEU major facilitator superfamily CFBP6624_12870 ENOG4105CHR reductase CFBP6624_12885 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CFBP6624_12895 ENOG4105CN1 protease CFBP6624_12905 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CFBP6624_12915 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CFBP6624_12920 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CFBP6624_12925 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CFBP6624_12930 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CFBP6624_12945 ENOG4105K46 50S ribosomal protein l27 CFBP6624_12950 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CFBP6624_12975 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CFBP6624_12980 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CFBP6624_12990 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CFBP6624_12995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CFBP6624_13000 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) CFBP6624_13065 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CFBP6624_13070 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CFBP6624_13075 ENOG4105EFT decarboxylase CFBP6624_13080 ENOG4105DIA mandelate racemase muconate lactonizing CFBP6624_13085 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CFBP6624_13095 ENOG4105CPQ Dehydrogenase CFBP6624_13115 ENOG4107RNG ABC transporter CFBP6624_13120 ENOG4105C2J ABC transporter CFBP6624_13125 ENOG4107YCY Transcriptional regulator CFBP6624_13130 ENOG4105CTX dehydratase CFBP6624_13135 ENOG4105DC1 bifunctional purine biosynthesis protein purh CFBP6624_13145 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CFBP6624_13150 ENOG4105D0M Protease HtpX homolog CFBP6624_13160 ENOG4105FA0 parb-like partition protein CFBP6624_13165 ENOG4107QJE Chromosome Partitioning Protein CFBP6624_13170 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) CFBP6624_13175 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CFBP6624_13180 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CFBP6624_13185 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CFBP6624_13190 ENOG4108YXA Membrane CFBP6624_13195 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CFBP6624_13205 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CFBP6624_13210 ENOG4108UHJ MAF-like protein CFBP6624_13215 ENOG4105E2X shikimate dehydrogenase CFBP6624_13220 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CFBP6624_13225 ENOG4108JDX DNA polymerase iii, epsilon subunit CFBP6624_13230 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) CFBP6624_13235 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 CFBP6624_13245 ENOG4105CA3 membrane-bound lytic murein transglycosylase CFBP6624_13260 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CFBP6624_13270 ENOG4105ERH Fumarylacetoacetate hydrolase CFBP6624_13285 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CFBP6624_13290 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CFBP6624_13295 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CFBP6624_13300 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CFBP6624_13305 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CFBP6624_13315 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CFBP6624_13325 ENOG4108S0S Nucleotidyl transferase CFBP6624_13330 ENOG4105EHM Aminoglycoside phosphotransferase CFBP6624_13335 ENOG4105I8F Histidine kinase CFBP6624_13345 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CFBP6624_13350 ENOG41080Z8 PHOSPHOCARRIER protein CFBP6624_13355 ENOG4108EQA pts system CFBP6624_13360 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CFBP6624_13365 ENOG4105EB3 Histidine kinase CFBP6624_13370 ENOG4105E3W Two component transcriptional regulator (Winged helix family CFBP6624_13375 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CFBP6624_13380 ENOG4108YZN class I peptide chain release factor CFBP6624_13385 ENOG4109066 lysm domain bon superfamily protein CFBP6624_13390 ENOG4105CS9 pantothenic acid kinase CFBP6624_13395 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase CFBP6624_13400 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CFBP6624_13405 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CFBP6624_13410 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CFBP6624_13420 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CFBP6624_13425 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CFBP6624_13430 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CFBP6624_13440 ENOG4107QP3 malate synthase g CFBP6624_13455 ENOG4108UYB regulatoR CFBP6624_13460 ENOG4105TX3 Histidine kinase CFBP6624_13465 ENOG4105CQ7 ATP-dependent helicase CFBP6624_13510 ENOG4105C9U ATP-dependent DNA helicase RecQ CFBP6624_13520 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator CFBP6624_13525 ENOG4105CNN ABC, transporter CFBP6624_13530 ENOG4105C2J ABC transporter CFBP6624_13535 ENOG4105CS9 pantothenic acid kinase CFBP6624_13540 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CFBP6624_13545 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CFBP6624_13555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CFBP6624_13565 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CFBP6624_13600 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CFBP6624_13605 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CFBP6624_13610 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CFBP6624_13615 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CFBP6624_13620 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CFBP6624_13625 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CFBP6624_13640 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CFBP6624_13645 ENOG4107SFI Major Facilitator superfamily CFBP6624_13650 ENOG4105CVE Lytic murein transglycosylase CFBP6624_13655 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CFBP6624_13665 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CFBP6624_13670 ENOG4107QMP dna polymerase iii subunits gamma and tau CFBP6624_13685 ENOG4105E09 nadh pyrophosphatase CFBP6624_13690 ENOG4105CQC Prephenate dehydratase CFBP6624_13695 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) CFBP6624_13700 ENOG4105G9V cytochrome C CFBP6624_13710 ENOG4108JQC penicillin-binding protein 1A CFBP6624_13715 ENOG4108UIN ybak prolyl-trna synthetase associated region CFBP6624_13735 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CFBP6624_13750 ENOG4105C2M dna polymerase I CFBP6624_13760 ENOG41082R8 50S ribosomal protein l32 CFBP6624_13765 ENOG4105CQZ Histidine kinase CFBP6624_13770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CFBP6624_13795 ENOG41069P5 Protein slyX homolog CFBP6624_13805 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CFBP6624_13810 ENOG4105CFG Acts as a chaperone (By similarity) CFBP6624_13865 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CFBP6624_13870 ENOG4105DIH basic membrane CFBP6624_13875 ENOG4108JQ9 ABC transporter CFBP6624_13890 ENOG4105KG3 cytidine deaminase CFBP6624_13895 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CFBP6624_13900 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CFBP6624_13905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CFBP6624_13915 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CFBP6624_13920 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CFBP6624_13925 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CFBP6624_13935 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CFBP6624_13940 ENOG4105CCU oxidase (Subunit III) CFBP6624_13945 ENOG4105BZ9 Cytochrome C oxidase, subunit I CFBP6624_13950 ENOG4105E2S oxidase) subunit II CFBP6624_13955 ENOG4105CSH Transporter CFBP6624_13960 ENOG4105CBC glutamate synthase CFBP6624_13965 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CFBP6624_13980 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CFBP6624_13990 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) CFBP6624_14005 ENOG4105EN6 Membrane CFBP6624_14025 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CFBP6624_14045 ENOG4108ZZF transport protein (ExbD) CFBP6624_14055 ENOG4105DG4 malate L-lactate dehydrogenase CFBP6624_14070 ENOG4105ECQ AraC Family Transcriptional Regulator CFBP6624_14075 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) CFBP6624_14080 ENOG4105FD8 phosphonate metabolism protein PhnM CFBP6624_14085 ENOG4108TXN phosphonate metabolism protein CFBP6624_14095 ENOG4105S7S phosphonate abc transporter CFBP6624_14100 ENOG4105EHI Phosphonate ABC transporter, periplasmic CFBP6624_14105 ENOG4105D5T phosphonate abc transporter CFBP6624_14115 ENOG4105HRV phosphonate c-p lyase system protein phnl CFBP6624_14120 ENOG4105ENV phosphonate C-P lyase system protein PhnK CFBP6624_14150 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CFBP6624_14155 ENOG4105CHC glucokinase (EC 2.7.1.2) CFBP6624_14160 ENOG4108Z5K methylglyoxal synthase CFBP6624_14165 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) CFBP6624_14175 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CFBP6624_14180 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CFBP6624_14185 ENOG4108JQ5 ABC transporter CFBP6624_14190 ENOG4105MWK D-amino acid dehydrogenase, small subunit CFBP6624_14195 ENOG4105CFQ glutamine synthetase CFBP6624_14200 ENOG4105CJP fad dependent oxidoreductase CFBP6624_14205 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CFBP6624_14210 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component CFBP6624_14215 ENOG4108IJ8 ABC transporter CFBP6624_14220 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component CFBP6624_14225 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CFBP6624_14235 ENOG4105KPV Transcriptional regulator CFBP6624_14250 ENOG4108M3P Membrane CFBP6624_14255 ENOG4105C26 Dehydrogenase CFBP6624_14270 ENOG4105DFI Membrane CFBP6624_14295 ENOG4107RH7 Nicotinate phosphoribosyltransferase CFBP6624_14300 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CFBP6624_14385 ENOG4105KWI UPF0339 protein CFBP6624_14390 ENOG4108UQ1 hydrolase, family 25 CFBP6624_14395 ENOG4105T38 integral membrane protein CFBP6624_14400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CFBP6624_14430 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CFBP6624_14465 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) CFBP6624_14470 ENOG4105CH5 extracellular solute-binding protein, family 7 CFBP6624_14495 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CFBP6624_14500 ENOG41082BR 50S ribosomal protein L35 CFBP6624_14505 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CFBP6624_14515 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CFBP6624_14520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CFBP6624_14525 ENOG4105CPC Aldo Keto reductase CFBP6624_14530 ENOG4105EQ2 LysR family Transcriptional regulator CFBP6624_14570 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CFBP6624_14575 ENOG4105CXK mandelate racemase muconate lactonizing CFBP6624_14585 ENOG4108ZT1 Transcriptional regulator CFBP6624_14590 ENOG4108KTG Membrane protein, drug metabolite transporter CFBP6624_14595 ENOG4105C88 aminopeptidase CFBP6624_14600 ENOG4108Z66 YbaK ebsC protein CFBP6624_14605 ENOG4105KUZ arsenate reductase CFBP6624_14625 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CFBP6624_14635 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CFBP6624_14650 ENOG4105KAV tspo and mbr like protein CFBP6624_14675 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CFBP6624_14680 ENOG4105K6T rare lipoprotein A CFBP6624_14690 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CFBP6624_14700 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CFBP6624_14725 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CFBP6624_14735 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CFBP6624_14740 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CFBP6624_14745 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CFBP6624_14750 ENOG41082FP UPF0102 protein CFBP6624_14775 ENOG4108IJ9 (ABC) transporter CFBP6624_14785 ENOG4105D7Z glutathione synthase CFBP6624_14790 ENOG4105C0P Mg chelatase subunit ChlI CFBP6624_14805 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CFBP6624_14810 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CFBP6624_14815 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CFBP6624_14830 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CFBP6624_14835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFBP6624_14840 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CFBP6624_14845 ENOG4105E39 Enoyl-CoA hydratase CFBP6624_14850 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CFBP6624_14890 ENOG4105NPE arsR family transcriptional regulator CFBP6624_14945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_14975 ENOG4107QIJ Aconitate hydratase 2 CFBP6624_15000 ENOG4108IJ6 ABC transporter CFBP6624_15010 ENOG4105ECY inositol monophosphatase CFBP6624_15015 ENOG4105CHR reductase CFBP6624_15020 ENOG4108FUF Transcriptional regulator, IclR family CFBP6624_15025 ENOG4105CMR udp-glucose 4-epimerase CFBP6624_15030 ENOG4108IJ9 (ABC) transporter CFBP6624_15035 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_15040 ENOG4105D56 permease protein CFBP6624_15055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_15060 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 CFBP6624_15065 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CFBP6624_15080 ENOG4105C7F AcnD-accessory protein PrpF CFBP6624_15085 ENOG4105F04 LysR family Transcriptional regulator CFBP6624_15100 ENOG4105C2W permease CFBP6624_15115 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_15175 ENOG4108JBU Outer membrane protein Omp31 CFBP6624_15190 ENOG4107SDU Methyl-accepting chemotaxis CFBP6624_15210 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CFBP6624_15215 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CFBP6624_15220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_15225 ENOG4105DRS transport system, permease CFBP6624_15260 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_15270 ENOG4105C5I Dehydrogenase CFBP6624_15275 ENOG4108WBH protein TIM barrel CFBP6624_15280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_15285 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CFBP6624_15290 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CFBP6624_15295 ENOG4105BZ7 extracellular solute-binding protein family 1 CFBP6624_15300 ENOG4108W9H Tetr family transcriptional regulator CFBP6624_15320 ENOG4105DDC Oxidoreductase domain protein CFBP6624_15325 ENOG4105VEQ Cold shock protein CFBP6624_15335 ENOG4105K5G 30S ribosomal protein S21 CFBP6624_15355 ENOG4105FAT Acyl-transferase CFBP6624_15360 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CFBP6624_15375 ENOG4105X58 receptor CFBP6624_15380 ENOG4107XII Glycosyl Hydrolase Family 88 CFBP6624_15385 ENOG4105GAK amidohydrolase 2 CFBP6624_15390 ENOG4105CXK mandelate racemase muconate lactonizing CFBP6624_15395 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CFBP6624_15400 ENOG4105CHR reductase CFBP6624_15405 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CFBP6624_15410 ENOG4105E9Z Nad-dependent epimerase dehydratase CFBP6624_15415 ENOG4105JXH GntR family transcriptional regulator CFBP6624_15460 ENOG41063TF transcriptional regulator (AraC CFBP6624_15465 ENOG4105EU0 Major facilitator Superfamily CFBP6624_15475 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_15485 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CFBP6624_15490 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CFBP6624_15505 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_15510 ENOG4105CPQ Dehydrogenase CFBP6624_15515 ENOG4105CHR reductase CFBP6624_15525 ENOG4107UEK pfkb domain protein CFBP6624_15530 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of CFBP6624_15545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_15555 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_15560 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CFBP6624_15570 ENOG4105C28 cystathionine CFBP6624_15580 ENOG4105DSE periplasmic solute binding protein CFBP6624_15585 ENOG4105CC5 ABC transporter CFBP6624_15590 ENOG4105DIK (ABC) transporter CFBP6624_15595 ENOG4105CKI cobalamin synthesis protein CFBP6624_15610 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CFBP6624_15615 ENOG4105C0B DNA polymerase III (alpha subunit) CFBP6624_15620 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA CFBP6624_15645 ENOG4105BZU Histidine kinase CFBP6624_15650 ENOG4105D01 (LipO)protein CFBP6624_15655 ENOG4108UMI ABC transporter, permease CFBP6624_15660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_15665 ENOG4108RCM Nitroreductase CFBP6624_15705 ENOG4105CC0 LysR family Transcriptional regulator CFBP6624_15710 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_15715 ENOG4105CNN ABC, transporter CFBP6624_15730 ENOG4105BZS acriflavin resistance protein CFBP6624_15735 ENOG4105C1P efflux transporter, rnd family, mfp subunit CFBP6624_15740 ENOG4105BZU Histidine kinase CFBP6624_15745 ENOG4105S0E allantoin catabolism protein CFBP6624_15760 ENOG4105DG4 malate L-lactate dehydrogenase CFBP6624_15770 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_15780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_15785 ENOG4108JQ6 ABC transporter CFBP6624_15795 ENOG4107STF Involved in phosphonate degradation (By similarity) CFBP6624_15810 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CFBP6624_15820 ENOG4105C01 Dihydroxy-acid dehydratase CFBP6624_15825 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CFBP6624_15830 ENOG4105C2J ABC transporter CFBP6624_15835 ENOG4107R9N ABC transporter CFBP6624_15840 ENOG41062B0 ABC transporter, permease CFBP6624_15845 ENOG4107EJG GntR family transcriptional regulator CFBP6624_15860 ENOG4105CKI cobalamin synthesis protein CFBP6624_15865 ENOG4108IJG ABC transporter substrate-binding protein CFBP6624_15870 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CFBP6624_15875 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CFBP6624_15880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_15895 ENOG4105C93 Xylose Isomerase CFBP6624_15905 ENOG4105CMG Carbohydrate kinase CFBP6624_15925 ENOG4105J7D transcriptional regulator CFBP6624_15930 ENOG4105EE5 Membrane protein terC CFBP6624_15940 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CFBP6624_15950 ENOG4105CRK lysyL-tRNA synthetase CFBP6624_15960 ENOG4105DSE periplasmic solute binding protein CFBP6624_15965 ENOG4105DIK (ABC) transporter CFBP6624_15970 ENOG4105CC5 ABC transporter CFBP6624_15975 ENOG4105CC5 ABC transporter CFBP6624_15985 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr CFBP6624_15990 ENOG4107258 Transcriptional regulator CFBP6624_15995 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CFBP6624_16000 ENOG4105DKT Transcriptional regulator CFBP6624_16015 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CFBP6624_16020 ENOG4107YCY Transcriptional regulator CFBP6624_16025 ENOG4108ERU trap dicarboxylate transporter subunit DctP CFBP6624_16035 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_16040 ENOG4105CPQ Dehydrogenase CFBP6624_16045 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CFBP6624_16065 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CFBP6624_16070 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_16075 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CFBP6624_16085 ENOG41080HT Transcriptional regulator, arsr family CFBP6624_16090 ENOG4105CYM Glutathione S-transferase CFBP6624_16095 ENOG4108JQ6 ABC transporter CFBP6624_16100 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) CFBP6624_16115 ENOG41069H0 dihydroorotase EC 3.5.2.3 CFBP6624_16130 ENOG4106R87 Extracellular solute-binding protein, family 5 CFBP6624_16170 ENOG4107QM2 Aldo Keto reductase CFBP6624_16185 ENOG4108IJ9 (ABC) transporter CFBP6624_16190 ENOG4107T3P ABC, transporter CFBP6624_16195 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CFBP6624_16200 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_16205 ENOG4105CJQ hydrolase, family 31 CFBP6624_16270 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component CFBP6624_16275 ENOG4107Z6I Thiamine biosynthesis protein CFBP6624_16280 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CFBP6624_16285 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CFBP6624_16305 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CFBP6624_16310 ENOG4105MWK D-amino acid dehydrogenase, small subunit CFBP6624_16330 ENOG4105CK2 sodium dicarboxylate symporter CFBP6624_16345 ENOG4106PGW Short-chain dehydrogenase reductase Sdr CFBP6624_16355 ENOG4105CH2 amidohydrolase CFBP6624_16375 ENOG4107QZ7 Cellulose synthase catalytic subunit CFBP6624_16385 ENOG4107SZR mannose-6-phosphate isomerase CFBP6624_16410 ENOG4105C1B dTDP-glucose 4-6-dehydratase CFBP6624_16420 ENOG41086KC Transcriptional regulator CFBP6624_16435 ENOG4108JJ6 Type I secretion system ATPase CFBP6624_16440 ENOG4107QZV Type I secretion membrane fusion protein CFBP6624_16470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFBP6624_16480 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_16490 ENOG4105CHR reductase CFBP6624_16500 ENOG4108VX5 3-methyladenine DNA glycosylase CFBP6624_16515 ENOG4105FKQ transcriptional regulator CFBP6624_16520 ENOG4107T3P ABC, transporter CFBP6624_16535 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_16545 ENOG4107RJ5 oxidoreductase CFBP6624_16550 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CFBP6624_16555 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CFBP6624_16560 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CFBP6624_16565 ENOG4105D9R oxidoreductase CFBP6624_16580 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CFBP6624_16585 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CFBP6624_16605 ENOG4105C6K Malic enzyme CFBP6624_16620 ENOG4105DRP amino acid AbC transporter CFBP6624_16625 ENOG4105CDA abc transporter atp-binding protein CFBP6624_16630 ENOG4108PGP mmge prpd family protein CFBP6624_16635 ENOG4105CPU Monooxygenase CFBP6624_16640 ENOG4107SDU Methyl-accepting chemotaxis CFBP6624_16645 ENOG4105MWK D-amino acid dehydrogenase, small subunit CFBP6624_16665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_16670 ENOG4105CH5 extracellular solute-binding protein, family 7 CFBP6624_16675 ENOG4108Z86 Glutamine amidotransferase CFBP6624_16680 ENOG4105CNN ABC, transporter CFBP6624_16685 ENOG4105C2J ABC transporter CFBP6624_16700 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B CFBP6624_16730 ENOG4106P55 Transcriptional regulator CFBP6624_16735 ENOG4105D44 asparaginase CFBP6624_16750 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_16770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_16775 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_16780 ENOG4108S01 response regulator CFBP6624_16785 ENOG4105JSC dimethylmenaquinone methyltransferase CFBP6624_16790 ENOG4105E9Z Nad-dependent epimerase dehydratase CFBP6624_16805 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CFBP6624_16810 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CFBP6624_16820 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CFBP6624_16825 ENOG4105D9R oxidoreductase CFBP6624_16870 ENOG4108KPJ rna polymerase sigma factor CFBP6624_16875 ENOG4105E0A ABC, transporter CFBP6624_16880 ENOG4105EHG Permease protein CFBP6624_16895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFBP6624_16905 ENOG4105E0A ABC, transporter CFBP6624_16910 ENOG4105EHG Permease protein CFBP6624_16925 ENOG4105CWC Acetylornithine deacetylase CFBP6624_16930 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CFBP6624_16940 ENOG4105C26 Dehydrogenase CFBP6624_16945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CFBP6624_16950 ENOG4105C26 Dehydrogenase CFBP6624_16955 ENOG4105CJP fad dependent oxidoreductase CFBP6624_16970 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFBP6624_16990 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_16995 ENOG4108JQ6 ABC transporter CFBP6624_17000 ENOG4108RYR transcriptional regulator AsnC family CFBP6624_17005 ENOG4108DN8 FAD dependent oxidoreductase CFBP6624_17015 ENOG4105EAB amino acid AbC transporter CFBP6624_17020 ENOG4105CDA abc transporter atp-binding protein CFBP6624_17030 ENOG4105CH2 amidohydrolase CFBP6624_17040 ENOG4105DEN Luciferase family CFBP6624_17045 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family CFBP6624_17055 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CFBP6624_17070 ENOG4105KHC sulfurtransferase CFBP6624_17085 ENOG4105C1G acyl-Coa dehydrogenase CFBP6624_17120 ENOG4105CPC Aldo Keto reductase CFBP6624_17130 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_17135 ENOG4105CPU Monooxygenase CFBP6624_17150 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_17155 ENOG4105CH2 amidohydrolase CFBP6624_17160 ENOG4105FBW Monooxygenase CFBP6624_17180 ENOG4108M8W Monooxygenase CFBP6624_17185 ENOG4105DIA mandelate racemase muconate lactonizing CFBP6624_17195 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_17200 ENOG4108JQ7 (ABC) transporter CFBP6624_17205 ENOG4105C3U ABC transporter CFBP6624_17215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_17230 ENOG4105JXH GntR family transcriptional regulator CFBP6624_17235 ENOG4107S76 domain protein CFBP6624_17240 ENOG41080HT Transcriptional regulator, arsr family CFBP6624_17250 ENOG4105KFG YeeE YedE family protein CFBP6624_17255 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CFBP6624_17265 ENOG4107QSN dihydrolipoamide acetyltransferase CFBP6624_17270 ENOG4105CPP Dehydrogenase, E1 component CFBP6624_17275 ENOG4107R0V Pyruvate dehydrogenase CFBP6624_17280 ENOG4105C1G acyl-Coa dehydrogenase CFBP6624_17285 ENOG4105CHU acetyl-coa acetyltransferase CFBP6624_17290 ENOG4105J0Q Transcriptional regulator CFBP6624_17295 ENOG4105C1G acyl-Coa dehydrogenase CFBP6624_17300 ENOG4107QX3 carboxylase CFBP6624_17310 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CFBP6624_17315 ENOG4108IPT Naphthoate synthase CFBP6624_17320 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CFBP6624_17325 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CFBP6624_17330 ENOG4105C9F isomerase CFBP6624_17340 ENOG4105E98 transcriptional regulator DeoR family CFBP6624_17355 ENOG4105C2J ABC transporter CFBP6624_17360 ENOG4105CNN ABC, transporter CFBP6624_17365 ENOG4105CNN ABC, transporter CFBP6624_17370 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CFBP6624_17385 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CFBP6624_17410 ENOG4105F1N DNA alkylation repair CFBP6624_17415 ENOG4108IJ6 ABC transporter CFBP6624_17420 ENOG4105ECW sulfate abc transporter CFBP6624_17425 ENOG4108I5D sulfate abc transporter CFBP6624_17430 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein CFBP6624_17435 ENOG4105E39 Enoyl-CoA hydratase CFBP6624_17450 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CFBP6624_17470 ENOG4105VW4 glutaredoxin 3 CFBP6624_17475 ENOG41081UC Inherit from COG: Competence protein CFBP6624_17480 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CFBP6624_17495 ENOG4105M6F mutator MutT protein CFBP6624_17505 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CFBP6624_17510 ENOG4105EIN peptidylprolyl cis-trans isomerase CFBP6624_17515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CFBP6624_17565 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CFBP6624_17765 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFBP6624_17845 ENOG4107QRS glycosyltransferase group 2 family protein CFBP6624_17855 ENOG4105CPK Glycosyl transferase (Group 1 CFBP6624_17885 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CFBP6624_17905 ENOG4108IJ9 (ABC) transporter CFBP6624_17910 ENOG4105EG2 ABC transporter, permease CFBP6624_17965 ENOG4108WRK Transcriptional regulator CFBP6624_17975 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CFBP6624_17980 ENOG4105C2J ABC transporter CFBP6624_17985 ENOG4107RNG ABC transporter CFBP6624_17990 ENOG4105DFW ABC transporter CFBP6624_18005 ENOG41082BM Transcriptional regulator, arsr family CFBP6624_18010 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CFBP6624_18035 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) CFBP6624_18045 ENOG4105CYM Glutathione S-transferase CFBP6624_18050 ENOG4107QX3 carboxylase CFBP6624_18055 ENOG4105CFF transcriptional regulator CFBP6624_18065 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CFBP6624_18075 ENOG4105E1F short-chain dehydrogenase reductase CFBP6624_18085 ENOG4108WBT adenosyltransferase CFBP6624_18095 ENOG4105BZJ Electron transfer flavoprotein CFBP6624_18100 ENOG4105C10 Electron transfer flavoprotein CFBP6624_18105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CFBP6624_18110 ENOG4107ZT5 Thiol disulfide interchange protein CFBP6624_18115 ENOG4105CH7 arginosuccinase CFBP6624_18125 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CFBP6624_18140 ENOG4108UGV hypoxanthine phosphoribosyltransferase CFBP6624_18150 ENOG4105CAK Cell division ATP-binding protein ftsE CFBP6624_18170 ENOG4108NH8 Cation transport protein CFBP6624_18190 ENOG4105CIH Imidazole acetol-phosphate transaminase CFBP6624_18195 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CFBP6624_18200 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CFBP6624_18215 ENOG4105KDC 50s ribosomal protein l28 CFBP6624_18220 ENOG4105EX9 Membrane CFBP6624_18255 ENOG4105D49 3-dehydroquinate synthase CFBP6624_18260 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CFBP6624_18275 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CFBP6624_18280 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CFBP6624_18285 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CFBP6624_18290 ENOG4105VFE sira family CFBP6624_18300 ENOG4105CKI cobalamin synthesis protein CFBP6624_18305 ENOG4105DZ1 carboxypeptidase CFBP6624_18315 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 CFBP6624_18320 ENOG4105D2N Aldolase CFBP6624_18325 ENOG4105CNN ABC, transporter CFBP6624_18335 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_18340 ENOG41061GT Aldolase CFBP6624_18345 ENOG4105DRR Transcriptional regulator, GntR family CFBP6624_18365 ENOG4105CPQ Dehydrogenase CFBP6624_18370 ENOG4105CMG Carbohydrate kinase CFBP6624_18380 ENOG4105CMT Dihydroxyacetone kinase CFBP6624_18385 ENOG4105JQN Transcriptional regulator CFBP6624_18390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CFBP6624_18415 ENOG4105ENX hydrolase CFBP6624_18425 ENOG4105EQ2 LysR family Transcriptional regulator CFBP6624_18435 ENOG4107SET aldo keto reductase CFBP6624_18450 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFBP6624_18460 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CFBP6624_18470 ENOG4105C26 Dehydrogenase CFBP6624_18480 ENOG4105CNV Aldolase CFBP6624_18485 ENOG4108JQ1 Dehydrogenase CFBP6624_18505 ENOG4107SDZ Galactoside transport system permease protein mglC CFBP6624_18520 ENOG4108JQB penicillin-binding protein 1C CFBP6624_18525 ENOG4105DN3 alpha-2-macroglobulin domain protein CFBP6624_18530 ENOG4105W49 UPF0434 protein CFBP6624_18540 ENOG4105K63 Thioredoxin CFBP6624_18560 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CFBP6624_18575 ENOG4108JQ1 Dehydrogenase CFBP6624_18590 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CFBP6624_18595 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CFBP6624_18600 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CFBP6624_18610 ENOG4105KCK Peptidoglycan-associated lipoprotein CFBP6624_18615 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CFBP6624_18625 ENOG4105SG9 biopolymer transport protein, ExbD CFBP6624_18630 ENOG4105E02 MotA TolQ exbB proton channel CFBP6624_18635 ENOG4107YD3 Thioesterase CFBP6624_18645 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CFBP6624_18655 ENOG4105DIN metallophosphoesterase CFBP6624_18660 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CFBP6624_18665 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CFBP6624_18670 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CFBP6624_18680 ENOG4105DEN Luciferase family CFBP6624_18685 ENOG4105CDY transcriptional regulatory protein CFBP6624_18700 ENOG4105D48 metallophosphoesterase CFBP6624_18755 ENOG4105BZA Phosphoglycerate kinase CFBP6624_18760 ENOG4107R1Y fructose-bisphosphate aldolase CFBP6624_18780 ENOG41082FS 50S ribosomal protein L31 CFBP6624_18785 ENOG4105BZ1 (ABC) transporter CFBP6624_18795 ENOG4105UYK outer membrane protein a CFBP6624_18805 ENOG4105ECY inositol monophosphatase CFBP6624_18835 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CFBP6624_18840 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CFBP6624_18845 ENOG4105YK5 50S ribosomal protein L36 CFBP6624_18850 ENOG4105M0T TPR Repeat-Containing Protein CFBP6624_18855 ENOG4105Y2X UPF0335 protein CFBP6624_18875 ENOG4105CA9 Pyruvate kinase CFBP6624_18880 ENOG4105EAQ (twin-arginine translocation) pathway signal CFBP6624_18885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CFBP6624_18890 ENOG4105DPN Oligoendopeptidase f CFBP6624_18895 ENOG4107Z5F Aminotransferase class IV CFBP6624_18905 ENOG4105FE5 Homospermidine synthase CFBP6624_18910 ENOG4105ZWB Outer membrane lipoprotein CFBP6624_18915 ENOG4105CGH 5'-nucleotidase CFBP6624_18920 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CFBP6624_18925 ENOG4107QX8 SPFH domain, Band 7 family protein CFBP6624_18935 ENOG4105C2X Arabinose 5-phosphate isomerase CFBP6624_18960 ENOG4105CVE Lytic murein transglycosylase CFBP6624_18975 ENOG4106F60 Histidine kinase CFBP6624_18990 ENOG4105C5W Aldolase CFBP6624_19000 ENOG4105C08 Histidine kinase CFBP6624_19005 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CFBP6624_19010 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CFBP6624_19015 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CFBP6624_19025 ENOG4105HDK L-asparaginase CFBP6624_19035 ENOG4108IJ0 Aspartate ammonia-lyase CFBP6624_19040 ENOG41073TP transcriptional regulator CFBP6624_19045 ENOG4105BZS acriflavin resistance protein CFBP6624_19055 ENOG4105C1P efflux transporter, rnd family, mfp subunit CFBP6624_19060 ENOG4105PF9 Transcriptional regulator CFBP6624_19065 ENOG4105C26 Dehydrogenase CFBP6624_19070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_19075 ENOG4105D38 putrescine abc transporter CFBP6624_19080 ENOG4105F38 ABC transporter, permease CFBP6624_19095 ENOG4105C26 Dehydrogenase CFBP6624_19100 ENOG4108M8W Monooxygenase CFBP6624_19110 ENOG4108MXF Alpha Beta Hydrolase CFBP6624_19125 ENOG4105CDA abc transporter atp-binding protein CFBP6624_19130 ENOG4105E5Q amino acid AbC transporter CFBP6624_19150 ENOG4105C5F glutamine synthetase CFBP6624_19155 ENOG4105CBC glutamate synthase CFBP6624_19160 ENOG4105M90 Glutamate synthase alpha subunit domain protein CFBP6624_19165 ENOG4105EYU Glutamine amido-transferase CFBP6624_19175 ENOG4105ECQ AraC Family Transcriptional Regulator CFBP6624_19180 ENOG4105DDR sarcosine oxidase (Beta subunit) CFBP6624_19185 ENOG4105WIU sarcosine oxidase delta subunit CFBP6624_19190 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CFBP6624_19200 ENOG4105CQ4 Transcriptional regulator CFBP6624_19210 ENOG4105CNN ABC, transporter CFBP6624_19215 ENOG4105C2J ABC transporter CFBP6624_19220 ENOG4105F0H myo-inositol catabolism protein CFBP6624_19225 ENOG4105CIB oxidoreductase Domain protein CFBP6624_19230 ENOG4107QP6 Xylose isomerase domain protein TIM barrel CFBP6624_19235 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CFBP6624_19240 ENOG4105DWY Agmatine deiminase CFBP6624_19255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_19265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_19275 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_19290 ENOG4105C0A alcohol dehydrogenase CFBP6624_19295 ENOG41073TP transcriptional regulator CFBP6624_19310 ENOG4105NAU thioesterase Superfamily protein CFBP6624_19335 ENOG4105NPQ Pfam:DUF403 CFBP6624_19350 ENOG4105C5H ABC transporter CFBP6624_19355 ENOG4105C5I Dehydrogenase CFBP6624_19400 ENOG4105E5Q amino acid AbC transporter CFBP6624_19405 ENOG4105E5Q amino acid AbC transporter CFBP6624_19415 ENOG4105CPQ Dehydrogenase CFBP6624_19420 ENOG4105JSC dimethylmenaquinone methyltransferase CFBP6624_19425 ENOG4107R0W ABC transporter CFBP6624_19435 ENOG4105DRP amino acid AbC transporter CFBP6624_19440 ENOG4105DRP amino acid AbC transporter CFBP6624_19450 ENOG4105C5I Dehydrogenase CFBP6624_19455 ENOG4105DTD Dehydrogenase CFBP6624_19460 ENOG4105EXW epimerase dehydratase CFBP6624_19475 ENOG4105JSC dimethylmenaquinone methyltransferase CFBP6624_19480 ENOG4105JN3 extra-cytoplasmic solute receptor family protein CFBP6624_19495 ENOG4105DFI Membrane CFBP6624_19500 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CFBP6624_19505 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CFBP6624_19515 ENOG4105P4J Allophanate hydrolase, subunit 1 CFBP6624_19520 ENOG4107R7A Allophanate hydrolase subunit 2 CFBP6624_19525 ENOG4105E7W lamb ycsf family protein CFBP6624_19530 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_19540 ENOG4108I5D sulfate abc transporter CFBP6624_19545 ENOG4105F38 ABC transporter, permease CFBP6624_19550 ENOG4105CHM Aminotransferase CFBP6624_19565 ENOG4105CMG Carbohydrate kinase CFBP6624_19570 ENOG41061GT Aldolase CFBP6624_19580 ENOG4108FN7 Aldo keto reductase CFBP6624_19590 ENOG4105CNN ABC, transporter CFBP6624_19595 ENOG4105C2J ABC transporter CFBP6624_19630 ENOG4108ZNX Heat shock protein CFBP6624_19635 ENOG4105DHU Bile acid CFBP6624_19645 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CFBP6624_19660 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CFBP6624_19675 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_19680 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CFBP6624_19685 ENOG4105E98 transcriptional regulator DeoR family CFBP6624_19690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CFBP6624_19710 ENOG4108IFG nitrite reductase, (NAD(P)H) CFBP6624_19715 ENOG4105D7T ABC transporter CFBP6624_19740 ENOG4105DRR Transcriptional regulator, GntR family CFBP6624_19745 ENOG4105C5A transporter CFBP6624_19750 ENOG4105E7W lamb ycsf family protein CFBP6624_19755 ENOG4105CFM UPF0317 protein CFBP6624_19760 ENOG4107R7A Allophanate hydrolase subunit 2 CFBP6624_19765 ENOG4108JIK carboxylase CFBP6624_19770 ENOG4105E5K Alpha-amylase CFBP6624_19775 ENOG4108Z4X TRANSCRIPTIONal CFBP6624_19780 ENOG4105D05 Receptor CFBP6624_19785 ENOG4108I0Q anthranilate phosphoribosyltransferase CFBP6624_19825 ENOG4105KME endoribonuclease L-psp CFBP6624_19840 ENOG41090B9 response to stress CFBP6624_19845 ENOG4105CGP Urocanate hydratase CFBP6624_19855 ENOG4105C84 Histidine ammonia-lyase CFBP6624_19860 ENOG4105CI2 imidazolone-5-propionate hydrolase CFBP6624_19865 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CFBP6624_19915 ENOG4108YIQ Alpha beta hydrolase CFBP6624_19945 ENOG4105C0A alcohol dehydrogenase CFBP6624_19980 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CFBP6624_19990 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CFBP6624_20000 ENOG4108NUI synthase CFBP6624_20025 ENOG4105BZS acriflavin resistance protein CFBP6624_20030 ENOG4108JQ5 ABC transporter CFBP6624_20035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_20040 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_20045 ENOG4108J59 Extracellular solute-binding protein, family 5 CFBP6624_20050 ENOG4105I1K ABC transporter CFBP6624_20075 ENOG4105BZU Histidine kinase CFBP6624_20095 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CFBP6624_20110 ENOG4105EFZ amidohydrolase CFBP6624_20120 ENOG4107SFI Major Facilitator superfamily CFBP6624_20130 ENOG4105C1P efflux transporter, rnd family, mfp subunit CFBP6624_20135 ENOG4105BZS acriflavin resistance protein CFBP6624_20170 ENOG4107QM5 aconitate hydratase CFBP6624_20175 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) CFBP6624_20185 ENOG4105EWV Sodium calcium exchanger membrane region CFBP6624_20190 ENOG4107S78 Band 7 protein CFBP6624_20210 ENOG4105EQ2 LysR family Transcriptional regulator CFBP6624_20215 ENOG4105C57 major facilitator superfamily CFBP6624_20255 ENOG4105EB3 Histidine kinase CFBP6624_20260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_20265 ENOG4108QIF Phosphoesterase, PA-phosphatase related CFBP6624_20280 ENOG4105K5X acetyltransferase CFBP6624_20285 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CFBP6624_20295 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CFBP6624_20300 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CFBP6624_20305 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CFBP6624_20330 ENOG4108JHT EamA-like transporter family CFBP6624_20345 ENOG4105F8J Adenylate Guanylate cyclase CFBP6624_20360 ENOG4105CSH Transporter CFBP6624_20365 ENOG4105ECM Sensor protein basS pmrB CFBP6624_20370 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_20375 ENOG4105DIJ Phosphoethanolamine transferase CFBP6624_20390 ENOG4105S6R Iron-hydroxamate transporter permease subunit CFBP6624_20395 ENOG4105E0A ABC, transporter CFBP6624_20405 ENOG4105G9V cytochrome C CFBP6624_20430 ENOG4105C2J ABC transporter CFBP6624_20435 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_20445 ENOG4105BZU Histidine kinase CFBP6624_20450 ENOG4105WH1 Two component transcriptional regulator luxr family CFBP6624_20470 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) CFBP6624_20475 ENOG4105D3G Pseudouridine synthase CFBP6624_20490 ENOG4108IJ7 Glycine betaine CFBP6624_20495 ENOG4108HQS Glycine betaine CFBP6624_20505 ENOG4105CQZ Histidine kinase CFBP6624_20510 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CFBP6624_20590 ENOG4105K5G 30S ribosomal protein S21 CFBP6624_20595 ENOG4105DDR sarcosine oxidase (Beta subunit) CFBP6624_20610 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CFBP6624_20630 ENOG4108ESZ Glycogen debranching enzyme CFBP6624_20635 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CFBP6624_20640 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CFBP6624_20645 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CFBP6624_20650 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CFBP6624_20655 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CFBP6624_20685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CFBP6624_20690 ENOG4105CHR reductase CFBP6624_20695 ENOG4105CPQ Dehydrogenase CFBP6624_20705 ENOG4108JJ9 ABC, transporter CFBP6624_20710 ENOG4108JJ8 (ABC) transporter CFBP6624_20715 ENOG4105C4M (Ubiquinol oxidase) subunit I CFBP6624_20720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CFBP6624_20745 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CFBP6624_20750 ENOG4108IYU L-aspartate oxidase CFBP6624_20755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CFBP6624_20820 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CFBP6624_20850 ENOG4105CAT Cytidine monophosphate kinase CFBP6624_20855 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CFBP6624_20895 ENOG4105DC7 peptidase M24 CFBP6624_20900 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_20905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_20910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_20915 ENOG4105C3U ABC transporter CFBP6624_20920 ENOG4108JQ7 (ABC) transporter CFBP6624_20925 ENOG4105DEI Mannitol dehydrogenase CFBP6624_20935 ENOG4105DIA mandelate racemase muconate lactonizing CFBP6624_20955 ENOG4105C0Z ABC transporter CFBP6624_20960 ENOG4108IV0 ABC, transporter CFBP6624_20965 ENOG4105C32 Amino acid ABC transporter (Permease) CFBP6624_20970 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CFBP6624_20985 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CFBP6624_21000 ENOG4105DZG Dehydrogenase CFBP6624_21005 ENOG4108Z9Z response to DNA damage stimulus CFBP6624_21010 ENOG4108302 MgtC SapB transporter CFBP6624_21035 ENOG4108Z0Z intracellular protease Pfpi family CFBP6624_21060 ENOG4105D7Z glutathione synthase CFBP6624_21065 ENOG4105C1B dTDP-glucose 4-6-dehydratase CFBP6624_21070 ENOG4105C6Y Udp-glucose 6-dehydrogenase CFBP6624_21080 ENOG4105CHF Glutathione S-transferase CFBP6624_21085 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_21090 ENOG4105C26 Dehydrogenase CFBP6624_21100 ENOG4105EW9 transcriptional regulator AsnC family CFBP6624_21115 ENOG41074H6 response regulator CFBP6624_21150 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) CFBP6624_21160 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CFBP6624_21180 ENOG4105CFH Aspartokinase CFBP6624_21185 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CFBP6624_21190 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CFBP6624_21195 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CFBP6624_21205 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CFBP6624_21210 ENOG4105E4C Lytic transglycosylase catalytic CFBP6624_21260 ENOG4105C2J ABC transporter CFBP6624_21265 ENOG4105CNN ABC, transporter CFBP6624_21270 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_21275 ENOG4107QP6 Xylose isomerase domain protein TIM barrel CFBP6624_21285 ENOG4105F0H myo-inositol catabolism protein CFBP6624_21290 ENOG4105D9R oxidoreductase CFBP6624_21310 ENOG4105CDA abc transporter atp-binding protein CFBP6624_21315 ENOG4105DRP amino acid AbC transporter CFBP6624_21320 ENOG4105E5Q amino acid AbC transporter CFBP6624_21325 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_21335 ENOG4105C26 Dehydrogenase CFBP6624_21340 ENOG4105CTU Proline racemase CFBP6624_21350 ENOG4105CHR reductase CFBP6624_21365 ENOG4105CS6 Rhs element vgr protein CFBP6624_21450 ENOG4105CH5 extracellular solute-binding protein, family 7 CFBP6624_21455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CFBP6624_21485 ENOG4105CGP Urocanate hydratase CFBP6624_21495 ENOG4105C84 Histidine ammonia-lyase CFBP6624_21515 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CFBP6624_21520 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_21525 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_21530 ENOG4108JQ7 (ABC) transporter CFBP6624_21555 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_21560 ENOG4105US7 Histidine kinase CFBP6624_21565 ENOG4105DJY efflux transporter, rnd family, mfp subunit CFBP6624_21580 ENOG4105KVH Transcriptional regulator CFBP6624_21585 ENOG4105EJC lysr family transcriptional regulator CFBP6624_21590 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CFBP6624_21615 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CFBP6624_21635 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CFBP6624_21640 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CFBP6624_21655 ENOG4107P2S Transcriptional regulator CFBP6624_21660 ENOG4105F7P transcriptional regulator AsnC family CFBP6624_21665 ENOG4105C28 cystathionine CFBP6624_21670 ENOG4108SNK aliphatic sulfonates import ATP-binding protein SsuB CFBP6624_21675 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CFBP6624_21680 ENOG4105GVF (ABC) transporter CFBP6624_21690 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CFBP6624_21735 ENOG4108ZT1 Transcriptional regulator CFBP6624_21740 ENOG4105CQ0 ABC transporter CFBP6624_21765 ENOG4105BZW Glycerate kinase CFBP6624_21800 ENOG4105CBN LysR family transcriptional regulator CFBP6624_21805 ENOG4105EQX glucarate dehydratase CFBP6624_21815 ENOG4105C5I Dehydrogenase CFBP6624_21825 ENOG4105CHR reductase CFBP6624_21835 ENOG4105E0S extracellular solute-binding protein family 1 CFBP6624_21840 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CFBP6624_21850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_21855 ENOG4107XBN GntR Family Transcriptional Regulator CFBP6624_21865 ENOG4108IG5 Transcriptional regulator CFBP6624_21880 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CFBP6624_21895 ENOG4105CPQ Dehydrogenase CFBP6624_21905 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_21915 ENOG4105CNN ABC, transporter CFBP6624_21925 ENOG4105EF1 ribulokinase CFBP6624_21960 ENOG4106VK6 Flagellar motor protein CFBP6624_22015 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CFBP6624_22035 ENOG4105BZU Histidine kinase CFBP6624_22055 ENOG4105EAM Na Pi-cotransporter CFBP6624_22060 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_22065 ENOG4107RCV ABC transporter, permease CFBP6624_22070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_22090 ENOG4105ECY inositol monophosphatase CFBP6624_22100 ENOG4105EE5 Membrane protein terC CFBP6624_22125 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_22130 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component CFBP6624_22135 ENOG4105BZ7 extracellular solute-binding protein family 1 CFBP6624_22140 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CFBP6624_22150 ENOG4105FKQ transcriptional regulator CFBP6624_22165 ENOG4105CBN LysR family transcriptional regulator CFBP6624_22185 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_22190 ENOG4107QP6 Xylose isomerase domain protein TIM barrel CFBP6624_22205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_22210 ENOG4105D38 putrescine abc transporter CFBP6624_22235 ENOG4105E7U AraC family transcriptional regulator CFBP6624_22240 ENOG4105DDR sarcosine oxidase (Beta subunit) CFBP6624_22250 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CFBP6624_22265 ENOG4105D8X mechanosensitive ion channel CFBP6624_22285 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CFBP6624_22290 ENOG4105C2J ABC transporter CFBP6624_22295 ENOG4105CNN ABC, transporter CFBP6624_22300 ENOG4105CNN ABC, transporter CFBP6624_22305 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_22375 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CFBP6624_22415 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CFBP6624_22420 ENOG4105K78 MarR family Transcriptional regulator CFBP6624_22430 ENOG4105CFP Peptidase U32 CFBP6624_22455 ENOG4108IY8 ABC, transporter CFBP6624_22480 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CFBP6624_22505 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CFBP6624_22510 ENOG4105WQI isochorismatase CFBP6624_22515 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CFBP6624_22520 ENOG4105E4F Isochorismate synthase CFBP6624_22530 ENOG4105C0W non-ribosomal peptide synthetase CFBP6624_22535 ENOG4105CEY Amp-dependent synthetase and ligase CFBP6624_22545 ENOG4105Q26 Siderophore-interacting protein CFBP6624_22555 ENOG4105EHG Permease protein CFBP6624_22560 ENOG4105DQ5 transport system permease protein CFBP6624_22565 ENOG4105E0A ABC, transporter CFBP6624_22570 ENOG4105CPU Monooxygenase CFBP6624_22580 ENOG4107RBR Receptor CFBP6624_22585 ENOG4105C1G acyl-Coa dehydrogenase CFBP6624_22590 ENOG4105ETT transcriptional Regulator, LysR family CFBP6624_22595 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_22605 ENOG4105F38 ABC transporter, permease CFBP6624_22615 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_22625 ENOG4105CPN adenine deaminase CFBP6624_22630 ENOG4107RSM transcriptional regulator CFBP6624_22635 ENOG4105D94 Major Facilitator Superfamily CFBP6624_22640 ENOG4105CH2 amidohydrolase CFBP6624_22650 ENOG4108IGT Dipeptidase CFBP6624_22655 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_22660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_22665 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_22670 ENOG4105C3U ABC transporter CFBP6624_22675 ENOG4108JQ7 (ABC) transporter CFBP6624_22680 ENOG4108M0I Transcriptional regulator CFBP6624_22685 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_22695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_22700 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CFBP6624_22705 ENOG4107R7Y intracellular protease Pfpi family CFBP6624_22715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_22725 ENOG4107QSI ABC, transporter CFBP6624_22730 ENOG4105CH2 amidohydrolase CFBP6624_22735 ENOG4108JQ6 ABC transporter CFBP6624_22740 ENOG4105DKT Transcriptional regulator CFBP6624_22760 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_22765 ENOG4105CHR reductase CFBP6624_22770 ENOG4105DEI Mannitol dehydrogenase CFBP6624_22775 ENOG4107YBY Hydrolase CFBP6624_22780 ENOG4105EF1 ribulokinase CFBP6624_22805 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CFBP6624_22810 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CFBP6624_22815 ENOG4107QMS site-determining protein CFBP6624_22820 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) CFBP6624_22830 ENOG4107RP9 extracellular solute-binding protein, family 3 CFBP6624_22855 ENOG4105EPC oxidoreductase CFBP6624_22865 ENOG4105XN3 extracellular solute-binding protein family 1 CFBP6624_22870 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CFBP6624_22875 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CFBP6624_22895 ENOG4105C72 UPF0176 protein CFBP6624_22905 ENOG41080ZE Adenylate cyclase CFBP6624_22910 ENOG4108UHU Aldolase CFBP6624_22935 ENOG4105D7X high-affinity nickel-transporter CFBP6624_22975 ENOG4105CKI cobalamin synthesis protein CFBP6624_22985 ENOG4107MII Sugar-specific transcriptional regulator TrmB CFBP6624_22990 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_23000 ENOG4105C5I Dehydrogenase CFBP6624_23015 ENOG4105DH8 myo-inositol catabolism CFBP6624_23025 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CFBP6624_23030 ENOG4105EDK PfkB domain protein CFBP6624_23040 ENOG4108IV0 ABC, transporter CFBP6624_23045 ENOG4105C0Z ABC transporter CFBP6624_23060 ENOG4105CAD extracellular ligand-binding receptor CFBP6624_23080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_23090 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CFBP6624_23095 ENOG4108JQ6 ABC transporter CFBP6624_23120 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CFBP6624_23125 ENOG4107S9B Shikimate dehydrogenase CFBP6624_23130 ENOG4105CDA abc transporter atp-binding protein CFBP6624_23135 ENOG4105CT1 (ABC) transporter CFBP6624_23140 ENOG4105E5Q amino acid AbC transporter CFBP6624_23145 ENOG4105E5Q amino acid AbC transporter CFBP6624_23150 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CFBP6624_23155 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CFBP6624_23160 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta CFBP6624_23165 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CFBP6624_23175 ENOG4105DDW LysR family Transcriptional regulator CFBP6624_23180 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase CFBP6624_23190 ENOG4107HP6 Transcriptional regulator CFBP6624_23200 ENOG4107QNJ CoA-transferase subunit B CFBP6624_23205 ENOG4105CHU acetyl-coa acetyltransferase CFBP6624_23210 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_23225 ENOG4105F0H myo-inositol catabolism protein CFBP6624_23230 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CFBP6624_23240 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_23245 ENOG4105DRS transport system, permease CFBP6624_23255 ENOG4108IJ9 (ABC) transporter CFBP6624_23265 ENOG4105F5H Glycosyl Hydrolase Family 88 CFBP6624_23295 ENOG4108IJ9 (ABC) transporter CFBP6624_23300 ENOG4105E0C molybdate abc transporter CFBP6624_23310 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CFBP6624_23325 ENOG4108Z4U Ferredoxin CFBP6624_23330 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CFBP6624_23345 ENOG4105C09 Bile acid CFBP6624_23350 ENOG4105CPC Aldo Keto reductase CFBP6624_23385 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CFBP6624_23390 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CFBP6624_23425 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CFBP6624_23440 ENOG4108KQJ Type 11 methyltransferase CFBP6624_23445 ENOG4105CMR udp-glucose 4-epimerase CFBP6624_23480 ENOG4105C4R Atp-dependent dna helicase CFBP6624_23490 ENOG4108JQ7 (ABC) transporter CFBP6624_23500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_23505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_23510 ENOG4107YCY Transcriptional regulator CFBP6624_23515 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CFBP6624_23530 ENOG4105BZU Histidine kinase CFBP6624_23545 ENOG4105FDF Could be involved in DNA repair (By similarity) CFBP6624_23550 ENOG4105DQE DNA ligase CFBP6624_23555 ENOG4105FDF Could be involved in DNA repair (By similarity) CFBP6624_23560 ENOG4107QXV Phosphate transporter CFBP6624_23565 ENOG4107GRR phosphate transport regulator CFBP6624_23585 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_23590 ENOG4105GR3 Histidine kinase CFBP6624_23640 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) CFBP6624_23655 ENOG4105E0K tonB-dependent siderophore receptor CFBP6624_23665 ENOG4105DQ5 transport system permease protein CFBP6624_23670 ENOG4108IHU transport system permease protein CFBP6624_23675 ENOG4105E0A ABC, transporter CFBP6624_23680 ENOG4105CC0 LysR family Transcriptional regulator CFBP6624_23690 ENOG4107XVH Transcriptional regulator CFBP6624_23700 ENOG4105C32 Amino acid ABC transporter (Permease) CFBP6624_23710 ENOG4105C0Z ABC transporter CFBP6624_23715 ENOG4108IV0 ABC, transporter CFBP6624_23725 ENOG4105DND Transcriptional regulator CFBP6624_23735 ENOG4105CBG Sulfatase CFBP6624_23740 ENOG4108RVA ribokinase CFBP6624_23750 ENOG4106IQC argininosuccinate lyase CFBP6624_23755 ENOG4105DRS transport system, permease CFBP6624_23765 ENOG4107FKK extracellular solute-binding protein family 1 CFBP6624_23770 ENOG4105DKQ ROK family CFBP6624_23810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_23815 ENOG4108JQ5 ABC transporter CFBP6624_23820 ENOG4105F8D glycoside hydrolase family 4 CFBP6624_23825 ENOG4105D0S secretion protein (HlyD CFBP6624_23830 ENOG4105CJ1 ABC, transporter CFBP6624_23835 ENOG4105CMI transporter CFBP6624_23850 ENOG41074H6 response regulator CFBP6624_23855 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CFBP6624_23865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CFBP6624_23870 ENOG4105DG4 malate L-lactate dehydrogenase CFBP6624_23880 ENOG4105E5Q amino acid AbC transporter CFBP6624_23885 ENOG4105E5Q amino acid AbC transporter CFBP6624_23905 ENOG4105CTU Proline racemase CFBP6624_23910 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_23920 ENOG4105E89 ABC transporter CFBP6624_23925 ENOG4105E5Q amino acid AbC transporter CFBP6624_23930 ENOG4105E5Q amino acid AbC transporter CFBP6624_23940 ENOG4105C5I Dehydrogenase CFBP6624_23945 ENOG4105BZU Histidine kinase CFBP6624_23955 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CFBP6624_23965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_23970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_23980 ENOG4105CPN adenine deaminase CFBP6624_23985 ENOG4105C3U ABC transporter CFBP6624_23990 ENOG4108JQ7 (ABC) transporter CFBP6624_23995 ENOG4105DRR Transcriptional regulator, GntR family CFBP6624_24000 ENOG4107XWI flavin reductase domain protein, FMN-binding CFBP6624_24005 ENOG410633P Hydantoin racemase CFBP6624_24020 ENOG41067RQ csbd family CFBP6624_24025 ENOG4105WH1 Two component transcriptional regulator luxr family CFBP6624_24040 ENOG4107QIZ NADH dehydrogenase CFBP6624_24045 ENOG4108JB9 formate dehydrogenase CFBP6624_24055 ENOG4105FCD Major Facilitator CFBP6624_24070 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CFBP6624_24090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CFBP6624_24095 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_24100 ENOG4108JQ6 ABC transporter CFBP6624_24105 ENOG4105CXK mandelate racemase muconate lactonizing CFBP6624_24115 ENOG4108QBF Transcriptional regulator CFBP6624_24120 ENOG4105DEF Extracellular solute-binding protein, family 5 CFBP6624_24130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CFBP6624_24135 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CFBP6624_24140 ENOG4108JQ6 ABC transporter CFBP6624_24155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CFBP6624_24160 ENOG4105C4Y ABC transporter CFBP6624_24165 ENOG4105C4Y ABC transporter CFBP6624_24170 ENOG4107RCV ABC transporter, permease CFBP6624_24175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CFBP6624_24190 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CFBP6624_24200 ENOG4108JJ7 ABC transporter CFBP6624_24225 ENOG4105C2J ABC transporter CFBP6624_24230 ENOG4105CNN ABC, transporter CFBP6624_24240 ENOG4107TTA Xylose isomerase domain protein TIM barrel CFBP6624_24250 ENOG4107TTA Xylose isomerase domain protein TIM barrel CFBP6624_24270 ENOG4105EMU Dehydrogenase CFBP6624_24275 ENOG410642W LysR family Transcriptional regulator CFBP6624_24300 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase CFBP6624_24305 ENOG4105ENR peptidase, M24 CFBP6624_24320 ENOG4107SQD Transcriptional regulator, GntR family CFBP6624_24330 ENOG4105C26 Dehydrogenase CFBP6624_24345 ENOG4105BZU Histidine kinase CFBP6624_24355 ENOG4105HEE Binding Domain protein CFBP6624_24370 ENOG4105CIG ABC transporter CFBP6624_24375 ENOG4108T0W nitrous oxide maturation protein NosY CFBP6624_24395 ENOG4105EQK -acetyltransferase CFBP6624_24495 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CFBP6624_24500 ENOG4105CCU oxidase (Subunit III) CFBP6624_24505 ENOG4105BZ9 Cytochrome C oxidase, subunit I CFBP6624_24510 ENOG4105E2S oxidase) subunit II CFBP6624_24515 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CFBP6624_24525 ENOG4105W1Y Transcriptional regulator CFBP6624_24530 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CFBP6624_24540 ENOG4105C59 p-type ATPase CFBP6624_24550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CFBP6624_24555 ENOG4105DIJ Phosphoethanolamine transferase CFBP6624_24560 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CFBP6624_24570 ENOG4108R9S DSBA oxidoreductase CFBP6624_24575 ENOG4105PGM cation diffusion facilitator family transporter CFBP6624_24625 ENOG4107ZT5 Thiol disulfide interchange protein CFBP6624_24635 ENOG4105E3B Multicopper oxidase CFBP6624_24645 ENOG4108IJF Heavy metal efflux pump, CzcA CFBP6624_24675 ENOG4105BZU Histidine kinase CFBP6624_24700 ENOG4107QPB Beta-lactamase domain protein CFBP6624_24710 ENOG4108XM1 transcriptional regulator AsnC family CFBP6624_24740 ENOG4108VSE mercuric transport protein CFBP6624_24750 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CFBP6624_24805 ENOG4108VYJ response regulator receiver protein CFBP6624_24815 ENOG4107W75 Flagellin CFBP6624_24820 ENOG4107W75 Flagellin CFBP6624_24880 ENOG4108C33 Resolvase CFBP6624_24920 ENOG4108VSE mercuric transport protein CFBP6624_24930 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CFBP6624_25015 ENOG4107R16 Multicopper oxidase CFBP6624_25035 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CFBP6624_25040 ENOG4105CY0 Metallo-Beta-Lactamase CFBP6624_25075 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CFBP6624_25090 ENOG4108M0I Transcriptional regulator CFBP6624_25125 ENOG4105VPX protein, conserved in bacteria CFBP6624_25140 ENOG4108IJF Heavy metal efflux pump, CzcA CFBP6624_25165 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CFBP6624_25200 ENOG4108EHY type IV secretion system CFBP6624_25205 ENOG4105E5H Transposase CFBP6624_25210 ENOG4108YXQ IS66 Orf2 family protein CFBP6624_25215 ENOG41061A5 transposase CFBP6624_25235 ENOG4105C4R Atp-dependent dna helicase CFBP6624_25250 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CFBP6624_25455 ENOG4108V42 Type IV secretion system protein VirB8 CFBP6624_25465 ENOG4105CMA conjugation trbi family protein CFBP6624_25470 ENOG4108EHY type IV secretion system CFBP6624_25560 ENOG4105X54 addiction module antidote protein CFBP6624_25580 ENOG4105K70 DNA-binding protein CFBP6624_25600 ENOG4105E80 TraG TraD family protein CFBP6624_25650 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CFBP6624_25655 ENOG4105C10 Electron transfer flavoprotein CFBP6624_25660 ENOG4105BZJ Electron transfer flavoprotein CFBP6624_25665 ENOG4105C26 Dehydrogenase CFBP6624_25675 ENOG4105C32 Amino acid ABC transporter (Permease) CFBP6624_25685 ENOG4108IV0 ABC, transporter CFBP6624_25690 ENOG4105C0Z ABC transporter CFBP6624_25700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CFBP6624_25705 ENOG4105CEY Amp-dependent synthetase and ligase CFBP6624_25715 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CFBP6624_25720 ENOG4105C0A alcohol dehydrogenase CFBP6624_25735 ENOG4108C33 Resolvase CFBP6624_25745 ENOG4105C0A alcohol dehydrogenase CFBP6624_25750 ENOG4105C26 Dehydrogenase CFBP6624_25755 ENOG4107258 Transcriptional regulator CFBP6624_25780 ENOG4105C4W S-formylglutathione hydrolase CFBP6624_25800 ENOG4108WUH Transcriptional regulator, TetR family CFBP6624_25805 ENOG410903D sensor protein CFBP6624_25815 ENOG4108IND Tetr family transcriptional regulator CFBP6624_25855 ENOG4107RKG DJ-1/PfpI family CFBP6624_25860 ENOG4105E2A Dehydrogenase CFBP6624_25875 ENOG4105EMU Dehydrogenase CFBP6624_25880 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound CFBP6624_25900 ENOG4105C5Q Transcriptional regulator CFBP6624_25925 ENOG4105BZU Histidine kinase CFBP6624_25950 ENOG4105ETE Transcriptional regulator (LacI family CFBP6624_25960 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CFBP6624_25965 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CFBP6624_25970 ENOG4105CE4 GlcNAc 6-P deacetylase CFBP6624_25990 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CFBP6624_26000 ENOG4105DEI Mannitol dehydrogenase CFBP6624_26030 ENOG4105BZU Histidine kinase CFBP6624_26045 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CFBP6624_26055 ENOG4107RP9 extracellular solute-binding protein, family 3 CFBP6624_26060 ENOG4105EAD ABC transporter CFBP6624_26065 ENOG4105E5Q amino acid AbC transporter CFBP6624_26070 ENOG4105EQI Metal Dependent Phosphohydrolase CFBP6624_26110 ENOG4105DQE DNA ligase CFBP6624_26135 ENOG4108C33 Resolvase CFBP6624_26150 ENOG4108IJF Heavy metal efflux pump, CzcA CFBP6624_26175 ENOG4105DXI Major Facilitator superfamily CFBP6624_26260 ENOG4105F8J Adenylate Guanylate cyclase CFBP6624_26270 ENOG4105DQR SNARE associated Golgi CFBP6624_26280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_26330 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_26345 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_26365 ENOG410841Q phosphoesterase PA-phosphatase related protein CFBP6624_26370 ENOG4107R16 Multicopper oxidase CFBP6624_26385 ENOG4105DIJ Phosphoethanolamine transferase CFBP6624_26395 ENOG4105F8J Adenylate Guanylate cyclase CFBP6624_26450 ENOG4107R4J Chloride channel CFBP6624_26455 ENOG4105WMR Protein CrcB homolog CFBP6624_26470 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CFBP6624_26480 ENOG4108A65 Transcriptional regulator CFBP6624_26485 ENOG4105CAU Arsenical resistance protein, ArsH CFBP6624_26495 ENOG4105H3G oxidoreductase CFBP6624_26500 ENOG4105D6J arsenicaL-resistance protein CFBP6624_26510 ENOG4107WAU Protein tyrosine phosphatase CFBP6624_26525 ENOG4105S7S phosphonate abc transporter CFBP6624_26530 ENOG4105D5T phosphonate abc transporter CFBP6624_26545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_26550 ENOG4108UTW Plays a role in the regulation of phosphate uptake CFBP6624_26560 ENOG4105E2Z phosphate ABC transporter (Permease CFBP6624_26565 ENOG4105C8U phosphate abc transporter CFBP6624_26570 ENOG4105PWN phosphate abc transporter CFBP6624_26575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CFBP6624_26585 ENOG4105BZU Histidine kinase CFBP6624_26590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CFBP6624_26610 ENOG4105CVM Molybdenum cofactor synthesis domain protein CFBP6624_26670 ENOG4105XJC Two component transcriptional regulator (Winged helix family CFBP6624_26675 ENOG4105DHQ Histidine kinase CFBP6624_26690 ENOG4107S76 domain protein CFBP6624_26695 ENOG41080HT Transcriptional regulator, arsr family CFBP6624_26710 ENOG4108VCT Sulfite exporter TauE/SafE CFBP6624_26715 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase CFBP6624_26720 ENOG4108ZNX Heat shock protein CFBP6624_26730 ENOG4107R16 Multicopper oxidase CFBP6624_26750 ENOG4105CEI nitrite reductase CFBP6624_26785 ENOG4105F7V ErfK ybiS ycfS ynhG family protein CFBP6624_26795 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CFBP6624_26800 ENOG4107QIV Cytochrome c biogenesis protein CFBP6624_26805 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CFBP6624_26825 ENOG4105W1Y Transcriptional regulator CFBP6624_26835 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)