locus-tag class description EML4_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EML4_00010 ENOG4105CSA Coproporphyrinogen iii oxidase EML4_00015 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EML4_00020 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EML4_00025 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EML4_00030 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EML4_00035 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EML4_00040 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea EML4_00045 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EML4_00050 ENOG4108IUZ ABC transporter EML4_00055 ENOG4105RF0 OstA family EML4_00065 ENOG4105D07 Signal peptide peptidase, SppA EML4_00070 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EML4_00080 ENOG4105DR4 Methyltransferase EML4_00085 ENOG4108RWN rrna methyltransferase EML4_00090 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EML4_00095 ENOG4105BZU Histidine kinase EML4_00105 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EML4_00110 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EML4_00115 ENOG4105CJR Integral membrane protein (MviN EML4_00125 ENOG4105C31 Tryptophanyl-tRNA synthetase EML4_00135 ENOG41083MR nifu domain-containing protein EML4_00140 ENOG41072GX Peptidase M22 Glycoprotease EML4_00150 ENOG41090R7 Ferric uptake EML4_00155 ENOG4108Z20 Acyl-transferase EML4_00160 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EML4_00165 ENOG4105C9A Phoh family EML4_00170 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EML4_00180 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EML4_00185 ENOG4108WRK Transcriptional regulator EML4_00190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EML4_00195 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EML4_00200 ENOG4108RVA ribokinase EML4_00205 ENOG4105CGY Dna recombination protein EML4_00210 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EML4_00215 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EML4_00220 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EML4_00230 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EML4_00235 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EML4_00250 ENOG4105DU0 nucleoside hydrolase EML4_00255 ENOG4108ZNX Heat shock protein EML4_00280 ENOG4105CAS nag kinase EML4_00290 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EML4_00295 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EML4_00300 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EML4_00325 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EML4_00330 ENOG4108IJ9 (ABC) transporter EML4_00335 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EML4_00340 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EML4_00355 ENOG4105CYC Transferase EML4_00365 ENOG4105CTU Proline racemase EML4_00370 ENOG4105EKE dihydroorotase EML4_00375 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EML4_00395 ENOG4105DBV ornithine carbamoyltransferase EML4_00400 ENOG4107QP8 phosphohexose isomerase EML4_00405 ENOG4105CEY Amp-dependent synthetase and ligase EML4_00410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_00415 ENOG4107QKW extracellular solute-binding protein family 1 EML4_00420 ENOG4107Z6A sulfate abc transporter permease EML4_00425 ENOG4105E0K tonB-dependent siderophore receptor EML4_00465 ENOG4105D9P serine threonine protein kinase EML4_00520 ENOG4105CSR polyphosphate kinase 2 EML4_00525 ENOG4105BZU Histidine kinase EML4_00530 ENOG4105PWN phosphate abc transporter EML4_00535 ENOG4105C8U phosphate abc transporter EML4_00545 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EML4_00550 ENOG4108UTW Plays a role in the regulation of phosphate uptake EML4_00555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EML4_00565 ENOG4105C8Y Acetylornithine aminotransferase EML4_00570 ENOG4105DBV ornithine carbamoyltransferase EML4_00580 ENOG4105NWN ApaG protein EML4_00590 ENOG4105DHP deoxycytidine triphosphate deaminase EML4_00600 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) EML4_00605 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EML4_00655 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EML4_00670 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EML4_00690 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EML4_00695 ENOG4107QRT dEAD DEAH box helicase EML4_00725 ENOG4105CSU acyl-Coa dehydrogenase EML4_00730 ENOG4105CHU acetyl-coa acetyltransferase EML4_00735 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EML4_00760 ENOG4105KJM monovalent cation h antiporter subunit g EML4_00765 ENOG4105W4C monovalent cation H antiporter subunit F EML4_00770 ENOG4105SC1 monovalent cation H antiporter subunit E EML4_00775 ENOG4107R4Z monovalent cation h antiporter subunit d EML4_00780 ENOG4108ZE9 Monovalent cation H antiporter subunit C EML4_00785 ENOG4105D65 subunit l EML4_00795 ENOG4105UT3 Methyl-accepting chemotaxis EML4_00810 ENOG4105CBS Chea signal transduction histidine kinase EML4_00815 ENOG4105BZU Histidine kinase EML4_00820 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EML4_00825 ENOG4108VYJ response regulator receiver protein EML4_00830 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EML4_00840 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EML4_00845 ENOG4105VJY transcriptional regulator EML4_00860 ENOG4105BZU Histidine kinase EML4_00865 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EML4_00870 ENOG4105CHM Aminotransferase EML4_00885 ENOG41086Q3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EML4_00890 ENOG4108Z03 MAF-like protein EML4_00895 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EML4_00905 ENOG4108ZTZ UPF0262 protein EML4_00910 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EML4_00920 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EML4_00940 ENOG4107W75 Flagellin EML4_00950 ENOG4105CN7 Flagellar biosynthetic protein FliP EML4_00960 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EML4_00970 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EML4_00975 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA EML4_00980 ENOG4105CGA flagellar basal-body rod protein FlgG EML4_00985 ENOG4105X50 flagellar hook-basal body complex protein fliE EML4_00990 ENOG4108ZC9 flagellar basal-body rod protein flgc EML4_00995 ENOG4105SFI flagellar basal-body rod protein EML4_01005 ENOG4108JIR Flagellum-specific ATP synthase EML4_01010 ENOG4105KTQ flagellar basal-body rod protein EML4_01020 ENOG4107RD7 Flagellar Motor Protein, MotA EML4_01030 ENOG4105DD5 Flagellar motor switch protein EML4_01035 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EML4_01040 ENOG4105D00 flagellar biosynthetic protein flhB EML4_01045 ENOG4105QDQ EML4_01060 ENOG4105ER2 Ompa motb domain protein EML4_01065 ENOG4108S15 chemotaxis, protein EML4_01105 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) EML4_01110 ENOG410822I Flagellar hook capping protein EML4_01115 ENOG4105VS8 Flagellar biosynthetic protein fliq EML4_01120 ENOG4105D7B Flagellar biosynthesis protein flha EML4_01125 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EML4_01160 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EML4_01165 ENOG4105FKQ transcriptional regulator EML4_01170 ENOG4105EPJ extracellular solute-binding protein family 1 EML4_01175 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component EML4_01180 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EML4_01185 ENOG4105CG3 alpha amylase, catalytic region EML4_01190 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_01205 ENOG4105C01 Dihydroxy-acid dehydratase EML4_01210 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) EML4_01215 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EML4_01220 ENOG4105CJP fad dependent oxidoreductase EML4_01230 ENOG4105CBX hi0933 family EML4_01265 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_01270 ENOG4105F38 ABC transporter, permease EML4_01275 ENOG4105D38 putrescine abc transporter EML4_01285 ENOG4105BZU Histidine kinase EML4_01295 ENOG4105C9X ppx gppa phosphatase EML4_01300 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) EML4_01305 ENOG4105C0R drug resistance transporter emrb qaca subfamily EML4_01335 ENOG4108RIR Molybdenum cofactor biosynthesis protein EML4_01340 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EML4_01350 ENOG4105EAH synthase EML4_01375 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EML4_01385 ENOG4108V0P LemA family EML4_01390 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EML4_01400 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EML4_01405 ENOG4105EWC Purine nucleoside phosphorylase EML4_01410 ENOG4105C8Q Methyl-accepting chemotaxis EML4_01420 ENOG4105C12 Phosphoribosylglycinamide synthetase EML4_01425 ENOG4105BZM domain protein EML4_01430 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EML4_01475 ENOG4105CJ3 phosphate transporter EML4_01485 ENOG4108E2B had-superfamily hydrolase, subfamily iib EML4_01490 ENOG4107STW synthase EML4_01495 ENOG4105C6F GntR Family Transcriptional Regulator EML4_01505 ENOG410642W LysR family Transcriptional regulator EML4_01510 ENOG4105CQB FAD linked oxidase domain protein EML4_01520 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EML4_01530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_01535 ENOG4108R3E Dna-3-methyladenine glycosylase i EML4_01545 ENOG4105HMI Membrane EML4_01550 ENOG4108M0I Transcriptional regulator EML4_01580 ENOG4105CUT histidyl-tRNA synthetase EML4_01590 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit EML4_01595 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EML4_01600 ENOG4108SB3 DoxX Family EML4_01610 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EML4_01615 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EML4_01625 ENOG4105DTN riboflavin biosynthesis protein ribF EML4_01630 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EML4_01640 ENOG4108Z6B deaminase EML4_01645 ENOG4105FE9 pseudouridine synthase EML4_01650 ENOG4106H78 methyltransferase EML4_01655 ENOG4105D78 K07001 NTE family protein EML4_01665 ENOG4105CMS peptidase U62, modulator of DNA gyrase EML4_01670 ENOG4107TK4 histidinol-phosphate phosphatase EML4_01680 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EML4_01690 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EML4_01705 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EML4_01710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EML4_01715 ENOG4105BZU Histidine kinase EML4_01720 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EML4_01725 ENOG4108RTU Aldolase EML4_01730 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EML4_01735 ENOG4105FGE Short-chain dehydrogenase reductase Sdr EML4_01740 ENOG4107HP6 Transcriptional regulator EML4_01745 ENOG4107WYG Transcriptional regulator, luxr family EML4_01755 ENOG4105D1F ATP-binding protein EML4_01760 ENOG4107QUT magnesium and cobalt transport protein CorA EML4_01765 ENOG4105DFH Transport of potassium into the cell (By similarity) EML4_01780 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) EML4_01785 ENOG4105VD1 ATP synthase subunit C EML4_01790 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EML4_01810 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EML4_01830 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EML4_01840 ENOG4105DVW rieske (2Fe-2S) EML4_01850 ENOG4105W6J BA14K family EML4_01855 ENOG4105W6J BA14K family EML4_01865 ENOG4105CSU acyl-Coa dehydrogenase EML4_01880 ENOG4107QS4 23S rRNA EML4_01885 ENOG4105DX0 Hemolysin A EML4_01890 ENOG4105C8Q Methyl-accepting chemotaxis EML4_01900 ENOG4105FKN transcriptional regulator, AsnC family EML4_01925 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EML4_01930 ENOG4105EUB pirin domain protein EML4_01935 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EML4_01945 ENOG4107ZYJ bioY protein EML4_01950 ENOG4107QCX Transporter EML4_01955 ENOG4108JJB ABC transporter EML4_01960 ENOG4105T0Z Conserved Protein EML4_01970 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EML4_01990 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EML4_02005 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EML4_02025 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 EML4_02035 ENOG4105D1U peptidase U62 modulator of DNA gyrase EML4_02045 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EML4_02050 ENOG4105BZ9 Cytochrome C oxidase, subunit I EML4_02055 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EML4_02060 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) EML4_02065 ENOG4107QS1 Cytochrome C Oxidase, Subunit III EML4_02075 ENOG4108R6F Surfeit locus 1 family protein EML4_02080 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EML4_02085 ENOG4105CUV Homoserine Kinase EML4_02090 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EML4_02100 ENOG4105EHV domain protein EML4_02110 ENOG4108UJU UPF0301 protein EML4_02115 ENOG4108J08 Csbd family EML4_02125 ENOG4105BZU Histidine kinase EML4_02130 ENOG4105D9U N-acetyltransferase EML4_02140 ENOG4105D98 threonine synthase EML4_02160 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 EML4_02165 ENOG4108PVQ transcriptional regulator EML4_02180 ENOG4105CEC DNA methylase N-4 N-6 EML4_02185 ENOG4105YAJ CopG Arc MetJ EML4_02190 ENOG4105KRP Plasmid stabilization system EML4_02200 ENOG4105CEN a g-specific adenine glycosylase EML4_02215 ENOG4108R9S DSBA oxidoreductase EML4_02220 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EML4_02225 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EML4_02230 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EML4_02245 ENOG4108ETY sodium dicarboxylate symporter EML4_02275 ENOG4105DWT malate dehydrogenase (quinone) EML4_02290 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EML4_02295 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EML4_02300 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EML4_02305 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family EML4_02310 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EML4_02315 ENOG4108I5D sulfate abc transporter EML4_02325 ENOG4108IJ6 ABC transporter EML4_02335 ENOG4108NJZ Sensory box GGDEF EAL domain protein EML4_02345 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EML4_02350 ENOG4105C26 Dehydrogenase EML4_02355 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EML4_02390 ENOG4107MKT Stringent starvation protein a EML4_02400 ENOG4105C0R drug resistance transporter emrb qaca subfamily EML4_02410 ENOG4107T0X DNA ligase EML4_02420 ENOG4108ST3 glycosyltransferase EML4_02430 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_02435 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_02440 ENOG4105K56 Transcriptional regulator EML4_02445 ENOG4108ZHJ Organic hydroperoxide resistance protein EML4_02460 ENOG4105C5H ABC transporter EML4_02490 ENOG4105EQ2 LysR family Transcriptional regulator EML4_02495 ENOG4105EMU Dehydrogenase EML4_02510 ENOG4105D7A ATP-binding protein EML4_02520 ENOG4105KVH Transcriptional regulator EML4_02525 ENOG4108VHC Short-chain dehydrogenase reductase Sdr EML4_02540 ENOG4105CV8 reductase EML4_02545 ENOG4105FFC UPF0187 protein EML4_02550 ENOG4105D29 Helix-turn-helix type 11 domain protein EML4_02560 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EML4_02565 ENOG4105CM2 brancheD-chain amino acid aminotransferase EML4_02570 ENOG4105C8Q Methyl-accepting chemotaxis EML4_02590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EML4_02605 ENOG4108NIW Leucine export protein LeuE EML4_02610 ENOG4105TAV cytochrome C EML4_02615 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding EML4_02670 ENOG4108IJ7 Glycine betaine EML4_02675 ENOG4108HQS Glycine betaine EML4_02705 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EML4_02715 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EML4_02735 ENOG4108UT2 hemolysin iii EML4_02745 ENOG410829K Lysine exporter protein (Lyse ygga) EML4_02750 ENOG4105E0X reductase EML4_02755 ENOG4105D65 subunit l EML4_02760 ENOG4105HC0 Na H antiporter EML4_02765 ENOG4108ZE9 Monovalent cation H antiporter subunit C EML4_02770 ENOG4108JPZ Monovalent cation H antiporter subunit D EML4_02775 ENOG4105SC1 monovalent cation H antiporter subunit E EML4_02780 ENOG41080TA Multiple resistance and ph regulation protein f EML4_02785 ENOG4105KJM monovalent cation h antiporter subunit g EML4_02790 ENOG4108YXV Transcriptional regulator EML4_02805 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EML4_02810 ENOG4105WZR EML4_02815 ENOG4105BZU Histidine kinase EML4_02855 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EML4_02860 ENOG4108JQC penicillin-binding protein 1A EML4_02865 ENOG4108ZZ3 UPF0260 protein EML4_02915 ENOG4105F27 Major Facilitator EML4_02930 ENOG4105CNG UPF0061 protein EML4_02940 ENOG4105EW9 transcriptional regulator AsnC family EML4_03070 ENOG4105XJC Two component transcriptional regulator (Winged helix family EML4_03085 ENOG4106FI7 cytochrome c-type biogenesis protein EML4_03090 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) EML4_03095 ENOG4105DA4 cytochrome c-type biogenesis protein EML4_03100 ENOG4105KWW Biogenesis protein EML4_03105 ENOG4105C0H protease EML4_03110 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EML4_03115 ENOG4105JJR Histidine kinase EML4_03120 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EML4_03125 ENOG4105Z4Q MltA-interacting MipA family protein EML4_03130 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EML4_03135 ENOG4105BZU Histidine kinase EML4_03145 ENOG4105CD8 aminopeptidase N EML4_03150 ENOG4108EHX EamA-like transporter family EML4_03165 ENOG4105R8A Heat shock protein EML4_03175 ENOG4105CHR reductase EML4_03190 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EML4_03200 ENOG4105CIS alcohol dehydrogenase EML4_03205 ENOG4105KVH Transcriptional regulator EML4_03210 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EML4_03215 ENOG4105CJW magnesium transporter EML4_03220 ENOG4105F27 Major Facilitator EML4_03230 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EML4_03245 ENOG4105FYV Amp nucleosidase EML4_03275 ENOG4105CIH Imidazole acetol-phosphate transaminase EML4_03325 ENOG4107SC1 transglycosylase EML4_03330 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EML4_03335 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EML4_03340 ENOG4105UT3 Methyl-accepting chemotaxis EML4_03350 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EML4_03370 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EML4_03375 ENOG4105C3F Signal peptidase i EML4_03380 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EML4_03385 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EML4_03395 ENOG41074H6 response regulator EML4_03400 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) EML4_03410 ENOG4105DMQ Methyltransferase EML4_03415 ENOG4105QVC MOSC domain-containing protein EML4_03420 ENOG4105EST Metal Dependent Phosphohydrolase EML4_03445 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component EML4_03450 ENOG4108MEK Metal-binding protein YodA EML4_03455 ENOG4105D64 Mechanosensitive ion channel EML4_03465 ENOG4108R7K Metal Dependent Phosphohydrolase EML4_03495 ENOG4105KK4 UPF0060 membrane protein EML4_03510 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EML4_03515 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme EML4_03520 ENOG4108JJ7 ABC transporter EML4_03530 ENOG4108URH decarboxylase EML4_03540 ENOG4105FR1 rard protein EML4_03560 ENOG4105WDY DNA (cytosine-5-)-methyltransferase EML4_03565 ENOG4105C8N cysteinyl-tRNA synthetase EML4_03570 ENOG4105PDP Short chain dehydrogenase EML4_03575 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EML4_03580 ENOG4105E96 Colicin v production protein EML4_03600 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EML4_03605 ENOG4105E7U AraC family transcriptional regulator EML4_03610 ENOG4108UMN azlc family EML4_03620 ENOG4105CDU Replicative dna helicase EML4_03640 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EML4_03650 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EML4_03655 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EML4_03665 ENOG4105CPC Aldo Keto reductase EML4_03670 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EML4_03680 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EML4_03685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EML4_03695 ENOG4105HHA aminodeoxychorismate lyase EML4_03700 ENOG4105DSJ YicC domain protein EML4_03705 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EML4_03720 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EML4_03725 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EML4_03735 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EML4_03750 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EML4_03760 ENOG4105BZU Histidine kinase EML4_03775 ENOG4105BZU Histidine kinase EML4_03780 ENOG4105BZU Histidine kinase EML4_03785 ENOG4108ZXC Two component transcriptional regulator, luxr family EML4_03795 ENOG4105C5H ABC transporter EML4_03800 ENOG4105BZU Histidine kinase EML4_03810 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EML4_03830 ENOG4108ZAF Molybdopterin EML4_03845 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EML4_03850 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EML4_03855 ENOG4105JVC membrAne EML4_03875 ENOG4105D6S protein involved in catabolism of external DNA EML4_03880 ENOG4107QY8 reductase EML4_03885 ENOG4107VIJ nudix hydrolase EML4_03905 ENOG4108V3E phosphoribosylglycinamide formyltransferase EML4_03910 ENOG4105CXB phosphoribosylaminoimidazole synthetase EML4_03920 ENOG4105C02 permease EML4_03930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EML4_03935 ENOG4105C9X ppx gppa phosphatase EML4_03960 ENOG4108Q35 Adenylate EML4_03970 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EML4_03975 ENOG4108ISG Major Facilitator EML4_03980 ENOG4105C9M aspartyl-trna synthetase EML4_03995 ENOG4105CHH sulfate transporter EML4_04005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EML4_04010 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate EML4_04020 ENOG4105D52 delta-aminolevulinic acid dehydratase EML4_04040 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EML4_04045 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EML4_04050 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EML4_04065 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EML4_04070 ENOG4107XZX Involved in the transcription termination process (By similarity) EML4_04075 ENOG4105DXI Major Facilitator superfamily EML4_04080 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for EML4_04100 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EML4_04105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EML4_04110 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EML4_04115 ENOG4105WJX transcriptional regulator MERR family EML4_04145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_04150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_04155 ENOG4105C3U ABC transporter EML4_04165 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_04175 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EML4_04180 ENOG4105C7B Threonine dehydratase EML4_04195 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EML4_04200 ENOG4105HEI LysR family (Transcriptional regulator EML4_04205 ENOG4105CGH 5'-nucleotidase EML4_04225 ENOG4105KHC sulfurtransferase EML4_04240 ENOG4105CVP deoxyribo-dipyrimidine photolyase EML4_04250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EML4_04280 ENOG4108TPP exopolysaccharide synthesis EML4_04285 ENOG4108UM1 dedA family EML4_04330 ENOG4105D3Q Sugar transferase EML4_04335 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase EML4_04360 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) EML4_04370 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EML4_04375 ENOG4105CYW agmatinase EML4_04380 ENOG4108UJD 30S ribosomal protein S9 EML4_04385 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EML4_04395 ENOG4105K4P CoA-binding domain protein EML4_04420 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr EML4_04425 ENOG4106A3M Cytochrome p-450 EML4_04430 ENOG4105BZU Histidine kinase EML4_04435 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EML4_04440 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EML4_04445 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EML4_04480 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EML4_04485 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EML4_04490 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EML4_04500 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EML4_04510 ENOG4105GKE subunit e EML4_04515 ENOG4107QIZ NADH dehydrogenase EML4_04520 ENOG4107R0R NADH dehydrogenase subunit g EML4_04525 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EML4_04530 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EML4_04535 ENOG4105DF2 NADH dehydrogenase subunit j EML4_04540 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EML4_04545 ENOG4105D65 subunit l EML4_04550 ENOG4105C8S subunit m EML4_04555 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EML4_04560 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EML4_04575 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EML4_04585 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EML4_04600 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EML4_04620 ENOG4108UXN response regulator EML4_04630 ENOG4105W0E 50S ribosomal protein L33 EML4_04635 ENOG4108ISG Major Facilitator EML4_04650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EML4_04665 ENOG4105C79 DNA protecting protein DprA EML4_04670 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EML4_04675 ENOG4105CD3 dihydroorotase EML4_04680 ENOG4105CXT aspartate transcarbamylase EML4_04695 ENOG4105CSU acyl-Coa dehydrogenase EML4_04700 ENOG4108ZBR Gcn5-related n-acetyltransferase EML4_04720 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EML4_04725 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EML4_04730 ENOG4107T8T UPF0173 metal-dependent hydrolase EML4_04735 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EML4_04740 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EML4_04745 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EML4_04750 ENOG4105YCT UPF0386 protein EML4_04765 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EML4_04775 ENOG410849A acetyltransferase, (GNAT) family EML4_04795 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EML4_04800 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EML4_04805 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EML4_04810 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EML4_04840 ENOG4105CHR reductase EML4_04845 ENOG4105C03 ribonuclease EML4_04850 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EML4_04875 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EML4_04880 ENOG4105JAB phenazine biosynthesis protein, phzf family EML4_04900 ENOG4107Z7P Ferredoxin EML4_04910 ENOG4105EEI dihydropteroate synthase EML4_04915 ENOG4105KRF dihydroneopterin aldolase EML4_04920 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EML4_04930 ENOG4106K28 UPF0283 membrane protein EML4_04935 ENOG4105CM6 amino acid regulated cytosolic protein EML4_04965 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EML4_05000 ENOG4105K59 histidine triad (HIT) protein EML4_05025 ENOG4105CE9 30S ribosomal protein S2 EML4_05030 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EML4_05035 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EML4_05040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EML4_05045 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EML4_05055 ENOG4105DZP Membrane-associated zinc metalloprotease EML4_05060 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EML4_05065 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EML4_05070 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EML4_05075 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EML4_05080 ENOG4105GYT Protein of unknown function (DUF1009) EML4_05085 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EML4_05090 ENOG41073TP transcriptional regulator EML4_05100 ENOG4105E5Q amino acid AbC transporter EML4_05105 ENOG4105E5Q amino acid AbC transporter EML4_05115 ENOG4105BZN citrate synthase EML4_05130 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EML4_05140 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EML4_05145 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EML4_05155 ENOG4108JYK Dehydrogenase EML4_05160 ENOG4105CPP Dehydrogenase, E1 component EML4_05165 ENOG4105C7S Dehydrogenase EML4_05175 ENOG4107QN2 dihydrolipoyl dehydrogenase EML4_05185 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EML4_05190 ENOG4105DXC membrane EML4_05210 ENOG4108Z1B Cyclase dehydrase EML4_05215 ENOG4105CEV competence damage-inducible protein EML4_05220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EML4_05230 ENOG4105CUX Signal transduction histidine kinase EML4_05235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EML4_05240 ENOG4105ES5 Histidine kinase EML4_05245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EML4_05250 ENOG4105C1A potassium transporter peripheral membrane EML4_05255 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EML4_05260 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EML4_05265 ENOG4105DXN mazG family EML4_05275 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EML4_05295 ENOG4105DP0 ferredoxin-NADP reductase EML4_05315 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EML4_05320 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EML4_05325 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EML4_05350 ENOG41082CG Protein CrcB homolog EML4_05355 ENOG4105EI2 Pseudouridine synthase EML4_05360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EML4_05375 ENOG4108UQ8 endoribonuclease L-psp EML4_05380 ENOG4105C4W S-formylglutathione hydrolase EML4_05390 ENOG4108UPT UPF0178 protein EML4_05405 ENOG4105D3R alkyl hydroperoxide reductase EML4_05415 ENOG4105CYM Glutathione S-transferase EML4_05435 ENOG4105F9F transposase EML4_05440 ENOG4105CAU Arsenical resistance protein, ArsH EML4_05450 ENOG4105D6J arsenicaL-resistance protein EML4_05470 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EML4_05475 ENOG4105F8V Hydrolase, tatD family EML4_05480 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EML4_05485 ENOG4107QRG dna polymerase iii EML4_05490 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EML4_05495 ENOG4105DZ1 carboxypeptidase EML4_05545 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EML4_05550 ENOG41081FY multiple antibiotic resistance (MarC)-related EML4_05565 ENOG4108UUM single-stranded DNA-binding protein EML4_05570 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EML4_05580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EML4_05590 ENOG4108Z0R Transferase EML4_05600 ENOG4105FAV ABC, transporter EML4_05605 ENOG4105FDK ABC transporter EML4_05615 ENOG4105ETE Transcriptional regulator (LacI family EML4_05625 ENOG4105CPC Aldo Keto reductase EML4_05635 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EML4_05715 ENOG4105CJW magnesium transporter EML4_05720 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EML4_05730 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EML4_05745 ENOG4105BZU Histidine kinase EML4_05755 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EML4_05760 ENOG4105DQ4 alcohol dehydrogenase EML4_05790 ENOG4105VIE preprotein translocase, subunit YajC EML4_05800 ENOG4105E2A Dehydrogenase EML4_05805 ENOG41062JF Transcriptional regulator EML4_05820 ENOG4105D7W serine acetyltransferase EML4_05835 ENOG4105MSY salicylate hydroxylase EML4_05840 ENOG4105C28 cystathionine EML4_05845 ENOG4107QXX ABC transporter EML4_05850 ENOG4105EZ7 amino acid ABC transporter EML4_05855 ENOG4105DRP amino acid AbC transporter EML4_05860 ENOG4105CDA abc transporter atp-binding protein EML4_05880 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EML4_05890 ENOG4105D6E homoserine dehydrogenase EML4_05895 ENOG4105CHM Aminotransferase EML4_05925 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EML4_05935 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EML4_05940 ENOG4105J3Q acyl carrier protein EML4_05945 ENOG4105D4P Coproporphyrinogen iii oxidase EML4_05950 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EML4_05960 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class EML4_05965 ENOG4105PW4 Sugar fermentation stimulation protein homolog EML4_05970 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EML4_05990 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase EML4_06015 ENOG4105E66 phosphoriboisomerase A EML4_06020 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EML4_06030 ENOG4105C9Q fumarate hydratase class II EML4_06040 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EML4_06045 ENOG4107EJC Preprotein translocase subunit SecG EML4_06050 ENOG4105CP7 Triose-phosphate isomerase EML4_06060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EML4_06070 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EML4_06080 ENOG4105KBH arsR family transcriptional regulator EML4_06085 ENOG4107RZC phospholipase d EML4_06110 ENOG4105EGS Mechanosensitive ion channel EML4_06175 ENOG4105DHJ ABC, transporter EML4_06180 ENOG4105CY3 ABC transporter, permease EML4_06185 ENOG4107S8C mandelate racemase muconate lactonizing EML4_06195 ENOG4105C6K Malic enzyme EML4_06205 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase EML4_06210 ENOG4108MR6 WD40-like Beta Propeller Repeat EML4_06220 ENOG4105C4K Nad synthetase EML4_06225 ENOG4107T7U Sulfatase EML4_06250 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EML4_06270 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EML4_06290 ENOG4107QPD alcohol dehydrogenase EML4_06305 ENOG4105CEY Amp-dependent synthetase and ligase EML4_06320 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EML4_06325 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EML4_06340 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EML4_06355 ENOG4108I0Q anthranilate phosphoribosyltransferase EML4_06360 ENOG4105DK0 Indole-3-glycerol phosphate synthase EML4_06365 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EML4_06370 ENOG4105CVM Molybdenum cofactor synthesis domain protein EML4_06375 ENOG4105BZU Histidine kinase EML4_06385 ENOG4105CKD glutathione-regulated potassium-efflux system protein EML4_06395 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EML4_06405 ENOG4105CZQ inner membrane transport protein YdhC EML4_06410 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EML4_06415 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b EML4_06420 ENOG4105DR5 peptidase EML4_06425 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EML4_06430 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EML4_06435 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EML4_06440 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EML4_06450 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EML4_06455 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EML4_06460 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EML4_06465 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EML4_06475 ENOG4105C75 arginyL-tRNA synthetase EML4_06480 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EML4_06495 ENOG4108UQD Sel1 domain protein repeat-containing protein EML4_06505 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EML4_06515 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EML4_06545 ENOG4105CS1 NAD(P)H quinone oxidoreductase EML4_06550 ENOG4107TH8 cina domain protein EML4_06560 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) EML4_06570 ENOG4107RTZ reductase EML4_06580 ENOG4108A65 Transcriptional regulator EML4_06585 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EML4_06595 ENOG4105BZ1 (ABC) transporter EML4_06600 ENOG4105IPI Membrane EML4_06635 ENOG4105C22 threonyL-tRNA synthetase EML4_06645 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EML4_06655 ENOG4105EUJ GTP cyclohydrolase i EML4_06660 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EML4_06665 ENOG4105D78 K07001 NTE family protein EML4_06675 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EML4_06710 ENOG4105EJQ L-serine dehydratase EML4_06755 ENOG4105ECQ AraC Family Transcriptional Regulator EML4_06760 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EML4_06775 ENOG4105C5F glutamine synthetase EML4_06785 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) EML4_06805 ENOG4108JHT EamA-like transporter family EML4_06825 ENOG4105CB5 ATP-dependent DNA helicase recG EML4_06855 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EML4_06865 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EML4_06870 ENOG4107EJG GntR family transcriptional regulator EML4_06885 ENOG4105UIB (ABC) transporter EML4_06890 ENOG4105C2J ABC transporter EML4_06895 ENOG4105VE1 Phosphatidylcholine synthase EML4_06905 ENOG4105RK9 auxin efflux carrier EML4_06910 ENOG4107QIV Cytochrome c biogenesis protein EML4_06995 ENOG4108R7K Metal Dependent Phosphohydrolase EML4_07110 ENOG4108Z9Z response to DNA damage stimulus EML4_07125 ENOG4105K8R UPF0145 protein EML4_07185 ENOG4105D07 Signal peptide peptidase, SppA EML4_07240 ENOG4105D9P serine threonine protein kinase EML4_07250 ENOG4105VDW Csbd family EML4_07260 ENOG4107RHI Cytosine-specific methyltransferase EML4_07290 ENOG4105CFI type iii restriction protein res subunit EML4_07295 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EML4_07405 ENOG4108I1J Integrase EML4_07425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EML4_07430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EML4_07450 ENOG4105QAS Iron-sulfur cluster assembly accessory protein EML4_07455 ENOG4105VG1 fes assembly suf system protein EML4_07465 ENOG4105JRK feS assembly protein SufD EML4_07480 ENOG4105C3J Cysteine desulfurase EML4_07485 ENOG4105DHZ alpha beta EML4_07490 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EML4_07495 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EML4_07505 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EML4_07510 ENOG4105ED9 Protein of unknown function (DUF455) EML4_07515 ENOG4105DR5 peptidase EML4_07520 ENOG4105C1J atp-dependent rna helicase EML4_07535 ENOG4105DJV ribulose-phosphate 3-epimerase EML4_07545 ENOG4105C83 adenylosuccinate lyase EML4_07555 ENOG4107QPR SAICAR synthetase EML4_07560 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EML4_07565 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EML4_07580 ENOG4107SQD Transcriptional regulator, GntR family EML4_07585 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EML4_07615 ENOG4105C2C drug resistance transporter, Bcr CflA EML4_07620 ENOG4105ECY inositol monophosphatase EML4_07625 ENOG4108MWI inositol mono-phosphatase EML4_07630 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EML4_07635 ENOG4105CSV Glutaminase EML4_07640 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EML4_07645 ENOG4105DU1 integral membrane protein, terc EML4_07655 ENOG4108594 Permease of the drug metabolite transporter EML4_07660 ENOG410829K Lysine exporter protein (Lyse ygga) EML4_07670 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EML4_07675 ENOG4105CVS RNA methyltransferase TrmH family, group 1 EML4_07695 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EML4_07700 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EML4_07705 ENOG4107UH8 sugar kinase EML4_07710 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EML4_07720 ENOG4106TNF Periplasmic binding protein EML4_07725 ENOG4105GBT ABC transporter EML4_07735 ENOG4105P0T Usg family EML4_07745 ENOG4105GVF (ABC) transporter EML4_07750 ENOG4108XM1 transcriptional regulator AsnC family EML4_07755 ENOG4108RG0 uracil-dna glycosylase EML4_07765 ENOG4105BZU Histidine kinase EML4_07770 ENOG41085FU Diacylglycerol kinase EML4_07775 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) EML4_07780 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) EML4_07795 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EML4_07800 ENOG4105E3A (ABC) transporter EML4_07805 ENOG4105DA5 (ABC) transporter EML4_07830 ENOG4105D1H recombination factor protein RarA EML4_07835 ENOG4105C0H protease EML4_07855 ENOG4105C01 Dihydroxy-acid dehydratase EML4_07860 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EML4_07865 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EML4_07875 ENOG4105NX3 Membrane EML4_07885 ENOG4108ZT0 50S ribosomal protein l17 EML4_07890 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EML4_07895 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EML4_07900 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EML4_07905 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EML4_07910 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EML4_07915 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EML4_07920 ENOG41084HQ 50S ribosomal protein L30 EML4_07925 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EML4_07930 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EML4_07935 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EML4_07940 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EML4_07945 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EML4_07950 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EML4_07955 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EML4_07960 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EML4_07965 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EML4_07970 ENOG41083MP 50s ribosomal protein l29 EML4_07975 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EML4_07980 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EML4_07985 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EML4_07990 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EML4_07995 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EML4_08000 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EML4_08005 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EML4_08010 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EML4_08015 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EML4_08020 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EML4_08025 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EML4_08030 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EML4_08035 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EML4_08055 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EML4_08060 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EML4_08065 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EML4_08070 ENOG4108VZM 50s ribosomal protein L10 EML4_08075 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EML4_08080 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EML4_08090 ENOG410683Z Preprotein translocase SecE subunit EML4_08100 ENOG4105C5E polysaccharide biosynthesis protein EML4_08105 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EML4_08110 ENOG4108ZCF integral membrane protein EML4_08115 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme EML4_08135 ENOG4105BZ1 (ABC) transporter EML4_08140 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EML4_08160 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EML4_08190 ENOG4107QQR Sporulation EML4_08195 ENOG4105BZU Histidine kinase EML4_08200 ENOG41074H6 response regulator EML4_08205 ENOG4105BZU Histidine kinase EML4_08215 ENOG4105BZU Histidine kinase EML4_08230 ENOG4105C2N RNA methyltransferase TrmH family group 3 EML4_08235 ENOG4105NAU thioesterase Superfamily protein EML4_08255 ENOG4108RYK Nad-dependent epimerase dehydratase EML4_08260 ENOG4105KVH Transcriptional regulator EML4_08275 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EML4_08285 ENOG4105DYC esterase EML4_08305 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EML4_08325 ENOG4105BZU Histidine kinase EML4_08335 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_08345 ENOG4107QKW extracellular solute-binding protein family 1 EML4_08350 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EML4_08365 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EML4_08375 ENOG4105CF7 AraC family transcriptional regulator EML4_08380 ENOG4105DQ4 alcohol dehydrogenase EML4_08385 ENOG4105CEP NADH dehydrogenase EML4_08390 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EML4_08395 ENOG4105VJY transcriptional regulator EML4_08400 ENOG4107SID ATP-dependent exodnase (exonuclease v) EML4_08435 ENOG4105CV8 reductase EML4_08450 ENOG4108ZP8 Acetolactate synthase small subunit EML4_08455 ENOG4105C7K acetolactate synthase EML4_08470 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EML4_08475 ENOG4105EAC phosphoserine phosphatase EML4_08480 ENOG4108YYQ gCN5-related N-acetyltransferase EML4_08495 ENOG4105EPW hflc protein EML4_08500 ENOG4107QJR hflk protein EML4_08510 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EML4_08545 ENOG4105CQB FAD linked oxidase domain protein EML4_08550 ENOG4105BZS acriflavin resistance protein EML4_08555 ENOG4105ENT Efflux transporter rnd family, mfp subunit EML4_08590 ENOG4108RWI nicotinamidase EML4_08620 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EML4_08625 ENOG4108ZX6 Electron transport protein SCO1 SenC EML4_08635 ENOG4108V3W Chemotaxis protein, CheW EML4_08645 ENOG41083X2 DNA polymerase III, epsilon subunit EML4_08650 ENOG4105ETT transcriptional Regulator, LysR family EML4_08660 ENOG4105WCN acetyltransferase EML4_08670 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EML4_08675 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EML4_08680 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EML4_08690 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EML4_08695 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EML4_08700 ENOG4108UFP Essential cell division protein (By similarity) EML4_08705 ENOG4105CPF Cell wall formation (By similarity) EML4_08710 ENOG4105CSH Transporter EML4_08715 ENOG4105BZU Histidine kinase EML4_08720 ENOG4105D4A Cell wall formation (By similarity) EML4_08725 ENOG4105DFU Cell wall formation (By similarity) EML4_08730 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EML4_08740 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EML4_08745 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EML4_08755 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EML4_08770 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EML4_08775 ENOG4107YUR Cell division protein mraZ EML4_08800 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EML4_08830 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EML4_08845 ENOG4105SYT Methylenetetrahydrofolate reductase EML4_08850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EML4_08860 ENOG4105E5G Alpha beta hydrolase fold EML4_08865 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EML4_08895 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein EML4_08900 ENOG4105EQ0 Major Facilitator superfamily EML4_08935 ENOG4105C26 Dehydrogenase EML4_08940 ENOG4105C5F glutamine synthetase EML4_08945 ENOG4105CUB amino acid EML4_08960 ENOG4107FKK extracellular solute-binding protein family 1 EML4_08975 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_09000 ENOG4105C3R Methionine synthase EML4_09005 ENOG4107QKS N-acylglucosamine 2-epimerase EML4_09035 ENOG4105MPN Membrane EML4_09050 ENOG4105BZU Histidine kinase EML4_09060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EML4_09065 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EML4_09085 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EML4_09090 ENOG4107QI1 Mate efflux family protein EML4_09095 ENOG4105C8Q Methyl-accepting chemotaxis EML4_09105 ENOG4105CGZ zinc metallopeptidase EML4_09120 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EML4_09130 ENOG4105BZU Histidine kinase EML4_09145 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EML4_09155 ENOG4105F7P transcriptional regulator AsnC family EML4_09160 ENOG4105C3M thioredoxin reductase EML4_09165 ENOG4105CBN LysR family transcriptional regulator EML4_09175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EML4_09210 ENOG4108KMM Diguanylate cyclase EML4_09230 ENOG4105C5X domain protein EML4_09240 ENOG41090HR transcriptional regulator EML4_09245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EML4_09250 ENOG4105E0F Histidine kinase EML4_09255 ENOG4108Z7R Chaperone CsaA EML4_09260 ENOG4105II7 pyrroline-5-carboxylate reductase EML4_09275 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EML4_09285 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EML4_09300 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EML4_09310 ENOG4107G9V glycosyl transferase, family 39 EML4_09330 ENOG4105C26 Dehydrogenase EML4_09335 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EML4_09340 ENOG4105BZU Histidine kinase EML4_09345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EML4_09360 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EML4_09370 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EML4_09375 ENOG4105C3G gtp-binding protein EML4_09395 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EML4_09405 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EML4_09415 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EML4_09425 ENOG4105BZ1 (ABC) transporter EML4_09430 ENOG4105BZ1 (ABC) transporter EML4_09440 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EML4_09445 ENOG4105EAM Na Pi-cotransporter EML4_09455 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EML4_09470 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EML4_09475 ENOG4105P8F nudix hydrolase EML4_09485 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EML4_09505 ENOG4105VEV -acetyltransferase EML4_09520 ENOG41079KZ Major Facilitator Superfamily EML4_09530 ENOG4105CHF Glutathione S-transferase EML4_09535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EML4_09545 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EML4_09550 ENOG4105DKK Benzoate EML4_09575 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EML4_09590 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EML4_09615 ENOG41080HT Transcriptional regulator, arsr family EML4_09620 ENOG4108IJ7 Glycine betaine EML4_09640 ENOG4107104 thymidine kinase EML4_09675 ENOG4105CRQ synthase (Component I) EML4_09685 ENOG4105CPI Metal Dependent Phosphohydrolase EML4_09690 ENOG4105CPN adenine deaminase EML4_09700 ENOG4105CG3 alpha amylase, catalytic region EML4_09705 ENOG4107SS6 2-dehydro-3-deoxygluconokinase EML4_09725 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EML4_09755 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EML4_09775 ENOG4105C7W Xanthine dehydrogenase EML4_09785 ENOG4105ETT transcriptional Regulator, LysR family EML4_09800 ENOG4107QUY Guanine deaminase EML4_09810 ENOG4105DMF Dehydrogenase EML4_09820 ENOG4108RZE Tetr family transcriptional regulator EML4_09825 ENOG4105DZ1 carboxypeptidase EML4_09840 ENOG4108Z2U ureidoglycolate hydrolase EML4_09855 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) EML4_09865 ENOG4108TXN phosphonate metabolism protein EML4_09870 ENOG41087SS fad dependent oxidoreductase EML4_09875 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EML4_09880 ENOG4105BZU Histidine kinase EML4_09885 ENOG4105C1J atp-dependent rna helicase EML4_09895 ENOG4105EQR Transposase IS116 IS110 IS902 EML4_09900 ENOG4105MGM doxx family EML4_09905 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein EML4_09955 ENOG4108HWW ABC transporter EML4_09960 ENOG4105C2J ABC transporter EML4_09965 ENOG4105DFW ABC transporter EML4_10095 ENOG4105C3R Methionine synthase EML4_10105 ENOG4105DSP amino acid AbC transporter EML4_10115 ENOG4108JEH abc transporter atp-binding protein EML4_10195 ENOG4108R86 Transcriptional regulator EML4_10200 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EML4_10205 ENOG4105CD3 dihydroorotase EML4_10210 ENOG4105M6F mutator MutT protein EML4_10220 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EML4_10225 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EML4_10255 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) EML4_10260 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EML4_10265 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) EML4_10280 ENOG4105CQM Urea amidohydrolase subunit alpha EML4_10285 ENOG4106ISJ urease accessory protein EML4_10300 ENOG4105KI2 Urea amidohydrolase subunit beta EML4_10305 ENOG4105XDF Protein of unknown function (DUF1272) EML4_10310 ENOG4108YZ9 Urea amidohydrolase subunit gamma EML4_10315 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) EML4_10325 ENOG4108IV0 ABC, transporter EML4_10335 ENOG4105C0Z ABC transporter EML4_10345 ENOG4105C32 Amino acid ABC transporter (Permease) EML4_10360 ENOG4107R5B glutamine synthetase EML4_10365 ENOG4105CHR reductase EML4_10370 ENOG4105BZU Histidine kinase EML4_10375 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase EML4_10385 ENOG4108ZJ4 polysaccharide deacetylase EML4_10400 ENOG4108IV0 ABC, transporter EML4_10405 ENOG4105C0Z ABC transporter EML4_10410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EML4_10420 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EML4_10505 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EML4_10515 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EML4_10540 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EML4_10550 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EML4_10555 ENOG4107XDR Lactoylglutathione lyase EML4_10560 ENOG4105WD1 Membrane EML4_10565 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EML4_10570 ENOG4105EHG Permease protein EML4_10575 ENOG4107R4I Periplasmic binding protein EML4_10585 ENOG41090JE Utilization Protein EML4_10600 ENOG4105VMP Transcriptional regulator EML4_10615 ENOG4105VUH addiction module killer protein EML4_10625 ENOG41062D9 Histidine kinase EML4_10670 ENOG4105DHS permease protein EML4_10675 ENOG4105CM4 permease protein EML4_10680 ENOG4108IPW abc transporter atp-binding protein EML4_10685 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction EML4_10705 ENOG4105CV8 reductase EML4_10710 ENOG4105F27 Major Facilitator EML4_10715 ENOG4105EXG Transcriptional regulator EML4_10720 ENOG4105CC0 LysR family Transcriptional regulator EML4_10730 ENOG4105ENT Efflux transporter rnd family, mfp subunit EML4_10750 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EML4_10755 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) EML4_10760 ENOG4107B2H carbonic anhydrase EML4_10770 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EML4_10785 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EML4_10790 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EML4_10795 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EML4_10800 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) EML4_10805 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EML4_10810 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) EML4_10815 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) EML4_10820 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) EML4_10825 ENOG4108YNN Heme oxygenase EML4_10830 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EML4_10850 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_10860 ENOG4108MGF sugar kinase EML4_10870 ENOG4105F0I Aminotransferase EML4_10875 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EML4_10885 ENOG4108JQ7 (ABC) transporter EML4_10895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_10900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_10905 ENOG4108J59 Extracellular solute-binding protein, family 5 EML4_10910 ENOG4108IGT Dipeptidase EML4_10955 ENOG4105KHM amidohydrolase 2 EML4_10960 ENOG4108KC1 acyl-Coa dehydrogenase EML4_10990 ENOG4105ETX regulatoR EML4_11005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_11010 ENOG4107RCV ABC transporter, permease EML4_11015 ENOG4105C4Y ABC transporter EML4_11020 ENOG4105C4Y ABC transporter EML4_11025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EML4_11095 ENOG4105C8V SAICAR synthetase EML4_11105 ENOG4105C1P efflux transporter, rnd family, mfp subunit EML4_11110 ENOG4105BZS acriflavin resistance protein EML4_11120 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EML4_11125 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EML4_11145 ENOG4105CBN LysR family transcriptional regulator EML4_11150 ENOG4105CJP fad dependent oxidoreductase EML4_11155 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EML4_11160 ENOG4105E0C molybdate abc transporter EML4_11165 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EML4_11180 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EML4_11195 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EML4_11200 ENOG410609C Acyl carrier protein EML4_11230 ENOG4105BZ1 (ABC) transporter EML4_11235 ENOG4105IJJ transcriptional regulator, crp fnr family EML4_11255 ENOG4107QQG Dehydrogenase EML4_11280 ENOG4107QSI ABC, transporter EML4_11285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_11290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_11305 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EML4_11310 ENOG4106N3A copper homeostasis protein cutc EML4_11315 ENOG4105S8Q sugar efflux transporter EML4_11325 ENOG4105E2D ec 3.2.1.52 EML4_11330 ENOG4108KEZ Dehydrogenase EML4_11335 ENOG4106KNT transcriptional regulator EML4_11345 ENOG4108IJ9 (ABC) transporter EML4_11355 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_11380 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EML4_11385 ENOG4105CE4 GlcNAc 6-P deacetylase EML4_11390 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) EML4_11400 ENOG4105YVM Phosphoesterase, PA-phosphatase related EML4_11405 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EML4_11410 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EML4_11420 ENOG4105CFU surface antigen EML4_11430 ENOG4108V3W Chemotaxis protein, CheW EML4_11435 ENOG4107SDU Methyl-accepting chemotaxis EML4_11440 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EML4_11445 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EML4_11450 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EML4_11455 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EML4_11460 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EML4_11465 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EML4_11475 ENOG4105C25 Primosomal protein n' EML4_11480 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EML4_11500 ENOG4107QN2 dihydrolipoyl dehydrogenase EML4_11505 ENOG4105N14 lysine exporter protein LysE YggA EML4_11515 ENOG4105C7S Dehydrogenase EML4_11520 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EML4_11525 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EML4_11530 ENOG4105CMV Succinyl-CoA synthetase subunit beta EML4_11535 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EML4_11540 ENOG4105D6Z AFG1 family ATPase EML4_11545 ENOG4105YU5 Outer membrane lipoprotein EML4_11550 ENOG4105E33 succinate dehydrogenase EML4_11555 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EML4_11565 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) EML4_11575 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EML4_11590 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EML4_11595 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EML4_11600 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EML4_11625 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EML4_11640 ENOG410856B UPF0235 protein EML4_11645 ENOG4105F0N pyrophosphate phospho-hydrolase EML4_11655 ENOG4105CI3 gtp-binding protein typa EML4_11660 ENOG4105DGW oligopeptidase A EML4_11665 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) EML4_11675 ENOG4105CDH Citrulline--aspartate ligase EML4_11685 ENOG410829K Lysine exporter protein (Lyse ygga) EML4_11695 ENOG4105C7J ABC transporter, permease EML4_11705 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EML4_11720 ENOG4105KZX Pterin carbinolamine dehydratase EML4_11730 ENOG4105M7V 2'-5' rna ligase EML4_11740 ENOG4108I0Y (ABC) transporter EML4_11750 ENOG4105HFZ Membrane EML4_11765 ENOG4107QM5 aconitate hydratase EML4_11770 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EML4_11775 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EML4_11780 ENOG41060IM Heme exporter protein EML4_11795 ENOG4106TD9 Diguanylate cyclase EML4_11800 ENOG4108VRQ UPF0314 protein EML4_11805 ENOG4107835 probably involved in intracellular septation (By similarity) EML4_11810 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EML4_11815 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EML4_11820 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EML4_11835 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EML4_11840 ENOG4105EHE chorismate mutase- prephenate dehydrogenase EML4_11845 ENOG4105K5M 30s ribosomal protein S16 EML4_11850 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EML4_11855 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EML4_11865 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EML4_11890 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EML4_11905 ENOG4105ERG peptidase m48, ste24p EML4_11910 ENOG4107T0D ABC, transporter EML4_11930 ENOG4105C5H ABC transporter EML4_11940 ENOG4105CVG Homoserine O-transsuccinylase EML4_11945 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EML4_11950 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase EML4_11955 ENOG4105CTB Polyprenyl synthetase EML4_11960 ENOG4108ZG0 Ompa motb domain protein EML4_11965 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EML4_11970 ENOG4106UW1 Major Facilitator superfamily EML4_11975 ENOG4105MVE transcriptional regulator EML4_11980 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EML4_11985 ENOG4105WH1 Two component transcriptional regulator luxr family EML4_11990 ENOG4105BZ1 (ABC) transporter EML4_11995 ENOG4105E2V Glycosyltransferase 36 EML4_12000 ENOG4105CH2 amidohydrolase EML4_12010 ENOG4105D5U fad dependent oxidoreductase EML4_12025 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EML4_12030 ENOG4105EXW epimerase dehydratase EML4_12035 ENOG4105CQB FAD linked oxidase domain protein EML4_12040 ENOG4107YCY Transcriptional regulator EML4_12050 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EML4_12055 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_12060 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EML4_12065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EML4_12075 ENOG4105DFA alanine racemase domain protein EML4_12080 ENOG4105C8T Leucyl-tRNA synthetase EML4_12095 ENOG4108Z4U Ferredoxin EML4_12100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EML4_12120 ENOG4105C29 acyl-CoA thioesterase EML4_12125 ENOG4108YZA Nitrogen regulatory protein pii EML4_12130 ENOG4105BZU Histidine kinase EML4_12135 ENOG4105CNU cell division protein FtsK EML4_12140 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EML4_12155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EML4_12165 ENOG4108VJ1 Transcriptional regulator (CarD family EML4_12170 ENOG4105C7I Dehydrogenase EML4_12175 ENOG4105DEU major facilitator superfamily EML4_12190 ENOG4105CHR reductase EML4_12205 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EML4_12210 ENOG4105PXI polysaccharide deacetylase EML4_12215 ENOG4105CN1 protease EML4_12225 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EML4_12235 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EML4_12240 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EML4_12245 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EML4_12250 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EML4_12265 ENOG4105K46 50S ribosomal protein l27 EML4_12270 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EML4_12295 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EML4_12300 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EML4_12310 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EML4_12320 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) EML4_12385 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) EML4_12395 ENOG4105EFT decarboxylase EML4_12400 ENOG4105DIA mandelate racemase muconate lactonizing EML4_12405 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) EML4_12410 ENOG4107QZW Altronate oxidoreductase EML4_12415 ENOG4105CPQ Dehydrogenase EML4_12435 ENOG4105CNN ABC, transporter EML4_12440 ENOG4105C2J ABC transporter EML4_12445 ENOG4107YCY Transcriptional regulator EML4_12450 ENOG4105CTX dehydratase EML4_12455 ENOG4105DC1 bifunctional purine biosynthesis protein purh EML4_12470 ENOG4105D0M Protease HtpX homolog EML4_12490 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) EML4_12495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EML4_12500 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EML4_12505 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EML4_12510 ENOG4108YXA Membrane EML4_12515 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EML4_12520 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EML4_12525 ENOG4108UHJ MAF-like protein EML4_12530 ENOG4105E2X shikimate dehydrogenase EML4_12535 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EML4_12540 ENOG4107RZZ dna polymerase iii epsilon subunit EML4_12545 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) EML4_12550 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EML4_12560 ENOG4105CA3 membrane-bound lytic murein transglycosylase EML4_12585 ENOG4105ERH Fumarylacetoacetate hydrolase EML4_12600 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EML4_12605 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EML4_12610 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EML4_12615 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EML4_12630 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EML4_12640 ENOG4108S0S Nucleotidyl transferase EML4_12645 ENOG4105K8N protein family UPF0079, ATPase EML4_12650 ENOG4105I8F Histidine kinase EML4_12655 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) EML4_12660 ENOG41080Z8 PHOSPHOCARRIER protein EML4_12665 ENOG4105DAS pts system EML4_12670 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EML4_12675 ENOG4105EB3 Histidine kinase EML4_12680 ENOG4105E3W Two component transcriptional regulator (Winged helix family EML4_12685 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EML4_12690 ENOG4108YZN class I peptide chain release factor EML4_12695 ENOG4109066 lysm domain bon superfamily protein EML4_12700 ENOG4105CS9 pantothenic acid kinase EML4_12705 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase EML4_12710 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EML4_12715 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EML4_12720 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EML4_12730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EML4_12735 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EML4_12740 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EML4_12750 ENOG4107QP3 malate synthase g EML4_12765 ENOG4108UYB regulatoR EML4_12770 ENOG4105TX3 Histidine kinase EML4_12775 ENOG4105CQ7 ATP-dependent helicase EML4_12810 ENOG4105C9U ATP-dependent DNA helicase RecQ EML4_12815 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) EML4_12820 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator EML4_12825 ENOG4105CNN ABC, transporter EML4_12830 ENOG4105C2J ABC transporter EML4_12835 ENOG4105CS9 pantothenic acid kinase EML4_12840 ENOG4105WAZ (Glutaredoxin-like protein) NrdH EML4_12845 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EML4_12865 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EML4_12905 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EML4_12910 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EML4_12915 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EML4_12920 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EML4_12925 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EML4_12930 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EML4_12945 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EML4_12950 ENOG4107SFI Major Facilitator superfamily EML4_12955 ENOG4105CVE Lytic murein transglycosylase EML4_12960 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EML4_12970 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EML4_12975 ENOG4107QMP dna polymerase iii subunits gamma and tau EML4_12990 ENOG4105E09 nadh pyrophosphatase EML4_12995 ENOG4105CQC Prephenate dehydratase EML4_13000 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) EML4_13005 ENOG4105G9V cytochrome C EML4_13015 ENOG4108JQC penicillin-binding protein 1A EML4_13020 ENOG4108UIN ybak prolyl-trna synthetase associated region EML4_13030 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EML4_13040 ENOG4105C2M dna polymerase I EML4_13045 ENOG41082R8 50S ribosomal protein l32 EML4_13050 ENOG4105CQZ Histidine kinase EML4_13055 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EML4_13075 ENOG41069P5 Protein slyX homolog EML4_13085 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EML4_13090 ENOG4105CFG Acts as a chaperone (By similarity) EML4_13105 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EML4_13110 ENOG4105DIH basic membrane EML4_13115 ENOG4108JQ9 ABC transporter EML4_13130 ENOG4105KG3 cytidine deaminase EML4_13135 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EML4_13140 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EML4_13145 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EML4_13155 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EML4_13160 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EML4_13165 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EML4_13175 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EML4_13180 ENOG4105CCU oxidase (Subunit III) EML4_13185 ENOG4105BZ9 Cytochrome C oxidase, subunit I EML4_13190 ENOG4105E2S oxidase) subunit II EML4_13195 ENOG4105CSH Transporter EML4_13200 ENOG4105CBC glutamate synthase EML4_13205 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EML4_13220 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EML4_13230 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) EML4_13240 ENOG4105EN6 Membrane EML4_13260 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EML4_13280 ENOG4108ZZF transport protein (ExbD) EML4_13290 ENOG4105DG4 malate L-lactate dehydrogenase EML4_13305 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) EML4_13310 ENOG4105FD8 phosphonate metabolism protein PhnM EML4_13315 ENOG4108TXN phosphonate metabolism protein EML4_13325 ENOG4105S7S phosphonate abc transporter EML4_13330 ENOG4105EHI Phosphonate ABC transporter, periplasmic EML4_13335 ENOG4105D5T phosphonate abc transporter EML4_13345 ENOG4105HRV phosphonate c-p lyase system protein phnl EML4_13350 ENOG4105ENV phosphonate C-P lyase system protein PhnK EML4_13380 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EML4_13385 ENOG4105CHC glucokinase (EC 2.7.1.2) EML4_13390 ENOG4108Z5K methylglyoxal synthase EML4_13395 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) EML4_13405 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EML4_13410 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EML4_13415 ENOG4108JQ5 ABC transporter EML4_13420 ENOG4105MWK D-amino acid dehydrogenase, small subunit EML4_13425 ENOG4105CFQ glutamine synthetase EML4_13430 ENOG4105CJP fad dependent oxidoreductase EML4_13435 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EML4_13440 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component EML4_13445 ENOG4108IJ8 ABC transporter EML4_13450 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component EML4_13455 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system EML4_13465 ENOG4105KPV Transcriptional regulator EML4_13475 ENOG4105D0M Protease HtpX homolog EML4_13480 ENOG4108M3P Membrane EML4_13485 ENOG4105C26 Dehydrogenase EML4_13495 ENOG4105DFI Membrane EML4_13510 ENOG4107SN7 NLP P60 protein EML4_13520 ENOG4107RH7 Nicotinate phosphoribosyltransferase EML4_13525 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EML4_13600 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EML4_13605 ENOG4105KWI UPF0339 protein EML4_13610 ENOG4108UQ1 hydrolase, family 25 EML4_13615 ENOG4105T38 integral membrane protein EML4_13620 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EML4_13635 ENOG4105CAY ferredoxin--nadp reductase EML4_13650 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EML4_13685 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) EML4_13690 ENOG4105CH5 extracellular solute-binding protein, family 7 EML4_13715 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EML4_13720 ENOG41082BR 50S ribosomal protein L35 EML4_13725 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EML4_13735 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EML4_13740 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EML4_13745 ENOG4105CPC Aldo Keto reductase EML4_13750 ENOG4105EQ2 LysR family Transcriptional regulator EML4_13790 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EML4_13795 ENOG4105CXK mandelate racemase muconate lactonizing EML4_13805 ENOG4108ZT1 Transcriptional regulator EML4_13810 ENOG4108KTG Membrane protein, drug metabolite transporter EML4_13815 ENOG4105C88 aminopeptidase EML4_13820 ENOG4108Z66 YbaK ebsC protein EML4_13825 ENOG4105KUZ arsenate reductase EML4_13845 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) EML4_13855 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EML4_13870 ENOG4105KAV tspo and mbr like protein EML4_13895 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EML4_13900 ENOG4105K6T rare lipoprotein A EML4_13910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EML4_13920 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EML4_13935 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EML4_13945 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EML4_13955 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EML4_13960 ENOG41082FP UPF0102 protein EML4_13985 ENOG4108IJ9 (ABC) transporter EML4_13995 ENOG4105D7Z glutathione synthase EML4_14000 ENOG4105C0P Mg chelatase subunit ChlI EML4_14010 ENOG410829K Lysine exporter protein (Lyse ygga) EML4_14015 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EML4_14020 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EML4_14025 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EML4_14040 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EML4_14045 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EML4_14050 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EML4_14055 ENOG4105E39 Enoyl-CoA hydratase EML4_14060 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EML4_14190 ENOG41090BB DNA mismatch endonuclease (vsr) EML4_14245 ENOG4105CS6 Rhs element vgr protein EML4_14255 ENOG4106178 UPF0339 protein EML4_14280 ENOG4105J7D transcriptional regulator EML4_14300 ENOG4105Y49 secretion protein, HlyD family EML4_14315 ENOG4105D8X mechanosensitive ion channel EML4_14330 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein EML4_14340 ENOG4105CP9 extracellular ligand-binding receptor EML4_14345 ENOG4105C32 Amino acid ABC transporter (Permease) EML4_14355 ENOG4105C0Z ABC transporter EML4_14360 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EML4_14370 ENOG4105C0A alcohol dehydrogenase EML4_14375 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_14380 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_14390 ENOG4108JQ7 (ABC) transporter EML4_14395 ENOG4105E98 transcriptional regulator DeoR family EML4_14400 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EML4_14420 ENOG4105CPD ethanolamine ammonia-lyase EML4_14425 ENOG4107FQ9 ethanolamine ammonia-lyase EML4_14430 ENOG4107SUZ Sodium/hydrogen exchanger family EML4_14435 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) EML4_14450 ENOG4105CJP fad dependent oxidoreductase EML4_14455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_14465 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EML4_14470 ENOG4105MWK D-amino acid dehydrogenase, small subunit EML4_14485 ENOG4108JQ6 ABC transporter EML4_14495 ENOG4105BZU Histidine kinase EML4_14530 ENOG4105E0F Histidine kinase EML4_14535 ENOG4108ZHJ Organic hydroperoxide resistance protein EML4_14545 ENOG4105CIR epoxide hydrolase EML4_14570 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EML4_14580 ENOG4108ZXC Two component transcriptional regulator, luxr family EML4_14585 ENOG4108ZXC Two component transcriptional regulator, luxr family EML4_14605 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) EML4_14610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_14625 ENOG4108FUF Transcriptional regulator, IclR family EML4_14640 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EML4_14660 ENOG4105EW9 transcriptional regulator AsnC family EML4_14665 ENOG4107SCK Monooxygenase EML4_14685 ENOG4105C2W permease EML4_14695 ENOG4105ETT transcriptional Regulator, LysR family EML4_14740 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EML4_14745 ENOG4105F38 ABC transporter, permease EML4_14755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_14780 ENOG4107SDU Methyl-accepting chemotaxis EML4_14805 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EML4_14810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_14820 ENOG4105GVF (ABC) transporter EML4_14825 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EML4_14830 ENOG4108SNK aliphatic sulfonates import ATP-binding protein SsuB EML4_14835 ENOG4105DRS transport system, permease EML4_14840 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EML4_14870 ENOG4105ETE Transcriptional regulator (LacI family EML4_14885 ENOG4108WBH protein TIM barrel EML4_14900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_14905 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EML4_14910 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EML4_14915 ENOG4105BZ7 extracellular solute-binding protein family 1 EML4_14920 ENOG4108W9H Tetr family transcriptional regulator EML4_14940 ENOG4105DDC Oxidoreductase domain protein EML4_14960 ENOG4105K5G 30S ribosomal protein S21 EML4_14980 ENOG4105FAT Acyl-transferase EML4_14985 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EML4_14990 ENOG4107XII Glycosyl Hydrolase Family 88 EML4_15010 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EML4_15015 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component EML4_15025 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_15035 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EML4_15040 ENOG4105GAK amidohydrolase 2 EML4_15045 ENOG4105CXK mandelate racemase muconate lactonizing EML4_15050 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EML4_15055 ENOG4105CHR reductase EML4_15060 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) EML4_15065 ENOG4105E9Z Nad-dependent epimerase dehydratase EML4_15070 ENOG4105JXH GntR family transcriptional regulator EML4_15085 ENOG4105CPC Aldo Keto reductase EML4_15115 ENOG41063TF transcriptional regulator (AraC EML4_15120 ENOG4105EU0 Major facilitator Superfamily EML4_15125 ENOG4105W8I Transcriptional regulator EML4_15130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_15140 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EML4_15145 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EML4_15160 ENOG4105ETE Transcriptional regulator (LacI family EML4_15165 ENOG4105CPQ Dehydrogenase EML4_15170 ENOG4105CHR reductase EML4_15180 ENOG4107UEK pfkb domain protein EML4_15185 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of EML4_15200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_15210 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_15240 ENOG4105DSE periplasmic solute binding protein EML4_15245 ENOG4105CC5 ABC transporter EML4_15250 ENOG4105DIK (ABC) transporter EML4_15255 ENOG4105CKI cobalamin synthesis protein EML4_15270 ENOG4105CKI cobalamin synthesis protein EML4_15275 ENOG4108IJG ABC transporter substrate-binding protein EML4_15280 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EML4_15285 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EML4_15290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_15325 ENOG4105CC0 LysR family Transcriptional regulator EML4_15330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EML4_15335 ENOG4105CNN ABC, transporter EML4_15350 ENOG4105BZS acriflavin resistance protein EML4_15355 ENOG4105C1P efflux transporter, rnd family, mfp subunit EML4_15360 ENOG4105BZU Histidine kinase EML4_15365 ENOG4105S0E allantoin catabolism protein EML4_15380 ENOG4105DG4 malate L-lactate dehydrogenase EML4_15390 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_15415 ENOG4107STF Involved in phosphonate degradation (By similarity) EML4_15425 ENOG4108KB1 transcriptional regulator, arac family EML4_15430 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase EML4_15445 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EML4_15450 ENOG4105C2J ABC transporter EML4_15455 ENOG4107R9N ABC transporter EML4_15460 ENOG41062B0 ABC transporter, permease EML4_15465 ENOG4107EJG GntR family transcriptional regulator EML4_15480 ENOG4107SWE Methyltransferase EML4_15485 ENOG4105C0B DNA polymerase III (alpha subunit) EML4_15530 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_15540 ENOG4105XN3 extracellular solute-binding protein family 1 EML4_15550 ENOG4105EPC oxidoreductase EML4_15580 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EML4_15585 ENOG4107QMS site-determining protein EML4_15590 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EML4_15595 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 EML4_15600 ENOG4107YCY Transcriptional regulator EML4_15605 ENOG4108ERU trap dicarboxylate transporter subunit DctP EML4_15615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_15620 ENOG4105CPQ Dehydrogenase EML4_15625 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EML4_15645 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EML4_15650 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_15655 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EML4_15670 ENOG4105CYM Glutathione S-transferase EML4_15675 ENOG4108JQ6 ABC transporter EML4_15680 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) EML4_15695 ENOG41069H0 dihydroorotase EC 3.5.2.3 EML4_15710 ENOG4106R87 Extracellular solute-binding protein, family 5 EML4_15715 ENOG4105JNK Glycosyl transferase (Group 1 EML4_15755 ENOG4107QM2 Aldo Keto reductase EML4_15775 ENOG4108M8H domain protein EML4_15790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_15795 ENOG4107T3P ABC, transporter EML4_15800 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EML4_15810 ENOG4105CJQ hydrolase, family 31 EML4_15820 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component EML4_15825 ENOG4107Z6I Thiamine biosynthesis protein EML4_15830 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EML4_15835 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EML4_15850 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EML4_15855 ENOG4105MWK D-amino acid dehydrogenase, small subunit EML4_15880 ENOG4105CK2 sodium dicarboxylate symporter EML4_15890 ENOG4106PGW Short-chain dehydrogenase reductase Sdr EML4_15910 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) EML4_15920 ENOG4107QZ7 Cellulose synthase catalytic subunit EML4_15930 ENOG4107SZR mannose-6-phosphate isomerase EML4_15950 ENOG4105CMR udp-glucose 4-epimerase EML4_15955 ENOG4108IAJ Nad-dependent epimerase dehydratase EML4_15965 ENOG4105WH1 Two component transcriptional regulator luxr family EML4_15980 ENOG4108JJ6 Type I secretion system ATPase EML4_15985 ENOG4107QZV Type I secretion membrane fusion protein EML4_16015 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EML4_16025 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_16035 ENOG4105CHR reductase EML4_16045 ENOG4108VX5 3-methyladenine DNA glycosylase EML4_16060 ENOG4105FKQ transcriptional regulator EML4_16065 ENOG4107T3P ABC, transporter EML4_16080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_16090 ENOG4107RJ5 oxidoreductase EML4_16095 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EML4_16100 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EML4_16105 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EML4_16115 ENOG4105D9R oxidoreductase EML4_16130 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component EML4_16160 ENOG4106NZI LysR family Transcriptional regulator EML4_16165 ENOG4105C6K Malic enzyme EML4_16180 ENOG4105DRP amino acid AbC transporter EML4_16185 ENOG4105CDA abc transporter atp-binding protein EML4_16190 ENOG4108PGP mmge prpd family protein EML4_16200 ENOG4107SDU Methyl-accepting chemotaxis EML4_16205 ENOG4105MWK D-amino acid dehydrogenase, small subunit EML4_16220 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ EML4_16225 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_16230 ENOG4105CH5 extracellular solute-binding protein, family 7 EML4_16235 ENOG4108Z86 Glutamine amidotransferase EML4_16240 ENOG4105CNN ABC, transporter EML4_16245 ENOG4105C2J ABC transporter EML4_16260 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B EML4_16265 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_16280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_16290 ENOG4105GZI Transcriptional regulator EML4_16295 ENOG4105D44 asparaginase EML4_16310 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_16325 ENOG4108JQ6 ABC transporter EML4_16330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_16335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_16340 ENOG4108S01 response regulator EML4_16345 ENOG4105JSC dimethylmenaquinone methyltransferase EML4_16350 ENOG4105E9Z Nad-dependent epimerase dehydratase EML4_16365 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EML4_16370 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EML4_16380 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EML4_16385 ENOG4105D9R oxidoreductase EML4_16430 ENOG4108KPJ rna polymerase sigma factor EML4_16435 ENOG4105E0A ABC, transporter EML4_16440 ENOG4105EHG Permease protein EML4_16455 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EML4_16465 ENOG4105E0A ABC, transporter EML4_16470 ENOG4105EHG Permease protein EML4_16515 ENOG4105C26 Dehydrogenase EML4_16520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EML4_16525 ENOG4105C26 Dehydrogenase EML4_16530 ENOG4105CJP fad dependent oxidoreductase EML4_16545 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EML4_16565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_16570 ENOG4108JQ6 ABC transporter EML4_16575 ENOG4108RYR transcriptional regulator AsnC family EML4_16580 ENOG4105MWK D-amino acid dehydrogenase, small subunit EML4_16595 ENOG41065RR hydrogen cyanide synthase HcnA EML4_16600 ENOG4105RQF LysR family Transcriptional regulator EML4_16610 ENOG4105EAB amino acid AbC transporter EML4_16615 ENOG4105CDA abc transporter atp-binding protein EML4_16625 ENOG4105CH2 amidohydrolase EML4_16635 ENOG4105DEN Luciferase family EML4_16640 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family EML4_16650 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) EML4_16655 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EML4_16670 ENOG4105KHC sulfurtransferase EML4_16685 ENOG4105C1G acyl-Coa dehydrogenase EML4_16695 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_16720 ENOG4105CPC Aldo Keto reductase EML4_16730 ENOG4105ETT transcriptional Regulator, LysR family EML4_16740 ENOG4105E43 Extracellular solute-binding protein, family 5 EML4_16755 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_16760 ENOG4105CH2 amidohydrolase EML4_16765 ENOG4105FBW Monooxygenase EML4_16785 ENOG4108M8W Monooxygenase EML4_16790 ENOG4105DIA mandelate racemase muconate lactonizing EML4_16800 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_16805 ENOG4108JQ7 (ABC) transporter EML4_16810 ENOG4105C3U ABC transporter EML4_16820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_16830 ENOG4105JXH GntR family transcriptional regulator EML4_16845 ENOG4108UU4 oxidoreductase (Short chain dehydrogenase reductase family) EML4_16855 ENOG4107S76 domain protein EML4_16860 ENOG41080HT Transcriptional regulator, arsr family EML4_16870 ENOG4105KFG YeeE YedE family protein EML4_16875 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EML4_16880 ENOG4107QSN dihydrolipoamide acetyltransferase EML4_16885 ENOG4105CPP Dehydrogenase, E1 component EML4_16890 ENOG4107R0V Pyruvate dehydrogenase EML4_16895 ENOG4105C1G acyl-Coa dehydrogenase EML4_16900 ENOG4105CHU acetyl-coa acetyltransferase EML4_16905 ENOG4105J0Q Transcriptional regulator EML4_16910 ENOG4105C1G acyl-Coa dehydrogenase EML4_16915 ENOG4107QX3 carboxylase EML4_16925 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EML4_16935 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EML4_16940 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EML4_16945 ENOG4105C9F isomerase EML4_16955 ENOG4105E98 transcriptional regulator DeoR family EML4_16965 ENOG4105C2J ABC transporter EML4_16970 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EML4_16975 ENOG4105F5R ABC transporter EML4_16980 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) EML4_16995 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EML4_17015 ENOG4105F1N DNA alkylation repair EML4_17020 ENOG4108IJ6 ABC transporter EML4_17025 ENOG4105ECW sulfate abc transporter EML4_17030 ENOG4108I5D sulfate abc transporter EML4_17035 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein EML4_17040 ENOG4108IPT Naphthoate synthase EML4_17055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EML4_17070 ENOG4105VW4 glutaredoxin 3 EML4_17075 ENOG41081UC Inherit from COG: Competence protein EML4_17080 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EML4_17095 ENOG4105M6F mutator MutT protein EML4_17105 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EML4_17110 ENOG4105EIN peptidylprolyl cis-trans isomerase EML4_17115 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EML4_17120 ENOG4105FDR Membrane EML4_17230 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EML4_17235 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EML4_17250 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EML4_17275 ENOG4105EG2 ABC transporter, permease EML4_17330 ENOG4108WRK Transcriptional regulator EML4_17340 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EML4_17345 ENOG4105C2J ABC transporter EML4_17350 ENOG4108HWW ABC transporter EML4_17355 ENOG4105DFW ABC transporter EML4_17365 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EML4_17395 ENOG4105CYM Glutathione S-transferase EML4_17400 ENOG4107QX3 carboxylase EML4_17405 ENOG4105CFF transcriptional regulator EML4_17415 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EML4_17425 ENOG4105E1F short-chain dehydrogenase reductase EML4_17435 ENOG4108WBT adenosyltransferase EML4_17445 ENOG4105BZJ Electron transfer flavoprotein EML4_17450 ENOG4105C10 Electron transfer flavoprotein EML4_17455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EML4_17465 ENOG4107ZT5 Thiol disulfide interchange protein EML4_17470 ENOG4105CH7 arginosuccinase EML4_17480 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EML4_17495 ENOG4108UGV hypoxanthine phosphoribosyltransferase EML4_17505 ENOG4105CAK Cell division ATP-binding protein ftsE EML4_17525 ENOG4108NH8 Cation transport protein EML4_17540 ENOG4105CIH Imidazole acetol-phosphate transaminase EML4_17545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EML4_17550 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EML4_17570 ENOG4105KDC 50s ribosomal protein l28 EML4_17575 ENOG4105EX9 Membrane EML4_17615 ENOG4105D49 3-dehydroquinate synthase EML4_17620 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EML4_17630 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EML4_17635 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EML4_17640 ENOG4105F7V ErfK ybiS ycfS ynhG family protein EML4_17645 ENOG4105VFE sira family EML4_17650 ENOG4105CKI cobalamin synthesis protein EML4_17655 ENOG4105DZ1 carboxypeptidase EML4_17670 ENOG4108JQB penicillin-binding protein 1C EML4_17675 ENOG4105DN3 alpha-2-macroglobulin domain protein EML4_17680 ENOG4105W49 UPF0434 protein EML4_17690 ENOG4105K63 Thioredoxin EML4_17715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EML4_17730 ENOG4108JQ1 Dehydrogenase EML4_17745 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EML4_17750 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EML4_17755 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EML4_17765 ENOG4105KCK Peptidoglycan-associated lipoprotein EML4_17770 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EML4_17780 ENOG4105SG9 biopolymer transport protein, ExbD EML4_17785 ENOG4105E02 MotA TolQ exbB proton channel EML4_17790 ENOG4107YD3 Thioesterase EML4_17800 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EML4_17815 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EML4_17820 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EML4_17825 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EML4_17835 ENOG4105DEN Luciferase family EML4_17840 ENOG4105CDY transcriptional regulatory protein EML4_17855 ENOG4105D48 metallophosphoesterase EML4_17900 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) EML4_17905 ENOG4105BZA Phosphoglycerate kinase EML4_17910 ENOG4107R1Y fructose-bisphosphate aldolase EML4_17935 ENOG41082FS 50S ribosomal protein L31 EML4_17940 ENOG4105BZ1 (ABC) transporter EML4_17950 ENOG4105UYK outer membrane protein a EML4_17960 ENOG4105ECY inositol monophosphatase EML4_17995 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EML4_18005 ENOG4105M0T TPR Repeat-Containing Protein EML4_18010 ENOG4105Y2X UPF0335 protein EML4_18030 ENOG4105CA9 Pyruvate kinase EML4_18035 ENOG4105EAQ (twin-arginine translocation) pathway signal EML4_18040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EML4_18045 ENOG4105DPN Oligoendopeptidase f EML4_18050 ENOG4107Z5F Aminotransferase class IV EML4_18060 ENOG4105FE5 Homospermidine synthase EML4_18065 ENOG4105ZWB Outer membrane lipoprotein EML4_18070 ENOG4105CGH 5'-nucleotidase EML4_18075 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EML4_18080 ENOG4107QX8 SPFH domain, Band 7 family protein EML4_18090 ENOG4105C2X Arabinose 5-phosphate isomerase EML4_18115 ENOG4105CVE Lytic murein transglycosylase EML4_18130 ENOG4106F60 Histidine kinase EML4_18150 ENOG4105C5W Aldolase EML4_18160 ENOG4105C08 Histidine kinase EML4_18165 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EML4_18170 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EML4_18180 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EML4_18190 ENOG4105HDK L-asparaginase EML4_18200 ENOG4108IJ0 Aspartate ammonia-lyase EML4_18205 ENOG41073TP transcriptional regulator EML4_18210 ENOG4105BZS acriflavin resistance protein EML4_18220 ENOG4105C1P efflux transporter, rnd family, mfp subunit EML4_18225 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EML4_18230 ENOG4105CZE histidine utilization repressor EML4_18245 ENOG4108HQS Glycine betaine EML4_18250 ENOG4108IJ7 Glycine betaine EML4_18255 ENOG4105C84 Histidine ammonia-lyase EML4_18270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EML4_18275 ENOG4108JQ6 ABC transporter EML4_18280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_18290 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_18305 ENOG4105C0A alcohol dehydrogenase EML4_18325 ENOG4105NAU thioesterase Superfamily protein EML4_18345 ENOG4105NPQ Pfam:DUF403 EML4_18360 ENOG4105C5H ABC transporter EML4_18365 ENOG4105C5I Dehydrogenase EML4_18370 ENOG4105C6F GntR Family Transcriptional Regulator EML4_18390 ENOG4105DRS transport system, permease EML4_18395 ENOG4105EP8 Glycosyl Hydrolase Family 88 EML4_18400 ENOG4108IJ9 (ABC) transporter EML4_18440 ENOG4105CPQ Dehydrogenase EML4_18445 ENOG4105JSC dimethylmenaquinone methyltransferase EML4_18450 ENOG4107R0W ABC transporter EML4_18460 ENOG4105DRP amino acid AbC transporter EML4_18465 ENOG4105DRP amino acid AbC transporter EML4_18475 ENOG4105C5I Dehydrogenase EML4_18480 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EML4_18485 ENOG4105EXW epimerase dehydratase EML4_18500 ENOG4105JSC dimethylmenaquinone methyltransferase EML4_18505 ENOG4105JN3 extra-cytoplasmic solute receptor family protein EML4_18520 ENOG4105DFI Membrane EML4_18525 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EML4_18530 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EML4_18540 ENOG4105P4J Allophanate hydrolase, subunit 1 EML4_18545 ENOG4107R7A Allophanate hydrolase subunit 2 EML4_18550 ENOG4105E7W lamb ycsf family protein EML4_18555 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_18565 ENOG4108I5D sulfate abc transporter EML4_18590 ENOG4105C8Q Methyl-accepting chemotaxis EML4_18595 ENOG4105CMG Carbohydrate kinase EML4_18600 ENOG41061GT Aldolase EML4_18610 ENOG4108FN7 Aldo keto reductase EML4_18620 ENOG4105CNN ABC, transporter EML4_18625 ENOG4105C2J ABC transporter EML4_18665 ENOG4108ZNX Heat shock protein EML4_18670 ENOG4105DHU Bile acid EML4_18680 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EML4_18710 ENOG4108IJ9 (ABC) transporter EML4_18715 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EML4_18720 ENOG4105E98 transcriptional regulator DeoR family EML4_18725 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EML4_18740 ENOG4108IFG nitrite reductase, (NAD(P)H) EML4_18745 ENOG4105D7T ABC transporter EML4_18770 ENOG4105DRR Transcriptional regulator, GntR family EML4_18775 ENOG4105C5A transporter EML4_18780 ENOG4105E7W lamb ycsf family protein EML4_18785 ENOG4105CFM UPF0317 protein EML4_18790 ENOG4105P4J Allophanate hydrolase, subunit 1 EML4_18795 ENOG4108JIK carboxylase EML4_18800 ENOG4105E5K Alpha-amylase EML4_18805 ENOG4108Z4X TRANSCRIPTIONal EML4_18810 ENOG4105D05 Receptor EML4_18815 ENOG4107QYG anthranilate phosphoribosyltransferase EML4_18855 ENOG4105KME endoribonuclease L-psp EML4_18870 ENOG41090B9 response to stress EML4_18875 ENOG4105CGP Urocanate hydratase EML4_18885 ENOG4105C84 Histidine ammonia-lyase EML4_18890 ENOG4105CI2 imidazolone-5-propionate hydrolase EML4_18895 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EML4_18935 ENOG4108JQ5 ABC transporter EML4_18940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_18945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_18950 ENOG4108J59 Extracellular solute-binding protein, family 5 EML4_18955 ENOG4105DRS transport system, permease EML4_18970 ENOG4105Y49 secretion protein, HlyD family EML4_18990 ENOG4105R1U AraC Family Transcriptional Regulator EML4_18995 ENOG4108IND Tetr family transcriptional regulator EML4_19000 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EML4_19025 ENOG4108ZT1 Transcriptional regulator EML4_19030 ENOG4105F04 LysR family Transcriptional regulator EML4_19035 ENOG4105C7F AcnD-accessory protein PrpF EML4_19050 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EML4_19075 ENOG4105W8I Transcriptional regulator EML4_19080 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EML4_19095 ENOG4105EFZ amidohydrolase EML4_19115 ENOG4105CBN LysR family transcriptional regulator EML4_19120 ENOG4105C57 major facilitator superfamily EML4_19135 ENOG4105E3W Two component transcriptional regulator (Winged helix family EML4_19140 ENOG4108QIF Phosphoesterase, PA-phosphatase related EML4_19185 ENOG4105K5X acetyltransferase EML4_19190 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EML4_19195 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EML4_19200 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EML4_19205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EML4_19210 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EML4_19225 ENOG41066UZ arginase EC 3.5.3.1 EML4_19235 ENOG4105DFI Membrane EML4_19260 ENOG4105CSH Transporter EML4_19265 ENOG4105ECM Sensor protein basS pmrB EML4_19270 ENOG4105XJC Two component transcriptional regulator (Winged helix family EML4_19275 ENOG4105DIJ Phosphoethanolamine transferase EML4_19285 ENOG4106NZI LysR family Transcriptional regulator EML4_19290 ENOG4105E0K tonB-dependent siderophore receptor EML4_19300 ENOG4105S6R Iron-hydroxamate transporter permease subunit EML4_19305 ENOG4105E0A ABC, transporter EML4_19315 ENOG4105G9V cytochrome C EML4_19340 ENOG4105C2J ABC transporter EML4_19345 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EML4_19350 ENOG4105BZU Histidine kinase EML4_19355 ENOG4105WH1 Two component transcriptional regulator luxr family EML4_19375 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) EML4_19380 ENOG4105D3G Pseudouridine synthase EML4_19390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EML4_19395 ENOG4108IJ7 Glycine betaine EML4_19400 ENOG4108HQS Glycine betaine EML4_19420 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase EML4_19500 ENOG4105K5G 30S ribosomal protein S21 EML4_19505 ENOG4105DDR sarcosine oxidase (Beta subunit) EML4_19520 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EML4_19540 ENOG4108ESZ Glycogen debranching enzyme EML4_19545 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EML4_19550 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EML4_19555 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) EML4_19560 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) EML4_19565 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EML4_19580 ENOG4108UYU AsnC family transcriptional regulator EML4_19590 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EML4_19595 ENOG4105CHR reductase EML4_19600 ENOG4105CPQ Dehydrogenase EML4_19610 ENOG4108JJ9 ABC, transporter EML4_19615 ENOG4108JJ8 (ABC) transporter EML4_19620 ENOG4105C4M (Ubiquinol oxidase) subunit I EML4_19625 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EML4_19650 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EML4_19655 ENOG4108IYU L-aspartate oxidase EML4_19660 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EML4_19690 ENOG4105CAT Cytidine monophosphate kinase EML4_19695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EML4_19735 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_19740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_19745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_19750 ENOG4105C3U ABC transporter EML4_19755 ENOG4108JQ7 (ABC) transporter EML4_19760 ENOG4105DEI Mannitol dehydrogenase EML4_19770 ENOG4105DIA mandelate racemase muconate lactonizing EML4_19790 ENOG4105C0Z ABC transporter EML4_19795 ENOG4108IV0 ABC, transporter EML4_19800 ENOG4105C32 Amino acid ABC transporter (Permease) EML4_19805 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EML4_19820 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EML4_19840 ENOG4105DZG Dehydrogenase EML4_19845 ENOG4108Z9Z response to DNA damage stimulus EML4_19875 ENOG4108Z0Z intracellular protease Pfpi family EML4_19895 ENOG4105D7Z glutathione synthase EML4_19900 ENOG4105C1B dTDP-glucose 4-6-dehydratase EML4_19905 ENOG4105C6Y Udp-glucose 6-dehydrogenase EML4_19920 ENOG4105CHF Glutathione S-transferase EML4_19925 ENOG4105ETT transcriptional Regulator, LysR family EML4_19930 ENOG4105C26 Dehydrogenase EML4_19935 ENOG4105GVF (ABC) transporter EML4_19940 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EML4_19945 ENOG4105E2Y ABC, transporter EML4_19955 ENOG4105EW9 transcriptional regulator AsnC family EML4_19970 ENOG41074H6 response regulator EML4_19980 ENOG410903D sensor protein EML4_20005 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) EML4_20020 ENOG4105CFH Aspartokinase EML4_20025 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EML4_20030 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EML4_20035 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EML4_20045 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EML4_20050 ENOG4105E4C Lytic transglycosylase catalytic EML4_20090 ENOG4105X54 addiction module antidote protein EML4_20120 ENOG4105CMT Dihydroxyacetone kinase EML4_20125 ENOG4105F7P transcriptional regulator AsnC family EML4_20130 ENOG4105C28 cystathionine EML4_20145 ENOG4108UZX fmn reductase EML4_20155 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EML4_20165 ENOG4108JQ5 ABC transporter EML4_20170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_20190 ENOG4105CQB FAD linked oxidase domain protein EML4_20210 ENOG4108DBC nitroreductase EML4_20230 ENOG4105C5Q Transcriptional regulator EML4_20240 ENOG4107U9B transcriptional regulator EML4_20255 ENOG4105JAB phenazine biosynthesis protein, phzf family EML4_20270 ENOG4105CC0 LysR family Transcriptional regulator EML4_20280 ENOG4105JQN Transcriptional regulator EML4_20285 ENOG4105CHJ isochorismatase hydrolase EML4_20310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_20315 ENOG4105F38 ABC transporter, permease EML4_20320 ENOG4105D38 putrescine abc transporter EML4_20325 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A EML4_20335 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EML4_20350 ENOG4105E0A ABC, transporter EML4_20355 ENOG4108IHU transport system permease protein EML4_20360 ENOG4105DQ5 transport system permease protein EML4_20365 ENOG4108HUF Transporter EML4_20370 ENOG4107RBR Receptor EML4_20375 ENOG41090KN UPF0303 protein EML4_20380 ENOG4105ETE Transcriptional regulator (LacI family EML4_20390 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) EML4_20395 ENOG41060WC Enoyl-CoA hydratase EML4_20405 ENOG4108JP0 extracellular solute-binding protein family 1 EML4_20420 ENOG4108IJ9 (ABC) transporter EML4_20445 ENOG4105R2D cytochrome C EML4_20450 ENOG4105Z4T Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EML4_20455 ENOG4105BZ9 Cytochrome C oxidase, subunit I EML4_20460 ENOG4105CCU oxidase (Subunit III) EML4_20475 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I EML4_20490 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EML4_20500 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EML4_20520 ENOG4108IG5 Transcriptional regulator EML4_20535 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EML4_20550 ENOG4105CPQ Dehydrogenase EML4_20560 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EML4_20570 ENOG4105CNN ABC, transporter EML4_20580 ENOG4105EF1 ribulokinase EML4_20590 ENOG4105CSH Transporter EML4_20620 ENOG4105UYK outer membrane protein a EML4_20675 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EML4_20695 ENOG4105CS6 Rhs element vgr protein EML4_20715 ENOG4105BZU Histidine kinase EML4_20735 ENOG4105ETE Transcriptional regulator (LacI family EML4_20740 ENOG4105EE5 Membrane protein terC EML4_20760 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_20765 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component EML4_20770 ENOG4105BZ7 extracellular solute-binding protein family 1 EML4_20775 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EML4_20785 ENOG4105FKQ transcriptional regulator EML4_20800 ENOG4105CBN LysR family transcriptional regulator EML4_20810 ENOG410836F Transposase EML4_20815 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EML4_20820 ENOG4105C2J ABC transporter EML4_20825 ENOG4105CNN ABC, transporter EML4_20830 ENOG4105CNN ABC, transporter EML4_20835 ENOG4105ETE Transcriptional regulator (LacI family EML4_20905 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EML4_20915 ENOG4108VKQ nitriC oxide reductase EML4_20940 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EML4_20945 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EML4_20950 ENOG4105K78 MarR family Transcriptional regulator EML4_20985 ENOG4108IY8 ABC, transporter EML4_21010 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EML4_21030 ENOG4108TSE Transferase EML4_21035 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EML4_21040 ENOG4105WQI isochorismatase EML4_21045 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EML4_21050 ENOG4105E4F Isochorismate synthase EML4_21060 ENOG4105C0W non-ribosomal peptide synthetase EML4_21065 ENOG4105CEY Amp-dependent synthetase and ligase EML4_21075 ENOG4105Q26 Siderophore-interacting protein EML4_21085 ENOG4105EHG Permease protein EML4_21090 ENOG4105DQ5 transport system permease protein EML4_21095 ENOG4105E0A ABC, transporter EML4_21110 ENOG4107RBR Receptor EML4_21115 ENOG4105C1G acyl-Coa dehydrogenase EML4_21120 ENOG4105ETT transcriptional Regulator, LysR family EML4_21125 ENOG4105ETE Transcriptional regulator (LacI family EML4_21135 ENOG4105F38 ABC transporter, permease EML4_21145 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_21155 ENOG4105CPN adenine deaminase EML4_21160 ENOG4107RSM transcriptional regulator EML4_21165 ENOG4105D94 Major Facilitator Superfamily EML4_21170 ENOG4105CH2 amidohydrolase EML4_21180 ENOG4108IGT Dipeptidase EML4_21185 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_21190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_21195 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_21200 ENOG4105C3U ABC transporter EML4_21205 ENOG4108JQ7 (ABC) transporter EML4_21210 ENOG4108M0I Transcriptional regulator EML4_21215 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_21225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_21230 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EML4_21235 ENOG4107R7Y intracellular protease Pfpi family EML4_21245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_21255 ENOG4107QSI ABC, transporter EML4_21260 ENOG4105CH2 amidohydrolase EML4_21265 ENOG4108JQ6 ABC transporter EML4_21270 ENOG4105DKT Transcriptional regulator EML4_21290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_21295 ENOG4105CHR reductase EML4_21300 ENOG4105DEI Mannitol dehydrogenase EML4_21310 ENOG4105EF1 ribulokinase EML4_21335 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EML4_21345 ENOG4105DKT Transcriptional regulator EML4_21350 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EML4_21355 ENOG4107258 Transcriptional regulator EML4_21360 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EML4_21370 ENOG4105CC5 ABC transporter EML4_21375 ENOG4105CC5 ABC transporter EML4_21380 ENOG4105DIK (ABC) transporter EML4_21385 ENOG4105DSE periplasmic solute binding protein EML4_21395 ENOG4108SKZ Patatin-like phospholipase EML4_21400 ENOG4105CRK lysyL-tRNA synthetase EML4_21405 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EML4_21415 ENOG4105EE5 Membrane protein terC EML4_21420 ENOG4105J7D transcriptional regulator EML4_21445 ENOG4105CMG Carbohydrate kinase EML4_21450 ENOG4105C93 Xylose Isomerase EML4_21460 ENOG4108RCM Nitroreductase EML4_21465 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EML4_21470 ENOG4108UMI ABC transporter, permease EML4_21475 ENOG4105D01 (LipO)protein EML4_21480 ENOG4105BZU Histidine kinase EML4_21485 ENOG4105C72 UPF0176 protein EML4_21500 ENOG4108UHU Aldolase EML4_21520 ENOG4105D7X high-affinity nickel-transporter EML4_21550 ENOG4105CKI cobalamin synthesis protein EML4_21560 ENOG4107MII Sugar-specific transcriptional regulator TrmB EML4_21565 ENOG4105ETE Transcriptional regulator (LacI family EML4_21570 ENOG4105C5I Dehydrogenase EML4_21580 ENOG4105DH8 myo-inositol catabolism EML4_21590 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EML4_21595 ENOG4105EDK PfkB domain protein EML4_21605 ENOG4108IV0 ABC, transporter EML4_21610 ENOG4105C0Z ABC transporter EML4_21625 ENOG4105CAD extracellular ligand-binding receptor EML4_21640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_21650 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EML4_21655 ENOG4108JQ6 ABC transporter EML4_21680 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EML4_21685 ENOG4107S9B Shikimate dehydrogenase EML4_21690 ENOG4105CDA abc transporter atp-binding protein EML4_21695 ENOG4105CT1 (ABC) transporter EML4_21700 ENOG4105CT1 (ABC) transporter EML4_21705 ENOG4105E5Q amino acid AbC transporter EML4_21710 ENOG4105E5Q amino acid AbC transporter EML4_21715 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase EML4_21720 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha EML4_21725 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta EML4_21730 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase EML4_21740 ENOG4105DDW LysR family Transcriptional regulator EML4_21745 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EML4_21755 ENOG4107HP6 Transcriptional regulator EML4_21765 ENOG4107QNJ CoA-transferase subunit B EML4_21770 ENOG4105CHU acetyl-coa acetyltransferase EML4_21775 ENOG4105ETE Transcriptional regulator (LacI family EML4_21795 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) EML4_21805 ENOG4105ETE Transcriptional regulator (LacI family EML4_21810 ENOG4105DRS transport system, permease EML4_21820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_21830 ENOG4105F5H Glycosyl Hydrolase Family 88 EML4_21850 ENOG4105EYM Major Facilitator superfamily EML4_21855 ENOG4105E0K tonB-dependent siderophore receptor EML4_21860 ENOG4108S3W Anti-feci sigma factor, fecr EML4_21870 ENOG4105E2R ROK family EML4_21875 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EML4_21880 ENOG4108W6C Dehydrogenase EML4_21905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_21910 ENOG4108I5D sulfate abc transporter EML4_21925 ENOG4108Z4U Ferredoxin EML4_21930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EML4_21985 ENOG4105C09 Bile acid EML4_21990 ENOG4105CPC Aldo Keto reductase EML4_21995 ENOG4105HEI LysR family (Transcriptional regulator EML4_22105 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein EML4_22110 ENOG4108KQJ Type 11 methyltransferase EML4_22150 ENOG4105C4R Atp-dependent dna helicase EML4_22160 ENOG4105ETE Transcriptional regulator (LacI family EML4_22165 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EML4_22180 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component EML4_22195 ENOG4108JQ7 (ABC) transporter EML4_22205 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_22210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_22215 ENOG4107YCY Transcriptional regulator EML4_22235 ENOG4105BZU Histidine kinase EML4_22240 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EML4_22250 ENOG4105FDF Could be involved in DNA repair (By similarity) EML4_22255 ENOG4105DQE DNA ligase EML4_22260 ENOG4105FDF Could be involved in DNA repair (By similarity) EML4_22265 ENOG4107QXV Phosphate transporter EML4_22270 ENOG4107GRR phosphate transport regulator EML4_22295 ENOG4106F60 Histidine kinase EML4_22310 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) EML4_22325 ENOG4105E0K tonB-dependent siderophore receptor EML4_22335 ENOG4105DQ5 transport system permease protein EML4_22340 ENOG4105TVJ transport system, permease EML4_22345 ENOG4105E0A ABC, transporter EML4_22350 ENOG4105DND Transcriptional regulator EML4_22360 ENOG4105CBG Sulfatase EML4_22365 ENOG4107SS6 2-dehydro-3-deoxygluconokinase EML4_22375 ENOG4106IQC argininosuccinate lyase EML4_22380 ENOG4105DRS transport system, permease EML4_22390 ENOG4107FKK extracellular solute-binding protein family 1 EML4_22395 ENOG4107TFG D-allose kinase EML4_22435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_22440 ENOG4108JQ5 ABC transporter EML4_22445 ENOG4105F8D glycoside hydrolase family 4 EML4_22450 ENOG4105D0S secretion protein (HlyD EML4_22455 ENOG4105CJ1 ABC, transporter EML4_22460 ENOG4105CMI transporter EML4_22475 ENOG41074H6 response regulator EML4_22480 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EML4_22490 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EML4_22495 ENOG4105DG4 malate L-lactate dehydrogenase EML4_22510 ENOG4105E5Q amino acid AbC transporter EML4_22515 ENOG4105E5Q amino acid AbC transporter EML4_22535 ENOG4105CTU Proline racemase EML4_22540 ENOG4105ETE Transcriptional regulator (LacI family EML4_22550 ENOG4105E89 ABC transporter EML4_22555 ENOG4105E5Q amino acid AbC transporter EML4_22560 ENOG4105EAD ABC transporter EML4_22570 ENOG4105C5I Dehydrogenase EML4_22575 ENOG4105BZU Histidine kinase EML4_22590 ENOG4107QIZ NADH dehydrogenase EML4_22595 ENOG4108JB9 formate dehydrogenase EML4_22610 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EML4_22620 ENOG41073TP transcriptional regulator EML4_22630 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_22635 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_22640 ENOG4108JQ6 ABC transporter EML4_22645 ENOG4105CXK mandelate racemase muconate lactonizing EML4_22655 ENOG4108QBF Transcriptional regulator EML4_22660 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_22670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_22675 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EML4_22680 ENOG4108JQ6 ABC transporter EML4_22685 ENOG4105ECY inositol monophosphatase EML4_22695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_22720 ENOG4105VDW Csbd family EML4_22730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EML4_22740 ENOG4105BZ1 (ABC) transporter EML4_22770 ENOG4107QIJ Aconitate hydratase 2 EML4_22775 ENOG4105EQK -acetyltransferase EML4_22790 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EML4_22810 ENOG4105C2J ABC transporter EML4_22815 ENOG4105CNN ABC, transporter EML4_22820 ENOG4105F5R ABC transporter EML4_22830 ENOG4105DBI uridine monophosphokinase EML4_22835 ENOG4107TTA Xylose isomerase domain protein TIM barrel EML4_22865 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase EML4_22870 ENOG4105ENR peptidase, M24 EML4_22895 ENOG4105C26 Dehydrogenase EML4_22940 ENOG4105F4E fad dependent oxidoreductase EML4_22945 ENOG4105DTQ mandelate racemase muconate lactonizing EML4_22950 ENOG4105CDA abc transporter atp-binding protein EML4_22955 ENOG4105E5Q amino acid AbC transporter EML4_22965 ENOG4105ETT transcriptional Regulator, LysR family EML4_22970 ENOG4105CPT Alpha beta hydrolase EML4_22990 ENOG4105CQ0 ABC transporter EML4_23000 ENOG4105Q95 Cupin 2, conserved barrel domain protein EML4_23025 ENOG4105NPE arsR family transcriptional regulator EML4_23115 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EML4_23120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EML4_23145 ENOG4105E1F short-chain dehydrogenase reductase EML4_23155 ENOG4105EQR Transposase IS116 IS110 IS902 EML4_23170 ENOG4105EQX glucarate dehydratase EML4_23180 ENOG4105C5I Dehydrogenase EML4_23190 ENOG4105CHR reductase EML4_23200 ENOG4105E0S extracellular solute-binding protein family 1 EML4_23205 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EML4_23215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_23220 ENOG4107XBN GntR Family Transcriptional Regulator EML4_23235 ENOG4105H1G trap transporter solute receptor taxi family EML4_23250 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_23265 ENOG4107S1E Beta-lactamase EML4_23275 ENOG4106TD9 Diguanylate cyclase EML4_23310 ENOG4105CHR reductase EML4_23320 ENOG4105D8X mechanosensitive ion channel EML4_23355 ENOG4107RTG Major Facilitator superfamily EML4_23390 ENOG4105K5G 30S ribosomal protein S21 EML4_23465 ENOG4105D74 hydrolase EML4_23535 ENOG4108C33 Resolvase EML4_23580 ENOG4105CDA abc transporter atp-binding protein EML4_23585 ENOG4106TNF Periplasmic binding protein EML4_23590 ENOG4105ETE Transcriptional regulator (LacI family EML4_23640 ENOG4105ENA helicase EML4_23770 ENOG4107XZA Glycosyl transferase family 2 EML4_23795 ENOG4108VB1 regulatoR EML4_23805 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) EML4_23830 ENOG4105CPI Metal Dependent Phosphohydrolase EML4_23845 ENOG4105CMG Carbohydrate kinase EML4_23865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EML4_23875 ENOG4107RHR regulatoR EML4_23960 ENOG4105EXG Transcriptional regulator EML4_23965 ENOG4105CHR reductase EML4_23970 ENOG4105KVH Transcriptional regulator EML4_23975 ENOG4105CHR reductase EML4_23985 ENOG4105KVH Transcriptional regulator EML4_23990 ENOG4105KVH Transcriptional regulator EML4_24020 ENOG4105DQE DNA ligase EML4_24035 ENOG4105E5W Transporter EML4_24040 ENOG4105DJ2 Major Facilitator Superfamily EML4_24045 ENOG4108ZT1 Transcriptional regulator EML4_24060 ENOG4105C2C drug resistance transporter, Bcr CflA EML4_24075 ENOG4105F7P transcriptional regulator AsnC family EML4_24150 ENOG4105E2R ROK family EML4_24155 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator EML4_24160 ENOG4105CNN ABC, transporter EML4_24165 ENOG4105C2J ABC transporter EML4_24170 ENOG4105EF1 ribulokinase EML4_24175 ENOG4105E98 transcriptional regulator DeoR family EML4_24180 ENOG4105CHR reductase EML4_24215 ENOG4108R85 Short chain dehydrogenase EML4_24230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EML4_24270 ENOG410642W LysR family Transcriptional regulator EML4_24280 ENOG4105CHR reductase EML4_24285 ENOG4105K56 Transcriptional regulator EML4_24295 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EML4_24300 ENOG4105VGJ Virulence-associated protein EML4_24305 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A EML4_24315 ENOG410829K Lysine exporter protein (Lyse ygga) EML4_24325 ENOG4108XFH Transcriptional regulator EML4_24335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EML4_24340 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EML4_24350 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) EML4_24355 ENOG4105CPC Aldo Keto reductase EML4_24365 ENOG4105D3W isochorismatase EML4_24375 ENOG4105CHR reductase EML4_24380 ENOG4105CF7 AraC family transcriptional regulator EML4_24395 ENOG4105CBN LysR family transcriptional regulator EML4_24405 ENOG4108IXY short-chain dehydrogenase reductase EML4_24420 ENOG4105BZW Glycerate kinase EML4_24475 ENOG4107QM5 aconitate hydratase EML4_24480 ENOG4105S6R Iron-hydroxamate transporter permease subunit EML4_24500 ENOG4105EMN RNA polymerase sigma factor EML4_24505 ENOG4105EQ2 LysR family Transcriptional regulator EML4_24520 ENOG4105E7U AraC family transcriptional regulator EML4_24530 ENOG4105EMU Dehydrogenase EML4_24550 ENOG4105EMU Dehydrogenase EML4_24555 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EML4_24565 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EML4_24575 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EML4_24590 ENOG4105EUB pirin domain protein EML4_24595 ENOG4105EQ1 Transcriptional regulator EML4_24615 ENOG4105WH1 Two component transcriptional regulator luxr family EML4_24620 ENOG4105ENE Histidine kinase EML4_24635 ENOG4105CS1 NAD(P)H quinone oxidoreductase EML4_24645 ENOG4105VSH 4-oxalocrotonate tautomerase EML4_24660 ENOG4108A65 Transcriptional regulator EML4_24675 ENOG4105D6J arsenicaL-resistance protein EML4_24720 ENOG4108Z9Z response to DNA damage stimulus EML4_24775 ENOG4108UN4 phage SPO1 DNA polymerase-related protein EML4_24830 ENOG4105HEI LysR family (Transcriptional regulator EML4_24850 ENOG4108IMY Transcriptional regulator EML4_24855 ENOG4108Z7F N-acetyltransferase EML4_24865 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EML4_24885 ENOG4105CH5 extracellular solute-binding protein, family 7 EML4_24890 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EML4_24905 ENOG4108ZNX Heat shock protein EML4_24920 ENOG4107R3N Filamentation induced by cAMP protein fic EML4_24930 ENOG4105F9F transposase EML4_24935 ENOG4107YBY Hydrolase EML4_24965 ENOG4105D7N magnesium and cobalt transport protein CorA EML4_24970 ENOG4105CKW Inner membrane protein yedI EML4_24995 ENOG410903D sensor protein EML4_25005 ENOG4105C7B Threonine dehydratase EML4_25010 ENOG4105CHR reductase EML4_25015 ENOG4108FUF Transcriptional regulator, IclR family EML4_25020 ENOG4105CMR udp-glucose 4-epimerase EML4_25025 ENOG4108IJ9 (ABC) transporter EML4_25030 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EML4_25035 ENOG4105D56 permease protein EML4_25045 ENOG4105CXK mandelate racemase muconate lactonizing EML4_25050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EML4_25055 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EML4_25085 ENOG4107QN2 dihydrolipoyl dehydrogenase EML4_25100 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) EML4_25105 ENOG4105BZ9 Cytochrome C oxidase, subunit I EML4_25145 ENOG4105K2J Transcriptional regulator EML4_25150 ENOG4105DIA mandelate racemase muconate lactonizing EML4_25155 ENOG4107RSM transcriptional regulator EML4_25195 ENOG4105E80 TraG TraD family protein EML4_25205 ENOG4105K70 DNA-binding protein EML4_25215 ENOG4108EHY type IV secretion system EML4_25220 ENOG4105CMA conjugation trbi family protein EML4_25230 ENOG4108V42 Type IV secretion system protein VirB8 EML4_25295 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EML4_25345 ENOG4108JGH Tetr family transcriptional regulator EML4_25360 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EML4_25365 ENOG4105DHQ Histidine kinase EML4_25370 ENOG4105XJC Two component transcriptional regulator (Winged helix family EML4_25375 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EML4_25380 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EML4_25385 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase EML4_25415 ENOG4105JSC dimethylmenaquinone methyltransferase EML4_25430 ENOG4108JQ6 ABC transporter EML4_25435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_25445 ENOG4106R87 Extracellular solute-binding protein, family 5 EML4_25450 ENOG4108RYR transcriptional regulator AsnC family EML4_25455 ENOG4105C26 Dehydrogenase EML4_25460 ENOG4105C8Y Acetylornithine aminotransferase EML4_25480 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions EML4_25510 ENOG4105S66 prophage protein EML4_25525 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase EML4_25545 ENOG4105CT1 (ABC) transporter EML4_25550 ENOG4105E5Q amino acid AbC transporter EML4_25560 ENOG4105CDA abc transporter atp-binding protein EML4_25570 ENOG4105JXH GntR family transcriptional regulator EML4_25585 ENOG4105CXK mandelate racemase muconate lactonizing EML4_25595 ENOG4105DRR Transcriptional regulator, GntR family EML4_25605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_25610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_25625 ENOG4107S5I aldo keto reductase EML4_25630 ENOG4105EQ2 LysR family Transcriptional regulator EML4_25670 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EML4_25690 ENOG4106PMH Extracellular solute-binding protein family 3 EML4_25755 ENOG4105K56 Transcriptional regulator EML4_25765 ENOG4105EQR Transposase IS116 IS110 IS902 EML4_25770 ENOG4105EQR Transposase IS116 IS110 IS902 EML4_25810 ENOG4105BZU Histidine kinase EML4_25860 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EML4_25865 ENOG4108R85 Short chain dehydrogenase EML4_25875 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EML4_25880 ENOG4105CNN ABC, transporter EML4_25885 ENOG4108HHA Transketolase EML4_25890 ENOG4108IUS Transketolase EML4_25895 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EML4_25900 ENOG4107RHR regulatoR EML4_25910 ENOG4105ECQ AraC Family Transcriptional Regulator EML4_25920 ENOG4108Z0R Transferase EML4_25960 ENOG4105BZU Histidine kinase EML4_25995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EML4_26000 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EML4_26010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_26015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EML4_26030 ENOG4107KJX Transcriptional regulator EML4_26035 ENOG4105ECK Fatty Acid Desaturase EML4_26040 ENOG4105BZU Histidine kinase EML4_26070 ENOG4105BZU Histidine kinase EML4_26090 ENOG4105DJY efflux transporter, rnd family, mfp subunit EML4_26095 ENOG4105BZU Histidine kinase EML4_26100 ENOG4105XJC Two component transcriptional regulator (Winged helix family EML4_26155 ENOG4105EJC lysr family transcriptional regulator EML4_26175 ENOG4105HEI LysR family (Transcriptional regulator EML4_26250 ENOG4105ETT transcriptional Regulator, LysR family EML4_26260 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EML4_26265 ENOG4105D7T ABC transporter EML4_26270 ENOG4107Z6I Thiamine biosynthesis protein EML4_26285 ENOG4105CHR reductase EML4_26315 ENOG4105CNN ABC, transporter EML4_26320 ENOG4105C2J ABC transporter EML4_26345 ENOG4108JQ6 ABC transporter EML4_26350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_26365 ENOG4105CPU Monooxygenase EML4_26375 ENOG4105CBN LysR family transcriptional regulator EML4_26400 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EML4_26405 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EML4_26425 ENOG4105DQE DNA ligase EML4_26485 ENOG4105FA0 parb-like partition protein EML4_26505 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EML4_26550 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EML4_26570 ENOG4105K70 DNA-binding protein EML4_26630 ENOG4107SDU Methyl-accepting chemotaxis EML4_26650 ENOG4105EAM Na Pi-cotransporter EML4_26665 ENOG4105DEF Extracellular solute-binding protein, family 5 EML4_26670 ENOG4105C3U ABC transporter EML4_26685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EML4_26690 ENOG4107T6V glycerophosphoryl diester phosphodiesterase EML4_26695 ENOG4105ECY inositol monophosphatase EML4_27030 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) EML4_27040 ENOG4107RSM transcriptional regulator