locus-tag	class	description
I6I05_00010	COG0583	DNA-binding transcription factor activity
I6I05_00030	COG5002	protein histidine kinase activity
I6I05_00035	COG1404	Belongs to the peptidase S8 family
I6I05_00065	COG1929	Belongs to the glycerate kinase type-1 family
I6I05_00100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_00105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I05_00120	COG0583	DNA-binding transcription factor activity
I6I05_00130	COG0583	DNA-binding transcription factor activity
I6I05_00135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I05_00150	COG0583	DNA-binding transcription factor activity
I6I05_00155	COG3547	Transposase (IS116 IS110 IS902 family)
I6I05_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_00170	COG0842	Transport permease protein
I6I05_00170	COG1129	ABC transporter
I6I05_00175	COG0842	Transport permease protein
I6I05_00180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I05_00185	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I6I05_00210	COG0668	transmembrane transport
I6I05_00215	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_00225	COG0583	DNA-binding transcription factor activity
I6I05_00245	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_00280	COG0517	IMP dehydrogenase activity
I6I05_00280	COG4175	Glycine betaine
I6I05_00285	COG4176	ABC-type proline glycine betaine transport system permease component
I6I05_00295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I05_00305	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I05_00325	COG1414	Transcriptional regulator
I6I05_00330	COG0410	ABC transporter
I6I05_00400	COG0531	amino acid
I6I05_00430	COG1129	ABC transporter
I6I05_00435	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_00440	COG1879	ABC-type sugar transport system periplasmic component
I6I05_00445	COG0673	inositol 2-dehydrogenase activity
I6I05_00450	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_00460	COG3962	Belongs to the TPP enzyme family
I6I05_00465	COG3718	enzyme involved in inositol metabolism
I6I05_00470	COG1942	4-Oxalocrotonate Tautomerase
I6I05_00495	COG1132	(ABC) transporter
I6I05_00520	COG0747	negative chemotaxis
I6I05_00525	COG0601	transmembrane transport
I6I05_00535	COG4172	Belongs to the ABC transporter superfamily
I6I05_00540	COG1349	DNA-binding transcription factor activity
I6I05_00545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I05_00580	COG2207	Transcriptional regulator
I6I05_00595	COG1566	PFAM secretion protein HlyD family protein
I6I05_00610	COG0668	transmembrane transport
I6I05_00665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I05_00670	COG1280	lysine exporter protein (LysE YggA)
I6I05_00680	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_00700	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_00705	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_00710	COG1129	ABC transporter
I6I05_00715	COG1879	ABC-type sugar transport system periplasmic component
I6I05_00720	COG1349	DNA-binding transcription factor activity
I6I05_00730	COG1120	ATPase activity
I6I05_00735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_00740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_00750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I05_00755	COG4774	siderophore transport
I6I05_00770	COG0583	DNA-binding transcription factor activity
I6I05_00775	COG0667	Aldo Keto reductase
I6I05_00805	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_00840	COG1278	Cold shock
I6I05_00850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I05_00855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_00870	COG1538	Outer membrane efflux protein
I6I05_00885	COG1126	abc transporter atp-binding protein
I6I05_00890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_00895	COG1609	Transcriptional regulator
I6I05_00900	COG1192	Involved in chromosome partitioning
I6I05_00905	COG1475	DNA binding
I6I05_00910	COG0640	Transcriptional regulator
I6I05_00915	COG3077	Addiction module antitoxin, RelB DinJ family
I6I05_00945	COG3971	2-oxopent-4-enoate hydratase activity
I6I05_00950	COG3485	protocatechuate 3,4-dioxygenase
I6I05_01070	COG3620	sequence-specific DNA binding
I6I05_01075	COG3550	peptidyl-serine autophosphorylation
I6I05_01085	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01115	COG2072	flavoprotein involved in K transport
I6I05_01125	COG2144	transferase activity, transferring acyl groups
I6I05_01135	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I05_01150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I05_01165	COG1309	transcriptional regulator
I6I05_01170	COG1794	racemase activity, acting on amino acids and derivatives
I6I05_01180	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_01200	COG1116	anion transmembrane transporter activity
I6I05_01240	COG4221	oxidoreductase activity
I6I05_01285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01295	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01310	COG1741	Belongs to the pirin family
I6I05_01315	COG0583	DNA-binding transcription factor activity
I6I05_01335	COG0583	DNA-binding transcription factor activity
I6I05_01345	COG0235	Class ii aldolase
I6I05_01350	COG0583	DNA-binding transcription factor activity
I6I05_01355	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I05_01400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I05_01415	COG0667	Aldo Keto reductase
I6I05_01460	COG1802	Transcriptional regulator
I6I05_01485	COG3547	Transposase (IS116 IS110 IS902 family)
I6I05_01490	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I05_01510	COG3609	addiction module antidote protein, CC2985 family
I6I05_01560	COG3177	Filamentation induced by cAMP protein fic
I6I05_01610	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01620	COG0583	DNA-binding transcription factor activity
I6I05_01625	COG3842	ATPase activity
I6I05_01635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_01645	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_01650	COG4208	sulfate ABC transporter
I6I05_01675	COG1764	response to oxidative stress
I6I05_01715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_01730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I05_01735	COG1653	transport
I6I05_01740	COG1175	transmembrane transport
I6I05_01755	COG3842	ATPase activity
I6I05_01765	COG0583	DNA-binding transcription factor activity
I6I05_01790	COG1846	Transcriptional regulator
I6I05_01800	COG1335	isochorismatase
I6I05_01810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_01815	COG2207	Transcriptional regulator
I6I05_01825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I05_01835	COG3842	ATPase activity
I6I05_01840	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_01845	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_01865	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I05_01880	COG1228	amidohydrolase
I6I05_01900	COG0840	transmembrane signaling receptor activity
I6I05_01915	COG4691	Plasmid stability protein
I6I05_01920	COG1487	ribonuclease activity
I6I05_01925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_01935	COG2186	Transcriptional regulator
I6I05_01940	COG0747	negative chemotaxis
I6I05_01945	COG0601	transmembrane transport
I6I05_01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_01955	COG4172	Belongs to the ABC transporter superfamily
I6I05_01960	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_02000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_02015	COG0598	Magnesium transport protein CorA
I6I05_02020	COG1597	lipid kinase activity
I6I05_02025	COG2354	Protein conserved in bacteria
I6I05_02045	COG0577	efflux transmembrane transporter activity
I6I05_02055	COG1414	Transcriptional regulator
I6I05_02065	COG1454	alcohol dehydrogenase
I6I05_02085	COG0454	-acetyltransferase
I6I05_02085	COG0456	acetyltransferase
I6I05_02095	COG3436	PFAM IS66 Orf2 family protein
I6I05_02100	COG4372	Transposase
I6I05_02150	COG0784	Response regulator, receiver
I6I05_02150	COG4191	Histidine kinase
I6I05_02160	COG3547	Transposase (IS116 IS110 IS902 family)
I6I05_02175	COG1120	ATPase activity
I6I05_02180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_02185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_02190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I05_02195	COG4774	siderophore transport
I6I05_02195	COG1629	transport
I6I05_02205	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6I05_02215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I05_02250	COG2226	methyltransferase
I6I05_02260	COG0318	PFAM AMP-dependent synthetase and ligase
I6I05_02280	COG0534	Mate efflux family protein
I6I05_02290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I05_02310	COG3734	2-keto-3-deoxy-galactonokinase
I6I05_02315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_02320	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_02330	COG1175	transmembrane transport
I6I05_02335	COG0395	ABC-type sugar transport system, permease component
I6I05_02340	COG3842	ATPase activity
I6I05_02350	COG1414	Transcriptional regulator
I6I05_02355	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_02360	COG2207	Transcriptional regulator
I6I05_02370	COG0583	DNA-binding transcription factor activity
I6I05_02375	COG0667	Aldo Keto reductase
I6I05_02380	COG0583	DNA-binding transcription factor activity
I6I05_02390	COG1609	Transcriptional regulator
I6I05_02395	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_02400	COG0673	inositol 2-dehydrogenase activity
I6I05_02405	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_02415	COG0405	Gamma-glutamyltransferase
I6I05_02420	COG1120	ATPase activity
I6I05_02435	COG4774	siderophore transport
I6I05_02460	COG1215	transferase activity, transferring glycosyl groups
I6I05_02490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I05_02505	COG2390	Transcriptional regulator
I6I05_02510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I05_02515	COG3958	Transketolase
I6I05_02520	COG3959	Transketolase, thiamine diphosphate binding domain
I6I05_02525	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_02535	COG1129	ABC transporter
I6I05_02540	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_02545	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I05_02555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I05_02575	COG0477	Major facilitator Superfamily
I6I05_02595	COG1126	abc transporter atp-binding protein
I6I05_02600	COG0765	amino acid transport
I6I05_02605	COG0765	amino acid transport
I6I05_02610	COG1741	Belongs to the pirin family
I6I05_02615	COG1335	isochorismatase
I6I05_02625	COG1733	regulation of RNA biosynthetic process
I6I05_02630	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_02630	COG0604	alcohol dehydrogenase
I6I05_02630	COG3321	synthase
I6I05_02635	COG0583	DNA-binding transcription factor activity
I6I05_02655	COG1017	nitric oxide dioxygenase activity
I6I05_02655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I05_02660	COG0625	glutathione transferase activity
I6I05_02670	COG0583	DNA-binding transcription factor activity
I6I05_02685	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
I6I05_02690	COG3920	Histidine kinase
I6I05_02690	COG2202	Pas domain
I6I05_02755	COG1285	pathogenesis
I6I05_02775	COG4166	transmembrane transport
I6I05_02780	COG0601	transmembrane transport
I6I05_02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_02795	COG2843	Capsule synthesis protein
I6I05_02800	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I05_02815	COG4962	Type ii secretion system protein e
I6I05_02830	COG3451	type IV secretory pathway VirB4
I6I05_02835	COG5314	conjugation
I6I05_02845	COG3846	protein secretion by the type IV secretion system
I6I05_02850	COG3701	Conjugal transfer protein
I6I05_02880	COG1902	pentaerythritol trinitrate reductase activity
I6I05_02885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_02910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I05_02915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I05_02930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_02955	COG0667	Aldo Keto reductase
I6I05_02970	COG0673	inositol 2-dehydrogenase activity
I6I05_02980	COG0395	ABC-type sugar transport system, permease component
I6I05_02985	COG1175	transmembrane transport
I6I05_02990	COG3842	ATPase activity
I6I05_03010	COG3547	Transposase (IS116 IS110 IS902 family)
I6I05_03030	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_03040	COG1879	ABC-type sugar transport system periplasmic component
I6I05_03045	COG1879	ABC-type sugar transport system periplasmic component
I6I05_03050	COG0246	Mannitol dehydrogenase
I6I05_03060	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_03065	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_03075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I05_03090	COG1609	Transcriptional regulator
I6I05_03095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I05_03125	COG1070	Carbohydrate kinase
I6I05_03135	COG1175	transmembrane transport
I6I05_03140	COG0395	ABC-type sugar transport system, permease component
I6I05_03155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I05_03165	COG0596	Alpha beta hydrolase
I6I05_03165	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I05_03190	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_03205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_03240	COG3436	PFAM IS66 Orf2 family protein
I6I05_03245	COG4372	Transposase
I6I05_03250	COG0183	Belongs to the thiolase family
I6I05_03255	COG1024	Enoyl-CoA hydratase
I6I05_03265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I05_03275	COG0477	Major facilitator Superfamily
I6I05_03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_03290	COG1902	pentaerythritol trinitrate reductase activity
I6I05_03310	COG1621	beta-fructofuranosidase activity
I6I05_03330	COG0395	ABC-type sugar transport system, permease component
I6I05_03335	COG1175	transmembrane transport
I6I05_03340	COG1653	transport
I6I05_03345	COG1609	Transcriptional regulator
I6I05_03350	COG2801	Transposase and inactivated derivatives
I6I05_03365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I05_03390	COG2207	Transcriptional regulator
I6I05_03400	COG0840	transmembrane signaling receptor activity
I6I05_03410	COG4607	ABC-type enterochelin transport system periplasmic component
I6I05_03415	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_03420	COG4605	iron ion homeostasis
I6I05_03425	COG4604	ABC transporter, ATP-binding protein
I6I05_03490	COG3831	ATPase activity
I6I05_03495	COG5489	Protein of unknown function (DUF736)
I6I05_03515	COG1475	DNA binding
I6I05_03560	COG0587	DNA-directed DNA polymerase activity
I6I05_03585	COG1522	sequence-specific DNA binding
I6I05_03605	COG1846	Transcriptional regulator
I6I05_03610	COG2807	transmembrane transport
I6I05_03615	COG2211	Major facilitator Superfamily
I6I05_03630	COG0583	DNA-binding transcription factor activity
I6I05_03635	COG1309	transcriptional regulator
I6I05_03645	COG2020	methyltransferase activity
I6I05_03650	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_03660	COG1802	Transcriptional regulator
I6I05_03665	COG0747	negative chemotaxis
I6I05_03670	COG0601	transmembrane transport
I6I05_03675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_03685	COG4608	Belongs to the ABC transporter superfamily
I6I05_03705	COG1609	Transcriptional regulator
I6I05_03715	COG2084	Dehydrogenase
I6I05_03720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_03725	COG0277	FAD linked oxidase domain protein
I6I05_03730	COG2186	Transcriptional regulator
I6I05_03740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I05_03745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I05_03750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_03755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I05_03770	COG0495	leucyl-tRNA aminoacylation
I6I05_03785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I05_03790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I05_03800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I05_03805	COG1946	Acyl-CoA thioesterase
I6I05_03810	COG0347	Belongs to the P(II) protein family
I6I05_03815	COG0004	ammonium transporteR
I6I05_03820	COG1674	ftsk spoiiie
I6I05_03825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I05_03840	COG0745	RESPONSE REGULATOR receiver
I6I05_03850	COG1329	Transcriptional regulator
I6I05_03855	COG2902	Dehydrogenase
I6I05_03860	COG2270	Major facilitator Superfamily
I6I05_03875	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_03890	COG0494	nUDIX hydrolase
I6I05_03900	COG0793	Belongs to the peptidase S41A family
I6I05_03910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I05_03915	COG0799	negative regulation of ribosome biogenesis
I6I05_03920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I05_03925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I05_03930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I05_03935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I05_03950	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I05_03955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I05_03980	COG0066	3-isopropylmalate dehydratase activity
I6I05_03985	COG0473	3-isopropylmalate dehydrogenase activity
I6I05_03990	COG1858	cytochrome C peroxidase
I6I05_03995	COG1797	cobyrinic acid a,c-diamide synthase activity
I6I05_04000	COG1648	precorrin-2 dehydrogenase activity
I6I05_04000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I05_04005	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
I6I05_04070	COG1492	cobalamin metabolic process
I6I05_04075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6I05_04085	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_04090	COG3254	rhamnose metabolic process
I6I05_04095	COG0246	Mannitol dehydrogenase
I6I05_04100	COG1063	alcohol dehydrogenase
I6I05_04120	COG4214	carbohydrate transport
I6I05_04125	COG1129	ABC transporter
I6I05_04130	COG2186	Transcriptional regulator
I6I05_04135	COG2721	sulfolactate sulfo-lyase activity
I6I05_04140	COG0138	bifunctional purine biosynthesis protein purh
I6I05_04150	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I05_04150	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I05_04155	COG0501	Belongs to the peptidase M48B family
I6I05_04175	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I05_04180	COG0445	tRNA wobble uridine modification
I6I05_04185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I05_04190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I05_04195	COG1981	membrane
I6I05_04200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I05_04205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I05_04210	COG0424	maF-like protein
I6I05_04215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I05_04220	COG0237	dephospho-CoA kinase activity
I6I05_04230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
I6I05_04245	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6I05_04270	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I05_04285	COG0135	phosphoribosylanthranilate isomerase activity
I6I05_04290	COG0133	tryptophan synthase activity
I6I05_04295	COG0159	tryptophan synthase activity
I6I05_04300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I05_04305	COG0285	dihydrofolate synthase activity
I6I05_04315	COG1074	ATP-dependent DNA helicase activity
I6I05_04325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I05_04330	COG0802	atpase or kinase
I6I05_04335	COG2205	protein histidine kinase activity
I6I05_04340	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I05_04345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I05_04350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I05_04350	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I05_04355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I05_04360	COG0642	Histidine kinase
I6I05_04365	COG0745	RESPONSE REGULATOR receiver
I6I05_04370	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I05_04380	COG1652	LysM domain
I6I05_04385	COG1072	(Pantothenic acid kinase))
I6I05_04390	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I05_04395	COG0107	imidazoleglycerol-phosphate synthase activity
I6I05_04400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I05_04405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I05_04415	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I05_04420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I05_04425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I05_04435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6I05_04450	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6I05_04460	COG1643	Atp-dependent helicase
I6I05_04495	COG0514	ATP-dependent DNA helicase (RecQ)
I6I05_04520	COG1072	(Pantothenic acid kinase))
I6I05_04530	COG1780	Probably involved in ribonucleotide reductase function
I6I05_04550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I05_04575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_04590	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I05_04595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I05_04600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I05_04605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I05_04610	COG3064	Membrane
I6I05_04610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I05_04625	COG0779	Required for maturation of 30S ribosomal subunits
I6I05_04630	COG2814	Major facilitator Superfamily
I6I05_04640	COG2951	lytic endotransglycosylase activity
I6I05_04645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I05_04655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I05_04660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I05_04675	COG2816	NAD+ diphosphatase activity
I6I05_04680	COG1605	Chorismate mutase
I6I05_04680	COG0077	Prephenate dehydratase
I6I05_04685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
I6I05_04690	COG3474	cytochrome
I6I05_04700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I05_04705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I05_04710	COG1278	Cold shock
I6I05_04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I05_04725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I05_04725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I05_04735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I05_04765	COG2900	Belongs to the SlyX family
I6I05_04775	COG0484	heat shock protein binding
I6I05_04780	COG0443	Heat shock 70 kDa protein
I6I05_04795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I05_04805	COG3845	ABC transporter
I6I05_04810	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I05_04815	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I05_04820	COG0295	cytidine deaminase activity
I6I05_04830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I05_04835	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I05_04845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I05_04850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I05_04855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I05_04865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I05_04870	COG1845	cytochrome c oxidase, subunit III
I6I05_04875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I05_04880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I05_04885	COG0477	Major facilitator Superfamily
I6I05_04890	COG0067	glutamate synthase
I6I05_04890	COG0069	glutamate synthase activity
I6I05_04890	COG0070	glutamate synthase
I6I05_04895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I05_04910	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I05_04920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I05_04950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_04970	COG0848	biopolymer transport protein
I6I05_04980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I05_04995	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I05_05000	COG3454	Phosphonate metabolism
I6I05_05005	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I05_05010	COG3639	organic phosphonate transmembrane transporter activity
I6I05_05015	COG3639	organic phosphonate transmembrane transporter activity
I6I05_05025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I05_05035	COG4778	phosphonate C-P lyase system protein PhnL
I6I05_05040	COG4107	phosphonate C-P lyase system protein PhnK
I6I05_05045	COG3627	carbon phosphorus lyase activity
I6I05_05050	COG3626	phosphonate metabolism
I6I05_05055	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6I05_05060	COG3624	Phosphonate C-P lyase system protein PhnG
I6I05_05065	COG2188	Transcriptional regulator
I6I05_05070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I05_05075	COG0837	glucose binding
I6I05_05080	COG1803	Methylglyoxal synthase
I6I05_05085	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
I6I05_05090	COG4166	transmembrane transport
I6I05_05095	COG4174	ABC transporter (Permease)
I6I05_05100	COG4239	(ABC) transporter, permease
I6I05_05105	COG4172	Belongs to the ABC transporter superfamily
I6I05_05110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_05115	COG0174	glutamine synthetase
I6I05_05120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_05125	COG3265	gluconokinase activity
I6I05_05130	COG1174	glycine betaine transport
I6I05_05135	COG1125	glycine betaine transport
I6I05_05140	COG1174	glycine betaine transport
I6I05_05145	COG1732	Glycine betaine
I6I05_05155	COG1959	2 iron, 2 sulfur cluster binding
I6I05_05160	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_05180	COG0697	spore germination
I6I05_05195	COG0791	NLP P60 protein
I6I05_05205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I05_05210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I05_05245	COG4964	Belongs to the GSP D family
I6I05_05290	COG3422	double-strand break repair
I6I05_05295	COG3757	hydrolase, family 25
I6I05_05300	COG0697	spore germination
I6I05_05305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I05_05335	COG0481	GTPase activity
I6I05_05340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I05_05370	COG1917	Cupin 2, conserved barrel domain protein
I6I05_05370	COG2169	Transcriptional regulator
I6I05_05375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I05_05400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I05_05405	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I05_05410	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I05_05420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I05_05425	COG0072	phenylalanine-tRNA ligase activity
I6I05_05425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I05_05430	COG0667	Aldo Keto reductase
I6I05_05450	COG4977	sequence-specific DNA binding
I6I05_05475	COG1570	exodeoxyribonuclease VII activity
I6I05_05480	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_05490	COG1846	Transcriptional regulator
I6I05_05495	COG0697	spore germination
I6I05_05500	COG2309	aminopeptidase activity
I6I05_05510	COG1393	Belongs to the ArsC family
I6I05_05525	COG0519	Catalyzes the synthesis of GMP from XMP
I6I05_05525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I05_05540	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I05_05570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6I05_05580	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I05_05590	COG1968	undecaprenyl-diphosphatase activity
I6I05_05605	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I05_05615	COG3963	phosphatidate phosphatase activity
I6I05_05625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I05_05630	COG0792	nuclease activity
I6I05_05645	COG1175	transmembrane transport
I6I05_05650	COG0395	ABC-type sugar transport system, permease component
I6I05_05655	COG3842	ATPase activity
I6I05_05665	COG0189	ligase activity
I6I05_05675	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I05_05680	COG1280	lysine exporter protein (LysE YggA)
I6I05_05685	COG0756	dUTP diphosphatase activity
I6I05_05690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I05_05695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I05_05710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6I05_05715	COG2226	methyltransferase
I6I05_05720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I05_05725	COG1024	Enoyl-CoA hydratase
I6I05_05730	COG0268	Binds directly to 16S ribosomal RNA
I6I05_05735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I05_05740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I05_05745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I05_05750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I05_05755	COG1420	regulation of RNA biosynthetic process
I6I05_05760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I05_05765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I05_05770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I05_05780	COG1137	ATPase activity
I6I05_05785	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6I05_05795	COG0616	signal peptide processing
I6I05_05800	COG0776	regulation of translation
I6I05_05815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I05_05820	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I05_05835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I05_05840	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I05_05845	COG0728	peptidoglycan biosynthetic process
I6I05_05855	COG0180	Tryptophanyl-tRNA synthetase
I6I05_05865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I05_05870	COG1214	PFAM Peptidase M22, glycoprotease
I6I05_05875	COG1214	PFAM Peptidase M22, glycoprotease
I6I05_05875	COG0456	acetyltransferase
I6I05_05890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I05_05895	COG1702	phosphate starvation-inducible protein PhoH
I6I05_05900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I05_05910	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6I05_05915	COG1396	sequence-specific DNA binding
I6I05_05920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I05_05925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I05_05930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_05940	COG0242	peptide deformylase activity
I6I05_05945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I05_05950	COG0101	tRNA pseudouridine synthase activity
I6I05_05960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I05_05965	COG2171	N-acyltransferase activity
I6I05_05975	COG0840	transmembrane signaling receptor activity
I6I05_05985	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I05_06010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I05_06020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I05_06025	COG0706	membrane insertase activity
I6I05_06030	COG0594	ribonuclease P activity
I6I05_06035	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I05_06040	COG0840	transmembrane signaling receptor activity
I6I05_06055	COG2226	methyltransferase
I6I05_06060	COG3842	ATPase activity
I6I05_06065	COG1175	transmembrane transport
I6I05_06070	COG0395	ABC-type sugar transport system, permease component
I6I05_06085	COG0427	acetyl-CoA hydrolase
I6I05_06095	COG3938	Belongs to the proline racemase family
I6I05_06100	COG0418	dihydroorotase activity
I6I05_06105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I05_06125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I05_06130	COG0166	Belongs to the GPI family
I6I05_06135	COG0318	PFAM AMP-dependent synthetase and ligase
I6I05_06140	COG3842	ATPase activity
I6I05_06145	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_06150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I05_06155	COG4774	siderophore transport
I6I05_06195	COG2326	polyphosphate kinase activity
I6I05_06200	COG5002	protein histidine kinase activity
I6I05_06205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I05_06210	COG0573	inorganic phosphate transmembrane transporter activity
I6I05_06220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I05_06225	COG0704	Plays a role in the regulation of phosphate uptake
I6I05_06230	COG0745	RESPONSE REGULATOR receiver
I6I05_06240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I05_06245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I05_06255	COG2967	ApaG domain
I6I05_06265	COG0717	Belongs to the dCTP deaminase family
I6I05_06275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I05_06325	COG0167	dihydroorotate dehydrogenase activity
I6I05_06340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I05_06360	COG1959	2 iron, 2 sulfur cluster binding
I6I05_06365	COG1201	RNA secondary structure unwinding
I6I05_06395	COG1960	acyl-CoA dehydrogenase activity
I6I05_06400	COG0183	Belongs to the thiolase family
I6I05_06405	COG1024	Enoyl-CoA hydratase
I6I05_06405	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I05_06425	COG1320	monovalent cation:proton antiporter activity
I6I05_06430	COG2212	antiporter activity
I6I05_06435	COG1863	multisubunit Na H antiporter MnhE subunit
I6I05_06440	COG0651	ATP synthesis coupled electron transport
I6I05_06445	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I05_06450	COG2111	Na H antiporter
I6I05_06450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I05_06460	COG0840	transmembrane signaling receptor activity
I6I05_06470	COG0745	RESPONSE REGULATOR receiver
I6I05_06475	COG2198	Histidine kinase
I6I05_06475	COG0643	Histidine kinase
I6I05_06480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I05_06485	COG2201	protein-glutamate methylesterase activity
I6I05_06490	COG0745	RESPONSE REGULATOR receiver
I6I05_06495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I6I05_06505	COG1766	The M ring may be actively involved in energy transduction
I6I05_06510	COG2771	luxR family
I6I05_06520	COG2972	Histidine kinase
I6I05_06520	COG0840	transmembrane signaling receptor activity
I6I05_06530	COG1970	mechanosensitive ion channel activity
I6I05_06535	COG0436	Aminotransferase
I6I05_06550	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6I05_06555	COG0424	maF-like protein
I6I05_06560	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I05_06570	COG5328	Belongs to the UPF0262 family
I6I05_06575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I05_06585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I05_06600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I05_06615	COG1338	Plays a role in the flagellum-specific transport system
I6I05_06625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6I05_06635	COG1706	bacterial-type flagellum-dependent cell motility
I6I05_06640	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6I05_06645	COG4786	Flagellar basal body rod
I6I05_06650	COG1677	Flagellar hook-basal body complex protein FliE
I6I05_06655	COG1558	bacterial-type flagellum-dependent cell motility
I6I05_06660	COG1815	bacterial-type flagellum-dependent cell motility
I6I05_06670	COG1157	protein secretion by the type III secretion system
I6I05_06675	COG4786	Flagellar basal body rod
I6I05_06685	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6I05_06690	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I05_06695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I05_06700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6I05_06705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I05_06725	COG1360	Flagellar Motor Protein
I6I05_06750	COG1749	Flagellar hook protein flgE
I6I05_06770	COG5443	negative regulation of bacterial-type flagellum assembly
I6I05_06775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6I05_06785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6I05_06825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I05_06830	COG1609	Transcriptional regulator
I6I05_06835	COG1653	transport
I6I05_06840	COG1175	transmembrane transport
I6I05_06845	COG0395	ABC-type sugar transport system, permease component
I6I05_06850	COG0366	Alpha amylase catalytic
I6I05_06855	COG3842	ATPase activity
I6I05_06870	COG0129	dihydroxy-acid dehydratase activity
I6I05_06875	COG0363	glucosamine-6-phosphate deaminase activity
I6I05_06880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I05_06890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_06900	COG2081	HI0933 family
I6I05_06920	COG2224	Isocitrate lyase
I6I05_06935	COG3842	ATPase activity
I6I05_06940	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_06945	COG1177	transmembrane transport
I6I05_06955	COG2205	protein histidine kinase activity
I6I05_06965	COG0248	Ppx GppA phosphatase
I6I05_06970	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I6I05_06975	COG0477	Major facilitator Superfamily
I6I05_07005	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I05_07010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I05_07020	COG0142	geranyltranstransferase activity
I6I05_07045	COG0752	glycyl-tRNA synthetase alpha subunit
I6I05_07050	COG1704	LemA family
I6I05_07055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I05_07065	COG0751	glycine-tRNA ligase activity
I6I05_07080	COG1683	Conserved Protein
I6I05_07085	COG0840	transmembrane signaling receptor activity
I6I05_07095	COG0151	Belongs to the GarS family
I6I05_07100	COG2183	response to ionizing radiation
I6I05_07105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I05_07130	COG0583	DNA-binding transcription factor activity
I6I05_07150	COG0306	phosphate transporter
I6I05_07160	COG0561	phosphatase activity
I6I05_07165	COG0438	transferase activity, transferring glycosyl groups
I6I05_07170	COG2186	Transcriptional regulator
I6I05_07180	COG0583	DNA-binding transcription factor activity
I6I05_07185	COG0277	FAD linked oxidase domain protein
I6I05_07190	COG0277	FAD linked oxidase domain protein
I6I05_07195	COG0247	lactate metabolic process
I6I05_07205	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_07210	COG2818	Glycosylase
I6I05_07220	COG2855	membrane
I6I05_07225	COG0583	DNA-binding transcription factor activity
I6I05_07245	COG0124	histidyl-tRNA synthetase
I6I05_07255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I05_07260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I05_07265	COG2259	Doxx family
I6I05_07275	COG0459	protein refolding
I6I05_07280	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I05_07290	COG0196	riboflavin kinase activity
I6I05_07295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I05_07305	COG0590	tRNA wobble adenosine to inosine editing
I6I05_07310	COG1187	pseudouridine synthase activity
I6I05_07315	COG0742	ribosomal rna small subunit methyltransferase
I6I05_07320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I05_07330	COG0312	modulator of DNA gyrase
I6I05_07345	COG1519	Transferase
I6I05_07355	COG1663	tetraacyldisaccharide 4'-kinase activity
I6I05_07370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I05_07375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_07375	COG2205	protein histidine kinase activity
I6I05_07380	COG3300	MHYT domain
I6I05_07380	COG5001	Diguanylate cyclase
I6I05_07385	COG3386	PFAM SMP-30 Gluconolaconase
I6I05_07390	COG0800	Aldolase
I6I05_07395	COG3734	2-keto-3-deoxy-galactonokinase
I6I05_07400	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_07405	COG1414	Transcriptional regulator
I6I05_07410	COG2197	response regulator
I6I05_07425	COG0598	Magnesium transport protein CorA
I6I05_07430	COG3158	transport of potassium into the cell
I6I05_07445	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I05_07455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I05_07460	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I05_07470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I05_07490	COG0009	L-threonylcarbamoyladenylate synthase
I6I05_07500	COG4638	Rieske (2fe-2S)
I6I05_07525	COG1960	acyl-CoA dehydrogenase activity
I6I05_07540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I05_07545	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6I05_07550	COG0840	transmembrane signaling receptor activity
I6I05_07575	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I05_07580	COG1741	Belongs to the pirin family
I6I05_07585	COG1722	exodeoxyribonuclease VII activity
I6I05_07590	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I05_07595	COG1268	BioY protein
I6I05_07600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I05_07605	COG1122	ATPase activity
I6I05_07610	COG3214	Protein conserved in bacteria
I6I05_07615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I05_07615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I05_07620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I05_07640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I05_07645	COG0484	heat shock protein binding
I6I05_07655	COG0259	pyridoxamine-phosphate oxidase activity
I6I05_07670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I05_07680	COG0312	modulator of DNA gyrase
I6I05_07700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I05_07705	COG0109	protoheme IX farnesyltransferase activity
I6I05_07710	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6I05_07725	COG3346	SURF1 family
I6I05_07730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I05_07735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6I05_07740	COG0328	RNA-DNA hybrid ribonuclease activity
I6I05_07755	COG0678	peroxiredoxin activity
I6I05_07755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I05_07765	COG1678	Uncharacterized ACR, COG1678
I6I05_07785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I05_07790	COG0612	Peptidase, M16
I6I05_07805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I05_07825	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I05_07845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I05_07850	COG1196	nuclear chromosome segregation
I6I05_07855	COG2514	catechol 2,3-dioxygenase activity
I6I05_07860	COG0574	Belongs to the PEP-utilizing enzyme family
I6I05_07860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I05_07870	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
I6I05_07875	COG1823	symporter activity
I6I05_07895	COG0579	oxidoreductase
I6I05_07925	COG2895	sulfate adenylyltransferase (ATP) activity
I6I05_07930	COG0175	sulfate reduction
I6I05_07935	COG0175	sulfate reduction
I6I05_07940	COG1959	2 iron, 2 sulfur cluster binding
I6I05_07945	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6I05_07950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6I05_07955	COG4208	sulfate ABC transporter
I6I05_07960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I05_07970	COG2200	EAL domain
I6I05_07970	COG2199	diguanylate cyclase activity
I6I05_07970	COG2203	Gaf domain
I6I05_07980	COG1309	transcriptional regulator
I6I05_07985	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_07990	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I05_08030	COG1846	Transcriptional regulator
I6I05_08035	COG0477	Major facilitator Superfamily
I6I05_08045	COG1793	dna ligase
I6I05_08045	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6I05_08060	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_08065	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_08080	COG1846	Transcriptional regulator
I6I05_08085	COG1764	response to oxidative stress
I6I05_08100	COG0488	(ABC) transporter
I6I05_08135	COG0583	DNA-binding transcription factor activity
I6I05_08140	COG4221	oxidoreductase activity
I6I05_08150	COG0433	COG0433 Predicted ATPase
I6I05_08160	COG1733	regulation of RNA biosynthetic process
I6I05_08165	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I6I05_08175	COG1280	lysine exporter protein (LysE YggA)
I6I05_08180	COG0656	L-ascorbic acid biosynthetic process
I6I05_08195	COG4106	trans-aconitate 2-methyltransferase activity
I6I05_08200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I05_08205	COG0840	transmembrane signaling receptor activity
I6I05_08210	COG0583	DNA-binding transcription factor activity
I6I05_08225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I05_08245	COG3909	cytochrome
I6I05_08250	COG2010	Cytochrome c
I6I05_08280	COG0789	Transcriptional regulator
I6I05_08295	COG1230	cation diffusion facilitator family transporter
I6I05_08310	COG4176	ABC-type proline glycine betaine transport system permease component
I6I05_08330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_08340	COG2169	Transcriptional regulator
I6I05_08340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I05_08350	COG2514	catechol 2,3-dioxygenase activity
I6I05_08370	COG1272	protein, Hemolysin III
I6I05_08380	COG1280	lysine exporter protein (LysE YggA)
I6I05_08385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I05_08390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I05_08390	COG2111	Na H antiporter
I6I05_08395	COG2111	Na H antiporter
I6I05_08400	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I05_08405	COG0651	ATP synthesis coupled electron transport
I6I05_08410	COG1863	multisubunit Na H antiporter MnhE subunit
I6I05_08415	COG2212	antiporter activity
I6I05_08420	COG1320	monovalent cation:proton antiporter activity
I6I05_08425	COG4957	zinc ion binding
I6I05_08440	COG2166	iron-sulfur cluster assembly
I6I05_08450	COG2205	protein histidine kinase activity
I6I05_08495	COG0583	DNA-binding transcription factor activity
I6I05_08505	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I05_08510	COG2983	Belongs to the UPF0260 family
I6I05_08555	COG1621	beta-fructofuranosidase activity
I6I05_08560	COG2202	Pas domain
I6I05_08560	COG3920	Histidine kinase
I6I05_08565	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I05_08615	COG4695	Portal protein
I6I05_08720	COG4235	cytochrome complex assembly
I6I05_08725	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
I6I05_08730	COG1138	Cytochrome C-type biogenesis protein
I6I05_08735	COG3088	subunit of a heme lyase
I6I05_08740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I05_08745	COG0745	RESPONSE REGULATOR receiver
I6I05_08755	COG3011	Protein conserved in bacteria
I6I05_08765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I05_08770	COG2205	protein histidine kinase activity
I6I05_08770	COG2202	Pas domain
I6I05_08780	COG0308	aminopeptidase N
I6I05_08800	COG0443	Heat shock 70 kDa protein
I6I05_08810	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_08840	COG0604	alcohol dehydrogenase
I6I05_08845	COG1733	regulation of RNA biosynthetic process
I6I05_08850	COG1968	undecaprenyl-diphosphatase activity
I6I05_08855	COG2239	Acts as a magnesium transporter
I6I05_08860	COG2814	Major facilitator Superfamily
I6I05_08880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I05_08910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I05_08955	COG0741	lytic transglycosylase activity
I6I05_08960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_08965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I05_08970	COG0840	transmembrane signaling receptor activity
I6I05_08980	COG1758	RNA polymerase activity
I6I05_09000	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I05_09005	COG0681	Belongs to the peptidase S26 family
I6I05_09010	COG0571	ribonuclease III activity
I6I05_09015	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I05_09020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I05_09025	COG0784	Response regulator, receiver
I6I05_09030	COG1381	Involved in DNA repair and RecF pathway recombination
I6I05_09040	COG2226	methyltransferase
I6I05_09050	COG1418	mRNA catabolic process
I6I05_09060	COG0346	lactoylglutathione lyase activity
I6I05_09075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_09080	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I05_09085	COG0668	transmembrane transport
I6I05_09095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6I05_09100	COG0354	folic acid binding
I6I05_09125	COG1742	UPF0060 membrane protein
I6I05_09140	COG1183	phosphatidylcholine synthase activity
I6I05_09145	COG0688	phosphatidylethanolamine metabolic process
I6I05_09150	COG5265	(ABC) transporter
I6I05_09195	COG2852	Protein conserved in bacteria
I6I05_09200	COG0215	cysteine-tRNA ligase activity
I6I05_09205	COG4221	oxidoreductase activity
I6I05_09210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I05_09215	COG1286	toxin biosynthetic process
I6I05_09235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I05_09245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I05_09255	COG0305	Participates in initiation and elongation during chromosome replication
I6I05_09280	COG0359	binds to the 23S rRNA
I6I05_09290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I05_09295	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I05_09300	COG0667	Aldo Keto reductase
I6I05_09305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I05_09315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I05_09320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I05_09325	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I05_09330	COG1561	YicC-like family, N-terminal region
I6I05_09335	COG0194	GDP metabolic process
I6I05_09345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I05_09350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I05_09360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6I05_09375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I05_09395	COG3706	GGDEF domain
I6I05_09395	COG5001	Diguanylate cyclase
I6I05_09395	COG2203	Gaf domain
I6I05_09395	COG4251	negative regulation of phosphorylation
I6I05_09405	COG0488	(ABC) transporter
I6I05_09410	COG3706	GGDEF domain
I6I05_09420	COG0105	UTP biosynthetic process
I6I05_09440	COG0314	molybdopterin synthase activity
I6I05_09450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I05_09455	COG0322	excinuclease ABC activity
I6I05_09460	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_09470	COG0625	glutathione transferase activity
I6I05_09485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6I05_09490	COG0243	molybdopterin cofactor binding
I6I05_09505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I05_09510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I05_09515	COG0628	permease
I6I05_09525	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I05_09530	COG0248	Ppx GppA phosphatase
I6I05_09535	COG0456	acetyltransferase
I6I05_09560	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
I6I05_09570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I05_09575	COG0477	Major facilitator Superfamily
I6I05_09580	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I05_09585	COG4452	Inner membrane protein CreD
I6I05_09590	COG0659	secondary active sulfate transmembrane transporter activity
I6I05_09600	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I05_09605	COG3654	unkown
I6I05_09610	COG2336	PFAM SpoVT AbrB
I6I05_09615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
I6I05_09625	COG0113	porphobilinogen synthase activity
I6I05_09645	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I05_09650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I05_09655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I05_09655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I05_09665	COG1280	lysine exporter protein (LysE YggA)
I6I05_09670	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I05_09675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I05_09680	COG2814	Major facilitator Superfamily
I6I05_09685	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
I6I05_09705	COG0416	fatty acid biosynthetic process
I6I05_09710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I05_09715	COG0776	regulation of translation
I6I05_09750	COG0601	transmembrane transport
I6I05_09755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_09760	COG0444	Belongs to the ABC transporter superfamily
I6I05_09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I05_09785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I05_09800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I05_09805	COG0583	DNA-binding transcription factor activity
I6I05_09815	COG0737	Belongs to the 5'-nucleotidase family
I6I05_09840	COG2897	thiosulfate sulfurtransferase activity
I6I05_09855	COG0415	Belongs to the DNA photolyase family
I6I05_09865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I05_09895	COG3932	Exopolysaccharide synthesis, ExoD
I6I05_09900	COG1238	metal cluster binding
I6I05_09915	COG4139	cobalamin transport
I6I05_09920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I05_09925	COG3794	PFAM blue (type 1) copper domain protein
I6I05_09930	COG1528	Iron-storage protein
I6I05_10000	COG1612	heme a metabolic process
I6I05_10010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I05_10015	COG0010	Belongs to the arginase family
I6I05_10020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I05_10025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I05_10040	COG1832	CoA-binding protein
I6I05_10055	COG2124	cytochrome p450
I6I05_10060	COG2199	diguanylate cyclase activity
I6I05_10065	COG0740	serine-type endopeptidase activity
I6I05_10070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I05_10075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I05_10085	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I05_10110	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I05_10115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I05_10120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I05_10130	COG0649	NAD binding
I6I05_10140	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6I05_10145	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6I05_10155	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I6I05_10160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6I05_10170	COG0713	ATP synthesis coupled electron transport
I6I05_10185	COG1007	ATP synthesis coupled electron transport
I6I05_10190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I05_10190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I05_10205	COG0442	prolyl-tRNA aminoacylation
I6I05_10215	COG1136	(ABC) transporter
I6I05_10230	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I05_10240	COG0784	Response regulator, receiver
I6I05_10250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I05_10255	COG0477	Major facilitator Superfamily
I6I05_10270	COG0557	exoribonuclease II activity
I6I05_10275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I05_10285	COG0758	DNA mediated transformation
I6I05_10290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I05_10300	COG0540	Belongs to the ATCase OTCase family
I6I05_10305	COG1960	acyl-CoA dehydrogenase activity
I6I05_10310	COG0456	acetyltransferase
I6I05_10330	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I05_10335	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I05_10340	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I05_10345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I05_10350	COG0154	amidase activity
I6I05_10355	COG3811	Belongs to the UPF0386 family
I6I05_10370	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I05_10380	COG0456	acetyltransferase
I6I05_10395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6I05_10405	COG0511	ligase activity, forming carbon-carbon bonds
I6I05_10410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I05_10420	COG0436	Aminotransferase
I6I05_10440	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_10445	COG1530	ribonuclease E activity
I6I05_10455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I05_10475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I05_10480	COG0384	phenazine biosynthesis protein PhzF
I6I05_10495	COG0633	Ferredoxin
I6I05_10510	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I05_10515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I05_10525	COG3768	UPF0283 membrane protein
I6I05_10530	COG3106	COG3106 Predicted ATPase
I6I05_10560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I05_10595	COG0537	adenosine 5'-monophosphoramidase activity
I6I05_10620	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I05_10625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I05_10630	COG0528	UMP kinase activity
I6I05_10635	COG0233	cytoplasmic translational termination
I6I05_10640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I05_10650	COG0750	zinc metalloprotease
I6I05_10655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I05_10660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I05_10665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I05_10670	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I05_10675	COG3494	Protein of unknown function (DUF1009)
I6I05_10680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6I05_10685	COG0372	Belongs to the citrate synthase family
I6I05_10700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I05_10710	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6I05_10715	COG0148	phosphopyruvate hydratase activity
I6I05_10725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I05_10730	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I05_10730	COG0022	dehydrogenase e1 component
I6I05_10735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I05_10745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I05_10755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I05_10760	COG0697	spore germination
I6I05_10780	COG2867	negative regulation of translational initiation
I6I05_10790	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I05_10790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I05_10800	COG3852	Histidine kinase
I6I05_10805	COG2204	response regulator
I6I05_10810	COG5000	phosphorelay sensor kinase activity
I6I05_10815	COG2204	response regulator
I6I05_10820	COG0569	domain protein
I6I05_10825	COG1923	regulation of RNA biosynthetic process
I6I05_10830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I05_10835	COG3956	TIGRFAM MazG family protein
I6I05_10845	COG1648	precorrin-2 dehydrogenase activity
I6I05_10845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I05_10885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I05_10885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I05_10890	COG0509	glycine decarboxylation via glycine cleavage system
I6I05_10895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I05_10925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I05_10930	COG0564	pseudouridine synthase activity
I6I05_10955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I05_10965	COG1671	Belongs to the UPF0178 family
I6I05_10975	COG0450	alkyl hydroperoxide reductase
I6I05_10980	COG0625	glutathione transferase activity
I6I05_11020	COG2801	Transposase and inactivated derivatives
I6I05_11025	COG0583	DNA-binding transcription factor activity
I6I05_11030	COG2828	Protein conserved in bacteria
I6I05_11045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_11050	COG4191	Histidine kinase
I6I05_11050	COG0784	Response regulator, receiver
I6I05_11055	COG0784	Response regulator, receiver
I6I05_11060	COG2202	Pas domain
I6I05_11060	COG3920	Histidine kinase
I6I05_11065	COG0784	Response regulator, receiver
I6I05_11065	COG4191	Histidine kinase
I6I05_11095	COG0673	inositol 2-dehydrogenase activity
I6I05_11105	COG1609	Transcriptional regulator
I6I05_11110	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_11115	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_11120	COG1129	ABC transporter
I6I05_11125	COG1879	ABC-type sugar transport system periplasmic component
I6I05_11130	COG0328	RNA-DNA hybrid ribonuclease activity
I6I05_11140	COG2226	methyltransferase
I6I05_11150	COG0321	lipoyl(octanoyl) transferase activity
I6I05_11150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I05_11155	COG0084	hydrolase, TatD family'
I6I05_11160	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I05_11170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I05_11380	COG3750	Belongs to the UPF0335 family
I6I05_11440	COG1396	sequence-specific DNA binding
I6I05_11470	COG0326	Molecular chaperone. Has ATPase activity
I6I05_11485	COG0582	viral genome integration into host DNA
I6I05_11520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I05_11525	COG2095	MarC family integral membrane protein
I6I05_11530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I05_11530	COG0617	tRNA 3'-terminal CCA addition
I6I05_11530	COG0517	IMP dehydrogenase activity
I6I05_11535	COG0629	single-stranded DNA binding
I6I05_11540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I05_11550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I05_11555	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I05_11570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I05_11575	COG1121	(ABC) transporter
I6I05_11595	COG0667	Aldo Keto reductase
I6I05_11605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I05_11680	COG2239	Acts as a magnesium transporter
I6I05_11685	COG0243	molybdopterin cofactor binding
I6I05_11695	COG0242	peptide deformylase activity
I6I05_11720	COG0321	lipoyl(octanoyl) transferase activity
I6I05_11725	COG1064	alcohol dehydrogenase
I6I05_11755	COG1862	Preprotein translocase
I6I05_11775	COG2124	cytochrome p450
I6I05_11790	COG0596	Alpha beta hydrolase
I6I05_11800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I05_11805	COG0626	cystathionine gamma-synthase activity
I6I05_11810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_11815	COG4597	amino acid ABC transporter
I6I05_11820	COG0765	amino acid transport
I6I05_11825	COG1126	abc transporter atp-binding protein
I6I05_11840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I05_11855	COG0436	Aminotransferase
I6I05_11885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I05_11895	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I05_11900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I05_11905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I05_11920	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6I05_11925	COG1489	DNA binding
I6I05_11930	COG0024	Methionine aminopeptidase
I6I05_11935	COG2003	Belongs to the UPF0758 family
I6I05_11950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I05_11965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I05_11970	COG0546	phosphoglycolate phosphatase activity
I6I05_11980	COG0114	fumarate hydratase activity
I6I05_11990	COG0504	CTP synthase activity
I6I05_12000	COG0149	triose-phosphate isomerase activity
I6I05_12010	COG0187	DNA topoisomerase II activity
I6I05_12015	COG0740	serine-type endopeptidase activity
I6I05_12025	COG0640	Transcriptional regulator
I6I05_12030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I05_12035	COG0745	RESPONSE REGULATOR receiver
I6I05_12055	COG3264	Mechanosensitive ion channel
I6I05_12055	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6I05_12125	COG1127	ABC transporter
I6I05_12130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6I05_12135	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_12145	COG0280	phosphate acetyltransferase
I6I05_12145	COG0281	malic enzyme
I6I05_12155	COG0778	Nitroreductase
I6I05_12160	COG0823	Involved in the tonB-independent uptake of proteins
I6I05_12175	COG1368	sulfuric ester hydrolase activity
I6I05_12205	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I05_12225	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I05_12245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6I05_12280	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I05_12280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I05_12285	COG0343	queuine tRNA-ribosyltransferase activity
I6I05_12290	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I05_12305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I05_12320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I05_12325	COG0134	indole-3-glycerol-phosphate synthase activity
I6I05_12330	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I05_12335	COG0303	'Molybdopterin
I6I05_12340	COG3706	GGDEF domain
I6I05_12350	COG0475	glutathione-regulated potassium exporter activity
I6I05_12350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I05_12360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I05_12365	COG0697	spore germination
I6I05_12370	COG2814	Major facilitator Superfamily
I6I05_12375	COG0746	molybdenum cofactor guanylyltransferase activity
I6I05_12380	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I05_12385	COG0739	heme binding
I6I05_12390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I05_12395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6I05_12400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I05_12405	COG0805	protein transport
I6I05_12410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I05_12415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I05_12420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I05_12425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I05_12430	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I05_12440	COG0018	arginyl-trna synthetase
I6I05_12445	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I05_12450	COG0316	Belongs to the HesB IscA family
I6I05_12475	COG0525	valine-tRNA ligase activity
I6I05_12485	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I05_12510	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I05_12515	COG1058	Belongs to the CinA family
I6I05_12515	COG1546	Belongs to the CinA family
I6I05_12520	COG0589	response to stress
I6I05_12525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I05_12535	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I05_12545	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I05_12560	COG1132	(ABC) transporter
I6I05_12565	COG0628	permease
I6I05_12600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I05_12610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I05_12620	COG0302	gtp cyclohydrolase
I6I05_12625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I05_12630	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I05_12635	COG0516	GMP reductase activity
I6I05_12635	COG0517	IMP dehydrogenase activity
I6I05_12665	COG1760	l-serine dehydratase
I6I05_12700	COG0583	DNA-binding transcription factor activity
I6I05_12715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I05_12715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I05_12725	COG0347	Belongs to the P(II) protein family
I6I05_12730	COG0174	glutamine synthetase
I6I05_12760	COG0697	spore germination
I6I05_12770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I05_12780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I05_12810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I05_12815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I05_12820	COG2186	Transcriptional regulator
I6I05_12830	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I05_12835	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I05_12840	COG3845	ABC transporter
I6I05_12845	COG1183	phosphatidylcholine synthase activity
I6I05_12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6I05_12855	COG0679	Auxin Efflux Carrier
I6I05_12860	COG0785	Cytochrome C biogenesis protein
I6I05_12890	COG0346	lactoylglutathione lyase activity
I6I05_12895	COG1278	Cold shock
I6I05_12950	COG1136	(ABC) transporter
I6I05_12950	COG0577	efflux transmembrane transporter activity
I6I05_12955	COG0577	efflux transmembrane transporter activity
I6I05_12955	COG1136	(ABC) transporter
I6I05_12970	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I05_12975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I05_12980	COG0719	Fe-S assembly protein
I6I05_12985	COG0396	ATPase activity
I6I05_12990	COG0719	Fe-S assembly protein
I6I05_12995	COG1104	cysteine desulfurase activity
I6I05_13000	COG2945	thiolester hydrolase activity
I6I05_13005	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6I05_13010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I05_13020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I05_13025	COG2833	Protein of unknown function (DUF455)
I6I05_13030	COG0739	heme binding
I6I05_13035	COG0513	Belongs to the DEAD box helicase family
I6I05_13060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I05_13070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I05_13075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I05_13080	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I05_13095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I05_13105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I05_13130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6I05_13135	COG2814	Major facilitator Superfamily
I6I05_13140	COG0483	inositol monophosphate 1-phosphatase activity
I6I05_13145	COG0483	inositol monophosphate 1-phosphatase activity
I6I05_13150	COG0037	tRNA processing
I6I05_13155	COG2066	Belongs to the glutaminase family
I6I05_13160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I05_13165	COG0861	Integral membrane protein TerC family
I6I05_13185	COG1280	lysine exporter protein (LysE YggA)
I6I05_13195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I05_13200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6I05_13210	COG0538	isocitrate dehydrogenase activity
I6I05_13225	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I05_13230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I05_13235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_13240	COG2313	pseudouridylate synthase activity
I6I05_13250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_13255	COG4215	(ABC) transporter
I6I05_13265	COG5425	PFAM Usg family protein
I6I05_13275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I05_13280	COG1522	sequence-specific DNA binding
I6I05_13285	COG1573	uracil-dna glycosylase
I6I05_13295	COG2205	protein histidine kinase activity
I6I05_13295	COG2202	Pas domain
I6I05_13305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I05_13310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6I05_13325	COG0842	Transport permease protein
I6I05_13330	COG1131	(ABC) transporter
I6I05_13335	COG0730	response to heat
I6I05_13345	COG0840	transmembrane signaling receptor activity
I6I05_13345	COG0840	transmembrane signaling receptor activity
I6I05_13355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I05_13360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I05_13375	COG0129	dihydroxy-acid dehydratase activity
I6I05_13380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I05_13385	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6I05_13395	COG3739	integral membrane protein
I6I05_13405	COG0203	ribosomal protein L17
I6I05_13410	COG0202	RNA polymerase activity
I6I05_13415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I05_13420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I05_13425	COG0563	adenylate kinase activity
I6I05_13430	COG0201	protein transport
I6I05_13435	COG0200	Binds to the 23S rRNA
I6I05_13440	COG1841	ribosomal large subunit assembly
I6I05_13445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I05_13450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I05_13455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I05_13460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I05_13465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I05_13470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I05_13475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I05_13480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I05_13485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I05_13490	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I05_13495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I05_13500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I05_13505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I05_13510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I05_13515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I05_13520	COG0089	rRNA binding
I6I05_13525	COG0088	Forms part of the polypeptide exit tunnel
I6I05_13530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I05_13535	COG0051	transcription antitermination factor activity, RNA binding
I6I05_13540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I05_13545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I05_13550	COG0049	tRNA binding
I6I05_13555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I05_13570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I05_13575	COG0085	RNA polymerase activity
I6I05_13585	COG0222	ribosome binding
I6I05_13590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I05_13595	COG0081	regulation of translation
I6I05_13600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I05_13610	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I05_13625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I05_13630	COG0861	Integral membrane protein TerC family
I6I05_13660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I05_13665	COG1607	acyl-coa hydrolase
I6I05_13690	COG2910	NAD(P)H-binding
I6I05_13695	COG1733	regulation of RNA biosynthetic process
I6I05_13705	COG0556	nucleotide-excision repair
I6I05_13745	COG0484	heat shock protein binding
I6I05_13770	COG3842	ATPase activity
I6I05_13780	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_13785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I05_13800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I05_13810	COG2207	Transcriptional regulator
I6I05_13815	COG1064	alcohol dehydrogenase
I6I05_13820	COG1252	NADH dehydrogenase
I6I05_13825	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6I05_13830	COG2197	response regulator
I6I05_13835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I05_13840	COG1090	epimerase
I6I05_13880	COG0656	L-ascorbic acid biosynthetic process
I6I05_13895	COG0440	acetolactate synthase activity
I6I05_13900	COG0028	Belongs to the TPP enzyme family
I6I05_13910	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I05_13915	COG3830	Belongs to the UPF0237 family
I6I05_13915	COG0560	Phosphoserine phosphatase
I6I05_13925	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_13935	COG0330	HflC and HflK could
I6I05_13940	COG0330	HflC and HflK could
I6I05_13950	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I05_13990	COG0277	FAD linked oxidase domain protein
I6I05_14000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I05_14055	COG1335	isochorismatase
I6I05_14075	COG0006	proline dipeptidase activity
I6I05_14085	COG2264	protein methyltransferase activity
I6I05_14090	COG1999	signal sequence binding
I6I05_14100	COG0835	chemotaxis
I6I05_14110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I05_14115	COG0583	DNA-binding transcription factor activity
I6I05_14125	COG1247	-acetyltransferase
I6I05_14135	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I05_14140	COG1280	lysine exporter protein (LysE YggA)
I6I05_14150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6I05_14160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I05_14165	COG0849	cell division
I6I05_14170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I05_14175	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I05_14190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I05_14195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I05_14200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I05_14210	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I05_14215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I05_14225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I05_14240	COG0275	rRNA processing
I6I05_14245	COG2001	Belongs to the MraZ family
I6I05_14250	COG3766	membrane
I6I05_14260	COG0754	glutathionylspermidine amidase activity
I6I05_14285	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6I05_14315	COG4106	trans-aconitate 2-methyltransferase activity
I6I05_14335	COG2226	methyltransferase
I6I05_14345	COG2267	carboxylic ester hydrolase activity
I6I05_14350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I05_14365	COG0251	oxidation-reduction process
I6I05_14380	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_14385	COG2814	Major facilitator Superfamily
I6I05_14410	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_14415	COG0174	glutamine synthetase
I6I05_14420	COG0531	amino acid
I6I05_14430	COG1737	Transcriptional regulator
I6I05_14450	COG3842	ATPase activity
I6I05_14510	COG2968	Membrane
I6I05_14520	COG0432	Pfam Uncharacterised protein family UPF0047
I6I05_14535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I05_14540	COG0358	DNA primase activity
I6I05_14550	COG0505	Belongs to the CarA family
I6I05_14555	COG0534	Mate efflux family protein
I6I05_14570	COG2321	neutral zinc metallopeptidase
I6I05_14585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I05_14590	COG3706	GGDEF domain
I6I05_14595	COG1573	uracil-dna glycosylase
I6I05_14605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I05_14615	COG1522	sequence-specific DNA binding
I6I05_14620	COG0492	ferredoxin-NADP+ reductase activity
I6I05_14625	COG0583	DNA-binding transcription factor activity
I6I05_14635	COG1902	pentaerythritol trinitrate reductase activity
I6I05_14660	COG0387	Pfam Sodium calcium exchanger
I6I05_14665	COG0436	Aminotransferase
I6I05_14670	COG2199	diguanylate cyclase activity
I6I05_14670	COG2200	EAL domain
I6I05_14685	COG1278	Cold shock
I6I05_14690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I05_14700	COG1846	Transcriptional regulator
I6I05_14705	COG0745	RESPONSE REGULATOR receiver
I6I05_14710	COG2205	protein histidine kinase activity
I6I05_14715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I05_14735	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I05_14745	COG1496	oxidoreductase activity
I6I05_14760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I05_14770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I05_14785	COG0840	transmembrane signaling receptor activity
I6I05_14790	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_14800	COG5001	Diguanylate cyclase
I6I05_14800	COG3300	MHYT domain
I6I05_14805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I05_14810	COG5001	Diguanylate cyclase
I6I05_14820	COG0193	aminoacyl-tRNA hydrolase activity
I6I05_14830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I05_14850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6I05_14855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I05_14865	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6I05_14865	COG2857	Cytochrome c1
I6I05_14885	COG1132	(ABC) transporter
I6I05_14890	COG1132	(ABC) transporter
I6I05_14900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I05_14915	COG0408	coproporphyrinogen oxidase activity
I6I05_14930	COG0617	tRNA 3'-terminal CCA addition
I6I05_14945	COG0714	Associated with various cellular activities
I6I05_14965	COG0454	-acetyltransferase
I6I05_14970	COG0477	Major facilitator Superfamily
I6I05_14980	COG0435	Glutathione S-transferase
I6I05_14995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I05_15000	COG3135	benzoate transporter
I6I05_15005	COG4944	Protein of unknown function (DUF1109)
I6I05_15020	COG0740	serine-type endopeptidase activity
I6I05_15035	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I05_15040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I05_15065	COG4175	Glycine betaine
I6I05_15080	COG1435	thymidine kinase activity
I6I05_15100	COG2862	Uncharacterized protein family, UPF0114
I6I05_15120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I05_15120	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I05_15130	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I05_15145	COG0366	Alpha amylase catalytic
I6I05_15150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_15165	COG1160	GTP binding
I6I05_15185	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6I05_15195	COG0024	Methionine aminopeptidase
I6I05_15205	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_15215	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I05_15225	COG0583	DNA-binding transcription factor activity
I6I05_15240	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_15265	COG1309	transcriptional regulator
I6I05_15270	COG1686	Belongs to the peptidase S11 family
I6I05_15280	COG2351	hydroxyisourate hydrolase activity
I6I05_15285	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6I05_15310	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6I05_15320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6I05_15320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_15325	COG2205	protein histidine kinase activity
I6I05_15325	COG0784	Response regulator, receiver
I6I05_15325	COG5002	protein histidine kinase activity
I6I05_15330	COG0513	Belongs to the DEAD box helicase family
I6I05_15340	COG2259	Doxx family
I6I05_15345	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_15355	COG2308	Evidence 4 Homologs of previously reported genes of
I6I05_15365	COG1305	Transglutaminase-like
I6I05_15385	COG0588	phosphoglycerate mutase activity
I6I05_15395	COG4214	carbohydrate transport
I6I05_15405	COG4213	ABC transporter substrate-binding protein
I6I05_15440	COG0840	transmembrane signaling receptor activity
I6I05_15460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_15490	COG1215	transferase activity, transferring glycosyl groups
I6I05_15505	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I05_15520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I05_15525	COG2346	COG2346, Truncated hemoglobins
I6I05_15545	COG1309	transcriptional regulator
I6I05_15560	COG0494	nUDIX hydrolase
I6I05_15570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_15575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_15605	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I05_15610	COG0830	nickel cation binding
I6I05_15615	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I05_15630	COG0804	urea catabolic process
I6I05_15635	COG1442	glycosyl transferase family 8
I6I05_15640	COG3755	Protein conserved in bacteria
I6I05_15650	COG0832	Belongs to the urease beta subunit family
I6I05_15655	COG3813	Protein conserved in bacteria
I6I05_15660	COG0831	urea catabolic process
I6I05_15665	COG0829	nickel cation binding
I6I05_15680	COG0411	ABC transporter
I6I05_15690	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I05_15705	COG0174	glutamine synthetase
I6I05_15710	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_15715	COG0784	Response regulator, receiver
I6I05_15715	COG5002	protein histidine kinase activity
I6I05_15715	COG2198	Histidine kinase
I6I05_15760	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I05_15835	COG0564	pseudouridine synthase activity
I6I05_15850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I05_15860	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I05_15885	COG0346	lactoylglutathione lyase activity
I6I05_15895	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I05_15905	COG2832	Protein of unknown function (DUF454)
I6I05_15910	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I05_15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_15920	COG4558	Periplasmic binding protein
I6I05_15930	COG3721	Heme iron utilization protein
I6I05_15950	COG2205	protein histidine kinase activity
I6I05_15990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_15995	COG4605	iron ion homeostasis
I6I05_16000	COG4604	ABC transporter, ATP-binding protein
I6I05_16005	COG0783	Belongs to the Dps family
I6I05_16020	COG0840	transmembrane signaling receptor activity
I6I05_16020	COG2972	Histidine kinase
I6I05_16025	COG0656	L-ascorbic acid biosynthetic process
I6I05_16030	COG2814	Major facilitator Superfamily
I6I05_16040	COG0583	DNA-binding transcription factor activity
I6I05_16045	COG0657	acetylesterase activity
I6I05_16050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_16070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I05_16075	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6I05_16080	COG0288	reversible hydration of carbon dioxide
I6I05_16090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I05_16105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6I05_16110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I05_16115	COG0778	Nitroreductase
I6I05_16120	COG2267	carboxylic ester hydrolase activity
I6I05_16125	COG0251	oxidation-reduction process
I6I05_16130	COG1335	isochorismatase
I6I05_16135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_16145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_16160	COG1175	transmembrane transport
I6I05_16165	COG0395	ABC-type sugar transport system, permease component
I6I05_16170	COG3842	ATPase activity
I6I05_16175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_16185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I05_16200	COG4608	Belongs to the ABC transporter superfamily
I6I05_16205	COG0444	Belongs to the ABC transporter superfamily
I6I05_16210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_16215	COG0601	transmembrane transport
I6I05_16235	COG0392	lysyltransferase activity
I6I05_16235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I05_16275	COG2159	amidohydrolase
I6I05_16280	COG1960	acyl-CoA dehydrogenase activity
I6I05_16305	COG0745	RESPONSE REGULATOR receiver
I6I05_16315	COG1902	pentaerythritol trinitrate reductase activity
I6I05_16315	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I05_16320	COG3842	ATPase activity
I6I05_16330	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_16335	COG1840	ABC-type Fe3 transport system, periplasmic component
I6I05_16355	COG1192	Involved in chromosome partitioning
I6I05_16360	COG2201	protein-glutamate methylesterase activity
I6I05_16365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6I05_16370	COG0835	chemotaxis
I6I05_16375	COG0840	transmembrane signaling receptor activity
I6I05_16380	COG0835	chemotaxis
I6I05_16385	COG2198	Histidine kinase
I6I05_16385	COG0643	Histidine kinase
I6I05_16445	COG0277	FAD linked oxidase domain protein
I6I05_16455	COG1017	nitric oxide dioxygenase activity
I6I05_16455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I05_16490	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I05_16500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_16505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I05_16515	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I05_16540	COG0583	DNA-binding transcription factor activity
I6I05_16545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_16550	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I05_16555	COG4149	molybdate abc transporter
I6I05_16560	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I05_16575	COG2022	thiamine diphosphate biosynthetic process
I6I05_16590	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I05_16595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I05_16605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I05_16625	COG1132	(ABC) transporter
I6I05_16630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I05_16655	COG0438	transferase activity, transferring glycosyl groups
I6I05_16675	COG4166	transmembrane transport
I6I05_16680	COG0601	transmembrane transport
I6I05_16685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_16695	COG0438	transferase activity, transferring glycosyl groups
I6I05_16700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I05_16705	COG3142	Participates in the control of copper homeostasis
I6I05_16725	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_16730	COG1737	Transcriptional regulator
I6I05_16740	COG3842	ATPase activity
I6I05_16750	COG0395	ABC-type sugar transport system, permease component
I6I05_16765	COG2188	Transcriptional regulator
I6I05_16770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I05_16775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I05_16780	COG1940	carbohydrate kinase activity
I6I05_16790	COG0671	phosphoesterase, PA-phosphatase related
I6I05_16795	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I05_16800	COG0156	8-amino-7-oxononanoate synthase activity
I6I05_16810	COG0729	surface antigen
I6I05_16820	COG0835	chemotaxis
I6I05_16830	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I05_16835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I05_16840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I05_16845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I05_16850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I05_16855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I05_16870	COG4974	Belongs to the 'phage' integrase family
I6I05_16895	COG1280	lysine exporter protein (LysE YggA)
I6I05_16905	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I05_16910	COG0567	Dehydrogenase, E1 component
I6I05_16915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I05_16920	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I05_16925	COG0039	L-malate dehydrogenase activity
I6I05_16930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6I05_16965	COG2264	protein methyltransferase activity
I6I05_16980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I05_16985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I05_16990	COG0181	hydroxymethylbilane synthase activity
I6I05_17030	COG1872	DUF167
I6I05_17035	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I05_17045	COG1217	gtp-binding protein TYPA
I6I05_17050	COG0339	signal peptide processing
I6I05_17060	COG1846	Transcriptional regulator
I6I05_17070	COG0137	argininosuccinate synthase activity
I6I05_17080	COG1280	lysine exporter protein (LysE YggA)
I6I05_17085	COG1122	ATPase activity
I6I05_17090	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I05_17100	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I05_17115	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6I05_17120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I05_17125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I05_17135	COG4181	ATPase activity
I6I05_17145	COG0670	Belongs to the BI1 family
I6I05_17160	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I05_17165	COG4133	protoheme IX ABC transporter activity
I6I05_17170	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I05_17175	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I05_17200	COG2917	probably involved in intracellular septation
I6I05_17205	COG0552	protein localization to endoplasmic reticulum
I6I05_17210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I05_17215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I05_17225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I05_17230	COG1605	Chorismate mutase
I6I05_17230	COG0287	Prephenate dehydrogenase
I6I05_17235	COG0228	four-way junction DNA binding
I6I05_17240	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I05_17245	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I05_17255	COG0335	large ribosomal subunit rRNA binding
I6I05_17260	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
I6I05_17265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_17280	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I05_17290	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I6I05_17310	COG0488	(ABC) transporter
I6I05_17320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6I05_17330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I05_17335	COG0142	geranyltranstransferase activity
I6I05_17340	COG2885	chlorophyll binding
I6I05_17345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I05_17350	COG2223	nitrite transmembrane transporter activity
I6I05_17355	COG1349	DNA-binding transcription factor activity
I6I05_17360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I05_17365	COG2197	response regulator
I6I05_17370	COG1132	(ABC) transporter
I6I05_17375	COG3459	Glycosyltransferase 36 associated
I6I05_17380	COG1473	amidohydrolase
I6I05_17385	COG0579	oxidoreductase
I6I05_17420	COG1177	transmembrane transport
I6I05_17425	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_17440	COG2972	Histidine kinase
I6I05_17440	COG0840	transmembrane signaling receptor activity
I6I05_17455	COG3842	ATPase activity
I6I05_17460	COG0006	proline dipeptidase activity
I6I05_17480	COG0300	oxidoreductase activity
I6I05_17485	COG0129	dihydroxy-acid dehydratase activity
I6I05_17490	COG0667	Aldo Keto reductase
I6I05_17500	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_17510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_17515	COG0601	transmembrane transport
I6I05_17520	COG4172	Belongs to the ABC transporter superfamily
I6I05_17530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_17565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_17570	COG4172	Belongs to the ABC transporter superfamily
I6I05_17595	COG3701	Conjugal transfer protein
I6I05_17600	COG3846	protein secretion by the type IV secretion system
I6I05_17610	COG5314	conjugation
I6I05_17615	COG3451	type IV secretory pathway VirB4
I6I05_17630	COG4962	Type ii secretion system protein e
I6I05_17640	COG1192	Involved in chromosome partitioning
I6I05_17645	COG1475	DNA binding
I6I05_17650	COG0640	Transcriptional regulator
I6I05_17660	COG5001	Diguanylate cyclase
I6I05_17660	COG3300	MHYT domain
I6I05_17890	COG4372	Transposase
I6I05_17895	COG3436	PFAM IS66 Orf2 family protein
I6I05_17900	COG2963	transposase activity
I6I05_17910	COG3436	PFAM IS66 Orf2 family protein
I6I05_17980	COG1278	Cold shock
I6I05_18015	COG0546	phosphoglycolate phosphatase activity
I6I05_18120	COG2222	sugar isomerase
I6I05_18130	COG0006	proline dipeptidase activity
I6I05_18225	COG4172	Belongs to the ABC transporter superfamily
I6I05_18230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_18235	COG0601	transmembrane transport
I6I05_18285	COG0583	DNA-binding transcription factor activity
I6I05_18350	COG0406	alpha-ribazole phosphatase activity
I6I05_18360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I05_18415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I05_18430	COG4172	Belongs to the ABC transporter superfamily
I6I05_18435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_18440	COG0601	transmembrane transport
I6I05_18445	COG0747	negative chemotaxis
I6I05_18465	COG0583	DNA-binding transcription factor activity
I6I05_18470	COG2814	Major facilitator Superfamily
I6I05_18490	COG4106	trans-aconitate 2-methyltransferase activity
I6I05_18705	COG1522	sequence-specific DNA binding
I6I05_18715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I05_18720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I05_18725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I05_18730	COG2423	ornithine cyclodeaminase activity
I6I05_18735	COG0006	proline dipeptidase activity
I6I05_18740	COG3608	succinylglutamate desuccinylase aspartoacylase
I6I05_18745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_18750	COG0765	amino acid transport
I6I05_18755	COG0765	amino acid transport
I6I05_18760	COG1126	abc transporter atp-binding protein
I6I05_18770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6I05_18780	COG1309	transcriptional regulator
I6I05_18785	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_18795	COG1595	DNA-templated transcription, initiation
I6I05_18840	COG3046	protein related to deoxyribodipyrimidine photolyase
I6I05_18845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I05_18855	COG5001	Diguanylate cyclase
I6I05_18855	COG2203	Gaf domain
I6I05_18855	COG3706	GGDEF domain
I6I05_18855	COG4251	negative regulation of phosphorylation
I6I05_18860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I05_18880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I05_18925	COG0753	catalase activity
I6I05_18935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6I05_18945	COG0640	Transcriptional regulator
I6I05_18950	COG5265	(ABC) transporter
I6I05_18960	COG3181	Tripartite tricarboxylate transporter family receptor
I6I05_18965	COG2197	response regulator
I6I05_18970	COG3237	CsbD-like
I6I05_19000	COG0456	acetyltransferase
I6I05_19005	COG2223	nitrite transmembrane transporter activity
I6I05_19015	COG3383	formate dehydrogenase (NAD+) activity
I6I05_19040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I05_19045	COG1802	Transcriptional regulator
I6I05_19050	COG4608	Belongs to the ABC transporter superfamily
I6I05_19055	COG0444	Belongs to the ABC transporter superfamily
I6I05_19060	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_19070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_19075	COG0601	transmembrane transport
I6I05_19085	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_19100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I05_19110	COG0765	amino acid transport
I6I05_19115	COG0765	amino acid transport
I6I05_19120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_19135	COG3938	Belongs to the proline racemase family
I6I05_19145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_19155	COG0765	amino acid transport
I6I05_19170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I05_19175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_19185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I05_19190	COG0784	Response regulator, receiver
I6I05_19205	COG0842	Transport permease protein
I6I05_19210	COG1129	ABC transporter
I6I05_19210	COG0842	Transport permease protein
I6I05_19215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_19220	COG1486	melibiose metabolic process
I6I05_19225	COG4172	Belongs to the ABC transporter superfamily
I6I05_19230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_19235	COG0601	transmembrane transport
I6I05_19240	COG0747	negative chemotaxis
I6I05_19245	COG1486	melibiose metabolic process
I6I05_19270	COG1940	carbohydrate kinase activity
I6I05_19275	COG2182	Extracellular solute-binding protein
I6I05_19280	COG1175	transmembrane transport
I6I05_19285	COG0395	ABC-type sugar transport system, permease component
I6I05_19290	COG0165	Argininosuccinate lyase
I6I05_19295	COG3842	ATPase activity
I6I05_19300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_19305	COG3119	arylsulfatase activity
I6I05_19320	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_19345	COG1733	regulation of RNA biosynthetic process
I6I05_19350	COG1120	ATPase activity
I6I05_19355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_19360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_19370	COG4774	siderophore transport
I6I05_19385	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6I05_19400	COG5002	protein histidine kinase activity
I6I05_19405	COG0745	RESPONSE REGULATOR receiver
I6I05_19435	COG1392	Phosphate transport regulator
I6I05_19440	COG0306	phosphate transporter
I6I05_19445	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6I05_19455	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I6I05_19465	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_19470	COG3300	MHYT domain
I6I05_19470	COG5001	Diguanylate cyclase
I6I05_19480	COG0747	negative chemotaxis
I6I05_19490	COG2186	Transcriptional regulator
I6I05_19495	COG0601	transmembrane transport
I6I05_19500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_19505	COG0444	Belongs to the ABC transporter superfamily
I6I05_19510	COG4608	Belongs to the ABC transporter superfamily
I6I05_19515	COG3842	ATPase activity
I6I05_19520	COG0395	ABC-type sugar transport system, permease component
I6I05_19535	COG1233	COG1233 Phytoene dehydrogenase and related
I6I05_19540	COG1609	Transcriptional regulator
I6I05_19555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I05_19560	COG4774	siderophore transport
I6I05_19565	COG1120	ATPase activity
I6I05_19570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_19575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_19580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I05_19590	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I05_19595	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I05_19600	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I05_19605	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I05_19650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I05_19665	COG0438	transferase activity, transferring glycosyl groups
I6I05_19665	COG1216	Glycosyl transferase, family 2
I6I05_19670	COG3754	Rhamnan synthesis protein F
I6I05_19680	COG1132	(ABC) transporter
I6I05_19695	COG0385	Bile acid
I6I05_19745	COG3210	domain, Protein
I6I05_19745	COG3210	domain, Protein
I6I05_19785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6I05_19800	COG1177	transmembrane transport
I6I05_19805	COG3842	ATPase activity
I6I05_19820	COG0483	inositol monophosphate 1-phosphatase activity
I6I05_19825	COG0584	glycerophosphoryl diester phosphodiesterase
I6I05_19835	COG4149	molybdate abc transporter
I6I05_19840	COG3842	ATPase activity
I6I05_19870	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6I05_19880	COG3842	ATPase activity
I6I05_19885	COG1175	transmembrane transport
I6I05_19890	COG0395	ABC-type sugar transport system, permease component
I6I05_19895	COG1609	Transcriptional regulator
I6I05_19905	COG0673	inositol 2-dehydrogenase activity
I6I05_19910	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_19920	COG1609	Transcriptional regulator
I6I05_19925	COG0183	Belongs to the thiolase family
I6I05_19930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6I05_19940	COG1414	Transcriptional regulator
I6I05_19955	COG0583	DNA-binding transcription factor activity
I6I05_19965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I05_19970	COG3485	protocatechuate 3,4-dioxygenase
I6I05_19975	COG3485	protocatechuate 3,4-dioxygenase
I6I05_19985	COG0765	amino acid transport
I6I05_19990	COG0765	amino acid transport
I6I05_19995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_20000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_20005	COG1126	abc transporter atp-binding protein
I6I05_20010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I05_20015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I05_20025	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_20025	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I6I05_20040	COG0747	negative chemotaxis
I6I05_20050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_20065	COG0683	leucine binding
I6I05_20085	COG3842	ATPase activity
I6I05_20095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_20100	COG3962	Belongs to the TPP enzyme family
I6I05_20110	COG3718	enzyme involved in inositol metabolism
I6I05_20115	COG0673	inositol 2-dehydrogenase activity
I6I05_20120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I05_20130	COG1609	Transcriptional regulator
I6I05_20135	COG1846	Transcriptional regulator
I6I05_20145	COG0523	cobalamin synthesis protein
I6I05_20180	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I05_20200	COG0800	Aldolase
I6I05_20205	COG2954	triphosphatase activity
I6I05_20215	COG1054	Belongs to the UPF0176 family
I6I05_20220	COG3300	MHYT domain
I6I05_20220	COG5001	Diguanylate cyclase
I6I05_20230	COG2011	ABC-type metal ion transport system permease component
I6I05_20235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I05_20240	COG0778	Nitroreductase
I6I05_20250	COG2115	Belongs to the xylose isomerase family
I6I05_20255	COG1070	Carbohydrate kinase
I6I05_20260	COG1609	Transcriptional regulator
I6I05_20275	COG1309	transcriptional regulator
I6I05_20280	COG1253	flavin adenine dinucleotide binding
I6I05_20285	COG0471	metal ion transport
I6I05_20285	COG3273	potassium ion transport
I6I05_20290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I05_20295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I05_20305	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I05_20310	COG1121	(ABC) transporter
I6I05_20315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I05_20320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I05_20325	COG5487	UPF0391 membrane protein
I6I05_20330	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_20335	COG1414	Transcriptional regulator
I6I05_20340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I05_20350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I05_20395	COG0395	ABC-type sugar transport system, permease component
I6I05_20400	COG1175	transmembrane transport
I6I05_20410	COG2390	Transcriptional regulator
I6I05_20415	COG4172	Belongs to the ABC transporter superfamily
I6I05_20420	COG1473	amidohydrolase
I6I05_20430	COG0601	transmembrane transport
I6I05_20445	COG0693	protein deglycase activity
I6I05_20455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_20465	COG0747	negative chemotaxis
I6I05_20470	COG0583	DNA-binding transcription factor activity
I6I05_20475	COG4608	Belongs to the ABC transporter superfamily
I6I05_20480	COG0444	Belongs to the ABC transporter superfamily
I6I05_20485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_20490	COG0601	transmembrane transport
I6I05_20495	COG0747	negative chemotaxis
I6I05_20510	COG1473	amidohydrolase
I6I05_20515	COG2814	Major facilitator Superfamily
I6I05_20520	COG0583	DNA-binding transcription factor activity
I6I05_20525	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6I05_20545	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_20555	COG1609	Transcriptional regulator
I6I05_20560	COG0583	DNA-binding transcription factor activity
I6I05_20565	COG1960	acyl-CoA dehydrogenase activity
I6I05_20570	COG1629	transport
I6I05_20570	COG4774	siderophore transport
I6I05_20585	COG1120	ATPase activity
I6I05_20590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_20595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_20605	COG2375	cellular response to nickel ion
I6I05_20615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I05_20620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I05_20620	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I05_20630	COG1169	isochorismate synthase
I6I05_20635	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I05_20640	COG3433	isochorismatase activity
I6I05_20640	COG1535	isochorismatase
I6I05_20645	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_20675	COG0668	transmembrane transport
I6I05_20685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I05_20695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I05_20695	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I05_20705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_20720	COG1609	Transcriptional regulator
I6I05_20725	COG0673	inositol 2-dehydrogenase activity
I6I05_20735	COG1653	transport
I6I05_20740	COG1175	transmembrane transport
I6I05_20745	COG0395	ABC-type sugar transport system, permease component
I6I05_20750	COG3842	ATPase activity
I6I05_20765	COG1253	flavin adenine dinucleotide binding
I6I05_20795	COG3842	ATPase activity
I6I05_20800	COG1178	ABC-type Fe3 transport system permease component
I6I05_20825	COG0483	inositol monophosphate 1-phosphatase activity
I6I05_20835	COG0477	Major facilitator Superfamily
I6I05_20855	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_20865	COG1879	ABC-type sugar transport system periplasmic component
I6I05_20875	COG1063	alcohol dehydrogenase
I6I05_20880	COG1309	transcriptional regulator
I6I05_20900	COG1312	Catalyzes the dehydration of D-mannonate
I6I05_20905	COG0246	Mannitol dehydrogenase
I6I05_20910	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_20925	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_20930	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_20935	COG1129	ABC transporter
I6I05_20940	COG4977	sequence-specific DNA binding
I6I05_20945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_20950	COG4311	Sarcosine oxidase, delta subunit
I6I05_20955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I05_20955	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I05_20975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I05_20980	COG0318	PFAM AMP-dependent synthetase and ligase
I6I05_20990	COG0367	asparagine synthase
I6I05_21000	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6I05_21005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
I6I05_21030	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6I05_21035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_21050	COG1609	Transcriptional regulator
I6I05_21065	COG5001	Diguanylate cyclase
I6I05_21065	COG3300	MHYT domain
I6I05_21075	COG0840	transmembrane signaling receptor activity
I6I05_21080	COG4166	transmembrane transport
I6I05_21085	COG0601	transmembrane transport
I6I05_21090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_21095	COG4172	Belongs to the ABC transporter superfamily
I6I05_21115	COG2986	histidine ammonia-lyase
I6I05_21145	COG1278	Cold shock
I6I05_21165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I05_21170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6I05_21175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6I05_21180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6I05_21185	COG2080	2 iron, 2 sulfur cluster binding
I6I05_21210	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I05_21230	COG0346	lactoylglutathione lyase activity
I6I05_21235	COG0583	DNA-binding transcription factor activity
I6I05_21240	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6I05_21255	COG1846	Transcriptional regulator
I6I05_21260	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_21270	COG0583	DNA-binding transcription factor activity
I6I05_21280	COG0783	Belongs to the Dps family
I6I05_21285	COG2140	Oxalate decarboxylase
I6I05_21295	COG4566	intracellular signal transduction
I6I05_21300	COG4566	intracellular signal transduction
I6I05_21310	COG0492	ferredoxin-NADP+ reductase activity
I6I05_21320	COG2814	Major facilitator Superfamily
I6I05_21325	COG0243	molybdopterin cofactor binding
I6I05_21335	COG0604	alcohol dehydrogenase
I6I05_21340	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_21345	COG1902	pentaerythritol trinitrate reductase activity
I6I05_21350	COG4221	oxidoreductase activity
I6I05_21355	COG1309	transcriptional regulator
I6I05_21375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I05_21380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I05_21420	COG0739	heme binding
I6I05_21420	COG0741	lytic transglycosylase activity
I6I05_21420	COG1196	nuclear chromosome segregation
I6I05_21425	COG0542	response to heat
I6I05_21435	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I05_21440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I05_21450	COG0527	aspartate kinase activity
I6I05_21465	COG0019	diaminopimelate decarboxylase activity
I6I05_21485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I05_21505	COG0784	Response regulator, receiver
I6I05_21520	COG1522	sequence-specific DNA binding
I6I05_21530	COG1116	anion transmembrane transporter activity
I6I05_21535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_21540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I05_21545	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_21550	COG0583	DNA-binding transcription factor activity
I6I05_21555	COG0435	Glutathione S-transferase
I6I05_21565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I05_21570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_21575	COG0189	ligase activity
I6I05_21600	COG0693	protein deglycase activity
I6I05_21610	COG3685	Protein conserved in bacteria
I6I05_21615	COG4993	Dehydrogenase
I6I05_21635	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_21640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I05_21660	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6I05_21670	COG0411	ABC transporter
I6I05_21685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_21700	COG4608	Belongs to the ABC transporter superfamily
I6I05_21705	COG0444	Belongs to the ABC transporter superfamily
I6I05_21710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_21715	COG0601	transmembrane transport
I6I05_21720	COG0747	negative chemotaxis
I6I05_21725	COG0006	proline dipeptidase activity
I6I05_21730	COG4221	oxidoreductase activity
I6I05_21760	COG0539	negative regulation of cytoplasmic translation
I6I05_21765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I05_21795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I05_21800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6I05_21830	COG1294	oxidase, subunit
I6I05_21840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I05_21845	COG4988	ABC transporter
I6I05_21855	COG1063	alcohol dehydrogenase
I6I05_21860	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_21865	COG2084	Dehydrogenase
I6I05_21875	COG1522	sequence-specific DNA binding
I6I05_21880	COG1794	racemase activity, acting on amino acids and derivatives
I6I05_21890	COG0058	SHG alpha-glucan phosphorylase activity
I6I05_21895	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6I05_21900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I05_21905	COG0297	glycogen (starch) synthase activity
I6I05_21910	COG0033	Phosphoglucomutase
I6I05_21915	COG1523	belongs to the glycosyl hydrolase 13 family
I6I05_21940	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I05_21940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I05_21955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_21960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I05_21980	COG1215	transferase activity, transferring glycosyl groups
I6I05_21985	COG2327	Polysaccharide pyruvyl transferase
I6I05_21990	COG0463	Glycosyl transferase, family 2
I6I05_21995	COG2244	polysaccharide biosynthetic process
I6I05_22000	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I05_22005	COG2273	Hydrolase Family 16
I6I05_22010	COG0438	transferase activity, transferring glycosyl groups
I6I05_22015	COG1215	transferase activity, transferring glycosyl groups
I6I05_22020	COG1215	transferase activity, transferring glycosyl groups
I6I05_22025	COG1215	transferase activity, transferring glycosyl groups
I6I05_22030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I05_22035	COG3206	protein involved in exopolysaccharide biosynthesis
I6I05_22035	COG0489	protein tyrosine kinase activity
I6I05_22040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I05_22045	COG0784	Response regulator, receiver
I6I05_22045	COG4191	Histidine kinase
I6I05_22055	COG4176	ABC-type proline glycine betaine transport system permease component
I6I05_22060	COG4175	Glycine betaine
I6I05_22060	COG0517	IMP dehydrogenase activity
I6I05_22075	COG0564	pseudouridine synthase activity
I6I05_22080	COG0500	methyltransferase
I6I05_22090	COG2133	pyrroloquinoline quinone binding
I6I05_22100	COG2197	response regulator
I6I05_22105	COG4585	Histidine kinase
I6I05_22110	COG1879	ABC-type sugar transport system periplasmic component
I6I05_22115	COG1129	ABC transporter
I6I05_22120	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_22130	COG3386	PFAM SMP-30 Gluconolaconase
I6I05_22135	COG2137	regulation of response to DNA damage stimulus
I6I05_22150	COG1120	ATPase activity
I6I05_22165	COG4774	siderophore transport
I6I05_22170	COG0583	DNA-binding transcription factor activity
I6I05_22180	COG2194	sulfuric ester hydrolase activity
I6I05_22190	COG0642	Histidine kinase
I6I05_22195	COG0477	Major facilitator Superfamily
I6I05_22215	COG0673	inositol 2-dehydrogenase activity
I6I05_22220	COG0697	spore germination
I6I05_22230	COG0010	Belongs to the arginase family
I6I05_22245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I05_22250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I05_22255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I05_22265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I05_22315	COG0671	phosphoesterase, PA-phosphatase related
I6I05_22320	COG0745	RESPONSE REGULATOR receiver
I6I05_22325	COG2205	protein histidine kinase activity
I6I05_22345	COG0277	FAD linked oxidase domain protein
I6I05_22360	COG0601	transmembrane transport
I6I05_22365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_22370	COG4172	Belongs to the ABC transporter superfamily
I6I05_22380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_22390	COG0477	Major facilitator Superfamily
I6I05_22395	COG0583	DNA-binding transcription factor activity
I6I05_22435	COG0673	inositol 2-dehydrogenase activity
I6I05_22440	COG0673	inositol 2-dehydrogenase activity
I6I05_22450	COG1175	transmembrane transport
I6I05_22455	COG0395	ABC-type sugar transport system, permease component
I6I05_22460	COG3842	ATPase activity
I6I05_22470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_22475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I05_22485	COG0798	PFAM Bile acid sodium symporter
I6I05_22495	COG0431	NADPH-dependent FMN reductase
I6I05_22505	COG0640	Transcriptional regulator
I6I05_22520	COG0765	amino acid transport
I6I05_22530	COG1126	abc transporter atp-binding protein
I6I05_22535	COG0010	Belongs to the arginase family
I6I05_22540	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6I05_22545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_22550	COG1126	abc transporter atp-binding protein
I6I05_22555	COG0765	amino acid transport
I6I05_22560	COG0765	amino acid transport
I6I05_22565	COG4221	oxidoreductase activity
I6I05_22575	COG0436	Aminotransferase
I6I05_22580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I05_22585	COG1984	allophanate hydrolase subunit 2
I6I05_22600	COG0439	Biotin carboxylase
I6I05_22605	COG0511	ligase activity, forming carbon-carbon bonds
I6I05_22645	COG0402	S-adenosylhomocysteine deaminase activity
I6I05_22650	COG1228	amidohydrolase
I6I05_22655	COG2986	histidine ammonia-lyase
I6I05_22665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I05_22670	COG0596	Alpha beta hydrolase
I6I05_22700	COG1192	Involved in chromosome partitioning
I6I05_22705	COG1475	DNA binding
I6I05_22710	COG1414	Transcriptional regulator
I6I05_22730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I05_22735	COG4771	TonB-dependent receptor
I6I05_22745	COG0366	Alpha amylase catalytic
I6I05_22750	COG4770	biotin carboxylase activity
I6I05_22755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I05_22760	COG4336	lyase activity
I6I05_22765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I05_22770	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I05_22775	COG1802	Transcriptional regulator
I6I05_22780	COG3707	response regulator
I6I05_22790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I05_22795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_22800	COG1116	anion transmembrane transporter activity
I6I05_22805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I05_22815	COG0243	molybdopterin cofactor binding
I6I05_22820	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I05_22820	COG1648	precorrin-2 dehydrogenase activity
I6I05_22835	COG3842	ATPase activity
I6I05_22840	COG3842	ATPase activity
I6I05_22850	COG0395	ABC-type sugar transport system, permease component
I6I05_22865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I05_22880	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I05_22910	COG1879	ABC-type sugar transport system periplasmic component
I6I05_22915	COG1129	ABC transporter
I6I05_22920	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_22930	COG0667	Aldo Keto reductase
I6I05_22935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I05_22940	COG1830	Aldolase
I6I05_22945	COG1070	Carbohydrate kinase
I6I05_22950	COG0840	transmembrane signaling receptor activity
I6I05_22955	COG1846	Transcriptional regulator
I6I05_22960	COG1304	FMN binding
I6I05_22965	COG0488	(ABC) transporter
I6I05_22980	COG2308	Evidence 4 Homologs of previously reported genes of
I6I05_22980	COG2307	Protein conserved in bacteria
I6I05_23030	COG1454	alcohol dehydrogenase
I6I05_23035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6I05_23045	COG0747	negative chemotaxis
I6I05_23050	COG0601	transmembrane transport
I6I05_23055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_23065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_23135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I05_23140	COG2218	PFAM glutamate synthase alpha subunit domain protein
I6I05_23145	COG0069	glutamate synthase activity
I6I05_23150	COG0174	glutamine synthetase
I6I05_23170	COG0765	amino acid transport
I6I05_23175	COG1126	abc transporter atp-binding protein
I6I05_23190	COG2267	carboxylic ester hydrolase activity
I6I05_23200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_23205	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_23225	COG1177	transmembrane transport
I6I05_23230	COG3842	ATPase activity
I6I05_23250	COG0583	DNA-binding transcription factor activity
I6I05_23270	COG3239	Fatty acid desaturase
I6I05_23290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I05_23295	COG2186	Transcriptional regulator
I6I05_23300	COG1027	Aspartate ammonia-lyase
I6I05_23310	COG0252	asparaginase activity
I6I05_23325	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I05_23330	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I05_23335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I05_23340	COG2205	protein histidine kinase activity
I6I05_23355	COG0067	glutamate synthase
I6I05_23355	COG0069	glutamate synthase activity
I6I05_23355	COG0070	glutamate synthase
I6I05_23370	COG2205	protein histidine kinase activity
I6I05_23385	COG2951	lytic endotransglycosylase activity
I6I05_23390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I05_23415	COG0330	HflC and HflK could
I6I05_23420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I05_23425	COG0737	Belongs to the 5'-nucleotidase family
I6I05_23435	COG5310	Homospermidine synthase
I6I05_23445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I05_23450	COG1164	Oligoendopeptidase f
I6I05_23455	COG2204	response regulator
I6I05_23460	COG3108	Peptidase M15
I6I05_23465	COG0469	pyruvate kinase activity
I6I05_23485	COG3750	Belongs to the UPF0335 family
I6I05_23490	COG0457	Tetratricopeptide repeat
I6I05_23495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I05_23500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I05_23505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I05_23535	COG0483	inositol monophosphate 1-phosphatase activity
I6I05_23555	COG1132	(ABC) transporter
I6I05_23560	COG0254	rRNA binding
I6I05_23585	COG3588	fructose-bisphosphate aldolase
I6I05_23590	COG0126	phosphoglycerate kinase activity
I6I05_23630	COG1253	flavin adenine dinucleotide binding
I6I05_23640	COG1692	metallophosphoesterase
I6I05_23655	COG0217	transcriptional regulatory protein
I6I05_23660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_23665	COG0840	transmembrane signaling receptor activity
I6I05_23665	COG2972	Histidine kinase
I6I05_23670	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I05_23675	COG0632	four-way junction helicase activity
I6I05_23680	COG2255	four-way junction helicase activity
I6I05_23695	COG0494	nUDIX hydrolase
I6I05_23705	COG0824	Thioesterase
I6I05_23725	COG0823	Involved in the tonB-independent uptake of proteins
I6I05_23730	COG2885	chlorophyll binding
I6I05_23740	COG0037	tRNA processing
I6I05_23745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I05_23750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I05_23765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I05_23780	COG0482	sulfurtransferase activity
I6I05_23800	COG3118	belongs to the thioredoxin family
I6I05_23810	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I05_23815	COG2373	Large extracellular alpha-helical protein
I6I05_23820	COG4953	penicillin-binding protein 1C
I6I05_23830	COG1473	amidohydrolase
I6I05_23835	COG1686	Belongs to the peptidase S11 family
I6I05_23840	COG0523	cobalamin synthesis protein
I6I05_23845	COG0425	Belongs to the sulfur carrier protein TusA family
I6I05_23850	COG3034	peptidoglycan biosynthetic process
I6I05_23855	COG0825	malonyl-CoA metabolic process
I6I05_23860	COG4974	Belongs to the 'phage' integrase family
I6I05_23870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I05_23875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I05_23910	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I05_23915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I05_23930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I05_23935	COG2226	methyltransferase
I6I05_23940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I05_23945	COG0287	Prephenate dehydrogenase
I6I05_23960	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6I05_23980	COG2884	Cell division ATP-binding protein ftsE
I6I05_24005	COG0019	diaminopimelate decarboxylase activity
I6I05_24015	COG0165	Argininosuccinate lyase
I6I05_24020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I05_24025	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I05_24035	COG2086	electron transfer activity
I6I05_24045	COG2096	Adenosyltransferase
I6I05_24055	COG0300	oxidoreductase activity
I6I05_24065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I05_24075	COG1396	sequence-specific DNA binding
I6I05_24075	COG3800	Transcriptional regulator
I6I05_24080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I05_24085	COG0625	glutathione transferase activity
I6I05_24095	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6I05_24100	COG4770	biotin carboxylase activity
I6I05_24105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I05_24105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6I05_24110	COG0346	lactoylglutathione lyase activity
I6I05_24125	COG4213	ABC transporter substrate-binding protein
I6I05_24130	COG4214	carbohydrate transport
I6I05_24135	COG1129	ABC transporter
I6I05_24145	COG1396	sequence-specific DNA binding
I6I05_24200	COG3833	ABC-type maltose transport systems, permease component
I6I05_24205	COG3842	ATPase activity
I6I05_24220	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I05_24220	COG2273	Hydrolase Family 16
I6I05_24225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I05_24240	COG0438	transferase activity, transferring glycosyl groups
I6I05_24245	COG0438	transferase activity, transferring glycosyl groups
I6I05_24275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I05_24290	COG2244	polysaccharide biosynthetic process
I6I05_24360	COG0653	protein targeting
I6I05_24365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I05_24370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I05_24380	COG0494	nUDIX hydrolase
I6I05_24395	COG2226	methyltransferase
I6I05_24400	COG1040	competence protein
I6I05_24410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I05_24420	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6I05_24435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I05_24440	COG4150	thiosulfate binding
I6I05_24450	COG4208	sulfate ABC transporter
I6I05_24455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I05_24460	COG4335	DNA alkylation repair
I6I05_24475	COG5001	Diguanylate cyclase
I6I05_24480	COG2264	protein methyltransferase activity
I6I05_24495	COG3254	rhamnose metabolic process
I6I05_24500	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_24505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_24510	COG1129	ABC transporter
I6I05_24520	COG1349	DNA-binding transcription factor activity
I6I05_24525	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_24525	COG3347	Dehydrogenase
I6I05_24530	COG4952	isomerase
I6I05_24535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I05_24540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I05_24545	COG1024	Enoyl-CoA hydratase
I6I05_24560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I05_24565	COG1960	acyl-CoA dehydrogenase activity
I6I05_24575	COG0183	Belongs to the thiolase family
I6I05_24580	COG1960	acyl-CoA dehydrogenase activity
I6I05_24590	COG0022	dehydrogenase e1 component
I6I05_24600	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I05_24605	COG2391	methyltransferase activity
I6I05_24615	COG0640	Transcriptional regulator
I6I05_24620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I05_24620	COG3453	Protein conserved in bacteria
I6I05_24630	COG0300	oxidoreductase activity
I6I05_24645	COG2186	Transcriptional regulator
I6I05_24655	COG0601	transmembrane transport
I6I05_24665	COG0444	Belongs to the ABC transporter superfamily
I6I05_24670	COG4608	Belongs to the ABC transporter superfamily
I6I05_24690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24715	COG1473	amidohydrolase
I6I05_24720	COG0747	negative chemotaxis
I6I05_24735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24740	COG0583	DNA-binding transcription factor activity
I6I05_24750	COG0667	Aldo Keto reductase
I6I05_24760	COG0444	Belongs to the ABC transporter superfamily
I6I05_24775	COG0747	negative chemotaxis
I6I05_24785	COG1960	acyl-CoA dehydrogenase activity
I6I05_24805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I05_24820	COG1959	2 iron, 2 sulfur cluster binding
I6I05_24825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_24835	COG1473	amidohydrolase
I6I05_24845	COG1126	abc transporter atp-binding protein
I6I05_24850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_24865	COG1522	sequence-specific DNA binding
I6I05_24870	COG4172	Belongs to the ABC transporter superfamily
I6I05_24875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_24880	COG0601	transmembrane transport
I6I05_24910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_24915	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_24920	COG0473	3-isopropylmalate dehydrogenase activity
I6I05_24925	COG1012	belongs to the aldehyde dehydrogenase family
I6I05_24935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I05_24955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_24960	COG1120	ATPase activity
I6I05_24965	COG3794	PFAM blue (type 1) copper domain protein
I6I05_24970	COG2226	methyltransferase
I6I05_24985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I05_24990	COG1120	ATPase activity
I6I05_24995	COG1595	DNA-templated transcription, initiation
I6I05_25015	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
I6I05_25020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_25025	COG2197	response regulator
I6I05_25030	COG0601	transmembrane transport
I6I05_25035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_25055	COG0747	negative chemotaxis
I6I05_25070	COG1446	asparaginase
I6I05_25075	COG0583	DNA-binding transcription factor activity
I6I05_25080	COG0601	transmembrane transport
I6I05_25085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_25100	COG0747	negative chemotaxis
I6I05_25105	COG1473	amidohydrolase
I6I05_25115	COG1129	ABC transporter
I6I05_25120	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_25125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I05_25130	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
I6I05_25140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I05_25155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_25165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_25170	COG2079	MmgE PrpD family protein
I6I05_25175	COG1126	abc transporter atp-binding protein
I6I05_25180	COG0765	amino acid transport
I6I05_25195	COG0280	phosphate acetyltransferase
I6I05_25195	COG0281	malic enzyme
I6I05_25200	COG0583	DNA-binding transcription factor activity
I6I05_25225	COG1175	transmembrane transport
I6I05_25230	COG0395	ABC-type sugar transport system, permease component
I6I05_25245	COG0673	inositol 2-dehydrogenase activity
I6I05_25255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I05_25260	COG0720	synthase
I6I05_25265	COG0602	queuosine metabolic process
I6I05_25270	COG0673	inositol 2-dehydrogenase activity
I6I05_25280	COG3842	ATPase activity
I6I05_25295	COG1653	transport
I6I05_25300	COG1609	Transcriptional regulator
I6I05_25315	COG2094	Belongs to the DNA glycosylase MPG family
I6I05_25325	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_25335	COG1376	ErfK ybiS ycfS ynhG family protein
I6I05_25340	COG0840	transmembrane signaling receptor activity
I6I05_25345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I05_25360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I05_25365	COG1596	polysaccharide export
I6I05_25370	COG3307	-O-antigen
I6I05_25410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_25435	COG2942	2-epimerase
I6I05_25445	COG1215	transferase activity, transferring glycosyl groups
I6I05_25465	COG1473	amidohydrolase
I6I05_25475	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_25480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I05_25490	COG1301	dicarboxylic acid transport
I6I05_25495	COG4191	Histidine kinase
I6I05_25500	COG2204	response regulator
I6I05_25515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_25520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I05_25525	COG1522	sequence-specific DNA binding
I6I05_25530	COG0351	phosphomethylpyrimidine kinase
I6I05_25535	COG0352	thiamine-phosphate diphosphorylase activity
I6I05_25540	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I05_25545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I05_25550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_25560	COG1501	Belongs to the glycosyl hydrolase 31 family
I6I05_25565	COG0395	ABC-type sugar transport system, permease component
I6I05_25570	COG1175	transmembrane transport
I6I05_25575	COG1653	transport
I6I05_25580	COG3842	ATPase activity
I6I05_25585	COG2188	Transcriptional regulator
I6I05_25595	COG4989	oxidoreductase activity
I6I05_25640	COG0438	transferase activity, transferring glycosyl groups
I6I05_25650	COG0747	negative chemotaxis
I6I05_25655	COG0601	transmembrane transport
I6I05_25665	COG3964	amidohydrolase
I6I05_25680	COG1921	L-seryl-tRNASec selenium transferase activity
I6I05_25685	COG4172	Belongs to the ABC transporter superfamily
I6I05_25690	COG0625	glutathione transferase activity
I6I05_25705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I05_25710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I05_25710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I05_25715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_25730	COG1312	Catalyzes the dehydration of D-mannonate
I6I05_25735	COG1063	alcohol dehydrogenase
I6I05_25740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I05_25750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_25755	COG2186	Transcriptional regulator
I6I05_25760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I05_25765	COG0850	regulation of cytokinetic process
I6I05_25770	COG2894	cell division
I6I05_25775	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I6I05_25790	COG5001	Diguanylate cyclase
I6I05_25805	COG0673	inositol 2-dehydrogenase activity
I6I05_25815	COG1653	transport
I6I05_25820	COG1175	transmembrane transport
I6I05_25825	COG0395	ABC-type sugar transport system, permease component
I6I05_25830	COG3842	ATPase activity
I6I05_25840	COG0673	inositol 2-dehydrogenase activity
I6I05_25875	COG0587	DNA-directed DNA polymerase activity
I6I05_25890	COG2186	Transcriptional regulator
I6I05_25895	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_25900	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_25905	COG1129	ABC transporter
I6I05_25910	COG1879	ABC-type sugar transport system periplasmic component
I6I05_25915	COG0129	dihydroxy-acid dehydratase activity
I6I05_25925	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I05_25930	COG4608	Belongs to the ABC transporter superfamily
I6I05_25940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_25945	COG0601	transmembrane transport
I6I05_25950	COG0747	negative chemotaxis
I6I05_25960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I05_25965	COG5001	Diguanylate cyclase
I6I05_25975	COG3257	ureidoglycine aminohydrolase activity
I6I05_25980	COG3447	MASE1 domain protein
I6I05_25980	COG5001	Diguanylate cyclase
I6I05_25980	COG5002	protein histidine kinase activity
I6I05_25985	COG1129	ABC transporter
I6I05_25990	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I05_25995	COG1879	ABC-type sugar transport system periplasmic component
I6I05_26000	COG0583	DNA-binding transcription factor activity
I6I05_26025	COG3047	cAMP biosynthetic process
I6I05_26035	COG3842	ATPase activity
I6I05_26040	COG0395	ABC-type sugar transport system, permease component
I6I05_26045	COG1175	transmembrane transport
I6I05_26050	COG1653	transport
I6I05_26055	COG0523	cobalamin synthesis protein
I6I05_26070	COG0523	cobalamin synthesis protein
I6I05_26075	COG1121	(ABC) transporter
I6I05_26085	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I05_26095	COG0626	cystathionine gamma-synthase activity
I6I05_26100	COG2182	Extracellular solute-binding protein
I6I05_26110	COG0395	ABC-type sugar transport system, permease component
I6I05_26125	COG0395	ABC-type sugar transport system, permease component
I6I05_26130	COG1175	transmembrane transport
I6I05_26135	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
I6I05_26140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I05_26150	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_26155	COG1063	alcohol dehydrogenase
I6I05_26160	COG1609	Transcriptional regulator
I6I05_26175	COG2084	Dehydrogenase
I6I05_26180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_26190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I05_26195	COG0583	DNA-binding transcription factor activity
I6I05_26200	COG2223	nitrite transmembrane transporter activity
I6I05_26235	COG0667	Aldo Keto reductase
I6I05_26250	COG2186	Transcriptional regulator
I6I05_26255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_26260	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I6I05_26265	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_26270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I05_26275	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_26280	COG3618	amidohydrolase
I6I05_26285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_26305	COG1175	transmembrane transport
I6I05_26310	COG0395	ABC-type sugar transport system, permease component
I6I05_26315	COG3842	ATPase activity
I6I05_26330	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6I05_26355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6I05_26360	COG1136	(ABC) transporter
I6I05_26360	COG0577	efflux transmembrane transporter activity
I6I05_26365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I05_26400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I05_26410	COG1278	Cold shock
I6I05_26415	COG0673	inositol 2-dehydrogenase activity
I6I05_26430	COG0673	inositol 2-dehydrogenase activity
I6I05_26435	COG1309	transcriptional regulator
I6I05_26440	COG1653	transport
I6I05_26445	COG1175	transmembrane transport
I6I05_26450	COG0395	ABC-type sugar transport system, permease component
I6I05_26455	COG3842	ATPase activity
I6I05_26460	COG1082	Xylose isomerase domain protein TIM barrel
I6I05_26475	COG1609	Transcriptional regulator
I6I05_26505	COG1175	transmembrane transport
I6I05_26510	COG0395	ABC-type sugar transport system, permease component
I6I05_26515	COG1116	anion transmembrane transporter activity
I6I05_26520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I05_26525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I05_26535	COG3842	ATPase activity
I6I05_26540	COG0395	ABC-type sugar transport system, permease component
I6I05_26545	COG1175	transmembrane transport
I6I05_26550	COG1653	transport
I6I05_26580	COG3284	Transcriptional regulator
I6I05_26585	COG1063	alcohol dehydrogenase
I6I05_26600	COG2186	Transcriptional regulator
I6I05_26605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_26610	COG0765	amino acid transport
I6I05_26615	COG0765	amino acid transport
I6I05_26625	COG3842	ATPase activity
I6I05_26635	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_26640	COG0395	ABC-type sugar transport system, permease component
I6I05_26650	COG1595	DNA-templated transcription, initiation
I6I05_26690	COG2186	Transcriptional regulator
I6I05_26695	COG0747	negative chemotaxis
I6I05_26700	COG0601	transmembrane transport
I6I05_26705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_26710	COG0405	Gamma-glutamyltransferase
I6I05_26720	COG5002	protein histidine kinase activity
I6I05_26720	COG0784	Response regulator, receiver
I6I05_26720	COG2198	Histidine kinase
I6I05_26740	COG1278	Cold shock
I6I05_26755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_26760	COG0601	transmembrane transport
I6I05_26765	COG0747	negative chemotaxis
I6I05_26775	COG0583	DNA-binding transcription factor activity
I6I05_26790	COG0583	DNA-binding transcription factor activity
I6I05_26795	COG0477	Major facilitator Superfamily
I6I05_26810	COG1522	sequence-specific DNA binding
I6I05_26840	COG0747	negative chemotaxis
I6I05_26845	COG0601	transmembrane transport
I6I05_26850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_26855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_26885	COG3842	ATPase activity
I6I05_26890	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I05_26895	COG1177	transmembrane transport
I6I05_26910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I05_26920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I05_26930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I6I05_26950	COG4178	(ABC) transporter
I6I05_26990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I05_27015	COG2197	response regulator
I6I05_27020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I05_27025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6I05_27035	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I05_27040	COG4310	Domain of unknown function (DUF2172)
I6I05_27045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I05_27050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I05_27055	COG2197	response regulator
I6I05_27090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I05_27110	COG0438	transferase activity, transferring glycosyl groups
I6I05_27125	COG0071	Belongs to the small heat shock protein (HSP20) family
I6I05_27135	COG4948	Mandelate Racemase Muconate Lactonizing
I6I05_27145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I05_27155	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_27165	COG1653	transport
I6I05_27170	COG0395	ABC-type sugar transport system, permease component
I6I05_27175	COG4209	transmembrane transport
I6I05_27180	COG3842	ATPase activity
I6I05_27185	COG1802	Transcriptional regulator
I6I05_27190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_27205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I05_27210	COG0765	amino acid transport
I6I05_27220	COG1126	abc transporter atp-binding protein
I6I05_27225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I05_27230	COG1027	Aspartate ammonia-lyase
I6I05_27240	COG4172	Belongs to the ABC transporter superfamily
I6I05_27245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I05_27250	COG0601	transmembrane transport
I6I05_27255	COG0747	negative chemotaxis
I6I05_27290	COG1522	sequence-specific DNA binding
I6I05_27310	COG1028	Short-chain dehydrogenase reductase Sdr
I6I05_27325	COG1414	Transcriptional regulator
I6I05_27335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6I05_27340	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6I05_27340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6I05_27345	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I05_27350	COG1764	response to oxidative stress
I6I05_27385	COG0596	Alpha beta hydrolase
I6I05_27485	COG3436	PFAM IS66 Orf2 family protein
I6I05_27490	COG4372	Transposase
I6I05_27510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I05_27540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD