locus-tag	class	description
FY137_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY137_00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY137_00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY137_00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY137_00025	COG1420	regulation of RNA biosynthetic process
FY137_00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY137_00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY137_00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY137_00050	COG1137	ATPase activity
FY137_00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY137_00065	COG0616	signal peptide processing
FY137_00070	COG0776	regulation of translation
FY137_00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY137_00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY137_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY137_00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY137_00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY137_00115	COG0728	peptidoglycan biosynthetic process
FY137_00125	COG0180	Tryptophanyl-tRNA synthetase
FY137_00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY137_00140	COG1214	PFAM Peptidase M22, glycoprotease
FY137_00145	COG0456	acetyltransferase
FY137_00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY137_00165	COG1702	phosphate starvation-inducible protein PhoH
FY137_00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY137_00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY137_00185	COG1396	sequence-specific DNA binding
FY137_00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY137_00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY137_00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_00210	COG0242	peptide deformylase activity
FY137_00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY137_00220	COG0101	tRNA pseudouridine synthase activity
FY137_00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY137_00235	COG2171	N-acyltransferase activity
FY137_00245	COG0840	transmembrane signaling receptor activity
FY137_00250	COG1957	nucleoside hydrolase
FY137_00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY137_00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY137_00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY137_00295	COG0706	membrane insertase activity
FY137_00300	COG0594	ribonuclease P activity
FY137_00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY137_00310	COG0840	transmembrane signaling receptor activity
FY137_00325	COG2226	methyltransferase
FY137_00330	COG3842	ATPase activity
FY137_00335	COG1175	transmembrane transport
FY137_00340	COG0395	ABC-type sugar transport system, permease component
FY137_00355	COG0427	acetyl-CoA hydrolase
FY137_00365	COG3938	Belongs to the proline racemase family
FY137_00370	COG0418	dihydroorotase activity
FY137_00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY137_00395	COG0166	Belongs to the GPI family
FY137_00400	COG0318	PFAM AMP-dependent synthetase and ligase
FY137_00405	COG3842	ATPase activity
FY137_00410	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_00415	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY137_00420	COG4774	siderophore transport
FY137_00460	COG2326	polyphosphate kinase activity
FY137_00465	COG5002	protein histidine kinase activity
FY137_00470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY137_00475	COG0573	inorganic phosphate transmembrane transporter activity
FY137_00485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY137_00490	COG0704	Plays a role in the regulation of phosphate uptake
FY137_00495	COG0745	RESPONSE REGULATOR receiver
FY137_00505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY137_00510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY137_00520	COG2967	ApaG domain
FY137_00535	COG0717	Belongs to the dCTP deaminase family
FY137_00545	COG0582	viral genome integration into host DNA
FY137_00575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY137_00585	COG1278	Cold shock
FY137_00650	COG1132	(ABC) transporter
FY137_00665	COG0640	Transcriptional regulator
FY137_00695	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY137_00745	COG0167	dihydroorotate dehydrogenase activity
FY137_00760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY137_00780	COG1959	2 iron, 2 sulfur cluster binding
FY137_00785	COG1201	RNA secondary structure unwinding
FY137_00815	COG1960	acyl-CoA dehydrogenase activity
FY137_00820	COG0183	Belongs to the thiolase family
FY137_00825	COG1024	Enoyl-CoA hydratase
FY137_00825	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY137_00855	COG1320	monovalent cation:proton antiporter activity
FY137_00860	COG2212	antiporter activity
FY137_00865	COG1863	multisubunit Na H antiporter MnhE subunit
FY137_00870	COG0651	ATP synthesis coupled electron transport
FY137_00875	COG1006	Multisubunit Na H antiporter MnhC subunit
FY137_00880	COG2111	Na H antiporter
FY137_00880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY137_00890	COG0840	transmembrane signaling receptor activity
FY137_00900	COG0745	RESPONSE REGULATOR receiver
FY137_00905	COG0643	Histidine kinase
FY137_00905	COG2198	Histidine kinase
FY137_00910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY137_00915	COG2201	protein-glutamate methylesterase activity
FY137_00920	COG0745	RESPONSE REGULATOR receiver
FY137_00925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY137_00935	COG1766	The M ring may be actively involved in energy transduction
FY137_00940	COG2771	luxR family
FY137_00950	COG0840	transmembrane signaling receptor activity
FY137_00950	COG2972	Histidine kinase
FY137_00955	COG0784	Response regulator, receiver
FY137_00955	COG2198	Histidine kinase
FY137_00955	COG2205	protein histidine kinase activity
FY137_00960	COG1970	mechanosensitive ion channel activity
FY137_00965	COG0436	Aminotransferase
FY137_00980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY137_00985	COG0424	maF-like protein
FY137_00990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY137_01000	COG5328	Belongs to the UPF0262 family
FY137_01005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY137_01015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY137_01045	COG1338	Plays a role in the flagellum-specific transport system
FY137_01055	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY137_01065	COG1706	bacterial-type flagellum-dependent cell motility
FY137_01070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY137_01075	COG4786	Flagellar basal body rod
FY137_01080	COG1677	Flagellar hook-basal body complex protein FliE
FY137_01085	COG1558	bacterial-type flagellum-dependent cell motility
FY137_01090	COG1815	bacterial-type flagellum-dependent cell motility
FY137_01100	COG1157	protein secretion by the type III secretion system
FY137_01105	COG4786	Flagellar basal body rod
FY137_01115	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY137_01120	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY137_01125	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY137_01130	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY137_01135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY137_01155	COG1360	Flagellar Motor Protein
FY137_01180	COG1749	Flagellar hook protein flgE
FY137_01200	COG5443	negative regulation of bacterial-type flagellum assembly
FY137_01205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY137_01215	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY137_01255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY137_01260	COG1609	Transcriptional regulator
FY137_01265	COG1653	transport
FY137_01270	COG1175	transmembrane transport
FY137_01275	COG0395	ABC-type sugar transport system, permease component
FY137_01280	COG0366	Alpha amylase catalytic
FY137_01285	COG3842	ATPase activity
FY137_01295	COG3609	addiction module antidote protein, CC2985 family
FY137_01310	COG0129	dihydroxy-acid dehydratase activity
FY137_01315	COG0363	glucosamine-6-phosphate deaminase activity
FY137_01320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY137_01325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_01335	COG2081	HI0933 family
FY137_01355	COG2224	Isocitrate lyase
FY137_01370	COG3842	ATPase activity
FY137_01375	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_01380	COG1177	transmembrane transport
FY137_01390	COG2205	protein histidine kinase activity
FY137_01415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_01430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY137_01435	COG1984	allophanate hydrolase subunit 2
FY137_01440	COG1802	Transcriptional regulator
FY137_01460	COG0006	proline dipeptidase activity
FY137_01485	COG0765	amino acid transport
FY137_01510	COG3665	Urea carboxylase-associated protein
FY137_01515	COG1116	anion transmembrane transporter activity
FY137_01540	COG0395	ABC-type sugar transport system, permease component
FY137_01545	COG3842	ATPase activity
FY137_01555	COG1063	alcohol dehydrogenase
FY137_01560	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_01565	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_01570	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_01575	COG0248	Ppx GppA phosphatase
FY137_01580	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY137_01585	COG0477	Major facilitator Superfamily
FY137_01615	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY137_01620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY137_01630	COG0142	geranyltranstransferase activity
FY137_01665	COG0752	glycyl-tRNA synthetase alpha subunit
FY137_01675	COG1704	LemA family
FY137_01680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY137_01690	COG0751	glycine-tRNA ligase activity
FY137_01695	COG1683	Conserved Protein
FY137_01700	COG0840	transmembrane signaling receptor activity
FY137_01710	COG0151	Belongs to the GarS family
FY137_01715	COG2183	response to ionizing radiation
FY137_01720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY137_01730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FY137_01745	COG0583	DNA-binding transcription factor activity
FY137_01765	COG0306	phosphate transporter
FY137_01775	COG0561	phosphatase activity
FY137_01780	COG0438	transferase activity, transferring glycosyl groups
FY137_01785	COG2186	Transcriptional regulator
FY137_01800	COG0583	DNA-binding transcription factor activity
FY137_01805	COG0277	FAD linked oxidase domain protein
FY137_01810	COG0277	FAD linked oxidase domain protein
FY137_01815	COG0247	lactate metabolic process
FY137_01825	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_01830	COG2818	Glycosylase
FY137_01840	COG2855	membrane
FY137_01845	COG0583	DNA-binding transcription factor activity
FY137_01875	COG0124	histidyl-tRNA synthetase
FY137_01885	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY137_01890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY137_01895	COG2259	Doxx family
FY137_01905	COG0459	protein refolding
FY137_01910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY137_01920	COG0196	riboflavin kinase activity
FY137_01925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY137_01935	COG0590	tRNA wobble adenosine to inosine editing
FY137_01940	COG1187	pseudouridine synthase activity
FY137_01945	COG0742	ribosomal rna small subunit methyltransferase
FY137_01950	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY137_01955	COG0475	glutathione-regulated potassium exporter activity
FY137_01955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY137_01960	COG0312	modulator of DNA gyrase
FY137_01965	COG0483	inositol monophosphate 1-phosphatase activity
FY137_01975	COG1519	Transferase
FY137_01985	COG1663	tetraacyldisaccharide 4'-kinase activity
FY137_01995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY137_02000	COG0745	RESPONSE REGULATOR receiver
FY137_02005	COG3300	MHYT domain
FY137_02005	COG5001	Diguanylate cyclase
FY137_02010	COG3386	PFAM SMP-30 Gluconolaconase
FY137_02015	COG0800	Aldolase
FY137_02020	COG3734	2-keto-3-deoxy-galactonokinase
FY137_02025	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_02030	COG1414	Transcriptional regulator
FY137_02035	COG2197	response regulator
FY137_02050	COG0598	Magnesium transport protein CorA
FY137_02055	COG3158	transport of potassium into the cell
FY137_02070	COG0356	it plays a direct role in the translocation of protons across the membrane
FY137_02080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY137_02085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY137_02095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY137_02115	COG0009	L-threonylcarbamoyladenylate synthase
FY137_02125	COG4638	Rieske (2fe-2S)
FY137_02150	COG1960	acyl-CoA dehydrogenase activity
FY137_02165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY137_02175	COG0840	transmembrane signaling receptor activity
FY137_02185	COG1522	sequence-specific DNA binding
FY137_02215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY137_02220	COG1741	Belongs to the pirin family
FY137_02225	COG1722	exodeoxyribonuclease VII activity
FY137_02230	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY137_02235	COG1268	BioY protein
FY137_02240	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY137_02245	COG1122	ATPase activity
FY137_02250	COG3214	Protein conserved in bacteria
FY137_02255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY137_02255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY137_02260	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY137_02280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY137_02295	COG0259	pyridoxamine-phosphate oxidase activity
FY137_02330	COG0312	modulator of DNA gyrase
FY137_02345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY137_02350	COG0109	protoheme IX farnesyltransferase activity
FY137_02355	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY137_02370	COG3346	SURF1 family
FY137_02375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY137_02380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY137_02385	COG0328	RNA-DNA hybrid ribonuclease activity
FY137_02400	COG0678	peroxiredoxin activity
FY137_02400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY137_02410	COG1678	Uncharacterized ACR, COG1678
FY137_02425	COG5001	Diguanylate cyclase
FY137_02425	COG3300	MHYT domain
FY137_02430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY137_02435	COG0612	Peptidase, M16
FY137_02450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY137_02455	COG1802	Transcriptional regulator
FY137_02470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY137_02480	COG3609	addiction module antidote protein, CC2985 family
FY137_02485	COG3668	Plasmid stabilization system
FY137_02495	COG1194	a g-specific adenine glycosylase
FY137_02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY137_02515	COG1196	nuclear chromosome segregation
FY137_02520	COG2514	catechol 2,3-dioxygenase activity
FY137_02525	COG0574	Belongs to the PEP-utilizing enzyme family
FY137_02525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY137_02545	COG1823	symporter activity
FY137_02570	COG0579	oxidoreductase
FY137_02585	COG2895	sulfate adenylyltransferase (ATP) activity
FY137_02590	COG0175	sulfate reduction
FY137_02595	COG0175	sulfate reduction
FY137_02600	COG1959	2 iron, 2 sulfur cluster binding
FY137_02605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY137_02610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY137_02615	COG4208	sulfate ABC transporter
FY137_02620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY137_02640	COG2203	Gaf domain
FY137_02640	COG2200	EAL domain
FY137_02640	COG2199	diguanylate cyclase activity
FY137_02655	COG1309	transcriptional regulator
FY137_02660	COG1012	belongs to the aldehyde dehydrogenase family
FY137_02665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY137_02710	COG0477	Major facilitator Superfamily
FY137_02720	COG1793	dna ligase
FY137_02720	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY137_02740	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_02745	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_02750	COG1846	Transcriptional regulator
FY137_02755	COG1764	response to oxidative stress
FY137_02770	COG0488	(ABC) transporter
FY137_02800	COG0583	DNA-binding transcription factor activity
FY137_02805	COG4221	oxidoreductase activity
FY137_02820	COG0433	COG0433 Predicted ATPase
FY137_02830	COG1733	regulation of RNA biosynthetic process
FY137_02850	COG0656	L-ascorbic acid biosynthetic process
FY137_02855	COG3781	membrane
FY137_02860	COG2378	regulation of single-species biofilm formation
FY137_02870	COG4106	trans-aconitate 2-methyltransferase activity
FY137_02875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY137_02880	COG0840	transmembrane signaling receptor activity
FY137_02885	COG0583	DNA-binding transcription factor activity
FY137_02900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY137_02920	COG3909	cytochrome
FY137_02925	COG2010	Cytochrome c
FY137_02955	COG0789	Transcriptional regulator
FY137_02980	COG0517	IMP dehydrogenase activity
FY137_02980	COG4175	Glycine betaine
FY137_02985	COG4176	ABC-type proline glycine betaine transport system permease component
FY137_03005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_03015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY137_03015	COG2169	Transcriptional regulator
FY137_03025	COG2514	catechol 2,3-dioxygenase activity
FY137_03045	COG1272	protein, Hemolysin III
FY137_03055	COG1280	lysine exporter protein (LysE YggA)
FY137_03060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY137_03065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY137_03065	COG2111	Na H antiporter
FY137_03070	COG2111	Na H antiporter
FY137_03075	COG1006	Multisubunit Na H antiporter MnhC subunit
FY137_03080	COG0651	ATP synthesis coupled electron transport
FY137_03085	COG1863	multisubunit Na H antiporter MnhE subunit
FY137_03090	COG2212	antiporter activity
FY137_03095	COG1320	monovalent cation:proton antiporter activity
FY137_03100	COG4957	zinc ion binding
FY137_03115	COG2166	iron-sulfur cluster assembly
FY137_03125	COG2205	protein histidine kinase activity
FY137_03175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY137_03180	COG2983	Belongs to the UPF0260 family
FY137_03190	COG2226	methyltransferase
FY137_03220	COG0477	Major facilitator Superfamily
FY137_03230	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY137_03280	COG4695	Portal protein
FY137_03395	COG4235	cytochrome complex assembly
FY137_03400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY137_03405	COG1138	Cytochrome C-type biogenesis protein
FY137_03410	COG3088	subunit of a heme lyase
FY137_03415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY137_03420	COG0745	RESPONSE REGULATOR receiver
FY137_03425	COG2205	protein histidine kinase activity
FY137_03430	COG3011	Protein conserved in bacteria
FY137_03445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY137_03450	COG2202	Pas domain
FY137_03450	COG2205	protein histidine kinase activity
FY137_03460	COG0308	aminopeptidase N
FY137_03465	COG0697	spore germination
FY137_03480	COG0443	Heat shock 70 kDa protein
FY137_03515	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY137_03530	COG0604	alcohol dehydrogenase
FY137_03535	COG1733	regulation of RNA biosynthetic process
FY137_03540	COG1968	undecaprenyl-diphosphatase activity
FY137_03545	COG2239	Acts as a magnesium transporter
FY137_03550	COG2814	Major facilitator Superfamily
FY137_03575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY137_03600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY137_03635	COG2813	Specifically methylates the guanine in position
FY137_03650	COG0741	lytic transglycosylase activity
FY137_03655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_03660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY137_03665	COG0840	transmembrane signaling receptor activity
FY137_03675	COG1758	RNA polymerase activity
FY137_03695	COG0736	holo-[acyl-carrier-protein] synthase activity
FY137_03700	COG0681	Belongs to the peptidase S26 family
FY137_03705	COG0571	ribonuclease III activity
FY137_03710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY137_03715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY137_03720	COG0784	Response regulator, receiver
FY137_03725	COG1381	Involved in DNA repair and RecF pathway recombination
FY137_03745	COG1418	mRNA catabolic process
FY137_03755	COG0346	lactoylglutathione lyase activity
FY137_03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_03780	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY137_03785	COG0668	transmembrane transport
FY137_03795	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY137_03825	COG1742	UPF0060 membrane protein
FY137_03840	COG1183	phosphatidylcholine synthase activity
FY137_03845	COG0688	phosphatidylethanolamine metabolic process
FY137_03850	COG5265	(ABC) transporter
FY137_03895	COG2852	Protein conserved in bacteria
FY137_03900	COG0215	cysteine-tRNA ligase activity
FY137_03905	COG4221	oxidoreductase activity
FY137_03910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY137_03915	COG1286	toxin biosynthetic process
FY137_03935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY137_03945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY137_03955	COG5265	(ABC) transporter
FY137_03960	COG0305	Participates in initiation and elongation during chromosome replication
FY137_03980	COG0359	binds to the 23S rRNA
FY137_03990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY137_03995	COG0360	Binds together with S18 to 16S ribosomal RNA
FY137_04000	COG0667	Aldo Keto reductase
FY137_04005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY137_04015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY137_04020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY137_04025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY137_04030	COG1561	YicC-like family, N-terminal region
FY137_04035	COG0194	GDP metabolic process
FY137_04050	COG0400	carboxylic ester hydrolase activity
FY137_04055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY137_04060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY137_04070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY137_04085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY137_04105	COG3706	GGDEF domain
FY137_04105	COG4251	negative regulation of phosphorylation
FY137_04105	COG5001	Diguanylate cyclase
FY137_04105	COG2203	Gaf domain
FY137_04110	COG3300	MHYT domain
FY137_04110	COG5001	Diguanylate cyclase
FY137_04115	COG0488	(ABC) transporter
FY137_04120	COG3706	GGDEF domain
FY137_04130	COG0105	UTP biosynthetic process
FY137_04150	COG0314	molybdopterin synthase activity
FY137_04160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY137_04165	COG0322	excinuclease ABC activity
FY137_04170	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_04180	COG0625	glutathione transferase activity
FY137_04195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY137_04200	COG0243	molybdopterin cofactor binding
FY137_04225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY137_04230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY137_04240	COG0628	permease
FY137_04250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY137_04255	COG0248	Ppx GppA phosphatase
FY137_04280	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY137_04290	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY137_04295	COG0477	Major facilitator Superfamily
FY137_04300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY137_04305	COG4452	Inner membrane protein CreD
FY137_04310	COG0840	transmembrane signaling receptor activity
FY137_04315	COG0659	secondary active sulfate transmembrane transporter activity
FY137_04325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY137_04335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY137_04345	COG0113	porphobilinogen synthase activity
FY137_04370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY137_04375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY137_04380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY137_04380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY137_04390	COG1280	lysine exporter protein (LysE YggA)
FY137_04395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY137_04400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY137_04405	COG2814	Major facilitator Superfamily
FY137_04410	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY137_04430	COG0416	fatty acid biosynthetic process
FY137_04435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY137_04440	COG0776	regulation of translation
FY137_04470	COG0789	Transcriptional regulator
FY137_04475	COG0601	transmembrane transport
FY137_04480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_04485	COG0444	Belongs to the ABC transporter superfamily
FY137_04505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY137_04510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY137_04525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY137_04530	COG0583	DNA-binding transcription factor activity
FY137_04540	COG0737	Belongs to the 5'-nucleotidase family
FY137_04560	COG2897	thiosulfate sulfurtransferase activity
FY137_04575	COG0415	Belongs to the DNA photolyase family
FY137_04585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY137_04615	COG3932	Exopolysaccharide synthesis, ExoD
FY137_04620	COG1238	metal cluster binding
FY137_04635	COG4139	cobalamin transport
FY137_04640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY137_04645	COG3794	PFAM blue (type 1) copper domain protein
FY137_04650	COG1528	Iron-storage protein
FY137_04715	COG1612	heme a metabolic process
FY137_04725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY137_04730	COG0010	Belongs to the arginase family
FY137_04735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY137_04740	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY137_04750	COG1832	CoA-binding protein
FY137_04760	COG1846	Transcriptional regulator
FY137_04790	COG0740	serine-type endopeptidase activity
FY137_04795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY137_04800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY137_04810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY137_04835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY137_04840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY137_04845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY137_04855	COG0649	NAD binding
FY137_04865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY137_04870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY137_04880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY137_04885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY137_04895	COG0713	ATP synthesis coupled electron transport
FY137_04910	COG1007	ATP synthesis coupled electron transport
FY137_04915	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY137_04915	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY137_04930	COG0442	prolyl-tRNA aminoacylation
FY137_04940	COG1136	(ABC) transporter
FY137_04955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY137_04975	COG0784	Response regulator, receiver
FY137_04985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY137_04990	COG0477	Major facilitator Superfamily
FY137_05005	COG0557	exoribonuclease II activity
FY137_05010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY137_05020	COG0758	DNA mediated transformation
FY137_05025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY137_05035	COG0540	Belongs to the ATCase OTCase family
FY137_05045	COG1960	acyl-CoA dehydrogenase activity
FY137_05050	COG0456	acetyltransferase
FY137_05075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY137_05080	COG2824	Alkylphosphonate utilization operon protein PhnA
FY137_05085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY137_05090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY137_05095	COG0154	amidase activity
FY137_05100	COG0456	acetyltransferase
FY137_05105	COG3811	Belongs to the UPF0386 family
FY137_05120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY137_05130	COG0456	acetyltransferase
FY137_05150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY137_05155	COG0439	Biotin carboxylase
FY137_05160	COG0511	ligase activity, forming carbon-carbon bonds
FY137_05165	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY137_05175	COG0436	Aminotransferase
FY137_05195	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_05200	COG1530	ribonuclease E activity
FY137_05210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY137_05230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY137_05235	COG0384	phenazine biosynthesis protein PhzF
FY137_05250	COG0633	Ferredoxin
FY137_05260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FY137_05265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY137_05270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY137_05280	COG3768	UPF0283 membrane protein
FY137_05285	COG3106	COG3106 Predicted ATPase
FY137_05315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY137_05345	COG0537	adenosine 5'-monophosphoramidase activity
FY137_05370	COG0052	Belongs to the universal ribosomal protein uS2 family
FY137_05375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY137_05380	COG0528	UMP kinase activity
FY137_05385	COG0233	cytoplasmic translational termination
FY137_05390	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY137_05400	COG0750	zinc metalloprotease
FY137_05405	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY137_05410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY137_05415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY137_05420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY137_05425	COG3494	Protein of unknown function (DUF1009)
FY137_05430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY137_05435	COG2186	Transcriptional regulator
FY137_05445	COG0765	amino acid transport
FY137_05450	COG0765	amino acid transport
FY137_05460	COG0372	Belongs to the citrate synthase family
FY137_05475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY137_05480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_05485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_05490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_05495	COG3958	Transketolase
FY137_05500	COG3959	Transketolase, thiamine diphosphate binding domain
FY137_05505	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_05510	COG0583	DNA-binding transcription factor activity
FY137_05520	COG2376	Dihydroxyacetone kinase
FY137_05540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY137_05545	COG0148	phosphopyruvate hydratase activity
FY137_05555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY137_05560	COG0022	dehydrogenase e1 component
FY137_05560	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY137_05565	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY137_05575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY137_05585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY137_05590	COG0697	spore germination
FY137_05605	COG2867	negative regulation of translational initiation
FY137_05610	COG1546	Belongs to the CinA family
FY137_05615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY137_05615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY137_05625	COG3852	Histidine kinase
FY137_05630	COG2204	response regulator
FY137_05635	COG5000	phosphorelay sensor kinase activity
FY137_05640	COG2204	response regulator
FY137_05645	COG0569	domain protein
FY137_05650	COG1923	regulation of RNA biosynthetic process
FY137_05655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY137_05660	COG3956	TIGRFAM MazG family protein
FY137_05670	COG1648	precorrin-2 dehydrogenase activity
FY137_05670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY137_05710	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY137_05710	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY137_05715	COG0509	glycine decarboxylation via glycine cleavage system
FY137_05720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_05745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY137_05770	COG0251	oxidation-reduction process
FY137_05775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY137_05785	COG1671	Belongs to the UPF0178 family
FY137_05800	COG0450	alkyl hydroperoxide reductase
FY137_05810	COG0625	glutathione transferase activity
FY137_05815	COG0456	acetyltransferase
FY137_05835	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY137_05850	COG0436	Aminotransferase
FY137_05870	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_05910	COG0431	NADPH-dependent FMN reductase
FY137_05920	COG0798	PFAM Bile acid sodium symporter
FY137_05925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY137_05940	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_05950	COG0604	alcohol dehydrogenase
FY137_05950	COG3321	synthase
FY137_05955	COG0604	alcohol dehydrogenase
FY137_05955	COG3321	synthase
FY137_05995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY137_05995	COG0321	lipoyl(octanoyl) transferase activity
FY137_06000	COG0084	hydrolase, TatD family'
FY137_06005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY137_06015	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY137_06080	COG1802	Transcriptional regulator
FY137_06080	COG4626	Terminase
FY137_06105	COG0582	viral genome integration into host DNA
FY137_06135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY137_06140	COG2095	MarC family integral membrane protein
FY137_06145	COG0517	IMP dehydrogenase activity
FY137_06145	COG0617	tRNA 3'-terminal CCA addition
FY137_06145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY137_06155	COG0629	single-stranded DNA binding
FY137_06160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY137_06175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY137_06195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY137_06200	COG1121	(ABC) transporter
FY137_06220	COG0667	Aldo Keto reductase
FY137_06230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY137_06305	COG2239	Acts as a magnesium transporter
FY137_06310	COG0243	molybdopterin cofactor binding
FY137_06320	COG0242	peptide deformylase activity
FY137_06330	COG2202	Pas domain
FY137_06330	COG2205	protein histidine kinase activity
FY137_06340	COG0321	lipoyl(octanoyl) transferase activity
FY137_06345	COG1064	alcohol dehydrogenase
FY137_06375	COG1862	Preprotein translocase
FY137_06390	COG1309	transcriptional regulator
FY137_06395	COG2124	cytochrome p450
FY137_06410	COG0596	Alpha beta hydrolase
FY137_06425	COG0626	cystathionine gamma-synthase activity
FY137_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_06435	COG4597	amino acid ABC transporter
FY137_06440	COG0765	amino acid transport
FY137_06445	COG1126	abc transporter atp-binding protein
FY137_06460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY137_06475	COG0436	Aminotransferase
FY137_06505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY137_06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY137_06515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY137_06520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY137_06525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY137_06540	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY137_06545	COG1489	DNA binding
FY137_06550	COG0024	Methionine aminopeptidase
FY137_06555	COG2003	Belongs to the UPF0758 family
FY137_06570	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY137_06585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY137_06590	COG0546	phosphoglycolate phosphatase activity
FY137_06605	COG0114	fumarate hydratase activity
FY137_06615	COG0504	CTP synthase activity
FY137_06625	COG0149	triose-phosphate isomerase activity
FY137_06635	COG0187	DNA topoisomerase II activity
FY137_06655	COG3064	Membrane
FY137_06655	COG3210	domain, Protein
FY137_06655	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
FY137_06695	COG0740	serine-type endopeptidase activity
FY137_06705	COG0640	Transcriptional regulator
FY137_06710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY137_06715	COG0745	RESPONSE REGULATOR receiver
FY137_06740	COG3264	Mechanosensitive ion channel
FY137_06740	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY137_06850	COG1525	nuclease
FY137_06925	COG3567	Phage-associated protein, HI1409 family
FY137_06935	COG5410	chromosome segregation
FY137_06975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY137_07200	COG1127	ABC transporter
FY137_07205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY137_07210	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_07220	COG0280	phosphate acetyltransferase
FY137_07220	COG0281	malic enzyme
FY137_07225	COG0346	lactoylglutathione lyase activity
FY137_07245	COG0778	Nitroreductase
FY137_07250	COG0823	Involved in the tonB-independent uptake of proteins
FY137_07265	COG1368	sulfuric ester hydrolase activity
FY137_07290	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY137_07315	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY137_07335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY137_07350	COG0318	PFAM AMP-dependent synthetase and ligase
FY137_07360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY137_07360	COG0512	Glutamine amidotransferase of anthranilate synthase
FY137_07365	COG0343	queuine tRNA-ribosyltransferase activity
FY137_07370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY137_07385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY137_07405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY137_07410	COG0134	indole-3-glycerol-phosphate synthase activity
FY137_07415	COG0315	cyclic pyranopterin monophosphate synthase activity
FY137_07420	COG0303	'Molybdopterin
FY137_07425	COG3706	GGDEF domain
FY137_07435	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY137_07435	COG0475	glutathione-regulated potassium exporter activity
FY137_07445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY137_07450	COG0697	spore germination
FY137_07455	COG2814	Major facilitator Superfamily
FY137_07460	COG0746	molybdenum cofactor guanylyltransferase activity
FY137_07465	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY137_07470	COG0739	heme binding
FY137_07480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY137_07485	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY137_07490	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY137_07495	COG0805	protein transport
FY137_07500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY137_07505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY137_07510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY137_07515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY137_07520	COG1472	Belongs to the glycosyl hydrolase 3 family
FY137_07530	COG0018	arginyl-trna synthetase
FY137_07535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY137_07565	COG0525	valine-tRNA ligase activity
FY137_07575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY137_07600	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY137_07605	COG1058	Belongs to the CinA family
FY137_07605	COG1546	Belongs to the CinA family
FY137_07610	COG0589	response to stress
FY137_07615	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY137_07620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY137_07630	COG1914	H( )-stimulated, divalent metal cation uptake system
FY137_07640	COG1132	(ABC) transporter
FY137_07645	COG0628	permease
FY137_07680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY137_07690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY137_07700	COG0302	gtp cyclohydrolase
FY137_07705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY137_07710	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY137_07720	COG0516	GMP reductase activity
FY137_07720	COG0517	IMP dehydrogenase activity
FY137_07755	COG1760	l-serine dehydratase
FY137_07790	COG0583	DNA-binding transcription factor activity
FY137_07805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY137_07805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY137_07810	COG0347	Belongs to the P(II) protein family
FY137_07815	COG0174	glutamine synthetase
FY137_07845	COG0697	spore germination
FY137_07850	COG0300	oxidoreductase activity
FY137_07865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY137_07875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY137_07885	COG3668	Plasmid stabilization system
FY137_07890	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FY137_07905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY137_07910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY137_07915	COG2186	Transcriptional regulator
FY137_07925	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY137_07930	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY137_07935	COG3845	ABC transporter
FY137_07940	COG1183	phosphatidylcholine synthase activity
FY137_07945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY137_07950	COG0679	Auxin Efflux Carrier
FY137_07955	COG0785	Cytochrome C biogenesis protein
FY137_07975	COG1278	Cold shock
FY137_08040	COG0667	Aldo Keto reductase
FY137_08070	COG0577	efflux transmembrane transporter activity
FY137_08070	COG1136	(ABC) transporter
FY137_08075	COG0577	efflux transmembrane transporter activity
FY137_08075	COG1136	(ABC) transporter
FY137_08100	COG2151	metal-sulfur cluster biosynthetic enzyme
FY137_08105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY137_08110	COG0719	Fe-S assembly protein
FY137_08115	COG0396	ATPase activity
FY137_08120	COG0719	Fe-S assembly protein
FY137_08125	COG1104	cysteine desulfurase activity
FY137_08130	COG2945	thiolester hydrolase activity
FY137_08135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY137_08140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY137_08150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY137_08155	COG2833	Protein of unknown function (DUF455)
FY137_08160	COG0739	heme binding
FY137_08165	COG0513	Belongs to the DEAD box helicase family
FY137_08190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY137_08200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY137_08205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY137_08210	COG0047	phosphoribosylformylglycinamidine synthase activity
FY137_08225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY137_08230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY137_08255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY137_08260	COG2814	Major facilitator Superfamily
FY137_08265	COG0483	inositol monophosphate 1-phosphatase activity
FY137_08270	COG0483	inositol monophosphate 1-phosphatase activity
FY137_08275	COG0037	tRNA processing
FY137_08280	COG2066	Belongs to the glutaminase family
FY137_08285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY137_08290	COG0861	Integral membrane protein TerC family
FY137_08310	COG1280	lysine exporter protein (LysE YggA)
FY137_08320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY137_08325	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY137_08335	COG0538	isocitrate dehydrogenase activity
FY137_08360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY137_08365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY137_08370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_08375	COG2313	pseudouridylate synthase activity
FY137_08390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_08395	COG4215	(ABC) transporter
FY137_08405	COG5425	PFAM Usg family protein
FY137_08415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_08420	COG1522	sequence-specific DNA binding
FY137_08425	COG1573	uracil-dna glycosylase
FY137_08435	COG2202	Pas domain
FY137_08435	COG2205	protein histidine kinase activity
FY137_08445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY137_08450	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY137_08465	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY137_08470	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_08475	COG1129	ABC transporter
FY137_08485	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_08490	COG3959	Transketolase, thiamine diphosphate binding domain
FY137_08495	COG3958	Transketolase
FY137_08500	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY137_08505	COG2390	Transcriptional regulator
FY137_08515	COG0842	Transport permease protein
FY137_08520	COG1131	(ABC) transporter
FY137_08525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY137_08525	COG0730	response to heat
FY137_08545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY137_08550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY137_08580	COG0129	dihydroxy-acid dehydratase activity
FY137_08585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY137_08590	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY137_08600	COG0203	ribosomal protein L17
FY137_08605	COG0202	RNA polymerase activity
FY137_08610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY137_08615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY137_08620	COG0563	adenylate kinase activity
FY137_08625	COG0201	protein transport
FY137_08630	COG0200	Binds to the 23S rRNA
FY137_08635	COG1841	ribosomal large subunit assembly
FY137_08640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY137_08645	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY137_08650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY137_08655	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY137_08660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY137_08665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY137_08670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY137_08675	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY137_08680	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY137_08685	COG0255	Belongs to the universal ribosomal protein uL29 family
FY137_08690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY137_08695	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY137_08700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY137_08705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY137_08710	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY137_08715	COG0089	rRNA binding
FY137_08720	COG0088	Forms part of the polypeptide exit tunnel
FY137_08725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY137_08730	COG0051	transcription antitermination factor activity, RNA binding
FY137_08735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY137_08740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY137_08745	COG0049	tRNA binding
FY137_08750	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY137_08770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY137_08775	COG0085	RNA polymerase activity
FY137_08780	COG0222	ribosome binding
FY137_08785	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY137_08790	COG0081	regulation of translation
FY137_08795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY137_08805	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY137_08820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY137_08825	COG0861	Integral membrane protein TerC family
FY137_08830	COG3895	Periplasmic Protein
FY137_08860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY137_08865	COG1607	acyl-coa hydrolase
FY137_08885	COG2910	NAD(P)H-binding
FY137_08890	COG1733	regulation of RNA biosynthetic process
FY137_08905	COG0556	nucleotide-excision repair
FY137_08915	COG2382	esterase
FY137_08935	COG0484	heat shock protein binding
FY137_08975	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_08980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY137_08995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY137_09005	COG2207	Transcriptional regulator
FY137_09010	COG1064	alcohol dehydrogenase
FY137_09015	COG1252	NADH dehydrogenase
FY137_09020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY137_09030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY137_09035	COG0702	epimerase
FY137_09075	COG0656	L-ascorbic acid biosynthetic process
FY137_09090	COG0440	acetolactate synthase activity
FY137_09095	COG0028	Belongs to the TPP enzyme family
FY137_09105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY137_09110	COG0560	Phosphoserine phosphatase
FY137_09110	COG3830	Belongs to the UPF0237 family
FY137_09120	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_09130	COG0330	HflC and HflK could
FY137_09135	COG0330	HflC and HflK could
FY137_09145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY137_09185	COG0277	FAD linked oxidase domain protein
FY137_09190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY137_09230	COG1335	isochorismatase
FY137_09255	COG2264	protein methyltransferase activity
FY137_09260	COG1999	signal sequence binding
FY137_09270	COG0835	chemotaxis
FY137_09280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY137_09295	COG1247	-acetyltransferase
FY137_09305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY137_09310	COG0497	DNA recombination
FY137_09315	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY137_09325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY137_09330	COG0849	cell division
FY137_09335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY137_09340	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY137_09345	COG0477	Major facilitator Superfamily
FY137_09350	COG3300	MHYT domain
FY137_09350	COG5001	Diguanylate cyclase
FY137_09355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY137_09360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY137_09365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY137_09375	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY137_09380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY137_09390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY137_09405	COG0275	rRNA processing
FY137_09410	COG2001	Belongs to the MraZ family
FY137_09435	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY137_09440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FY137_09465	COG4106	trans-aconitate 2-methyltransferase activity
FY137_09485	COG2226	methyltransferase
FY137_09495	COG2267	carboxylic ester hydrolase activity
FY137_09500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY137_09530	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_09535	COG2814	Major facilitator Superfamily
FY137_09560	COG1012	belongs to the aldehyde dehydrogenase family
FY137_09565	COG0174	glutamine synthetase
FY137_09570	COG0531	amino acid
FY137_09580	COG1737	Transcriptional regulator
FY137_09585	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_09600	COG3842	ATPase activity
FY137_09705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY137_09715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY137_09725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY137_09730	COG1396	sequence-specific DNA binding
FY137_09745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY137_09805	COG2968	Membrane
FY137_09815	COG0432	Pfam Uncharacterised protein family UPF0047
FY137_09830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY137_09835	COG0358	DNA primase activity
FY137_09855	COG0505	Belongs to the CarA family
FY137_09860	COG0534	Mate efflux family protein
FY137_09875	COG2321	neutral zinc metallopeptidase
FY137_09890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY137_09900	COG3706	GGDEF domain
FY137_09915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY137_09925	COG1522	sequence-specific DNA binding
FY137_09930	COG0492	ferredoxin-NADP+ reductase activity
FY137_09935	COG0583	DNA-binding transcription factor activity
FY137_09945	COG1902	pentaerythritol trinitrate reductase activity
FY137_09970	COG0387	Pfam Sodium calcium exchanger
FY137_09975	COG0436	Aminotransferase
FY137_09980	COG2199	diguanylate cyclase activity
FY137_09980	COG2200	EAL domain
FY137_09995	COG1278	Cold shock
FY137_10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY137_10010	COG1846	Transcriptional regulator
FY137_10015	COG0745	RESPONSE REGULATOR receiver
FY137_10020	COG2205	protein histidine kinase activity
FY137_10025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY137_10045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY137_10055	COG1496	oxidoreductase activity
FY137_10060	COG0006	proline dipeptidase activity
FY137_10070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY137_10095	COG0840	transmembrane signaling receptor activity
FY137_10100	COG1012	belongs to the aldehyde dehydrogenase family
FY137_10105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY137_10110	COG3300	MHYT domain
FY137_10110	COG5001	Diguanylate cyclase
FY137_10115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY137_10120	COG5001	Diguanylate cyclase
FY137_10130	COG0193	aminoacyl-tRNA hydrolase activity
FY137_10140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY137_10160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY137_10170	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY137_10170	COG2857	Cytochrome c1
FY137_10190	COG1132	(ABC) transporter
FY137_10195	COG1132	(ABC) transporter
FY137_10200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FY137_10205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY137_10220	COG0408	coproporphyrinogen oxidase activity
FY137_10235	COG0617	tRNA 3'-terminal CCA addition
FY137_10250	COG0714	Associated with various cellular activities
FY137_10270	COG0454	-acetyltransferase
FY137_10285	COG0477	Major facilitator Superfamily
FY137_10295	COG0435	Glutathione S-transferase
FY137_10310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY137_10315	COG3135	benzoate transporter
FY137_10340	COG0740	serine-type endopeptidase activity
FY137_10355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY137_10360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY137_10385	COG4175	Glycine betaine
FY137_10400	COG1435	thymidine kinase activity
FY137_10420	COG2862	Uncharacterized protein family, UPF0114
FY137_10425	COG1629	transport
FY137_10425	COG4771	TonB-dependent receptor
FY137_10435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY137_10435	COG0512	Glutamine amidotransferase of anthranilate synthase
FY137_10450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY137_10465	COG0366	Alpha amylase catalytic
FY137_10470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_10490	COG1160	GTP binding
FY137_10510	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY137_10520	COG0024	Methionine aminopeptidase
FY137_10530	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_10540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FY137_10550	COG0583	DNA-binding transcription factor activity
FY137_10565	COG0402	S-adenosylhomocysteine deaminase activity
FY137_10585	COG1309	transcriptional regulator
FY137_10590	COG1686	Belongs to the peptidase S11 family
FY137_10595	COG4115	mRNA cleavage
FY137_10610	COG2351	hydroxyisourate hydrolase activity
FY137_10615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY137_10640	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY137_10650	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY137_10650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_10655	COG2205	protein histidine kinase activity
FY137_10655	COG5002	protein histidine kinase activity
FY137_10655	COG0784	Response regulator, receiver
FY137_10660	COG0513	Belongs to the DEAD box helicase family
FY137_10670	COG2259	Doxx family
FY137_10675	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_10685	COG2308	Evidence 4 Homologs of previously reported genes of
FY137_10695	COG1305	Transglutaminase-like
FY137_10720	COG4214	carbohydrate transport
FY137_10730	COG4213	ABC transporter substrate-binding protein
FY137_10765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY137_10805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_10820	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_10840	COG4974	Belongs to the 'phage' integrase family
FY137_10845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_10855	COG4191	Histidine kinase
FY137_10870	COG0702	epimerase
FY137_10875	COG1073	alpha beta
FY137_10880	COG1073	alpha beta
FY137_10885	COG0583	DNA-binding transcription factor activity
FY137_10890	COG0840	transmembrane signaling receptor activity
FY137_10895	COG2814	Major facilitator Superfamily
FY137_10905	COG0646	methionine synthase
FY137_10905	COG1410	methionine synthase
FY137_10950	COG1215	transferase activity, transferring glycosyl groups
FY137_10980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY137_10985	COG2346	COG2346, Truncated hemoglobins
FY137_11005	COG1309	transcriptional regulator
FY137_11020	COG0494	nUDIX hydrolase
FY137_11030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_11035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_11060	COG1234	tRNA 3'-trailer cleavage
FY137_11065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY137_11070	COG0830	nickel cation binding
FY137_11075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY137_11090	COG0804	urea catabolic process
FY137_11095	COG1442	glycosyl transferase family 8
FY137_11100	COG3755	Protein conserved in bacteria
FY137_11110	COG0832	Belongs to the urease beta subunit family
FY137_11115	COG3813	Protein conserved in bacteria
FY137_11120	COG0831	urea catabolic process
FY137_11125	COG0829	nickel cation binding
FY137_11145	COG0411	ABC transporter
FY137_11155	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY137_11170	COG0174	glutamine synthetase
FY137_11175	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_11180	COG5002	protein histidine kinase activity
FY137_11180	COG2198	Histidine kinase
FY137_11180	COG0784	Response regulator, receiver
FY137_11195	COG0726	polysaccharide deacetylase
FY137_11230	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY137_11305	COG0564	pseudouridine synthase activity
FY137_11315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY137_11325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY137_11365	COG0346	lactoylglutathione lyase activity
FY137_11375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY137_11385	COG2832	Protein of unknown function (DUF454)
FY137_11390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY137_11395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_11400	COG4558	Periplasmic binding protein
FY137_11410	COG3721	Heme iron utilization protein
FY137_11435	COG2205	protein histidine kinase activity
FY137_11475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_11480	COG4605	iron ion homeostasis
FY137_11485	COG4604	ABC transporter, ATP-binding protein
FY137_11490	COG0783	Belongs to the Dps family
FY137_11505	COG0656	L-ascorbic acid biosynthetic process
FY137_11510	COG2814	Major facilitator Superfamily
FY137_11520	COG0583	DNA-binding transcription factor activity
FY137_11525	COG0657	acetylesterase activity
FY137_11530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_11550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY137_11555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY137_11560	COG0288	reversible hydration of carbon dioxide
FY137_11570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY137_11585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY137_11590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY137_11595	COG0778	Nitroreductase
FY137_11600	COG2267	carboxylic ester hydrolase activity
FY137_11605	COG0251	oxidation-reduction process
FY137_11610	COG1335	isochorismatase
FY137_11615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_11625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_11640	COG1175	transmembrane transport
FY137_11645	COG0395	ABC-type sugar transport system, permease component
FY137_11650	COG3842	ATPase activity
FY137_11655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_11680	COG4608	Belongs to the ABC transporter superfamily
FY137_11685	COG0444	Belongs to the ABC transporter superfamily
FY137_11690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_11695	COG0601	transmembrane transport
FY137_11700	COG4166	transmembrane transport
FY137_11750	COG2159	amidohydrolase
FY137_11755	COG1960	acyl-CoA dehydrogenase activity
FY137_11780	COG0450	alkyl hydroperoxide reductase
FY137_11805	COG0745	RESPONSE REGULATOR receiver
FY137_11815	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY137_11815	COG1902	pentaerythritol trinitrate reductase activity
FY137_11820	COG3842	ATPase activity
FY137_11830	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_11835	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_11840	COG0745	RESPONSE REGULATOR receiver
FY137_11850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY137_11855	COG0583	DNA-binding transcription factor activity
FY137_11870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FY137_11880	COG2223	nitrite transmembrane transporter activity
FY137_11885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY137_11910	COG0765	amino acid transport
FY137_11915	COG0765	amino acid transport
FY137_11960	COG3609	addiction module antidote protein, CC2985 family
FY137_12000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY137_12010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_12015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY137_12025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY137_12030	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY137_12035	COG1509	lysine 2,3-aminomutase activity
FY137_12050	COG0583	DNA-binding transcription factor activity
FY137_12055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_12060	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY137_12065	COG4149	molybdate abc transporter
FY137_12070	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY137_12085	COG2022	thiamine diphosphate biosynthetic process
FY137_12100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY137_12105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY137_12115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY137_12140	COG1132	(ABC) transporter
FY137_12145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY137_12190	COG4166	transmembrane transport
FY137_12200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_12210	COG0438	transferase activity, transferring glycosyl groups
FY137_12215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY137_12220	COG3142	Participates in the control of copper homeostasis
FY137_12225	COG2814	Major facilitator Superfamily
FY137_12240	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_12245	COG1737	Transcriptional regulator
FY137_12255	COG3842	ATPase activity
FY137_12265	COG0395	ABC-type sugar transport system, permease component
FY137_12285	COG2188	Transcriptional regulator
FY137_12290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY137_12295	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY137_12300	COG1940	carbohydrate kinase activity
FY137_12310	COG0671	phosphoesterase, PA-phosphatase related
FY137_12315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY137_12320	COG0156	8-amino-7-oxononanoate synthase activity
FY137_12330	COG0729	surface antigen
FY137_12340	COG0835	chemotaxis
FY137_12350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY137_12355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY137_12360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY137_12365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY137_12370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY137_12375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY137_12390	COG4974	Belongs to the 'phage' integrase family
FY137_12415	COG1280	lysine exporter protein (LysE YggA)
FY137_12425	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY137_12430	COG0567	Dehydrogenase, E1 component
FY137_12435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY137_12440	COG0045	succinate-CoA ligase (ADP-forming) activity
FY137_12445	COG0039	L-malate dehydrogenase activity
FY137_12450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY137_12485	COG2264	protein methyltransferase activity
FY137_12500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY137_12505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY137_12510	COG0181	hydroxymethylbilane synthase activity
FY137_12550	COG1872	DUF167
FY137_12555	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY137_12565	COG1217	gtp-binding protein TYPA
FY137_12570	COG0339	signal peptide processing
FY137_12580	COG1846	Transcriptional regulator
FY137_12585	COG2814	Major facilitator Superfamily
FY137_12590	COG0137	argininosuccinate synthase activity
FY137_12600	COG1280	lysine exporter protein (LysE YggA)
FY137_12605	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY137_12610	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY137_12620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY137_12635	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY137_12640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY137_12645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY137_12655	COG4181	ATPase activity
FY137_12665	COG0670	Belongs to the BI1 family
FY137_12680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY137_12685	COG4133	protoheme IX ABC transporter activity
FY137_12690	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY137_12695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY137_12720	COG2917	probably involved in intracellular septation
FY137_12725	COG0552	protein localization to endoplasmic reticulum
FY137_12730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY137_12735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY137_12745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY137_12750	COG0287	Prephenate dehydrogenase
FY137_12750	COG1605	Chorismate mutase
FY137_12755	COG0228	four-way junction DNA binding
FY137_12760	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY137_12765	COG0336	Belongs to the RNA methyltransferase TrmD family
FY137_12775	COG0335	large ribosomal subunit rRNA binding
FY137_12780	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY137_12785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_12800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY137_12820	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY137_12840	COG0488	(ABC) transporter
FY137_12850	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY137_12860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY137_12865	COG0142	geranyltranstransferase activity
FY137_12870	COG2885	chlorophyll binding
FY137_12875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY137_12880	COG2223	nitrite transmembrane transporter activity
FY137_12885	COG1349	DNA-binding transcription factor activity
FY137_12890	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY137_12895	COG2197	response regulator
FY137_12900	COG1132	(ABC) transporter
FY137_12910	COG3459	Glycosyltransferase 36 associated
FY137_12915	COG1473	amidohydrolase
FY137_12920	COG0579	oxidoreductase
FY137_12930	COG0129	dihydroxy-acid dehydratase activity
FY137_12935	COG2084	Dehydrogenase
FY137_12940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_12945	COG0277	FAD linked oxidase domain protein
FY137_12950	COG2186	Transcriptional regulator
FY137_12960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY137_12965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_12970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_12975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY137_12985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY137_12990	COG0495	leucyl-tRNA aminoacylation
FY137_13005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY137_13010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY137_13020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY137_13025	COG1946	Acyl-CoA thioesterase
FY137_13030	COG0347	Belongs to the P(II) protein family
FY137_13035	COG0004	ammonium transporteR
FY137_13040	COG1674	ftsk spoiiie
FY137_13045	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY137_13060	COG0745	RESPONSE REGULATOR receiver
FY137_13070	COG1329	Transcriptional regulator
FY137_13080	COG2270	Major facilitator Superfamily
FY137_13095	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_13110	COG0494	nUDIX hydrolase
FY137_13115	COG2861	carbohydrate metabolic process
FY137_13120	COG0793	Belongs to the peptidase S41A family
FY137_13130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY137_13135	COG0799	negative regulation of ribosome biogenesis
FY137_13140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY137_13145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY137_13150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY137_13155	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY137_13170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY137_13175	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY137_13190	COG2301	Belongs to the HpcH HpaI aldolase family
FY137_13200	COG0066	3-isopropylmalate dehydratase activity
FY137_13205	COG0473	3-isopropylmalate dehydrogenase activity
FY137_13210	COG1858	cytochrome C peroxidase
FY137_13215	COG1797	cobyrinic acid a,c-diamide synthase activity
FY137_13225	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY137_13290	COG1492	cobalamin metabolic process
FY137_13305	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_13310	COG3254	rhamnose metabolic process
FY137_13315	COG0246	Mannitol dehydrogenase
FY137_13320	COG1063	alcohol dehydrogenase
FY137_13340	COG4214	carbohydrate transport
FY137_13345	COG1129	ABC transporter
FY137_13350	COG2186	Transcriptional regulator
FY137_13355	COG2721	sulfolactate sulfo-lyase activity
FY137_13360	COG0138	bifunctional purine biosynthesis protein purh
FY137_13370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY137_13370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY137_13375	COG0501	Belongs to the peptidase M48B family
FY137_13395	COG0357	Ribosomal RNA small subunit methyltransferase G
FY137_13400	COG0445	tRNA wobble uridine modification
FY137_13405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY137_13410	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY137_13415	COG1981	membrane
FY137_13420	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY137_13425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY137_13430	COG0424	maF-like protein
FY137_13435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY137_13440	COG0237	dephospho-CoA kinase activity
FY137_13450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY137_13455	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY137_13465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY137_13490	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY137_13505	COG0135	phosphoribosylanthranilate isomerase activity
FY137_13510	COG0133	tryptophan synthase activity
FY137_13515	COG0159	tryptophan synthase activity
FY137_13520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY137_13535	COG1074	ATP-dependent DNA helicase activity
FY137_13545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY137_13555	COG2205	protein histidine kinase activity
FY137_13560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY137_13565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY137_13570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY137_13570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY137_13575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY137_13580	COG0642	Histidine kinase
FY137_13585	COG0745	RESPONSE REGULATOR receiver
FY137_13590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY137_13600	COG1652	LysM domain
FY137_13605	COG1072	(Pantothenic acid kinase))
FY137_13610	COG0140	phosphoribosyl-ATP diphosphatase activity
FY137_13615	COG0107	imidazoleglycerol-phosphate synthase activity
FY137_13620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY137_13625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY137_13635	COG0131	Imidazoleglycerol-phosphate dehydratase
FY137_13640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY137_13645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY137_13655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY137_13670	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY137_13680	COG1643	Atp-dependent helicase
FY137_13720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY137_13735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY137_13745	COG2986	histidine ammonia-lyase
FY137_13750	COG0514	ATP-dependent DNA helicase (RecQ)
FY137_13775	COG1072	(Pantothenic acid kinase))
FY137_13780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY137_13785	COG1780	Probably involved in ribonucleotide reductase function
FY137_13805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY137_13835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_13845	COG2813	Specifically methylates the guanine in position
FY137_13850	COG1185	polyribonucleotide nucleotidyltransferase activity
FY137_13855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY137_13860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY137_13865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY137_13870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY137_13870	COG3064	Membrane
FY137_13885	COG0779	Required for maturation of 30S ribosomal subunits
FY137_13890	COG2814	Major facilitator Superfamily
FY137_13900	COG2951	lytic endotransglycosylase activity
FY137_13905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY137_13915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY137_13920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY137_13935	COG2816	NAD+ diphosphatase activity
FY137_13940	COG1605	Chorismate mutase
FY137_13940	COG0077	Prephenate dehydratase
FY137_13945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY137_13950	COG3474	cytochrome
FY137_13960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY137_13965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY137_13970	COG1278	Cold shock
FY137_13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY137_13985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY137_13985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY137_13995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY137_14025	COG2900	Belongs to the SlyX family
FY137_14035	COG0484	heat shock protein binding
FY137_14040	COG0443	Heat shock 70 kDa protein
FY137_14055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY137_14060	COG1744	ABC transporter substrate-binding protein PnrA-like
FY137_14065	COG3845	ABC transporter
FY137_14070	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY137_14075	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY137_14080	COG0295	cytidine deaminase activity
FY137_14085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FY137_14090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY137_14095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY137_14105	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY137_14110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY137_14115	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY137_14125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY137_14130	COG1845	cytochrome c oxidase, subunit III
FY137_14135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY137_14145	COG0477	Major facilitator Superfamily
FY137_14150	COG0067	glutamate synthase
FY137_14150	COG0069	glutamate synthase activity
FY137_14150	COG0070	glutamate synthase
FY137_14155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY137_14170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY137_14180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY137_14210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_14230	COG0848	biopolymer transport protein
FY137_14240	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY137_14255	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY137_14260	COG3454	Phosphonate metabolism
FY137_14265	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY137_14270	COG3639	organic phosphonate transmembrane transporter activity
FY137_14280	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FY137_14285	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY137_14295	COG4778	phosphonate C-P lyase system protein PhnL
FY137_14300	COG4107	phosphonate C-P lyase system protein PhnK
FY137_14305	COG3627	carbon phosphorus lyase activity
FY137_14310	COG3626	phosphonate metabolism
FY137_14315	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY137_14320	COG3624	Phosphonate C-P lyase system protein PhnG
FY137_14325	COG2188	Transcriptional regulator
FY137_14330	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY137_14335	COG0837	glucose binding
FY137_14340	COG1803	Methylglyoxal synthase
FY137_14345	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY137_14350	COG4166	transmembrane transport
FY137_14355	COG4174	ABC transporter (Permease)
FY137_14360	COG4239	(ABC) transporter, permease
FY137_14365	COG4172	Belongs to the ABC transporter superfamily
FY137_14370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_14375	COG0174	glutamine synthetase
FY137_14380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_14385	COG3265	gluconokinase activity
FY137_14390	COG1174	glycine betaine transport
FY137_14395	COG1125	glycine betaine transport
FY137_14400	COG1174	glycine betaine transport
FY137_14405	COG1732	Glycine betaine
FY137_14415	COG1959	2 iron, 2 sulfur cluster binding
FY137_14420	COG1840	ABC-type Fe3 transport system, periplasmic component
FY137_14430	COG4269	membrane
FY137_14445	COG0697	spore germination
FY137_14460	COG0791	NLP P60 protein
FY137_14470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY137_14475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY137_14510	COG4964	Belongs to the GSP D family
FY137_14555	COG3422	double-strand break repair
FY137_14560	COG3757	hydrolase, family 25
FY137_14565	COG0697	spore germination
FY137_14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY137_14595	COG0481	GTPase activity
FY137_14600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY137_14615	COG1396	sequence-specific DNA binding
FY137_14630	COG1917	Cupin 2, conserved barrel domain protein
FY137_14630	COG2169	Transcriptional regulator
FY137_14635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY137_14660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY137_14665	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY137_14670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY137_14680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY137_14685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY137_14685	COG0072	phenylalanine-tRNA ligase activity
FY137_14690	COG0667	Aldo Keto reductase
FY137_14710	COG4977	sequence-specific DNA binding
FY137_14735	COG1570	exodeoxyribonuclease VII activity
FY137_14740	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_14750	COG1846	Transcriptional regulator
FY137_14755	COG0697	spore germination
FY137_14760	COG2309	aminopeptidase activity
FY137_14770	COG1393	Belongs to the ArsC family
FY137_14795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY137_14795	COG0519	Catalyzes the synthesis of GMP from XMP
FY137_14810	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY137_14840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY137_14850	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY137_14860	COG1968	undecaprenyl-diphosphatase activity
FY137_14875	COG0284	orotidine-5'-phosphate decarboxylase activity
FY137_14885	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY137_14895	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY137_14900	COG0792	nuclease activity
FY137_14915	COG1175	transmembrane transport
FY137_14925	COG3842	ATPase activity
FY137_14935	COG0189	ligase activity
FY137_14940	COG0606	chelatase, subunit chli
FY137_14945	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY137_14950	COG1280	lysine exporter protein (LysE YggA)
FY137_14955	COG0756	dUTP diphosphatase activity
FY137_14960	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY137_14965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY137_14980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY137_14985	COG2226	methyltransferase
FY137_14990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY137_14995	COG1024	Enoyl-CoA hydratase
FY137_15000	COG0268	Binds directly to 16S ribosomal RNA
FY137_15010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY137_15070	COG0395	ABC-type sugar transport system, permease component
FY137_15075	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_15085	COG3842	ATPase activity
FY137_15120	COG1653	transport
FY137_15135	COG3842	ATPase activity
FY137_15155	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_15160	COG3842	ATPase activity
FY137_15180	COG2072	flavoprotein involved in K transport
FY137_15190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_15195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_15200	COG1116	anion transmembrane transporter activity
FY137_15210	COG2271	Major facilitator Superfamily
FY137_15215	COG1473	amidohydrolase
FY137_15220	COG0395	ABC-type sugar transport system, permease component
FY137_15225	COG1175	transmembrane transport
FY137_15255	COG1609	Transcriptional regulator
FY137_15270	COG1082	Xylose isomerase domain protein TIM barrel
FY137_15285	COG3842	ATPase activity
FY137_15290	COG0395	ABC-type sugar transport system, permease component
FY137_15295	COG1175	transmembrane transport
FY137_15300	COG1653	transport
FY137_15305	COG1309	transcriptional regulator
FY137_15310	COG0673	inositol 2-dehydrogenase activity
FY137_15325	COG0673	inositol 2-dehydrogenase activity
FY137_15330	COG1278	Cold shock
FY137_15350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY137_15355	COG0577	efflux transmembrane transporter activity
FY137_15355	COG1136	(ABC) transporter
FY137_15360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_15385	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY137_15400	COG3842	ATPase activity
FY137_15405	COG0395	ABC-type sugar transport system, permease component
FY137_15410	COG1175	transmembrane transport
FY137_15420	COG3618	amidohydrolase
FY137_15425	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_15430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_15435	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_15440	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY137_15445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_15450	COG2186	Transcriptional regulator
FY137_15495	COG4977	sequence-specific DNA binding
FY137_15500	COG2223	nitrite transmembrane transporter activity
FY137_15505	COG0583	DNA-binding transcription factor activity
FY137_15510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_15520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_15525	COG2084	Dehydrogenase
FY137_15540	COG1609	Transcriptional regulator
FY137_15545	COG1063	alcohol dehydrogenase
FY137_15550	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_15560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_15565	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY137_15570	COG1175	transmembrane transport
FY137_15575	COG0395	ABC-type sugar transport system, permease component
FY137_15590	COG0395	ABC-type sugar transport system, permease component
FY137_15595	COG1175	transmembrane transport
FY137_15600	COG2182	Extracellular solute-binding protein
FY137_15605	COG0626	cystathionine gamma-synthase activity
FY137_15620	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY137_15630	COG1121	(ABC) transporter
FY137_15635	COG0523	cobalamin synthesis protein
FY137_15650	COG0523	cobalamin synthesis protein
FY137_15655	COG1653	transport
FY137_15660	COG1175	transmembrane transport
FY137_15665	COG0395	ABC-type sugar transport system, permease component
FY137_15670	COG3842	ATPase activity
FY137_15680	COG3047	cAMP biosynthetic process
FY137_15710	COG0583	DNA-binding transcription factor activity
FY137_15715	COG1879	ABC-type sugar transport system periplasmic component
FY137_15720	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_15725	COG1129	ABC transporter
FY137_15735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY137_15740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_15750	COG3257	ureidoglycine aminohydrolase activity
FY137_15760	COG5001	Diguanylate cyclase
FY137_15765	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY137_15775	COG0747	negative chemotaxis
FY137_15780	COG0601	transmembrane transport
FY137_15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_15790	COG0444	Belongs to the ABC transporter superfamily
FY137_15795	COG4608	Belongs to the ABC transporter superfamily
FY137_15800	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY137_15815	COG0346	lactoylglutathione lyase activity
FY137_15825	COG0129	dihydroxy-acid dehydratase activity
FY137_15830	COG1879	ABC-type sugar transport system periplasmic component
FY137_15835	COG1129	ABC transporter
FY137_15840	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_15845	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_15850	COG2186	Transcriptional regulator
FY137_15870	COG0587	DNA-directed DNA polymerase activity
FY137_15900	COG0673	inositol 2-dehydrogenase activity
FY137_15910	COG3842	ATPase activity
FY137_15915	COG0395	ABC-type sugar transport system, permease component
FY137_15920	COG1175	transmembrane transport
FY137_15925	COG1653	transport
FY137_15935	COG0673	inositol 2-dehydrogenase activity
FY137_15950	COG5001	Diguanylate cyclase
FY137_15965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY137_15970	COG2894	cell division
FY137_15975	COG0850	regulation of cytokinetic process
FY137_15980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY137_15995	COG2186	Transcriptional regulator
FY137_16000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_16010	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_16015	COG1063	alcohol dehydrogenase
FY137_16020	COG1312	Catalyzes the dehydration of D-mannonate
FY137_16040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_16045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY137_16045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_16050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_16065	COG0625	glutathione transferase activity
FY137_16070	COG4172	Belongs to the ABC transporter superfamily
FY137_16075	COG1921	L-seryl-tRNASec selenium transferase activity
FY137_16090	COG3964	amidohydrolase
FY137_16100	COG0601	transmembrane transport
FY137_16105	COG0747	negative chemotaxis
FY137_16110	COG0438	transferase activity, transferring glycosyl groups
FY137_16145	COG4989	oxidoreductase activity
FY137_16160	COG3842	ATPase activity
FY137_16165	COG1653	transport
FY137_16170	COG1175	transmembrane transport
FY137_16175	COG0395	ABC-type sugar transport system, permease component
FY137_16180	COG1501	Belongs to the glycosyl hydrolase 31 family
FY137_16210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_16215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_16220	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY137_16225	COG0352	thiamine-phosphate diphosphorylase activity
FY137_16230	COG0351	phosphomethylpyrimidine kinase
FY137_16235	COG1522	sequence-specific DNA binding
FY137_16240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY137_16245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_16260	COG2204	response regulator
FY137_16265	COG4191	Histidine kinase
FY137_16270	COG1301	dicarboxylic acid transport
FY137_16280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY137_16285	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_16295	COG1473	amidohydrolase
FY137_16315	COG1215	transferase activity, transferring glycosyl groups
FY137_16325	COG2942	2-epimerase
FY137_16350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_16360	COG2197	response regulator
FY137_16390	COG3307	-O-antigen
FY137_16395	COG1596	polysaccharide export
FY137_16400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY137_16410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY137_16415	COG1376	ErfK ybiS ycfS ynhG family protein
FY137_16425	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_16435	COG2094	Belongs to the DNA glycosylase MPG family
FY137_16450	COG1609	Transcriptional regulator
FY137_16455	COG1653	transport
FY137_16480	COG0673	inositol 2-dehydrogenase activity
FY137_16485	COG0602	queuosine metabolic process
FY137_16490	COG0720	synthase
FY137_16495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY137_16500	COG0673	inositol 2-dehydrogenase activity
FY137_16515	COG0395	ABC-type sugar transport system, permease component
FY137_16520	COG1175	transmembrane transport
FY137_16545	COG0583	DNA-binding transcription factor activity
FY137_16550	COG0280	phosphate acetyltransferase
FY137_16550	COG0281	malic enzyme
FY137_16565	COG0765	amino acid transport
FY137_16570	COG1126	abc transporter atp-binding protein
FY137_16575	COG2079	MmgE PrpD family protein
FY137_16580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_16590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_16605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY137_16615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY137_16620	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY137_16625	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_16630	COG1129	ABC transporter
FY137_16640	COG1473	amidohydrolase
FY137_16660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_16665	COG0601	transmembrane transport
FY137_16670	COG0583	DNA-binding transcription factor activity
FY137_16675	COG1446	asparaginase
FY137_16690	COG0747	negative chemotaxis
FY137_16710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_16715	COG0601	transmembrane transport
FY137_16720	COG2197	response regulator
FY137_16725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_16730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_16745	COG0395	ABC-type sugar transport system, permease component
FY137_16750	COG1175	transmembrane transport
FY137_16760	COG0673	inositol 2-dehydrogenase activity
FY137_16765	COG0673	inositol 2-dehydrogenase activity
FY137_16785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_16790	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY137_16810	COG1595	DNA-templated transcription, initiation
FY137_16815	COG1120	ATPase activity
FY137_16820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_16835	COG2226	methyltransferase
FY137_16845	COG1120	ATPase activity
FY137_16850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_16870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY137_16895	COG1012	belongs to the aldehyde dehydrogenase family
FY137_16900	COG0473	3-isopropylmalate dehydrogenase activity
FY137_16905	COG1012	belongs to the aldehyde dehydrogenase family
FY137_16915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_16955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_16960	COG4172	Belongs to the ABC transporter superfamily
FY137_16965	COG1522	sequence-specific DNA binding
FY137_16975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_16990	COG0583	DNA-binding transcription factor activity
FY137_17000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_17005	COG1126	abc transporter atp-binding protein
FY137_17015	COG1473	amidohydrolase
FY137_17020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17030	COG1959	2 iron, 2 sulfur cluster binding
FY137_17040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY137_17045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17075	COG1960	acyl-CoA dehydrogenase activity
FY137_17100	COG0444	Belongs to the ABC transporter superfamily
FY137_17110	COG0667	Aldo Keto reductase
FY137_17120	COG0583	DNA-binding transcription factor activity
FY137_17125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17130	COG4166	transmembrane transport
FY137_17140	COG0747	negative chemotaxis
FY137_17145	COG1473	amidohydrolase
FY137_17150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17155	COG0702	epimerase
FY137_17165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_17190	COG4608	Belongs to the ABC transporter superfamily
FY137_17195	COG0444	Belongs to the ABC transporter superfamily
FY137_17205	COG0601	transmembrane transport
FY137_17215	COG2186	Transcriptional regulator
FY137_17230	COG0300	oxidoreductase activity
FY137_17240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY137_17240	COG3453	Protein conserved in bacteria
FY137_17245	COG0640	Transcriptional regulator
FY137_17255	COG2391	methyltransferase activity
FY137_17260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY137_17270	COG0022	dehydrogenase e1 component
FY137_17280	COG1960	acyl-CoA dehydrogenase activity
FY137_17285	COG0183	Belongs to the thiolase family
FY137_17295	COG1960	acyl-CoA dehydrogenase activity
FY137_17300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY137_17320	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY137_17325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY137_17330	COG4952	isomerase
FY137_17335	COG3347	Dehydrogenase
FY137_17335	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_17340	COG1349	DNA-binding transcription factor activity
FY137_17350	COG1129	ABC transporter
FY137_17355	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_17360	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_17365	COG3254	rhamnose metabolic process
FY137_17380	COG2264	protein methyltransferase activity
FY137_17385	COG5001	Diguanylate cyclase
FY137_17400	COG4335	DNA alkylation repair
FY137_17405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY137_17410	COG4208	sulfate ABC transporter
FY137_17425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY137_17440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY137_17450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY137_17460	COG1040	competence protein
FY137_17465	COG2226	methyltransferase
FY137_17480	COG0494	nUDIX hydrolase
FY137_17490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY137_17495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY137_17500	COG0653	protein targeting
FY137_17505	COG0697	spore germination
FY137_17580	COG2244	polysaccharide biosynthetic process
FY137_17595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY137_17605	COG3206	protein involved in exopolysaccharide biosynthesis
FY137_17605	COG0489	protein tyrosine kinase activity
FY137_17625	COG0438	transferase activity, transferring glycosyl groups
FY137_17630	COG0438	transferase activity, transferring glycosyl groups
FY137_17645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY137_17650	COG2273	Hydrolase Family 16
FY137_17650	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY137_17695	COG1396	sequence-specific DNA binding
FY137_17705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY137_17710	COG1129	ABC transporter
FY137_17715	COG4214	carbohydrate transport
FY137_17720	COG4213	ABC transporter substrate-binding protein
FY137_17735	COG0346	lactoylglutathione lyase activity
FY137_17740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY137_17740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY137_17745	COG4770	biotin carboxylase activity
FY137_17760	COG0625	glutathione transferase activity
FY137_17765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY137_17770	COG1396	sequence-specific DNA binding
FY137_17770	COG3800	Transcriptional regulator
FY137_17780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY137_17790	COG0300	oxidoreductase activity
FY137_17800	COG2096	Adenosyltransferase
FY137_17810	COG2086	electron transfer activity
FY137_17820	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY137_17830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY137_17835	COG0165	Argininosuccinate lyase
FY137_17870	COG2884	Cell division ATP-binding protein ftsE
FY137_17890	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY137_17905	COG0287	Prephenate dehydrogenase
FY137_17910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY137_17915	COG2226	methyltransferase
FY137_17920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY137_17935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY137_17940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY137_17975	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY137_17980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY137_17990	COG4974	Belongs to the 'phage' integrase family
FY137_17995	COG0825	malonyl-CoA metabolic process
FY137_18000	COG3034	peptidoglycan biosynthetic process
FY137_18005	COG0425	Belongs to the sulfur carrier protein TusA family
FY137_18005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY137_18010	COG0523	cobalamin synthesis protein
FY137_18015	COG1686	Belongs to the peptidase S11 family
FY137_18020	COG1473	amidohydrolase
FY137_18030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FY137_18035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY137_18045	COG2706	6-phosphogluconolactonase activity
FY137_18070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FY137_18105	COG0673	inositol 2-dehydrogenase activity
FY137_18115	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_18125	COG3962	Belongs to the TPP enzyme family
FY137_18130	COG0673	inositol 2-dehydrogenase activity
FY137_18135	COG1012	belongs to the aldehyde dehydrogenase family
FY137_18145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY137_18165	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_18170	COG1129	ABC transporter
FY137_18180	COG4953	penicillin-binding protein 1C
FY137_18185	COG2373	Large extracellular alpha-helical protein
FY137_18190	COG2835	tetraacyldisaccharide 4'-kinase activity
FY137_18415	COG0482	sulfurtransferase activity
FY137_18430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY137_18445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY137_18450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY137_18455	COG0037	tRNA processing
FY137_18465	COG2885	chlorophyll binding
FY137_18470	COG0823	Involved in the tonB-independent uptake of proteins
FY137_18490	COG0824	Thioesterase
FY137_18500	COG0494	nUDIX hydrolase
FY137_18515	COG2255	four-way junction helicase activity
FY137_18530	COG0632	four-way junction helicase activity
FY137_18535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY137_18540	COG0840	transmembrane signaling receptor activity
FY137_18545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_18550	COG0217	transcriptional regulatory protein
FY137_18565	COG1692	metallophosphoesterase
FY137_18575	COG1253	flavin adenine dinucleotide binding
FY137_18615	COG0126	phosphoglycerate kinase activity
FY137_18620	COG3588	fructose-bisphosphate aldolase
FY137_18630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY137_18640	COG1414	Transcriptional regulator
FY137_18655	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_18695	COG0254	rRNA binding
FY137_18700	COG1132	(ABC) transporter
FY137_18725	COG0483	inositol monophosphate 1-phosphatase activity
FY137_18755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY137_18760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY137_18765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY137_18770	COG0457	Tetratricopeptide repeat
FY137_18800	COG3750	Belongs to the UPF0335 family
FY137_18825	COG0469	pyruvate kinase activity
FY137_18830	COG3108	Peptidase M15
FY137_18835	COG2204	response regulator
FY137_18840	COG1164	Oligoendopeptidase f
FY137_18845	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY137_18855	COG5310	Homospermidine synthase
FY137_18865	COG0737	Belongs to the 5'-nucleotidase family
FY137_18870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY137_18875	COG0330	HflC and HflK could
FY137_18900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY137_18905	COG2951	lytic endotransglycosylase activity
FY137_18920	COG2205	protein histidine kinase activity
FY137_18935	COG0067	glutamate synthase
FY137_18935	COG0069	glutamate synthase activity
FY137_18935	COG0070	glutamate synthase
FY137_18950	COG2205	protein histidine kinase activity
FY137_18955	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY137_18960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY137_18965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY137_18975	COG0252	asparaginase activity
FY137_18985	COG1027	Aspartate ammonia-lyase
FY137_18990	COG2186	Transcriptional regulator
FY137_19020	COG3842	ATPase activity
FY137_19025	COG0395	ABC-type sugar transport system, permease component
FY137_19045	COG1012	belongs to the aldehyde dehydrogenase family
FY137_19050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_19060	COG2267	carboxylic ester hydrolase activity
FY137_19085	COG4176	ABC-type proline glycine betaine transport system permease component
FY137_19090	COG4175	Glycine betaine
FY137_19090	COG0517	IMP dehydrogenase activity
FY137_19095	COG2986	histidine ammonia-lyase
FY137_19110	COG0174	glutamine synthetase
FY137_19115	COG0069	glutamate synthase activity
FY137_19120	COG2218	PFAM glutamate synthase alpha subunit domain protein
FY137_19125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY137_19135	COG4977	sequence-specific DNA binding
FY137_19140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_19145	COG4311	Sarcosine oxidase, delta subunit
FY137_19150	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY137_19150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_19160	COG1609	Transcriptional regulator
FY137_19180	COG1082	Xylose isomerase domain protein TIM barrel
FY137_19185	COG0673	inositol 2-dehydrogenase activity
FY137_19190	COG1082	Xylose isomerase domain protein TIM barrel
FY137_19195	COG1082	Xylose isomerase domain protein TIM barrel
FY137_19200	COG2957	Belongs to the agmatine deiminase family
FY137_19225	COG0270	DNA (cytosine-5-)-methyltransferase activity
FY137_19240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY137_19280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_19290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_19295	COG0601	transmembrane transport
FY137_19300	COG0747	negative chemotaxis
FY137_19310	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY137_19315	COG1454	alcohol dehydrogenase
FY137_19355	COG2307	Protein conserved in bacteria
FY137_19355	COG2308	Evidence 4 Homologs of previously reported genes of
FY137_19370	COG0488	(ABC) transporter
FY137_19375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY137_19380	COG2186	Transcriptional regulator
FY137_19395	COG1175	transmembrane transport
FY137_19400	COG0395	ABC-type sugar transport system, permease component
FY137_19410	COG3842	ATPase activity
FY137_19430	COG0110	maltose O-acetyltransferase activity
FY137_19435	COG1304	FMN binding
FY137_19450	COG1063	alcohol dehydrogenase
FY137_19455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_19460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_19470	COG0765	amino acid transport
FY137_19475	COG0765	amino acid transport
FY137_19480	COG4221	oxidoreductase activity
FY137_19485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY137_19490	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_19495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_19510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_19525	COG0697	spore germination
FY137_19530	COG0697	spore germination
FY137_19535	COG0511	ligase activity, forming carbon-carbon bonds
FY137_19540	COG0439	Biotin carboxylase
FY137_19550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY137_19555	COG1984	allophanate hydrolase subunit 2
FY137_19560	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY137_19565	COG3842	ATPase activity
FY137_19575	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY137_19585	COG0436	Aminotransferase
FY137_19590	COG4221	oxidoreductase activity
FY137_19605	COG1070	Carbohydrate kinase
FY137_19610	COG1830	Aldolase
FY137_19615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY137_19620	COG0667	Aldo Keto reductase
FY137_19630	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_19635	COG1129	ABC transporter
FY137_19640	COG1879	ABC-type sugar transport system periplasmic component
FY137_19645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY137_19655	COG1609	Transcriptional regulator
FY137_19660	COG1053	succinate dehydrogenase
FY137_19660	COG3976	FMN-binding domain protein
FY137_19670	COG1175	transmembrane transport
FY137_19675	COG0395	ABC-type sugar transport system, permease component
FY137_19680	COG3842	ATPase activity
FY137_19685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FY137_19700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_19715	COG0601	transmembrane transport
FY137_19720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_19725	COG4172	Belongs to the ABC transporter superfamily
FY137_19730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_19735	COG4172	Belongs to the ABC transporter superfamily
FY137_19740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_19745	COG0601	transmembrane transport
FY137_19750	COG4166	transmembrane transport
FY137_19780	COG0071	Belongs to the small heat shock protein (HSP20) family
FY137_19795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY137_19810	COG0395	ABC-type sugar transport system, permease component
FY137_19825	COG3842	ATPase activity
FY137_19850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_19870	COG1129	ABC transporter
FY137_19875	COG4214	carbohydrate transport
FY137_19880	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY137_19930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY137_19930	COG1648	precorrin-2 dehydrogenase activity
FY137_19935	COG0243	molybdopterin cofactor binding
FY137_19945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY137_19950	COG1116	anion transmembrane transporter activity
FY137_19955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_19960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_19965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_19970	COG3707	response regulator
FY137_19975	COG1802	Transcriptional regulator
FY137_19980	COG1914	H( )-stimulated, divalent metal cation uptake system
FY137_19985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY137_19990	COG4336	lyase activity
FY137_19995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY137_20000	COG4770	biotin carboxylase activity
FY137_20005	COG0366	Alpha amylase catalytic
FY137_20015	COG4771	TonB-dependent receptor
FY137_20020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY137_20040	COG1414	Transcriptional regulator
FY137_20045	COG1475	DNA binding
FY137_20050	COG1192	Involved in chromosome partitioning
FY137_20080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY137_20090	COG2986	histidine ammonia-lyase
FY137_20095	COG1228	amidohydrolase
FY137_20100	COG0402	S-adenosylhomocysteine deaminase activity
FY137_20175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY137_20180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY137_20195	COG4774	siderophore transport
FY137_20200	COG1309	transcriptional regulator
FY137_20230	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FY137_20235	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_20250	COG1609	Transcriptional regulator
FY137_20260	COG1929	Belongs to the glycerate kinase type-1 family
FY137_20300	COG0601	transmembrane transport
FY137_20305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_20310	COG2226	methyltransferase
FY137_20315	COG1120	ATPase activity
FY137_20320	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_20325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_20330	COG4592	Periplasmic binding protein
FY137_20380	COG1120	ATPase activity
FY137_20385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_20390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_20395	COG4607	ABC-type enterochelin transport system periplasmic component
FY137_20400	COG1629	transport
FY137_20400	COG4774	siderophore transport
FY137_20410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FY137_20455	COG2226	methyltransferase
FY137_20465	COG0318	PFAM AMP-dependent synthetase and ligase
FY137_20485	COG0534	Mate efflux family protein
FY137_20495	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FY137_20500	COG1959	2 iron, 2 sulfur cluster binding
FY137_20515	COG1609	Transcriptional regulator
FY137_20525	COG4211	Belongs to the binding-protein-dependent transport system permease family
FY137_20545	COG1737	Transcriptional regulator
FY137_20555	COG1309	transcriptional regulator
FY137_20560	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_20585	COG1846	Transcriptional regulator
FY137_20590	COG0583	DNA-binding transcription factor activity
FY137_20595	COG2828	Protein conserved in bacteria
FY137_20610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_20630	COG0840	transmembrane signaling receptor activity
FY137_20635	COG0431	NADPH-dependent FMN reductase
FY137_20665	COG1215	transferase activity, transferring glycosyl groups
FY137_20700	COG0583	DNA-binding transcription factor activity
FY137_20705	COG0346	lactoylglutathione lyase activity
FY137_20720	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY137_20745	COG1309	transcriptional regulator
FY137_20750	COG2268	Band 7 protein
FY137_20760	COG1842	Phage shock protein A
FY137_20770	COG0583	DNA-binding transcription factor activity
FY137_20775	COG0477	Major facilitator Superfamily
FY137_20795	COG4774	siderophore transport
FY137_20815	COG2205	protein histidine kinase activity
FY137_20820	COG0745	RESPONSE REGULATOR receiver
FY137_20825	COG0671	phosphoesterase, PA-phosphatase related
FY137_20875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY137_20885	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY137_20890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY137_20895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY137_20910	COG0010	Belongs to the arginase family
FY137_20920	COG0697	spore germination
FY137_20925	COG0673	inositol 2-dehydrogenase activity
FY137_20950	COG0477	Major facilitator Superfamily
FY137_20965	COG2194	sulfuric ester hydrolase activity
FY137_20975	COG0583	DNA-binding transcription factor activity
FY137_20980	COG4774	siderophore transport
FY137_20995	COG1120	ATPase activity
FY137_21010	COG2137	regulation of response to DNA damage stimulus
FY137_21015	COG3386	PFAM SMP-30 Gluconolaconase
FY137_21025	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_21030	COG1129	ABC transporter
FY137_21035	COG1879	ABC-type sugar transport system periplasmic component
FY137_21040	COG4585	Histidine kinase
FY137_21045	COG2197	response regulator
FY137_21055	COG2133	pyrroloquinoline quinone binding
FY137_21065	COG0500	methyltransferase
FY137_21070	COG0564	pseudouridine synthase activity
FY137_21080	COG0492	ferredoxin-NADP+ reductase activity
FY137_21085	COG3448	diguanylate cyclase activity
FY137_21085	COG4175	Glycine betaine
FY137_21090	COG4176	ABC-type proline glycine betaine transport system permease component
FY137_21100	COG4191	Histidine kinase
FY137_21100	COG0784	Response regulator, receiver
FY137_21110	COG3206	protein involved in exopolysaccharide biosynthesis
FY137_21110	COG0489	protein tyrosine kinase activity
FY137_21115	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY137_21120	COG1215	transferase activity, transferring glycosyl groups
FY137_21125	COG1215	transferase activity, transferring glycosyl groups
FY137_21130	COG1215	transferase activity, transferring glycosyl groups
FY137_21135	COG0438	transferase activity, transferring glycosyl groups
FY137_21140	COG2273	Hydrolase Family 16
FY137_21145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY137_21150	COG2244	polysaccharide biosynthetic process
FY137_21155	COG0463	Glycosyl transferase, family 2
FY137_21160	COG2327	Polysaccharide pyruvyl transferase
FY137_21165	COG1215	transferase activity, transferring glycosyl groups
FY137_21185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY137_21190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_21205	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY137_21205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_21230	COG0033	Phosphoglucomutase
FY137_21235	COG0297	glycogen (starch) synthase activity
FY137_21240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY137_21245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY137_21250	COG0058	SHG alpha-glucan phosphorylase activity
FY137_21260	COG1794	racemase activity, acting on amino acids and derivatives
FY137_21265	COG1522	sequence-specific DNA binding
FY137_21275	COG2084	Dehydrogenase
FY137_21280	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_21285	COG1063	alcohol dehydrogenase
FY137_21295	COG4988	ABC transporter
FY137_21300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY137_21310	COG1294	oxidase, subunit
FY137_21340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY137_21345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY137_21375	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY137_21380	COG0539	negative regulation of cytoplasmic translation
FY137_21410	COG4221	oxidoreductase activity
FY137_21415	COG0006	proline dipeptidase activity
FY137_21420	COG0747	negative chemotaxis
FY137_21425	COG0601	transmembrane transport
FY137_21430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_21435	COG0444	Belongs to the ABC transporter superfamily
FY137_21440	COG4608	Belongs to the ABC transporter superfamily
FY137_21445	COG0246	Mannitol dehydrogenase
FY137_21460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_21505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY137_21510	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_21525	COG4993	Dehydrogenase
FY137_21530	COG3685	Protein conserved in bacteria
FY137_21535	COG1285	pathogenesis
FY137_21560	COG0693	protein deglycase activity
FY137_21580	COG0189	ligase activity
FY137_21585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_21590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY137_21600	COG0435	Glutathione S-transferase
FY137_21605	COG0583	DNA-binding transcription factor activity
FY137_21610	COG1012	belongs to the aldehyde dehydrogenase family
FY137_21615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY137_21620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY137_21625	COG1116	anion transmembrane transporter activity
FY137_21635	COG1522	sequence-specific DNA binding
FY137_21650	COG0784	Response regulator, receiver
FY137_21660	COG3920	Histidine kinase
FY137_21670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY137_21685	COG0019	diaminopimelate decarboxylase activity
FY137_21695	COG1309	transcriptional regulator
FY137_21710	COG0527	aspartate kinase activity
FY137_21720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY137_21725	COG2890	protein-(glutamine-N5) methyltransferase activity
FY137_21735	COG0542	response to heat
FY137_21740	COG0741	lytic transglycosylase activity
FY137_21740	COG1196	nuclear chromosome segregation
FY137_21740	COG0739	heme binding
FY137_21785	COG0534	Mate efflux family protein
FY137_21800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY137_21805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY137_21815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_21825	COG0625	glutathione transferase activity
FY137_21830	COG0300	oxidoreductase activity
FY137_21840	COG3734	2-keto-3-deoxy-galactonokinase
FY137_21845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_21850	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_21860	COG1175	transmembrane transport
FY137_21865	COG0395	ABC-type sugar transport system, permease component
FY137_21870	COG3842	ATPase activity
FY137_21875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY137_21880	COG1414	Transcriptional regulator
FY137_21885	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_21900	COG4171	peptide transport system, permease
FY137_21960	COG0745	RESPONSE REGULATOR receiver
FY137_21970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_21975	COG1136	(ABC) transporter
FY137_21975	COG0577	efflux transmembrane transporter activity
FY137_21985	COG1733	regulation of RNA biosynthetic process
FY137_22000	COG0596	Alpha beta hydrolase
FY137_22030	COG1454	alcohol dehydrogenase
FY137_22040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY137_22075	COG0583	DNA-binding transcription factor activity
FY137_22080	COG3842	ATPase activity
FY137_22090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_22100	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_22105	COG4208	sulfate ABC transporter
FY137_22140	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY137_22160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY137_22180	COG2186	Transcriptional regulator
FY137_22185	COG0277	FAD linked oxidase domain protein
FY137_22185	COG0247	lactate metabolic process
FY137_22190	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_22195	COG4221	oxidoreductase activity
FY137_22205	COG0028	Belongs to the TPP enzyme family
FY137_22220	COG0436	Aminotransferase
FY137_22225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY137_22230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_22235	COG0583	DNA-binding transcription factor activity
FY137_22265	COG2086	electron transfer activity
FY137_22285	COG2376	Dihydroxyacetone kinase
FY137_22290	COG1522	sequence-specific DNA binding
FY137_22310	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY137_22315	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY137_22335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_22345	COG4172	Belongs to the ABC transporter superfamily
FY137_22350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_22360	COG0747	negative chemotaxis
FY137_22370	COG0277	FAD linked oxidase domain protein
FY137_22390	COG0778	Nitroreductase
FY137_22410	COG0583	DNA-binding transcription factor activity
FY137_22430	COG0395	ABC-type sugar transport system, permease component
FY137_22435	COG3842	ATPase activity
FY137_22445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_22450	COG1940	carbohydrate kinase activity
FY137_22450	COG1846	Transcriptional regulator
FY137_22460	COG3842	ATPase activity
FY137_22465	COG1177	transmembrane transport
FY137_22495	COG3842	ATPase activity
FY137_22505	COG1177	transmembrane transport
FY137_22510	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_22525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY137_22550	COG2318	DinB family
FY137_22555	COG0583	DNA-binding transcription factor activity
FY137_22570	COG1335	isochorismatase
FY137_22595	COG3842	ATPase activity
FY137_22600	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_22605	COG1177	transmembrane transport
FY137_22610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY137_22620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY137_22630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY137_22635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY137_22640	COG1845	cytochrome c oxidase, subunit III
FY137_22655	COG3938	Belongs to the proline racemase family
FY137_22660	COG4176	ABC-type proline glycine betaine transport system permease component
FY137_22665	COG4176	ABC-type proline glycine betaine transport system permease component
FY137_22670	COG4175	Glycine betaine
FY137_22670	COG3448	diguanylate cyclase activity
FY137_22680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_22685	COG1012	belongs to the aldehyde dehydrogenase family
FY137_22690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_22700	COG1917	Cupin 2, conserved barrel domain protein
FY137_22700	COG4977	sequence-specific DNA binding
FY137_22715	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY137_22715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_22725	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY137_22730	COG1760	l-serine dehydratase
FY137_22745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_22750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FY137_22755	COG4774	siderophore transport
FY137_22775	COG1309	transcriptional regulator
FY137_22785	COG1063	alcohol dehydrogenase
FY137_22795	COG1879	ABC-type sugar transport system periplasmic component
FY137_22805	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_22815	COG1069	ribulokinase activity
FY137_22945	COG5001	Diguanylate cyclase
FY137_22945	COG3300	MHYT domain
FY137_22950	COG0483	inositol monophosphate 1-phosphatase activity
FY137_22980	COG1178	ABC-type Fe3 transport system permease component
FY137_22985	COG3842	ATPase activity
FY137_23005	COG0483	inositol monophosphate 1-phosphatase activity
FY137_23020	COG3842	ATPase activity
FY137_23025	COG0395	ABC-type sugar transport system, permease component
FY137_23030	COG1175	transmembrane transport
FY137_23045	COG0673	inositol 2-dehydrogenase activity
FY137_23050	COG1609	Transcriptional regulator
FY137_23065	COG0583	DNA-binding transcription factor activity
FY137_23070	COG2423	ornithine cyclodeaminase activity
FY137_23075	COG0251	oxidation-reduction process
FY137_23080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_23085	COG0477	Major facilitator Superfamily
FY137_23095	COG0583	DNA-binding transcription factor activity
FY137_23105	COG1879	ABC-type sugar transport system periplasmic component
FY137_23110	COG1129	ABC transporter
FY137_23115	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_23125	COG1609	Transcriptional regulator
FY137_23135	COG0673	inositol 2-dehydrogenase activity
FY137_23195	COG0714	Associated with various cellular activities
FY137_23200	COG3256	nitric oxide reductase
FY137_23215	COG1845	cytochrome c oxidase, subunit III
FY137_23225	COG0163	prenyltransferase activity
FY137_23230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY137_23235	COG3189	MarR family transcriptional regulator
FY137_23245	COG0826	peptidase U32
FY137_23280	COG4459	periplasmic nitrate reductase
FY137_23295	COG0243	molybdopterin cofactor binding
FY137_23305	COG3005	denitrification pathway
FY137_23320	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_23325	COG3433	isochorismatase activity
FY137_23325	COG1535	isochorismatase
FY137_23330	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY137_23335	COG1169	isochorismate synthase
FY137_23345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY137_23345	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY137_23350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY137_23360	COG2375	cellular response to nickel ion
FY137_23370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_23375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_23380	COG1120	ATPase activity
FY137_23385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_23395	COG4774	siderophore transport
FY137_23395	COG1629	transport
FY137_23400	COG1960	acyl-CoA dehydrogenase activity
FY137_23405	COG0583	DNA-binding transcription factor activity
FY137_23415	COG1609	Transcriptional regulator
FY137_23435	COG3842	ATPase activity
FY137_23445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY137_23450	COG0583	DNA-binding transcription factor activity
FY137_23455	COG2814	Major facilitator Superfamily
FY137_23460	COG1473	amidohydrolase
FY137_23475	COG0747	negative chemotaxis
FY137_23480	COG0601	transmembrane transport
FY137_23485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_23490	COG0444	Belongs to the ABC transporter superfamily
FY137_23500	COG0583	DNA-binding transcription factor activity
FY137_23505	COG0747	negative chemotaxis
FY137_23515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_23520	COG0154	amidase activity
FY137_23525	COG0693	protein deglycase activity
FY137_23535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_23540	COG0601	transmembrane transport
FY137_23545	COG4166	transmembrane transport
FY137_23550	COG1473	amidohydrolase
FY137_23555	COG4172	Belongs to the ABC transporter superfamily
FY137_23560	COG2390	Transcriptional regulator
FY137_23570	COG1175	transmembrane transport
FY137_23575	COG0395	ABC-type sugar transport system, permease component
FY137_23595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY137_23625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY137_23635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY137_23640	COG1414	Transcriptional regulator
FY137_23645	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_23655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY137_23660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY137_23665	COG1121	(ABC) transporter
FY137_23670	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY137_23680	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY137_23685	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY137_23690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY137_23695	COG0471	metal ion transport
FY137_23695	COG3273	potassium ion transport
FY137_23705	COG1253	flavin adenine dinucleotide binding
FY137_23710	COG1309	transcriptional regulator
FY137_23725	COG1609	Transcriptional regulator
FY137_23730	COG1070	Carbohydrate kinase
FY137_23735	COG2115	Belongs to the xylose isomerase family
FY137_23745	COG0778	Nitroreductase
FY137_23750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY137_23755	COG2011	ABC-type metal ion transport system permease component
FY137_23765	COG3300	MHYT domain
FY137_23765	COG5001	Diguanylate cyclase
FY137_23770	COG1054	Belongs to the UPF0176 family
FY137_23780	COG2954	triphosphatase activity
FY137_23785	COG0800	Aldolase
FY137_23805	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY137_23845	COG0523	cobalamin synthesis protein
FY137_23855	COG1846	Transcriptional regulator
FY137_23860	COG1609	Transcriptional regulator
FY137_23865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY137_23875	COG3718	enzyme involved in inositol metabolism
FY137_23885	COG3962	Belongs to the TPP enzyme family
FY137_23890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_23905	COG0411	ABC transporter
FY137_23910	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY137_23920	COG0683	leucine binding
FY137_23935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_23945	COG0747	negative chemotaxis
FY137_23975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY137_23980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY137_23985	COG1126	abc transporter atp-binding protein
FY137_23990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_23995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_24000	COG0765	amino acid transport
FY137_24005	COG0765	amino acid transport
FY137_24015	COG3485	protocatechuate 3,4-dioxygenase
FY137_24020	COG3485	protocatechuate 3,4-dioxygenase
FY137_24025	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY137_24035	COG0583	DNA-binding transcription factor activity
FY137_24050	COG1414	Transcriptional regulator
FY137_24060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY137_24065	COG0183	Belongs to the thiolase family
FY137_24070	COG1609	Transcriptional regulator
FY137_24085	COG1082	Xylose isomerase domain protein TIM barrel
FY137_24090	COG0673	inositol 2-dehydrogenase activity
FY137_24100	COG1609	Transcriptional regulator
FY137_24105	COG0395	ABC-type sugar transport system, permease component
FY137_24110	COG1175	transmembrane transport
FY137_24115	COG3842	ATPase activity
FY137_24125	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY137_24145	COG2814	Major facilitator Superfamily
FY137_24150	COG4774	siderophore transport
FY137_24155	COG3712	iron ion homeostasis
FY137_24165	COG1940	carbohydrate kinase activity
FY137_24175	COG3842	ATPase activity
FY137_24180	COG4149	molybdate abc transporter
FY137_24190	COG0584	glycerophosphoryl diester phosphodiesterase
FY137_24195	COG0483	inositol monophosphate 1-phosphatase activity
FY137_24200	COG0300	oxidoreductase activity
FY137_24215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY137_24260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY137_24280	COG0385	Bile acid
FY137_24285	COG0667	Aldo Keto reductase
FY137_24290	COG0583	DNA-binding transcription factor activity
FY137_24305	COG2942	2-epimerase
FY137_24310	COG1132	(ABC) transporter
FY137_24320	COG0438	transferase activity, transferring glycosyl groups
FY137_24350	COG3436	PFAM IS66 Orf2 family protein
FY137_24375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY137_24380	COG0438	transferase activity, transferring glycosyl groups
FY137_24400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_24405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_24410	COG1120	ATPase activity
FY137_24415	COG4774	siderophore transport
FY137_24420	COG0210	DNA helicase
FY137_24425	COG4608	Belongs to the ABC transporter superfamily
FY137_24430	COG0444	Belongs to the ABC transporter superfamily
FY137_24435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_24440	COG0601	transmembrane transport
FY137_24445	COG2186	Transcriptional regulator
FY137_24465	COG3300	MHYT domain
FY137_24465	COG5001	Diguanylate cyclase
FY137_24470	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_24480	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY137_24490	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY137_24495	COG0306	phosphate transporter
FY137_24500	COG1392	Phosphate transport regulator
FY137_24515	COG1566	PFAM secretion protein HlyD family protein
FY137_24525	COG2205	protein histidine kinase activity
FY137_24540	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY137_24550	COG4774	siderophore transport
FY137_24560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_24565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_24570	COG1120	ATPase activity
FY137_24615	COG1012	belongs to the aldehyde dehydrogenase family
FY137_24620	COG0583	DNA-binding transcription factor activity
FY137_24630	COG3119	arylsulfatase activity
FY137_24635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY137_24640	COG3842	ATPase activity
FY137_24645	COG0165	Argininosuccinate lyase
FY137_24650	COG0395	ABC-type sugar transport system, permease component
FY137_24655	COG1175	transmembrane transport
FY137_24660	COG2182	Extracellular solute-binding protein
FY137_24665	COG1940	carbohydrate kinase activity
FY137_24690	COG1486	melibiose metabolic process
FY137_24695	COG0747	negative chemotaxis
FY137_24700	COG0601	transmembrane transport
FY137_24705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_24710	COG4172	Belongs to the ABC transporter superfamily
FY137_24715	COG1486	melibiose metabolic process
FY137_24720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY137_24725	COG0842	Transport permease protein
FY137_24725	COG1129	ABC transporter
FY137_24730	COG0842	Transport permease protein
FY137_24745	COG0784	Response regulator, receiver
FY137_24750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY137_24760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_24765	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY137_24780	COG0765	amino acid transport
FY137_24790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY137_24800	COG3938	Belongs to the proline racemase family
FY137_24820	COG0765	amino acid transport
FY137_24825	COG0765	amino acid transport
FY137_24835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY137_24850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY137_24870	COG3383	formate dehydrogenase (NAD+) activity
FY137_24880	COG2223	nitrite transmembrane transporter activity
FY137_24885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY137_24900	COG0747	negative chemotaxis
FY137_24905	COG0601	transmembrane transport
FY137_24910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_24915	COG4172	Belongs to the ABC transporter superfamily
FY137_24920	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_24930	COG2186	Transcriptional regulator
FY137_24935	COG0747	negative chemotaxis
FY137_24940	COG0601	transmembrane transport
FY137_24945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_24950	COG0405	Gamma-glutamyltransferase
FY137_24960	COG0483	inositol monophosphate 1-phosphatase activity
FY137_24970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY137_24975	COG0395	ABC-type sugar transport system, permease component
FY137_25005	COG3181	Tripartite tricarboxylate transporter family receptor
FY137_25010	COG5265	(ABC) transporter
FY137_25015	COG0488	(ABC) transporter
FY137_25045	COG0110	maltose O-acetyltransferase activity
FY137_25065	COG1129	ABC transporter
FY137_25070	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_25075	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_25090	COG1082	Xylose isomerase domain protein TIM barrel
FY137_25115	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FY137_25120	COG2814	Major facilitator Superfamily
FY137_25125	COG4178	(ABC) transporter
FY137_25140	COG1940	carbohydrate kinase activity
FY137_25140	COG1846	Transcriptional regulator
FY137_25160	COG1069	ribulokinase activity
FY137_25165	COG1349	DNA-binding transcription factor activity
FY137_25170	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_25205	COG0395	ABC-type sugar transport system, permease component
FY137_25215	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_25230	COG0640	Transcriptional regulator
FY137_25260	COG1192	Involved in chromosome partitioning
FY137_25265	COG1475	DNA binding
FY137_25270	COG0640	Transcriptional regulator
FY137_25285	COG1126	abc transporter atp-binding protein
FY137_25290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY137_25295	COG1609	Transcriptional regulator
FY137_25325	COG3239	Fatty acid desaturase
FY137_25335	COG1278	Cold shock
FY137_25415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY137_25415	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY137_25450	COG4191	Histidine kinase
FY137_25455	COG1132	(ABC) transporter
FY137_25465	COG0640	Transcriptional regulator
FY137_25495	COG4977	sequence-specific DNA binding
FY137_25500	COG2211	Major facilitator Superfamily
FY137_25505	COG2807	transmembrane transport
FY137_25510	COG1846	Transcriptional regulator
FY137_25525	COG2814	Major facilitator Superfamily
FY137_25555	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY137_25570	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY137_25575	COG0583	DNA-binding transcription factor activity
FY137_25590	COG0071	Belongs to the small heat shock protein (HSP20) family
FY137_25635	COG3838	Conjugal transfer protein Trbc
FY137_25640	COG3702	type iv secretory pathway
FY137_25645	COG3451	type IV secretory pathway VirB4
FY137_25660	COG3704	protein secretion by the type IV secretion system
FY137_25670	COG3736	Type IV secretory pathway, component VirB8
FY137_25675	COG3504	Conjugal transfer protein
FY137_25680	COG2948	multi-organism process
FY137_25685	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY137_25785	COG3831	ATPase activity
FY137_25800	COG3505	Type IV secretory pathway VirD4
FY137_25825	COG0583	DNA-binding transcription factor activity
FY137_25865	COG0745	RESPONSE REGULATOR receiver
FY137_25905	COG3842	ATPase activity
FY137_25910	COG4208	sulfate ABC transporter
FY137_25915	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY137_25935	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY137_25940	COG1942	4-Oxalocrotonate Tautomerase
FY137_25950	COG3971	2-oxopent-4-enoate hydratase activity
FY137_25960	COG1414	Transcriptional regulator
FY137_25970	COG1137	ATPase activity
FY137_25985	COG4177	L-phenylalanine transmembrane transporter activity
FY137_26005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY137_26010	COG1175	transmembrane transport
FY137_26015	COG0395	ABC-type sugar transport system, permease component
FY137_26025	COG0366	Alpha amylase catalytic
FY137_26030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY137_26035	COG1082	Xylose isomerase domain protein TIM barrel
FY137_26040	COG3842	ATPase activity
FY137_26050	COG1940	carbohydrate kinase activity
FY137_26055	COG0395	ABC-type sugar transport system, permease component
FY137_26065	COG2182	Extracellular solute-binding protein
FY137_26070	COG0673	inositol 2-dehydrogenase activity
FY137_26100	COG1126	abc transporter atp-binding protein
FY137_26105	COG0765	amino acid transport
FY137_26110	COG0765	amino acid transport
FY137_26120	COG4608	Belongs to the ABC transporter superfamily
FY137_26130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_26145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_26150	COG0583	DNA-binding transcription factor activity
FY137_26155	COG2423	ornithine cyclodeaminase activity
FY137_26165	COG1957	nucleoside hydrolase
FY137_26180	COG1335	isochorismatase
FY137_26185	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_26230	COG0583	DNA-binding transcription factor activity
FY137_26235	COG1902	pentaerythritol trinitrate reductase activity
FY137_26240	COG0583	DNA-binding transcription factor activity
FY137_26245	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_26255	COG1335	isochorismatase
FY137_26260	COG0583	DNA-binding transcription factor activity
FY137_26270	COG1695	Transcriptional regulator
FY137_26350	COG2207	Transcriptional regulator
FY137_26395	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_26410	COG1802	Transcriptional regulator
FY137_26415	COG3485	protocatechuate 3,4-dioxygenase
FY137_26420	COG3971	2-oxopent-4-enoate hydratase activity
FY137_26435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY137_26440	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY137_26455	COG1063	alcohol dehydrogenase
FY137_26465	COG1960	acyl-CoA dehydrogenase activity
FY137_26470	COG1024	Enoyl-CoA hydratase
FY137_26480	COG1012	belongs to the aldehyde dehydrogenase family
FY137_26485	COG0477	Major facilitator Superfamily
FY137_26500	COG3706	GGDEF domain
FY137_26520	COG1846	Transcriptional regulator
FY137_26560	COG1012	belongs to the aldehyde dehydrogenase family
FY137_26570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY137_26580	COG3386	PFAM SMP-30 Gluconolaconase
FY137_26585	COG3622	Belongs to the hyi family
FY137_26590	COG2084	Dehydrogenase
FY137_26615	COG1940	carbohydrate kinase activity
FY137_26620	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY137_26630	COG1129	ABC transporter
FY137_26650	COG0583	DNA-binding transcription factor activity
FY137_26655	COG2271	Major facilitator Superfamily
FY137_26665	COG2272	Belongs to the type-B carboxylesterase lipase family
FY137_26685	COG1129	ABC transporter
FY137_26710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY137_26720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY137_26755	COG0583	DNA-binding transcription factor activity
FY137_26760	COG1414	Transcriptional regulator
FY137_26770	COG4948	Mandelate Racemase Muconate Lactonizing
FY137_26780	COG3842	ATPase activity
FY137_26785	COG1175	transmembrane transport
FY137_26790	COG0395	ABC-type sugar transport system, permease component
FY137_26800	COG0477	Major facilitator Superfamily
FY137_26835	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY137_26855	COG0747	negative chemotaxis
FY137_26865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_26880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY137_26890	COG4215	(ABC) transporter
FY137_26945	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY137_26950	COG0251	oxidation-reduction process
FY137_26955	COG3547	Transposase (IS116 IS110 IS902 family)
FY137_26990	COG1028	Short-chain dehydrogenase reductase Sdr
FY137_26995	COG1335	isochorismatase
FY137_27005	COG1309	transcriptional regulator
FY137_27010	COG4604	ABC transporter, ATP-binding protein
FY137_27015	COG4605	iron ion homeostasis
FY137_27020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY137_27030	COG2132	Multicopper oxidase
FY137_27035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY137_27040	COG4771	TonB-dependent receptor
FY137_27075	COG1695	Transcriptional regulator
FY137_27110	COG2132	Multicopper oxidase
FY137_27145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY137_27165	COG1192	Involved in chromosome partitioning
FY137_27170	COG1475	DNA binding
FY137_27175	COG0640	Transcriptional regulator
FY137_27180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY137_27210	COG2211	Major facilitator Superfamily
FY137_27255	COG4974	Belongs to the 'phage' integrase family
FY137_27260	COG1051	belongs to the nudix hydrolase family
FY137_27300	COG1475	DNA binding
FY137_27325	COG2824	Alkylphosphonate utilization operon protein PhnA
FY137_27345	COG1280	lysine exporter protein (LysE YggA)
FY137_27360	COG5489	Protein of unknown function (DUF736)
FY137_27445	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY137_27460	COG0747	negative chemotaxis
FY137_27480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_27485	COG0584	glycerophosphoryl diester phosphodiesterase
FY137_27490	COG0483	inositol monophosphate 1-phosphatase activity
FY137_27555	COG3161	chorismate lyase activity
FY137_27705	COG3436	PFAM IS66 Orf2 family protein
FY137_27800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY137_27830	COG0583	DNA-binding transcription factor activity
FY137_27835	COG0747	negative chemotaxis
FY137_27850	COG0252	asparaginase activity
FY137_27855	COG0583	DNA-binding transcription factor activity
FY137_27875	COG3842	ATPase activity
FY137_27900	COG3701	Conjugal transfer protein
FY137_27905	COG3846	protein secretion by the type IV secretion system
FY137_27915	COG5314	conjugation
FY137_27920	COG3451	type IV secretory pathway VirB4
FY137_27935	COG4962	Type ii secretion system protein e