locus-tag class description AWN88_00020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_00025 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_00030 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AWN88_00045 ENOG4105ECQ AraC Family Transcriptional Regulator AWN88_00050 ENOG4105ECQ AraC Family Transcriptional Regulator AWN88_00055 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme AWN88_00060 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AWN88_00075 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_00100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_00105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_00110 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_00120 ENOG4105ETT transcriptional Regulator, LysR family AWN88_00260 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AWN88_00265 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AWN88_00270 ENOG4105KME endoribonuclease L-psp AWN88_00290 ENOG4105CHU acetyl-coa acetyltransferase AWN88_00305 ENOG4105C0Z ABC transporter AWN88_00310 ENOG4108IV0 ABC, transporter AWN88_00315 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AWN88_00325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AWN88_00350 ENOG4105EG2 ABC transporter, permease AWN88_00355 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AWN88_00360 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_00385 ENOG4105FVZ flavin reductase domain protein, FMN-binding AWN88_00395 ENOG4105C26 Dehydrogenase AWN88_00405 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AWN88_00410 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWN88_00415 ENOG4105ETE Transcriptional regulator (LacI family AWN88_00420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_00430 ENOG4108JQ7 (ABC) transporter AWN88_00445 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_00450 ENOG4105C5I Dehydrogenase AWN88_00465 ENOG4107Z3H Transcriptional regulator, TetR family AWN88_00480 ENOG4105ETE Transcriptional regulator (LacI family AWN88_00485 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_00490 ENOG41079KZ Major Facilitator Superfamily AWN88_00510 ENOG4105CC9 acyl-Coa dehydrogenase AWN88_00515 ENOG4105C1G acyl-Coa dehydrogenase AWN88_00520 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWN88_00530 ENOG4105C0Z ABC transporter AWN88_00535 ENOG4108IV0 ABC, transporter AWN88_00570 ENOG4105FKQ transcriptional regulator AWN88_00640 ENOG4105FA0 parb-like partition protein AWN88_00670 ENOG4105KK6 nuclease AWN88_00735 ENOG4105CM2 brancheD-chain amino acid aminotransferase AWN88_00740 ENOG4108JEH abc transporter atp-binding protein AWN88_00745 ENOG4105DMR ABC, transporter AWN88_00750 ENOG4105E5Q amino acid AbC transporter AWN88_00760 ENOG4105II7 pyrroline-5-carboxylate reductase AWN88_00765 ENOG4105DRR Transcriptional regulator, GntR family AWN88_00770 ENOG4105EW9 transcriptional regulator AsnC family AWN88_00880 ENOG4105EQ2 LysR family Transcriptional regulator AWN88_00885 ENOG4105ENX hydrolase AWN88_00890 ENOG4105ENX hydrolase AWN88_00925 ENOG41090JH (ATPase)-like protein AWN88_00955 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) AWN88_00965 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA AWN88_01070 ENOG4105FA0 parb-like partition protein AWN88_01105 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWN88_01110 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWN88_01155 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AWN88_01165 ENOG4105CMM transposase AWN88_01170 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AWN88_01180 ENOG4105C10 Electron transfer flavoprotein AWN88_01185 ENOG4105BZJ Electron transfer flavoprotein AWN88_01195 ENOG4105CSH Transporter AWN88_01205 ENOG4105QPS Monooxygenase AWN88_01230 ENOG41061A5 transposase AWN88_01240 ENOG4105E5H Transposase AWN88_01255 ENOG4105C8Q Methyl-accepting chemotaxis AWN88_01265 ENOG4105J1P transposase, IS3 IS911 family protein AWN88_01275 ENOG4105EKQ RNA-directed DNA polymerase AWN88_01295 ENOG4105C4Y ABC transporter AWN88_01300 ENOG4105D38 putrescine abc transporter AWN88_01305 ENOG4105F38 ABC transporter, permease AWN88_01310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_01315 ENOG4108UAU isochorismatase AWN88_01330 ENOG4105RE0 Asp Glu hydantoin racemase AWN88_01340 ENOG4105C26 Dehydrogenase AWN88_01375 ENOG4105MGM doxx family AWN88_01390 ENOG4105CC0 LysR family Transcriptional regulator AWN88_01395 ENOG4107XAN XdhC and CoxI family AWN88_01445 ENOG4105KVH Transcriptional regulator AWN88_01625 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AWN88_01630 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_01635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_01645 ENOG4108JQ7 (ABC) transporter AWN88_01650 ENOG4107FB0 transcriptional regulator DeoR family AWN88_01655 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AWN88_01675 ENOG4105CPD ethanolamine ammonia-lyase AWN88_01685 ENOG4105EEQ Na H antiporter AWN88_01695 ENOG4105CQ0 ABC transporter AWN88_01725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AWN88_01730 ENOG4105E0F Histidine kinase AWN88_01735 ENOG4108ZHJ Organic hydroperoxide resistance protein AWN88_01745 ENOG4105CIR epoxide hydrolase AWN88_01770 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AWN88_01780 ENOG4108ZXC Two component transcriptional regulator, luxr family AWN88_01795 ENOG4105F0F Oxalate decarboxylase AWN88_01805 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AWN88_01825 ENOG4108JJ7 ABC transporter AWN88_01890 ENOG4108Z9Z response to DNA damage stimulus AWN88_01930 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AWN88_01940 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase AWN88_01960 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AWN88_01985 ENOG4105BZ9 Cytochrome C oxidase, subunit I AWN88_01990 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AWN88_02000 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AWN88_02055 ENOG4105VDW Csbd family AWN88_02075 ENOG4108IJ6 ABC transporter AWN88_02085 ENOG4105ECY inositol monophosphatase AWN88_02090 ENOG4108JQ6 ABC transporter AWN88_02095 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AWN88_02100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_02110 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_02115 ENOG4108QBF Transcriptional regulator AWN88_02125 ENOG4105CXK mandelate racemase muconate lactonizing AWN88_02130 ENOG4108JQ6 ABC transporter AWN88_02135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_02140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_02160 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AWN88_02165 ENOG4105FCD Major Facilitator AWN88_02175 ENOG4108JB9 formate dehydrogenase AWN88_02180 ENOG4107QIZ NADH dehydrogenase AWN88_02195 ENOG410633P Hydantoin racemase AWN88_02200 ENOG4107XWI flavin reductase domain protein, FMN-binding AWN88_02205 ENOG4105DRR Transcriptional regulator, GntR family AWN88_02210 ENOG4108JQ7 (ABC) transporter AWN88_02215 ENOG4105C3U ABC transporter AWN88_02220 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AWN88_02230 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_02235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_02245 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AWN88_02255 ENOG4105BZU Histidine kinase AWN88_02260 ENOG4105C5I Dehydrogenase AWN88_02270 ENOG4105EAD ABC transporter AWN88_02275 ENOG4105E5Q amino acid AbC transporter AWN88_02280 ENOG4105CT1 (ABC) transporter AWN88_02290 ENOG4105ETE Transcriptional regulator (LacI family AWN88_02295 ENOG4105CTU Proline racemase AWN88_02305 ENOG4105MWK D-amino acid dehydrogenase, small subunit AWN88_02315 ENOG4105E5Q amino acid AbC transporter AWN88_02320 ENOG4105E5Q amino acid AbC transporter AWN88_02330 ENOG4105DG4 malate L-lactate dehydrogenase AWN88_02335 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_02345 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AWN88_02350 ENOG41074H6 response regulator AWN88_02360 ENOG4105CMI transporter AWN88_02365 ENOG4105CJ1 ABC, transporter AWN88_02370 ENOG4105D0S secretion protein (HlyD AWN88_02375 ENOG4105F8D glycoside hydrolase family 4 AWN88_02380 ENOG4108JQ5 ABC transporter AWN88_02385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_02425 ENOG4105DKQ ROK family AWN88_02430 ENOG4107FKK extracellular solute-binding protein family 1 AWN88_02440 ENOG4105DRS transport system, permease AWN88_02445 ENOG4106IQC argininosuccinate lyase AWN88_02455 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AWN88_02460 ENOG4105CBG Sulfatase AWN88_02480 ENOG4108IV0 ABC, transporter AWN88_02485 ENOG4105C0Z ABC transporter AWN88_02495 ENOG4105C32 Amino acid ABC transporter (Permease) AWN88_02505 ENOG4107XVH Transcriptional regulator AWN88_02515 ENOG4105E0A ABC, transporter AWN88_02520 ENOG4108IHU transport system permease protein AWN88_02525 ENOG4105DQ5 transport system permease protein AWN88_02535 ENOG4105E0K tonB-dependent siderophore receptor AWN88_02545 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AWN88_02575 ENOG4107GRR phosphate transport regulator AWN88_02580 ENOG4107QXV Phosphate transporter AWN88_02585 ENOG4105FDF Could be involved in DNA repair (By similarity) AWN88_02590 ENOG4105DQE DNA ligase AWN88_02595 ENOG4105FDF Could be involved in DNA repair (By similarity) AWN88_02605 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AWN88_02610 ENOG4105BZU Histidine kinase AWN88_02620 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_02630 ENOG4107YCY Transcriptional regulator AWN88_02635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_02650 ENOG4108JQ7 (ABC) transporter AWN88_02660 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AWN88_02675 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWN88_02680 ENOG4105ETE Transcriptional regulator (LacI family AWN88_02690 ENOG4105C4R Atp-dependent dna helicase AWN88_02725 ENOG4106IQQ AWN88_02745 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AWN88_02760 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AWN88_02775 ENOG4105CEY Amp-dependent synthetase and ligase AWN88_02790 ENOG4108IUS Transketolase AWN88_02795 ENOG4108HHA Transketolase AWN88_02825 ENOG4105HEI LysR family (Transcriptional regulator AWN88_02830 ENOG4105CPC Aldo Keto reductase AWN88_02835 ENOG4105C09 Bile acid AWN88_02860 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AWN88_02865 ENOG4108Z4U Ferredoxin AWN88_02880 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AWN88_02890 ENOG4105E0C molybdate abc transporter AWN88_02895 ENOG4108IJ9 (ABC) transporter AWN88_02905 ENOG4105E2R ROK family AWN88_02920 ENOG4105F5H Glycosyl Hydrolase Family 88 AWN88_02930 ENOG4108IJ9 (ABC) transporter AWN88_02940 ENOG4105DRS transport system, permease AWN88_02950 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_02975 ENOG4107STF Involved in phosphonate degradation (By similarity) AWN88_02985 ENOG4108KB1 transcriptional regulator, arac family AWN88_02990 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AWN88_03000 ENOG4105C01 Dihydroxy-acid dehydratase AWN88_03005 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AWN88_03010 ENOG4105C2J ABC transporter AWN88_03015 ENOG4107R9N ABC transporter AWN88_03020 ENOG41062B0 ABC transporter, permease AWN88_03025 ENOG4107EJG GntR family transcriptional regulator AWN88_03070 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_03080 ENOG4105XN3 extracellular solute-binding protein family 1 AWN88_03090 ENOG4105EPC oxidoreductase AWN88_03110 ENOG4107RP9 extracellular solute-binding protein, family 3 AWN88_03120 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) AWN88_03125 ENOG4107QMS site-determining protein AWN88_03130 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AWN88_03140 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AWN88_03145 ENOG4107YCY Transcriptional regulator AWN88_03150 ENOG4108ERU trap dicarboxylate transporter subunit DctP AWN88_03160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_03165 ENOG4105CPQ Dehydrogenase AWN88_03170 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AWN88_03185 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AWN88_03190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_03195 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AWN88_03205 ENOG41080HT Transcriptional regulator, arsr family AWN88_03210 ENOG4105CYM Glutathione S-transferase AWN88_03220 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) AWN88_03235 ENOG41069H0 dihydroorotase EC 3.5.2.3 AWN88_03250 ENOG4106R87 Extracellular solute-binding protein, family 5 AWN88_03255 ENOG4105JNK Glycosyl transferase (Group 1 AWN88_03290 ENOG4107QM2 Aldo Keto reductase AWN88_03300 ENOG4105FDP GntR family transcriptional regulator AWN88_03305 ENOG4108IJ9 (ABC) transporter AWN88_03310 ENOG4107T3P ABC, transporter AWN88_03315 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AWN88_03320 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_03325 ENOG4105CJQ hydrolase, family 31 AWN88_03330 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component AWN88_03335 ENOG4107Z6I Thiamine biosynthesis protein AWN88_03340 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AWN88_03345 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AWN88_03360 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AWN88_03365 ENOG4105MWK D-amino acid dehydrogenase, small subunit AWN88_03390 ENOG4105CK2 sodium dicarboxylate symporter AWN88_03400 ENOG4105C8Y Acetylornithine aminotransferase AWN88_03405 ENOG4106PGW Short-chain dehydrogenase reductase Sdr AWN88_03415 ENOG4105CH2 amidohydrolase AWN88_03435 ENOG4107QZ7 Cellulose synthase catalytic subunit AWN88_03445 ENOG4107SZR mannose-6-phosphate isomerase AWN88_03465 ENOG4105CMR udp-glucose 4-epimerase AWN88_03480 ENOG4105WH1 Two component transcriptional regulator luxr family AWN88_03495 ENOG4108JJ6 Type I secretion system ATPase AWN88_03500 ENOG4107QZV Type I secretion membrane fusion protein AWN88_03530 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AWN88_03535 ENOG4105C3R Methionine synthase AWN88_03550 ENOG4106TNF Periplasmic binding protein AWN88_03555 ENOG4108JEH abc transporter atp-binding protein AWN88_03575 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AWN88_03585 ENOG4105CHR reductase AWN88_03595 ENOG4108VX5 3-methyladenine DNA glycosylase AWN88_03605 ENOG4105FKQ transcriptional regulator AWN88_03610 ENOG4107T3P ABC, transporter AWN88_03625 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_03635 ENOG4107RJ5 oxidoreductase AWN88_03640 ENOG4107SPB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AWN88_03645 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AWN88_03650 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AWN88_03655 ENOG4105D9R oxidoreductase AWN88_03670 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AWN88_03675 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AWN88_03705 ENOG4106NZI LysR family Transcriptional regulator AWN88_03710 ENOG4105C6K Malic enzyme AWN88_03725 ENOG4105DRP amino acid AbC transporter AWN88_03735 ENOG4108PGP mmge prpd family protein AWN88_03740 ENOG4105CPU Monooxygenase AWN88_03745 ENOG4107SDU Methyl-accepting chemotaxis AWN88_03750 ENOG4105MWK D-amino acid dehydrogenase, small subunit AWN88_03770 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_03775 ENOG4105CH5 extracellular solute-binding protein, family 7 AWN88_03780 ENOG4108Z86 Glutamine amidotransferase AWN88_03785 ENOG4105CNN ABC, transporter AWN88_03790 ENOG4105C2J ABC transporter AWN88_03800 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AWN88_03815 ENOG4108JQ6 ABC transporter AWN88_03820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_03830 ENOG4105EGI Transcriptional regulator AWN88_03835 ENOG4105D44 asparaginase AWN88_03850 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_03870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_03875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_03880 ENOG4108S01 response regulator AWN88_03885 ENOG4105JSC dimethylmenaquinone methyltransferase AWN88_03890 ENOG4105E9Z Nad-dependent epimerase dehydratase AWN88_03905 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AWN88_03910 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AWN88_03920 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AWN88_03925 ENOG4105D9R oxidoreductase AWN88_03960 ENOG4105E0A ABC, transporter AWN88_03965 ENOG4105EHG Permease protein AWN88_03980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWN88_03990 ENOG4105E0A ABC, transporter AWN88_03995 ENOG4105EHG Permease protein AWN88_04010 ENOG4105CWC Acetylornithine deacetylase AWN88_04015 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AWN88_04025 ENOG4105C26 Dehydrogenase AWN88_04030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AWN88_04035 ENOG4105C26 Dehydrogenase AWN88_04045 ENOG4105ECY inositol monophosphatase AWN88_04065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_04070 ENOG4107RCV ABC transporter, permease AWN88_04075 ENOG4105ETE Transcriptional regulator (LacI family AWN88_04080 ENOG4105EAM Na Pi-cotransporter AWN88_04115 ENOG4105CMG Carbohydrate kinase AWN88_04125 ENOG4105CNN ABC, transporter AWN88_04135 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AWN88_04145 ENOG4105CPQ Dehydrogenase AWN88_04150 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_04155 ENOG4107RCV ABC transporter, permease AWN88_04160 ENOG4105C4Y ABC transporter AWN88_04165 ENOG4105C4Y ABC transporter AWN88_04180 ENOG4108IG5 Transcriptional regulator AWN88_04190 ENOG4105CHR reductase AWN88_04195 ENOG4108FUF Transcriptional regulator, IclR family AWN88_04200 ENOG4105CMR udp-glucose 4-epimerase AWN88_04205 ENOG4108IJ9 (ABC) transporter AWN88_04210 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_04215 ENOG4105D56 permease protein AWN88_04225 ENOG4105CXK mandelate racemase muconate lactonizing AWN88_04230 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_04235 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 AWN88_04255 ENOG41066DG (EAL) domain protein AWN88_04275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AWN88_04290 ENOG4108IJ8 ABC transporter AWN88_04295 ENOG4105E90 ABC transporter AWN88_04310 ENOG4105CZE histidine utilization repressor AWN88_04315 ENOG4105C84 Histidine ammonia-lyase AWN88_04375 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AWN88_04390 ENOG4105EMU Dehydrogenase AWN88_04395 ENOG4105ECQ AraC Family Transcriptional Regulator AWN88_04450 ENOG4105CPQ Dehydrogenase AWN88_04455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_04490 ENOG4105DQE DNA ligase AWN88_04505 ENOG4108ZNX Heat shock protein AWN88_04510 ENOG4105DQE DNA ligase AWN88_04540 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AWN88_04565 ENOG4108ETV ABC transporter AWN88_04585 ENOG4106RZ4 Peptidase U32 AWN88_04590 ENOG4105CFP Peptidase U32 AWN88_04600 ENOG4105K78 MarR family Transcriptional regulator AWN88_04605 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AWN88_04610 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AWN88_04620 ENOG4105CCU oxidase (Subunit III) AWN88_04640 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AWN88_04680 ENOG4108NH8 Cation transport protein AWN88_04710 ENOG4108K3A Glutathione S-transferase AWN88_04715 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AWN88_04730 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AWN88_04735 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AWN88_04740 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AWN88_04745 ENOG4105BZU Histidine kinase AWN88_04750 ENOG4105D64 Mechanosensitive ion channel AWN88_04775 ENOG4108ZXC Two component transcriptional regulator, luxr family AWN88_04790 ENOG4105D8X mechanosensitive ion channel AWN88_04800 ENOG4108IG5 Transcriptional regulator AWN88_04830 ENOG4108A65 Transcriptional regulator AWN88_04840 ENOG4105CAU Arsenical resistance protein, ArsH AWN88_04850 ENOG4105D6J arsenicaL-resistance protein AWN88_04900 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWN88_04905 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWN88_04980 ENOG4105E4C Lytic transglycosylase catalytic AWN88_04985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AWN88_04995 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AWN88_05000 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AWN88_05005 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AWN88_05010 ENOG4105CFH Aspartokinase AWN88_05025 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) AWN88_05060 ENOG41074H6 response regulator AWN88_05075 ENOG4105EW9 transcriptional regulator AsnC family AWN88_05085 ENOG4105E2Y ABC, transporter AWN88_05090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AWN88_05095 ENOG4105GVF (ABC) transporter AWN88_05100 ENOG4105C26 Dehydrogenase AWN88_05105 ENOG4105ETT transcriptional Regulator, LysR family AWN88_05115 ENOG4105C6Y Udp-glucose 6-dehydrogenase AWN88_05120 ENOG4105C1B dTDP-glucose 4-6-dehydratase AWN88_05125 ENOG4105D7Z glutathione synthase AWN88_05150 ENOG4108Z0Z intracellular protease Pfpi family AWN88_05170 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AWN88_05175 ENOG4108302 MgtC SapB transporter AWN88_05180 ENOG4108Z9Z response to DNA damage stimulus AWN88_05185 ENOG4105DZG Dehydrogenase AWN88_05200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AWN88_05215 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AWN88_05220 ENOG4105C32 Amino acid ABC transporter (Permease) AWN88_05225 ENOG4108IV0 ABC, transporter AWN88_05230 ENOG4105C0Z ABC transporter AWN88_05250 ENOG4105DIA mandelate racemase muconate lactonizing AWN88_05260 ENOG4105DEI Mannitol dehydrogenase AWN88_05265 ENOG4108JQ7 (ABC) transporter AWN88_05270 ENOG4105C3U ABC transporter AWN88_05275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_05280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_05285 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_05295 ENOG4105EMU Dehydrogenase AWN88_05325 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AWN88_05330 ENOG4105CAT Cytidine monophosphate kinase AWN88_05360 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AWN88_05365 ENOG4108IYU L-aspartate oxidase AWN88_05370 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AWN88_05395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AWN88_05400 ENOG4105C4M (Ubiquinol oxidase) subunit I AWN88_05405 ENOG4108JJ8 (ABC) transporter AWN88_05410 ENOG4108JJ9 ABC, transporter AWN88_05420 ENOG4105CPQ Dehydrogenase AWN88_05425 ENOG4105CHR reductase AWN88_05430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWN88_05440 ENOG4108UYU AsnC family transcriptional regulator AWN88_05455 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AWN88_05460 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AWN88_05465 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AWN88_05470 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AWN88_05475 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AWN88_05500 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWN88_05515 ENOG4105DDR sarcosine oxidase (Beta subunit) AWN88_05520 ENOG4105K5G 30S ribosomal protein S21 AWN88_05605 ENOG4105CQZ Histidine kinase AWN88_05615 ENOG4108HQS Glycine betaine AWN88_05620 ENOG4108IJ7 Glycine betaine AWN88_05625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AWN88_05635 ENOG4105D3G Pseudouridine synthase AWN88_05640 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AWN88_05660 ENOG4105WH1 Two component transcriptional regulator luxr family AWN88_05665 ENOG4105BZU Histidine kinase AWN88_05670 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AWN88_05675 ENOG4105C2J ABC transporter AWN88_05710 ENOG4105E0A ABC, transporter AWN88_05715 ENOG4105S6R Iron-hydroxamate transporter permease subunit AWN88_05725 ENOG4105E0K tonB-dependent siderophore receptor AWN88_05730 ENOG4106NZI LysR family Transcriptional regulator AWN88_05740 ENOG4105DIJ Phosphoethanolamine transferase AWN88_05745 ENOG4105XJC Two component transcriptional regulator (Winged helix family AWN88_05750 ENOG4105ECM Sensor protein basS pmrB AWN88_05755 ENOG4105CSH Transporter AWN88_05770 ENOG4105F8J Adenylate Guanylate cyclase AWN88_05780 ENOG4105DFI Membrane AWN88_05820 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AWN88_05825 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AWN88_05830 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AWN88_05840 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AWN88_05845 ENOG4105K5X acetyltransferase AWN88_05880 ENOG4108QIF Phosphoesterase, PA-phosphatase related AWN88_05885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWN88_05890 ENOG41062D9 Histidine kinase AWN88_05895 ENOG4105C57 major facilitator superfamily AWN88_05900 ENOG4105EQ2 LysR family Transcriptional regulator AWN88_05920 ENOG4105EFZ amidohydrolase AWN88_05935 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AWN88_05940 ENOG4105W8I Transcriptional regulator AWN88_05960 ENOG4105C26 Dehydrogenase AWN88_05970 ENOG4107SQD Transcriptional regulator, GntR family AWN88_05985 ENOG4105ENR peptidase, M24 AWN88_05990 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase AWN88_06015 ENOG4105CQ4 Transcriptional regulator AWN88_06020 ENOG4105F0H myo-inositol catabolism protein AWN88_06025 ENOG4105CIB oxidoreductase Domain protein AWN88_06030 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AWN88_06040 ENOG4105DV0 amidase (EC 3.5.1.4 AWN88_06050 ENOG4105CH2 amidohydrolase AWN88_06115 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain AWN88_06120 ENOG4105D7N magnesium and cobalt transport protein CorA AWN88_06125 ENOG4105CKW Inner membrane protein yedI AWN88_06135 ENOG4107QZ7 Cellulose synthase catalytic subunit AWN88_06145 ENOG4105BZU Histidine kinase AWN88_06155 ENOG4108J59 Extracellular solute-binding protein, family 5 AWN88_06160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_06165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_06170 ENOG4108JQ5 ABC transporter AWN88_06185 ENOG4108HFV AWN88_06200 ENOG4105DZR Type I site-specific deoxyribonuclease AWN88_06205 ENOG4108VKG metal-dependent hydrolase AWN88_06225 ENOG4108C33 Resolvase AWN88_06270 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_06275 ENOG4108JQ6 ABC transporter AWN88_06280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_06290 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_06305 ENOG4105C0A alcohol dehydrogenase AWN88_06310 ENOG41073TP transcriptional regulator AWN88_06325 ENOG4105NAU thioesterase Superfamily protein AWN88_06345 ENOG4105NPQ Pfam:DUF403 AWN88_06360 ENOG4105C5H ABC transporter AWN88_06365 ENOG4105C5I Dehydrogenase AWN88_06380 ENOG4108U05 Transcriptional regulator AWN88_06385 ENOG4105CMG Carbohydrate kinase AWN88_06390 ENOG41061GT Aldolase AWN88_06400 ENOG4108FN7 Aldo keto reductase AWN88_06410 ENOG4105CNN ABC, transporter AWN88_06415 ENOG4105C2J ABC transporter AWN88_06450 ENOG4108ZNX Heat shock protein AWN88_06455 ENOG4105DHU Bile acid AWN88_06465 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AWN88_06480 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AWN88_06490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_06495 ENOG4108IJ9 (ABC) transporter AWN88_06500 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AWN88_06505 ENOG4105E98 transcriptional regulator DeoR family AWN88_06510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AWN88_06525 ENOG4108IFG nitrite reductase, (NAD(P)H) AWN88_06530 ENOG4105D7T ABC transporter AWN88_06545 ENOG4105I5W Transporter AWN88_06555 ENOG4105DRR Transcriptional regulator, GntR family AWN88_06560 ENOG4105C5A transporter AWN88_06565 ENOG4105E7W lamb ycsf family protein AWN88_06570 ENOG4105CFM UPF0317 protein AWN88_06575 ENOG4105P4J Allophanate hydrolase, subunit 1 AWN88_06580 ENOG4108JIK carboxylase AWN88_06585 ENOG4105E5K Alpha-amylase AWN88_06590 ENOG4108Z4X TRANSCRIPTIONal AWN88_06595 ENOG4105D05 Receptor AWN88_06600 ENOG4107QYG anthranilate phosphoribosyltransferase AWN88_06640 ENOG4105KME endoribonuclease L-psp AWN88_06655 ENOG41090B9 response to stress AWN88_06665 ENOG4105CGP Urocanate hydratase AWN88_06675 ENOG4105C84 Histidine ammonia-lyase AWN88_06680 ENOG4105CI2 imidazolone-5-propionate hydrolase AWN88_06685 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AWN88_06730 ENOG4107SCK Monooxygenase AWN88_06750 ENOG4105BZU Histidine kinase AWN88_06760 ENOG4105E7U AraC family transcriptional regulator AWN88_06765 ENOG4105E1F short-chain dehydrogenase reductase AWN88_06770 ENOG4105CHR reductase AWN88_06775 ENOG4105KVH Transcriptional regulator AWN88_06810 ENOG4105C2J ABC transporter AWN88_06815 ENOG4105CNN ABC, transporter AWN88_06820 ENOG4105F5R ABC transporter AWN88_06825 ENOG4107TTA Xylose isomerase domain protein TIM barrel AWN88_06830 ENOG4105DBI uridine monophosphokinase AWN88_06835 ENOG4107TTA Xylose isomerase domain protein TIM barrel AWN88_06840 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AWN88_06845 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AWN88_06850 ENOG4105C7W Xanthine dehydrogenase AWN88_06855 ENOG4105EQX glucarate dehydratase AWN88_06865 ENOG4105C5I Dehydrogenase AWN88_06875 ENOG4105CHR reductase AWN88_06885 ENOG4105E0S extracellular solute-binding protein family 1 AWN88_06890 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AWN88_06900 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_06905 ENOG4107XBN GntR Family Transcriptional Regulator AWN88_06910 ENOG4105F04 LysR family Transcriptional regulator AWN88_06915 ENOG4108JQ1 Dehydrogenase AWN88_06920 ENOG4105JSC dimethylmenaquinone methyltransferase AWN88_06940 ENOG4105C5I Dehydrogenase AWN88_06945 ENOG410642W LysR family Transcriptional regulator AWN88_06955 ENOG4105CHR reductase AWN88_06960 ENOG4105K56 Transcriptional regulator AWN88_06980 ENOG4105BZU Histidine kinase AWN88_06995 ENOG4105HEI LysR family (Transcriptional regulator AWN88_07010 ENOG4108WQI RNA Polymerase AWN88_07030 ENOG4105WH1 Two component transcriptional regulator luxr family AWN88_07050 ENOG4105BZU Histidine kinase AWN88_07055 ENOG41074H6 response regulator AWN88_07070 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_07075 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_07080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_07085 ENOG4105C3U ABC transporter AWN88_07090 ENOG4108JQ7 (ABC) transporter AWN88_07115 ENOG4107QRI Phosphoketolase AWN88_07120 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AWN88_07135 ENOG4105KK7 inner membrane protein YiaW AWN88_07140 ENOG4105EFX secretion protein, HlyD family AWN88_07160 ENOG4105HEI LysR family (Transcriptional regulator AWN88_07185 ENOG4105EJC lysr family transcriptional regulator AWN88_07195 ENOG4105R1U AraC Family Transcriptional Regulator AWN88_07215 ENOG4105Y49 secretion protein, HlyD family AWN88_07225 ENOG4105S6R Iron-hydroxamate transporter permease subunit AWN88_07230 ENOG4105E0A ABC, transporter AWN88_07240 ENOG4105E0K tonB-dependent siderophore receptor AWN88_07245 ENOG4105J76 Periplasmic binding protein AWN88_07260 ENOG4107QN2 dihydrolipoyl dehydrogenase AWN88_07285 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AWN88_07290 ENOG4106TD9 Diguanylate cyclase AWN88_07300 ENOG4105RQF LysR family Transcriptional regulator AWN88_07310 ENOG4105F38 ABC transporter, permease AWN88_07315 ENOG4105D38 putrescine abc transporter AWN88_07320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_07325 ENOG4105E1J oxidoreductase AWN88_07345 ENOG4107R73 Mate efflux family protein AWN88_07370 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AWN88_07375 ENOG4105BZ9 Cytochrome C oxidase, subunit I AWN88_07390 ENOG4105E98 transcriptional regulator DeoR family AWN88_07395 ENOG4105WQI isochorismatase AWN88_07400 ENOG4105D38 putrescine abc transporter AWN88_07405 ENOG4105F38 ABC transporter, permease AWN88_07410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_07420 ENOG4105CHR reductase AWN88_07425 ENOG4108JPW Aminotransferase AWN88_07440 ENOG4105CEB Aspartate aminotransferase AWN88_07455 ENOG4105CPC Aldo Keto reductase AWN88_07465 ENOG410642W LysR family Transcriptional regulator AWN88_07480 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AWN88_07485 ENOG4105C7W Xanthine dehydrogenase AWN88_07490 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AWN88_07495 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AWN88_07500 ENOG4107XAN XdhC and CoxI family AWN88_07505 ENOG4108SGK Tetr family transcriptional regulator AWN88_07510 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AWN88_07530 ENOG4105CC0 LysR family Transcriptional regulator AWN88_07535 ENOG4105EUB pirin domain protein AWN88_07540 ENOG4105CHJ isochorismatase hydrolase AWN88_07545 ENOG410903D sensor protein AWN88_07580 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AWN88_07590 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AWN88_07605 ENOG4105BZU Histidine kinase AWN88_07615 ENOG4105BZU Histidine kinase AWN88_07620 ENOG41074H6 response regulator AWN88_07625 ENOG4105BZU Histidine kinase AWN88_07630 ENOG4107QQR Sporulation AWN88_07645 ENOG4107QZ7 Cellulose synthase catalytic subunit AWN88_07655 ENOG4105DRS transport system, permease AWN88_07675 ENOG4105F7P transcriptional regulator AsnC family AWN88_07680 ENOG4105C28 cystathionine AWN88_07690 ENOG4105F04 LysR family Transcriptional regulator AWN88_07695 ENOG4105C7F AcnD-accessory protein PrpF AWN88_07710 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AWN88_07720 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_07725 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AWN88_07745 ENOG4105FKQ transcriptional regulator AWN88_07750 ENOG4105PF9 Transcriptional regulator AWN88_07755 ENOG4105C1P efflux transporter, rnd family, mfp subunit AWN88_07765 ENOG4105BZS acriflavin resistance protein AWN88_07775 ENOG41073TP transcriptional regulator AWN88_07780 ENOG4108IJ0 Aspartate ammonia-lyase AWN88_07790 ENOG4105HDK L-asparaginase AWN88_07800 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AWN88_07805 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) AWN88_07810 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) AWN88_07815 ENOG4105C08 Histidine kinase AWN88_07825 ENOG4105C5W Aldolase AWN88_07840 ENOG4106F60 Histidine kinase AWN88_07855 ENOG4105CVE Lytic murein transglycosylase AWN88_07875 ENOG4105C2X Arabinose 5-phosphate isomerase AWN88_07885 ENOG4107QX8 SPFH domain, Band 7 family protein AWN88_07890 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AWN88_07895 ENOG4105CGH 5'-nucleotidase AWN88_07900 ENOG4105ZWB Outer membrane lipoprotein AWN88_07905 ENOG4105FE5 Homospermidine synthase AWN88_07910 ENOG4105BZU Histidine kinase AWN88_07915 ENOG4107Z5F Aminotransferase class IV AWN88_07920 ENOG4105DPN Oligoendopeptidase f AWN88_07925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AWN88_07930 ENOG4105EAQ (twin-arginine translocation) pathway signal AWN88_07935 ENOG4105CA9 Pyruvate kinase AWN88_07955 ENOG4105Y2X UPF0335 protein AWN88_07960 ENOG4105M0T TPR Repeat-Containing Protein AWN88_07965 ENOG4105YK5 50S ribosomal protein L36 AWN88_07970 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AWN88_07975 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AWN88_08000 ENOG4105ECY inositol monophosphatase AWN88_08010 ENOG4105UYK outer membrane protein a AWN88_08020 ENOG4105BZ1 (ABC) transporter AWN88_08025 ENOG41082FS 50S ribosomal protein L31 AWN88_08045 ENOG4107R1Y fructose-bisphosphate aldolase AWN88_08050 ENOG4105BZA Phosphoglycerate kinase AWN88_08090 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AWN88_08095 ENOG4105D48 metallophosphoesterase AWN88_08110 ENOG4105CDY transcriptional regulatory protein AWN88_08115 ENOG4105DEN Luciferase family AWN88_08120 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AWN88_08125 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AWN88_08130 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AWN88_08145 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AWN88_08155 ENOG4107YD3 Thioesterase AWN88_08160 ENOG4105E02 MotA TolQ exbB proton channel AWN88_08165 ENOG4105SG9 biopolymer transport protein, ExbD AWN88_08175 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) AWN88_08180 ENOG4105KCK Peptidoglycan-associated lipoprotein AWN88_08190 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AWN88_08195 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWN88_08200 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AWN88_08215 ENOG4108JQ1 Dehydrogenase AWN88_08235 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AWN88_08260 ENOG4105K63 Thioredoxin AWN88_08270 ENOG4105W49 UPF0434 protein AWN88_08275 ENOG4105DN3 alpha-2-macroglobulin domain protein AWN88_08280 ENOG4108JQB penicillin-binding protein 1C AWN88_08300 ENOG4105DZ1 carboxypeptidase AWN88_08305 ENOG4105CKI cobalamin synthesis protein AWN88_08310 ENOG4105VFE sira family AWN88_08315 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AWN88_08320 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AWN88_08325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AWN88_08335 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AWN88_08340 ENOG4105D49 3-dehydroquinate synthase AWN88_08375 ENOG4105EX9 Membrane AWN88_08380 ENOG4105KDC 50s ribosomal protein l28 AWN88_08395 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AWN88_08400 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWN88_08405 ENOG4105CIH Imidazole acetol-phosphate transaminase AWN88_08420 ENOG4108NH8 Cation transport protein AWN88_08440 ENOG4105CAK Cell division ATP-binding protein ftsE AWN88_08450 ENOG4108UGV hypoxanthine phosphoribosyltransferase AWN88_08465 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AWN88_08475 ENOG4105CH7 arginosuccinase AWN88_08480 ENOG4107ZT5 Thiol disulfide interchange protein AWN88_08485 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AWN88_08490 ENOG4105C10 Electron transfer flavoprotein AWN88_08495 ENOG4105BZJ Electron transfer flavoprotein AWN88_08505 ENOG4108WBT adenosyltransferase AWN88_08515 ENOG4105E1F short-chain dehydrogenase reductase AWN88_08525 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AWN88_08535 ENOG4105CFF transcriptional regulator AWN88_08540 ENOG4107QX3 carboxylase AWN88_08545 ENOG4105CYM Glutathione S-transferase AWN88_08575 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AWN88_08585 ENOG4105DFW ABC transporter AWN88_08590 ENOG4107RNG ABC transporter AWN88_08595 ENOG4105C2J ABC transporter AWN88_08605 ENOG4108WRK Transcriptional regulator AWN88_08670 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AWN88_08675 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AWN88_08680 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AWN88_08765 ENOG4105KVH Transcriptional regulator AWN88_08795 ENOG4105FDR Membrane AWN88_08800 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AWN88_08805 ENOG4105EIN peptidylprolyl cis-trans isomerase AWN88_08810 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AWN88_08815 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AWN88_08820 ENOG4105M6F mutator MutT protein AWN88_08830 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AWN88_08835 ENOG4105MJ2 Competence protein AWN88_08840 ENOG4105VW4 glutaredoxin 3 AWN88_08855 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AWN88_08870 ENOG4108IPT Naphthoate synthase AWN88_08875 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AWN88_08880 ENOG4108I5D sulfate abc transporter AWN88_08885 ENOG4105ECW sulfate abc transporter AWN88_08890 ENOG4108IJ6 ABC transporter AWN88_08895 ENOG4105F1N DNA alkylation repair AWN88_08915 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AWN88_08930 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AWN88_08935 ENOG4105CNN ABC, transporter AWN88_08940 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AWN88_08945 ENOG4105C2J ABC transporter AWN88_08955 ENOG4105E98 transcriptional regulator DeoR family AWN88_08965 ENOG4105C9F isomerase AWN88_08970 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AWN88_08975 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AWN88_08980 ENOG4105CGU Enoyl-CoA hydratase AWN88_08985 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AWN88_08995 ENOG4107QX3 carboxylase AWN88_09000 ENOG4105C1G acyl-Coa dehydrogenase AWN88_09005 ENOG4105J0Q Transcriptional regulator AWN88_09010 ENOG4105C1G acyl-Coa dehydrogenase AWN88_09015 ENOG4107R0V Pyruvate dehydrogenase AWN88_09020 ENOG4105CPP Dehydrogenase, E1 component AWN88_09025 ENOG4107QSN dihydrolipoamide acetyltransferase AWN88_09030 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AWN88_09035 ENOG4105KFG YeeE YedE family protein AWN88_09045 ENOG41080HT Transcriptional regulator, arsr family AWN88_09050 ENOG4107S76 domain protein AWN88_09060 ENOG4108UU4 oxidoreductase (Short chain dehydrogenase reductase family) AWN88_09075 ENOG4105JXH GntR family transcriptional regulator AWN88_09085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_09095 ENOG4105C3U ABC transporter AWN88_09100 ENOG4108JQ7 (ABC) transporter AWN88_09105 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_09115 ENOG4105DIA mandelate racemase muconate lactonizing AWN88_09120 ENOG4108M8W Monooxygenase AWN88_09145 ENOG4105FBW Monooxygenase AWN88_09150 ENOG4105CH2 amidohydrolase AWN88_09155 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_09165 ENOG4105E43 Extracellular solute-binding protein, family 5 AWN88_09170 ENOG4105CPU Monooxygenase AWN88_09175 ENOG4105ETT transcriptional Regulator, LysR family AWN88_09185 ENOG4105CPC Aldo Keto reductase AWN88_09220 ENOG4105C1G acyl-Coa dehydrogenase AWN88_09240 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AWN88_09245 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AWN88_09255 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family AWN88_09260 ENOG4105DEN Luciferase family AWN88_09270 ENOG4105CH2 amidohydrolase AWN88_09285 ENOG4105CDA abc transporter atp-binding protein AWN88_09290 ENOG4105EAB amino acid AbC transporter AWN88_09300 ENOG4108DN8 FAD dependent oxidoreductase AWN88_09305 ENOG4108RYR transcriptional regulator AsnC family AWN88_09315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_09335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AWN88_09350 ENOG4105CJP fad dependent oxidoreductase AWN88_09365 ENOG41067RQ csbd family AWN88_09370 ENOG4105WH1 Two component transcriptional regulator luxr family AWN88_09395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_09400 ENOG4105F38 ABC transporter, permease AWN88_09405 ENOG4105D38 putrescine abc transporter AWN88_09410 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AWN88_09420 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AWN88_09445 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWN88_09465 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AWN88_09470 ENOG4105C2J ABC transporter AWN88_09475 ENOG4105CNN ABC, transporter AWN88_09480 ENOG4105CNN ABC, transporter AWN88_09485 ENOG4105ETE Transcriptional regulator (LacI family AWN88_09520 ENOG4105DUM transcriptional regulator, lysR family AWN88_09565 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AWN88_09570 ENOG4108UZX fmn reductase AWN88_09580 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AWN88_09590 ENOG4108JQ6 ABC transporter AWN88_09595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_09605 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_09620 ENOG4105CQB FAD linked oxidase domain protein AWN88_09640 ENOG4108DBC nitroreductase AWN88_09655 ENOG4107T8P acyl-Coa dehydrogenase AWN88_09660 ENOG4105C6T cysteine synthase AWN88_09670 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AWN88_09685 ENOG4108TSE Transferase AWN88_09690 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AWN88_09695 ENOG4105WQI isochorismatase AWN88_09700 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AWN88_09705 ENOG4105E4F Isochorismate synthase AWN88_09715 ENOG4105C0W non-ribosomal peptide synthetase AWN88_09720 ENOG4105CEY Amp-dependent synthetase and ligase AWN88_09730 ENOG4105Q26 Siderophore-interacting protein AWN88_09740 ENOG4108IHU transport system permease protein AWN88_09745 ENOG4105DQ5 transport system permease protein AWN88_09750 ENOG4105E0A ABC, transporter AWN88_09755 ENOG4105CPU Monooxygenase AWN88_09765 ENOG4107RBR Receptor AWN88_09770 ENOG4105C1G acyl-Coa dehydrogenase AWN88_09775 ENOG4105ETT transcriptional Regulator, LysR family AWN88_09780 ENOG4105ETE Transcriptional regulator (LacI family AWN88_09790 ENOG4105F38 ABC transporter, permease AWN88_09800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_09810 ENOG4105CPN adenine deaminase AWN88_09820 ENOG4105CH2 amidohydrolase AWN88_09825 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AWN88_09830 ENOG4108IGT Dipeptidase AWN88_09835 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_09840 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_09845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_09850 ENOG4105C3U ABC transporter AWN88_09855 ENOG4108JQ7 (ABC) transporter AWN88_09860 ENOG4108M0I Transcriptional regulator AWN88_09865 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_09875 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_09880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AWN88_09885 ENOG4107R7Y intracellular protease Pfpi family AWN88_09895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_09905 ENOG4107QSI ABC, transporter AWN88_09910 ENOG4105CH2 amidohydrolase AWN88_09915 ENOG4108JQ6 ABC transporter AWN88_09920 ENOG4105DKT Transcriptional regulator AWN88_09940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_09945 ENOG4105DEI Mannitol dehydrogenase AWN88_09950 ENOG4107YBY Hydrolase AWN88_09955 ENOG4105EF1 ribulokinase AWN88_09980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AWN88_09985 ENOG4105DKT Transcriptional regulator AWN88_09990 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AWN88_09995 ENOG4107258 Transcriptional regulator AWN88_10000 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AWN88_10005 ENOG4105CC5 ABC transporter AWN88_10010 ENOG4105CC5 ABC transporter AWN88_10015 ENOG4105DIK (ABC) transporter AWN88_10020 ENOG4105DSE periplasmic solute binding protein AWN88_10030 ENOG4105CRK lysyL-tRNA synthetase AWN88_10035 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AWN88_10050 ENOG4105EE5 Membrane protein terC AWN88_10055 ENOG4105J7D transcriptional regulator AWN88_10075 ENOG4105CMG Carbohydrate kinase AWN88_10080 ENOG4105C93 Xylose Isomerase AWN88_10090 ENOG4108RCM Nitroreductase AWN88_10095 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AWN88_10100 ENOG4108UMI ABC transporter, permease AWN88_10105 ENOG4105D01 (LipO)protein AWN88_10110 ENOG4105BZU Histidine kinase AWN88_10115 ENOG4105C72 UPF0176 protein AWN88_10125 ENOG41080ZE Adenylate cyclase AWN88_10130 ENOG4108UHU Aldolase AWN88_10150 ENOG4105D7X high-affinity nickel-transporter AWN88_10190 ENOG4105CKI cobalamin synthesis protein AWN88_10200 ENOG4107MII Sugar-specific transcriptional regulator TrmB AWN88_10205 ENOG4105ETE Transcriptional regulator (LacI family AWN88_10210 ENOG4105C5I Dehydrogenase AWN88_10220 ENOG4105DH8 myo-inositol catabolism AWN88_10230 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AWN88_10235 ENOG4105EDK PfkB domain protein AWN88_10245 ENOG4108IV0 ABC, transporter AWN88_10250 ENOG4105C0Z ABC transporter AWN88_10265 ENOG4105CAD extracellular ligand-binding receptor AWN88_10280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_10290 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AWN88_10315 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AWN88_10320 ENOG4107S9B Shikimate dehydrogenase AWN88_10325 ENOG4105CDA abc transporter atp-binding protein AWN88_10330 ENOG4105CT1 (ABC) transporter AWN88_10335 ENOG4105E5Q amino acid AbC transporter AWN88_10340 ENOG4105E5Q amino acid AbC transporter AWN88_10345 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AWN88_10350 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha AWN88_10355 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta AWN88_10360 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase AWN88_10370 ENOG4105DDW LysR family Transcriptional regulator AWN88_10375 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase AWN88_10385 ENOG4107HP6 Transcriptional regulator AWN88_10395 ENOG4107QNJ CoA-transferase subunit B AWN88_10400 ENOG4105CHU acetyl-coa acetyltransferase AWN88_10405 ENOG4105ETE Transcriptional regulator (LacI family AWN88_10420 ENOG4105F0H myo-inositol catabolism protein AWN88_10425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AWN88_10435 ENOG4105ETE Transcriptional regulator (LacI family AWN88_10440 ENOG4105DG4 malate L-lactate dehydrogenase AWN88_10445 ENOG4105BZU Histidine kinase AWN88_10455 ENOG4105S0E allantoin catabolism protein AWN88_10460 ENOG4105BZU Histidine kinase AWN88_10465 ENOG4105C1P efflux transporter, rnd family, mfp subunit AWN88_10470 ENOG4105BZS acriflavin resistance protein AWN88_10485 ENOG4105CNN ABC, transporter AWN88_10490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AWN88_10495 ENOG4105CC0 LysR family Transcriptional regulator AWN88_10540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_10545 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AWN88_10550 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AWN88_10555 ENOG4108IJG ABC transporter substrate-binding protein AWN88_10560 ENOG4105CKI cobalamin synthesis protein AWN88_10575 ENOG4105CKI cobalamin synthesis protein AWN88_10580 ENOG4105DIK (ABC) transporter AWN88_10585 ENOG4105CC5 ABC transporter AWN88_10590 ENOG4105DSE periplasmic solute binding protein AWN88_10595 ENOG4105ETE Transcriptional regulator (LacI family AWN88_10610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWN88_10615 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AWN88_10625 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_10630 ENOG4105W8I Transcriptional regulator AWN88_10635 ENOG4105EU0 Major facilitator Superfamily AWN88_10670 ENOG4105CPC Aldo Keto reductase AWN88_10685 ENOG4105JXH GntR family transcriptional regulator AWN88_10690 ENOG4105E9Z Nad-dependent epimerase dehydratase AWN88_10695 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) AWN88_10700 ENOG4105CHR reductase AWN88_10705 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AWN88_10710 ENOG4105CXK mandelate racemase muconate lactonizing AWN88_10715 ENOG4105GAK amidohydrolase 2 AWN88_10720 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AWN88_10730 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_10740 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AWN88_10745 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AWN88_10750 ENOG4108IJ9 (ABC) transporter AWN88_10765 ENOG4107XII Glycosyl Hydrolase Family 88 AWN88_10770 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AWN88_10775 ENOG4105FAT Acyl-transferase AWN88_10795 ENOG4105K5G 30S ribosomal protein S21 AWN88_10810 ENOG4105DDC Oxidoreductase domain protein AWN88_10830 ENOG4108W9H Tetr family transcriptional regulator AWN88_10835 ENOG4105BZ7 extracellular solute-binding protein family 1 AWN88_10840 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AWN88_10845 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AWN88_10850 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_10870 ENOG4108JQ1 Dehydrogenase AWN88_10880 ENOG4105ETE Transcriptional regulator (LacI family AWN88_10910 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AWN88_10915 ENOG4105DRS transport system, permease AWN88_10920 ENOG4108SNK aliphatic sulfonates import ATP-binding protein SsuB AWN88_10925 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AWN88_10930 ENOG4105GVF (ABC) transporter AWN88_10940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_10945 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AWN88_10950 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AWN88_10970 ENOG4107SDU Methyl-accepting chemotaxis AWN88_10990 ENOG41073TP transcriptional regulator AWN88_10995 ENOG4108HW3 (ABC) transporter AWN88_11000 ENOG4105E5Q amino acid AbC transporter AWN88_11005 ENOG4105E5Q amino acid AbC transporter AWN88_11015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_11025 ENOG4105F38 ABC transporter, permease AWN88_11030 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AWN88_11045 ENOG4105ETT transcriptional Regulator, LysR family AWN88_11050 ENOG41066YJ Beta-lactamase AWN88_11055 ENOG4105C2W permease AWN88_11060 ENOG4107QIJ Aconitate hydratase 2 AWN88_11075 ENOG4105EQK -acetyltransferase AWN88_11105 ENOG4105Q95 Cupin 2, conserved barrel domain protein AWN88_11190 ENOG4105CQ0 ABC transporter AWN88_11195 ENOG4105CQ0 ABC transporter AWN88_11305 ENOG4105EPW hflc protein AWN88_11350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_11355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_11360 ENOG4105C3U ABC transporter AWN88_11370 ENOG4105DEF Extracellular solute-binding protein, family 5 AWN88_11380 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AWN88_11385 ENOG4105C7B Threonine dehydratase AWN88_11395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AWN88_11400 ENOG4105HEI LysR family (Transcriptional regulator AWN88_11410 ENOG4105CGH 5'-nucleotidase AWN88_11435 ENOG4105KHC sulfurtransferase AWN88_11450 ENOG4105CVP deoxyribo-dipyrimidine photolyase AWN88_11460 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AWN88_11490 ENOG4108TPP exopolysaccharide synthesis AWN88_11495 ENOG4108UM1 dedA family AWN88_11540 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase AWN88_11565 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) AWN88_11575 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AWN88_11580 ENOG4105CYW agmatinase AWN88_11585 ENOG4108UJD 30S ribosomal protein S9 AWN88_11590 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AWN88_11600 ENOG4105K4P CoA-binding domain protein AWN88_11620 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AWN88_11625 ENOG4106A3M Cytochrome p-450 AWN88_11635 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWN88_11640 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AWN88_11645 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AWN88_11675 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AWN88_11680 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWN88_11685 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AWN88_11695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWN88_11705 ENOG4105GKE subunit e AWN88_11710 ENOG4107QIZ NADH dehydrogenase AWN88_11715 ENOG4107R0R NADH dehydrogenase subunit g AWN88_11720 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AWN88_11725 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWN88_11730 ENOG4105DF2 NADH dehydrogenase subunit j AWN88_11735 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWN88_11740 ENOG4105D65 subunit l AWN88_11745 ENOG4105C8S subunit m AWN88_11750 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AWN88_11755 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AWN88_11770 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AWN88_11780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AWN88_11785 ENOG4105C0B DNA polymerase III (alpha subunit) AWN88_11795 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AWN88_11805 ENOG4108UXN response regulator AWN88_11810 ENOG4105BZU Histidine kinase AWN88_11815 ENOG4105W0E 50S ribosomal protein L33 AWN88_11820 ENOG4108ISG Major Facilitator AWN88_11835 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AWN88_11850 ENOG4105C79 DNA protecting protein DprA AWN88_11855 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AWN88_11860 ENOG4105CD3 dihydroorotase AWN88_11865 ENOG4105CXT aspartate transcarbamylase AWN88_11870 ENOG4105CSU acyl-Coa dehydrogenase AWN88_11875 ENOG4108ZBR Gcn5-related n-acetyltransferase AWN88_11890 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AWN88_11895 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AWN88_11900 ENOG4107T8T UPF0173 metal-dependent hydrolase AWN88_11905 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AWN88_11910 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AWN88_11915 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AWN88_11920 ENOG4105YCT UPF0386 protein AWN88_11935 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AWN88_11945 ENOG410849A acetyltransferase, (GNAT) family AWN88_11960 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AWN88_11965 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AWN88_11970 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AWN88_11975 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AWN88_11980 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AWN88_12005 ENOG4105CHR reductase AWN88_12010 ENOG4105C03 ribonuclease AWN88_12015 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AWN88_12025 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AWN88_12040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AWN88_12045 ENOG4105JAB phenazine biosynthesis protein, phzf family AWN88_12060 ENOG4107Z7P Ferredoxin AWN88_12075 ENOG4105KRF dihydroneopterin aldolase AWN88_12080 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AWN88_12090 ENOG4106K28 UPF0283 membrane protein AWN88_12095 ENOG4105CM6 amino acid regulated cytosolic protein AWN88_12105 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AWN88_12120 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AWN88_12155 ENOG4105K59 histidine triad (HIT) protein AWN88_12180 ENOG4105CE9 30S ribosomal protein S2 AWN88_12185 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AWN88_12190 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AWN88_12195 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AWN88_12200 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AWN88_12205 ENOG4105KNE Phosphatidate cytidylyltransferase AWN88_12210 ENOG4105DZP Membrane-associated zinc metalloprotease AWN88_12215 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AWN88_12220 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWN88_12225 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AWN88_12230 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWN88_12235 ENOG4105GYT Protein of unknown function (DUF1009) AWN88_12240 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWN88_12245 ENOG4105BZN citrate synthase AWN88_12260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AWN88_12285 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AWN88_12290 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AWN88_12300 ENOG4108JYK Dehydrogenase AWN88_12305 ENOG4105CPP Dehydrogenase, E1 component AWN88_12310 ENOG4105C7S Dehydrogenase AWN88_12320 ENOG4107QN2 dihydrolipoyl dehydrogenase AWN88_12330 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AWN88_12335 ENOG4105DXC membrane AWN88_12350 ENOG4108Z1B Cyclase dehydrase AWN88_12360 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AWN88_12370 ENOG4105CUX Signal transduction histidine kinase AWN88_12375 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AWN88_12380 ENOG4105ES5 Histidine kinase AWN88_12385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AWN88_12390 ENOG4105C1A potassium transporter peripheral membrane AWN88_12395 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AWN88_12400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AWN88_12435 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AWN88_12445 ENOG4105CPC Aldo Keto reductase AWN88_12460 ENOG4105NXV High-affinity zinc uptake system protein AWN88_12465 ENOG4105FDK ABC transporter AWN88_12470 ENOG4105FAV ABC, transporter AWN88_12480 ENOG4108Z0R Transferase AWN88_12485 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AWN88_12490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AWN88_12500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AWN88_12505 ENOG4108UUM single-stranded DNA-binding protein AWN88_12510 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AWN88_12515 ENOG41081FY multiple antibiotic resistance (MarC)-related AWN88_12520 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AWN88_12565 ENOG4105DZ1 carboxypeptidase AWN88_12570 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AWN88_12575 ENOG4107QRG dna polymerase iii AWN88_12580 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AWN88_12585 ENOG4105F8V Hydrolase, tatD family AWN88_12590 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AWN88_12610 ENOG4107MKT Stringent starvation protein a AWN88_12615 ENOG4105D3R alkyl hydroperoxide reductase AWN88_12625 ENOG4108UPT UPF0178 protein AWN88_12635 ENOG4105C4W S-formylglutathione hydrolase AWN88_12640 ENOG4108UQ8 endoribonuclease L-psp AWN88_12655 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AWN88_12660 ENOG4105EI2 Pseudouridine synthase AWN88_12665 ENOG41082CG Protein CrcB homolog AWN88_12690 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AWN88_12695 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AWN88_12700 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AWN88_12725 ENOG4105DP0 ferredoxin-NADP reductase AWN88_12745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AWN88_12755 ENOG4105DXN mazG family AWN88_12800 ENOG4105CJW magnesium transporter AWN88_12805 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AWN88_12815 ENOG4108XEG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AWN88_12825 ENOG4105BZU Histidine kinase AWN88_12835 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AWN88_12840 ENOG4105DQ4 alcohol dehydrogenase AWN88_12880 ENOG4105E2A Dehydrogenase AWN88_12900 ENOG4105D7W serine acetyltransferase AWN88_12905 ENOG4105D74 hydrolase AWN88_12915 ENOG4105MSY salicylate hydroxylase AWN88_12920 ENOG4105C28 cystathionine AWN88_12925 ENOG4107QXX ABC transporter AWN88_12930 ENOG4105EZ7 amino acid ABC transporter AWN88_12935 ENOG4105DRP amino acid AbC transporter AWN88_12940 ENOG4105CDA abc transporter atp-binding protein AWN88_12955 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AWN88_12965 ENOG4105D6E homoserine dehydrogenase AWN88_12970 ENOG4105CHM Aminotransferase AWN88_13000 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AWN88_13010 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AWN88_13015 ENOG4105J3Q acyl carrier protein AWN88_13020 ENOG4105D4P Coproporphyrinogen iii oxidase AWN88_13025 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AWN88_13035 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class AWN88_13040 ENOG4105PW4 Sugar fermentation stimulation protein homolog AWN88_13045 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AWN88_13050 ENOG4105W5Q DNA repair protein (RadC AWN88_13065 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase AWN88_13085 ENOG4105E66 phosphoriboisomerase A AWN88_13090 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AWN88_13100 ENOG4105C9Q fumarate hydratase class II AWN88_13105 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AWN88_13110 ENOG4107EJC Preprotein translocase subunit SecG AWN88_13115 ENOG4105CP7 Triose-phosphate isomerase AWN88_13125 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AWN88_13130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWN88_13140 ENOG4105KBH arsR family transcriptional regulator AWN88_13145 ENOG4107RZC phospholipase d AWN88_13160 ENOG4105EGS Mechanosensitive ion channel AWN88_13215 ENOG4105DHJ ABC, transporter AWN88_13220 ENOG4105CY3 ABC transporter, permease AWN88_13225 ENOG4107S8C mandelate racemase muconate lactonizing AWN88_13235 ENOG4105C6K Malic enzyme AWN88_13240 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase AWN88_13250 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase AWN88_13255 ENOG4108MR6 WD40-like Beta Propeller Repeat AWN88_13265 ENOG4105C4K Nad synthetase AWN88_13270 ENOG4107T7U Sulfatase AWN88_13300 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AWN88_13310 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AWN88_13330 ENOG4107QPD alcohol dehydrogenase AWN88_13360 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AWN88_13365 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AWN88_13370 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AWN88_13375 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AWN88_13380 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AWN88_13395 ENOG4108I0Q anthranilate phosphoribosyltransferase AWN88_13400 ENOG4105DK0 Indole-3-glycerol phosphate synthase AWN88_13405 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AWN88_13410 ENOG4105CVM Molybdenum cofactor synthesis domain protein AWN88_13415 ENOG4105BZU Histidine kinase AWN88_13425 ENOG4105CKD glutathione-regulated potassium-efflux system protein AWN88_13435 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AWN88_13445 ENOG4105CZQ inner membrane transport protein YdhC AWN88_13450 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AWN88_13455 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AWN88_13460 ENOG4105DR5 peptidase AWN88_13465 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AWN88_13470 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AWN88_13475 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AWN88_13480 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AWN88_13490 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AWN88_13495 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AWN88_13500 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AWN88_13505 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) AWN88_13515 ENOG4105C75 arginyL-tRNA synthetase AWN88_13520 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AWN88_13525 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AWN88_13535 ENOG4108UQD Sel1 domain protein repeat-containing protein AWN88_13545 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AWN88_13555 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AWN88_13575 ENOG4105CS1 NAD(P)H quinone oxidoreductase AWN88_13580 ENOG4107TH8 cina domain protein AWN88_13590 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AWN88_13595 ENOG4107RTZ reductase AWN88_13610 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AWN88_13625 ENOG4105BZ1 (ABC) transporter AWN88_13630 ENOG4105IPI Membrane AWN88_13665 ENOG4105C22 threonyL-tRNA synthetase AWN88_13675 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) AWN88_13685 ENOG4105EUJ GTP cyclohydrolase i AWN88_13690 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AWN88_13695 ENOG4105D78 K07001 NTE family protein AWN88_13700 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AWN88_13730 ENOG4105EJQ L-serine dehydratase AWN88_13770 ENOG4105ECQ AraC Family Transcriptional Regulator AWN88_13775 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AWN88_13785 ENOG4105C5F glutamine synthetase AWN88_13795 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) AWN88_13815 ENOG4105DFI Membrane AWN88_13835 ENOG4105CB5 ATP-dependent DNA helicase recG AWN88_13865 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AWN88_13870 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AWN88_13875 ENOG4107EJG GntR family transcriptional regulator AWN88_13890 ENOG4105UIB (ABC) transporter AWN88_13895 ENOG4105C2J ABC transporter AWN88_13900 ENOG4105VE1 Phosphatidylcholine synthase AWN88_13905 ENOG41061H0 Monooxygenase AWN88_13910 ENOG4105RK9 auxin efflux carrier AWN88_13915 ENOG4107QIV Cytochrome c biogenesis protein AWN88_13940 ENOG4105VEQ Cold shock protein AWN88_13995 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AWN88_14310 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AWN88_14315 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AWN88_14330 ENOG4105QAS Iron-sulfur cluster assembly accessory protein AWN88_14335 ENOG4105VG1 fes assembly suf system protein AWN88_14345 ENOG4105JRK feS assembly protein SufD AWN88_14365 ENOG4105C3J Cysteine desulfurase AWN88_14370 ENOG4105DHZ alpha beta AWN88_14375 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AWN88_14380 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AWN88_14390 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AWN88_14395 ENOG4105ED9 Protein of unknown function (DUF455) AWN88_14400 ENOG4105DR5 peptidase AWN88_14405 ENOG4105C1J atp-dependent rna helicase AWN88_14420 ENOG4105DJV ribulose-phosphate 3-epimerase AWN88_14430 ENOG4105C83 adenylosuccinate lyase AWN88_14440 ENOG4107QPR SAICAR synthetase AWN88_14445 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AWN88_14450 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I AWN88_14465 ENOG4107SQD Transcriptional regulator, GntR family AWN88_14475 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AWN88_14500 ENOG4105C2C drug resistance transporter, Bcr CflA AWN88_14505 ENOG4105ECY inositol monophosphatase AWN88_14510 ENOG4108MWI inositol mono-phosphatase AWN88_14515 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AWN88_14520 ENOG4105CSV Glutaminase AWN88_14525 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AWN88_14530 ENOG4105DU1 integral membrane protein, terc AWN88_14540 ENOG4108594 Permease of the drug metabolite transporter AWN88_14545 ENOG410829K Lysine exporter protein (Lyse ygga) AWN88_14555 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AWN88_14560 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AWN88_14580 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AWN88_14590 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AWN88_14595 ENOG4107UH8 sugar kinase AWN88_14600 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AWN88_14610 ENOG4106TNF Periplasmic binding protein AWN88_14615 ENOG4105GBT ABC transporter AWN88_14625 ENOG4105P0T Usg family AWN88_14635 ENOG4105GVF (ABC) transporter AWN88_14640 ENOG4108XM1 transcriptional regulator AsnC family AWN88_14645 ENOG4108RG0 uracil-dna glycosylase AWN88_14655 ENOG4105BZU Histidine kinase AWN88_14665 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AWN88_14670 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AWN88_14685 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AWN88_14690 ENOG4105E3A (ABC) transporter AWN88_14695 ENOG4105DA5 (ABC) transporter AWN88_14710 ENOG4105C8Q Methyl-accepting chemotaxis AWN88_14720 ENOG4105D1H recombination factor protein RarA AWN88_14725 ENOG4105C0H protease AWN88_14740 ENOG4105C01 Dihydroxy-acid dehydratase AWN88_14745 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) AWN88_14750 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AWN88_14755 ENOG4108ZT0 50S ribosomal protein l17 AWN88_14760 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWN88_14765 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AWN88_14770 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AWN88_14775 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AWN88_14780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AWN88_14785 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AWN88_14790 ENOG41084HQ 50S ribosomal protein L30 AWN88_14795 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AWN88_14800 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AWN88_14805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AWN88_14810 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AWN88_14815 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AWN88_14820 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AWN88_14825 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AWN88_14830 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AWN88_14835 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AWN88_14840 ENOG41083MP 50s ribosomal protein l29 AWN88_14845 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AWN88_14850 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AWN88_14855 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AWN88_14860 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AWN88_14865 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AWN88_14870 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AWN88_14875 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AWN88_14880 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AWN88_14890 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AWN88_14895 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AWN88_14900 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AWN88_14905 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AWN88_14925 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWN88_14930 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AWN88_14935 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AWN88_14940 ENOG4108VZM 50s ribosomal protein L10 AWN88_14945 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AWN88_14950 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AWN88_14970 ENOG4105C5E polysaccharide biosynthesis protein AWN88_14975 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AWN88_14980 ENOG4108ZCF integral membrane protein AWN88_15010 ENOG4105C2N RNA methyltransferase TrmH family group 3 AWN88_15015 ENOG4105NAU thioesterase Superfamily protein AWN88_15030 ENOG4108RYK Nad-dependent epimerase dehydratase AWN88_15050 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AWN88_15060 ENOG4105DYC esterase AWN88_15065 ENOG4105CB5 ATP-dependent DNA helicase recG AWN88_15080 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWN88_15105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_15110 ENOG4105E0C molybdate abc transporter AWN88_15115 ENOG4107QKW extracellular solute-binding protein family 1 AWN88_15120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AWN88_15125 ENOG4105NWF RbsD or FucU transport AWN88_15135 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AWN88_15145 ENOG4105CF7 AraC family transcriptional regulator AWN88_15150 ENOG4105DQ4 alcohol dehydrogenase AWN88_15155 ENOG4105CEP NADH dehydrogenase AWN88_15160 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AWN88_15170 ENOG4107SID ATP-dependent exodnase (exonuclease v) AWN88_15195 ENOG4105CV8 reductase AWN88_15210 ENOG4108ZP8 Acetolactate synthase small subunit AWN88_15215 ENOG4105C7K acetolactate synthase AWN88_15225 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AWN88_15230 ENOG4105EAC phosphoserine phosphatase AWN88_15235 ENOG4108YYQ gCN5-related N-acetyltransferase AWN88_15240 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AWN88_15250 ENOG4105EPW hflc protein AWN88_15255 ENOG4107QJR hflk protein AWN88_15260 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AWN88_15265 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AWN88_15300 ENOG4105CQB FAD linked oxidase domain protein AWN88_15305 ENOG4105BZS acriflavin resistance protein AWN88_15310 ENOG4105ENT Efflux transporter rnd family, mfp subunit AWN88_15345 ENOG4108RWI nicotinamidase AWN88_15370 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AWN88_15375 ENOG4108ZX6 Electron transport protein SCO1 SenC AWN88_15380 ENOG4108V3W Chemotaxis protein, CheW AWN88_15390 ENOG41083X2 DNA polymerase III, epsilon subunit AWN88_15395 ENOG4105ETT transcriptional Regulator, LysR family AWN88_15405 ENOG4105WCN acetyltransferase AWN88_15415 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AWN88_15420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AWN88_15425 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AWN88_15430 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AWN88_15435 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AWN88_15440 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AWN88_15445 ENOG4108UFP Essential cell division protein (By similarity) AWN88_15450 ENOG4105CPF Cell wall formation (By similarity) AWN88_15455 ENOG4105CSH Transporter AWN88_15460 ENOG4105D4A Cell wall formation (By similarity) AWN88_15465 ENOG4105DFU Cell wall formation (By similarity) AWN88_15470 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AWN88_15480 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AWN88_15485 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AWN88_15495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AWN88_15510 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AWN88_15515 ENOG4107YUR Cell division protein mraZ AWN88_15540 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AWN88_15545 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AWN88_15570 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AWN88_15585 ENOG4105SYT Methylenetetrahydrofolate reductase AWN88_15600 ENOG4105E5G Alpha beta hydrolase fold AWN88_15605 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AWN88_15620 ENOG4105M4H endoribonuclease L-psp AWN88_15635 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AWN88_15640 ENOG4105EQ0 Major Facilitator superfamily AWN88_15660 ENOG4105C26 Dehydrogenase AWN88_15665 ENOG4105C5F glutamine synthetase AWN88_15670 ENOG4105CUB amino acid AWN88_15680 ENOG4105QEK Transcriptional regulator AWN88_15690 ENOG4106SMU thiamine transporter membrane protein AWN88_15700 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_15720 ENOG4105C3R Methionine synthase AWN88_15725 ENOG4107QKS N-acylglucosamine 2-epimerase AWN88_15755 ENOG4105MPN Membrane AWN88_15770 ENOG4105BZU Histidine kinase AWN88_15780 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWN88_15785 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AWN88_15805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AWN88_15810 ENOG4107QI1 Mate efflux family protein AWN88_15815 ENOG4105C8Q Methyl-accepting chemotaxis AWN88_15825 ENOG4105CGZ zinc metallopeptidase AWN88_15840 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AWN88_15850 ENOG4105BZU Histidine kinase AWN88_15855 ENOG4108UN4 phage SPO1 DNA polymerase-related protein AWN88_15865 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AWN88_15875 ENOG4105F7P transcriptional regulator AsnC family AWN88_15880 ENOG4105C3M thioredoxin reductase AWN88_15885 ENOG4105CBN LysR family transcriptional regulator AWN88_15895 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AWN88_15925 ENOG4105CHM Aminotransferase AWN88_15950 ENOG4105C5X domain protein AWN88_15960 ENOG41090HR transcriptional regulator AWN88_15965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AWN88_15970 ENOG4105E0F Histidine kinase AWN88_15975 ENOG4108Z7R Chaperone CsaA AWN88_15980 ENOG4105II7 pyrroline-5-carboxylate reductase AWN88_15995 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AWN88_16005 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AWN88_16020 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AWN88_16030 ENOG4107G9V glycosyl transferase, family 39 AWN88_16040 ENOG4105CKK Glycosyl transferase, family 2 AWN88_16050 ENOG4105C26 Dehydrogenase AWN88_16055 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AWN88_16060 ENOG4105BZU Histidine kinase AWN88_16065 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AWN88_16080 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AWN88_16090 ENOG4105M74 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AWN88_16095 ENOG4105C3G gtp-binding protein AWN88_16110 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AWN88_16115 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AWN88_16125 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AWN88_16135 ENOG4105BZ1 (ABC) transporter AWN88_16140 ENOG4105BZ1 (ABC) transporter AWN88_16150 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AWN88_16155 ENOG4105EAM Na Pi-cotransporter AWN88_16165 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) AWN88_16180 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AWN88_16185 ENOG4105P8F nudix hydrolase AWN88_16195 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AWN88_16215 ENOG4105VEV -acetyltransferase AWN88_16230 ENOG41079KZ Major Facilitator Superfamily AWN88_16240 ENOG4105CHF Glutathione S-transferase AWN88_16255 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AWN88_16270 ENOG4105DKK Benzoate AWN88_16295 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWN88_16310 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AWN88_16335 ENOG41080HT Transcriptional regulator, arsr family AWN88_16340 ENOG4108IJ7 Glycine betaine AWN88_16355 ENOG4107104 thymidine kinase AWN88_16375 ENOG4108TEB UPF0114 protein AWN88_16390 ENOG4105CRQ synthase (Component I) AWN88_16400 ENOG4105CPI Metal Dependent Phosphohydrolase AWN88_16405 ENOG4105CPN adenine deaminase AWN88_16420 ENOG4105CG3 alpha amylase, catalytic region AWN88_16425 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AWN88_16440 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AWN88_16470 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AWN88_16490 ENOG4105C7W Xanthine dehydrogenase AWN88_16500 ENOG4105ETT transcriptional Regulator, LysR family AWN88_16515 ENOG4107QUY Guanine deaminase AWN88_16525 ENOG4105DMF Dehydrogenase AWN88_16535 ENOG4108RZE Tetr family transcriptional regulator AWN88_16540 ENOG4105DZ1 carboxypeptidase AWN88_16555 ENOG4108Z2U ureidoglycolate hydrolase AWN88_16580 ENOG4108TXN phosphonate metabolism protein AWN88_16585 ENOG41087SS fad dependent oxidoreductase AWN88_16590 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AWN88_16595 ENOG4105BZU Histidine kinase AWN88_16600 ENOG4105C1J atp-dependent rna helicase AWN88_16610 ENOG4105MGM doxx family AWN88_16615 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AWN88_16655 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AWN88_16665 ENOG4108HWW ABC transporter AWN88_16675 ENOG4105DFW ABC transporter AWN88_16750 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AWN88_16770 ENOG4108Z18 K06886 hemoglobin AWN88_16790 ENOG4108R86 Transcriptional regulator AWN88_16795 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AWN88_16800 ENOG4105CD3 dihydroorotase AWN88_16805 ENOG4105M6F mutator MutT protein AWN88_16815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AWN88_16820 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AWN88_16845 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AWN88_16850 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AWN88_16855 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AWN88_16860 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AWN88_16875 ENOG4105CQM Urea amidohydrolase subunit alpha AWN88_16880 ENOG4106ISJ urease accessory protein AWN88_16885 ENOG4105VTN Protein of unknown function (DUF1311) AWN88_16895 ENOG4105KI2 Urea amidohydrolase subunit beta AWN88_16900 ENOG4105XDF Protein of unknown function (DUF1272) AWN88_16905 ENOG4108YZ9 Urea amidohydrolase subunit gamma AWN88_16910 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AWN88_16920 ENOG4108IV0 ABC, transporter AWN88_16925 ENOG4105C0Z ABC transporter AWN88_16935 ENOG4105C32 Amino acid ABC transporter (Permease) AWN88_16955 ENOG4105CHR reductase AWN88_16960 ENOG4105BZU Histidine kinase AWN88_16965 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase AWN88_16975 ENOG4108ZJ4 polysaccharide deacetylase AWN88_16990 ENOG4108IV0 ABC, transporter AWN88_16995 ENOG4105C0Z ABC transporter AWN88_17000 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AWN88_17005 ENOG4105C32 Amino acid ABC transporter (Permease) AWN88_17010 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AWN88_17040 ENOG4105EFQ Two component transcriptional regulator (Winged helix family AWN88_17095 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWN88_17105 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AWN88_17130 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AWN88_17140 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AWN88_17145 ENOG4107XDR Lactoylglutathione lyase AWN88_17150 ENOG4105WD1 Membrane AWN88_17155 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AWN88_17160 ENOG4105EHG Permease protein AWN88_17165 ENOG4107R4I Periplasmic binding protein AWN88_17175 ENOG41090JE Utilization Protein AWN88_17195 ENOG4108TAG Histidine kinase AWN88_17235 ENOG4105DHS permease protein AWN88_17240 ENOG4105CM4 permease protein AWN88_17245 ENOG4108IPW abc transporter atp-binding protein AWN88_17250 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AWN88_17265 ENOG4105CV8 reductase AWN88_17270 ENOG4105F27 Major Facilitator AWN88_17275 ENOG4105EXG Transcriptional regulator AWN88_17280 ENOG4105CC0 LysR family Transcriptional regulator AWN88_17290 ENOG4105ENT Efflux transporter rnd family, mfp subunit AWN88_17310 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AWN88_17320 ENOG4107B2H carbonic anhydrase AWN88_17330 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AWN88_17340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWN88_17345 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AWN88_17350 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) AWN88_17355 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) AWN88_17360 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AWN88_17365 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) AWN88_17370 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) AWN88_17375 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) AWN88_17380 ENOG4108YNN Heme oxygenase AWN88_17385 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_17405 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_17415 ENOG4108MGF sugar kinase AWN88_17425 ENOG4105F0I Aminotransferase AWN88_17430 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AWN88_17440 ENOG4108JQ7 (ABC) transporter AWN88_17450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_17455 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_17460 ENOG4108J59 Extracellular solute-binding protein, family 5 AWN88_17465 ENOG4108IGT Dipeptidase AWN88_17505 ENOG4105DHQ Histidine kinase AWN88_17525 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_17555 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AWN88_17575 ENOG4105EW9 transcriptional regulator AsnC family AWN88_17580 ENOG4105CHJ isochorismatase hydrolase AWN88_17585 ENOG4105JQN Transcriptional regulator AWN88_17595 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AWN88_17600 ENOG41090HZ type iii secretion AWN88_17640 ENOG4105C8V SAICAR synthetase AWN88_17650 ENOG4105C1P efflux transporter, rnd family, mfp subunit AWN88_17655 ENOG4105BZS acriflavin resistance protein AWN88_17665 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AWN88_17670 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AWN88_17675 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AWN88_17695 ENOG4105CJP fad dependent oxidoreductase AWN88_17700 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AWN88_17705 ENOG4105E0C molybdate abc transporter AWN88_17710 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AWN88_17715 ENOG4105F4R Transcriptional regulator mode AWN88_17725 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AWN88_17740 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AWN88_17745 ENOG410609C Acyl carrier protein AWN88_17775 ENOG4105BZ1 (ABC) transporter AWN88_17780 ENOG410870F Cyclic nucleotide-binding protein AWN88_17785 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AWN88_17800 ENOG4107QQG Dehydrogenase AWN88_17825 ENOG4107QSI ABC, transporter AWN88_17830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AWN88_17835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AWN88_17845 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AWN88_17855 ENOG4106N3A copper homeostasis protein cutc AWN88_17860 ENOG4105S8Q sugar efflux transporter AWN88_17870 ENOG4105E2D ec 3.2.1.52 AWN88_17880 ENOG4106KNT transcriptional regulator AWN88_17890 ENOG4108IJ9 (ABC) transporter AWN88_17900 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AWN88_17915 ENOG4105FDP GntR family transcriptional regulator AWN88_17925 ENOG4105CE4 GlcNAc 6-P deacetylase AWN88_17930 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AWN88_17940 ENOG4105YVM Phosphoesterase, PA-phosphatase related AWN88_17945 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AWN88_17950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AWN88_17960 ENOG4105CFU surface antigen AWN88_17970 ENOG4108V3W Chemotaxis protein, CheW AWN88_17975 ENOG4107SDU Methyl-accepting chemotaxis AWN88_17980 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AWN88_17985 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AWN88_17990 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AWN88_17995 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AWN88_18000 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AWN88_18005 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWN88_18015 ENOG4105C25 Primosomal protein n' AWN88_18020 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AWN88_18025 ENOG4105MBR gumn family AWN88_18040 ENOG4107QN2 dihydrolipoyl dehydrogenase AWN88_18045 ENOG4105N14 lysine exporter protein LysE YggA AWN88_18055 ENOG4105C7S Dehydrogenase AWN88_18065 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AWN88_18070 ENOG4105CMV Succinyl-CoA synthetase subunit beta AWN88_18075 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AWN88_18080 ENOG4105D6Z AFG1 family ATPase AWN88_18085 ENOG4105YU5 Outer membrane lipoprotein AWN88_18090 ENOG4105E33 succinate dehydrogenase AWN88_18095 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AWN88_18105 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) AWN88_18110 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AWN88_18125 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AWN88_18130 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AWN88_18135 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AWN88_18160 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AWN88_18175 ENOG410856B UPF0235 protein AWN88_18180 ENOG4105F0N pyrophosphate phospho-hydrolase AWN88_18195 ENOG4105DGW oligopeptidase A AWN88_18205 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) AWN88_18210 ENOG4105C0R drug resistance transporter emrb qaca subfamily AWN88_18215 ENOG4105CDH Citrulline--aspartate ligase AWN88_18225 ENOG410829K Lysine exporter protein (Lyse ygga) AWN88_18230 ENOG4108JJB ABC transporter AWN88_18235 ENOG4105C7J ABC transporter, permease AWN88_18245 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AWN88_18260 ENOG4105KZX Pterin carbinolamine dehydratase AWN88_18265 ENOG4105KJF protein tyrosine phosphatase AWN88_18270 ENOG4105M7V 2'-5' rna ligase AWN88_18280 ENOG4108I0Y (ABC) transporter AWN88_18290 ENOG4105HFZ Membrane AWN88_18305 ENOG4107QM5 aconitate hydratase AWN88_18310 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AWN88_18315 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AWN88_18320 ENOG41060IM Heme exporter protein AWN88_18335 ENOG4106TD9 Diguanylate cyclase AWN88_18340 ENOG4108VRQ UPF0314 protein AWN88_18345 ENOG4107835 probably involved in intracellular septation (By similarity) AWN88_18350 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AWN88_18355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AWN88_18360 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) AWN88_18370 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AWN88_18375 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AWN88_18380 ENOG4105K5M 30s ribosomal protein S16 AWN88_18385 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AWN88_18390 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AWN88_18400 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AWN88_18410 ENOG4108HW4 amino acid AbC transporter AWN88_18420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AWN88_18425 ENOG4105ERG peptidase m48, ste24p AWN88_18430 ENOG4107T0D ABC, transporter AWN88_18450 ENOG4105C5H ABC transporter AWN88_18460 ENOG4105CVG Homoserine O-transsuccinylase AWN88_18465 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AWN88_18470 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AWN88_18475 ENOG4105CTB Polyprenyl synthetase AWN88_18480 ENOG4108ZG0 Ompa motb domain protein AWN88_18485 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AWN88_18490 ENOG4106UW1 Major Facilitator superfamily AWN88_18495 ENOG4105MVE transcriptional regulator AWN88_18500 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AWN88_18505 ENOG4105WH1 Two component transcriptional regulator luxr family AWN88_18510 ENOG4105BZ1 (ABC) transporter AWN88_18520 ENOG4105E2V Glycosyltransferase 36 AWN88_18525 ENOG4105CH2 amidohydrolase AWN88_18530 ENOG4105D5U fad dependent oxidoreductase AWN88_18540 ENOG4105C01 Dihydroxy-acid dehydratase AWN88_18545 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AWN88_18550 ENOG4105EXW epimerase dehydratase AWN88_18555 ENOG4105CQB FAD linked oxidase domain protein AWN88_18560 ENOG4107YCY Transcriptional regulator AWN88_18570 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AWN88_18575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AWN88_18580 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AWN88_18585 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AWN88_18595 ENOG4105DFA alanine racemase domain protein AWN88_18600 ENOG4105C8T Leucyl-tRNA synthetase AWN88_18615 ENOG4108Z4U Ferredoxin AWN88_18620 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AWN88_18635 ENOG4105C29 acyl-CoA thioesterase AWN88_18640 ENOG4108YZA Nitrogen regulatory protein pii AWN88_18645 ENOG4105BZU Histidine kinase AWN88_18650 ENOG4105CNU cell division protein FtsK AWN88_18655 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) AWN88_18670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWN88_18680 ENOG4108VJ1 Transcriptional regulator (CarD family AWN88_18685 ENOG4105C7I Dehydrogenase AWN88_18690 ENOG4105DEU major facilitator superfamily AWN88_18705 ENOG4105CHR reductase AWN88_18730 ENOG4105CN1 protease AWN88_18740 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AWN88_18750 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AWN88_18755 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AWN88_18760 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AWN88_18765 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AWN88_18780 ENOG4105K46 50S ribosomal protein l27 AWN88_18785 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AWN88_18810 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AWN88_18815 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AWN88_18825 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AWN88_18830 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AWN88_18835 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AWN88_18895 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AWN88_18900 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AWN88_18910 ENOG4105EFT decarboxylase AWN88_18915 ENOG4105DIA mandelate racemase muconate lactonizing AWN88_18920 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AWN88_18930 ENOG4105CPQ Dehydrogenase AWN88_18950 ENOG4107RNG ABC transporter AWN88_18955 ENOG4105C2J ABC transporter AWN88_18960 ENOG4107YCY Transcriptional regulator AWN88_18965 ENOG4105CTX dehydratase AWN88_18970 ENOG4105DC1 bifunctional purine biosynthesis protein purh AWN88_18980 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AWN88_18985 ENOG4105D0M Protease HtpX homolog AWN88_18995 ENOG4105FA0 parb-like partition protein AWN88_19000 ENOG4107QJE Chromosome Partitioning Protein AWN88_19005 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) AWN88_19010 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AWN88_19015 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AWN88_19020 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AWN88_19025 ENOG4108YXA Membrane AWN88_19030 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AWN88_19035 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AWN88_19040 ENOG4108UHJ MAF-like protein AWN88_19045 ENOG4105E2X shikimate dehydrogenase AWN88_19050 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AWN88_19055 ENOG4107RZZ dna polymerase iii epsilon subunit AWN88_19060 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AWN88_19075 ENOG4105CA3 membrane-bound lytic murein transglycosylase AWN88_19090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AWN88_19100 ENOG4105ERH Fumarylacetoacetate hydrolase AWN88_19115 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AWN88_19120 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AWN88_19125 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AWN88_19130 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) AWN88_19145 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AWN88_19155 ENOG4108S0S Nucleotidyl transferase AWN88_19160 ENOG4105EHM Aminoglycoside phosphotransferase AWN88_19165 ENOG4105I8F Histidine kinase AWN88_19170 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) AWN88_19175 ENOG41080Z8 PHOSPHOCARRIER protein AWN88_19180 ENOG4108EQA pts system AWN88_19185 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AWN88_19190 ENOG4105EB3 Histidine kinase AWN88_19195 ENOG4105E3W Two component transcriptional regulator (Winged helix family AWN88_19200 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AWN88_19205 ENOG4108YZN class I peptide chain release factor AWN88_19210 ENOG4109066 lysm domain bon superfamily protein AWN88_19215 ENOG4105CS9 pantothenic acid kinase AWN88_19220 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase AWN88_19225 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AWN88_19230 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AWN88_19235 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AWN88_19245 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AWN88_19250 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AWN88_19255 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AWN88_19265 ENOG4107QP3 malate synthase g AWN88_19280 ENOG4108UYB regulatoR AWN88_19285 ENOG4105TX3 Histidine kinase AWN88_19290 ENOG4105CQ7 ATP-dependent helicase AWN88_19350 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AWN88_19365 ENOG4105DZ2 Transcriptional regulator AWN88_19370 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AWN88_19375 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AWN88_19380 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AWN88_19485 ENOG4105E4C Lytic transglycosylase catalytic AWN88_19520 ENOG4105DP0 ferredoxin-NADP reductase AWN88_19530 ENOG4108Z4X TRANSCRIPTIONal AWN88_19565 ENOG4107U9B transcriptional regulator AWN88_19570 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AWN88_19580 ENOG4105MHT Transcriptional regulator, ARSR family AWN88_19595 ENOG4105CNM Receptor AWN88_19610 ENOG4105DQ5 transport system permease protein AWN88_19615 ENOG4105TVJ transport system, permease AWN88_19620 ENOG4105E0A ABC, transporter AWN88_19635 ENOG4105E0K tonB-dependent siderophore receptor AWN88_19650 ENOG4105DQ5 transport system permease protein AWN88_19655 ENOG4105TVJ transport system, permease AWN88_19755 ENOG4105VFE sira family AWN88_19760 ENOG4105CNU cell division protein FtsK AWN88_19765 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AWN88_19785 ENOG4105EQR Transposase IS116 IS110 IS902 AWN88_19825 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AWN88_19835 ENOG4105VCH membrane AWN88_19860 ENOG4107MKT Stringent starvation protein a AWN88_19865 ENOG4105EQ0 Major Facilitator superfamily AWN88_19870 ENOG4108IND Tetr family transcriptional regulator AWN88_19895 ENOG4105CC0 LysR family Transcriptional regulator AWN88_19915 ENOG4107SCK Monooxygenase AWN88_19920 ENOG41062ES Transcriptional regulator AWN88_19925 ENOG4108JU3 Alkyl hydroperoxide reductase AWN88_19940 ENOG4105C9U ATP-dependent DNA helicase RecQ AWN88_19950 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator AWN88_19955 ENOG4105CNN ABC, transporter AWN88_19960 ENOG4105C2J ABC transporter AWN88_19965 ENOG4105CS9 pantothenic acid kinase AWN88_19970 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AWN88_19975 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AWN88_19995 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AWN88_20030 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AWN88_20035 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AWN88_20040 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AWN88_20045 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AWN88_20050 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AWN88_20055 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AWN88_20070 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AWN88_20075 ENOG4107SFI Major Facilitator superfamily AWN88_20080 ENOG4105CVE Lytic murein transglycosylase AWN88_20085 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AWN88_20095 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AWN88_20100 ENOG4107QMP dna polymerase iii subunits gamma and tau AWN88_20115 ENOG4105E09 nadh pyrophosphatase AWN88_20120 ENOG4105CQC Prephenate dehydratase AWN88_20125 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AWN88_20130 ENOG4105G9V cytochrome C AWN88_20140 ENOG4108JQC penicillin-binding protein 1A AWN88_20145 ENOG4108UIN ybak prolyl-trna synthetase associated region AWN88_20155 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AWN88_20165 ENOG4105C2M dna polymerase I AWN88_20175 ENOG41082R8 50S ribosomal protein l32 AWN88_20180 ENOG4105CQZ Histidine kinase AWN88_20185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AWN88_20205 ENOG41069P5 Protein slyX homolog AWN88_20215 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) AWN88_20220 ENOG4105CFG Acts as a chaperone (By similarity) AWN88_20235 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AWN88_20240 ENOG4105DIH basic membrane AWN88_20245 ENOG4108JQ9 ABC transporter AWN88_20260 ENOG4105KG3 cytidine deaminase AWN88_20265 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AWN88_20270 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) AWN88_20275 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AWN88_20285 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AWN88_20290 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) AWN88_20295 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AWN88_20305 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AWN88_20310 ENOG4105CCU oxidase (Subunit III) AWN88_20315 ENOG4105BZ9 Cytochrome C oxidase, subunit I AWN88_20320 ENOG4105E2S oxidase) subunit II AWN88_20325 ENOG4105CSH Transporter AWN88_20330 ENOG4105CBC glutamate synthase AWN88_20335 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AWN88_20350 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AWN88_20360 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) AWN88_20370 ENOG4105EN6 Membrane AWN88_20390 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AWN88_20410 ENOG4108ZZF transport protein (ExbD) AWN88_20420 ENOG4105DG4 malate L-lactate dehydrogenase AWN88_20435 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AWN88_20440 ENOG4105FD8 phosphonate metabolism protein PhnM AWN88_20445 ENOG4108TXN phosphonate metabolism protein AWN88_20455 ENOG4105S7S phosphonate abc transporter AWN88_20460 ENOG4105EHI Phosphonate ABC transporter, periplasmic AWN88_20465 ENOG4105D5T phosphonate abc transporter AWN88_20475 ENOG4105HRV phosphonate c-p lyase system protein phnl AWN88_20480 ENOG4105ENV phosphonate C-P lyase system protein PhnK AWN88_20510 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AWN88_20515 ENOG4105CHC glucokinase (EC 2.7.1.2) AWN88_20520 ENOG4108Z5K methylglyoxal synthase AWN88_20525 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) AWN88_20535 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AWN88_20540 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AWN88_20545 ENOG4108JQ5 ABC transporter AWN88_20550 ENOG4105MWK D-amino acid dehydrogenase, small subunit AWN88_20555 ENOG4105CFQ glutamine synthetase AWN88_20560 ENOG4105CJP fad dependent oxidoreductase AWN88_20565 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AWN88_20570 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AWN88_20575 ENOG4108IJ8 ABC transporter AWN88_20580 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AWN88_20585 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AWN88_20595 ENOG4105KPV Transcriptional regulator AWN88_20605 ENOG4105C26 Dehydrogenase AWN88_20615 ENOG4108JHT EamA-like transporter family AWN88_20630 ENOG4107SN7 NLP P60 protein AWN88_20635 ENOG4107RH7 Nicotinate phosphoribosyltransferase AWN88_20640 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AWN88_20720 ENOG4105KWI UPF0339 protein AWN88_20725 ENOG4108UQ1 hydrolase, family 25 AWN88_20730 ENOG4105T38 integral membrane protein AWN88_20735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AWN88_20765 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AWN88_20770 ENOG4105ES4 Nitrilase AWN88_20800 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AWN88_20805 ENOG4105CH5 extracellular solute-binding protein, family 7 AWN88_20830 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AWN88_20835 ENOG41082BR 50S ribosomal protein L35 AWN88_20840 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AWN88_20850 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AWN88_20855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AWN88_20860 ENOG4105CPC Aldo Keto reductase AWN88_20865 ENOG4105EQ2 LysR family Transcriptional regulator AWN88_20905 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AWN88_20910 ENOG4105CXK mandelate racemase muconate lactonizing AWN88_20920 ENOG4108ZT1 Transcriptional regulator AWN88_20925 ENOG4108KTG Membrane protein, drug metabolite transporter AWN88_20930 ENOG4105C88 aminopeptidase AWN88_20935 ENOG4108Z66 YbaK ebsC protein AWN88_20940 ENOG4105KUZ arsenate reductase AWN88_20960 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) AWN88_20975 ENOG4105KAV tspo and mbr like protein AWN88_21000 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AWN88_21005 ENOG4105K6T rare lipoprotein A AWN88_21015 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AWN88_21025 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AWN88_21040 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AWN88_21055 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AWN88_21060 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AWN88_21065 ENOG41082FP UPF0102 protein AWN88_21075 ENOG4105BZ7 extracellular solute-binding protein family 1 AWN88_21090 ENOG4108IJ9 (ABC) transporter AWN88_21100 ENOG4105D7Z glutathione synthase AWN88_21105 ENOG4105C0P Mg chelatase subunit ChlI AWN88_21120 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AWN88_21125 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AWN88_21130 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AWN88_21145 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) AWN88_21150 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWN88_21155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AWN88_21160 ENOG4105E39 Enoyl-CoA hydratase AWN88_21165 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) AWN88_21170 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AWN88_21175 ENOG4105CSA Coproporphyrinogen iii oxidase AWN88_21180 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AWN88_21185 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AWN88_21190 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AWN88_21195 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AWN88_21200 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AWN88_21205 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea AWN88_21210 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AWN88_21215 ENOG4108IUZ ABC transporter AWN88_21220 ENOG4105RF0 OstA family AWN88_21230 ENOG4105D07 Signal peptide peptidase, SppA AWN88_21235 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AWN88_21245 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AWN88_21250 ENOG4108RWN rrna methyltransferase AWN88_21255 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AWN88_21260 ENOG4105BZU Histidine kinase AWN88_21270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AWN88_21275 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AWN88_21280 ENOG4105CJR Integral membrane protein (MviN AWN88_21290 ENOG4105C31 Tryptophanyl-tRNA synthetase AWN88_21300 ENOG41083MR nifu domain-containing protein AWN88_21305 ENOG41072GX Peptidase M22 Glycoprotease AWN88_21310 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AWN88_21315 ENOG41090R7 Ferric uptake AWN88_21320 ENOG4108Z20 Acyl-transferase AWN88_21325 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AWN88_21330 ENOG4105C9A Phoh family AWN88_21335 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AWN88_21345 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AWN88_21350 ENOG4108WRK Transcriptional regulator AWN88_21355 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AWN88_21360 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AWN88_21365 ENOG4108RVA ribokinase AWN88_21370 ENOG4105CGY Dna recombination protein AWN88_21375 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AWN88_21380 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AWN88_21385 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AWN88_21395 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AWN88_21400 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AWN88_21420 ENOG4108ZNX Heat shock protein AWN88_21445 ENOG4105CAS nag kinase AWN88_21455 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AWN88_21460 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AWN88_21465 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AWN88_21490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AWN88_21495 ENOG4108IJ9 (ABC) transporter AWN88_21500 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AWN88_21505 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AWN88_21520 ENOG4105CYC Transferase AWN88_21530 ENOG4105CTU Proline racemase AWN88_21535 ENOG4105EKE dihydroorotase AWN88_21540 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AWN88_21560 ENOG4105DBV ornithine carbamoyltransferase AWN88_21565 ENOG4107QP8 phosphohexose isomerase AWN88_21570 ENOG4105CEY Amp-dependent synthetase and ligase AWN88_21575 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_21580 ENOG4107QKW extracellular solute-binding protein family 1 AWN88_21585 ENOG4107Z6A sulfate abc transporter permease AWN88_21590 ENOG4105E0K tonB-dependent siderophore receptor AWN88_21670 ENOG4105CSR polyphosphate kinase 2 AWN88_21675 ENOG4105BZU Histidine kinase AWN88_21680 ENOG4105PWN phosphate abc transporter AWN88_21685 ENOG4105C8U phosphate abc transporter AWN88_21695 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AWN88_21700 ENOG4108UTW Plays a role in the regulation of phosphate uptake AWN88_21705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWN88_21715 ENOG4105C8Y Acetylornithine aminotransferase AWN88_21720 ENOG4105DBV ornithine carbamoyltransferase AWN88_21725 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AWN88_21730 ENOG4105NWN ApaG protein AWN88_21740 ENOG4105DHP deoxycytidine triphosphate deaminase AWN88_21750 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AWN88_21800 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) AWN88_21815 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AWN88_21835 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AWN88_21840 ENOG4107QRT dEAD DEAH box helicase AWN88_21870 ENOG4105CSU acyl-Coa dehydrogenase AWN88_21875 ENOG4105CHU acetyl-coa acetyltransferase AWN88_21880 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AWN88_21900 ENOG4105KJM monovalent cation h antiporter subunit g AWN88_21905 ENOG4105W4C monovalent cation H antiporter subunit F AWN88_21910 ENOG4105SC1 monovalent cation H antiporter subunit E AWN88_21915 ENOG4107R4Z monovalent cation h antiporter subunit d AWN88_21920 ENOG4108ZE9 Monovalent cation H antiporter subunit C AWN88_21925 ENOG4105D65 subunit l AWN88_21935 ENOG4105UT3 Methyl-accepting chemotaxis AWN88_21945 ENOG4108VYJ response regulator receiver protein AWN88_21950 ENOG4105CBS Chea signal transduction histidine kinase AWN88_21955 ENOG4105BZU Histidine kinase AWN88_21960 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AWN88_21965 ENOG4108VYJ response regulator receiver protein AWN88_21970 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) AWN88_21980 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AWN88_21985 ENOG4105VJY transcriptional regulator AWN88_22000 ENOG4105BZU Histidine kinase AWN88_22005 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AWN88_22010 ENOG4105CHM Aminotransferase AWN88_22025 ENOG41086Q3 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AWN88_22030 ENOG4108Z03 MAF-like protein AWN88_22035 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AWN88_22045 ENOG4108ZTZ UPF0262 protein AWN88_22050 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AWN88_22060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AWN88_22090 ENOG4105CN7 Flagellar biosynthetic protein FliP AWN88_22100 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AWN88_22110 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AWN88_22115 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA AWN88_22120 ENOG4105CGA flagellar basal-body rod protein FlgG AWN88_22125 ENOG4105X50 flagellar hook-basal body complex protein fliE AWN88_22130 ENOG4108ZC9 flagellar basal-body rod protein flgc AWN88_22135 ENOG4105SFI flagellar basal-body rod protein AWN88_22145 ENOG4108JIR Flagellum-specific ATP synthase AWN88_22150 ENOG4105KTQ flagellar basal-body rod protein AWN88_22160 ENOG4107RD7 Flagellar Motor Protein, MotA AWN88_22170 ENOG4105DD5 Flagellar motor switch protein AWN88_22175 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AWN88_22180 ENOG4105D00 flagellar biosynthetic protein flhB AWN88_22185 ENOG4105QDQ AWN88_22190 ENOG4107W75 Flagellin AWN88_22200 ENOG4105ER2 Ompa motb domain protein AWN88_22205 ENOG4108S15 chemotaxis, protein AWN88_22225 ENOG4105BZE flagellar hook protein, FlgE AWN88_22245 ENOG4105KHD Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation (By similarity) AWN88_22250 ENOG410822I Flagellar hook capping protein AWN88_22255 ENOG4105VS8 Flagellar biosynthetic protein fliq AWN88_22260 ENOG4105D7B Flagellar biosynthesis protein flha AWN88_22265 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AWN88_22300 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AWN88_22305 ENOG4105FKQ transcriptional regulator AWN88_22310 ENOG4105EPJ extracellular solute-binding protein family 1 AWN88_22315 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component AWN88_22320 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component AWN88_22325 ENOG4105CG3 alpha amylase, catalytic region AWN88_22330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_22345 ENOG4105C01 Dihydroxy-acid dehydratase AWN88_22350 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) AWN88_22355 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AWN88_22360 ENOG4105CJP fad dependent oxidoreductase AWN88_22370 ENOG4105CBX hi0933 family AWN88_22410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AWN88_22415 ENOG4105F38 ABC transporter, permease AWN88_22420 ENOG4105D38 putrescine abc transporter AWN88_22430 ENOG4105BZU Histidine kinase AWN88_22460 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AWN88_22730 ENOG4105C9X ppx gppa phosphatase AWN88_22735 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AWN88_22740 ENOG4105C0R drug resistance transporter emrb qaca subfamily AWN88_22770 ENOG4108RIR Molybdenum cofactor biosynthesis protein AWN88_22775 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AWN88_22785 ENOG4105EAH synthase AWN88_22795 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) AWN88_22815 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AWN88_22825 ENOG4108V0P LemA family AWN88_22830 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AWN88_22840 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AWN88_22845 ENOG4105VUH addiction module killer protein AWN88_22865 ENOG4105C12 Phosphoribosylglycinamide synthetase AWN88_22870 ENOG4105BZM domain protein AWN88_22875 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AWN88_22885 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AWN88_22920 ENOG4105CJ3 phosphate transporter AWN88_22930 ENOG4108E2B had-superfamily hydrolase, subfamily iib AWN88_22935 ENOG4107STW synthase AWN88_22940 ENOG4105C6F GntR Family Transcriptional Regulator AWN88_22950 ENOG410642W LysR family Transcriptional regulator AWN88_22955 ENOG4105CQB FAD linked oxidase domain protein AWN88_22960 ENOG4105EU8 FAD linked oxidase domain protein AWN88_22965 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AWN88_22975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AWN88_22980 ENOG4108R3E Dna-3-methyladenine glycosylase i AWN88_22990 ENOG4105HMI Membrane AWN88_22995 ENOG4108M0I Transcriptional regulator AWN88_23025 ENOG4105CUT histidyl-tRNA synthetase AWN88_23035 ENOG4105P5X ATP phosphoribosyltransferase regulatory subunit AWN88_23040 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AWN88_23045 ENOG4108SB3 DoxX Family AWN88_23055 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AWN88_23060 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AWN88_23070 ENOG4105DTN riboflavin biosynthesis protein ribF AWN88_23075 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AWN88_23085 ENOG4108Z6B deaminase AWN88_23090 ENOG4105FE9 pseudouridine synthase AWN88_23095 ENOG4106H78 methyltransferase AWN88_23100 ENOG4105D78 K07001 NTE family protein AWN88_23105 ENOG4105CKD glutathione-regulated potassium-efflux system protein AWN88_23110 ENOG4105CMS peptidase U62, modulator of DNA gyrase AWN88_23115 ENOG4107TK4 histidinol-phosphate phosphatase AWN88_23125 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AWN88_23135 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AWN88_23145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AWN88_23150 ENOG4105BZU Histidine kinase AWN88_23155 ENOG4105BZU Histidine kinase AWN88_23160 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AWN88_23165 ENOG4108RTU Aldolase AWN88_23170 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 AWN88_23175 ENOG4105FGE Short-chain dehydrogenase reductase Sdr AWN88_23180 ENOG4105J4Q Transcriptional regulator AWN88_23185 ENOG4107WYG Transcriptional regulator, luxr family AWN88_23190 ENOG4105I5W Transporter AWN88_23195 ENOG4105D1F ATP-binding protein AWN88_23200 ENOG4107QUT magnesium and cobalt transport protein CorA AWN88_23205 ENOG4105DFH Transport of potassium into the cell (By similarity) AWN88_23215 ENOG4107PQ6 Inherit from NOG: atp synthase AWN88_23220 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AWN88_23225 ENOG4105VD1 ATP synthase subunit C AWN88_23230 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AWN88_23250 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AWN88_23270 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AWN88_23280 ENOG4105DVW rieske (2Fe-2S) AWN88_23295 ENOG4105W6J BA14K family AWN88_23305 ENOG4105CSU acyl-Coa dehydrogenase AWN88_23320 ENOG4107QS4 23S rRNA AWN88_23340 ENOG4105FKN transcriptional regulator, AsnC family AWN88_23365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AWN88_23370 ENOG4105EUB pirin domain protein AWN88_23375 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AWN88_23385 ENOG4107ZYJ bioY protein AWN88_23390 ENOG4107QCX Transporter AWN88_23395 ENOG4108JJB ABC transporter AWN88_23400 ENOG4105T0Z Conserved Protein AWN88_23405 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AWN88_23410 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AWN88_23425 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AWN88_23440 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) AWN88_23455 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AWN88_23465 ENOG4105D1U peptidase U62 modulator of DNA gyrase AWN88_23475 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) AWN88_23480 ENOG4105BZ9 Cytochrome C oxidase, subunit I AWN88_23485 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AWN88_23490 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) AWN88_23495 ENOG4107QS1 Cytochrome C Oxidase, Subunit III AWN88_23505 ENOG4108R6F Surfeit locus 1 family protein AWN88_23510 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AWN88_23515 ENOG4105CUV Homoserine Kinase AWN88_23520 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AWN88_23530 ENOG4105EHV domain protein AWN88_23540 ENOG4108UJU UPF0301 protein AWN88_23555 ENOG4105BZU Histidine kinase AWN88_23560 ENOG4105D9U N-acetyltransferase AWN88_23565 ENOG4105C1V Peptidase, M16 AWN88_23570 ENOG4105D98 threonine synthase AWN88_23580 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AWN88_23585 ENOG4108PVQ transcriptional regulator AWN88_23600 ENOG4105CEC DNA methylase N-4 N-6 AWN88_23605 ENOG4105YAJ CopG Arc MetJ AWN88_23620 ENOG4105CEN a g-specific adenine glycosylase AWN88_23630 ENOG4108R9S DSBA oxidoreductase AWN88_23635 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AWN88_23640 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AWN88_23645 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AWN88_23660 ENOG4108ETY sodium dicarboxylate symporter AWN88_23685 ENOG4105DWT malate dehydrogenase (quinone) AWN88_23705 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AWN88_23710 ENOG4105C11 sulfate adenylyltransferase), subunit 2 AWN88_23715 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AWN88_23720 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family AWN88_23725 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AWN88_23730 ENOG4108I5D sulfate abc transporter AWN88_23740 ENOG4108IJ6 ABC transporter AWN88_23750 ENOG4108NJZ Sensory box GGDEF EAL domain protein AWN88_23755 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AWN88_23760 ENOG4105C26 Dehydrogenase AWN88_23765 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AWN88_23800 ENOG4107MKT Stringent starvation protein a AWN88_23810 ENOG4105C0R drug resistance transporter emrb qaca subfamily AWN88_23820 ENOG4107T0X DNA ligase AWN88_23830 ENOG4108ST3 glycosyltransferase AWN88_23840 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AWN88_23845 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AWN88_23850 ENOG4105K56 Transcriptional regulator AWN88_23855 ENOG4108ZHJ Organic hydroperoxide resistance protein AWN88_23870 ENOG4105C5H ABC transporter AWN88_23900 ENOG4105EQ2 LysR family Transcriptional regulator AWN88_23905 ENOG4105EMU Dehydrogenase AWN88_23920 ENOG4105D7A ATP-binding protein AWN88_23930 ENOG4105KVH Transcriptional regulator AWN88_23935 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AWN88_23945 ENOG410829K Lysine exporter protein (Lyse ygga) AWN88_23950 ENOG4105CV8 reductase AWN88_23955 ENOG4105FFC UPF0187 protein AWN88_23960 ENOG4105D29 Helix-turn-helix type 11 domain protein AWN88_23970 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) AWN88_23975 ENOG4105CM2 brancheD-chain amino acid aminotransferase AWN88_23985 ENOG4105DUM transcriptional regulator, lysR family AWN88_24000 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AWN88_24010 ENOG4105D29 Helix-turn-helix type 11 domain protein AWN88_24015 ENOG4108NIW Leucine export protein LeuE AWN88_24020 ENOG4105TAV cytochrome C AWN88_24025 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AWN88_24085 ENOG4108IJ7 Glycine betaine AWN88_24090 ENOG4108HQS Glycine betaine AWN88_24110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_24120 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AWN88_24130 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AWN88_24140 ENOG4105NHS Transcriptional regulator, TraR DksA family AWN88_24145 ENOG4108UT2 hemolysin iii AWN88_24155 ENOG4105E0X reductase AWN88_24160 ENOG4105D65 subunit l AWN88_24165 ENOG4105HC0 Na H antiporter AWN88_24170 ENOG4108ZE9 Monovalent cation H antiporter subunit C AWN88_24175 ENOG4108JPZ Monovalent cation H antiporter subunit D AWN88_24180 ENOG4105SC1 monovalent cation H antiporter subunit E AWN88_24185 ENOG41080TA Multiple resistance and ph regulation protein f AWN88_24190 ENOG4105KJM monovalent cation h antiporter subunit g AWN88_24195 ENOG4108YXV Transcriptional regulator AWN88_24210 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AWN88_24215 ENOG4105WZR AWN88_24220 ENOG4105BZU Histidine kinase AWN88_24275 ENOG4108JQC penicillin-binding protein 1A AWN88_24280 ENOG4108ZZ3 UPF0260 protein AWN88_24335 ENOG4105CNG UPF0061 protein AWN88_24345 ENOG4105EW9 transcriptional regulator AsnC family AWN88_24470 ENOG4105XJC Two component transcriptional regulator (Winged helix family AWN88_24475 ENOG4105E0F Histidine kinase AWN88_24485 ENOG4106FI7 cytochrome c-type biogenesis protein AWN88_24490 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AWN88_24495 ENOG4105DA4 cytochrome c-type biogenesis protein AWN88_24500 ENOG4105KWW Biogenesis protein AWN88_24505 ENOG4105C0H protease AWN88_24510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AWN88_24515 ENOG4105JJR Histidine kinase AWN88_24525 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AWN88_24530 ENOG4105BZU Histidine kinase AWN88_24540 ENOG4105CD8 aminopeptidase N AWN88_24545 ENOG4108EHX EamA-like transporter family AWN88_24560 ENOG4105R8A Heat shock protein AWN88_24565 ENOG4105BZU Histidine kinase AWN88_24570 ENOG4105CHR reductase AWN88_24580 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AWN88_24590 ENOG4105CIS alcohol dehydrogenase AWN88_24595 ENOG4105KVH Transcriptional regulator AWN88_24600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AWN88_24605 ENOG4105CJW magnesium transporter AWN88_24610 ENOG4105F27 Major Facilitator AWN88_24620 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AWN88_24640 ENOG4105FYV Amp nucleosidase AWN88_24665 ENOG4105CIH Imidazole acetol-phosphate transaminase AWN88_24680 ENOG4105CNV Aldolase AWN88_24710 ENOG4107SC1 transglycosylase AWN88_24715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AWN88_24720 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AWN88_24735 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AWN88_24755 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AWN88_24760 ENOG4105C3F Signal peptidase i AWN88_24765 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AWN88_24770 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AWN88_24775 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AWN88_24780 ENOG41074H6 response regulator AWN88_24785 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) AWN88_24795 ENOG4105DMQ Methyltransferase AWN88_24805 ENOG4105EST Metal Dependent Phosphohydrolase AWN88_24830 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component AWN88_24835 ENOG4108MEK Metal-binding protein YodA AWN88_24840 ENOG4105D64 Mechanosensitive ion channel AWN88_24850 ENOG4108R7K Metal Dependent Phosphohydrolase AWN88_24875 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AWN88_24880 ENOG4105KK4 UPF0060 membrane protein AWN88_24890 ENOG4105BZU Histidine kinase AWN88_24895 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AWN88_24900 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme AWN88_24905 ENOG4108JJ7 ABC transporter AWN88_24915 ENOG4108URH decarboxylase AWN88_24925 ENOG4105FR1 rard protein AWN88_24945 ENOG4105WDY DNA (cytosine-5-)-methyltransferase AWN88_24950 ENOG4105C8N cysteinyl-tRNA synthetase AWN88_24955 ENOG4105PDP Short chain dehydrogenase AWN88_24960 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AWN88_24965 ENOG4105E96 Colicin v production protein AWN88_24985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AWN88_24990 ENOG4105E7U AraC family transcriptional regulator AWN88_24995 ENOG4108UMN azlc family AWN88_25005 ENOG4105CDU Replicative dna helicase AWN88_25025 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AWN88_25035 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AWN88_25040 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AWN88_25045 ENOG4105CPC Aldo Keto reductase AWN88_25050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AWN88_25060 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AWN88_25065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AWN88_25070 ENOG4105HHA aminodeoxychorismate lyase AWN88_25075 ENOG4105DSJ YicC domain protein AWN88_25080 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AWN88_25085 ENOG4105VGJ Virulence-associated protein AWN88_25090 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AWN88_25095 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AWN88_25100 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AWN88_25110 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AWN88_25125 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AWN88_25135 ENOG4105BZU Histidine kinase AWN88_25150 ENOG4105BZU Histidine kinase AWN88_25155 ENOG4105BZU Histidine kinase AWN88_25170 ENOG4105C5H ABC transporter AWN88_25175 ENOG4105BZU Histidine kinase AWN88_25185 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AWN88_25205 ENOG4108ZAF Molybdopterin AWN88_25220 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AWN88_25225 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AWN88_25230 ENOG4105JVC membrAne AWN88_25235 ENOG4108U78 Glutathione S-transferase AWN88_25250 ENOG4105D6S protein involved in catabolism of external DNA AWN88_25255 ENOG4107QY8 reductase AWN88_25260 ENOG4107VIJ nudix hydrolase AWN88_25275 ENOG4108V3E phosphoribosylglycinamide formyltransferase AWN88_25280 ENOG4105CXB phosphoribosylaminoimidazole synthetase AWN88_25285 ENOG4105C02 permease AWN88_25295 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AWN88_25300 ENOG4105C9X ppx gppa phosphatase AWN88_25325 ENOG4108Q35 Adenylate AWN88_25330 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AWN88_25335 ENOG4108ISG Major Facilitator AWN88_25340 ENOG4105C9M aspartyl-trna synthetase AWN88_25350 ENOG4105CT7 inner membrane cred family protein AWN88_25360 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AWN88_25370 ENOG41087RY SpoVT_AbrB AWN88_25375 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate AWN88_25385 ENOG4105D52 delta-aminolevulinic acid dehydratase AWN88_25410 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AWN88_25415 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AWN88_25420 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AWN88_25435 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AWN88_25440 ENOG4107XZX Involved in the transcription termination process (By similarity) AWN88_25445 ENOG4105DXI Major Facilitator superfamily AWN88_25450 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for AWN88_25470 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AWN88_25475 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AWN88_25480 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AWN88_25485 ENOG4105WJX transcriptional regulator MERR family