locus-tag	class	description
AWN88_00020	COG0601	transmembrane transport
AWN88_00025	COG0747	negative chemotaxis
AWN88_00030	COG2130	NADP-dependent
AWN88_00035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_00050	COG4977	sequence-specific DNA binding
AWN88_00055	COG3246	L-lysine catabolic process to acetate
AWN88_00060	COG0747	negative chemotaxis
AWN88_00065	COG0824	Thioesterase
AWN88_00065	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWN88_00075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_00105	COG0601	transmembrane transport
AWN88_00110	COG0747	negative chemotaxis
AWN88_00120	COG0583	DNA-binding transcription factor activity
AWN88_00130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWN88_00260	COG0563	adenylate kinase activity
AWN88_00265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWN88_00290	COG0183	Belongs to the thiolase family
AWN88_00305	COG0411	ABC transporter
AWN88_00310	COG0410	ABC transporter
AWN88_00315	COG0154	amidase activity
AWN88_00325	COG0473	3-isopropylmalate dehydrogenase activity
AWN88_00350	COG3833	ABC-type maltose transport systems, permease component
AWN88_00355	COG1177	transmembrane transport
AWN88_00360	COG3842	ATPase activity
AWN88_00385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWN88_00400	COG4644	lycopene metabolic process
AWN88_00405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWN88_00410	COG2084	Dehydrogenase
AWN88_00420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_00425	COG0444	Belongs to the ABC transporter superfamily
AWN88_00430	COG4608	Belongs to the ABC transporter superfamily
AWN88_00440	COG0747	negative chemotaxis
AWN88_00445	COG0601	transmembrane transport
AWN88_00450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_00465	COG1309	transcriptional regulator
AWN88_00475	COG4644	lycopene metabolic process
AWN88_00480	COG1609	Transcriptional regulator
AWN88_00485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_00490	COG0477	Major facilitator Superfamily
AWN88_00510	COG1960	acyl-CoA dehydrogenase activity
AWN88_00530	COG0411	ABC transporter
AWN88_00535	COG0410	ABC transporter
AWN88_00570	COG1609	Transcriptional regulator
AWN88_00580	COG2814	Major facilitator Superfamily
AWN88_00640	COG1475	DNA binding
AWN88_00665	COG5489	Protein of unknown function (DUF736)
AWN88_00670	COG1525	nuclease
AWN88_00675	COG3831	ATPase activity
AWN88_00740	COG4598	ABC transporter
AWN88_00745	COG4160	amino acid transport
AWN88_00750	COG0765	amino acid transport
AWN88_00760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AWN88_00765	COG1802	Transcriptional regulator
AWN88_00770	COG1522	sequence-specific DNA binding
AWN88_00775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AWN88_00800	COG3701	Conjugal transfer protein
AWN88_00805	COG3846	protein secretion by the type IV secretion system
AWN88_00815	COG5314	conjugation
AWN88_00820	COG3451	type IV secretory pathway VirB4
AWN88_00835	COG4962	Type ii secretion system protein e
AWN88_00845	COG1192	Involved in chromosome partitioning
AWN88_00850	COG1475	DNA binding
AWN88_00855	COG0640	Transcriptional regulator
AWN88_00880	COG0583	DNA-binding transcription factor activity
AWN88_00885	COG1073	alpha beta
AWN88_00890	COG1073	alpha beta
AWN88_00900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWN88_00925	COG1106	Psort location Cytoplasmic, score
AWN88_00955	COG1793	dna ligase
AWN88_00965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWN88_01010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWN88_01015	COG4959	Type IV secretory pathway protease TraF
AWN88_01020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWN88_01035	COG3505	Type IV secretory pathway VirD4
AWN88_01040	COG3831	ATPase activity
AWN88_01050	COG5489	Protein of unknown function (DUF736)
AWN88_01070	COG1475	DNA binding
AWN88_01105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AWN88_01155	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_01155	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AWN88_01165	COG2801	Transposase and inactivated derivatives
AWN88_01180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AWN88_01185	COG2086	electron transfer activity
AWN88_01195	COG0477	Major facilitator Superfamily
AWN88_01205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_01230	COG2963	transposase activity
AWN88_01235	COG3436	PFAM IS66 Orf2 family protein
AWN88_01240	COG4372	Transposase
AWN88_01255	COG0840	transmembrane signaling receptor activity
AWN88_01275	COG3344	reverse transcriptase
AWN88_01295	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_01300	COG1177	transmembrane transport
AWN88_01305	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_01310	COG3842	ATPase activity
AWN88_01315	COG1335	isochorismatase
AWN88_01320	COG2309	aminopeptidase activity
AWN88_01325	COG0596	Alpha beta hydrolase
AWN88_01330	COG3473	Maleate cis-trans isomerase
AWN88_01340	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_01375	COG2259	Doxx family
AWN88_01390	COG0583	DNA-binding transcription factor activity
AWN88_01395	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AWN88_01420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWN88_01475	COG0640	Transcriptional regulator
AWN88_01480	COG1475	DNA binding
AWN88_01485	COG1192	Involved in chromosome partitioning
AWN88_01490	COG4962	Type ii secretion system protein e
AWN88_01495	COG3838	Conjugal transfer protein Trbc
AWN88_01500	COG5268	conjugation
AWN88_01505	COG3451	type IV secretory pathway VirB4
AWN88_01510	COG5314	conjugation
AWN88_01520	COG3846	protein secretion by the type IV secretion system
AWN88_01525	COG3701	Conjugal transfer protein
AWN88_01530	COG3504	Conjugal transfer protein
AWN88_01540	COG2948	multi-organism process
AWN88_01620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_01625	COG2130	NADP-dependent
AWN88_01630	COG0747	negative chemotaxis
AWN88_01635	COG0601	transmembrane transport
AWN88_01645	COG4608	Belongs to the ABC transporter superfamily
AWN88_01650	COG1349	DNA-binding transcription factor activity
AWN88_01655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWN88_01695	COG4178	(ABC) transporter
AWN88_01725	COG0745	RESPONSE REGULATOR receiver
AWN88_01730	COG2205	protein histidine kinase activity
AWN88_01735	COG1764	response to oxidative stress
AWN88_01745	COG0596	Alpha beta hydrolase
AWN88_01765	COG0783	Belongs to the Dps family
AWN88_01770	COG0243	molybdopterin cofactor binding
AWN88_01780	COG4566	intracellular signal transduction
AWN88_01795	COG2140	Oxalate decarboxylase
AWN88_01825	COG5265	(ABC) transporter
AWN88_01830	COG3181	Tripartite tricarboxylate transporter family receptor
AWN88_01835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWN88_01890	COG3685	Protein conserved in bacteria
AWN88_01920	COG0297	glycogen (starch) synthase activity
AWN88_01930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWN88_01960	COG2010	Cytochrome c
AWN88_01985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWN88_02000	COG0243	molybdopterin cofactor binding
AWN88_02030	COG0753	catalase activity
AWN88_02045	COG0655	NAD(P)H dehydrogenase (quinone) activity
AWN88_02055	COG3237	CsbD-like
AWN88_02075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWN88_02085	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_02095	COG0405	Gamma-glutamyltransferase
AWN88_02105	COG0601	transmembrane transport
AWN88_02110	COG0747	negative chemotaxis
AWN88_02115	COG2186	Transcriptional regulator
AWN88_02125	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_02130	COG4172	Belongs to the ABC transporter superfamily
AWN88_02135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_02140	COG0601	transmembrane transport
AWN88_02145	COG0747	negative chemotaxis
AWN88_02160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_02175	COG3383	formate dehydrogenase (NAD+) activity
AWN88_02200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWN88_02205	COG1802	Transcriptional regulator
AWN88_02210	COG4608	Belongs to the ABC transporter superfamily
AWN88_02215	COG0444	Belongs to the ABC transporter superfamily
AWN88_02220	COG0402	S-adenosylhomocysteine deaminase activity
AWN88_02230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_02245	COG0402	S-adenosylhomocysteine deaminase activity
AWN88_02260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_02270	COG0765	amino acid transport
AWN88_02280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_02295	COG3938	Belongs to the proline racemase family
AWN88_02305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_02315	COG0765	amino acid transport
AWN88_02330	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWN88_02335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_02345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWN88_02350	COG0784	Response regulator, receiver
AWN88_02360	COG0842	Transport permease protein
AWN88_02365	COG0842	Transport permease protein
AWN88_02365	COG1129	ABC transporter
AWN88_02370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_02375	COG1486	melibiose metabolic process
AWN88_02380	COG4172	Belongs to the ABC transporter superfamily
AWN88_02385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_02390	COG0601	transmembrane transport
AWN88_02395	COG0747	negative chemotaxis
AWN88_02400	COG1486	melibiose metabolic process
AWN88_02425	COG1940	carbohydrate kinase activity
AWN88_02430	COG2182	Extracellular solute-binding protein
AWN88_02435	COG1175	transmembrane transport
AWN88_02440	COG0395	ABC-type sugar transport system, permease component
AWN88_02445	COG0165	Argininosuccinate lyase
AWN88_02450	COG3842	ATPase activity
AWN88_02455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_02460	COG3119	arylsulfatase activity
AWN88_02475	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_02495	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWN88_02515	COG1120	ATPase activity
AWN88_02520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_02525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_02535	COG4774	siderophore transport
AWN88_02540	COG2207	Transcriptional regulator
AWN88_02545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AWN88_02575	COG1392	Phosphate transport regulator
AWN88_02580	COG0306	phosphate transporter
AWN88_02585	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AWN88_02595	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AWN88_02605	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_02610	COG5001	Diguanylate cyclase
AWN88_02610	COG3300	MHYT domain
AWN88_02620	COG0747	negative chemotaxis
AWN88_02630	COG2186	Transcriptional regulator
AWN88_02635	COG0601	transmembrane transport
AWN88_02650	COG4608	Belongs to the ABC transporter superfamily
AWN88_02655	COG3842	ATPase activity
AWN88_02660	COG0395	ABC-type sugar transport system, permease component
AWN88_02675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWN88_02675	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWN88_02680	COG1609	Transcriptional regulator
AWN88_02695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AWN88_02700	COG1088	dTDP-glucose 4,6-dehydratase activity
AWN88_02705	COG1091	dTDP-4-dehydrorhamnose reductase activity
AWN88_02710	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AWN88_02725	COG3754	Rhamnan synthesis protein F
AWN88_02745	COG0300	oxidoreductase activity
AWN88_02760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWN88_02775	COG0318	PFAM AMP-dependent synthetase and ligase
AWN88_02790	COG3958	Transketolase
AWN88_02795	COG3959	Transketolase, thiamine diphosphate binding domain
AWN88_02815	COG1132	(ABC) transporter
AWN88_02825	COG0583	DNA-binding transcription factor activity
AWN88_02830	COG0667	Aldo Keto reductase
AWN88_02835	COG0385	Bile acid
AWN88_02875	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_02880	COG0584	glycerophosphoryl diester phosphodiesterase
AWN88_02890	COG4149	molybdate abc transporter
AWN88_02895	COG3842	ATPase activity
AWN88_02905	COG1940	carbohydrate kinase activity
AWN88_02920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AWN88_02930	COG3842	ATPase activity
AWN88_02935	COG1175	transmembrane transport
AWN88_02940	COG0395	ABC-type sugar transport system, permease component
AWN88_02950	COG0747	negative chemotaxis
AWN88_02955	COG0601	transmembrane transport
AWN88_02960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_02970	COG4608	Belongs to the ABC transporter superfamily
AWN88_02975	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AWN88_02990	COG0346	lactoylglutathione lyase activity
AWN88_03000	COG0129	dihydroxy-acid dehydratase activity
AWN88_03005	COG1879	ABC-type sugar transport system periplasmic component
AWN88_03010	COG1129	ABC transporter
AWN88_03015	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_03020	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_03025	COG2186	Transcriptional regulator
AWN88_03055	COG0673	inositol 2-dehydrogenase activity
AWN88_03065	COG3842	ATPase activity
AWN88_03070	COG0395	ABC-type sugar transport system, permease component
AWN88_03075	COG1175	transmembrane transport
AWN88_03080	COG1653	transport
AWN88_03090	COG0673	inositol 2-dehydrogenase activity
AWN88_03105	COG5001	Diguanylate cyclase
AWN88_03110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_03120	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AWN88_03125	COG2894	cell division
AWN88_03130	COG0850	regulation of cytokinetic process
AWN88_03140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWN88_03145	COG2186	Transcriptional regulator
AWN88_03150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_03160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWN88_03165	COG1063	alcohol dehydrogenase
AWN88_03170	COG1312	Catalyzes the dehydration of D-mannonate
AWN88_03185	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_03190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWN88_03195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_03205	COG0640	Transcriptional regulator
AWN88_03210	COG0625	glutathione transferase activity
AWN88_03220	COG1921	L-seryl-tRNASec selenium transferase activity
AWN88_03235	COG3964	amidohydrolase
AWN88_03245	COG0601	transmembrane transport
AWN88_03250	COG0747	negative chemotaxis
AWN88_03255	COG0438	transferase activity, transferring glycosyl groups
AWN88_03290	COG4989	oxidoreductase activity
AWN88_03305	COG3842	ATPase activity
AWN88_03310	COG1653	transport
AWN88_03315	COG1175	transmembrane transport
AWN88_03320	COG0395	ABC-type sugar transport system, permease component
AWN88_03325	COG1501	Belongs to the glycosyl hydrolase 31 family
AWN88_03330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_03335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_03340	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AWN88_03345	COG0352	thiamine-phosphate diphosphorylase activity
AWN88_03350	COG0351	phosphomethylpyrimidine kinase
AWN88_03355	COG1522	sequence-specific DNA binding
AWN88_03360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AWN88_03365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_03380	COG2204	response regulator
AWN88_03385	COG4191	Histidine kinase
AWN88_03390	COG1301	dicarboxylic acid transport
AWN88_03400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AWN88_03405	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_03435	COG1215	transferase activity, transferring glycosyl groups
AWN88_03445	COG2942	2-epimerase
AWN88_03480	COG2197	response regulator
AWN88_03510	COG3307	-O-antigen
AWN88_03515	COG1596	polysaccharide export
AWN88_03520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AWN88_03535	COG1410	methionine synthase
AWN88_03535	COG0646	methionine synthase
AWN88_03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_03575	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_03585	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_03595	COG2094	Belongs to the DNA glycosylase MPG family
AWN88_03605	COG1609	Transcriptional regulator
AWN88_03610	COG1653	transport
AWN88_03625	COG3842	ATPase activity
AWN88_03635	COG0673	inositol 2-dehydrogenase activity
AWN88_03640	COG0602	queuosine metabolic process
AWN88_03645	COG0720	synthase
AWN88_03650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AWN88_03655	COG0673	inositol 2-dehydrogenase activity
AWN88_03670	COG0395	ABC-type sugar transport system, permease component
AWN88_03705	COG0583	DNA-binding transcription factor activity
AWN88_03710	COG0281	malic enzyme
AWN88_03710	COG0280	phosphate acetyltransferase
AWN88_03725	COG0765	amino acid transport
AWN88_03735	COG2079	MmgE PrpD family protein
AWN88_03750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_03775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AWN88_03780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AWN88_03785	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_03790	COG1129	ABC transporter
AWN88_03800	COG1473	amidohydrolase
AWN88_03815	COG4172	Belongs to the ABC transporter superfamily
AWN88_03825	COG0601	transmembrane transport
AWN88_03835	COG1446	asparaginase
AWN88_03850	COG0747	negative chemotaxis
AWN88_03875	COG0601	transmembrane transport
AWN88_03880	COG2197	response regulator
AWN88_03885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWN88_03890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWN88_03905	COG0395	ABC-type sugar transport system, permease component
AWN88_03910	COG1175	transmembrane transport
AWN88_03920	COG0673	inositol 2-dehydrogenase activity
AWN88_03925	COG0673	inositol 2-dehydrogenase activity
AWN88_03945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_03950	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AWN88_03960	COG1120	ATPase activity
AWN88_03965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_03980	COG2226	methyltransferase
AWN88_03990	COG1120	ATPase activity
AWN88_03995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_04010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWN88_04015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_04025	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_04030	COG0473	3-isopropylmalate dehydrogenase activity
AWN88_04035	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_04065	COG3842	ATPase activity
AWN88_04070	COG1178	ABC-type Fe3 transport system permease component
AWN88_04125	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_04135	COG1879	ABC-type sugar transport system periplasmic component
AWN88_04145	COG1063	alcohol dehydrogenase
AWN88_04150	COG3842	ATPase activity
AWN88_04160	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_04165	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_04180	COG1309	transcriptional regulator
AWN88_04190	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_04195	COG1414	Transcriptional regulator
AWN88_04200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWN88_04205	COG3842	ATPase activity
AWN88_04210	COG0395	ABC-type sugar transport system, permease component
AWN88_04215	COG1175	transmembrane transport
AWN88_04225	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_04230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_04235	COG3734	2-keto-3-deoxy-galactonokinase
AWN88_04245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AWN88_04250	COG0583	DNA-binding transcription factor activity
AWN88_04255	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AWN88_04270	COG0028	Belongs to the TPP enzyme family
AWN88_04275	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_04290	COG1125	glycine betaine transport
AWN88_04290	COG0517	IMP dehydrogenase activity
AWN88_04315	COG2986	histidine ammonia-lyase
AWN88_04345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AWN88_04390	COG4221	oxidoreductase activity
AWN88_04445	COG0395	ABC-type sugar transport system, permease component
AWN88_04450	COG1063	alcohol dehydrogenase
AWN88_04455	COG3842	ATPase activity
AWN88_04460	COG0587	DNA-directed DNA polymerase activity
AWN88_04505	COG0071	Belongs to the small heat shock protein (HSP20) family
AWN88_04530	COG3005	denitrification pathway
AWN88_04540	COG0243	molybdopterin cofactor binding
AWN88_04555	COG4459	periplasmic nitrate reductase
AWN88_04565	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AWN88_04600	COG3189	MarR family transcriptional regulator
AWN88_04605	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AWN88_04610	COG0163	prenyltransferase activity
AWN88_04635	COG3256	nitric oxide reductase
AWN88_04640	COG0714	Associated with various cellular activities
AWN88_04680	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AWN88_04715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWN88_04730	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_04735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWN88_04740	COG2204	response regulator
AWN88_04745	COG4191	Histidine kinase
AWN88_04750	COG0668	transmembrane transport
AWN88_04775	COG4566	intracellular signal transduction
AWN88_04780	COG1959	2 iron, 2 sulfur cluster binding
AWN88_04790	COG0668	transmembrane transport
AWN88_04830	COG0640	Transcriptional regulator
AWN88_04840	COG0431	NADPH-dependent FMN reductase
AWN88_04850	COG0798	PFAM Bile acid sodium symporter
AWN88_04900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWN88_04905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWN88_04980	COG1196	nuclear chromosome segregation
AWN88_04980	COG0741	lytic transglycosylase activity
AWN88_04980	COG0739	heme binding
AWN88_04985	COG0542	response to heat
AWN88_04995	COG2890	protein-(glutamine-N5) methyltransferase activity
AWN88_05000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AWN88_05010	COG0527	aspartate kinase activity
AWN88_05025	COG0019	diaminopimelate decarboxylase activity
AWN88_05040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AWN88_05060	COG0784	Response regulator, receiver
AWN88_05075	COG1522	sequence-specific DNA binding
AWN88_05085	COG1116	anion transmembrane transporter activity
AWN88_05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_05095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_05100	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_05105	COG0583	DNA-binding transcription factor activity
AWN88_05115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AWN88_05120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWN88_05125	COG0189	ligase activity
AWN88_05150	COG0693	protein deglycase activity
AWN88_05170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWN88_05175	COG1285	pathogenesis
AWN88_05180	COG3685	Protein conserved in bacteria
AWN88_05185	COG4993	Dehydrogenase
AWN88_05195	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_05200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWN88_05220	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWN88_05225	COG0410	ABC transporter
AWN88_05245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_05260	COG0246	Mannitol dehydrogenase
AWN88_05265	COG4608	Belongs to the ABC transporter superfamily
AWN88_05270	COG0444	Belongs to the ABC transporter superfamily
AWN88_05275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_05280	COG0601	transmembrane transport
AWN88_05285	COG0747	negative chemotaxis
AWN88_05295	COG4221	oxidoreductase activity
AWN88_05325	COG0539	negative regulation of cytoplasmic translation
AWN88_05330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AWN88_05360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AWN88_05365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AWN88_05395	COG1294	oxidase, subunit
AWN88_05405	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AWN88_05410	COG4988	ABC transporter
AWN88_05420	COG1063	alcohol dehydrogenase
AWN88_05425	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_05430	COG2084	Dehydrogenase
AWN88_05440	COG1522	sequence-specific DNA binding
AWN88_05445	COG1794	racemase activity, acting on amino acids and derivatives
AWN88_05455	COG0058	SHG alpha-glucan phosphorylase activity
AWN88_05460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AWN88_05465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AWN88_05470	COG0297	glycogen (starch) synthase activity
AWN88_05475	COG0033	Phosphoglucomutase
AWN88_05500	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWN88_05500	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWN88_05515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_05520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWN88_05540	COG1215	transferase activity, transferring glycosyl groups
AWN88_05545	COG2327	Polysaccharide pyruvyl transferase
AWN88_05550	COG0463	Glycosyl transferase, family 2
AWN88_05555	COG2244	polysaccharide biosynthetic process
AWN88_05560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWN88_05565	COG2273	Hydrolase Family 16
AWN88_05570	COG0438	transferase activity, transferring glycosyl groups
AWN88_05575	COG1215	transferase activity, transferring glycosyl groups
AWN88_05580	COG1215	transferase activity, transferring glycosyl groups
AWN88_05585	COG1215	transferase activity, transferring glycosyl groups
AWN88_05590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWN88_05595	COG0489	protein tyrosine kinase activity
AWN88_05595	COG3206	protein involved in exopolysaccharide biosynthesis
AWN88_05605	COG4191	Histidine kinase
AWN88_05605	COG0784	Response regulator, receiver
AWN88_05615	COG4176	ABC-type proline glycine betaine transport system permease component
AWN88_05620	COG4175	Glycine betaine
AWN88_05620	COG3448	diguanylate cyclase activity
AWN88_05640	COG0500	methyltransferase
AWN88_05650	COG2133	pyrroloquinoline quinone binding
AWN88_05660	COG2197	response regulator
AWN88_05665	COG4585	Histidine kinase
AWN88_05670	COG1879	ABC-type sugar transport system periplasmic component
AWN88_05675	COG1129	ABC transporter
AWN88_05680	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_05690	COG3386	PFAM SMP-30 Gluconolaconase
AWN88_05695	COG2137	regulation of response to DNA damage stimulus
AWN88_05710	COG1120	ATPase activity
AWN88_05725	COG4774	siderophore transport
AWN88_05730	COG0583	DNA-binding transcription factor activity
AWN88_05740	COG2194	sulfuric ester hydrolase activity
AWN88_05745	COG0745	RESPONSE REGULATOR receiver
AWN88_05750	COG0642	Histidine kinase
AWN88_05755	COG0477	Major facilitator Superfamily
AWN88_05775	COG0673	inositol 2-dehydrogenase activity
AWN88_05780	COG0697	spore germination
AWN88_05820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWN88_05825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AWN88_05830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AWN88_05840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AWN88_05880	COG0671	phosphoesterase, PA-phosphatase related
AWN88_05885	COG0745	RESPONSE REGULATOR receiver
AWN88_05890	COG3850	Histidine kinase
AWN88_05890	COG5002	protein histidine kinase activity
AWN88_05895	COG0477	Major facilitator Superfamily
AWN88_05900	COG0583	DNA-binding transcription factor activity
AWN88_05920	COG1574	metal-dependent hydrolase with the TIM-barrel fold
AWN88_05935	COG0346	lactoylglutathione lyase activity
AWN88_05940	COG0583	DNA-binding transcription factor activity
AWN88_05955	COG1522	sequence-specific DNA binding
AWN88_05960	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_05965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AWN88_05970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWN88_05975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWN88_05980	COG2423	ornithine cyclodeaminase activity
AWN88_05985	COG0006	proline dipeptidase activity
AWN88_05990	COG3608	succinylglutamate desuccinylase aspartoacylase
AWN88_05995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_06000	COG0765	amino acid transport
AWN88_06005	COG0765	amino acid transport
AWN88_06010	COG1126	abc transporter atp-binding protein
AWN88_06015	COG1609	Transcriptional regulator
AWN88_06020	COG1082	Xylose isomerase domain protein TIM barrel
AWN88_06025	COG0673	inositol 2-dehydrogenase activity
AWN88_06030	COG1082	Xylose isomerase domain protein TIM barrel
AWN88_06050	COG1473	amidohydrolase
AWN88_06065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_06070	COG0601	transmembrane transport
AWN88_06075	COG0747	negative chemotaxis
AWN88_06115	COG4529	Protein conserved in bacteria
AWN88_06120	COG0598	Magnesium transport protein CorA
AWN88_06125	COG2354	Protein conserved in bacteria
AWN88_06135	COG1215	transferase activity, transferring glycosyl groups
AWN88_06145	COG3300	MHYT domain
AWN88_06145	COG5001	Diguanylate cyclase
AWN88_06155	COG4166	transmembrane transport
AWN88_06160	COG0601	transmembrane transport
AWN88_06165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_06170	COG4172	Belongs to the ABC transporter superfamily
AWN88_06185	COG3586	endonuclease activity
AWN88_06200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AWN88_06205	COG1451	nucleotide metabolic process
AWN88_06225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AWN88_06270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_06275	COG4172	Belongs to the ABC transporter superfamily
AWN88_06285	COG0601	transmembrane transport
AWN88_06290	COG0747	negative chemotaxis
AWN88_06300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AWN88_06305	COG1454	alcohol dehydrogenase
AWN88_06310	COG2186	Transcriptional regulator
AWN88_06325	COG1607	acyl-coa hydrolase
AWN88_06345	COG2307	Protein conserved in bacteria
AWN88_06345	COG2308	Evidence 4 Homologs of previously reported genes of
AWN88_06360	COG0488	(ABC) transporter
AWN88_06365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_06370	COG1304	FMN binding
AWN88_06380	COG1846	Transcriptional regulator
AWN88_06385	COG1070	Carbohydrate kinase
AWN88_06390	COG1830	Aldolase
AWN88_06395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWN88_06400	COG0667	Aldo Keto reductase
AWN88_06410	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_06415	COG1129	ABC transporter
AWN88_06450	COG0071	Belongs to the small heat shock protein (HSP20) family
AWN88_06465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWN88_06480	COG0395	ABC-type sugar transport system, permease component
AWN88_06490	COG3842	ATPase activity
AWN88_06510	COG1648	precorrin-2 dehydrogenase activity
AWN88_06510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWN88_06515	COG0243	molybdopterin cofactor binding
AWN88_06525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AWN88_06530	COG1116	anion transmembrane transporter activity
AWN88_06535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_06540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_06545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_06550	COG3707	response regulator
AWN88_06555	COG1802	Transcriptional regulator
AWN88_06560	COG1914	H( )-stimulated, divalent metal cation uptake system
AWN88_06565	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AWN88_06570	COG4336	lyase activity
AWN88_06575	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AWN88_06580	COG4770	biotin carboxylase activity
AWN88_06585	COG0366	Alpha amylase catalytic
AWN88_06590	COG0789	Transcriptional regulator
AWN88_06595	COG4771	TonB-dependent receptor
AWN88_06600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWN88_06620	COG1414	Transcriptional regulator
AWN88_06625	COG1475	DNA binding
AWN88_06630	COG1192	Involved in chromosome partitioning
AWN88_06665	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AWN88_06675	COG2986	histidine ammonia-lyase
AWN88_06680	COG1228	amidohydrolase
AWN88_06685	COG0402	S-adenosylhomocysteine deaminase activity
AWN88_06730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_06760	COG2207	Transcriptional regulator
AWN88_06765	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_06770	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_06810	COG1129	ABC transporter
AWN88_06815	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_06820	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_06825	COG1082	Xylose isomerase domain protein TIM barrel
AWN88_06830	COG0572	uridine kinase
AWN88_06835	COG1082	Xylose isomerase domain protein TIM barrel
AWN88_06840	COG2080	2 iron, 2 sulfur cluster binding
AWN88_06845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AWN88_06850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWN88_06855	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_06865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_06875	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_06885	COG1653	transport
AWN88_06890	COG0395	ABC-type sugar transport system, permease component
AWN88_06895	COG4209	transmembrane transport
AWN88_06900	COG3842	ATPase activity
AWN88_06905	COG1802	Transcriptional regulator
AWN88_06910	COG0583	DNA-binding transcription factor activity
AWN88_06915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_06920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AWN88_06940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_06945	COG0583	DNA-binding transcription factor activity
AWN88_06960	COG1846	Transcriptional regulator
AWN88_06980	COG3706	GGDEF domain
AWN88_06985	COG0840	transmembrane signaling receptor activity
AWN88_06995	COG0583	DNA-binding transcription factor activity
AWN88_07010	COG1595	DNA-templated transcription, initiation
AWN88_07030	COG2197	response regulator
AWN88_07050	COG2202	Pas domain
AWN88_07050	COG3920	Histidine kinase
AWN88_07055	COG0784	Response regulator, receiver
AWN88_07060	COG0784	Response regulator, receiver
AWN88_07060	COG4191	Histidine kinase
AWN88_07070	COG0747	negative chemotaxis
AWN88_07075	COG0601	transmembrane transport
AWN88_07080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_07090	COG4608	Belongs to the ABC transporter superfamily
AWN88_07115	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AWN88_07120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AWN88_07140	COG1566	PFAM secretion protein HlyD family protein
AWN88_07160	COG0583	DNA-binding transcription factor activity
AWN88_07185	COG0583	DNA-binding transcription factor activity
AWN88_07195	COG2207	Transcriptional regulator
AWN88_07215	COG1566	PFAM secretion protein HlyD family protein
AWN88_07230	COG1120	ATPase activity
AWN88_07240	COG4774	siderophore transport
AWN88_07260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWN88_07280	COG1063	alcohol dehydrogenase
AWN88_07285	COG3284	Transcriptional regulator
AWN88_07290	COG3706	GGDEF domain
AWN88_07300	COG0583	DNA-binding transcription factor activity
AWN88_07310	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_07315	COG1177	transmembrane transport
AWN88_07320	COG3842	ATPase activity
AWN88_07325	COG2072	flavoprotein involved in K transport
AWN88_07345	COG0534	Mate efflux family protein
AWN88_07375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWN88_07390	COG1349	DNA-binding transcription factor activity
AWN88_07395	COG1535	isochorismatase
AWN88_07395	COG3433	isochorismatase activity
AWN88_07400	COG1177	transmembrane transport
AWN88_07405	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_07410	COG3842	ATPase activity
AWN88_07420	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_07435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWN88_07445	COG2985	domain, Protein
AWN88_07450	COG2972	Histidine kinase
AWN88_07450	COG0840	transmembrane signaling receptor activity
AWN88_07455	COG0667	Aldo Keto reductase
AWN88_07465	COG0583	DNA-binding transcription factor activity
AWN88_07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWN88_07485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWN88_07490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AWN88_07495	COG2080	2 iron, 2 sulfur cluster binding
AWN88_07500	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AWN88_07505	COG1309	transcriptional regulator
AWN88_07510	COG0405	Gamma-glutamyltransferase
AWN88_07530	COG0583	DNA-binding transcription factor activity
AWN88_07540	COG1335	isochorismatase
AWN88_07545	COG3920	Histidine kinase
AWN88_07580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AWN88_07605	COG4251	negative regulation of phosphorylation
AWN88_07610	COG0784	Response regulator, receiver
AWN88_07615	COG3920	Histidine kinase
AWN88_07615	COG2202	Pas domain
AWN88_07620	COG0784	Response regulator, receiver
AWN88_07625	COG2205	protein histidine kinase activity
AWN88_07625	COG0784	Response regulator, receiver
AWN88_07630	COG0745	RESPONSE REGULATOR receiver
AWN88_07645	COG1215	transferase activity, transferring glycosyl groups
AWN88_07655	COG0395	ABC-type sugar transport system, permease component
AWN88_07675	COG1522	sequence-specific DNA binding
AWN88_07690	COG0583	DNA-binding transcription factor activity
AWN88_07695	COG2828	Protein conserved in bacteria
AWN88_07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_07715	COG3842	ATPase activity
AWN88_07720	COG0395	ABC-type sugar transport system, permease component
AWN88_07725	COG1175	transmembrane transport
AWN88_07740	COG0673	inositol 2-dehydrogenase activity
AWN88_07745	COG1609	Transcriptional regulator
AWN88_07750	COG1309	transcriptional regulator
AWN88_07755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_07775	COG2186	Transcriptional regulator
AWN88_07780	COG1027	Aspartate ammonia-lyase
AWN88_07790	COG0252	asparaginase activity
AWN88_07800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AWN88_07805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AWN88_07810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AWN88_07815	COG2205	protein histidine kinase activity
AWN88_07830	COG0070	glutamate synthase
AWN88_07830	COG0069	glutamate synthase activity
AWN88_07830	COG0067	glutamate synthase
AWN88_07840	COG2205	protein histidine kinase activity
AWN88_07855	COG2951	lytic endotransglycosylase activity
AWN88_07860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AWN88_07885	COG0330	HflC and HflK could
AWN88_07890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AWN88_07895	COG0737	Belongs to the 5'-nucleotidase family
AWN88_07905	COG5310	Homospermidine synthase
AWN88_07910	COG3706	GGDEF domain
AWN88_07910	COG0745	RESPONSE REGULATOR receiver
AWN88_07915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWN88_07920	COG1164	Oligoendopeptidase f
AWN88_07925	COG2204	response regulator
AWN88_07930	COG3108	Peptidase M15
AWN88_07935	COG0469	pyruvate kinase activity
AWN88_07955	COG3750	Belongs to the UPF0335 family
AWN88_07960	COG0457	Tetratricopeptide repeat
AWN88_07965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AWN88_07970	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AWN88_07975	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AWN88_08000	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_08020	COG1132	(ABC) transporter
AWN88_08025	COG0254	rRNA binding
AWN88_08045	COG3588	fructose-bisphosphate aldolase
AWN88_08050	COG0126	phosphoglycerate kinase activity
AWN88_08085	COG1253	flavin adenine dinucleotide binding
AWN88_08090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AWN88_08095	COG1692	metallophosphoesterase
AWN88_08110	COG0217	transcriptional regulatory protein
AWN88_08115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_08120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AWN88_08125	COG0632	four-way junction helicase activity
AWN88_08130	COG2255	four-way junction helicase activity
AWN88_08145	COG0494	nUDIX hydrolase
AWN88_08155	COG0824	Thioesterase
AWN88_08175	COG0823	Involved in the tonB-independent uptake of proteins
AWN88_08180	COG2885	chlorophyll binding
AWN88_08190	COG0037	tRNA processing
AWN88_08195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWN88_08200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWN88_08215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_08235	COG0482	sulfurtransferase activity
AWN88_08270	COG2835	tetraacyldisaccharide 4'-kinase activity
AWN88_08275	COG2373	Large extracellular alpha-helical protein
AWN88_08280	COG4953	penicillin-binding protein 1C
AWN88_08295	COG1473	amidohydrolase
AWN88_08300	COG1686	Belongs to the peptidase S11 family
AWN88_08305	COG0523	cobalamin synthesis protein
AWN88_08310	COG0425	Belongs to the sulfur carrier protein TusA family
AWN88_08315	COG3034	peptidoglycan biosynthetic process
AWN88_08320	COG0825	malonyl-CoA metabolic process
AWN88_08325	COG4974	Belongs to the 'phage' integrase family
AWN88_08335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AWN88_08340	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AWN88_08375	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AWN88_08380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AWN88_08395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWN88_08400	COG2226	methyltransferase
AWN88_08405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWN88_08410	COG0287	Prephenate dehydrogenase
AWN88_08420	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AWN88_08440	COG2884	Cell division ATP-binding protein ftsE
AWN88_08475	COG0165	Argininosuccinate lyase
AWN88_08480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AWN88_08485	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWN88_08495	COG2086	electron transfer activity
AWN88_08505	COG2096	Adenosyltransferase
AWN88_08515	COG0300	oxidoreductase activity
AWN88_08525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWN88_08535	COG3800	Transcriptional regulator
AWN88_08535	COG1396	sequence-specific DNA binding
AWN88_08540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWN88_08545	COG0625	glutathione transferase activity
AWN88_08585	COG4213	ABC transporter substrate-binding protein
AWN88_08590	COG4214	carbohydrate transport
AWN88_08595	COG1129	ABC transporter
AWN88_08605	COG1396	sequence-specific DNA binding
AWN88_08650	COG2273	Hydrolase Family 16
AWN88_08650	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AWN88_08670	COG0438	transferase activity, transferring glycosyl groups
AWN88_08675	COG0438	transferase activity, transferring glycosyl groups
AWN88_08680	COG0297	glycogen (starch) synthase activity
AWN88_08695	COG3206	protein involved in exopolysaccharide biosynthesis
AWN88_08695	COG0489	protein tyrosine kinase activity
AWN88_08705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWN88_08725	COG2244	polysaccharide biosynthetic process
AWN88_08730	COG1215	transferase activity, transferring glycosyl groups
AWN88_08765	COG1733	regulation of RNA biosynthetic process
AWN88_08795	COG0697	spore germination
AWN88_08800	COG0653	protein targeting
AWN88_08805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AWN88_08810	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AWN88_08815	COG0456	acetyltransferase
AWN88_08820	COG0494	nUDIX hydrolase
AWN88_08830	COG2226	methyltransferase
AWN88_08835	COG1040	competence protein
AWN88_08845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWN88_08855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AWN88_08870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AWN88_08885	COG4208	sulfate ABC transporter
AWN88_08890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWN88_08895	COG4335	DNA alkylation repair
AWN88_08910	COG5001	Diguanylate cyclase
AWN88_08915	COG2264	protein methyltransferase activity
AWN88_08930	COG3254	rhamnose metabolic process
AWN88_08940	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_08945	COG1129	ABC transporter
AWN88_08955	COG1349	DNA-binding transcription factor activity
AWN88_08960	COG3347	Dehydrogenase
AWN88_08960	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_08965	COG4952	isomerase
AWN88_08970	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AWN88_08975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AWN88_08980	COG1024	Enoyl-CoA hydratase
AWN88_08995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AWN88_09000	COG1960	acyl-CoA dehydrogenase activity
AWN88_09010	COG1960	acyl-CoA dehydrogenase activity
AWN88_09020	COG0022	dehydrogenase e1 component
AWN88_09030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AWN88_09035	COG2391	methyltransferase activity
AWN88_09045	COG0640	Transcriptional regulator
AWN88_09050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWN88_09050	COG3453	Protein conserved in bacteria
AWN88_09060	COG0300	oxidoreductase activity
AWN88_09075	COG2186	Transcriptional regulator
AWN88_09085	COG0601	transmembrane transport
AWN88_09095	COG0444	Belongs to the ABC transporter superfamily
AWN88_09100	COG4608	Belongs to the ABC transporter superfamily
AWN88_09120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09150	COG1473	amidohydrolase
AWN88_09155	COG0747	negative chemotaxis
AWN88_09165	COG4166	transmembrane transport
AWN88_09175	COG0583	DNA-binding transcription factor activity
AWN88_09185	COG0667	Aldo Keto reductase
AWN88_09220	COG1960	acyl-CoA dehydrogenase activity
AWN88_09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWN88_09255	COG1959	2 iron, 2 sulfur cluster binding
AWN88_09260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09270	COG1473	amidohydrolase
AWN88_09285	COG1126	abc transporter atp-binding protein
AWN88_09300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_09305	COG1522	sequence-specific DNA binding
AWN88_09315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_09350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_09365	COG3237	CsbD-like
AWN88_09370	COG2197	response regulator
AWN88_09380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWN88_09395	COG3842	ATPase activity
AWN88_09400	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_09405	COG1177	transmembrane transport
AWN88_09410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AWN88_09420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AWN88_09445	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWN88_09445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWN88_09465	COG1879	ABC-type sugar transport system periplasmic component
AWN88_09470	COG1129	ABC transporter
AWN88_09475	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_09480	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_09485	COG1609	Transcriptional regulator
AWN88_09495	COG0673	inositol 2-dehydrogenase activity
AWN88_09520	COG0583	DNA-binding transcription factor activity
AWN88_09535	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
AWN88_09540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_09565	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_09570	COG0431	NADPH-dependent FMN reductase
AWN88_09580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_09590	COG4172	Belongs to the ABC transporter superfamily
AWN88_09595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_09605	COG0747	negative chemotaxis
AWN88_09620	COG0277	FAD linked oxidase domain protein
AWN88_09640	COG0778	Nitroreductase
AWN88_09665	COG0488	(ABC) transporter
AWN88_09670	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_09685	COG2977	Belongs to the P-Pant transferase superfamily
AWN88_09690	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_09695	COG1535	isochorismatase
AWN88_09695	COG3433	isochorismatase activity
AWN88_09700	COG1021	2,3-dihydroxybenzoate-AMP ligase
AWN88_09705	COG1169	isochorismate synthase
AWN88_09715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWN88_09715	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AWN88_09720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AWN88_09730	COG2375	cellular response to nickel ion
AWN88_09735	COG4607	ABC-type enterochelin transport system periplasmic component
AWN88_09740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_09745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_09765	COG4774	siderophore transport
AWN88_09765	COG1629	transport
AWN88_09770	COG1960	acyl-CoA dehydrogenase activity
AWN88_09775	COG0583	DNA-binding transcription factor activity
AWN88_09780	COG1609	Transcriptional regulator
AWN88_09790	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_09800	COG3842	ATPase activity
AWN88_09810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWN88_09820	COG1473	amidohydrolase
AWN88_09825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWN88_09835	COG0747	negative chemotaxis
AWN88_09840	COG0601	transmembrane transport
AWN88_09850	COG0444	Belongs to the ABC transporter superfamily
AWN88_09855	COG4608	Belongs to the ABC transporter superfamily
AWN88_09860	COG0583	DNA-binding transcription factor activity
AWN88_09865	COG0747	negative chemotaxis
AWN88_09875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_09885	COG0693	protein deglycase activity
AWN88_09895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_09900	COG0601	transmembrane transport
AWN88_09910	COG1473	amidohydrolase
AWN88_09915	COG4172	Belongs to the ABC transporter superfamily
AWN88_09920	COG2390	Transcriptional regulator
AWN88_09930	COG1175	transmembrane transport
AWN88_09935	COG0395	ABC-type sugar transport system, permease component
AWN88_09950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWN88_09980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWN88_09990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AWN88_09995	COG1414	Transcriptional regulator
AWN88_10000	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_10005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWN88_10010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWN88_10015	COG1121	(ABC) transporter
AWN88_10020	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWN88_10030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AWN88_10035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AWN88_10040	COG0471	metal ion transport
AWN88_10040	COG3273	potassium ion transport
AWN88_10050	COG1253	flavin adenine dinucleotide binding
AWN88_10055	COG1309	transcriptional regulator
AWN88_10070	COG1609	Transcriptional regulator
AWN88_10075	COG1070	Carbohydrate kinase
AWN88_10080	COG2115	Belongs to the xylose isomerase family
AWN88_10090	COG0778	Nitroreductase
AWN88_10095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AWN88_10100	COG2011	ABC-type metal ion transport system permease component
AWN88_10110	COG5001	Diguanylate cyclase
AWN88_10110	COG3300	MHYT domain
AWN88_10130	COG0800	Aldolase
AWN88_10150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AWN88_10190	COG0523	cobalamin synthesis protein
AWN88_10200	COG1846	Transcriptional regulator
AWN88_10205	COG1609	Transcriptional regulator
AWN88_10210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AWN88_10220	COG3718	enzyme involved in inositol metabolism
AWN88_10230	COG3962	Belongs to the TPP enzyme family
AWN88_10235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_10265	COG0683	leucine binding
AWN88_10280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_10290	COG0747	negative chemotaxis
AWN88_10315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AWN88_10320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWN88_10325	COG1126	abc transporter atp-binding protein
AWN88_10330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_10335	COG0765	amino acid transport
AWN88_10340	COG0765	amino acid transport
AWN88_10345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWN88_10350	COG3485	protocatechuate 3,4-dioxygenase
AWN88_10355	COG3485	protocatechuate 3,4-dioxygenase
AWN88_10360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AWN88_10370	COG0583	DNA-binding transcription factor activity
AWN88_10385	COG1414	Transcriptional regulator
AWN88_10395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AWN88_10400	COG0183	Belongs to the thiolase family
AWN88_10405	COG1609	Transcriptional regulator
AWN88_10420	COG1082	Xylose isomerase domain protein TIM barrel
AWN88_10425	COG0673	inositol 2-dehydrogenase activity
AWN88_10435	COG1609	Transcriptional regulator
AWN88_10440	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWN88_10445	COG5001	Diguanylate cyclase
AWN88_10445	COG3300	MHYT domain
AWN88_10455	COG3257	ureidoglycine aminohydrolase activity
AWN88_10465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_10470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWN88_10480	COG1129	ABC transporter
AWN88_10485	COG1172	Belongs to the binding-protein-dependent transport system permease family
AWN88_10490	COG1879	ABC-type sugar transport system periplasmic component
AWN88_10495	COG0583	DNA-binding transcription factor activity
AWN88_10525	COG3047	cAMP biosynthetic process
AWN88_10540	COG3842	ATPase activity
AWN88_10545	COG0395	ABC-type sugar transport system, permease component
AWN88_10550	COG1175	transmembrane transport
AWN88_10555	COG1653	transport
AWN88_10560	COG0523	cobalamin synthesis protein
AWN88_10575	COG0523	cobalamin synthesis protein
AWN88_10580	COG1121	(ABC) transporter
AWN88_10590	COG0803	Belongs to the bacterial solute-binding protein 9 family
AWN88_10595	COG1609	Transcriptional regulator
AWN88_10610	COG2084	Dehydrogenase
AWN88_10615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_10625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWN88_10630	COG0583	DNA-binding transcription factor activity
AWN88_10635	COG2223	nitrite transmembrane transporter activity
AWN88_10670	COG0667	Aldo Keto reductase
AWN88_10685	COG2186	Transcriptional regulator
AWN88_10690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWN88_10695	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AWN88_10700	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_10705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_10710	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_10715	COG3618	amidohydrolase
AWN88_10720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_10740	COG1175	transmembrane transport
AWN88_10745	COG0395	ABC-type sugar transport system, permease component
AWN88_10765	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AWN88_10770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWN88_10795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AWN88_10805	COG1278	Cold shock
AWN88_10810	COG0673	inositol 2-dehydrogenase activity
AWN88_10825	COG0673	inositol 2-dehydrogenase activity
AWN88_10830	COG1309	transcriptional regulator
AWN88_10835	COG1653	transport
AWN88_10840	COG1175	transmembrane transport
AWN88_10845	COG0395	ABC-type sugar transport system, permease component
AWN88_10850	COG3842	ATPase activity
AWN88_10870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AWN88_10910	COG1175	transmembrane transport
AWN88_10915	COG0395	ABC-type sugar transport system, permease component
AWN88_10920	COG1116	anion transmembrane transporter activity
AWN88_10925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_10930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_10940	COG3842	ATPase activity
AWN88_10945	COG0395	ABC-type sugar transport system, permease component
AWN88_10950	COG1175	transmembrane transport
AWN88_10955	COG1653	transport
AWN88_10990	COG2186	Transcriptional regulator
AWN88_10995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_11000	COG0765	amino acid transport
AWN88_11015	COG3842	ATPase activity
AWN88_11025	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_11030	COG0395	ABC-type sugar transport system, permease component
AWN88_11055	COG2233	PERMEase
AWN88_11060	COG1049	propionate catabolic process, 2-methylcitrate cycle
AWN88_11065	COG0840	transmembrane signaling receptor activity
AWN88_11075	COG0110	maltose O-acetyltransferase activity
AWN88_11105	COG4297	protein containing double-stranded beta helix domain
AWN88_11190	COG4178	(ABC) transporter
AWN88_11195	COG4178	(ABC) transporter
AWN88_11305	COG0330	HflC and HflK could
AWN88_11350	COG0601	transmembrane transport
AWN88_11355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_11360	COG0444	Belongs to the ABC transporter superfamily
AWN88_11370	COG0747	negative chemotaxis
AWN88_11380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AWN88_11385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AWN88_11395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AWN88_11400	COG0583	DNA-binding transcription factor activity
AWN88_11410	COG0737	Belongs to the 5'-nucleotidase family
AWN88_11435	COG2897	thiosulfate sulfurtransferase activity
AWN88_11450	COG0415	Belongs to the DNA photolyase family
AWN88_11460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWN88_11490	COG3932	Exopolysaccharide synthesis, ExoD
AWN88_11495	COG1238	metal cluster binding
AWN88_11565	COG1612	heme a metabolic process
AWN88_11575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AWN88_11580	COG0010	Belongs to the arginase family
AWN88_11585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AWN88_11590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AWN88_11600	COG1832	CoA-binding protein
AWN88_11620	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_11625	COG2124	cytochrome p450
AWN88_11635	COG0740	serine-type endopeptidase activity
AWN88_11640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AWN88_11645	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AWN88_11655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AWN88_11675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWN88_11680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWN88_11685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWN88_11695	COG0649	NAD binding
AWN88_11705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AWN88_11710	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AWN88_11720	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AWN88_11725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AWN88_11735	COG0713	ATP synthesis coupled electron transport
AWN88_11750	COG1007	ATP synthesis coupled electron transport
AWN88_11755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AWN88_11755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AWN88_11770	COG0442	prolyl-tRNA aminoacylation
AWN88_11780	COG1136	(ABC) transporter
AWN88_11785	COG0587	DNA-directed DNA polymerase activity
AWN88_11795	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AWN88_11805	COG0784	Response regulator, receiver
AWN88_11810	COG3706	GGDEF domain
AWN88_11810	COG0745	RESPONSE REGULATOR receiver
AWN88_11815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AWN88_11820	COG0477	Major facilitator Superfamily
AWN88_11835	COG0557	exoribonuclease II activity
AWN88_11840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AWN88_11850	COG0758	DNA mediated transformation
AWN88_11855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AWN88_11860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AWN88_11865	COG0540	Belongs to the ATCase OTCase family
AWN88_11870	COG1960	acyl-CoA dehydrogenase activity
AWN88_11875	COG0456	acetyltransferase
AWN88_11890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AWN88_11895	COG2824	Alkylphosphonate utilization operon protein PhnA
AWN88_11900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AWN88_11905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWN88_11910	COG0154	amidase activity
AWN88_11915	COG0456	acetyltransferase
AWN88_11920	COG3811	Belongs to the UPF0386 family
AWN88_11935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AWN88_11945	COG0456	acetyltransferase
AWN88_11960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AWN88_11965	COG0439	Biotin carboxylase
AWN88_11970	COG0511	ligase activity, forming carbon-carbon bonds
AWN88_11975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AWN88_11985	COG0436	Aminotransferase
AWN88_12005	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_12010	COG1530	ribonuclease E activity
AWN88_12020	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AWN88_12040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AWN88_12045	COG0384	phenazine biosynthesis protein PhzF
AWN88_12060	COG0633	Ferredoxin
AWN88_12075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AWN88_12080	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AWN88_12090	COG3768	UPF0283 membrane protein
AWN88_12095	COG3106	COG3106 Predicted ATPase
AWN88_12105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AWN88_12120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AWN88_12145	COG0583	DNA-binding transcription factor activity
AWN88_12155	COG0537	adenosine 5'-monophosphoramidase activity
AWN88_12180	COG0052	Belongs to the universal ribosomal protein uS2 family
AWN88_12185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AWN88_12190	COG0528	UMP kinase activity
AWN88_12195	COG0233	cytoplasmic translational termination
AWN88_12200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AWN88_12205	COG0575	Belongs to the CDS family
AWN88_12210	COG0750	zinc metalloprotease
AWN88_12215	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AWN88_12220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AWN88_12225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWN88_12230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AWN88_12235	COG3494	Protein of unknown function (DUF1009)
AWN88_12240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AWN88_12245	COG0372	Belongs to the citrate synthase family
AWN88_12260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AWN88_12285	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AWN88_12290	COG0148	phosphopyruvate hydratase activity
AWN88_12300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AWN88_12305	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWN88_12305	COG0022	dehydrogenase e1 component
AWN88_12310	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWN88_12320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AWN88_12330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AWN88_12335	COG0697	spore germination
AWN88_12350	COG2867	negative regulation of translational initiation
AWN88_12360	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AWN88_12360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AWN88_12370	COG3852	Histidine kinase
AWN88_12375	COG2204	response regulator
AWN88_12380	COG5000	phosphorelay sensor kinase activity
AWN88_12385	COG2204	response regulator
AWN88_12390	COG0569	domain protein
AWN88_12395	COG1923	regulation of RNA biosynthetic process
AWN88_12400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AWN88_12435	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AWN88_12445	COG0667	Aldo Keto reductase
AWN88_12460	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AWN88_12465	COG1121	(ABC) transporter
AWN88_12470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AWN88_12485	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWN88_12490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AWN88_12500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AWN88_12505	COG0629	single-stranded DNA binding
AWN88_12515	COG2095	MarC family integral membrane protein
AWN88_12520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWN88_12570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AWN88_12580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWN88_12585	COG0084	hydrolase, TatD family'
AWN88_12590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AWN88_12590	COG0321	lipoyl(octanoyl) transferase activity
AWN88_12610	COG0625	glutathione transferase activity
AWN88_12615	COG0450	alkyl hydroperoxide reductase
AWN88_12625	COG1671	Belongs to the UPF0178 family
AWN88_12635	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AWN88_12640	COG0251	oxidation-reduction process
AWN88_12665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AWN88_12690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AWN88_12695	COG0509	glycine decarboxylation via glycine cleavage system
AWN88_12700	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWN88_12700	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AWN88_12705	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AWN88_12745	COG1648	precorrin-2 dehydrogenase activity
AWN88_12745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWN88_12755	COG3956	TIGRFAM MazG family protein
AWN88_12800	COG2239	Acts as a magnesium transporter
AWN88_12805	COG0243	molybdopterin cofactor binding
AWN88_12815	COG0242	peptide deformylase activity
AWN88_12825	COG2205	protein histidine kinase activity
AWN88_12825	COG2202	Pas domain
AWN88_12835	COG0321	lipoyl(octanoyl) transferase activity
AWN88_12840	COG1064	alcohol dehydrogenase
AWN88_12890	COG2124	cytochrome p450
AWN88_12905	COG2267	carboxylic ester hydrolase activity
AWN88_12915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_12920	COG0626	cystathionine gamma-synthase activity
AWN88_12925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_12930	COG4597	amino acid ABC transporter
AWN88_12935	COG0765	amino acid transport
AWN88_12940	COG1126	abc transporter atp-binding protein
AWN88_12970	COG0436	Aminotransferase
AWN88_13000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWN88_13010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWN88_13015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWN88_13020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWN88_13035	COG3243	poly(R)-hydroxyalkanoic acid synthase
AWN88_13040	COG1489	DNA binding
AWN88_13045	COG0024	Methionine aminopeptidase
AWN88_13050	COG2003	Belongs to the UPF0758 family
AWN88_13065	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AWN88_13085	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AWN88_13090	COG0546	phosphoglycolate phosphatase activity
AWN88_13100	COG0114	fumarate hydratase activity
AWN88_13105	COG0504	CTP synthase activity
AWN88_13115	COG0149	triose-phosphate isomerase activity
AWN88_13125	COG0187	DNA topoisomerase II activity
AWN88_13130	COG0740	serine-type endopeptidase activity
AWN88_13140	COG0640	Transcriptional regulator
AWN88_13145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWN88_13160	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AWN88_13160	COG3264	Mechanosensitive ion channel
AWN88_13215	COG1127	ABC transporter
AWN88_13220	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AWN88_13225	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_13235	COG0280	phosphate acetyltransferase
AWN88_13235	COG0281	malic enzyme
AWN88_13240	COG0346	lactoylglutathione lyase activity
AWN88_13250	COG0778	Nitroreductase
AWN88_13255	COG0823	Involved in the tonB-independent uptake of proteins
AWN88_13270	COG1368	sulfuric ester hydrolase activity
AWN88_13300	COG0544	peptidyl-prolyl cis-trans isomerase activity
AWN88_13310	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AWN88_13330	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AWN88_13355	COG0512	Glutamine amidotransferase of anthranilate synthase
AWN88_13355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWN88_13360	COG0343	queuine tRNA-ribosyltransferase activity
AWN88_13365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AWN88_13370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWN88_13375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AWN88_13380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AWN88_13395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AWN88_13400	COG0134	indole-3-glycerol-phosphate synthase activity
AWN88_13405	COG0315	cyclic pyranopterin monophosphate synthase activity
AWN88_13410	COG0303	'Molybdopterin
AWN88_13415	COG3706	GGDEF domain
AWN88_13425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AWN88_13425	COG0475	glutathione-regulated potassium exporter activity
AWN88_13435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AWN88_13440	COG0697	spore germination
AWN88_13445	COG2814	Major facilitator Superfamily
AWN88_13450	COG0746	molybdenum cofactor guanylyltransferase activity
AWN88_13455	COG1763	Mo-molybdopterin cofactor biosynthetic process
AWN88_13460	COG0739	heme binding
AWN88_13465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AWN88_13470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AWN88_13475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWN88_13480	COG0805	protein transport
AWN88_13485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWN88_13490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AWN88_13495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AWN88_13500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AWN88_13505	COG1472	Belongs to the glycosyl hydrolase 3 family
AWN88_13515	COG0018	arginyl-trna synthetase
AWN88_13520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AWN88_13525	COG0316	Belongs to the HesB IscA family
AWN88_13545	COG0525	valine-tRNA ligase activity
AWN88_13555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AWN88_13575	COG0655	NAD(P)H dehydrogenase (quinone) activity
AWN88_13580	COG1546	Belongs to the CinA family
AWN88_13580	COG1058	Belongs to the CinA family
AWN88_13585	COG0589	response to stress
AWN88_13590	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AWN88_13595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWN88_13610	COG1914	H( )-stimulated, divalent metal cation uptake system
AWN88_13625	COG1132	(ABC) transporter
AWN88_13630	COG0628	permease
AWN88_13665	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AWN88_13675	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AWN88_13685	COG0302	gtp cyclohydrolase
AWN88_13690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AWN88_13695	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWN88_13700	COG0517	IMP dehydrogenase activity
AWN88_13700	COG0516	GMP reductase activity
AWN88_13730	COG1760	l-serine dehydratase
AWN88_13760	COG0583	DNA-binding transcription factor activity
AWN88_13775	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AWN88_13775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AWN88_13780	COG0347	Belongs to the P(II) protein family
AWN88_13785	COG0174	glutamine synthetase
AWN88_13815	COG0697	spore germination
AWN88_13825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AWN88_13835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AWN88_13865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AWN88_13870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AWN88_13875	COG2186	Transcriptional regulator
AWN88_13895	COG1129	ABC transporter
AWN88_13900	COG1183	phosphatidylcholine synthase activity
AWN88_13905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_13910	COG0679	Auxin Efflux Carrier
AWN88_13915	COG0785	Cytochrome C biogenesis protein
AWN88_13940	COG1278	Cold shock
AWN88_13995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWN88_14310	COG0577	efflux transmembrane transporter activity
AWN88_14310	COG1136	(ABC) transporter
AWN88_14315	COG0577	efflux transmembrane transporter activity
AWN88_14315	COG1136	(ABC) transporter
AWN88_14335	COG2151	metal-sulfur cluster biosynthetic enzyme
AWN88_14340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AWN88_14345	COG0719	Fe-S assembly protein
AWN88_14350	COG0396	ATPase activity
AWN88_14355	COG0719	Fe-S assembly protein
AWN88_14365	COG1104	cysteine desulfurase activity
AWN88_14370	COG2945	thiolester hydrolase activity
AWN88_14375	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AWN88_14380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWN88_14390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AWN88_14395	COG2833	Protein of unknown function (DUF455)
AWN88_14400	COG0739	heme binding
AWN88_14405	COG0513	Belongs to the DEAD box helicase family
AWN88_14430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AWN88_14440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWN88_14445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWN88_14450	COG0047	phosphoribosylformylglycinamidine synthase activity
AWN88_14465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWN88_14475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AWN88_14495	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AWN88_14500	COG2814	Major facilitator Superfamily
AWN88_14505	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_14510	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_14515	COG0037	tRNA processing
AWN88_14520	COG2066	Belongs to the glutaminase family
AWN88_14525	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AWN88_14530	COG0861	Integral membrane protein TerC family
AWN88_14545	COG1280	lysine exporter protein (LysE YggA)
AWN88_14555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AWN88_14560	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AWN88_14570	COG0538	isocitrate dehydrogenase activity
AWN88_14580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AWN88_14590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AWN88_14595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_14600	COG2313	pseudouridylate synthase activity
AWN88_14610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AWN88_14615	COG4215	(ABC) transporter
AWN88_14625	COG5425	PFAM Usg family protein
AWN88_14635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_14640	COG1522	sequence-specific DNA binding
AWN88_14645	COG1573	uracil-dna glycosylase
AWN88_14655	COG2205	protein histidine kinase activity
AWN88_14655	COG2202	Pas domain
AWN88_14665	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AWN88_14670	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AWN88_14685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AWN88_14690	COG0842	Transport permease protein
AWN88_14695	COG1131	(ABC) transporter
AWN88_14710	COG0840	transmembrane signaling receptor activity
AWN88_14720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AWN88_14725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWN88_14740	COG0129	dihydroxy-acid dehydratase activity
AWN88_14745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AWN88_14750	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AWN88_14755	COG0203	ribosomal protein L17
AWN88_14760	COG0202	RNA polymerase activity
AWN88_14765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AWN88_14770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AWN88_14775	COG0563	adenylate kinase activity
AWN88_14780	COG0201	protein transport
AWN88_14785	COG0200	Binds to the 23S rRNA
AWN88_14790	COG1841	ribosomal large subunit assembly
AWN88_14795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AWN88_14800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AWN88_14805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AWN88_14810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AWN88_14815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AWN88_14820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AWN88_14825	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AWN88_14830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AWN88_14835	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AWN88_14840	COG0255	Belongs to the universal ribosomal protein uL29 family
AWN88_14845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AWN88_14850	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AWN88_14855	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AWN88_14860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AWN88_14865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AWN88_14870	COG0089	rRNA binding
AWN88_14875	COG0088	Forms part of the polypeptide exit tunnel
AWN88_14880	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AWN88_14885	COG0051	transcription antitermination factor activity, RNA binding
AWN88_14890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWN88_14895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AWN88_14900	COG0049	tRNA binding
AWN88_14905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AWN88_14925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AWN88_14930	COG0085	RNA polymerase activity
AWN88_14935	COG0222	ribosome binding
AWN88_14940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AWN88_14945	COG0081	regulation of translation
AWN88_14950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AWN88_14970	COG1086	Polysaccharide biosynthesis protein
AWN88_14975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AWN88_14980	COG0861	Integral membrane protein TerC family
AWN88_15010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWN88_15015	COG1607	acyl-coa hydrolase
AWN88_15030	COG2910	NAD(P)H-binding
AWN88_15050	COG0556	nucleotide-excision repair
AWN88_15060	COG2382	esterase
AWN88_15080	COG0484	heat shock protein binding
AWN88_15110	COG4149	molybdate abc transporter
AWN88_15115	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_15120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWN88_15125	COG4154	Belongs to the RbsD FucU family
AWN88_15135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AWN88_15145	COG2207	Transcriptional regulator
AWN88_15150	COG1064	alcohol dehydrogenase
AWN88_15155	COG1252	NADH dehydrogenase
AWN88_15160	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AWN88_15170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AWN88_15195	COG0656	L-ascorbic acid biosynthetic process
AWN88_15210	COG0440	acetolactate synthase activity
AWN88_15215	COG0028	Belongs to the TPP enzyme family
AWN88_15225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AWN88_15230	COG0560	Phosphoserine phosphatase
AWN88_15240	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_15250	COG0330	HflC and HflK could
AWN88_15255	COG0330	HflC and HflK could
AWN88_15265	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AWN88_15300	COG0277	FAD linked oxidase domain protein
AWN88_15305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWN88_15345	COG1335	isochorismatase
AWN88_15370	COG2264	protein methyltransferase activity
AWN88_15375	COG1999	signal sequence binding
AWN88_15380	COG0835	chemotaxis
AWN88_15390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AWN88_15395	COG0583	DNA-binding transcription factor activity
AWN88_15405	COG1247	-acetyltransferase
AWN88_15415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AWN88_15420	COG0497	DNA recombination
AWN88_15425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AWN88_15435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AWN88_15440	COG0849	cell division
AWN88_15445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AWN88_15450	COG1181	Belongs to the D-alanine--D-alanine ligase family
AWN88_15455	COG0477	Major facilitator Superfamily
AWN88_15460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AWN88_15465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AWN88_15470	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AWN88_15480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AWN88_15485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AWN88_15495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AWN88_15510	COG0275	rRNA processing
AWN88_15515	COG2001	Belongs to the MraZ family
AWN88_15540	COG3023	N-Acetylmuramoyl-L-alanine amidase
AWN88_15545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AWN88_15570	COG4106	trans-aconitate 2-methyltransferase activity
AWN88_15600	COG2267	carboxylic ester hydrolase activity
AWN88_15605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AWN88_15620	COG0251	oxidation-reduction process
AWN88_15635	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_15640	COG2814	Major facilitator Superfamily
AWN88_15660	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_15665	COG0174	glutamine synthetase
AWN88_15670	COG0531	amino acid
AWN88_15680	COG1737	Transcriptional regulator
AWN88_15690	COG1178	ABC-type Fe3 transport system permease component
AWN88_15700	COG3842	ATPase activity
AWN88_15755	COG2968	Membrane
AWN88_15765	COG0432	Pfam Uncharacterised protein family UPF0047
AWN88_15780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWN88_15785	COG0358	DNA primase activity
AWN88_15805	COG0505	Belongs to the CarA family
AWN88_15810	COG0534	Mate efflux family protein
AWN88_15825	COG2321	neutral zinc metallopeptidase
AWN88_15840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AWN88_15850	COG3706	GGDEF domain
AWN88_15855	COG1573	uracil-dna glycosylase
AWN88_15865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AWN88_15875	COG1522	sequence-specific DNA binding
AWN88_15880	COG0492	ferredoxin-NADP+ reductase activity
AWN88_15885	COG0583	DNA-binding transcription factor activity
AWN88_15895	COG1902	pentaerythritol trinitrate reductase activity
AWN88_15920	COG0387	Pfam Sodium calcium exchanger
AWN88_15945	COG1278	Cold shock
AWN88_15950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AWN88_15960	COG1846	Transcriptional regulator
AWN88_15965	COG0745	RESPONSE REGULATOR receiver
AWN88_15970	COG2205	protein histidine kinase activity
AWN88_15975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWN88_15995	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AWN88_16020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AWN88_16030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AWN88_16045	COG0840	transmembrane signaling receptor activity
AWN88_16050	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_16060	COG3300	MHYT domain
AWN88_16060	COG5001	Diguanylate cyclase
AWN88_16065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AWN88_16070	COG5001	Diguanylate cyclase
AWN88_16080	COG0193	aminoacyl-tRNA hydrolase activity
AWN88_16090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AWN88_16110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AWN88_16115	COG2857	Cytochrome c1
AWN88_16115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AWN88_16135	COG1132	(ABC) transporter
AWN88_16140	COG1132	(ABC) transporter
AWN88_16150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AWN88_16165	COG0408	coproporphyrinogen oxidase activity
AWN88_16180	COG0617	tRNA 3'-terminal CCA addition
AWN88_16195	COG0714	Associated with various cellular activities
AWN88_16215	COG0454	-acetyltransferase
AWN88_16230	COG0477	Major facilitator Superfamily
AWN88_16240	COG0435	Glutathione S-transferase
AWN88_16255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AWN88_16270	COG3135	benzoate transporter
AWN88_16295	COG0740	serine-type endopeptidase activity
AWN88_16310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AWN88_16315	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AWN88_16340	COG4175	Glycine betaine
AWN88_16355	COG1435	thymidine kinase activity
AWN88_16375	COG2862	Uncharacterized protein family, UPF0114
AWN88_16380	COG1629	transport
AWN88_16380	COG4771	TonB-dependent receptor
AWN88_16390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AWN88_16390	COG0512	Glutamine amidotransferase of anthranilate synthase
AWN88_16405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AWN88_16420	COG0366	Alpha amylase catalytic
AWN88_16425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_16440	COG1160	GTP binding
AWN88_16460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AWN88_16470	COG0024	Methionine aminopeptidase
AWN88_16480	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_16490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AWN88_16500	COG0583	DNA-binding transcription factor activity
AWN88_16515	COG0402	S-adenosylhomocysteine deaminase activity
AWN88_16525	COG1304	FMN binding
AWN88_16535	COG1309	transcriptional regulator
AWN88_16540	COG1686	Belongs to the peptidase S11 family
AWN88_16550	COG2351	hydroxyisourate hydrolase activity
AWN88_16555	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AWN88_16580	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AWN88_16590	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AWN88_16590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_16595	COG2205	protein histidine kinase activity
AWN88_16595	COG5002	protein histidine kinase activity
AWN88_16595	COG0784	Response regulator, receiver
AWN88_16600	COG0513	Belongs to the DEAD box helicase family
AWN88_16610	COG2259	Doxx family
AWN88_16615	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_16625	COG2308	Evidence 4 Homologs of previously reported genes of
AWN88_16635	COG1305	Transglutaminase-like
AWN88_16655	COG0588	phosphoglycerate mutase activity
AWN88_16665	COG4214	carbohydrate transport
AWN88_16675	COG4213	ABC transporter substrate-binding protein
AWN88_16710	COG0840	transmembrane signaling receptor activity
AWN88_16735	COG1215	transferase activity, transferring glycosyl groups
AWN88_16750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AWN88_16765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AWN88_16770	COG2346	COG2346, Truncated hemoglobins
AWN88_16790	COG1309	transcriptional regulator
AWN88_16805	COG0494	nUDIX hydrolase
AWN88_16815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_16820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_16845	COG1234	tRNA 3'-trailer cleavage
AWN88_16850	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AWN88_16855	COG0830	nickel cation binding
AWN88_16860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AWN88_16875	COG0804	urea catabolic process
AWN88_16880	COG1442	glycosyl transferase family 8
AWN88_16885	COG3755	Protein conserved in bacteria
AWN88_16895	COG0832	Belongs to the urease beta subunit family
AWN88_16900	COG3813	Protein conserved in bacteria
AWN88_16905	COG0831	urea catabolic process
AWN88_16910	COG0829	nickel cation binding
AWN88_16925	COG0411	ABC transporter
AWN88_16935	COG0559	Belongs to the binding-protein-dependent transport system permease family
AWN88_16955	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_16960	COG0784	Response regulator, receiver
AWN88_16960	COG2198	Histidine kinase
AWN88_16960	COG5002	protein histidine kinase activity
AWN88_16975	COG0726	polysaccharide deacetylase
AWN88_16995	COG0411	ABC transporter
AWN88_17010	COG1218	3'(2'),5'-bisphosphate nucleotidase
AWN88_17085	COG0564	pseudouridine synthase activity
AWN88_17095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AWN88_17105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AWN88_17130	COG0346	lactoylglutathione lyase activity
AWN88_17140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AWN88_17150	COG2832	Protein of unknown function (DUF454)
AWN88_17155	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AWN88_17160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_17165	COG4558	Periplasmic binding protein
AWN88_17175	COG3721	Heme iron utilization protein
AWN88_17195	COG2205	protein histidine kinase activity
AWN88_17235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_17240	COG4605	iron ion homeostasis
AWN88_17245	COG4604	ABC transporter, ATP-binding protein
AWN88_17250	COG0783	Belongs to the Dps family
AWN88_17265	COG0656	L-ascorbic acid biosynthetic process
AWN88_17270	COG2814	Major facilitator Superfamily
AWN88_17280	COG0583	DNA-binding transcription factor activity
AWN88_17290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_17310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AWN88_17320	COG0288	reversible hydration of carbon dioxide
AWN88_17330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AWN88_17345	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AWN88_17350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AWN88_17355	COG0778	Nitroreductase
AWN88_17360	COG2267	carboxylic ester hydrolase activity
AWN88_17365	COG0251	oxidation-reduction process
AWN88_17370	COG1335	isochorismatase
AWN88_17375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AWN88_17385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_17400	COG1175	transmembrane transport
AWN88_17405	COG0395	ABC-type sugar transport system, permease component
AWN88_17410	COG3842	ATPase activity
AWN88_17415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_17425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWN88_17440	COG4608	Belongs to the ABC transporter superfamily
AWN88_17445	COG0444	Belongs to the ABC transporter superfamily
AWN88_17455	COG0601	transmembrane transport
AWN88_17475	COG0392	lysyltransferase activity
AWN88_17475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AWN88_17505	COG0642	Histidine kinase
AWN88_17510	COG0745	RESPONSE REGULATOR receiver
AWN88_17520	COG1902	pentaerythritol trinitrate reductase activity
AWN88_17520	COG0446	pyridine nucleotide-disulphide oxidoreductase
AWN88_17530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_17555	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_17575	COG1522	sequence-specific DNA binding
AWN88_17580	COG1335	isochorismatase
AWN88_17590	COG0604	alcohol dehydrogenase
AWN88_17590	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_17590	COG3321	synthase
AWN88_17595	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_17600	COG2207	Transcriptional regulator
AWN88_17640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AWN88_17645	COG1309	transcriptional regulator
AWN88_17650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AWN88_17655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AWN88_17665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AWN88_17670	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AWN88_17675	COG1509	lysine 2,3-aminomutase activity
AWN88_17695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_17700	COG0725	ABC transporter, periplasmic molybdate-binding protein
AWN88_17705	COG4149	molybdate abc transporter
AWN88_17710	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AWN88_17725	COG2022	thiamine diphosphate biosynthetic process
AWN88_17740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AWN88_17745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWN88_17755	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AWN88_17780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWN88_17780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWN88_17825	COG4166	transmembrane transport
AWN88_17830	COG0601	transmembrane transport
AWN88_17835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AWN88_17845	COG0438	transferase activity, transferring glycosyl groups
AWN88_17855	COG3142	Participates in the control of copper homeostasis
AWN88_17860	COG2814	Major facilitator Superfamily
AWN88_17880	COG1737	Transcriptional regulator
AWN88_17890	COG3842	ATPase activity
AWN88_17900	COG0395	ABC-type sugar transport system, permease component
AWN88_17925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AWN88_17930	COG1940	carbohydrate kinase activity
AWN88_17940	COG0671	phosphoesterase, PA-phosphatase related
AWN88_17945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AWN88_17950	COG0156	8-amino-7-oxononanoate synthase activity
AWN88_17960	COG0729	surface antigen
AWN88_17970	COG0835	chemotaxis
AWN88_17980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AWN88_17985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AWN88_17990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AWN88_17995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AWN88_18000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AWN88_18005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AWN88_18020	COG4974	Belongs to the 'phage' integrase family
AWN88_18045	COG1280	lysine exporter protein (LysE YggA)
AWN88_18055	COG0508	dehydrogenase complex catalyzes the overall conversion of
AWN88_18065	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AWN88_18070	COG0045	succinate-CoA ligase (ADP-forming) activity
AWN88_18075	COG0039	L-malate dehydrogenase activity
AWN88_18080	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AWN88_18110	COG2264	protein methyltransferase activity
AWN88_18125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AWN88_18130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AWN88_18135	COG0181	hydroxymethylbilane synthase activity
AWN88_18160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWN88_18175	COG1872	DUF167
AWN88_18180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AWN88_18195	COG0339	signal peptide processing
AWN88_18205	COG1846	Transcriptional regulator
AWN88_18210	COG2814	Major facilitator Superfamily
AWN88_18215	COG0137	argininosuccinate synthase activity
AWN88_18225	COG1280	lysine exporter protein (LysE YggA)
AWN88_18235	COG4120	Belongs to the binding-protein-dependent transport system permease family
AWN88_18245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AWN88_18260	COG2154	pterin-4-alpha-carbinolamine dehydratase
AWN88_18265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AWN88_18270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AWN88_18280	COG4181	ATPase activity
AWN88_18290	COG0670	Belongs to the BI1 family
AWN88_18305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AWN88_18310	COG4133	protoheme IX ABC transporter activity
AWN88_18315	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWN88_18320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AWN88_18335	COG3706	GGDEF domain
AWN88_18345	COG2917	probably involved in intracellular septation
AWN88_18350	COG0552	protein localization to endoplasmic reticulum
AWN88_18355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWN88_18360	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AWN88_18370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AWN88_18375	COG1605	Chorismate mutase
AWN88_18375	COG0287	Prephenate dehydrogenase
AWN88_18380	COG0228	four-way junction DNA binding
AWN88_18385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AWN88_18390	COG0336	Belongs to the RNA methyltransferase TrmD family
AWN88_18400	COG0335	large ribosomal subunit rRNA binding
AWN88_18410	COG0765	amino acid transport
AWN88_18420	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AWN88_18425	COG4783	chaperone-mediated protein folding
AWN88_18430	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AWN88_18460	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AWN88_18470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AWN88_18475	COG0142	geranyltranstransferase activity
AWN88_18480	COG2885	chlorophyll binding
AWN88_18485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AWN88_18490	COG2223	nitrite transmembrane transporter activity
AWN88_18495	COG1349	DNA-binding transcription factor activity
AWN88_18500	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AWN88_18505	COG2197	response regulator
AWN88_18510	COG1132	(ABC) transporter
AWN88_18520	COG3459	Glycosyltransferase 36 associated
AWN88_18525	COG1473	amidohydrolase
AWN88_18530	COG0579	oxidoreductase
AWN88_18540	COG0129	dihydroxy-acid dehydratase activity
AWN88_18545	COG2084	Dehydrogenase
AWN88_18550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AWN88_18555	COG0277	FAD linked oxidase domain protein
AWN88_18560	COG2186	Transcriptional regulator
AWN88_18570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AWN88_18575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AWN88_18580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AWN88_18585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AWN88_18595	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AWN88_18600	COG0495	leucyl-tRNA aminoacylation
AWN88_18620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AWN88_18630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_18635	COG1946	Acyl-CoA thioesterase
AWN88_18640	COG0347	Belongs to the P(II) protein family
AWN88_18645	COG0004	ammonium transporteR
AWN88_18650	COG1674	ftsk spoiiie
AWN88_18655	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AWN88_18670	COG0745	RESPONSE REGULATOR receiver
AWN88_18680	COG1329	Transcriptional regulator
AWN88_18685	COG2902	Dehydrogenase
AWN88_18690	COG2270	Major facilitator Superfamily
AWN88_18705	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_18730	COG0793	Belongs to the peptidase S41A family
AWN88_18740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AWN88_18745	COG0799	negative regulation of ribosome biogenesis
AWN88_18750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AWN88_18755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AWN88_18760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AWN88_18765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AWN88_18780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AWN88_18785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AWN88_18810	COG0066	3-isopropylmalate dehydratase activity
AWN88_18815	COG0473	3-isopropylmalate dehydrogenase activity
AWN88_18820	COG1858	cytochrome C peroxidase
AWN88_18825	COG1797	cobyrinic acid a,c-diamide synthase activity
AWN88_18830	COG1648	precorrin-2 dehydrogenase activity
AWN88_18830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AWN88_18835	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AWN88_18900	COG1492	cobalamin metabolic process
AWN88_18915	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_18920	COG3254	rhamnose metabolic process
AWN88_18930	COG1063	alcohol dehydrogenase
AWN88_18950	COG4214	carbohydrate transport
AWN88_18955	COG1129	ABC transporter
AWN88_18960	COG2186	Transcriptional regulator
AWN88_18965	COG2721	sulfolactate sulfo-lyase activity
AWN88_18970	COG0138	bifunctional purine biosynthesis protein purh
AWN88_18980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AWN88_18980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWN88_18985	COG0501	Belongs to the peptidase M48B family
AWN88_18995	COG1475	DNA binding
AWN88_19000	COG1192	Involved in chromosome partitioning
AWN88_19005	COG0357	Ribosomal RNA small subunit methyltransferase G
AWN88_19010	COG0445	tRNA wobble uridine modification
AWN88_19015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AWN88_19020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AWN88_19030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AWN88_19035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AWN88_19040	COG0424	maF-like protein
AWN88_19045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AWN88_19050	COG0237	dephospho-CoA kinase activity
AWN88_19060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AWN88_19075	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AWN88_19090	COG0187	DNA topoisomerase II activity
AWN88_19100	COG0179	Fumarylacetoacetate (FAA) hydrolase
AWN88_19115	COG0135	phosphoribosylanthranilate isomerase activity
AWN88_19120	COG0133	tryptophan synthase activity
AWN88_19125	COG0159	tryptophan synthase activity
AWN88_19130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AWN88_19145	COG1074	ATP-dependent DNA helicase activity
AWN88_19155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AWN88_19165	COG2205	protein histidine kinase activity
AWN88_19170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AWN88_19175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWN88_19180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWN88_19180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AWN88_19185	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AWN88_19190	COG0642	Histidine kinase
AWN88_19195	COG0745	RESPONSE REGULATOR receiver
AWN88_19200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AWN88_19210	COG1652	LysM domain
AWN88_19215	COG1072	(Pantothenic acid kinase))
AWN88_19220	COG0140	phosphoribosyl-ATP diphosphatase activity
AWN88_19225	COG0107	imidazoleglycerol-phosphate synthase activity
AWN88_19230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AWN88_19235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AWN88_19245	COG0131	Imidazoleglycerol-phosphate dehydratase
AWN88_19250	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AWN88_19255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AWN88_19265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AWN88_19280	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AWN88_19290	COG1643	Atp-dependent helicase
AWN88_19350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AWN88_19365	COG0583	DNA-binding transcription factor activity
AWN88_19370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AWN88_19375	COG1780	Probably involved in ribonucleotide reductase function
AWN88_19380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AWN88_19390	COG3547	Transposase (IS116 IS110 IS902 family)
AWN88_19420	COG5489	Protein of unknown function (DUF736)
AWN88_19485	COG0741	lytic transglycosylase activity
AWN88_19485	COG0739	heme binding
AWN88_19485	COG1196	nuclear chromosome segregation
AWN88_19565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWN88_19570	COG0740	serine-type endopeptidase activity
AWN88_19580	COG0640	Transcriptional regulator
AWN88_19595	COG4773	Receptor
AWN88_19610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_19615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_19620	COG1120	ATPase activity
AWN88_19635	COG4774	siderophore transport
AWN88_19650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_19655	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AWN88_19690	COG4962	Type ii secretion system protein e
AWN88_19695	COG3838	Conjugal transfer protein Trbc
AWN88_19705	COG3451	type IV secretory pathway VirB4
AWN88_19735	COG2948	multi-organism process
AWN88_19755	COG0425	Belongs to the sulfur carrier protein TusA family
AWN88_19760	COG1674	ftsk spoiiie
AWN88_19765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWN88_19825	COG0024	Methionine aminopeptidase
AWN88_19835	COG2814	Major facilitator Superfamily
AWN88_19860	COG0625	glutathione transferase activity
AWN88_19865	COG2814	Major facilitator Superfamily
AWN88_19870	COG1309	transcriptional regulator
AWN88_19895	COG0583	DNA-binding transcription factor activity
AWN88_19915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AWN88_19920	COG1959	2 iron, 2 sulfur cluster binding
AWN88_19925	COG3634	alkyl hydroperoxide reductase activity
AWN88_19940	COG0514	ATP-dependent DNA helicase (RecQ)
AWN88_19965	COG1072	(Pantothenic acid kinase))
AWN88_19975	COG1780	Probably involved in ribonucleotide reductase function
AWN88_19995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AWN88_20020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_20030	COG2813	Specifically methylates the guanine in position
AWN88_20035	COG1185	polyribonucleotide nucleotidyltransferase activity
AWN88_20040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AWN88_20045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AWN88_20050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AWN88_20055	COG3064	Membrane
AWN88_20055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AWN88_20070	COG0779	Required for maturation of 30S ribosomal subunits
AWN88_20075	COG2814	Major facilitator Superfamily
AWN88_20080	COG2951	lytic endotransglycosylase activity
AWN88_20085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AWN88_20095	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AWN88_20100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AWN88_20115	COG2816	NAD+ diphosphatase activity
AWN88_20120	COG1605	Chorismate mutase
AWN88_20120	COG0077	Prephenate dehydratase
AWN88_20125	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AWN88_20130	COG3474	cytochrome
AWN88_20140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AWN88_20145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AWN88_20150	COG1278	Cold shock
AWN88_20155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWN88_20165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWN88_20165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AWN88_20175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AWN88_20205	COG2900	Belongs to the SlyX family
AWN88_20215	COG0484	heat shock protein binding
AWN88_20220	COG0443	Heat shock 70 kDa protein
AWN88_20235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWN88_20260	COG0295	cytidine deaminase activity
AWN88_20265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AWN88_20270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AWN88_20275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AWN88_20285	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AWN88_20290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AWN88_20295	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AWN88_20305	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AWN88_20310	COG1845	cytochrome c oxidase, subunit III
AWN88_20315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWN88_20320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AWN88_20325	COG0477	Major facilitator Superfamily
AWN88_20330	COG0070	glutamate synthase
AWN88_20330	COG0069	glutamate synthase activity
AWN88_20330	COG0067	glutamate synthase
AWN88_20335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AWN88_20350	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWN88_20360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AWN88_20390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_20410	COG0848	biopolymer transport protein
AWN88_20420	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AWN88_20435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AWN88_20440	COG3454	Phosphonate metabolism
AWN88_20445	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AWN88_20450	COG3639	organic phosphonate transmembrane transporter activity
AWN88_20455	COG3639	organic phosphonate transmembrane transporter activity
AWN88_20460	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
AWN88_20465	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AWN88_20475	COG4778	phosphonate C-P lyase system protein PhnL
AWN88_20480	COG4107	phosphonate C-P lyase system protein PhnK
AWN88_20485	COG3627	carbon phosphorus lyase activity
AWN88_20490	COG3626	phosphonate metabolism
AWN88_20495	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
AWN88_20500	COG3624	Phosphonate C-P lyase system protein PhnG
AWN88_20505	COG2188	Transcriptional regulator
AWN88_20510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AWN88_20515	COG0837	glucose binding
AWN88_20520	COG1803	Methylglyoxal synthase
AWN88_20525	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
AWN88_20530	COG4166	transmembrane transport
AWN88_20535	COG4174	ABC transporter (Permease)
AWN88_20540	COG4239	(ABC) transporter, permease
AWN88_20545	COG4172	Belongs to the ABC transporter superfamily
AWN88_20550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_20555	COG0174	glutamine synthetase
AWN88_20560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_20565	COG3265	gluconokinase activity
AWN88_20570	COG1174	glycine betaine transport
AWN88_20575	COG1125	glycine betaine transport
AWN88_20580	COG1174	glycine betaine transport
AWN88_20585	COG1732	Glycine betaine
AWN88_20595	COG1959	2 iron, 2 sulfur cluster binding
AWN88_20600	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_20615	COG0697	spore germination
AWN88_20630	COG0791	NLP P60 protein
AWN88_20635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AWN88_20640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AWN88_20675	COG4964	Belongs to the GSP D family
AWN88_20720	COG3422	double-strand break repair
AWN88_20725	COG3757	hydrolase, family 25
AWN88_20730	COG0697	spore germination
AWN88_20735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AWN88_20765	COG0481	GTPase activity
AWN88_20770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AWN88_20785	COG1396	sequence-specific DNA binding
AWN88_20800	COG1917	Cupin 2, conserved barrel domain protein
AWN88_20800	COG2169	Transcriptional regulator
AWN88_20805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AWN88_20830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AWN88_20835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AWN88_20840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AWN88_20850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AWN88_20855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AWN88_20855	COG0072	phenylalanine-tRNA ligase activity
AWN88_20860	COG0667	Aldo Keto reductase
AWN88_20880	COG4977	sequence-specific DNA binding
AWN88_20905	COG1570	exodeoxyribonuclease VII activity
AWN88_20910	COG4948	Mandelate Racemase Muconate Lactonizing
AWN88_20920	COG1846	Transcriptional regulator
AWN88_20925	COG0697	spore germination
AWN88_20930	COG2309	aminopeptidase activity
AWN88_20940	COG1393	Belongs to the ArsC family
AWN88_20960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AWN88_20960	COG0519	Catalyzes the synthesis of GMP from XMP
AWN88_20975	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AWN88_21005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AWN88_21015	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AWN88_21025	COG1968	undecaprenyl-diphosphatase activity
AWN88_21040	COG0284	orotidine-5'-phosphate decarboxylase activity
AWN88_21050	COG3963	phosphatidate phosphatase activity
AWN88_21055	COG0592	DNA-directed DNA polymerase activity
AWN88_21060	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AWN88_21065	COG0792	nuclease activity
AWN88_21075	COG1653	transport
AWN88_21080	COG1175	transmembrane transport
AWN88_21090	COG3842	ATPase activity
AWN88_21100	COG0189	ligase activity
AWN88_21110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AWN88_21115	COG1280	lysine exporter protein (LysE YggA)
AWN88_21120	COG0756	dUTP diphosphatase activity
AWN88_21125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AWN88_21130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AWN88_21145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AWN88_21150	COG2226	methyltransferase
AWN88_21155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AWN88_21160	COG1024	Enoyl-CoA hydratase
AWN88_21165	COG0268	Binds directly to 16S ribosomal RNA
AWN88_21170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AWN88_21175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AWN88_21180	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AWN88_21185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AWN88_21190	COG1420	regulation of RNA biosynthetic process
AWN88_21195	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AWN88_21200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AWN88_21205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AWN88_21215	COG1137	ATPase activity
AWN88_21220	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AWN88_21230	COG0616	signal peptide processing
AWN88_21235	COG0776	regulation of translation
AWN88_21245	COG0116	Belongs to the methyltransferase superfamily
AWN88_21245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AWN88_21250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AWN88_21255	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AWN88_21270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AWN88_21275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AWN88_21280	COG0728	peptidoglycan biosynthetic process
AWN88_21290	COG0180	Tryptophanyl-tRNA synthetase
AWN88_21300	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AWN88_21305	COG1214	PFAM Peptidase M22, glycoprotease
AWN88_21310	COG0456	acetyltransferase
AWN88_21325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AWN88_21330	COG1702	phosphate starvation-inducible protein PhoH
AWN88_21335	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AWN88_21345	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AWN88_21350	COG1396	sequence-specific DNA binding
AWN88_21355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AWN88_21360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AWN88_21365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AWN88_21375	COG0242	peptide deformylase activity
AWN88_21380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AWN88_21385	COG0101	tRNA pseudouridine synthase activity
AWN88_21395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AWN88_21400	COG2171	N-acyltransferase activity
AWN88_21410	COG0840	transmembrane signaling receptor activity
AWN88_21420	COG0071	Belongs to the small heat shock protein (HSP20) family
AWN88_21445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AWN88_21455	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AWN88_21460	COG0706	membrane insertase activity
AWN88_21465	COG0594	ribonuclease P activity
AWN88_21470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AWN88_21475	COG0840	transmembrane signaling receptor activity
AWN88_21490	COG2226	methyltransferase
AWN88_21495	COG3842	ATPase activity
AWN88_21500	COG1175	transmembrane transport
AWN88_21505	COG0395	ABC-type sugar transport system, permease component
AWN88_21520	COG0427	acetyl-CoA hydrolase
AWN88_21530	COG3938	Belongs to the proline racemase family
AWN88_21535	COG0418	dihydroorotase activity
AWN88_21540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AWN88_21560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWN88_21565	COG0166	Belongs to the GPI family
AWN88_21570	COG0318	PFAM AMP-dependent synthetase and ligase
AWN88_21575	COG3842	ATPase activity
AWN88_21580	COG1840	ABC-type Fe3 transport system, periplasmic component
AWN88_21585	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AWN88_21590	COG4774	siderophore transport
AWN88_21670	COG2326	polyphosphate kinase activity
AWN88_21675	COG5002	protein histidine kinase activity
AWN88_21680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AWN88_21685	COG0573	inorganic phosphate transmembrane transporter activity
AWN88_21695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AWN88_21700	COG0704	Plays a role in the regulation of phosphate uptake
AWN88_21705	COG0745	RESPONSE REGULATOR receiver
AWN88_21715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AWN88_21720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AWN88_21725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AWN88_21730	COG2967	ApaG domain
AWN88_21740	COG0717	Belongs to the dCTP deaminase family
AWN88_21750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AWN88_21780	COG0726	polysaccharide deacetylase
AWN88_21800	COG0167	dihydroorotate dehydrogenase activity
AWN88_21815	COG2264	protein methyltransferase activity
AWN88_21835	COG1959	2 iron, 2 sulfur cluster binding
AWN88_21840	COG1201	RNA secondary structure unwinding
AWN88_21870	COG1960	acyl-CoA dehydrogenase activity
AWN88_21875	COG0183	Belongs to the thiolase family
AWN88_21880	COG1250	3-hydroxyacyl-CoA dehydrogenase
AWN88_21880	COG1024	Enoyl-CoA hydratase
AWN88_21900	COG1320	monovalent cation:proton antiporter activity
AWN88_21905	COG2212	antiporter activity
AWN88_21910	COG1863	multisubunit Na H antiporter MnhE subunit
AWN88_21915	COG0651	ATP synthesis coupled electron transport
AWN88_21920	COG1006	Multisubunit Na H antiporter MnhC subunit
AWN88_21925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AWN88_21925	COG2111	Na H antiporter
AWN88_21935	COG0840	transmembrane signaling receptor activity
AWN88_21950	COG0643	Histidine kinase
AWN88_21950	COG2198	Histidine kinase
AWN88_21955	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AWN88_21960	COG2201	protein-glutamate methylesterase activity
AWN88_21965	COG0745	RESPONSE REGULATOR receiver
AWN88_21970	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AWN88_21980	COG1766	The M ring may be actively involved in energy transduction
AWN88_21985	COG2771	luxR family
AWN88_21995	COG2972	Histidine kinase
AWN88_21995	COG0840	transmembrane signaling receptor activity
AWN88_22000	COG2198	Histidine kinase
AWN88_22000	COG0784	Response regulator, receiver
AWN88_22000	COG2205	protein histidine kinase activity
AWN88_22005	COG1970	mechanosensitive ion channel activity
AWN88_22025	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AWN88_22030	COG0424	maF-like protein
AWN88_22035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AWN88_22045	COG5328	Belongs to the UPF0262 family
AWN88_22050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AWN88_22060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AWN88_22090	COG1338	Plays a role in the flagellum-specific transport system
AWN88_22100	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AWN88_22110	COG1706	bacterial-type flagellum-dependent cell motility
AWN88_22115	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
AWN88_22120	COG4786	Flagellar basal body rod
AWN88_22125	COG1677	Flagellar hook-basal body complex protein FliE
AWN88_22130	COG1558	bacterial-type flagellum-dependent cell motility
AWN88_22135	COG1815	bacterial-type flagellum-dependent cell motility
AWN88_22145	COG1157	protein secretion by the type III secretion system
AWN88_22150	COG4786	Flagellar basal body rod
AWN88_22160	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AWN88_22165	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWN88_22170	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWN88_22175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AWN88_22180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWN88_22190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AWN88_22200	COG1360	Flagellar Motor Protein
AWN88_22225	COG1749	Flagellar hook protein flgE
AWN88_22245	COG5443	negative regulation of bacterial-type flagellum assembly
AWN88_22250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AWN88_22260	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AWN88_22300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AWN88_22305	COG1609	Transcriptional regulator
AWN88_22310	COG1653	transport
AWN88_22315	COG1175	transmembrane transport
AWN88_22320	COG0395	ABC-type sugar transport system, permease component
AWN88_22325	COG0366	Alpha amylase catalytic
AWN88_22330	COG3842	ATPase activity
AWN88_22345	COG0129	dihydroxy-acid dehydratase activity
AWN88_22350	COG0363	glucosamine-6-phosphate deaminase activity
AWN88_22355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AWN88_22360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AWN88_22370	COG2081	HI0933 family
AWN88_22395	COG2224	Isocitrate lyase
AWN88_22410	COG3842	ATPase activity
AWN88_22415	COG1176	ABC-type spermidine putrescine transport system, permease component I
AWN88_22420	COG1177	transmembrane transport
AWN88_22430	COG2205	protein histidine kinase activity
AWN88_22460	COG1401	restriction endodeoxyribonuclease activity
AWN88_22695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AWN88_22730	COG0248	Ppx GppA phosphatase
AWN88_22735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AWN88_22740	COG0477	Major facilitator Superfamily
AWN88_22770	COG0521	Mo-molybdopterin cofactor biosynthetic process
AWN88_22775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AWN88_22785	COG0142	geranyltranstransferase activity
AWN88_22795	COG0357	Ribosomal RNA small subunit methyltransferase G
AWN88_22810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AWN88_22815	COG0752	glycyl-tRNA synthetase alpha subunit
AWN88_22825	COG1704	LemA family
AWN88_22830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AWN88_22840	COG0751	glycine-tRNA ligase activity
AWN88_22845	COG3657	addiction module killer protein
AWN88_22855	COG0840	transmembrane signaling receptor activity
AWN88_22865	COG0151	Belongs to the GarS family
AWN88_22870	COG2183	response to ionizing radiation
AWN88_22875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AWN88_22885	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AWN88_22900	COG0583	DNA-binding transcription factor activity
AWN88_22920	COG0306	phosphate transporter
AWN88_22930	COG0561	phosphatase activity
AWN88_22935	COG0438	transferase activity, transferring glycosyl groups
AWN88_22940	COG2186	Transcriptional regulator
AWN88_22950	COG0583	DNA-binding transcription factor activity
AWN88_22955	COG0277	FAD linked oxidase domain protein
AWN88_22960	COG0277	FAD linked oxidase domain protein
AWN88_22965	COG0247	lactate metabolic process
AWN88_22975	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_22980	COG2818	Glycosylase
AWN88_22990	COG2855	membrane
AWN88_22995	COG0583	DNA-binding transcription factor activity
AWN88_23025	COG0124	histidyl-tRNA synthetase
AWN88_23035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AWN88_23040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AWN88_23045	COG2259	Doxx family
AWN88_23055	COG0459	protein refolding
AWN88_23060	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AWN88_23070	COG0196	riboflavin kinase activity
AWN88_23075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AWN88_23085	COG0590	tRNA wobble adenosine to inosine editing
AWN88_23090	COG1187	pseudouridine synthase activity
AWN88_23095	COG0742	ribosomal rna small subunit methyltransferase
AWN88_23100	COG1752	Esterase of the alpha-beta hydrolase superfamily
AWN88_23105	COG0475	glutathione-regulated potassium exporter activity
AWN88_23105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AWN88_23110	COG0312	modulator of DNA gyrase
AWN88_23115	COG0483	inositol monophosphate 1-phosphatase activity
AWN88_23125	COG1519	Transferase
AWN88_23135	COG1663	tetraacyldisaccharide 4'-kinase activity
AWN88_23145	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AWN88_23155	COG3300	MHYT domain
AWN88_23155	COG5001	Diguanylate cyclase
AWN88_23160	COG3386	PFAM SMP-30 Gluconolaconase
AWN88_23165	COG0800	Aldolase
AWN88_23170	COG3734	2-keto-3-deoxy-galactonokinase
AWN88_23175	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_23180	COG1414	Transcriptional regulator
AWN88_23185	COG2197	response regulator
AWN88_23190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AWN88_23200	COG0598	Magnesium transport protein CorA
AWN88_23205	COG3158	transport of potassium into the cell
AWN88_23220	COG0356	it plays a direct role in the translocation of protons across the membrane
AWN88_23230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWN88_23235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AWN88_23245	COG0789	Transcriptional regulator
AWN88_23250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AWN88_23270	COG0009	L-threonylcarbamoyladenylate synthase
AWN88_23280	COG4638	Rieske (2fe-2S)
AWN88_23305	COG1960	acyl-CoA dehydrogenase activity
AWN88_23320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AWN88_23330	COG0840	transmembrane signaling receptor activity
AWN88_23340	COG1522	sequence-specific DNA binding
AWN88_23365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AWN88_23370	COG1741	Belongs to the pirin family
AWN88_23375	COG1722	exodeoxyribonuclease VII activity
AWN88_23380	COG0123	including yeast histone deacetylase and acetoin utilization protein
AWN88_23385	COG1268	BioY protein
AWN88_23390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AWN88_23395	COG1122	ATPase activity
AWN88_23400	COG3214	Protein conserved in bacteria
AWN88_23410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AWN88_23425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AWN88_23440	COG0259	pyridoxamine-phosphate oxidase activity
AWN88_23455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWN88_23465	COG0312	modulator of DNA gyrase
AWN88_23480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AWN88_23485	COG0109	protoheme IX farnesyltransferase activity
AWN88_23490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AWN88_23505	COG3346	SURF1 family
AWN88_23510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AWN88_23515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AWN88_23520	COG0328	RNA-DNA hybrid ribonuclease activity
AWN88_23530	COG0678	peroxiredoxin activity
AWN88_23530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AWN88_23540	COG1678	Uncharacterized ACR, COG1678
AWN88_23555	COG5001	Diguanylate cyclase
AWN88_23555	COG3300	MHYT domain
AWN88_23560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AWN88_23565	COG0612	Peptidase, M16
AWN88_23580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AWN88_23585	COG1802	Transcriptional regulator
AWN88_23600	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AWN88_23605	COG3609	addiction module antidote protein, CC2985 family
AWN88_23630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AWN88_23635	COG1196	nuclear chromosome segregation
AWN88_23640	COG2514	catechol 2,3-dioxygenase activity
AWN88_23645	COG0574	Belongs to the PEP-utilizing enzyme family
AWN88_23645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AWN88_23685	COG0579	oxidoreductase
AWN88_23705	COG2895	sulfate adenylyltransferase (ATP) activity
AWN88_23710	COG0175	sulfate reduction
AWN88_23715	COG0175	sulfate reduction
AWN88_23720	COG1959	2 iron, 2 sulfur cluster binding
AWN88_23725	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AWN88_23730	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AWN88_23735	COG4208	sulfate ABC transporter
AWN88_23740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AWN88_23750	COG2203	Gaf domain
AWN88_23750	COG2199	diguanylate cyclase activity
AWN88_23750	COG2200	EAL domain
AWN88_23755	COG1309	transcriptional regulator
AWN88_23760	COG1012	belongs to the aldehyde dehydrogenase family
AWN88_23765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AWN88_23800	COG0625	glutathione transferase activity
AWN88_23810	COG0477	Major facilitator Superfamily
AWN88_23820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AWN88_23820	COG1793	dna ligase
AWN88_23840	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_23845	COG1376	ErfK ybiS ycfS ynhG family protein
AWN88_23850	COG1846	Transcriptional regulator
AWN88_23855	COG1764	response to oxidative stress
AWN88_23870	COG0488	(ABC) transporter
AWN88_23905	COG4221	oxidoreductase activity
AWN88_23920	COG0433	COG0433 Predicted ATPase
AWN88_23930	COG1733	regulation of RNA biosynthetic process
AWN88_23935	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
AWN88_23945	COG1280	lysine exporter protein (LysE YggA)
AWN88_23950	COG0656	L-ascorbic acid biosynthetic process
AWN88_23955	COG3781	membrane
AWN88_23960	COG2378	regulation of single-species biofilm formation
AWN88_23970	COG4106	trans-aconitate 2-methyltransferase activity
AWN88_23975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AWN88_23980	COG0840	transmembrane signaling receptor activity
AWN88_24000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AWN88_24010	COG2378	regulation of single-species biofilm formation
AWN88_24020	COG3909	cytochrome
AWN88_24025	COG2010	Cytochrome c
AWN88_24060	COG0789	Transcriptional regulator
AWN88_24085	COG0517	IMP dehydrogenase activity
AWN88_24085	COG4175	Glycine betaine
AWN88_24090	COG4176	ABC-type proline glycine betaine transport system permease component
AWN88_24110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_24120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AWN88_24120	COG2169	Transcriptional regulator
AWN88_24130	COG2514	catechol 2,3-dioxygenase activity
AWN88_24140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AWN88_24145	COG1272	protein, Hemolysin III
AWN88_24155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AWN88_24165	COG2111	Na H antiporter
AWN88_24170	COG1006	Multisubunit Na H antiporter MnhC subunit
AWN88_24180	COG1863	multisubunit Na H antiporter MnhE subunit
AWN88_24185	COG2212	antiporter activity
AWN88_24190	COG1320	monovalent cation:proton antiporter activity
AWN88_24210	COG2166	iron-sulfur cluster assembly
AWN88_24220	COG2205	protein histidine kinase activity
AWN88_24275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AWN88_24280	COG2983	Belongs to the UPF0260 family
AWN88_24330	COG1621	beta-fructofuranosidase activity
AWN88_24335	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AWN88_24385	COG4695	Portal protein
AWN88_24470	COG0745	RESPONSE REGULATOR receiver
AWN88_24475	COG2205	protein histidine kinase activity
AWN88_24485	COG4235	cytochrome complex assembly
AWN88_24490	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AWN88_24495	COG1138	Cytochrome C-type biogenesis protein
AWN88_24500	COG3088	subunit of a heme lyase
AWN88_24505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AWN88_24510	COG0745	RESPONSE REGULATOR receiver
AWN88_24515	COG2205	protein histidine kinase activity
AWN88_24525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AWN88_24530	COG2205	protein histidine kinase activity
AWN88_24530	COG2202	Pas domain
AWN88_24540	COG0308	aminopeptidase N
AWN88_24545	COG0697	spore germination
AWN88_24560	COG0443	Heat shock 70 kDa protein
AWN88_24570	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_24595	COG1733	regulation of RNA biosynthetic process
AWN88_24600	COG1968	undecaprenyl-diphosphatase activity
AWN88_24605	COG2239	Acts as a magnesium transporter
AWN88_24610	COG2814	Major facilitator Superfamily
AWN88_24640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AWN88_24665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AWN88_24710	COG0741	lytic transglycosylase activity
AWN88_24715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AWN88_24720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AWN88_24725	COG0840	transmembrane signaling receptor activity
AWN88_24735	COG1758	RNA polymerase activity
AWN88_24755	COG0736	holo-[acyl-carrier-protein] synthase activity
AWN88_24760	COG0681	Belongs to the peptidase S26 family
AWN88_24765	COG0571	ribonuclease III activity
AWN88_24770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AWN88_24775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AWN88_24780	COG0784	Response regulator, receiver
AWN88_24785	COG1381	Involved in DNA repair and RecF pathway recombination
AWN88_24795	COG2226	methyltransferase
AWN88_24805	COG1418	mRNA catabolic process
AWN88_24815	COG0346	lactoylglutathione lyase activity
AWN88_24830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AWN88_24835	COG3443	Belongs to the bacterial solute-binding protein 9 family
AWN88_24840	COG0668	transmembrane transport
AWN88_24850	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AWN88_24880	COG1742	UPF0060 membrane protein
AWN88_24890	COG3706	GGDEF domain
AWN88_24890	COG0745	RESPONSE REGULATOR receiver
AWN88_24895	COG1183	phosphatidylcholine synthase activity
AWN88_24900	COG0688	phosphatidylethanolamine metabolic process
AWN88_24905	COG5265	(ABC) transporter
AWN88_24945	COG2852	Protein conserved in bacteria
AWN88_24950	COG0215	cysteine-tRNA ligase activity
AWN88_24955	COG4221	oxidoreductase activity
AWN88_24960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AWN88_24965	COG1286	toxin biosynthetic process
AWN88_24985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AWN88_24995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AWN88_25005	COG0305	Participates in initiation and elongation during chromosome replication
AWN88_25025	COG0359	binds to the 23S rRNA
AWN88_25035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AWN88_25040	COG0360	Binds together with S18 to 16S ribosomal RNA
AWN88_25045	COG0667	Aldo Keto reductase
AWN88_25050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AWN88_25060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AWN88_25065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AWN88_25070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AWN88_25075	COG1561	YicC-like family, N-terminal region
AWN88_25080	COG0194	GDP metabolic process
AWN88_25095	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AWN88_25100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AWN88_25110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AWN88_25125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AWN88_25145	COG4251	negative regulation of phosphorylation
AWN88_25145	COG3706	GGDEF domain
AWN88_25145	COG5001	Diguanylate cyclase
AWN88_25145	COG2203	Gaf domain
AWN88_25150	COG3300	MHYT domain
AWN88_25150	COG5001	Diguanylate cyclase
AWN88_25155	COG4191	Histidine kinase
AWN88_25170	COG0488	(ABC) transporter
AWN88_25175	COG3706	GGDEF domain
AWN88_25185	COG0105	UTP biosynthetic process
AWN88_25205	COG0314	molybdopterin synthase activity
AWN88_25215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AWN88_25220	COG0322	excinuclease ABC activity
AWN88_25225	COG1028	Short-chain dehydrogenase reductase Sdr
AWN88_25235	COG0625	glutathione transferase activity
AWN88_25250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AWN88_25255	COG0243	molybdopterin cofactor binding
AWN88_25275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AWN88_25280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AWN88_25285	COG0628	permease
AWN88_25295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AWN88_25300	COG0248	Ppx GppA phosphatase
AWN88_25325	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
AWN88_25330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AWN88_25335	COG0477	Major facilitator Superfamily
AWN88_25340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AWN88_25350	COG4452	Inner membrane protein CreD
AWN88_25360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AWN88_25370	COG2336	PFAM SpoVT AbrB
AWN88_25375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AWN88_25385	COG0113	porphobilinogen synthase activity
AWN88_25410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AWN88_25415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AWN88_25420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWN88_25420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AWN88_25430	COG1280	lysine exporter protein (LysE YggA)
AWN88_25435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AWN88_25440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AWN88_25445	COG2814	Major facilitator Superfamily
AWN88_25450	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AWN88_25470	COG0416	fatty acid biosynthetic process
AWN88_25475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AWN88_25480	COG0776	regulation of translation