locus-tag	class	description
FY146_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY146_00010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY146_00015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FY146_00020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FY146_00025	COG1420	regulation of RNA biosynthetic process
FY146_00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FY146_00035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_00040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FY146_00050	COG1137	ATPase activity
FY146_00055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FY146_00065	COG0616	signal peptide processing
FY146_00070	COG0776	regulation of translation
FY146_00080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FY146_00085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY146_00090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FY146_00105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FY146_00110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FY146_00115	COG0728	peptidoglycan biosynthetic process
FY146_00125	COG0180	Tryptophanyl-tRNA synthetase
FY146_00135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FY146_00140	COG1214	PFAM Peptidase M22, glycoprotease
FY146_00160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY146_00165	COG1702	phosphate starvation-inducible protein PhoH
FY146_00170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FY146_00180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FY146_00185	COG1396	sequence-specific DNA binding
FY146_00190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FY146_00195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FY146_00200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_00210	COG0242	peptide deformylase activity
FY146_00215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FY146_00220	COG0101	tRNA pseudouridine synthase activity
FY146_00230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_00235	COG2171	N-acyltransferase activity
FY146_00245	COG0840	transmembrane signaling receptor activity
FY146_00250	COG1957	nucleoside hydrolase
FY146_00255	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_00280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FY146_00290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FY146_00295	COG0706	membrane insertase activity
FY146_00300	COG0594	ribonuclease P activity
FY146_00305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FY146_00310	COG0840	transmembrane signaling receptor activity
FY146_00325	COG2226	methyltransferase
FY146_00330	COG3842	ATPase activity
FY146_00335	COG1175	transmembrane transport
FY146_00340	COG0395	ABC-type sugar transport system, permease component
FY146_00355	COG0427	acetyl-CoA hydrolase
FY146_00365	COG3938	Belongs to the proline racemase family
FY146_00370	COG0418	dihydroorotase activity
FY146_00375	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FY146_00395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY146_00400	COG0166	Belongs to the GPI family
FY146_00405	COG0318	PFAM AMP-dependent synthetase and ligase
FY146_00410	COG3842	ATPase activity
FY146_00415	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_00420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_00425	COG4774	siderophore transport
FY146_00470	COG2326	polyphosphate kinase activity
FY146_00475	COG5002	protein histidine kinase activity
FY146_00480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FY146_00485	COG0573	inorganic phosphate transmembrane transporter activity
FY146_00495	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FY146_00500	COG0704	Plays a role in the regulation of phosphate uptake
FY146_00505	COG0745	RESPONSE REGULATOR receiver
FY146_00515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FY146_00520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FY146_00530	COG2967	ApaG domain
FY146_00545	COG0717	Belongs to the dCTP deaminase family
FY146_00555	COG0582	viral genome integration into host DNA
FY146_00580	COG0419	ATPase involved in DNA repair
FY146_00600	COG1396	sequence-specific DNA binding
FY146_00640	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FY146_00645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FY146_00695	COG0167	dihydroorotate dehydrogenase activity
FY146_00730	COG1959	2 iron, 2 sulfur cluster binding
FY146_00735	COG1201	RNA secondary structure unwinding
FY146_00765	COG1960	acyl-CoA dehydrogenase activity
FY146_00770	COG0183	Belongs to the thiolase family
FY146_00780	COG1024	Enoyl-CoA hydratase
FY146_00780	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY146_00805	COG1320	monovalent cation:proton antiporter activity
FY146_00810	COG2212	antiporter activity
FY146_00815	COG1863	multisubunit Na H antiporter MnhE subunit
FY146_00820	COG0651	ATP synthesis coupled electron transport
FY146_00825	COG1006	Multisubunit Na H antiporter MnhC subunit
FY146_00830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY146_00830	COG2111	Na H antiporter
FY146_00840	COG0840	transmembrane signaling receptor activity
FY146_00850	COG0745	RESPONSE REGULATOR receiver
FY146_00855	COG0643	Histidine kinase
FY146_00855	COG2198	Histidine kinase
FY146_00860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FY146_00865	COG2201	protein-glutamate methylesterase activity
FY146_00870	COG0745	RESPONSE REGULATOR receiver
FY146_00875	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
FY146_00885	COG1766	The M ring may be actively involved in energy transduction
FY146_00890	COG2771	luxR family
FY146_00900	COG0840	transmembrane signaling receptor activity
FY146_00900	COG2972	Histidine kinase
FY146_00905	COG2205	protein histidine kinase activity
FY146_00905	COG0784	Response regulator, receiver
FY146_00905	COG2198	Histidine kinase
FY146_00910	COG1970	mechanosensitive ion channel activity
FY146_00915	COG0436	Aminotransferase
FY146_00930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FY146_00935	COG0424	maF-like protein
FY146_00940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FY146_00950	COG5328	Belongs to the UPF0262 family
FY146_00955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FY146_00965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FY146_01100	COG3728	DNA packaging
FY146_01100	COG5484	DNA packaging
FY146_01150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY146_01235	COG0582	viral genome integration into host DNA
FY146_01245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FY146_01255	COG1338	Plays a role in the flagellum-specific transport system
FY146_01265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FY146_01275	COG1706	bacterial-type flagellum-dependent cell motility
FY146_01280	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FY146_01285	COG4786	Flagellar basal body rod
FY146_01290	COG1677	Flagellar hook-basal body complex protein FliE
FY146_01295	COG1558	bacterial-type flagellum-dependent cell motility
FY146_01300	COG1815	bacterial-type flagellum-dependent cell motility
FY146_01310	COG1157	protein secretion by the type III secretion system
FY146_01315	COG4786	Flagellar basal body rod
FY146_01325	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FY146_01330	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_01335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_01340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FY146_01345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY146_01365	COG1360	Flagellar Motor Protein
FY146_01410	COG5443	negative regulation of bacterial-type flagellum assembly
FY146_01415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FY146_01425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FY146_01465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FY146_01470	COG1609	Transcriptional regulator
FY146_01475	COG1653	transport
FY146_01480	COG1175	transmembrane transport
FY146_01485	COG0395	ABC-type sugar transport system, permease component
FY146_01490	COG0366	Alpha amylase catalytic
FY146_01495	COG3842	ATPase activity
FY146_01510	COG0129	dihydroxy-acid dehydratase activity
FY146_01515	COG0363	glucosamine-6-phosphate deaminase activity
FY146_01520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FY146_01525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_01535	COG2081	HI0933 family
FY146_01555	COG2224	Isocitrate lyase
FY146_01570	COG3842	ATPase activity
FY146_01575	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_01580	COG1177	transmembrane transport
FY146_01595	COG2205	protein histidine kinase activity
FY146_01605	COG0248	Ppx GppA phosphatase
FY146_01610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FY146_01615	COG0477	Major facilitator Superfamily
FY146_01645	COG0521	Mo-molybdopterin cofactor biosynthetic process
FY146_01650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FY146_01660	COG0142	geranyltranstransferase activity
FY146_01685	COG0752	glycyl-tRNA synthetase alpha subunit
FY146_01695	COG1704	LemA family
FY146_01700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FY146_01710	COG0751	glycine-tRNA ligase activity
FY146_01715	COG1683	Conserved Protein
FY146_01720	COG0840	transmembrane signaling receptor activity
FY146_01730	COG0151	Belongs to the GarS family
FY146_01735	COG2183	response to ionizing radiation
FY146_01740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_01765	COG0583	DNA-binding transcription factor activity
FY146_01785	COG0306	phosphate transporter
FY146_01795	COG0561	phosphatase activity
FY146_01800	COG0438	transferase activity, transferring glycosyl groups
FY146_01805	COG2186	Transcriptional regulator
FY146_01815	COG0583	DNA-binding transcription factor activity
FY146_01820	COG0277	FAD linked oxidase domain protein
FY146_01825	COG0277	FAD linked oxidase domain protein
FY146_01830	COG0247	lactate metabolic process
FY146_01840	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_01845	COG2818	Glycosylase
FY146_01855	COG2855	membrane
FY146_01860	COG0583	DNA-binding transcription factor activity
FY146_01890	COG0124	histidyl-tRNA synthetase
FY146_01900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FY146_01905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FY146_01910	COG2259	Doxx family
FY146_01920	COG0459	protein refolding
FY146_01925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FY146_01935	COG0196	riboflavin kinase activity
FY146_01940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FY146_01950	COG0590	tRNA wobble adenosine to inosine editing
FY146_01955	COG1187	pseudouridine synthase activity
FY146_01960	COG0742	ribosomal rna small subunit methyltransferase
FY146_01965	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_01975	COG0312	modulator of DNA gyrase
FY146_01980	COG0483	inositol monophosphate 1-phosphatase activity
FY146_01990	COG1519	Transferase
FY146_02000	COG1663	tetraacyldisaccharide 4'-kinase activity
FY146_02010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FY146_02015	COG0745	RESPONSE REGULATOR receiver
FY146_02020	COG3300	MHYT domain
FY146_02020	COG5001	Diguanylate cyclase
FY146_02025	COG3386	PFAM SMP-30 Gluconolaconase
FY146_02030	COG0800	Aldolase
FY146_02035	COG3734	2-keto-3-deoxy-galactonokinase
FY146_02040	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_02045	COG1414	Transcriptional regulator
FY146_02050	COG2197	response regulator
FY146_02065	COG0598	Magnesium transport protein CorA
FY146_02070	COG3158	transport of potassium into the cell
FY146_02085	COG0356	it plays a direct role in the translocation of protons across the membrane
FY146_02095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY146_02100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FY146_02115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FY146_02135	COG0009	L-threonylcarbamoyladenylate synthase
FY146_02145	COG4638	Rieske (2fe-2S)
FY146_02170	COG1960	acyl-CoA dehydrogenase activity
FY146_02185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FY146_02190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FY146_02195	COG0840	transmembrane signaling receptor activity
FY146_02205	COG1522	sequence-specific DNA binding
FY146_02230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FY146_02235	COG1741	Belongs to the pirin family
FY146_02240	COG1722	exodeoxyribonuclease VII activity
FY146_02245	COG0123	including yeast histone deacetylase and acetoin utilization protein
FY146_02250	COG1268	BioY protein
FY146_02255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FY146_02260	COG1122	ATPase activity
FY146_02265	COG3214	Protein conserved in bacteria
FY146_02270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_02270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_02275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FY146_02295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY146_02310	COG0259	pyridoxamine-phosphate oxidase activity
FY146_02340	COG0312	modulator of DNA gyrase
FY146_02355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_02360	COG0109	protoheme IX farnesyltransferase activity
FY146_02365	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FY146_02380	COG3346	SURF1 family
FY146_02385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FY146_02390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FY146_02395	COG0328	RNA-DNA hybrid ribonuclease activity
FY146_02405	COG0678	peroxiredoxin activity
FY146_02405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FY146_02415	COG1678	Uncharacterized ACR, COG1678
FY146_02420	COG3237	CsbD-like
FY146_02430	COG5001	Diguanylate cyclase
FY146_02430	COG3300	MHYT domain
FY146_02435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FY146_02440	COG0612	Peptidase, M16
FY146_02465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY146_02470	COG1802	Transcriptional regulator
FY146_02485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FY146_02490	COG3609	addiction module antidote protein, CC2985 family
FY146_02495	COG3668	Plasmid stabilization system
FY146_02505	COG1194	a g-specific adenine glycosylase
FY146_02520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FY146_02525	COG1196	nuclear chromosome segregation
FY146_02530	COG2514	catechol 2,3-dioxygenase activity
FY146_02535	COG0574	Belongs to the PEP-utilizing enzyme family
FY146_02535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FY146_02545	COG1823	symporter activity
FY146_02570	COG0579	oxidoreductase
FY146_02585	COG2895	sulfate adenylyltransferase (ATP) activity
FY146_02590	COG0175	sulfate reduction
FY146_02595	COG0175	sulfate reduction
FY146_02600	COG1959	2 iron, 2 sulfur cluster binding
FY146_02605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FY146_02610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_02615	COG4208	sulfate ABC transporter
FY146_02620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_02630	COG2199	diguanylate cyclase activity
FY146_02630	COG2200	EAL domain
FY146_02630	COG2203	Gaf domain
FY146_02640	COG1309	transcriptional regulator
FY146_02645	COG1012	belongs to the aldehyde dehydrogenase family
FY146_02650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FY146_02680	COG0625	glutathione transferase activity
FY146_02690	COG0477	Major facilitator Superfamily
FY146_02700	COG3657	addiction module killer protein
FY146_02710	COG1793	dna ligase
FY146_02730	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_02735	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_02740	COG1846	Transcriptional regulator
FY146_02745	COG1764	response to oxidative stress
FY146_02760	COG0488	(ABC) transporter
FY146_02795	COG4221	oxidoreductase activity
FY146_02810	COG0433	COG0433 Predicted ATPase
FY146_02820	COG1733	regulation of RNA biosynthetic process
FY146_02825	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
FY146_02840	COG0656	L-ascorbic acid biosynthetic process
FY146_02845	COG3781	membrane
FY146_02850	COG2378	regulation of single-species biofilm formation
FY146_02860	COG4106	trans-aconitate 2-methyltransferase activity
FY146_02865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_02870	COG0840	transmembrane signaling receptor activity
FY146_02875	COG0583	DNA-binding transcription factor activity
FY146_02890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY146_02910	COG3909	cytochrome
FY146_02915	COG2010	Cytochrome c
FY146_02950	COG0789	Transcriptional regulator
FY146_02975	COG0517	IMP dehydrogenase activity
FY146_02975	COG4175	Glycine betaine
FY146_02980	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_03000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_03010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_03010	COG2169	Transcriptional regulator
FY146_03020	COG2514	catechol 2,3-dioxygenase activity
FY146_03040	COG1272	protein, Hemolysin III
FY146_03050	COG1280	lysine exporter protein (LysE YggA)
FY146_03055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY146_03060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FY146_03060	COG2111	Na H antiporter
FY146_03065	COG2111	Na H antiporter
FY146_03070	COG1006	Multisubunit Na H antiporter MnhC subunit
FY146_03075	COG0651	ATP synthesis coupled electron transport
FY146_03080	COG1863	multisubunit Na H antiporter MnhE subunit
FY146_03085	COG2212	antiporter activity
FY146_03090	COG1320	monovalent cation:proton antiporter activity
FY146_03095	COG4957	zinc ion binding
FY146_03110	COG2166	iron-sulfur cluster assembly
FY146_03120	COG2205	protein histidine kinase activity
FY146_03165	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_03170	COG2983	Belongs to the UPF0260 family
FY146_03185	COG2217	Heavy metal translocating P-type atpase
FY146_03215	COG2814	Major facilitator Superfamily
FY146_03220	COG1621	beta-fructofuranosidase activity
FY146_03225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FY146_03275	COG4695	Portal protein
FY146_03380	COG4235	cytochrome complex assembly
FY146_03385	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FY146_03390	COG1138	Cytochrome C-type biogenesis protein
FY146_03395	COG3088	subunit of a heme lyase
FY146_03400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_03405	COG0745	RESPONSE REGULATOR receiver
FY146_03410	COG2205	protein histidine kinase activity
FY146_03415	COG3011	Protein conserved in bacteria
FY146_03420	COG3713	MltA-interacting MipA family protein
FY146_03425	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FY146_03430	COG2205	protein histidine kinase activity
FY146_03430	COG2202	Pas domain
FY146_03440	COG0308	aminopeptidase N
FY146_03445	COG0697	spore germination
FY146_03460	COG0443	Heat shock 70 kDa protein
FY146_03495	COG0604	alcohol dehydrogenase
FY146_03500	COG1733	regulation of RNA biosynthetic process
FY146_03505	COG1968	undecaprenyl-diphosphatase activity
FY146_03510	COG2239	Acts as a magnesium transporter
FY146_03515	COG2814	Major facilitator Superfamily
FY146_03540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FY146_03565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY146_03605	COG0741	lytic transglycosylase activity
FY146_03610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_03615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FY146_03620	COG0840	transmembrane signaling receptor activity
FY146_03630	COG1758	RNA polymerase activity
FY146_03650	COG0736	holo-[acyl-carrier-protein] synthase activity
FY146_03655	COG0681	Belongs to the peptidase S26 family
FY146_03660	COG0571	ribonuclease III activity
FY146_03665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FY146_03675	COG0784	Response regulator, receiver
FY146_03680	COG1381	Involved in DNA repair and RecF pathway recombination
FY146_03690	COG2226	methyltransferase
FY146_03700	COG1418	mRNA catabolic process
FY146_03710	COG0346	lactoylglutathione lyase activity
FY146_03725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_03730	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY146_03735	COG0668	transmembrane transport
FY146_03745	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FY146_03775	COG1742	UPF0060 membrane protein
FY146_03790	COG1183	phosphatidylcholine synthase activity
FY146_03795	COG0688	phosphatidylethanolamine metabolic process
FY146_03800	COG5265	(ABC) transporter
FY146_03840	COG2852	Protein conserved in bacteria
FY146_03845	COG0215	cysteine-tRNA ligase activity
FY146_03850	COG4221	oxidoreductase activity
FY146_03855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FY146_03860	COG1286	toxin biosynthetic process
FY146_03875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY146_03885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FY146_03895	COG0305	Participates in initiation and elongation during chromosome replication
FY146_03915	COG0359	binds to the 23S rRNA
FY146_03925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FY146_03930	COG0360	Binds together with S18 to 16S ribosomal RNA
FY146_03940	COG0667	Aldo Keto reductase
FY146_03945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FY146_03955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_03960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_03970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FY146_03975	COG1561	YicC-like family, N-terminal region
FY146_03980	COG0194	GDP metabolic process
FY146_03995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FY146_04000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_04010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FY146_04025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY146_04045	COG5001	Diguanylate cyclase
FY146_04045	COG3706	GGDEF domain
FY146_04045	COG2203	Gaf domain
FY146_04045	COG4251	negative regulation of phosphorylation
FY146_04050	COG3300	MHYT domain
FY146_04050	COG5001	Diguanylate cyclase
FY146_04055	COG4191	Histidine kinase
FY146_04060	COG4566	intracellular signal transduction
FY146_04070	COG0488	(ABC) transporter
FY146_04075	COG3706	GGDEF domain
FY146_04085	COG0105	UTP biosynthetic process
FY146_04105	COG0314	molybdopterin synthase activity
FY146_04115	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FY146_04120	COG0322	excinuclease ABC activity
FY146_04125	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_04150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FY146_04155	COG0243	molybdopterin cofactor binding
FY146_04170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FY146_04175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FY146_04180	COG2226	methyltransferase
FY146_04185	COG0628	permease
FY146_04195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FY146_04200	COG0248	Ppx GppA phosphatase
FY146_04225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FY146_04235	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FY146_04240	COG0477	Major facilitator Superfamily
FY146_04245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FY146_04255	COG0840	transmembrane signaling receptor activity
FY146_04260	COG0659	secondary active sulfate transmembrane transporter activity
FY146_04270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY146_04275	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FY146_04285	COG0113	porphobilinogen synthase activity
FY146_04305	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY146_04310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FY146_04315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY146_04315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FY146_04325	COG1280	lysine exporter protein (LysE YggA)
FY146_04330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FY146_04335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY146_04340	COG2814	Major facilitator Superfamily
FY146_04345	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FY146_04365	COG0416	fatty acid biosynthetic process
FY146_04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY146_04375	COG0776	regulation of translation
FY146_04410	COG0601	transmembrane transport
FY146_04415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_04420	COG0444	Belongs to the ABC transporter superfamily
FY146_04430	COG0747	negative chemotaxis
FY146_04440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FY146_04445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FY146_04460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY146_04465	COG0583	DNA-binding transcription factor activity
FY146_04470	COG0737	Belongs to the 5'-nucleotidase family
FY146_04490	COG2897	thiosulfate sulfurtransferase activity
FY146_04505	COG0415	Belongs to the DNA photolyase family
FY146_04515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_04545	COG3932	Exopolysaccharide synthesis, ExoD
FY146_04550	COG1238	metal cluster binding
FY146_04625	COG1612	heme a metabolic process
FY146_04635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FY146_04640	COG0010	Belongs to the arginase family
FY146_04645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FY146_04650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FY146_04660	COG1832	CoA-binding protein
FY146_04690	COG2124	cytochrome p450
FY146_04695	COG2199	diguanylate cyclase activity
FY146_04700	COG0740	serine-type endopeptidase activity
FY146_04705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FY146_04710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FY146_04720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_04745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_04750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_04755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_04765	COG0649	NAD binding
FY146_04775	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FY146_04780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FY146_04790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FY146_04795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FY146_04805	COG0713	ATP synthesis coupled electron transport
FY146_04820	COG1007	ATP synthesis coupled electron transport
FY146_04825	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FY146_04825	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FY146_04840	COG0442	prolyl-tRNA aminoacylation
FY146_04850	COG1136	(ABC) transporter
FY146_04865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY146_04885	COG0784	Response regulator, receiver
FY146_04895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FY146_04900	COG0477	Major facilitator Superfamily
FY146_04915	COG0557	exoribonuclease II activity
FY146_04920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FY146_04930	COG0758	DNA mediated transformation
FY146_04935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FY146_04945	COG0540	Belongs to the ATCase OTCase family
FY146_04960	COG1960	acyl-CoA dehydrogenase activity
FY146_04965	COG0456	acetyltransferase
FY146_04985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FY146_04990	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_04995	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FY146_05000	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY146_05005	COG0154	amidase activity
FY146_05010	COG0456	acetyltransferase
FY146_05015	COG3811	Belongs to the UPF0386 family
FY146_05030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FY146_05060	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FY146_05065	COG0439	Biotin carboxylase
FY146_05070	COG0511	ligase activity, forming carbon-carbon bonds
FY146_05075	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY146_05085	COG0436	Aminotransferase
FY146_05105	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_05110	COG1530	ribonuclease E activity
FY146_05120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_05140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FY146_05145	COG0384	phenazine biosynthesis protein PhzF
FY146_05165	COG0633	Ferredoxin
FY146_05180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FY146_05185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FY146_05195	COG3768	UPF0283 membrane protein
FY146_05200	COG3106	COG3106 Predicted ATPase
FY146_05230	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY146_05265	COG0537	adenosine 5'-monophosphoramidase activity
FY146_05290	COG0052	Belongs to the universal ribosomal protein uS2 family
FY146_05295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FY146_05300	COG0528	UMP kinase activity
FY146_05305	COG0233	cytoplasmic translational termination
FY146_05310	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FY146_05320	COG0750	zinc metalloprotease
FY146_05325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY146_05330	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_05335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_05340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_05345	COG3494	Protein of unknown function (DUF1009)
FY146_05350	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FY146_05355	COG2186	Transcriptional regulator
FY146_05365	COG0765	amino acid transport
FY146_05370	COG0765	amino acid transport
FY146_05380	COG0372	Belongs to the citrate synthase family
FY146_05395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FY146_05420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FY146_05425	COG1459	type II secretion system
FY146_05480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FY146_05485	COG0148	phosphopyruvate hydratase activity
FY146_05495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FY146_05500	COG0022	dehydrogenase e1 component
FY146_05500	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_05505	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FY146_05525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FY146_05530	COG0697	spore germination
FY146_05545	COG2867	negative regulation of translational initiation
FY146_05550	COG1546	Belongs to the CinA family
FY146_05555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FY146_05555	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FY146_05565	COG3852	Histidine kinase
FY146_05570	COG2204	response regulator
FY146_05575	COG5000	phosphorelay sensor kinase activity
FY146_05580	COG2204	response regulator
FY146_05585	COG0569	domain protein
FY146_05590	COG1923	regulation of RNA biosynthetic process
FY146_05595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FY146_05600	COG3956	TIGRFAM MazG family protein
FY146_05610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY146_05610	COG1648	precorrin-2 dehydrogenase activity
FY146_05650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY146_05650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FY146_05655	COG0509	glycine decarboxylation via glycine cleavage system
FY146_05660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_05685	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FY146_05690	COG0564	pseudouridine synthase activity
FY146_05710	COG0251	oxidation-reduction process
FY146_05715	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FY146_05725	COG1671	Belongs to the UPF0178 family
FY146_05740	COG0450	alkyl hydroperoxide reductase
FY146_05745	COG0625	glutathione transferase activity
FY146_05755	COG2801	Transposase and inactivated derivatives
FY146_05760	COG0431	NADPH-dependent FMN reductase
FY146_05770	COG0798	PFAM Bile acid sodium symporter
FY146_05775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY146_05790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FY146_05790	COG0321	lipoyl(octanoyl) transferase activity
FY146_05795	COG0084	hydrolase, TatD family'
FY146_05800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_05810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FY146_05860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FY146_05865	COG2095	MarC family integral membrane protein
FY146_05870	COG0617	tRNA 3'-terminal CCA addition
FY146_05870	COG0517	IMP dehydrogenase activity
FY146_05870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FY146_05880	COG0629	single-stranded DNA binding
FY146_05885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FY146_05895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FY146_05915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_05920	COG1121	(ABC) transporter
FY146_05940	COG0667	Aldo Keto reductase
FY146_05950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FY146_06035	COG2239	Acts as a magnesium transporter
FY146_06040	COG0243	molybdopterin cofactor binding
FY146_06050	COG0242	peptide deformylase activity
FY146_06060	COG2202	Pas domain
FY146_06060	COG2205	protein histidine kinase activity
FY146_06070	COG0321	lipoyl(octanoyl) transferase activity
FY146_06075	COG1064	alcohol dehydrogenase
FY146_06105	COG1862	Preprotein translocase
FY146_06125	COG2124	cytochrome p450
FY146_06140	COG0596	Alpha beta hydrolase
FY146_06150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_06155	COG0626	cystathionine gamma-synthase activity
FY146_06160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_06165	COG4597	amino acid ABC transporter
FY146_06170	COG0765	amino acid transport
FY146_06175	COG1126	abc transporter atp-binding protein
FY146_06190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FY146_06205	COG0436	Aminotransferase
FY146_06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_06245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_06250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_06255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FY146_06270	COG3243	poly(R)-hydroxyalkanoic acid synthase
FY146_06275	COG1489	DNA binding
FY146_06280	COG0024	Methionine aminopeptidase
FY146_06285	COG2003	Belongs to the UPF0758 family
FY146_06300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FY146_06325	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FY146_06330	COG0546	phosphoglycolate phosphatase activity
FY146_06340	COG0114	fumarate hydratase activity
FY146_06350	COG0504	CTP synthase activity
FY146_06360	COG0149	triose-phosphate isomerase activity
FY146_06370	COG0187	DNA topoisomerase II activity
FY146_06380	COG0740	serine-type endopeptidase activity
FY146_06390	COG0640	Transcriptional regulator
FY146_06395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_06400	COG0745	RESPONSE REGULATOR receiver
FY146_06415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FY146_06415	COG3264	Mechanosensitive ion channel
FY146_06480	COG1127	ABC transporter
FY146_06485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FY146_06490	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_06500	COG0281	malic enzyme
FY146_06500	COG0280	phosphate acetyltransferase
FY146_06510	COG0778	Nitroreductase
FY146_06515	COG0823	Involved in the tonB-independent uptake of proteins
FY146_06530	COG1368	sulfuric ester hydrolase activity
FY146_06555	COG0544	peptidyl-prolyl cis-trans isomerase activity
FY146_06575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FY146_06595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FY146_06610	COG0318	PFAM AMP-dependent synthetase and ligase
FY146_06620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY146_06620	COG0512	Glutamine amidotransferase of anthranilate synthase
FY146_06625	COG0343	queuine tRNA-ribosyltransferase activity
FY146_06630	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FY146_06645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FY146_06660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_06665	COG0134	indole-3-glycerol-phosphate synthase activity
FY146_06670	COG0315	cyclic pyranopterin monophosphate synthase activity
FY146_06675	COG0303	'Molybdopterin
FY146_06680	COG3706	GGDEF domain
FY146_06690	COG0475	glutathione-regulated potassium exporter activity
FY146_06690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FY146_06700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FY146_06710	COG2814	Major facilitator Superfamily
FY146_06715	COG0746	molybdenum cofactor guanylyltransferase activity
FY146_06720	COG1763	Mo-molybdopterin cofactor biosynthetic process
FY146_06725	COG0739	heme binding
FY146_06730	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY146_06735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FY146_06740	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY146_06745	COG0805	protein transport
FY146_06750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY146_06755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FY146_06760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY146_06765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FY146_06770	COG1472	Belongs to the glycosyl hydrolase 3 family
FY146_06780	COG0018	arginyl-trna synthetase
FY146_06785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FY146_06810	COG0525	valine-tRNA ligase activity
FY146_06820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FY146_06960	COG1525	nuclease
FY146_07035	COG3567	Phage-associated protein, HI1409 family
FY146_07085	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FY146_07270	COG0655	NAD(P)H dehydrogenase (quinone) activity
FY146_07275	COG1058	Belongs to the CinA family
FY146_07275	COG1546	Belongs to the CinA family
FY146_07280	COG0589	response to stress
FY146_07285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FY146_07295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FY146_07305	COG0640	Transcriptional regulator
FY146_07310	COG1914	H( )-stimulated, divalent metal cation uptake system
FY146_07320	COG1132	(ABC) transporter
FY146_07325	COG0628	permease
FY146_07360	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FY146_07370	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FY146_07380	COG0302	gtp cyclohydrolase
FY146_07385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FY146_07390	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_07400	COG0516	GMP reductase activity
FY146_07400	COG0517	IMP dehydrogenase activity
FY146_07435	COG1760	l-serine dehydratase
FY146_07475	COG0583	DNA-binding transcription factor activity
FY146_07490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FY146_07490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FY146_07500	COG0347	Belongs to the P(II) protein family
FY146_07505	COG0174	glutamine synthetase
FY146_07535	COG0697	spore germination
FY146_07545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FY146_07555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FY146_07585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY146_07595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FY146_07600	COG2186	Transcriptional regulator
FY146_07610	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_07615	COG4603	Belongs to the binding-protein-dependent transport system permease family
FY146_07620	COG3845	ABC transporter
FY146_07625	COG1183	phosphatidylcholine synthase activity
FY146_07630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_07635	COG0679	Auxin Efflux Carrier
FY146_07640	COG0785	Cytochrome C biogenesis protein
FY146_07660	COG1278	Cold shock
FY146_07710	COG1136	(ABC) transporter
FY146_07710	COG0577	efflux transmembrane transporter activity
FY146_07715	COG0577	efflux transmembrane transporter activity
FY146_07715	COG1136	(ABC) transporter
FY146_07740	COG2151	metal-sulfur cluster biosynthetic enzyme
FY146_07745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FY146_07750	COG0719	Fe-S assembly protein
FY146_07755	COG0396	ATPase activity
FY146_07760	COG0719	Fe-S assembly protein
FY146_07765	COG1104	cysteine desulfurase activity
FY146_07770	COG2945	thiolester hydrolase activity
FY146_07775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FY146_07780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY146_07790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FY146_07795	COG2833	Protein of unknown function (DUF455)
FY146_07800	COG0739	heme binding
FY146_07805	COG0513	Belongs to the DEAD box helicase family
FY146_07830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY146_07840	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY146_07845	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY146_07850	COG0047	phosphoribosylformylglycinamidine synthase activity
FY146_07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_07870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FY146_07890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FY146_07895	COG2814	Major facilitator Superfamily
FY146_07900	COG0483	inositol monophosphate 1-phosphatase activity
FY146_07905	COG0483	inositol monophosphate 1-phosphatase activity
FY146_07910	COG0037	tRNA processing
FY146_07915	COG2066	Belongs to the glutaminase family
FY146_07920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FY146_07925	COG0861	Integral membrane protein TerC family
FY146_07940	COG1280	lysine exporter protein (LysE YggA)
FY146_07950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FY146_07955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FY146_07965	COG0538	isocitrate dehydrogenase activity
FY146_07975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FY146_07980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FY146_07985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_07990	COG2313	pseudouridylate synthase activity
FY146_08000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_08005	COG4215	(ABC) transporter
FY146_08015	COG5425	PFAM Usg family protein
FY146_08025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_08030	COG1522	sequence-specific DNA binding
FY146_08035	COG1573	uracil-dna glycosylase
FY146_08045	COG2205	protein histidine kinase activity
FY146_08045	COG2202	Pas domain
FY146_08050	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FY146_08055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FY146_08060	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FY146_08075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FY146_08080	COG0842	Transport permease protein
FY146_08085	COG1131	(ABC) transporter
FY146_08090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_08090	COG0730	response to heat
FY146_08110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FY146_08115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FY146_08135	COG0129	dihydroxy-acid dehydratase activity
FY146_08140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FY146_08145	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FY146_08155	COG3739	integral membrane protein
FY146_08160	COG0203	ribosomal protein L17
FY146_08165	COG0202	RNA polymerase activity
FY146_08170	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FY146_08175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FY146_08180	COG0563	adenylate kinase activity
FY146_08185	COG0201	protein transport
FY146_08190	COG0200	Binds to the 23S rRNA
FY146_08195	COG1841	ribosomal large subunit assembly
FY146_08200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FY146_08205	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FY146_08210	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FY146_08215	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FY146_08220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FY146_08225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FY146_08230	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FY146_08235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FY146_08240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FY146_08245	COG0255	Belongs to the universal ribosomal protein uL29 family
FY146_08250	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FY146_08255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FY146_08260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FY146_08265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FY146_08270	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FY146_08275	COG0089	rRNA binding
FY146_08280	COG0088	Forms part of the polypeptide exit tunnel
FY146_08285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FY146_08290	COG0051	transcription antitermination factor activity, RNA binding
FY146_08295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY146_08300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FY146_08305	COG0049	tRNA binding
FY146_08310	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FY146_08330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FY146_08335	COG0085	RNA polymerase activity
FY146_08340	COG0222	ribosome binding
FY146_08345	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FY146_08350	COG0081	regulation of translation
FY146_08355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FY146_08365	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FY146_08375	COG1086	Polysaccharide biosynthesis protein
FY146_08380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FY146_08385	COG0861	Integral membrane protein TerC family
FY146_08390	COG3895	Periplasmic Protein
FY146_08410	COG1132	(ABC) transporter
FY146_08415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_08435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FY146_08470	COG2205	protein histidine kinase activity
FY146_08470	COG2198	Histidine kinase
FY146_08470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_08470	COG0784	Response regulator, receiver
FY146_08475	COG0784	Response regulator, receiver
FY146_08480	COG2202	Pas domain
FY146_08480	COG3920	Histidine kinase
FY146_08485	COG0784	Response regulator, receiver
FY146_08490	COG4251	negative regulation of phosphorylation
FY146_08505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FY146_08510	COG1607	acyl-coa hydrolase
FY146_08530	COG2910	NAD(P)H-binding
FY146_08535	COG1733	regulation of RNA biosynthetic process
FY146_08550	COG0556	nucleotide-excision repair
FY146_08560	COG2382	esterase
FY146_08580	COG0484	heat shock protein binding
FY146_08600	COG3706	GGDEF domain
FY146_08620	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_08625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_08640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FY146_08650	COG2207	Transcriptional regulator
FY146_08655	COG1064	alcohol dehydrogenase
FY146_08660	COG1252	NADH dehydrogenase
FY146_08665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FY146_08670	COG2197	response regulator
FY146_08675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FY146_08710	COG0656	L-ascorbic acid biosynthetic process
FY146_08725	COG0440	acetolactate synthase activity
FY146_08730	COG0028	Belongs to the TPP enzyme family
FY146_08740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FY146_08745	COG0560	Phosphoserine phosphatase
FY146_08745	COG3830	Belongs to the UPF0237 family
FY146_08765	COG0330	HflC and HflK could
FY146_08770	COG0330	HflC and HflK could
FY146_08780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FY146_08815	COG0277	FAD linked oxidase domain protein
FY146_08820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_08860	COG1335	isochorismatase
FY146_08885	COG2264	protein methyltransferase activity
FY146_08890	COG1999	signal sequence binding
FY146_08900	COG0835	chemotaxis
FY146_08910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FY146_08915	COG0583	DNA-binding transcription factor activity
FY146_08925	COG1247	-acetyltransferase
FY146_08935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FY146_08940	COG0497	DNA recombination
FY146_08945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FY146_08955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_08960	COG0849	cell division
FY146_08965	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FY146_08970	COG1181	Belongs to the D-alanine--D-alanine ligase family
FY146_08975	COG0477	Major facilitator Superfamily
FY146_08980	COG5001	Diguanylate cyclase
FY146_08985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FY146_08990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FY146_08995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY146_09005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FY146_09010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FY146_09020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FY146_09035	COG0275	rRNA processing
FY146_09040	COG2001	Belongs to the MraZ family
FY146_09065	COG3023	N-Acetylmuramoyl-L-alanine amidase
FY146_09095	COG4106	trans-aconitate 2-methyltransferase activity
FY146_09115	COG2226	methyltransferase
FY146_09125	COG2267	carboxylic ester hydrolase activity
FY146_09130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FY146_09145	COG0251	oxidation-reduction process
FY146_09160	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_09165	COG2814	Major facilitator Superfamily
FY146_09195	COG1012	belongs to the aldehyde dehydrogenase family
FY146_09200	COG0174	glutamine synthetase
FY146_09205	COG0531	amino acid
FY146_09215	COG1737	Transcriptional regulator
FY146_09220	COG2182	Extracellular solute-binding protein
FY146_09235	COG3842	ATPase activity
FY146_09295	COG2968	Membrane
FY146_09305	COG0432	Pfam Uncharacterised protein family UPF0047
FY146_09320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY146_09325	COG0358	DNA primase activity
FY146_09345	COG0505	Belongs to the CarA family
FY146_09350	COG0534	Mate efflux family protein
FY146_09365	COG2321	neutral zinc metallopeptidase
FY146_09380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FY146_09390	COG3706	GGDEF domain
FY146_09405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY146_09415	COG1522	sequence-specific DNA binding
FY146_09420	COG0492	ferredoxin-NADP+ reductase activity
FY146_09425	COG0583	DNA-binding transcription factor activity
FY146_09435	COG1902	pentaerythritol trinitrate reductase activity
FY146_09460	COG0387	Pfam Sodium calcium exchanger
FY146_09465	COG0436	Aminotransferase
FY146_09470	COG2200	EAL domain
FY146_09470	COG2199	diguanylate cyclase activity
FY146_09485	COG1278	Cold shock
FY146_09490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_09500	COG1846	Transcriptional regulator
FY146_09505	COG0745	RESPONSE REGULATOR receiver
FY146_09515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_09535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FY146_09545	COG1496	oxidoreductase activity
FY146_09560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FY146_09570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FY146_09585	COG0840	transmembrane signaling receptor activity
FY146_09590	COG1012	belongs to the aldehyde dehydrogenase family
FY146_09595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FY146_09600	COG5001	Diguanylate cyclase
FY146_09600	COG3300	MHYT domain
FY146_09605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FY146_09610	COG5001	Diguanylate cyclase
FY146_09620	COG0193	aminoacyl-tRNA hydrolase activity
FY146_09630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FY146_09655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FY146_09665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FY146_09665	COG2857	Cytochrome c1
FY146_09685	COG1132	(ABC) transporter
FY146_09695	COG1132	(ABC) transporter
FY146_09705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FY146_09720	COG0408	coproporphyrinogen oxidase activity
FY146_09735	COG0617	tRNA 3'-terminal CCA addition
FY146_09750	COG0714	Associated with various cellular activities
FY146_09770	COG0454	-acetyltransferase
FY146_09785	COG0477	Major facilitator Superfamily
FY146_09795	COG0435	Glutathione S-transferase
FY146_09800	COG0494	nUDIX hydrolase
FY146_09810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY146_09815	COG3135	benzoate transporter
FY146_09840	COG0740	serine-type endopeptidase activity
FY146_09855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FY146_09860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FY146_09885	COG4175	Glycine betaine
FY146_09905	COG1435	thymidine kinase activity
FY146_09930	COG1629	transport
FY146_09930	COG4771	TonB-dependent receptor
FY146_09940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FY146_09940	COG0512	Glutamine amidotransferase of anthranilate synthase
FY146_09955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY146_09965	COG0366	Alpha amylase catalytic
FY146_09970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_09990	COG1160	GTP binding
FY146_10010	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FY146_10020	COG0024	Methionine aminopeptidase
FY146_10030	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_10050	COG0583	DNA-binding transcription factor activity
FY146_10065	COG0402	S-adenosylhomocysteine deaminase activity
FY146_10075	COG1304	FMN binding
FY146_10085	COG1309	transcriptional regulator
FY146_10090	COG1686	Belongs to the peptidase S11 family
FY146_10100	COG2351	hydroxyisourate hydrolase activity
FY146_10105	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FY146_10130	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_10140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_10140	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FY146_10150	COG0513	Belongs to the DEAD box helicase family
FY146_10160	COG2259	Doxx family
FY146_10165	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_10175	COG2308	Evidence 4 Homologs of previously reported genes of
FY146_10185	COG1305	Transglutaminase-like
FY146_10210	COG4214	carbohydrate transport
FY146_10220	COG4213	ABC transporter substrate-binding protein
FY146_10275	COG2948	multi-organism process
FY146_10285	COG3701	Conjugal transfer protein
FY146_10290	COG3846	protein secretion by the type IV secretion system
FY146_10305	COG3451	type IV secretory pathway VirB4
FY146_10320	COG4962	Type ii secretion system protein e
FY146_10345	COG0583	DNA-binding transcription factor activity
FY146_10355	COG1566	PFAM secretion protein HlyD family protein
FY146_10370	COG2207	Transcriptional regulator
FY146_10375	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_10385	COG0583	DNA-binding transcription factor activity
FY146_10395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FY146_10410	COG0583	DNA-binding transcription factor activity
FY146_10420	COG0741	lytic transglycosylase activity
FY146_10445	COG1192	Involved in chromosome partitioning
FY146_10480	COG2814	Major facilitator Superfamily
FY146_10490	COG5489	Protein of unknown function (DUF736)
FY146_10505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY146_10535	COG1204	response to ionizing radiation
FY146_10550	COG0514	ATP-dependent DNA helicase (RecQ)
FY146_10600	COG0583	DNA-binding transcription factor activity
FY146_10605	COG1902	pentaerythritol trinitrate reductase activity
FY146_10610	COG0583	DNA-binding transcription factor activity
FY146_10625	COG1335	isochorismatase
FY146_10630	COG0583	DNA-binding transcription factor activity
FY146_10635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_10645	COG4584	PFAM Integrase catalytic
FY146_10660	COG0840	transmembrane signaling receptor activity
FY146_10675	COG0646	methionine synthase
FY146_10675	COG1410	methionine synthase
FY146_10690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_10720	COG1215	transferase activity, transferring glycosyl groups
FY146_10750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY146_10765	COG2346	COG2346, Truncated hemoglobins
FY146_10785	COG1309	transcriptional regulator
FY146_10800	COG0494	nUDIX hydrolase
FY146_10810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_10815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_10845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FY146_10850	COG0830	nickel cation binding
FY146_10855	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FY146_10870	COG0804	urea catabolic process
FY146_10875	COG1442	glycosyl transferase family 8
FY146_10880	COG3755	Protein conserved in bacteria
FY146_10890	COG0832	Belongs to the urease beta subunit family
FY146_10895	COG3813	Protein conserved in bacteria
FY146_10900	COG0831	urea catabolic process
FY146_10905	COG0829	nickel cation binding
FY146_10935	COG0559	Belongs to the binding-protein-dependent transport system permease family
FY146_10950	COG0174	glutamine synthetase
FY146_10955	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_10960	COG5002	protein histidine kinase activity
FY146_10960	COG2198	Histidine kinase
FY146_10960	COG0784	Response regulator, receiver
FY146_10975	COG0726	polysaccharide deacetylase
FY146_11010	COG1218	3'(2'),5'-bisphosphate nucleotidase
FY146_11085	COG0564	pseudouridine synthase activity
FY146_11095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FY146_11105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FY146_11130	COG0346	lactoylglutathione lyase activity
FY146_11140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FY146_11150	COG2832	Protein of unknown function (DUF454)
FY146_11155	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FY146_11160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_11165	COG4558	Periplasmic binding protein
FY146_11175	COG3721	Heme iron utilization protein
FY146_11190	COG3655	Transcriptional regulator
FY146_11215	COG2205	protein histidine kinase activity
FY146_11255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_11260	COG4605	iron ion homeostasis
FY146_11265	COG4604	ABC transporter, ATP-binding protein
FY146_11270	COG0783	Belongs to the Dps family
FY146_11285	COG2972	Histidine kinase
FY146_11285	COG0840	transmembrane signaling receptor activity
FY146_11290	COG0656	L-ascorbic acid biosynthetic process
FY146_11295	COG2814	Major facilitator Superfamily
FY146_11305	COG0583	DNA-binding transcription factor activity
FY146_11310	COG0657	acetylesterase activity
FY146_11315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_11335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_11340	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FY146_11345	COG0288	reversible hydration of carbon dioxide
FY146_11355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FY146_11375	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FY146_11380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_11385	COG0778	Nitroreductase
FY146_11390	COG2267	carboxylic ester hydrolase activity
FY146_11395	COG0251	oxidation-reduction process
FY146_11400	COG1335	isochorismatase
FY146_11405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_11415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_11430	COG1175	transmembrane transport
FY146_11435	COG0395	ABC-type sugar transport system, permease component
FY146_11440	COG3842	ATPase activity
FY146_11445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_11455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_11470	COG4608	Belongs to the ABC transporter superfamily
FY146_11475	COG0444	Belongs to the ABC transporter superfamily
FY146_11480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_11485	COG0601	transmembrane transport
FY146_11540	COG2159	amidohydrolase
FY146_11545	COG1960	acyl-CoA dehydrogenase activity
FY146_11575	COG0745	RESPONSE REGULATOR receiver
FY146_11585	COG1902	pentaerythritol trinitrate reductase activity
FY146_11585	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_11590	COG3842	ATPase activity
FY146_11600	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_11605	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_11610	COG0745	RESPONSE REGULATOR receiver
FY146_11620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY146_11625	COG0583	DNA-binding transcription factor activity
FY146_11630	COG1278	Cold shock
FY146_11665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FY146_11670	COG1309	transcriptional regulator
FY146_11675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_11680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_11690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FY146_11695	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FY146_11715	COG0583	DNA-binding transcription factor activity
FY146_11720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_11725	COG0725	ABC transporter, periplasmic molybdate-binding protein
FY146_11730	COG4149	molybdate abc transporter
FY146_11735	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FY146_11750	COG2022	thiamine diphosphate biosynthetic process
FY146_11765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FY146_11775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_11785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FY146_11805	COG1132	(ABC) transporter
FY146_11810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FY146_11855	COG4166	transmembrane transport
FY146_11860	COG0601	transmembrane transport
FY146_11865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_11880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FY146_11885	COG3142	Participates in the control of copper homeostasis
FY146_11890	COG2814	Major facilitator Superfamily
FY146_11905	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_11910	COG1737	Transcriptional regulator
FY146_11920	COG3842	ATPase activity
FY146_11930	COG0395	ABC-type sugar transport system, permease component
FY146_11950	COG2188	Transcriptional regulator
FY146_11955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FY146_11960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FY146_11965	COG1940	carbohydrate kinase activity
FY146_11975	COG0671	phosphoesterase, PA-phosphatase related
FY146_11980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FY146_11985	COG0156	8-amino-7-oxononanoate synthase activity
FY146_11995	COG0729	surface antigen
FY146_12005	COG0835	chemotaxis
FY146_12015	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FY146_12020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FY146_12025	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FY146_12030	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FY146_12035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FY146_12040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FY146_12055	COG4974	Belongs to the 'phage' integrase family
FY146_12080	COG1280	lysine exporter protein (LysE YggA)
FY146_12090	COG0508	dehydrogenase complex catalyzes the overall conversion of
FY146_12095	COG0567	Dehydrogenase, E1 component
FY146_12100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FY146_12105	COG0045	succinate-CoA ligase (ADP-forming) activity
FY146_12110	COG0039	L-malate dehydrogenase activity
FY146_12115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FY146_12165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FY146_12170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FY146_12175	COG0181	hydroxymethylbilane synthase activity
FY146_12215	COG1872	DUF167
FY146_12220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FY146_12230	COG1217	gtp-binding protein TYPA
FY146_12235	COG0339	signal peptide processing
FY146_12240	COG1846	Transcriptional regulator
FY146_12250	COG0137	argininosuccinate synthase activity
FY146_12260	COG1280	lysine exporter protein (LysE YggA)
FY146_12265	COG1122	ATPase activity
FY146_12270	COG4120	Belongs to the binding-protein-dependent transport system permease family
FY146_12280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FY146_12295	COG2154	pterin-4-alpha-carbinolamine dehydratase
FY146_12300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FY146_12305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FY146_12315	COG4181	ATPase activity
FY146_12325	COG0670	Belongs to the BI1 family
FY146_12340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FY146_12345	COG4133	protoheme IX ABC transporter activity
FY146_12350	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY146_12355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FY146_12380	COG2917	probably involved in intracellular septation
FY146_12385	COG0552	protein localization to endoplasmic reticulum
FY146_12390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FY146_12395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FY146_12410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FY146_12415	COG0287	Prephenate dehydrogenase
FY146_12415	COG1605	Chorismate mutase
FY146_12420	COG0228	four-way junction DNA binding
FY146_12425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FY146_12430	COG0336	Belongs to the RNA methyltransferase TrmD family
FY146_12440	COG0335	large ribosomal subunit rRNA binding
FY146_12445	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY146_12450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_12465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FY146_12485	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FY146_12505	COG0488	(ABC) transporter
FY146_12515	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FY146_12525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FY146_12530	COG0142	geranyltranstransferase activity
FY146_12535	COG2885	chlorophyll binding
FY146_12540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FY146_12545	COG2223	nitrite transmembrane transporter activity
FY146_12550	COG1349	DNA-binding transcription factor activity
FY146_12555	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY146_12560	COG2197	response regulator
FY146_12565	COG1132	(ABC) transporter
FY146_12575	COG3459	Glycosyltransferase 36 associated
FY146_12580	COG1473	amidohydrolase
FY146_12585	COG0579	oxidoreductase
FY146_12595	COG0129	dihydroxy-acid dehydratase activity
FY146_12600	COG2084	Dehydrogenase
FY146_12605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_12610	COG0277	FAD linked oxidase domain protein
FY146_12615	COG2186	Transcriptional regulator
FY146_12625	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_12630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_12635	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_12640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY146_12650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FY146_12655	COG0495	leucyl-tRNA aminoacylation
FY146_12670	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY146_12675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FY146_12690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_12695	COG1946	Acyl-CoA thioesterase
FY146_12700	COG0347	Belongs to the P(II) protein family
FY146_12705	COG0004	ammonium transporteR
FY146_12710	COG1674	ftsk spoiiie
FY146_12715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FY146_12730	COG0745	RESPONSE REGULATOR receiver
FY146_12740	COG1329	Transcriptional regulator
FY146_12750	COG2270	Major facilitator Superfamily
FY146_12765	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_12780	COG0494	nUDIX hydrolase
FY146_12785	COG2861	carbohydrate metabolic process
FY146_12790	COG0793	Belongs to the peptidase S41A family
FY146_12800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FY146_12805	COG0799	negative regulation of ribosome biogenesis
FY146_12810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FY146_12815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FY146_12820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FY146_12825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FY146_12840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FY146_12845	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FY146_12870	COG0066	3-isopropylmalate dehydratase activity
FY146_12875	COG0473	3-isopropylmalate dehydrogenase activity
FY146_12880	COG1858	cytochrome C peroxidase
FY146_12885	COG1797	cobyrinic acid a,c-diamide synthase activity
FY146_12895	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FY146_12960	COG1492	cobalamin metabolic process
FY146_12975	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_12980	COG3254	rhamnose metabolic process
FY146_12985	COG0246	Mannitol dehydrogenase
FY146_12990	COG1063	alcohol dehydrogenase
FY146_13015	COG1129	ABC transporter
FY146_13020	COG2186	Transcriptional regulator
FY146_13025	COG2721	sulfolactate sulfo-lyase activity
FY146_13030	COG0138	bifunctional purine biosynthesis protein purh
FY146_13040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FY146_13040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FY146_13045	COG0501	Belongs to the peptidase M48B family
FY146_13065	COG0357	Ribosomal RNA small subunit methyltransferase G
FY146_13070	COG0445	tRNA wobble uridine modification
FY146_13075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FY146_13080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FY146_13085	COG1981	membrane
FY146_13090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FY146_13095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FY146_13100	COG0424	maF-like protein
FY146_13105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY146_13110	COG0237	dephospho-CoA kinase activity
FY146_13120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FY146_13125	COG3030	protein affecting phage T7 exclusion by the F plasmid
FY146_13135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FY146_13160	COG0179	Fumarylacetoacetate (FAA) hydrolase
FY146_13175	COG0135	phosphoribosylanthranilate isomerase activity
FY146_13180	COG0133	tryptophan synthase activity
FY146_13185	COG0159	tryptophan synthase activity
FY146_13190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FY146_13205	COG1074	ATP-dependent DNA helicase activity
FY146_13215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FY146_13220	COG0802	atpase or kinase
FY146_13225	COG2205	protein histidine kinase activity
FY146_13230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FY146_13235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_13240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FY146_13240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FY146_13245	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FY146_13250	COG0642	Histidine kinase
FY146_13255	COG0745	RESPONSE REGULATOR receiver
FY146_13260	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FY146_13270	COG1652	LysM domain
FY146_13275	COG1072	(Pantothenic acid kinase))
FY146_13280	COG0140	phosphoribosyl-ATP diphosphatase activity
FY146_13285	COG0107	imidazoleglycerol-phosphate synthase activity
FY146_13290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FY146_13295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FY146_13305	COG0131	Imidazoleglycerol-phosphate dehydratase
FY146_13310	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FY146_13315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FY146_13325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FY146_13340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
FY146_13350	COG1643	Atp-dependent helicase
FY146_13395	COG1940	carbohydrate kinase activity
FY146_13415	COG1072	(Pantothenic acid kinase))
FY146_13425	COG1780	Probably involved in ribonucleotide reductase function
FY146_13445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FY146_13475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_13485	COG2813	Specifically methylates the guanine in position
FY146_13490	COG1185	polyribonucleotide nucleotidyltransferase activity
FY146_13495	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FY146_13500	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FY146_13505	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FY146_13510	COG3064	Membrane
FY146_13510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FY146_13525	COG0779	Required for maturation of 30S ribosomal subunits
FY146_13530	COG2814	Major facilitator Superfamily
FY146_13540	COG2951	lytic endotransglycosylase activity
FY146_13545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FY146_13555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FY146_13560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FY146_13575	COG2816	NAD+ diphosphatase activity
FY146_13580	COG0077	Prephenate dehydratase
FY146_13580	COG1605	Chorismate mutase
FY146_13585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FY146_13590	COG3474	cytochrome
FY146_13600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FY146_13605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FY146_13610	COG1278	Cold shock
FY146_13615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_13625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY146_13625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FY146_13630	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FY146_13660	COG2900	Belongs to the SlyX family
FY146_13670	COG0484	heat shock protein binding
FY146_13675	COG0443	Heat shock 70 kDa protein
FY146_13690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FY146_13695	COG1744	ABC transporter substrate-binding protein PnrA-like
FY146_13700	COG3845	ABC transporter
FY146_13705	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_13710	COG1079	Belongs to the binding-protein-dependent transport system permease family
FY146_13715	COG0295	cytidine deaminase activity
FY146_13720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FY146_13725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FY146_13730	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FY146_13740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FY146_13745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FY146_13750	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FY146_13760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FY146_13765	COG1845	cytochrome c oxidase, subunit III
FY146_13770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_13775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY146_13780	COG0477	Major facilitator Superfamily
FY146_13785	COG0070	glutamate synthase
FY146_13785	COG0067	glutamate synthase
FY146_13785	COG0069	glutamate synthase activity
FY146_13790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FY146_13805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FY146_13815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FY146_13845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_13865	COG0848	biopolymer transport protein
FY146_13875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_13890	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_13895	COG3454	Phosphonate metabolism
FY146_13900	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FY146_13905	COG3639	organic phosphonate transmembrane transporter activity
FY146_13910	COG3639	organic phosphonate transmembrane transporter activity
FY146_13920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FY146_13930	COG4778	phosphonate C-P lyase system protein PhnL
FY146_13935	COG4107	phosphonate C-P lyase system protein PhnK
FY146_13940	COG3627	carbon phosphorus lyase activity
FY146_13945	COG3626	phosphonate metabolism
FY146_13950	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FY146_13955	COG3624	Phosphonate C-P lyase system protein PhnG
FY146_13960	COG2188	Transcriptional regulator
FY146_13965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FY146_13970	COG0837	glucose binding
FY146_13975	COG1803	Methylglyoxal synthase
FY146_13980	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
FY146_13985	COG4166	transmembrane transport
FY146_13990	COG4174	ABC transporter (Permease)
FY146_13995	COG4239	(ABC) transporter, permease
FY146_14000	COG4172	Belongs to the ABC transporter superfamily
FY146_14005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_14010	COG0174	glutamine synthetase
FY146_14015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_14020	COG3265	gluconokinase activity
FY146_14025	COG1174	glycine betaine transport
FY146_14030	COG1125	glycine betaine transport
FY146_14035	COG1174	glycine betaine transport
FY146_14040	COG1732	Glycine betaine
FY146_14050	COG1959	2 iron, 2 sulfur cluster binding
FY146_14055	COG1840	ABC-type Fe3 transport system, periplasmic component
FY146_14065	COG4269	membrane
FY146_14080	COG0697	spore germination
FY146_14095	COG0791	NLP P60 protein
FY146_14105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FY146_14110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FY146_14145	COG4964	Belongs to the GSP D family
FY146_14190	COG3422	double-strand break repair
FY146_14195	COG3757	hydrolase, family 25
FY146_14200	COG0697	spore germination
FY146_14205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_14220	COG0492	ferredoxin-NADP+ reductase activity
FY146_14235	COG0481	GTPase activity
FY146_14240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_14255	COG1396	sequence-specific DNA binding
FY146_14270	COG1917	Cupin 2, conserved barrel domain protein
FY146_14270	COG2169	Transcriptional regulator
FY146_14275	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY146_14300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FY146_14305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FY146_14310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FY146_14320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FY146_14325	COG0072	phenylalanine-tRNA ligase activity
FY146_14325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FY146_14330	COG0667	Aldo Keto reductase
FY146_14350	COG4977	sequence-specific DNA binding
FY146_14375	COG1570	exodeoxyribonuclease VII activity
FY146_14380	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_14390	COG1846	Transcriptional regulator
FY146_14400	COG2309	aminopeptidase activity
FY146_14410	COG1393	Belongs to the ArsC family
FY146_14425	COG1309	transcriptional regulator
FY146_14435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FY146_14435	COG0519	Catalyzes the synthesis of GMP from XMP
FY146_14450	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FY146_14480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FY146_14490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FY146_14500	COG1968	undecaprenyl-diphosphatase activity
FY146_14515	COG0284	orotidine-5'-phosphate decarboxylase activity
FY146_14525	COG3963	phosphatidate phosphatase activity
FY146_14535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FY146_14540	COG0792	nuclease activity
FY146_14555	COG1175	transmembrane transport
FY146_14560	COG0395	ABC-type sugar transport system, permease component
FY146_14565	COG3842	ATPase activity
FY146_14575	COG0189	ligase activity
FY146_14585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_14590	COG1280	lysine exporter protein (LysE YggA)
FY146_14595	COG0756	dUTP diphosphatase activity
FY146_14600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FY146_14605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FY146_14620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FY146_14625	COG2226	methyltransferase
FY146_14630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FY146_14635	COG1024	Enoyl-CoA hydratase
FY146_14640	COG0268	Binds directly to 16S ribosomal RNA
FY146_14665	COG0640	Transcriptional regulator
FY146_14705	COG4178	(ABC) transporter
FY146_14730	COG1082	Xylose isomerase domain protein TIM barrel
FY146_14735	COG0572	uridine kinase
FY146_14745	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_14750	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_14755	COG1129	ABC transporter
FY146_14775	COG3284	Transcriptional regulator
FY146_14780	COG1063	alcohol dehydrogenase
FY146_14790	COG0110	maltose O-acetyltransferase activity
FY146_14795	COG1049	propionate catabolic process, 2-methylcitrate cycle
FY146_14820	COG0488	(ABC) transporter
FY146_14825	COG5265	(ABC) transporter
FY146_14830	COG3181	Tripartite tricarboxylate transporter family receptor
FY146_14835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FY146_14845	COG3237	CsbD-like
FY146_14865	COG0395	ABC-type sugar transport system, permease component
FY146_14870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_14880	COG0483	inositol monophosphate 1-phosphatase activity
FY146_14890	COG0405	Gamma-glutamyltransferase
FY146_14895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_14900	COG0601	transmembrane transport
FY146_14905	COG0747	negative chemotaxis
FY146_14910	COG2186	Transcriptional regulator
FY146_14920	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_14925	COG4172	Belongs to the ABC transporter superfamily
FY146_14930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_14935	COG0601	transmembrane transport
FY146_14940	COG0747	negative chemotaxis
FY146_14945	COG2186	Transcriptional regulator
FY146_14955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_14960	COG2223	nitrite transmembrane transporter activity
FY146_14970	COG3383	formate dehydrogenase (NAD+) activity
FY146_14990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_15005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_15015	COG0765	amino acid transport
FY146_15020	COG0765	amino acid transport
FY146_15025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_15040	COG3938	Belongs to the proline racemase family
FY146_15050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_15060	COG0765	amino acid transport
FY146_15075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_15080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_15090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_15095	COG0784	Response regulator, receiver
FY146_15110	COG0842	Transport permease protein
FY146_15115	COG0842	Transport permease protein
FY146_15115	COG1129	ABC transporter
FY146_15120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_15125	COG1486	melibiose metabolic process
FY146_15130	COG4172	Belongs to the ABC transporter superfamily
FY146_15135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_15140	COG0601	transmembrane transport
FY146_15145	COG0747	negative chemotaxis
FY146_15150	COG1486	melibiose metabolic process
FY146_15175	COG1940	carbohydrate kinase activity
FY146_15180	COG2182	Extracellular solute-binding protein
FY146_15185	COG1175	transmembrane transport
FY146_15190	COG0395	ABC-type sugar transport system, permease component
FY146_15195	COG0165	Argininosuccinate lyase
FY146_15200	COG3842	ATPase activity
FY146_15205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_15210	COG3119	arylsulfatase activity
FY146_15220	COG0583	DNA-binding transcription factor activity
FY146_15225	COG1120	ATPase activity
FY146_15230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_15235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_15245	COG4774	siderophore transport
FY146_15255	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FY146_15270	COG2205	protein histidine kinase activity
FY146_15275	COG0745	RESPONSE REGULATOR receiver
FY146_15280	COG1566	PFAM secretion protein HlyD family protein
FY146_15295	COG1392	Phosphate transport regulator
FY146_15300	COG0306	phosphate transporter
FY146_15305	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY146_15315	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
FY146_15325	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_15330	COG5001	Diguanylate cyclase
FY146_15330	COG3300	MHYT domain
FY146_15350	COG2186	Transcriptional regulator
FY146_15355	COG0601	transmembrane transport
FY146_15360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_15365	COG0444	Belongs to the ABC transporter superfamily
FY146_15375	COG3842	ATPase activity
FY146_15380	COG0395	ABC-type sugar transport system, permease component
FY146_15395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_15395	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_15400	COG1609	Transcriptional regulator
FY146_15410	COG0210	DNA helicase
FY146_15415	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FY146_15420	COG1088	dTDP-glucose 4,6-dehydratase activity
FY146_15425	COG1091	dTDP-4-dehydrorhamnose reductase activity
FY146_15430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FY146_15445	COG3754	Rhamnan synthesis protein F
FY146_15450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_15470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FY146_15480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FY146_15485	COG1442	glycosyl transferase family 8
FY146_15485	COG1216	Glycosyl transferase, family 2
FY146_15500	COG1132	(ABC) transporter
FY146_15510	COG0583	DNA-binding transcription factor activity
FY146_15515	COG0667	Aldo Keto reductase
FY146_15535	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FY146_15550	COG0300	oxidoreductase activity
FY146_15555	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_15560	COG1940	carbohydrate kinase activity
FY146_15570	COG3712	iron ion homeostasis
FY146_15575	COG4774	siderophore transport
FY146_15580	COG2814	Major facilitator Superfamily
FY146_15600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY146_15610	COG3842	ATPase activity
FY146_15615	COG1175	transmembrane transport
FY146_15620	COG0395	ABC-type sugar transport system, permease component
FY146_15625	COG1609	Transcriptional regulator
FY146_15635	COG0673	inositol 2-dehydrogenase activity
FY146_15640	COG1082	Xylose isomerase domain protein TIM barrel
FY146_15655	COG1609	Transcriptional regulator
FY146_15660	COG0183	Belongs to the thiolase family
FY146_15665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FY146_15675	COG1414	Transcriptional regulator
FY146_15690	COG0583	DNA-binding transcription factor activity
FY146_15700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FY146_15705	COG3485	protocatechuate 3,4-dioxygenase
FY146_15710	COG3485	protocatechuate 3,4-dioxygenase
FY146_15715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FY146_15720	COG0765	amino acid transport
FY146_15725	COG0765	amino acid transport
FY146_15730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_15735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_15740	COG1126	abc transporter atp-binding protein
FY146_15745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FY146_15750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FY146_15775	COG4172	Belongs to the ABC transporter superfamily
FY146_15780	COG0747	negative chemotaxis
FY146_15790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_15805	COG0683	leucine binding
FY146_15820	COG0411	ABC transporter
FY146_15835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_15840	COG3962	Belongs to the TPP enzyme family
FY146_15850	COG3718	enzyme involved in inositol metabolism
FY146_15860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_15865	COG1609	Transcriptional regulator
FY146_15870	COG1846	Transcriptional regulator
FY146_15880	COG0523	cobalamin synthesis protein
FY146_15920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
FY146_15940	COG0800	Aldolase
FY146_15945	COG2954	triphosphatase activity
FY146_15955	COG1054	Belongs to the UPF0176 family
FY146_15960	COG3300	MHYT domain
FY146_15960	COG5001	Diguanylate cyclase
FY146_15970	COG2011	ABC-type metal ion transport system permease component
FY146_15975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY146_15980	COG0778	Nitroreductase
FY146_15990	COG2115	Belongs to the xylose isomerase family
FY146_15995	COG1070	Carbohydrate kinase
FY146_16000	COG1609	Transcriptional regulator
FY146_16020	COG1309	transcriptional regulator
FY146_16025	COG1253	flavin adenine dinucleotide binding
FY146_16030	COG0471	metal ion transport
FY146_16030	COG3273	potassium ion transport
FY146_16035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY146_16040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FY146_16045	COG1752	Esterase of the alpha-beta hydrolase superfamily
FY146_16055	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY146_16060	COG1121	(ABC) transporter
FY146_16065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_16070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FY146_16080	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_16085	COG1414	Transcriptional regulator
FY146_16090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FY146_16110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FY146_16160	COG0395	ABC-type sugar transport system, permease component
FY146_16165	COG1175	transmembrane transport
FY146_16175	COG2390	Transcriptional regulator
FY146_16180	COG4172	Belongs to the ABC transporter superfamily
FY146_16185	COG1473	amidohydrolase
FY146_16195	COG0601	transmembrane transport
FY146_16200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_16210	COG0693	protein deglycase activity
FY146_16215	COG0154	amidase activity
FY146_16220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_16230	COG0747	negative chemotaxis
FY146_16235	COG0583	DNA-binding transcription factor activity
FY146_16240	COG4608	Belongs to the ABC transporter superfamily
FY146_16245	COG0444	Belongs to the ABC transporter superfamily
FY146_16250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_16255	COG0601	transmembrane transport
FY146_16260	COG0747	negative chemotaxis
FY146_16275	COG1473	amidohydrolase
FY146_16280	COG2814	Major facilitator Superfamily
FY146_16285	COG0583	DNA-binding transcription factor activity
FY146_16290	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FY146_16300	COG3842	ATPase activity
FY146_16310	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_16320	COG1609	Transcriptional regulator
FY146_16325	COG0583	DNA-binding transcription factor activity
FY146_16330	COG1960	acyl-CoA dehydrogenase activity
FY146_16335	COG1629	transport
FY146_16335	COG4774	siderophore transport
FY146_16345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_16355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_16360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_16370	COG2375	cellular response to nickel ion
FY146_16380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY146_16385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FY146_16385	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FY146_16395	COG1169	isochorismate synthase
FY146_16400	COG1021	2,3-dihydroxybenzoate-AMP ligase
FY146_16405	COG1535	isochorismatase
FY146_16405	COG3433	isochorismatase activity
FY146_16410	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_16425	COG3005	denitrification pathway
FY146_16435	COG0243	molybdopterin cofactor binding
FY146_16450	COG4459	periplasmic nitrate reductase
FY146_16485	COG0826	peptidase U32
FY146_16495	COG3189	MarR family transcriptional regulator
FY146_16500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FY146_16530	COG3256	nitric oxide reductase
FY146_16535	COG0714	Associated with various cellular activities
FY146_16595	COG0673	inositol 2-dehydrogenase activity
FY146_16605	COG1609	Transcriptional regulator
FY146_16610	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_16615	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_16620	COG1129	ABC transporter
FY146_16625	COG1879	ABC-type sugar transport system periplasmic component
FY146_16635	COG0583	DNA-binding transcription factor activity
FY146_16650	COG1609	Transcriptional regulator
FY146_16655	COG0673	inositol 2-dehydrogenase activity
FY146_16665	COG1653	transport
FY146_16670	COG1175	transmembrane transport
FY146_16675	COG0395	ABC-type sugar transport system, permease component
FY146_16680	COG3842	ATPase activity
FY146_16695	COG1253	flavin adenine dinucleotide binding
FY146_16720	COG5001	Diguanylate cyclase
FY146_16720	COG3300	MHYT domain
FY146_16850	COG0477	Major facilitator Superfamily
FY146_16870	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_16880	COG1879	ABC-type sugar transport system periplasmic component
FY146_16890	COG1063	alcohol dehydrogenase
FY146_16905	COG1136	(ABC) transporter
FY146_16920	COG1309	transcriptional regulator
FY146_16940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FY146_16950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_16950	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_16960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_16965	COG0047	phosphoribosylformylglycinamidine synthase activity
FY146_16975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_16980	COG1012	belongs to the aldehyde dehydrogenase family
FY146_16985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_16995	COG4175	Glycine betaine
FY146_16995	COG3448	diguanylate cyclase activity
FY146_17005	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_17010	COG3938	Belongs to the proline racemase family
FY146_17015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FY146_17050	COG1733	regulation of RNA biosynthetic process
FY146_17100	COG0477	Major facilitator Superfamily
FY146_17110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FY146_17120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FY146_17135	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_17145	COG0395	ABC-type sugar transport system, permease component
FY146_17170	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_17175	COG1349	DNA-binding transcription factor activity
FY146_17180	COG1069	ribulokinase activity
FY146_17200	COG1940	carbohydrate kinase activity
FY146_17215	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_17220	COG1177	transmembrane transport
FY146_17230	COG3842	ATPase activity
FY146_17285	COG0577	efflux transmembrane transporter activity
FY146_17285	COG1136	(ABC) transporter
FY146_17310	COG1845	cytochrome c oxidase, subunit III
FY146_17315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FY146_17320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FY146_17325	COG3474	cytochrome
FY146_17355	COG3842	ATPase activity
FY146_17360	COG0395	ABC-type sugar transport system, permease component
FY146_17365	COG1175	transmembrane transport
FY146_17370	COG1653	transport
FY146_17375	COG1012	belongs to the aldehyde dehydrogenase family
FY146_17380	COG1024	Enoyl-CoA hydratase
FY146_17400	COG4702	Belongs to the UPF0303 family
FY146_17405	COG4774	siderophore transport
FY146_17405	COG1629	transport
FY146_17410	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FY146_17415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_17420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_17425	COG1120	ATPase activity
FY146_17440	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY146_17450	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY146_17455	COG1177	transmembrane transport
FY146_17460	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_17465	COG3842	ATPase activity
FY146_17490	COG1335	isochorismatase
FY146_17505	COG0583	DNA-binding transcription factor activity
FY146_17510	COG2318	DinB family
FY146_17535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FY146_17565	COG0778	Nitroreductase
FY146_17585	COG0277	FAD linked oxidase domain protein
FY146_17605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_17610	COG4172	Belongs to the ABC transporter superfamily
FY146_17620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_17630	COG0431	NADPH-dependent FMN reductase
FY146_17650	COG1522	sequence-specific DNA binding
FY146_17655	COG2376	Dihydroxyacetone kinase
FY146_17665	COG4221	oxidoreductase activity
FY146_17670	COG0625	glutathione transferase activity
FY146_17680	COG1566	PFAM secretion protein HlyD family protein
FY146_17690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FY146_17695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FY146_17710	COG0534	Mate efflux family protein
FY146_17745	COG1733	regulation of RNA biosynthetic process
FY146_17755	COG0577	efflux transmembrane transporter activity
FY146_17755	COG1136	(ABC) transporter
FY146_17760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_17770	COG0745	RESPONSE REGULATOR receiver
FY146_17790	COG3209	COG3209 Rhs family protein
FY146_17820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_17845	COG3177	Filamentation induced by cAMP protein fic
FY146_17860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_17865	COG4597	amino acid ABC transporter
FY146_17870	COG0765	amino acid transport
FY146_17895	COG0747	negative chemotaxis
FY146_17900	COG0601	transmembrane transport
FY146_17905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_17910	COG0444	Belongs to the ABC transporter superfamily
FY146_17915	COG4608	Belongs to the ABC transporter superfamily
FY146_17935	COG4213	ABC transporter substrate-binding protein
FY146_17940	COG1129	ABC transporter
FY146_17945	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_17960	COG0667	Aldo Keto reductase
FY146_17985	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_17990	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_17995	COG1129	ABC transporter
FY146_18005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_18015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_18025	COG0747	negative chemotaxis
FY146_18030	COG0747	negative chemotaxis
FY146_18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_18045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_18050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_18055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_18065	COG0405	Gamma-glutamyltransferase
FY146_18095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_18100	COG0436	Aminotransferase
FY146_18115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_18120	COG0765	amino acid transport
FY146_18130	COG1126	abc transporter atp-binding protein
FY146_18140	COG2186	Transcriptional regulator
FY146_18160	COG1846	Transcriptional regulator
FY146_18165	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_18175	COG0583	DNA-binding transcription factor activity
FY146_18210	COG0583	DNA-binding transcription factor activity
FY146_18230	COG1280	lysine exporter protein (LysE YggA)
FY146_18235	COG3920	Histidine kinase
FY146_18260	COG0753	catalase activity
FY146_18280	COG1278	Cold shock
FY146_18320	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_18325	COG1902	pentaerythritol trinitrate reductase activity
FY146_18330	COG4221	oxidoreductase activity
FY146_18335	COG1309	transcriptional regulator
FY146_18350	COG1280	lysine exporter protein (LysE YggA)
FY146_18360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FY146_18405	COG0741	lytic transglycosylase activity
FY146_18405	COG1196	nuclear chromosome segregation
FY146_18405	COG0739	heme binding
FY146_18410	COG0542	response to heat
FY146_18420	COG2890	protein-(glutamine-N5) methyltransferase activity
FY146_18425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FY146_18435	COG0527	aspartate kinase activity
FY146_18450	COG0019	diaminopimelate decarboxylase activity
FY146_18465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FY146_18485	COG0784	Response regulator, receiver
FY146_18500	COG1522	sequence-specific DNA binding
FY146_18510	COG1116	anion transmembrane transporter activity
FY146_18515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_18520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_18525	COG1012	belongs to the aldehyde dehydrogenase family
FY146_18530	COG0583	DNA-binding transcription factor activity
FY146_18535	COG0435	Glutathione S-transferase
FY146_18550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FY146_18555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_18560	COG0189	ligase activity
FY146_18580	COG0693	protein deglycase activity
FY146_18610	COG3685	Protein conserved in bacteria
FY146_18615	COG4993	Dehydrogenase
FY146_18630	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_18635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FY146_18680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_18695	COG0246	Mannitol dehydrogenase
FY146_18700	COG4608	Belongs to the ABC transporter superfamily
FY146_18705	COG0444	Belongs to the ABC transporter superfamily
FY146_18710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_18715	COG0601	transmembrane transport
FY146_18720	COG0747	negative chemotaxis
FY146_18730	COG4221	oxidoreductase activity
FY146_18760	COG0539	negative regulation of cytoplasmic translation
FY146_18765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FY146_18795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FY146_18800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FY146_18830	COG1294	oxidase, subunit
FY146_18840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FY146_18845	COG4988	ABC transporter
FY146_18855	COG1063	alcohol dehydrogenase
FY146_18860	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_18865	COG2084	Dehydrogenase
FY146_18875	COG1522	sequence-specific DNA binding
FY146_18880	COG1794	racemase activity, acting on amino acids and derivatives
FY146_18895	COG0058	SHG alpha-glucan phosphorylase activity
FY146_18900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FY146_18905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FY146_18910	COG0297	glycogen (starch) synthase activity
FY146_18915	COG0033	Phosphoglucomutase
FY146_18920	COG1523	belongs to the glycosyl hydrolase 13 family
FY146_18950	COG0446	pyridine nucleotide-disulphide oxidoreductase
FY146_18950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_18965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_18970	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY146_18990	COG1215	transferase activity, transferring glycosyl groups
FY146_18995	COG2327	Polysaccharide pyruvyl transferase
FY146_19000	COG0463	Glycosyl transferase, family 2
FY146_19005	COG2244	polysaccharide biosynthetic process
FY146_19010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY146_19015	COG2273	Hydrolase Family 16
FY146_19020	COG0438	transferase activity, transferring glycosyl groups
FY146_19025	COG1215	transferase activity, transferring glycosyl groups
FY146_19030	COG1215	transferase activity, transferring glycosyl groups
FY146_19035	COG1215	transferase activity, transferring glycosyl groups
FY146_19040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY146_19045	COG3206	protein involved in exopolysaccharide biosynthesis
FY146_19045	COG0489	protein tyrosine kinase activity
FY146_19050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_19055	COG0784	Response regulator, receiver
FY146_19055	COG4191	Histidine kinase
FY146_19070	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_19075	COG4175	Glycine betaine
FY146_19075	COG3448	diguanylate cyclase activity
FY146_19090	COG0564	pseudouridine synthase activity
FY146_19095	COG0500	methyltransferase
FY146_19105	COG2133	pyrroloquinoline quinone binding
FY146_19115	COG2197	response regulator
FY146_19120	COG4585	Histidine kinase
FY146_19125	COG1879	ABC-type sugar transport system periplasmic component
FY146_19130	COG1129	ABC transporter
FY146_19135	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_19145	COG3386	PFAM SMP-30 Gluconolaconase
FY146_19150	COG2137	regulation of response to DNA damage stimulus
FY146_19155	COG3474	cytochrome
FY146_19165	COG1120	ATPase activity
FY146_19180	COG4774	siderophore transport
FY146_19185	COG0583	DNA-binding transcription factor activity
FY146_19195	COG2194	sulfuric ester hydrolase activity
FY146_19210	COG0477	Major facilitator Superfamily
FY146_19235	COG0673	inositol 2-dehydrogenase activity
FY146_19240	COG0697	spore germination
FY146_19250	COG0010	Belongs to the arginase family
FY146_19265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FY146_19270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_19275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FY146_19280	COG0156	8-amino-7-oxononanoate synthase activity
FY146_19285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FY146_19335	COG0671	phosphoesterase, PA-phosphatase related
FY146_19340	COG0745	RESPONSE REGULATOR receiver
FY146_19345	COG2205	protein histidine kinase activity
FY146_19355	COG0477	Major facilitator Superfamily
FY146_19360	COG0583	DNA-binding transcription factor activity
FY146_19380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
FY146_19395	COG0346	lactoylglutathione lyase activity
FY146_19400	COG0583	DNA-binding transcription factor activity
FY146_19430	COG1215	transferase activity, transferring glycosyl groups
FY146_19450	COG0840	transmembrane signaling receptor activity
FY146_19465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_19480	COG2828	Protein conserved in bacteria
FY146_19485	COG0583	DNA-binding transcription factor activity
FY146_19490	COG1846	Transcriptional regulator
FY146_19515	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_19520	COG1309	transcriptional regulator
FY146_19525	COG2207	Transcriptional regulator
FY146_19540	COG1566	PFAM secretion protein HlyD family protein
FY146_19560	COG0395	ABC-type sugar transport system, permease component
FY146_19565	COG4166	transmembrane transport
FY146_19570	COG0601	transmembrane transport
FY146_19575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_19580	COG4172	Belongs to the ABC transporter superfamily
FY146_19620	COG0402	S-adenosylhomocysteine deaminase activity
FY146_19625	COG1228	amidohydrolase
FY146_19630	COG2986	histidine ammonia-lyase
FY146_19640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FY146_19670	COG1192	Involved in chromosome partitioning
FY146_19675	COG1475	DNA binding
FY146_19680	COG1414	Transcriptional regulator
FY146_19700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_19705	COG4771	TonB-dependent receptor
FY146_19715	COG0366	Alpha amylase catalytic
FY146_19720	COG4770	biotin carboxylase activity
FY146_19725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_19730	COG4336	lyase activity
FY146_19735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_19740	COG1914	H( )-stimulated, divalent metal cation uptake system
FY146_19745	COG1802	Transcriptional regulator
FY146_19750	COG3707	response regulator
FY146_19760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_19765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_19770	COG1116	anion transmembrane transporter activity
FY146_19775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FY146_19785	COG0243	molybdopterin cofactor binding
FY146_19790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FY146_19790	COG1648	precorrin-2 dehydrogenase activity
FY146_19805	COG3842	ATPase activity
FY146_19820	COG0395	ABC-type sugar transport system, permease component
FY146_19835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FY146_19850	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_19895	COG1879	ABC-type sugar transport system periplasmic component
FY146_19900	COG1129	ABC transporter
FY146_19905	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_19915	COG0667	Aldo Keto reductase
FY146_19920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FY146_19925	COG1830	Aldolase
FY146_19930	COG1070	Carbohydrate kinase
FY146_19935	COG0840	transmembrane signaling receptor activity
FY146_19950	COG0436	Aminotransferase
FY146_19960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FY146_19970	COG3842	ATPase activity
FY146_19975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_19980	COG1984	allophanate hydrolase subunit 2
FY146_19985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FY146_19995	COG0439	Biotin carboxylase
FY146_20000	COG0511	ligase activity, forming carbon-carbon bonds
FY146_20005	COG0697	spore germination
FY146_20010	COG0697	spore germination
FY146_20025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_20040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_20045	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_20050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_20055	COG4221	oxidoreductase activity
FY146_20060	COG0765	amino acid transport
FY146_20065	COG0765	amino acid transport
FY146_20075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_20080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_20085	COG1063	alcohol dehydrogenase
FY146_20100	COG1304	FMN binding
FY146_20125	COG3842	ATPase activity
FY146_20135	COG0395	ABC-type sugar transport system, permease component
FY146_20140	COG1175	transmembrane transport
FY146_20155	COG2186	Transcriptional regulator
FY146_20160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FY146_20165	COG0488	(ABC) transporter
FY146_20180	COG2308	Evidence 4 Homologs of previously reported genes of
FY146_20180	COG2307	Protein conserved in bacteria
FY146_20220	COG1454	alcohol dehydrogenase
FY146_20225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FY146_20235	COG0747	negative chemotaxis
FY146_20240	COG0601	transmembrane transport
FY146_20245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_20255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_20300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_20325	COG1082	Xylose isomerase domain protein TIM barrel
FY146_20330	COG0673	inositol 2-dehydrogenase activity
FY146_20335	COG1082	Xylose isomerase domain protein TIM barrel
FY146_20355	COG1609	Transcriptional regulator
FY146_20360	COG2986	histidine ammonia-lyase
FY146_20365	COG0517	IMP dehydrogenase activity
FY146_20365	COG4175	Glycine betaine
FY146_20370	COG4176	ABC-type proline glycine betaine transport system permease component
FY146_20410	COG2186	Transcriptional regulator
FY146_20415	COG1027	Aspartate ammonia-lyase
FY146_20425	COG0252	asparaginase activity
FY146_20435	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FY146_20440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FY146_20445	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FY146_20450	COG2205	protein histidine kinase activity
FY146_20465	COG0069	glutamate synthase activity
FY146_20465	COG0067	glutamate synthase
FY146_20465	COG0070	glutamate synthase
FY146_20480	COG2205	protein histidine kinase activity
FY146_20495	COG2951	lytic endotransglycosylase activity
FY146_20500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FY146_20525	COG0330	HflC and HflK could
FY146_20530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FY146_20535	COG0737	Belongs to the 5'-nucleotidase family
FY146_20545	COG5310	Homospermidine synthase
FY146_20555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FY146_20560	COG1164	Oligoendopeptidase f
FY146_20565	COG2204	response regulator
FY146_20570	COG3108	Peptidase M15
FY146_20575	COG0469	pyruvate kinase activity
FY146_20595	COG3750	Belongs to the UPF0335 family
FY146_20600	COG0457	Tetratricopeptide repeat
FY146_20605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FY146_20610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FY146_20615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FY146_20645	COG0483	inositol monophosphate 1-phosphatase activity
FY146_20665	COG1132	(ABC) transporter
FY146_20670	COG0254	rRNA binding
FY146_20690	COG3588	fructose-bisphosphate aldolase
FY146_20695	COG0126	phosphoglycerate kinase activity
FY146_20735	COG1253	flavin adenine dinucleotide binding
FY146_20745	COG1692	metallophosphoesterase
FY146_20760	COG0217	transcriptional regulatory protein
FY146_20765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_20770	COG0840	transmembrane signaling receptor activity
FY146_20775	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FY146_20780	COG0632	four-way junction helicase activity
FY146_20785	COG2255	four-way junction helicase activity
FY146_20800	COG0494	nUDIX hydrolase
FY146_20810	COG0824	Thioesterase
FY146_20830	COG0823	Involved in the tonB-independent uptake of proteins
FY146_20835	COG2885	chlorophyll binding
FY146_20845	COG0037	tRNA processing
FY146_20850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_20855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FY146_20870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_20885	COG0482	sulfurtransferase activity
FY146_20915	COG2835	tetraacyldisaccharide 4'-kinase activity
FY146_20920	COG2373	Large extracellular alpha-helical protein
FY146_20925	COG4953	penicillin-binding protein 1C
FY146_20935	COG1473	amidohydrolase
FY146_20940	COG1686	Belongs to the peptidase S11 family
FY146_20945	COG0523	cobalamin synthesis protein
FY146_20950	COG0425	Belongs to the sulfur carrier protein TusA family
FY146_20950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FY146_20955	COG3034	peptidoglycan biosynthetic process
FY146_20960	COG0825	malonyl-CoA metabolic process
FY146_20965	COG4974	Belongs to the 'phage' integrase family
FY146_20975	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FY146_20980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FY146_21020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FY146_21025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FY146_21045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_21050	COG2226	methyltransferase
FY146_21055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FY146_21060	COG0287	Prephenate dehydrogenase
FY146_21070	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY146_21090	COG2884	Cell division ATP-binding protein ftsE
FY146_21125	COG0165	Argininosuccinate lyase
FY146_21130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FY146_21140	COG1250	3-hydroxyacyl-CoA dehydrogenase
FY146_21150	COG2086	electron transfer activity
FY146_21160	COG2096	Adenosyltransferase
FY146_21170	COG0300	oxidoreductase activity
FY146_21180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FY146_21190	COG1396	sequence-specific DNA binding
FY146_21190	COG3800	Transcriptional regulator
FY146_21195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY146_21200	COG0625	glutathione transferase activity
FY146_21215	COG4770	biotin carboxylase activity
FY146_21220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY146_21220	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FY146_21225	COG0346	lactoylglutathione lyase activity
FY146_21240	COG4213	ABC transporter substrate-binding protein
FY146_21245	COG4214	carbohydrate transport
FY146_21250	COG1129	ABC transporter
FY146_21255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FY146_21265	COG1396	sequence-specific DNA binding
FY146_21320	COG3833	ABC-type maltose transport systems, permease component
FY146_21325	COG3842	ATPase activity
FY146_21340	COG2273	Hydrolase Family 16
FY146_21340	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FY146_21345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FY146_21360	COG0438	transferase activity, transferring glycosyl groups
FY146_21365	COG0438	transferase activity, transferring glycosyl groups
FY146_21385	COG3206	protein involved in exopolysaccharide biosynthesis
FY146_21385	COG0489	protein tyrosine kinase activity
FY146_21395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FY146_21410	COG2244	polysaccharide biosynthetic process
FY146_21475	COG0697	spore germination
FY146_21480	COG0653	protein targeting
FY146_21485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FY146_21490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FY146_21500	COG0494	nUDIX hydrolase
FY146_21515	COG2226	methyltransferase
FY146_21520	COG1040	competence protein
FY146_21530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_21540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_21555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FY146_21560	COG4150	thiosulfate binding
FY146_21570	COG4208	sulfate ABC transporter
FY146_21575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FY146_21580	COG4335	DNA alkylation repair
FY146_21595	COG5001	Diguanylate cyclase
FY146_21600	COG2264	protein methyltransferase activity
FY146_21615	COG3254	rhamnose metabolic process
FY146_21620	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_21625	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_21630	COG1129	ABC transporter
FY146_21640	COG1349	DNA-binding transcription factor activity
FY146_21645	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_21645	COG3347	Dehydrogenase
FY146_21650	COG4952	isomerase
FY146_21655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FY146_21660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FY146_21680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FY146_21685	COG1960	acyl-CoA dehydrogenase activity
FY146_21695	COG0183	Belongs to the thiolase family
FY146_21700	COG1960	acyl-CoA dehydrogenase activity
FY146_21710	COG0022	dehydrogenase e1 component
FY146_21720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FY146_21725	COG2391	methyltransferase activity
FY146_21735	COG0640	Transcriptional regulator
FY146_21740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FY146_21740	COG3453	Protein conserved in bacteria
FY146_21750	COG0300	oxidoreductase activity
FY146_21765	COG2186	Transcriptional regulator
FY146_21775	COG0601	transmembrane transport
FY146_21785	COG0444	Belongs to the ABC transporter superfamily
FY146_21790	COG4608	Belongs to the ABC transporter superfamily
FY146_21920	COG2369	cell adhesion
FY146_21925	COG4383	Mu-like prophage protein gp29
FY146_21930	COG4373	Mu-like prophage FluMu protein gp28
FY146_22065	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_22070	COG1733	regulation of RNA biosynthetic process
FY146_22080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22105	COG1473	amidohydrolase
FY146_22110	COG0747	negative chemotaxis
FY146_22125	COG4166	transmembrane transport
FY146_22130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22135	COG0583	DNA-binding transcription factor activity
FY146_22145	COG0667	Aldo Keto reductase
FY146_22155	COG0444	Belongs to the ABC transporter superfamily
FY146_22170	COG0747	negative chemotaxis
FY146_22180	COG1960	acyl-CoA dehydrogenase activity
FY146_22210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FY146_22225	COG1959	2 iron, 2 sulfur cluster binding
FY146_22230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22240	COG1473	amidohydrolase
FY146_22250	COG1126	abc transporter atp-binding protein
FY146_22255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_22265	COG0583	DNA-binding transcription factor activity
FY146_22280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_22290	COG1522	sequence-specific DNA binding
FY146_22295	COG4172	Belongs to the ABC transporter superfamily
FY146_22300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_22335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_22340	COG1012	belongs to the aldehyde dehydrogenase family
FY146_22345	COG0473	3-isopropylmalate dehydrogenase activity
FY146_22350	COG1012	belongs to the aldehyde dehydrogenase family
FY146_22395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_22400	COG1120	ATPase activity
FY146_22410	COG2226	methyltransferase
FY146_22425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_22430	COG1120	ATPase activity
FY146_22435	COG1595	DNA-templated transcription, initiation
FY146_22455	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
FY146_22460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_22480	COG0673	inositol 2-dehydrogenase activity
FY146_22485	COG0673	inositol 2-dehydrogenase activity
FY146_22495	COG1175	transmembrane transport
FY146_22500	COG0395	ABC-type sugar transport system, permease component
FY146_22505	COG3842	ATPase activity
FY146_22515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_22520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_22525	COG2197	response regulator
FY146_22530	COG0601	transmembrane transport
FY146_22535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_22555	COG0747	negative chemotaxis
FY146_22570	COG1446	asparaginase
FY146_22575	COG0583	DNA-binding transcription factor activity
FY146_22580	COG0601	transmembrane transport
FY146_22585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_22600	COG0747	negative chemotaxis
FY146_22605	COG1473	amidohydrolase
FY146_22620	COG1129	ABC transporter
FY146_22625	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_22630	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FY146_22635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FY146_22645	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_22660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_22670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_22675	COG2079	MmgE PrpD family protein
FY146_22680	COG1126	abc transporter atp-binding protein
FY146_22685	COG0765	amino acid transport
FY146_22700	COG0281	malic enzyme
FY146_22700	COG0280	phosphate acetyltransferase
FY146_22705	COG0583	DNA-binding transcription factor activity
FY146_22730	COG1175	transmembrane transport
FY146_22735	COG0395	ABC-type sugar transport system, permease component
FY146_22750	COG0673	inositol 2-dehydrogenase activity
FY146_22755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FY146_22760	COG0720	synthase
FY146_22765	COG0602	queuosine metabolic process
FY146_22770	COG0673	inositol 2-dehydrogenase activity
FY146_22780	COG3842	ATPase activity
FY146_22795	COG1653	transport
FY146_22800	COG1609	Transcriptional regulator
FY146_22815	COG2094	Belongs to the DNA glycosylase MPG family
FY146_22825	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_22835	COG1376	ErfK ybiS ycfS ynhG family protein
FY146_22840	COG0840	transmembrane signaling receptor activity
FY146_22845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_22855	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FY146_22860	COG1596	polysaccharide export
FY146_22865	COG3307	-O-antigen
FY146_22895	COG2197	response regulator
FY146_22905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_22930	COG2942	2-epimerase
FY146_22940	COG1215	transferase activity, transferring glycosyl groups
FY146_22960	COG1473	amidohydrolase
FY146_22970	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_22975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FY146_22980	COG1301	dicarboxylic acid transport
FY146_22985	COG4191	Histidine kinase
FY146_22990	COG2204	response regulator
FY146_23005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_23010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FY146_23015	COG1522	sequence-specific DNA binding
FY146_23020	COG0351	phosphomethylpyrimidine kinase
FY146_23025	COG0352	thiamine-phosphate diphosphorylase activity
FY146_23030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FY146_23035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_23040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_23050	COG1501	Belongs to the glycosyl hydrolase 31 family
FY146_23055	COG0395	ABC-type sugar transport system, permease component
FY146_23060	COG1175	transmembrane transport
FY146_23065	COG1653	transport
FY146_23070	COG3842	ATPase activity
FY146_23075	COG2188	Transcriptional regulator
FY146_23085	COG4989	oxidoreductase activity
FY146_23120	COG0438	transferase activity, transferring glycosyl groups
FY146_23125	COG0747	negative chemotaxis
FY146_23130	COG0601	transmembrane transport
FY146_23140	COG3964	amidohydrolase
FY146_23155	COG1921	L-seryl-tRNASec selenium transferase activity
FY146_23160	COG4172	Belongs to the ABC transporter superfamily
FY146_23165	COG0625	glutathione transferase activity
FY146_23180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_23185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_23185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FY146_23190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_23210	COG1312	Catalyzes the dehydration of D-mannonate
FY146_23215	COG1063	alcohol dehydrogenase
FY146_23220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FY146_23230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_23235	COG2186	Transcriptional regulator
FY146_23240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FY146_23245	COG0850	regulation of cytokinetic process
FY146_23250	COG2894	cell division
FY146_23255	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FY146_23260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_23270	COG5001	Diguanylate cyclase
FY146_23285	COG0673	inositol 2-dehydrogenase activity
FY146_23295	COG1653	transport
FY146_23300	COG1175	transmembrane transport
FY146_23305	COG0395	ABC-type sugar transport system, permease component
FY146_23310	COG3842	ATPase activity
FY146_23320	COG0673	inositol 2-dehydrogenase activity
FY146_23350	COG0587	DNA-directed DNA polymerase activity
FY146_23355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FY146_23370	COG2186	Transcriptional regulator
FY146_23375	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_23380	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_23385	COG1129	ABC transporter
FY146_23390	COG1879	ABC-type sugar transport system periplasmic component
FY146_23395	COG0129	dihydroxy-acid dehydratase activity
FY146_23405	COG0346	lactoylglutathione lyase activity
FY146_23420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FY146_23425	COG4608	Belongs to the ABC transporter superfamily
FY146_23435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_23440	COG0601	transmembrane transport
FY146_23445	COG0747	negative chemotaxis
FY146_23455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FY146_23460	COG5001	Diguanylate cyclase
FY146_23470	COG3257	ureidoglycine aminohydrolase activity
FY146_23480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_23485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_23495	COG1129	ABC transporter
FY146_23500	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_23505	COG1879	ABC-type sugar transport system periplasmic component
FY146_23510	COG0583	DNA-binding transcription factor activity
FY146_23535	COG3047	cAMP biosynthetic process
FY146_23545	COG3842	ATPase activity
FY146_23550	COG0395	ABC-type sugar transport system, permease component
FY146_23555	COG1175	transmembrane transport
FY146_23560	COG1653	transport
FY146_23565	COG0523	cobalamin synthesis protein
FY146_23580	COG0523	cobalamin synthesis protein
FY146_23585	COG1121	(ABC) transporter
FY146_23595	COG0803	Belongs to the bacterial solute-binding protein 9 family
FY146_23600	COG0454	-acetyltransferase
FY146_23615	COG0626	cystathionine gamma-synthase activity
FY146_23620	COG2182	Extracellular solute-binding protein
FY146_23630	COG0395	ABC-type sugar transport system, permease component
FY146_23645	COG0395	ABC-type sugar transport system, permease component
FY146_23650	COG1175	transmembrane transport
FY146_23655	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
FY146_23660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FY146_23670	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_23675	COG1063	alcohol dehydrogenase
FY146_23680	COG1609	Transcriptional regulator
FY146_23685	COG2223	nitrite transmembrane transporter activity
FY146_23690	COG4977	sequence-specific DNA binding
FY146_23720	COG0667	Aldo Keto reductase
FY146_23735	COG2186	Transcriptional regulator
FY146_23740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FY146_23745	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FY146_23750	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_23755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FY146_23760	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_23765	COG3618	amidohydrolase
FY146_23775	COG1175	transmembrane transport
FY146_23780	COG0395	ABC-type sugar transport system, permease component
FY146_23785	COG3842	ATPase activity
FY146_23800	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FY146_23805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FY146_23825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FY146_23835	COG1278	Cold shock
FY146_23840	COG0673	inositol 2-dehydrogenase activity
FY146_23855	COG0673	inositol 2-dehydrogenase activity
FY146_23860	COG1309	transcriptional regulator
FY146_23865	COG1653	transport
FY146_23870	COG1175	transmembrane transport
FY146_23875	COG0395	ABC-type sugar transport system, permease component
FY146_23880	COG3842	ATPase activity
FY146_23885	COG1082	Xylose isomerase domain protein TIM barrel
FY146_23900	COG1609	Transcriptional regulator
FY146_23930	COG1175	transmembrane transport
FY146_23935	COG0395	ABC-type sugar transport system, permease component
FY146_23940	COG1116	anion transmembrane transporter activity
FY146_23945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_23950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_23965	COG3842	ATPase activity
FY146_23970	COG0395	ABC-type sugar transport system, permease component
FY146_23980	COG1653	transport
FY146_24015	COG3842	ATPase activity
FY146_24025	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_24030	COG0395	ABC-type sugar transport system, permease component
FY146_24090	COG2233	PERMEase
FY146_24105	COG5002	protein histidine kinase activity
FY146_24110	COG0745	RESPONSE REGULATOR receiver
FY146_24115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FY146_24120	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FY146_24125	COG0702	epimerase
FY146_24135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FY146_24170	COG2235	arginine
FY146_24180	COG0628	permease
FY146_24205	COG1522	sequence-specific DNA binding
FY146_24225	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_24240	COG1414	Transcriptional regulator
FY146_24250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FY146_24280	COG4566	intracellular signal transduction
FY146_24285	COG4566	intracellular signal transduction
FY146_24295	COG0243	molybdopterin cofactor binding
FY146_24300	COG0783	Belongs to the Dps family
FY146_24315	COG0596	Alpha beta hydrolase
FY146_24325	COG1764	response to oxidative stress
FY146_24340	COG0596	Alpha beta hydrolase
FY146_24375	COG4172	Belongs to the ABC transporter superfamily
FY146_24400	COG0601	transmembrane transport
FY146_24405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_24410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_24420	COG4106	trans-aconitate 2-methyltransferase activity
FY146_24425	COG0025	NhaP-type Na H and K H
FY146_24430	COG4302	ethanolamine ammonia-lyase activity
FY146_24455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_24460	COG1349	DNA-binding transcription factor activity
FY146_24465	COG4608	Belongs to the ABC transporter superfamily
FY146_24475	COG0601	transmembrane transport
FY146_24480	COG0747	negative chemotaxis
FY146_24485	COG1454	alcohol dehydrogenase
FY146_24490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FY146_24495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FY146_24500	COG0411	ABC transporter
FY146_24535	COG1278	Cold shock
FY146_24565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FY146_24575	COG1192	Involved in chromosome partitioning
FY146_24580	COG1475	DNA binding
FY146_24585	COG0640	Transcriptional regulator
FY146_24600	COG1126	abc transporter atp-binding protein
FY146_24605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_24610	COG1609	Transcriptional regulator
FY146_24645	COG3239	Fatty acid desaturase
FY146_24655	COG1278	Cold shock
FY146_24730	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FY146_24730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FY146_24765	COG4191	Histidine kinase
FY146_24770	COG1132	(ABC) transporter
FY146_24780	COG0640	Transcriptional regulator
FY146_24810	COG4977	sequence-specific DNA binding
FY146_24815	COG2211	Major facilitator Superfamily
FY146_24820	COG2807	transmembrane transport
FY146_24825	COG1846	Transcriptional regulator
FY146_24840	COG2814	Major facilitator Superfamily
FY146_24870	COG3443	Belongs to the bacterial solute-binding protein 9 family
FY146_24885	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FY146_24890	COG0583	DNA-binding transcription factor activity
FY146_24905	COG0071	Belongs to the small heat shock protein (HSP20) family
FY146_24950	COG3838	Conjugal transfer protein Trbc
FY146_24955	COG3702	type iv secretory pathway
FY146_24960	COG3451	type IV secretory pathway VirB4
FY146_24975	COG3704	protein secretion by the type IV secretion system
FY146_24985	COG3736	Type IV secretory pathway, component VirB8
FY146_24990	COG3504	Conjugal transfer protein
FY146_24995	COG2948	multi-organism process
FY146_25000	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
FY146_25100	COG3831	ATPase activity
FY146_25115	COG3505	Type IV secretory pathway VirD4
FY146_25140	COG0583	DNA-binding transcription factor activity
FY146_25180	COG0745	RESPONSE REGULATOR receiver
FY146_25220	COG3842	ATPase activity
FY146_25225	COG4208	sulfate ABC transporter
FY146_25230	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_25250	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FY146_25255	COG1942	4-Oxalocrotonate Tautomerase
FY146_25265	COG3971	2-oxopent-4-enoate hydratase activity
FY146_25275	COG1414	Transcriptional regulator
FY146_25285	COG1137	ATPase activity
FY146_25300	COG4177	L-phenylalanine transmembrane transporter activity
FY146_25320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FY146_25325	COG1175	transmembrane transport
FY146_25330	COG0395	ABC-type sugar transport system, permease component
FY146_25340	COG0366	Alpha amylase catalytic
FY146_25345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FY146_25350	COG1082	Xylose isomerase domain protein TIM barrel
FY146_25355	COG3842	ATPase activity
FY146_25365	COG1940	carbohydrate kinase activity
FY146_25370	COG0395	ABC-type sugar transport system, permease component
FY146_25380	COG2182	Extracellular solute-binding protein
FY146_25385	COG0673	inositol 2-dehydrogenase activity
FY146_25415	COG1126	abc transporter atp-binding protein
FY146_25420	COG0765	amino acid transport
FY146_25425	COG0765	amino acid transport
FY146_25435	COG4608	Belongs to the ABC transporter superfamily
FY146_25445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_25460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_25465	COG0583	DNA-binding transcription factor activity
FY146_25470	COG2423	ornithine cyclodeaminase activity
FY146_25480	COG1957	nucleoside hydrolase
FY146_25500	COG1335	isochorismatase
FY146_25505	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_25540	COG3547	Transposase (IS116 IS110 IS902 family)
FY146_25545	COG0251	oxidation-reduction process
FY146_25550	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
FY146_25605	COG4215	(ABC) transporter
FY146_25615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_25630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_25640	COG0747	negative chemotaxis
FY146_25660	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FY146_25695	COG0477	Major facilitator Superfamily
FY146_25705	COG0395	ABC-type sugar transport system, permease component
FY146_25710	COG1175	transmembrane transport
FY146_25715	COG3842	ATPase activity
FY146_25725	COG4948	Mandelate Racemase Muconate Lactonizing
FY146_25735	COG1414	Transcriptional regulator
FY146_25740	COG0583	DNA-binding transcription factor activity
FY146_25775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FY146_25785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FY146_25810	COG1129	ABC transporter
FY146_25830	COG2272	Belongs to the type-B carboxylesterase lipase family
FY146_25840	COG2271	Major facilitator Superfamily
FY146_25845	COG0583	DNA-binding transcription factor activity
FY146_25870	COG1129	ABC transporter
FY146_25880	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_25885	COG1940	carbohydrate kinase activity
FY146_25910	COG2084	Dehydrogenase
FY146_25915	COG3622	Belongs to the hyi family
FY146_25920	COG3386	PFAM SMP-30 Gluconolaconase
FY146_25930	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FY146_25940	COG1012	belongs to the aldehyde dehydrogenase family
FY146_25980	COG1846	Transcriptional regulator
FY146_26000	COG3706	GGDEF domain
FY146_26015	COG0477	Major facilitator Superfamily
FY146_26020	COG1012	belongs to the aldehyde dehydrogenase family
FY146_26030	COG1024	Enoyl-CoA hydratase
FY146_26035	COG1960	acyl-CoA dehydrogenase activity
FY146_26045	COG1063	alcohol dehydrogenase
FY146_26060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FY146_26065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FY146_26080	COG3971	2-oxopent-4-enoate hydratase activity
FY146_26085	COG3485	protocatechuate 3,4-dioxygenase
FY146_26090	COG1802	Transcriptional regulator
FY146_26105	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_26150	COG2207	Transcriptional regulator
FY146_26230	COG1695	Transcriptional regulator
FY146_26240	COG0583	DNA-binding transcription factor activity
FY146_26245	COG1335	isochorismatase
FY146_26255	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_26260	COG0583	DNA-binding transcription factor activity
FY146_26265	COG1902	pentaerythritol trinitrate reductase activity
FY146_26270	COG0583	DNA-binding transcription factor activity
FY146_26315	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_26320	COG1335	isochorismatase
FY146_26330	COG1309	transcriptional regulator
FY146_26335	COG4604	ABC transporter, ATP-binding protein
FY146_26340	COG4605	iron ion homeostasis
FY146_26345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FY146_26355	COG2132	Multicopper oxidase
FY146_26360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FY146_26365	COG4771	TonB-dependent receptor
FY146_26400	COG1695	Transcriptional regulator
FY146_26435	COG2132	Multicopper oxidase
FY146_26470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FY146_26490	COG1192	Involved in chromosome partitioning
FY146_26495	COG1475	DNA binding
FY146_26500	COG0640	Transcriptional regulator
FY146_26505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_26535	COG2211	Major facilitator Superfamily
FY146_26585	COG1051	belongs to the nudix hydrolase family
FY146_26625	COG1475	DNA binding
FY146_26650	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_26670	COG1280	lysine exporter protein (LysE YggA)
FY146_26685	COG5489	Protein of unknown function (DUF736)
FY146_26745	COG1879	ABC-type sugar transport system periplasmic component
FY146_26750	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_26770	COG1280	lysine exporter protein (LysE YggA)
FY146_26855	COG1283	sodium-dependent phosphate transmembrane transporter activity
FY146_26870	COG0747	negative chemotaxis
FY146_26875	COG0444	Belongs to the ABC transporter superfamily
FY146_26890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_26895	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_26900	COG0483	inositol monophosphate 1-phosphatase activity
FY146_26965	COG3161	chorismate lyase activity
FY146_27115	COG3436	PFAM IS66 Orf2 family protein
FY146_27195	COG2222	sugar isomerase
FY146_27205	COG0006	proline dipeptidase activity
FY146_27225	COG1177	transmembrane transport
FY146_27230	COG1176	ABC-type spermidine putrescine transport system, permease component I
FY146_27235	COG3842	ATPase activity
FY146_27265	COG3842	ATPase activity
FY146_27270	COG0006	proline dipeptidase activity
FY146_27290	COG0300	oxidoreductase activity
FY146_27295	COG0129	dihydroxy-acid dehydratase activity
FY146_27300	COG0667	Aldo Keto reductase
FY146_27310	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_27320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_27325	COG0601	transmembrane transport
FY146_27330	COG4172	Belongs to the ABC transporter superfamily
FY146_27340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FY146_27375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_27410	COG3701	Conjugal transfer protein
FY146_27415	COG3846	protein secretion by the type IV secretion system
FY146_27425	COG5314	conjugation
FY146_27430	COG3451	type IV secretory pathway VirB4
FY146_27445	COG4962	Type ii secretion system protein e
FY146_27455	COG1192	Involved in chromosome partitioning
FY146_27460	COG1475	DNA binding
FY146_27465	COG0640	Transcriptional regulator
FY146_27470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FY146_27515	COG0583	DNA-binding transcription factor activity
FY146_27525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FY146_27530	COG1116	anion transmembrane transporter activity
FY146_27535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FY146_27545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_27550	COG1028	Short-chain dehydrogenase reductase Sdr
FY146_27580	COG1172	Belongs to the binding-protein-dependent transport system permease family
FY146_27585	COG1129	ABC transporter
FY146_27610	COG4172	Belongs to the ABC transporter superfamily
FY146_27615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_27620	COG0601	transmembrane transport
FY146_27630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_27635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_27640	COG0583	DNA-binding transcription factor activity
FY146_27650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FY146_27665	COG1132	(ABC) transporter
FY146_27670	COG4172	Belongs to the ABC transporter superfamily
FY146_27675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_27695	COG1082	Xylose isomerase domain protein TIM barrel
FY146_27700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FY146_27705	COG0019	diaminopimelate decarboxylase activity
FY146_27715	COG1475	DNA binding
FY146_27725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FY146_27815	COG1475	DNA binding
FY146_27840	COG2824	Alkylphosphonate utilization operon protein PhnA
FY146_27865	COG5489	Protein of unknown function (DUF736)
FY146_27925	COG0583	DNA-binding transcription factor activity
FY146_27930	COG1126	abc transporter atp-binding protein
FY146_27935	COG0765	amino acid transport
FY146_27940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FY146_27945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_27950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FY146_28010	COG0584	glycerophosphoryl diester phosphodiesterase
FY146_28020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_28035	COG0444	Belongs to the ABC transporter superfamily
FY146_28060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FY146_28065	COG0601	transmembrane transport
FY146_28080	COG0444	Belongs to the ABC transporter superfamily
FY146_28085	COG0747	negative chemotaxis
FY146_28095	COG2390	Transcriptional regulator
FY146_28140	COG0145	ligase activity
FY146_28150	COG0583	DNA-binding transcription factor activity
FY146_28195	COG3701	Conjugal transfer protein
FY146_28200	COG3846	protein secretion by the type IV secretion system
FY146_28215	COG3451	type IV secretory pathway VirB4
FY146_28230	COG4962	Type ii secretion system protein e