locus-tag	class	description
HRS00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HRS00_00025	COG0640	Transcriptional regulator
HRS00_00030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRS00_00035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HRS00_00040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HRS00_00045	COG1420	regulation of RNA biosynthetic process
HRS00_00050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HRS00_00060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRS00_00065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HRS00_00075	COG1137	ATPase activity
HRS00_00080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HRS00_00095	COG0776	regulation of translation
HRS00_00105	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HRS00_00105	COG0116	Belongs to the methyltransferase superfamily
HRS00_00110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRS00_00115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HRS00_00120	COG2205	protein histidine kinase activity
HRS00_00120	COG3437	response regulator, receiver
HRS00_00120	COG3850	Histidine kinase
HRS00_00120	COG4999	Histidine kinase
HRS00_00130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HRS00_00135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HRS00_00140	COG0728	peptidoglycan biosynthetic process
HRS00_00145	COG0180	Tryptophanyl-tRNA synthetase
HRS00_00155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HRS00_00160	COG1214	PFAM Peptidase M22, glycoprotease
HRS00_00180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRS00_00185	COG1702	phosphate starvation-inducible protein PhoH
HRS00_00190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HRS00_00195	COG1253	flavin adenine dinucleotide binding
HRS00_00200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HRS00_00205	COG1396	sequence-specific DNA binding
HRS00_00210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HRS00_00215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HRS00_00220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRS00_00230	COG0242	peptide deformylase activity
HRS00_00235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HRS00_00240	COG0101	tRNA pseudouridine synthase activity
HRS00_00245	COG1393	Belongs to the ArsC family
HRS00_00255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRS00_00260	COG2171	N-acyltransferase activity
HRS00_00270	COG1957	nucleoside hydrolase
HRS00_00275	COG0071	Belongs to the small heat shock protein (HSP20) family
HRS00_00300	COG2188	Transcriptional regulator
HRS00_00310	COG0848	biopolymer transport protein
HRS00_00320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HRS00_00325	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRS00_00330	COG3454	Phosphonate metabolism
HRS00_00335	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HRS00_00340	COG0588	phosphoglycerate mutase activity
HRS00_00345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HRS00_00350	COG1132	(ABC) transporter
HRS00_00355	COG0837	glucose binding
HRS00_00360	COG1803	Methylglyoxal synthase
HRS00_00365	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
HRS00_00370	COG4166	transmembrane transport
HRS00_00375	COG4174	ABC transporter (Permease)
HRS00_00380	COG4239	(ABC) transporter, permease
HRS00_00385	COG4172	Belongs to the ABC transporter superfamily
HRS00_00390	COG0174	glutamine synthetase
HRS00_00395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_00400	COG3265	gluconokinase activity
HRS00_00405	COG1174	glycine betaine transport
HRS00_00410	COG1125	glycine betaine transport
HRS00_00415	COG1174	glycine betaine transport
HRS00_00420	COG1732	Glycine betaine
HRS00_00430	COG1959	2 iron, 2 sulfur cluster binding
HRS00_00435	COG1840	ABC-type Fe3 transport system, periplasmic component
HRS00_00445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRS00_00455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRS00_00460	COG3618	amidohydrolase
HRS00_00465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRS00_00480	COG0477	Major facilitator Superfamily
HRS00_00490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRS00_00495	COG1845	cytochrome c oxidase, subunit III
HRS00_00500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HRS00_00510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HRS00_00515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HRS00_00520	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HRS00_00545	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HRS00_00555	COG2986	histidine ammonia-lyase
HRS00_00560	COG1228	amidohydrolase
HRS00_00570	COG0697	spore germination
HRS00_00575	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_00590	COG0791	NLP P60 protein
HRS00_00600	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HRS00_00605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRS00_00640	COG4964	Belongs to the GSP D family
HRS00_00680	COG1396	sequence-specific DNA binding
HRS00_00685	COG0481	GTPase activity
HRS00_00695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRS00_00700	COG0697	spore germination
HRS00_00710	COG0840	transmembrane signaling receptor activity
HRS00_00710	COG2972	Histidine kinase
HRS00_00720	COG1917	Cupin 2, conserved barrel domain protein
HRS00_00720	COG2169	Transcriptional regulator
HRS00_00725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRS00_00735	COG0251	oxidation-reduction process
HRS00_00740	COG1309	transcriptional regulator
HRS00_00755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HRS00_00760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HRS00_00765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HRS00_00775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HRS00_00785	COG0072	phenylalanine-tRNA ligase activity
HRS00_00785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRS00_00800	COG0667	Aldo Keto reductase
HRS00_00815	COG4977	sequence-specific DNA binding
HRS00_00840	COG1570	exodeoxyribonuclease VII activity
HRS00_00845	COG0189	ligase activity
HRS00_00855	COG3842	ATPase activity
HRS00_00860	COG0395	ABC-type sugar transport system, permease component
HRS00_00865	COG1175	transmembrane transport
HRS00_00870	COG1653	transport
HRS00_00875	COG0792	nuclease activity
HRS00_00880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HRS00_00890	COG3963	phosphatidate phosphatase activity
HRS00_00900	COG0284	orotidine-5'-phosphate decarboxylase activity
HRS00_00920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HRS00_00930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HRS00_00960	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HRS00_00975	COG0519	Catalyzes the synthesis of GMP from XMP
HRS00_00975	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HRS00_00990	COG1393	Belongs to the ArsC family
HRS00_01000	COG2309	aminopeptidase activity
HRS00_01005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HRS00_01010	COG0756	dUTP diphosphatase activity
HRS00_01075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRS00_01080	COG0606	chelatase, subunit chli
HRS00_01085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRS00_01110	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HRS00_01120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HRS00_01125	COG0706	membrane insertase activity
HRS00_01130	COG0594	ribonuclease P activity
HRS00_01135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HRS00_01140	COG2972	Histidine kinase
HRS00_01140	COG0840	transmembrane signaling receptor activity
HRS00_01145	COG1823	symporter activity
HRS00_01160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HRS00_01165	COG0418	dihydroorotase activity
HRS00_01170	COG3938	Belongs to the proline racemase family
HRS00_01180	COG3510	cephalosporin hydroxylase
HRS00_01205	COG0166	Belongs to the GPI family
HRS00_01210	COG0318	PFAM AMP-dependent synthetase and ligase
HRS00_01215	COG3842	ATPase activity
HRS00_01220	COG1840	ABC-type Fe3 transport system, periplasmic component
HRS00_01225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRS00_01240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRS00_01255	COG1595	DNA-templated transcription, initiation
HRS00_01260	COG3806	Anti-sigma factor
HRS00_01275	COG3254	rhamnose metabolic process
HRS00_01285	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_01290	COG1129	ABC transporter
HRS00_01300	COG1349	DNA-binding transcription factor activity
HRS00_01305	COG3347	Dehydrogenase
HRS00_01305	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_01315	COG4952	isomerase
HRS00_01350	COG2326	polyphosphate kinase activity
HRS00_01355	COG5002	protein histidine kinase activity
HRS00_01360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HRS00_01365	COG0573	inorganic phosphate transmembrane transporter activity
HRS00_01375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRS00_01380	COG0704	Plays a role in the regulation of phosphate uptake
HRS00_01385	COG0745	RESPONSE REGULATOR receiver
HRS00_01390	COG1278	Cold shock
HRS00_01410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRS00_01415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRS00_01430	COG2967	ApaG domain
HRS00_01440	COG0717	Belongs to the dCTP deaminase family
HRS00_01450	COG0582	viral genome integration into host DNA
HRS00_01465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRS00_01465	COG0784	Response regulator, receiver
HRS00_01470	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HRS00_01565	COG0167	dihydroorotate dehydrogenase activity
HRS00_01590	COG1201	RNA secondary structure unwinding
HRS00_01605	COG0730	response to heat
HRS00_01615	COG1960	acyl-CoA dehydrogenase activity
HRS00_01620	COG0183	Belongs to the thiolase family
HRS00_01625	COG1024	Enoyl-CoA hydratase
HRS00_01625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRS00_01655	COG1157	protein secretion by the type III secretion system
HRS00_01660	COG4786	Flagellar basal body rod
HRS00_01665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HRS00_01670	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRS00_01675	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRS00_01680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HRS00_01685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRS00_01695	COG0436	Aminotransferase
HRS00_01700	COG1970	mechanosensitive ion channel activity
HRS00_01705	COG2198	Histidine kinase
HRS00_01705	COG0784	Response regulator, receiver
HRS00_01705	COG2205	protein histidine kinase activity
HRS00_01710	COG2972	Histidine kinase
HRS00_01710	COG0840	transmembrane signaling receptor activity
HRS00_01715	COG1320	monovalent cation:proton antiporter activity
HRS00_01720	COG2212	antiporter activity
HRS00_01725	COG1863	multisubunit Na H antiporter MnhE subunit
HRS00_01730	COG0651	ATP synthesis coupled electron transport
HRS00_01735	COG1006	Multisubunit Na H antiporter MnhC subunit
HRS00_01740	COG2111	Na H antiporter
HRS00_01740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRS00_01750	COG0840	transmembrane signaling receptor activity
HRS00_01760	COG0745	RESPONSE REGULATOR receiver
HRS00_01765	COG2198	Histidine kinase
HRS00_01765	COG0643	Histidine kinase
HRS00_01770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRS00_01775	COG2201	protein-glutamate methylesterase activity
HRS00_01780	COG0745	RESPONSE REGULATOR receiver
HRS00_01785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HRS00_01810	COG1766	The M ring may be actively involved in energy transduction
HRS00_01815	COG2771	luxR family
HRS00_01835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRS00_01840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRS00_01845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRS00_01855	COG1360	Flagellar Motor Protein
HRS00_01880	COG1749	Flagellar hook protein flgE
HRS00_01895	COG5442	Flagellar protein FlaF
HRS00_01900	COG5443	negative regulation of bacterial-type flagellum assembly
HRS00_01905	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HRS00_01910	COG4794	Type iii secretion
HRS00_01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HRS00_01945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HRS00_01950	COG5328	Belongs to the UPF0262 family
HRS00_01960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HRS00_01965	COG0424	maF-like protein
HRS00_01970	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HRS00_01980	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HRS00_02010	COG1338	Plays a role in the flagellum-specific transport system
HRS00_02020	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HRS00_02030	COG1706	bacterial-type flagellum-dependent cell motility
HRS00_02035	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HRS00_02040	COG4786	Flagellar basal body rod
HRS00_02045	COG1677	Flagellar hook-basal body complex protein FliE
HRS00_02050	COG1558	bacterial-type flagellum-dependent cell motility
HRS00_02055	COG1815	bacterial-type flagellum-dependent cell motility
HRS00_02065	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HRS00_02070	COG1609	Transcriptional regulator
HRS00_02075	COG1653	transport
HRS00_02080	COG1175	transmembrane transport
HRS00_02085	COG0395	ABC-type sugar transport system, permease component
HRS00_02090	COG0366	Alpha amylase catalytic
HRS00_02095	COG3842	ATPase activity
HRS00_02110	COG0129	dihydroxy-acid dehydratase activity
HRS00_02115	COG0363	glucosamine-6-phosphate deaminase activity
HRS00_02120	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRS00_02125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_02135	COG2081	HI0933 family
HRS00_02155	COG2224	Isocitrate lyase
HRS00_02170	COG3842	ATPase activity
HRS00_02175	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRS00_02180	COG1177	transmembrane transport
HRS00_02195	COG1177	transmembrane transport
HRS00_02200	COG2205	protein histidine kinase activity
HRS00_02215	COG0248	Ppx GppA phosphatase
HRS00_02220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HRS00_02225	COG0477	Major facilitator Superfamily
HRS00_02245	COG0412	Dienelactone hydrolase
HRS00_02250	COG0583	DNA-binding transcription factor activity
HRS00_02270	COG0306	phosphate transporter
HRS00_02280	COG0561	phosphatase activity
HRS00_02285	COG0438	transferase activity, transferring glycosyl groups
HRS00_02290	COG0277	FAD linked oxidase domain protein
HRS00_02295	COG0277	FAD linked oxidase domain protein
HRS00_02300	COG0247	lactate metabolic process
HRS00_02305	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_02310	COG2818	Glycosylase
HRS00_02340	COG0124	histidyl-tRNA synthetase
HRS00_02345	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HRS00_02350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HRS00_02360	COG2259	Doxx family
HRS00_02370	COG0459	protein refolding
HRS00_02375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HRS00_02380	COG2059	Chromate
HRS00_02395	COG0196	riboflavin kinase activity
HRS00_02400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HRS00_02410	COG0590	tRNA wobble adenosine to inosine editing
HRS00_02415	COG1187	pseudouridine synthase activity
HRS00_02420	COG0742	ribosomal rna small subunit methyltransferase
HRS00_02430	COG0312	modulator of DNA gyrase
HRS00_02435	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_02445	COG1519	Transferase
HRS00_02455	COG1663	tetraacyldisaccharide 4'-kinase activity
HRS00_02470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HRS00_02475	COG5002	protein histidine kinase activity
HRS00_02475	COG2198	Histidine kinase
HRS00_02475	COG0784	Response regulator, receiver
HRS00_02480	COG3300	MHYT domain
HRS00_02480	COG5001	Diguanylate cyclase
HRS00_02485	COG3386	PFAM SMP-30 Gluconolaconase
HRS00_02490	COG0800	Aldolase
HRS00_02495	COG3734	2-keto-3-deoxy-galactonokinase
HRS00_02500	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_02510	COG2197	response regulator
HRS00_02520	COG0489	protein tyrosine kinase activity
HRS00_02525	COG0598	Magnesium transport protein CorA
HRS00_02530	COG3158	transport of potassium into the cell
HRS00_02545	COG0356	it plays a direct role in the translocation of protons across the membrane
HRS00_02555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRS00_02560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HRS00_02565	COG0840	transmembrane signaling receptor activity
HRS00_02570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HRS00_02585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HRS00_02590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HRS00_02600	COG0142	geranyltranstransferase activity
HRS00_02615	COG2827	Endonuclease containing a URI domain
HRS00_02635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HRS00_02640	COG1704	LemA family
HRS00_02650	COG0752	glycyl-tRNA synthetase alpha subunit
HRS00_02655	COG0751	glycine-tRNA ligase activity
HRS00_02660	COG1683	Conserved Protein
HRS00_02670	COG0840	transmembrane signaling receptor activity
HRS00_02680	COG0151	Belongs to the GarS family
HRS00_02685	COG2183	response to ionizing radiation
HRS00_02690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HRS00_02710	COG0009	L-threonylcarbamoyladenylate synthase
HRS00_02720	COG4638	Rieske (2fe-2S)
HRS00_02745	COG1960	acyl-CoA dehydrogenase activity
HRS00_02760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HRS00_02770	COG0840	transmembrane signaling receptor activity
HRS00_02775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRS00_02780	COG1741	Belongs to the pirin family
HRS00_02785	COG1722	exodeoxyribonuclease VII activity
HRS00_02790	COG0123	including yeast histone deacetylase and acetoin utilization protein
HRS00_02795	COG1268	BioY protein
HRS00_02800	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HRS00_02805	COG1122	ATPase activity
HRS00_02810	COG3214	Protein conserved in bacteria
HRS00_02820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HRS00_02840	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HRS00_02855	COG0259	pyridoxamine-phosphate oxidase activity
HRS00_02860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRS00_02875	COG0312	modulator of DNA gyrase
HRS00_02890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRS00_02895	COG0109	protoheme IX farnesyltransferase activity
HRS00_02900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HRS00_02915	COG3346	SURF1 family
HRS00_02920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HRS00_02925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HRS00_02930	COG0328	RNA-DNA hybrid ribonuclease activity
HRS00_02940	COG0803	Belongs to the bacterial solute-binding protein 9 family
HRS00_02945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRS00_02950	COG1121	(ABC) transporter
HRS00_02955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRS00_02955	COG0678	peroxiredoxin activity
HRS00_02965	COG1678	Uncharacterized ACR, COG1678
HRS00_02985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRS00_02990	COG0612	Peptidase, M16
HRS00_03015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HRS00_03025	COG1268	BioY protein
HRS00_03040	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HRS00_03050	COG1194	a g-specific adenine glycosylase
HRS00_03060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HRS00_03065	COG1196	nuclear chromosome segregation
HRS00_03070	COG0840	transmembrane signaling receptor activity
HRS00_03075	COG0574	Belongs to the PEP-utilizing enzyme family
HRS00_03075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HRS00_03115	COG0579	oxidoreductase
HRS00_03130	COG1609	Transcriptional regulator
HRS00_03135	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HRS00_03145	COG2895	sulfate adenylyltransferase (ATP) activity
HRS00_03150	COG0175	sulfate reduction
HRS00_03155	COG0175	sulfate reduction
HRS00_03160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HRS00_03165	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HRS00_03170	COG4208	sulfate ABC transporter
HRS00_03175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRS00_03195	COG2203	Gaf domain
HRS00_03195	COG2200	EAL domain
HRS00_03195	COG2199	diguanylate cyclase activity
HRS00_03205	COG1309	transcriptional regulator
HRS00_03210	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_03215	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HRS00_03250	COG3300	MHYT domain
HRS00_03250	COG5001	Diguanylate cyclase
HRS00_03260	COG0477	Major facilitator Superfamily
HRS00_03270	COG1793	dna ligase
HRS00_03280	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_03285	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_03295	COG1846	Transcriptional regulator
HRS00_03300	COG1764	response to oxidative stress
HRS00_03340	COG4221	oxidoreductase activity
HRS00_03350	COG0433	COG0433 Predicted ATPase
HRS00_03360	COG1733	regulation of RNA biosynthetic process
HRS00_03365	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HRS00_03370	COG0656	L-ascorbic acid biosynthetic process
HRS00_03380	COG2378	regulation of single-species biofilm formation
HRS00_03390	COG4106	trans-aconitate 2-methyltransferase activity
HRS00_03410	COG0583	DNA-binding transcription factor activity
HRS00_03425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRS00_03440	COG3909	cytochrome
HRS00_03445	COG2010	Cytochrome c
HRS00_03465	COG0693	protein deglycase activity
HRS00_03470	COG0456	acetyltransferase
HRS00_03485	COG0789	Transcriptional regulator
HRS00_03505	COG0517	IMP dehydrogenase activity
HRS00_03505	COG4175	Glycine betaine
HRS00_03510	COG4176	ABC-type proline glycine betaine transport system permease component
HRS00_03530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_03555	COG2514	catechol 2,3-dioxygenase activity
HRS00_03565	COG1272	protein, Hemolysin III
HRS00_03585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRS00_03590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HRS00_03590	COG2111	Na H antiporter
HRS00_03595	COG2111	Na H antiporter
HRS00_03600	COG1006	Multisubunit Na H antiporter MnhC subunit
HRS00_03605	COG0651	ATP synthesis coupled electron transport
HRS00_03610	COG1863	multisubunit Na H antiporter MnhE subunit
HRS00_03615	COG2212	antiporter activity
HRS00_03620	COG1320	monovalent cation:proton antiporter activity
HRS00_03625	COG4957	zinc ion binding
HRS00_03650	COG2166	iron-sulfur cluster assembly
HRS00_03660	COG2205	protein histidine kinase activity
HRS00_03730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRS00_03735	COG2983	Belongs to the UPF0260 family
HRS00_03795	COG1621	beta-fructofuranosidase activity
HRS00_03805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HRS00_03820	COG2944	sequence-specific DNA binding
HRS00_03855	COG4695	Portal protein
HRS00_04040	COG4235	cytochrome complex assembly
HRS00_04045	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HRS00_04050	COG1138	Cytochrome C-type biogenesis protein
HRS00_04055	COG3088	subunit of a heme lyase
HRS00_04060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HRS00_04075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HRS00_04085	COG1408	metallophosphoesterase
HRS00_04090	COG2202	Pas domain
HRS00_04090	COG2205	protein histidine kinase activity
HRS00_04095	COG0308	aminopeptidase N
HRS00_04100	COG0840	transmembrane signaling receptor activity
HRS00_04100	COG3290	protein histidine kinase activity
HRS00_04125	COG0443	Heat shock 70 kDa protein
HRS00_04145	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_04170	COG1733	regulation of RNA biosynthetic process
HRS00_04175	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_04180	COG1968	undecaprenyl-diphosphatase activity
HRS00_04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_04215	COG2239	Acts as a magnesium transporter
HRS00_04220	COG2814	Major facilitator Superfamily
HRS00_04240	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRS00_04245	COG0463	Glycosyl transferase, family 2
HRS00_04255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HRS00_04295	COG2382	esterase
HRS00_04330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRS00_04375	COG0741	lytic transglycosylase activity
HRS00_04380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_04385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HRS00_04405	COG1758	RNA polymerase activity
HRS00_04425	COG0736	holo-[acyl-carrier-protein] synthase activity
HRS00_04430	COG0681	Belongs to the peptidase S26 family
HRS00_04435	COG0571	ribonuclease III activity
HRS00_04440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HRS00_04445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRS00_04450	COG0784	Response regulator, receiver
HRS00_04455	COG1381	Involved in DNA repair and RecF pathway recombination
HRS00_04470	COG1418	mRNA catabolic process
HRS00_04480	COG0346	lactoylglutathione lyase activity
HRS00_04495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_04500	COG0668	transmembrane transport
HRS00_04510	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HRS00_04535	COG1051	belongs to the nudix hydrolase family
HRS00_04545	COG1742	UPF0060 membrane protein
HRS00_04560	COG1183	phosphatidylcholine synthase activity
HRS00_04565	COG0688	phosphatidylethanolamine metabolic process
HRS00_04570	COG5265	(ABC) transporter
HRS00_04610	COG2852	Protein conserved in bacteria
HRS00_04615	COG0215	cysteine-tRNA ligase activity
HRS00_04620	COG4221	oxidoreductase activity
HRS00_04625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HRS00_04630	COG1286	toxin biosynthetic process
HRS00_04650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRS00_04685	COG0359	binds to the 23S rRNA
HRS00_04695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HRS00_04700	COG0360	Binds together with S18 to 16S ribosomal RNA
HRS00_04705	COG0667	Aldo Keto reductase
HRS00_04710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HRS00_04720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRS00_04725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRS00_04730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HRS00_04735	COG1561	YicC-like family, N-terminal region
HRS00_04740	COG0194	GDP metabolic process
HRS00_04755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HRS00_04760	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRS00_04770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HRS00_04785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HRS00_04810	COG0488	(ABC) transporter
HRS00_04825	COG0105	UTP biosynthetic process
HRS00_04845	COG0314	molybdopterin synthase activity
HRS00_04855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HRS00_04860	COG0322	excinuclease ABC activity
HRS00_04865	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_04875	COG0625	glutathione transferase activity
HRS00_04890	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HRS00_04895	COG0243	molybdopterin cofactor binding
HRS00_04915	COG3609	addiction module antidote protein, CC2985 family
HRS00_04920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HRS00_04925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HRS00_04930	COG0628	permease
HRS00_04940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HRS00_04945	COG0248	Ppx GppA phosphatase
HRS00_04955	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HRS00_04960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HRS00_04965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HRS00_04975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HRS00_04995	COG2382	esterase
HRS00_05000	COG0556	nucleotide-excision repair
HRS00_05050	COG1607	acyl-coa hydrolase
HRS00_05055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRS00_05075	COG0861	Integral membrane protein TerC family
HRS00_05080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRS00_05085	COG1086	Polysaccharide biosynthesis protein
HRS00_05095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HRS00_05105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HRS00_05110	COG0081	regulation of translation
HRS00_05115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HRS00_05120	COG0222	ribosome binding
HRS00_05125	COG0085	RNA polymerase activity
HRS00_05130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HRS00_05155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HRS00_05160	COG0049	tRNA binding
HRS00_05165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HRS00_05170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HRS00_05175	COG0051	transcription antitermination factor activity, RNA binding
HRS00_05180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HRS00_05185	COG0088	Forms part of the polypeptide exit tunnel
HRS00_05190	COG0089	rRNA binding
HRS00_05195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HRS00_05200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HRS00_05205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HRS00_05210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HRS00_05215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HRS00_05220	COG0255	Belongs to the universal ribosomal protein uL29 family
HRS00_05225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HRS00_05230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HRS00_05235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HRS00_05240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HRS00_05245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HRS00_05250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HRS00_05255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HRS00_05260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HRS00_05265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HRS00_05270	COG1841	ribosomal large subunit assembly
HRS00_05275	COG0200	Binds to the 23S rRNA
HRS00_05280	COG0201	protein transport
HRS00_05285	COG0563	adenylate kinase activity
HRS00_05290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HRS00_05295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HRS00_05300	COG0202	RNA polymerase activity
HRS00_05305	COG0203	ribosomal protein L17
HRS00_05320	COG3739	integral membrane protein
HRS00_05330	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HRS00_05335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HRS00_05340	COG0737	Belongs to the 5'-nucleotidase family
HRS00_05360	COG2897	thiosulfate sulfurtransferase activity
HRS00_05375	COG0415	Belongs to the DNA photolyase family
HRS00_05415	COG3932	Exopolysaccharide synthesis, ExoD
HRS00_05420	COG1238	metal cluster binding
HRS00_05505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRS00_05560	COG1612	heme a metabolic process
HRS00_05570	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HRS00_05575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HRS00_05580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HRS00_05590	COG1832	CoA-binding protein
HRS00_05615	COG0405	Gamma-glutamyltransferase
HRS00_05620	COG2199	diguanylate cyclase activity
HRS00_05625	COG0740	serine-type endopeptidase activity
HRS00_05630	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HRS00_05635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HRS00_05650	COG4948	Mandelate Racemase Muconate Lactonizing
HRS00_05655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_05660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRS00_05710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRS00_05715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRS00_05720	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRS00_05730	COG0649	NAD binding
HRS00_05740	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HRS00_05745	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HRS00_05755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HRS00_05760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HRS00_05785	COG1007	ATP synthesis coupled electron transport
HRS00_05800	COG0346	lactoylglutathione lyase activity
HRS00_05810	COG0442	prolyl-tRNA aminoacylation
HRS00_05820	COG1136	(ABC) transporter
HRS00_05840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRS00_05850	COG0784	Response regulator, receiver
HRS00_05860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HRS00_05885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HRS00_05885	COG1754	DNA topoisomerase type I activity
HRS00_05895	COG0758	DNA mediated transformation
HRS00_05895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRS00_05900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HRS00_05910	COG0540	Belongs to the ATCase OTCase family
HRS00_05915	COG1960	acyl-CoA dehydrogenase activity
HRS00_05945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HRS00_05950	COG2824	Alkylphosphonate utilization operon protein PhnA
HRS00_05955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HRS00_05960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRS00_05965	COG0154	amidase activity
HRS00_05970	COG0456	acetyltransferase
HRS00_06030	COG0038	chloride channel
HRS00_06035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRS00_06090	COG0583	DNA-binding transcription factor activity
HRS00_06100	COG0039	L-malate dehydrogenase activity
HRS00_06100	COG0039	L-malate dehydrogenase activity
HRS00_06110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRS00_06145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HRS00_06150	COG2826	transposase and inactivated derivatives, IS30 family
HRS00_06165	COG2826	transposase and inactivated derivatives, IS30 family
HRS00_06170	COG0529	Catalyzes the synthesis of activated sulfate
HRS00_06180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HRS00_06185	COG2199	diguanylate cyclase activity
HRS00_06205	COG0626	cystathionine gamma-synthase activity
HRS00_06210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_06215	COG4597	amino acid ABC transporter
HRS00_06220	COG0765	amino acid transport
HRS00_06225	COG1126	abc transporter atp-binding protein
HRS00_06240	COG0316	Belongs to the HesB IscA family
HRS00_06245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HRS00_06250	COG0018	arginyl-trna synthetase
HRS00_06260	COG1472	Belongs to the glycosyl hydrolase 3 family
HRS00_06265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HRS00_06270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRS00_06275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRS00_06280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HRS00_06285	COG0805	protein transport
HRS00_06290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRS00_06295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HRS00_06300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRS00_06305	COG0739	heme binding
HRS00_06310	COG1763	Mo-molybdopterin cofactor biosynthetic process
HRS00_06315	COG0746	molybdenum cofactor guanylyltransferase activity
HRS00_06320	COG2814	Major facilitator Superfamily
HRS00_06325	COG0697	spore germination
HRS00_06330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HRS00_06340	COG0475	glutathione-regulated potassium exporter activity
HRS00_06340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HRS00_06350	COG3706	GGDEF domain
HRS00_06355	COG0114	fumarate hydratase activity
HRS00_06360	COG2989	Protein conserved in bacteria
HRS00_06365	COG2066	Belongs to the glutaminase family
HRS00_06370	COG0037	tRNA processing
HRS00_06375	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_06380	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_06385	COG2814	Major facilitator Superfamily
HRS00_06390	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HRS00_06395	COG0187	DNA topoisomerase II activity
HRS00_06405	COG0149	triose-phosphate isomerase activity
HRS00_06415	COG0504	CTP synthase activity
HRS00_06425	COG0303	'Molybdopterin
HRS00_06430	COG0315	cyclic pyranopterin monophosphate synthase activity
HRS00_06435	COG0134	indole-3-glycerol-phosphate synthase activity
HRS00_06440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HRS00_06455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HRS00_06470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HRS00_06475	COG0343	queuine tRNA-ribosyltransferase activity
HRS00_06480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRS00_06490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HRS00_06495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRS00_06500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRS00_06505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRS00_06510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HRS00_06545	COG0436	Aminotransferase
HRS00_06605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HRS00_06610	COG1609	Transcriptional regulator
HRS00_06620	COG0667	Aldo Keto reductase
HRS00_06630	COG0523	cobalamin synthesis protein
HRS00_06640	COG1121	(ABC) transporter
HRS00_06645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRS00_06665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HRS00_06675	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HRS00_06680	COG0629	single-stranded DNA binding
HRS00_06695	COG2095	MarC family integral membrane protein
HRS00_06710	COG1686	Belongs to the peptidase S11 family
HRS00_06760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HRS00_06770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRS00_06775	COG0084	hydrolase, TatD family'
HRS00_06780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HRS00_06780	COG0321	lipoyl(octanoyl) transferase activity
HRS00_06785	COG0038	chloride channel
HRS00_06795	COG2801	Transposase and inactivated derivatives
HRS00_06805	COG1671	Belongs to the UPF0178 family
HRS00_06815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRS00_06830	COG0546	phosphoglycolate phosphatase activity
HRS00_06835	COG0564	pseudouridine synthase activity
HRS00_06840	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRS00_06865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRS00_06870	COG0509	glycine decarboxylation via glycine cleavage system
HRS00_06875	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRS00_06875	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HRS00_06910	COG1648	precorrin-2 dehydrogenase activity
HRS00_06910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HRS00_06920	COG3956	TIGRFAM MazG family protein
HRS00_06930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HRS00_06935	COG1923	regulation of RNA biosynthetic process
HRS00_06940	COG0569	domain protein
HRS00_06945	COG2204	response regulator
HRS00_06950	COG5000	phosphorelay sensor kinase activity
HRS00_06955	COG2204	response regulator
HRS00_06960	COG3852	Histidine kinase
HRS00_06970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HRS00_06970	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HRS00_06975	COG1546	Belongs to the CinA family
HRS00_06975	COG1058	Belongs to the CinA family
HRS00_06980	COG2867	negative regulation of translational initiation
HRS00_06995	COG2207	Transcriptional regulator
HRS00_07000	COG0697	spore germination
HRS00_07005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HRS00_07020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HRS00_07030	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRS00_07040	COG0022	dehydrogenase e1 component
HRS00_07040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRS00_07045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HRS00_07055	COG0148	phosphopyruvate hydratase activity
HRS00_07060	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HRS00_07065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HRS00_07095	COG0765	amino acid transport
HRS00_07100	COG0765	amino acid transport
HRS00_07110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRS00_07115	COG3494	Protein of unknown function (DUF1009)
HRS00_07120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRS00_07125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HRS00_07130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HRS00_07135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRS00_07140	COG0750	zinc metalloprotease
HRS00_07150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HRS00_07155	COG0233	cytoplasmic translational termination
HRS00_07160	COG0528	UMP kinase activity
HRS00_07165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HRS00_07170	COG0052	Belongs to the universal ribosomal protein uS2 family
HRS00_07220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HRS00_07245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HRS00_07250	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HRS00_07255	COG0511	ligase activity, forming carbon-carbon bonds
HRS00_07260	COG0439	Biotin carboxylase
HRS00_07265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HRS00_07290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HRS00_07300	COG0456	acetyltransferase
HRS00_07325	COG2239	Acts as a magnesium transporter
HRS00_07330	COG0243	molybdopterin cofactor binding
HRS00_07340	COG0242	peptide deformylase activity
HRS00_07355	COG0823	Involved in the tonB-independent uptake of proteins
HRS00_07370	COG1368	sulfuric ester hydrolase activity
HRS00_07390	COG0544	peptidyl-prolyl cis-trans isomerase activity
HRS00_07425	COG0384	phenazine biosynthesis protein PhzF
HRS00_07430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HRS00_07450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRS00_07455	COG0860	N-Acetylmuramoyl-L-alanine amidase
HRS00_07460	COG1530	ribonuclease E activity
HRS00_07465	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HRS00_07480	COG3106	COG3106 Predicted ATPase
HRS00_07485	COG3768	UPF0283 membrane protein
HRS00_07495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HRS00_07500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HRS00_07505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HRS00_07515	COG0633	Ferredoxin
HRS00_07535	COG3218	ABC-type transport auxiliary lipoprotein component
HRS00_07535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HRS00_07545	COG1127	ABC transporter
HRS00_07550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HRS00_07555	COG4948	Mandelate Racemase Muconate Lactonizing
HRS00_07565	COG0280	phosphate acetyltransferase
HRS00_07565	COG0281	malic enzyme
HRS00_07575	COG0778	Nitroreductase
HRS00_07585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HRS00_07595	COG0745	RESPONSE REGULATOR receiver
HRS00_07600	COG4191	Histidine kinase
HRS00_07600	COG0784	Response regulator, receiver
HRS00_07605	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_07610	COG0436	Aminotransferase
HRS00_07630	COG3243	poly(R)-hydroxyalkanoic acid synthase
HRS00_07635	COG1489	DNA binding
HRS00_07640	COG0024	Methionine aminopeptidase
HRS00_07645	COG2003	Belongs to the UPF0758 family
HRS00_07660	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HRS00_07675	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HRS00_07680	COG0546	phosphoglycolate phosphatase activity
HRS00_07685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HRS00_07690	COG0861	Integral membrane protein TerC family
HRS00_07710	COG1280	lysine exporter protein (LysE YggA)
HRS00_07720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HRS00_07725	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HRS00_07735	COG0538	isocitrate dehydrogenase activity
HRS00_07745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HRS00_07750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HRS00_07755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRS00_07760	COG2313	pseudouridylate synthase activity
HRS00_07770	COG5425	PFAM Usg family protein
HRS00_07795	COG1522	sequence-specific DNA binding
HRS00_07800	COG1573	uracil-dna glycosylase
HRS00_07810	COG2202	Pas domain
HRS00_07810	COG2205	protein histidine kinase activity
HRS00_07820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HRS00_07825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HRS00_07850	COG0525	valine-tRNA ligase activity
HRS00_07880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HRS00_07880	COG3264	Mechanosensitive ion channel
HRS00_07895	COG2067	long-chain fatty acid transport protein
HRS00_07900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HRS00_07915	COG3737	Protein of unknown function (DUF498/DUF598)
HRS00_07925	COG1862	Preprotein translocase
HRS00_07945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HRS00_07950	COG0739	heme binding
HRS00_07955	COG0513	Belongs to the DEAD box helicase family
HRS00_07975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRS00_07995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRS00_08000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRS00_08005	COG0047	phosphoribosylformylglycinamidine synthase activity
HRS00_08020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRS00_08025	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HRS00_08050	COG0321	lipoyl(octanoyl) transferase activity
HRS00_08055	COG1064	alcohol dehydrogenase
HRS00_08065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HRS00_08095	COG1546	Belongs to the CinA family
HRS00_08095	COG1058	Belongs to the CinA family
HRS00_08100	COG0589	response to stress
HRS00_08105	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HRS00_08110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HRS00_08115	COG0842	Transport permease protein
HRS00_08120	COG1131	(ABC) transporter
HRS00_08140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HRS00_08170	COG0129	dihydroxy-acid dehydratase activity
HRS00_08175	COG0583	DNA-binding transcription factor activity
HRS00_08180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HRS00_08190	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HRS00_08195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HRS00_08220	COG0776	regulation of translation
HRS00_08225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HRS00_08230	COG0416	fatty acid biosynthetic process
HRS00_08250	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HRS00_08255	COG2814	Major facilitator Superfamily
HRS00_08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HRS00_08265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HRS00_08275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRS00_08275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRS00_08280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HRS00_08285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HRS00_08305	COG0113	porphobilinogen synthase activity
HRS00_08315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HRS00_08325	COG0484	heat shock protein binding
HRS00_08405	COG1525	nuclease
HRS00_08515	COG0616	signal peptide processing
HRS00_08520	COG4695	Portal protein
HRS00_08630	COG4149	molybdate abc transporter
HRS00_08640	COG0384	phenazine biosynthesis protein PhzF
HRS00_08645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HRS00_08660	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HRS00_08670	COG1733	regulation of RNA biosynthetic process
HRS00_08675	COG0702	epimerase
HRS00_08690	COG2267	carboxylic ester hydrolase activity
HRS00_08695	COG1045	serine acetyltransferase
HRS00_08720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HRS00_08740	COG2827	Endonuclease containing a URI domain
HRS00_08745	COG1132	(ABC) transporter
HRS00_08750	COG0628	permease
HRS00_08790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HRS00_08795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HRS00_08805	COG0302	gtp cyclohydrolase
HRS00_08810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HRS00_08815	COG1752	Esterase of the alpha-beta hydrolase superfamily
HRS00_08820	COG0516	GMP reductase activity
HRS00_08820	COG0517	IMP dehydrogenase activity
HRS00_08850	COG1760	l-serine dehydratase
HRS00_08870	COG0583	DNA-binding transcription factor activity
HRS00_08885	COG0745	RESPONSE REGULATOR receiver
HRS00_08895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HRS00_08895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HRS00_08900	COG0347	Belongs to the P(II) protein family
HRS00_08905	COG0174	glutamine synthetase
HRS00_08935	COG0697	spore germination
HRS00_08945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HRS00_08955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HRS00_08980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRS00_08985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HRS00_09000	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRS00_09005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_09010	COG3845	ABC transporter
HRS00_09015	COG1183	phosphatidylcholine synthase activity
HRS00_09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRS00_09025	COG0679	Auxin Efflux Carrier
HRS00_09030	COG0785	Cytochrome C biogenesis protein
HRS00_09050	COG0346	lactoylglutathione lyase activity
HRS00_09055	COG1278	Cold shock
HRS00_09100	COG0443	Heat shock 70 kDa protein
HRS00_09140	COG0840	transmembrane signaling receptor activity
HRS00_09150	COG1136	(ABC) transporter
HRS00_09150	COG0577	efflux transmembrane transporter activity
HRS00_09155	COG1136	(ABC) transporter
HRS00_09155	COG0577	efflux transmembrane transporter activity
HRS00_09160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRS00_09175	COG0316	Belongs to the HesB IscA family
HRS00_09180	COG2151	metal-sulfur cluster biosynthetic enzyme
HRS00_09185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRS00_09190	COG0719	Fe-S assembly protein
HRS00_09195	COG0396	ATPase activity
HRS00_09200	COG2827	Endonuclease containing a URI domain
HRS00_09205	COG0719	Fe-S assembly protein
HRS00_09210	COG1104	cysteine desulfurase activity
HRS00_09215	COG2945	thiolester hydrolase activity
HRS00_09220	COG1252	NADH dehydrogenase
HRS00_09225	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HRS00_09235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRS00_09240	COG2972	Histidine kinase
HRS00_09240	COG0840	transmembrane signaling receptor activity
HRS00_09245	COG1280	lysine exporter protein (LysE YggA)
HRS00_09250	COG0656	L-ascorbic acid biosynthetic process
HRS00_09255	COG0840	transmembrane signaling receptor activity
HRS00_09270	COG0440	acetolactate synthase activity
HRS00_09275	COG0028	Belongs to the TPP enzyme family
HRS00_09285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HRS00_09290	COG3830	Belongs to the UPF0237 family
HRS00_09290	COG0560	Phosphoserine phosphatase
HRS00_09300	COG1116	anion transmembrane transporter activity
HRS00_09315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_09340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HRS00_09350	COG0330	HflC and HflK could
HRS00_09355	COG0330	HflC and HflK could
HRS00_09380	COG0277	FAD linked oxidase domain protein
HRS00_09385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRS00_09390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRS00_09420	COG1335	isochorismatase
HRS00_09450	COG2264	protein methyltransferase activity
HRS00_09465	COG0835	chemotaxis
HRS00_09475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRS00_09480	COG0697	spore germination
HRS00_09485	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HRS00_09490	COG1280	lysine exporter protein (LysE YggA)
HRS00_09495	COG0497	DNA recombination
HRS00_09500	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HRS00_09510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HRS00_09515	COG0849	cell division
HRS00_09520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HRS00_09525	COG1181	Belongs to the D-alanine--D-alanine ligase family
HRS00_09535	COG0477	Major facilitator Superfamily
HRS00_09545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HRS00_09550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HRS00_09555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRS00_09565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HRS00_09570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HRS00_09580	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HRS00_09595	COG0275	rRNA processing
HRS00_09600	COG2001	Belongs to the MraZ family
HRS00_09610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_09625	COG3023	N-Acetylmuramoyl-L-alanine amidase
HRS00_09675	COG2226	methyltransferase
HRS00_09690	COG0840	transmembrane signaling receptor activity
HRS00_09700	COG2267	carboxylic ester hydrolase activity
HRS00_09705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRS00_09725	COG0251	oxidation-reduction process
HRS00_09740	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_09745	COG2814	Major facilitator Superfamily
HRS00_09750	COG1309	transcriptional regulator
HRS00_09775	COG0531	amino acid
HRS00_09785	COG1737	Transcriptional regulator
HRS00_09795	COG1178	ABC-type Fe3 transport system permease component
HRS00_09805	COG3842	ATPase activity
HRS00_09855	COG2968	Membrane
HRS00_09865	COG0432	Pfam Uncharacterised protein family UPF0047
HRS00_09880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRS00_09885	COG0358	DNA primase activity
HRS00_09905	COG0505	Belongs to the CarA family
HRS00_09910	COG0534	Mate efflux family protein
HRS00_09925	COG2321	neutral zinc metallopeptidase
HRS00_09935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HRS00_09945	COG1573	uracil-dna glycosylase
HRS00_09955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HRS00_09960	COG0438	transferase activity, transferring glycosyl groups
HRS00_09965	COG0438	transferase activity, transferring glycosyl groups
HRS00_09970	COG0463	Glycosyl transferase, family 2
HRS00_09980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRS00_10020	COG1522	sequence-specific DNA binding
HRS00_10025	COG0492	ferredoxin-NADP+ reductase activity
HRS00_10030	COG0583	DNA-binding transcription factor activity
HRS00_10045	COG1902	pentaerythritol trinitrate reductase activity
HRS00_10065	COG0387	Pfam Sodium calcium exchanger
HRS00_10085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HRS00_10095	COG1278	Cold shock
HRS00_10100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRS00_10110	COG1846	Transcriptional regulator
HRS00_10115	COG0745	RESPONSE REGULATOR receiver
HRS00_10120	COG2205	protein histidine kinase activity
HRS00_10125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRS00_10145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HRS00_10155	COG1496	oxidoreductase activity
HRS00_10170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HRS00_10180	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_10190	COG5001	Diguanylate cyclase
HRS00_10190	COG3300	MHYT domain
HRS00_10195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HRS00_10200	COG5001	Diguanylate cyclase
HRS00_10200	COG3300	MHYT domain
HRS00_10210	COG0193	aminoacyl-tRNA hydrolase activity
HRS00_10240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRS00_10255	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HRS00_10255	COG2857	Cytochrome c1
HRS00_10275	COG1132	(ABC) transporter
HRS00_10280	COG1132	(ABC) transporter
HRS00_10285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HRS00_10300	COG0408	coproporphyrinogen oxidase activity
HRS00_10315	COG0617	tRNA 3'-terminal CCA addition
HRS00_10330	COG0714	Associated with various cellular activities
HRS00_10350	COG0454	-acetyltransferase
HRS00_10365	COG0435	Glutathione S-transferase
HRS00_10385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HRS00_10400	COG3135	benzoate transporter
HRS00_10410	COG1733	regulation of RNA biosynthetic process
HRS00_10420	COG0740	serine-type endopeptidase activity
HRS00_10435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HRS00_10440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HRS00_10455	COG0512	Glutamine amidotransferase of anthranilate synthase
HRS00_10455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HRS00_10475	COG2197	response regulator
HRS00_10495	COG1435	thymidine kinase activity
HRS00_10510	COG4175	Glycine betaine
HRS00_10530	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HRS00_10540	COG0366	Alpha amylase catalytic
HRS00_10545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRS00_10560	COG0494	nUDIX hydrolase
HRS00_10565	COG1160	GTP binding
HRS00_10585	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HRS00_10590	COG0024	Methionine aminopeptidase
HRS00_10605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRS00_10610	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_10630	COG0583	DNA-binding transcription factor activity
HRS00_10640	COG0402	S-adenosylhomocysteine deaminase activity
HRS00_10645	COG0840	transmembrane signaling receptor activity
HRS00_10655	COG1304	FMN binding
HRS00_10660	COG1686	Belongs to the peptidase S11 family
HRS00_10670	COG2351	hydroxyisourate hydrolase activity
HRS00_10675	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRS00_10705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_10710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_10710	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HRS00_10715	COG0513	Belongs to the DEAD box helicase family
HRS00_10720	COG0784	Response regulator, receiver
HRS00_10720	COG2205	protein histidine kinase activity
HRS00_10720	COG5002	protein histidine kinase activity
HRS00_10725	COG2259	Doxx family
HRS00_10740	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_10745	COG2308	Evidence 4 Homologs of previously reported genes of
HRS00_10755	COG1305	Transglutaminase-like
HRS00_10770	COG4214	carbohydrate transport
HRS00_10780	COG4213	ABC transporter substrate-binding protein
HRS00_10805	COG4213	ABC transporter substrate-binding protein
HRS00_10810	COG4214	carbohydrate transport
HRS00_10815	COG1129	ABC transporter
HRS00_10840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRS00_10855	COG1595	DNA-templated transcription, initiation
HRS00_10900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRS00_10905	COG2346	COG2346, Truncated hemoglobins
HRS00_10920	COG1309	transcriptional regulator
HRS00_10940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_10945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_10970	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HRS00_10975	COG0830	nickel cation binding
HRS00_10980	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HRS00_10995	COG0804	urea catabolic process
HRS00_11000	COG3755	Protein conserved in bacteria
HRS00_11005	COG0832	Belongs to the urease beta subunit family
HRS00_11010	COG3813	Protein conserved in bacteria
HRS00_11015	COG0831	urea catabolic process
HRS00_11020	COG0829	nickel cation binding
HRS00_11040	COG0411	ABC transporter
HRS00_11050	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRS00_11065	COG0174	glutamine synthetase
HRS00_11070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_11070	COG2205	protein histidine kinase activity
HRS00_11075	COG0745	RESPONSE REGULATOR receiver
HRS00_11090	COG0726	polysaccharide deacetylase
HRS00_11125	COG1218	3'(2'),5'-bisphosphate nucleotidase
HRS00_11150	COG0519	Catalyzes the synthesis of GMP from XMP
HRS00_11180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HRS00_11190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HRS00_11200	COG0564	pseudouridine synthase activity
HRS00_11210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HRS00_11225	COG0346	lactoylglutathione lyase activity
HRS00_11240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HRS00_11245	COG0346	lactoylglutathione lyase activity
HRS00_11250	COG2832	Protein of unknown function (DUF454)
HRS00_11255	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HRS00_11260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_11265	COG4558	Periplasmic binding protein
HRS00_11275	COG3721	Heme iron utilization protein
HRS00_11325	COG0783	Belongs to the Dps family
HRS00_11345	COG2202	Pas domain
HRS00_11345	COG3920	Histidine kinase
HRS00_11360	COG0753	catalase activity
HRS00_11375	COG0438	transferase activity, transferring glycosyl groups
HRS00_11380	COG0438	transferase activity, transferring glycosyl groups
HRS00_11390	COG0482	sulfurtransferase activity
HRS00_11405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRS00_11420	COG3300	MHYT domain
HRS00_11420	COG5001	Diguanylate cyclase
HRS00_11425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HRS00_11430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HRS00_11435	COG0037	tRNA processing
HRS00_11445	COG2885	chlorophyll binding
HRS00_11450	COG0823	Involved in the tonB-independent uptake of proteins
HRS00_11470	COG0824	Thioesterase
HRS00_11495	COG1408	metallophosphoesterase
HRS00_11500	COG2255	four-way junction helicase activity
HRS00_11515	COG0632	four-way junction helicase activity
HRS00_11520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HRS00_11525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_11530	COG0563	adenylate kinase activity
HRS00_11535	COG0217	transcriptional regulatory protein
HRS00_11550	COG1692	metallophosphoesterase
HRS00_11560	COG1253	flavin adenine dinucleotide binding
HRS00_11605	COG0126	phosphoglycerate kinase activity
HRS00_11610	COG3588	fructose-bisphosphate aldolase
HRS00_11620	COG1132	(ABC) transporter
HRS00_11625	COG0254	rRNA binding
HRS00_11660	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_11690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HRS00_11695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HRS00_11700	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HRS00_11720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRS00_11725	COG2951	lytic endotransglycosylase activity
HRS00_11750	COG1487	ribonuclease activity
HRS00_11760	COG0070	glutamate synthase
HRS00_11760	COG0069	glutamate synthase activity
HRS00_11760	COG0067	glutamate synthase
HRS00_11780	COG0071	Belongs to the small heat shock protein (HSP20) family
HRS00_11810	COG3750	Belongs to the UPF0335 family
HRS00_11815	COG3750	Belongs to the UPF0335 family
HRS00_11820	COG3750	Belongs to the UPF0335 family
HRS00_11840	COG0469	pyruvate kinase activity
HRS00_11850	COG3108	Peptidase M15
HRS00_11865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HRS00_11875	COG5310	Homospermidine synthase
HRS00_11885	COG0737	Belongs to the 5'-nucleotidase family
HRS00_11890	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HRS00_11895	COG0330	HflC and HflK could
HRS00_11950	COG2308	Evidence 4 Homologs of previously reported genes of
HRS00_11950	COG2307	Protein conserved in bacteria
HRS00_11965	COG0058	SHG alpha-glucan phosphorylase activity
HRS00_11970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRS00_11975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HRS00_11980	COG0297	glycogen (starch) synthase activity
HRS00_11985	COG0033	Phosphoglucomutase
HRS00_11990	COG1523	belongs to the glycosyl hydrolase 13 family
HRS00_12000	COG0531	amino acid
HRS00_12020	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRS00_12020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRS00_12035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_12040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRS00_12055	COG1132	(ABC) transporter
HRS00_12065	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRS00_12075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HRS00_12080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HRS00_12085	COG2972	Histidine kinase
HRS00_12085	COG0840	transmembrane signaling receptor activity
HRS00_12090	COG3047	cAMP biosynthetic process
HRS00_12110	COG0523	cobalamin synthesis protein
HRS00_12120	COG1846	Transcriptional regulator
HRS00_12125	COG1609	Transcriptional regulator
HRS00_12130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRS00_12145	COG0583	DNA-binding transcription factor activity
HRS00_12155	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HRS00_12185	COG1566	PFAM secretion protein HlyD family protein
HRS00_12195	COG1253	flavin adenine dinucleotide binding
HRS00_12200	COG0471	metal ion transport
HRS00_12200	COG3273	potassium ion transport
HRS00_12205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRS00_12210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HRS00_12215	COG1054	Belongs to the UPF0176 family
HRS00_12230	COG0800	Aldolase
HRS00_12240	COG1609	Transcriptional regulator
HRS00_12245	COG1070	Carbohydrate kinase
HRS00_12250	COG2115	Belongs to the xylose isomerase family
HRS00_12255	COG0778	Nitroreductase
HRS00_12260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HRS00_12265	COG2011	ABC-type metal ion transport system permease component
HRS00_12275	COG5001	Diguanylate cyclase
HRS00_12290	COG1121	(ABC) transporter
HRS00_12295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRS00_12300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HRS00_12310	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_12315	COG1414	Transcriptional regulator
HRS00_12320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HRS00_12340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HRS00_12365	COG1069	ribulokinase activity
HRS00_12385	COG0395	ABC-type sugar transport system, permease component
HRS00_12390	COG1175	transmembrane transport
HRS00_12400	COG2390	Transcriptional regulator
HRS00_12410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_12420	COG0747	negative chemotaxis
HRS00_12430	COG4608	Belongs to the ABC transporter superfamily
HRS00_12435	COG0444	Belongs to the ABC transporter superfamily
HRS00_12440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_12445	COG0601	transmembrane transport
HRS00_12450	COG0747	negative chemotaxis
HRS00_12460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HRS00_12465	COG1473	amidohydrolase
HRS00_12470	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HRS00_12490	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRS00_12500	COG1609	Transcriptional regulator
HRS00_12505	COG0583	DNA-binding transcription factor activity
HRS00_12510	COG1960	acyl-CoA dehydrogenase activity
HRS00_12525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HRS00_12530	COG4208	sulfate ABC transporter
HRS00_12540	COG4150	thiosulfate binding
HRS00_12545	COG1024	Enoyl-CoA hydratase
HRS00_12560	COG0019	diaminopimelate decarboxylase activity
HRS00_12575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HRS00_12580	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRS00_12600	COG0395	ABC-type sugar transport system, permease component
HRS00_12605	COG1175	transmembrane transport
HRS00_12630	COG0784	Response regulator, receiver
HRS00_12645	COG1522	sequence-specific DNA binding
HRS00_12655	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_12660	COG0583	DNA-binding transcription factor activity
HRS00_12670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HRS00_12675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRS00_12695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_12710	COG4993	Dehydrogenase
HRS00_12715	COG0252	asparaginase activity
HRS00_12730	COG2186	Transcriptional regulator
HRS00_12735	COG3707	response regulator
HRS00_12740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRS00_12745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HRS00_12750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_12755	COG1116	anion transmembrane transporter activity
HRS00_12760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HRS00_12770	COG0243	molybdopterin cofactor binding
HRS00_12820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HRS00_12835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRS00_12845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HRS00_12850	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HRS00_12855	COG1509	lysine 2,3-aminomutase activity
HRS00_12870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_12880	COG0725	ABC transporter, periplasmic molybdate-binding protein
HRS00_12885	COG4149	molybdate abc transporter
HRS00_12890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HRS00_12905	COG2022	thiamine diphosphate biosynthetic process
HRS00_12920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HRS00_12925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HRS00_12935	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HRS00_12950	COG1132	(ABC) transporter
HRS00_12955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HRS00_12960	COG1234	tRNA 3'-trailer cleavage
HRS00_13000	COG0747	negative chemotaxis
HRS00_13010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_13025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HRS00_13030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRS00_13035	COG0671	phosphoesterase, PA-phosphatase related
HRS00_13040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HRS00_13045	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRS00_13050	COG0156	8-amino-7-oxononanoate synthase activity
HRS00_13075	COG0835	chemotaxis
HRS00_13085	COG2223	nitrite transmembrane transporter activity
HRS00_13090	COG4191	Histidine kinase
HRS00_13095	COG2204	response regulator
HRS00_13100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HRS00_13105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HRS00_13110	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HRS00_13115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HRS00_13120	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HRS00_13125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HRS00_13140	COG4974	Belongs to the 'phage' integrase family
HRS00_13160	COG1280	lysine exporter protein (LysE YggA)
HRS00_13170	COG0508	dehydrogenase complex catalyzes the overall conversion of
HRS00_13180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HRS00_13185	COG0045	succinate-CoA ligase (ADP-forming) activity
HRS00_13190	COG0039	L-malate dehydrogenase activity
HRS00_13195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HRS00_13225	COG2264	protein methyltransferase activity
HRS00_13240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HRS00_13245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HRS00_13250	COG0181	hydroxymethylbilane synthase activity
HRS00_13280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HRS00_13305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HRS00_13310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HRS00_13315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRS00_13320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HRS00_13325	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HRS00_13330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HRS00_13335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HRS00_13340	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HRS00_13345	COG0799	negative regulation of ribosome biogenesis
HRS00_13350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HRS00_13360	COG0793	Belongs to the peptidase S41A family
HRS00_13370	COG0494	nUDIX hydrolase
HRS00_13385	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_13395	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HRS00_13400	COG2270	Major facilitator Superfamily
HRS00_13405	COG2902	Dehydrogenase
HRS00_13410	COG1329	Transcriptional regulator
HRS00_13420	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRS00_13440	COG0488	(ABC) transporter
HRS00_13450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HRS00_13460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HRS00_13465	COG0142	geranyltranstransferase activity
HRS00_13470	COG1349	DNA-binding transcription factor activity
HRS00_13475	COG2223	nitrite transmembrane transporter activity
HRS00_13480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HRS00_13485	COG2885	chlorophyll binding
HRS00_13490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HRS00_13495	COG2197	response regulator
HRS00_13500	COG1132	(ABC) transporter
HRS00_13510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HRS00_13515	COG2084	Dehydrogenase
HRS00_13535	COG1473	amidohydrolase
HRS00_13540	COG3459	Glycosyltransferase 36 associated
HRS00_13545	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HRS00_13550	COG0495	leucyl-tRNA aminoacylation
HRS00_13565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HRS00_13580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRS00_13585	COG1946	Acyl-CoA thioesterase
HRS00_13590	COG0347	Belongs to the P(II) protein family
HRS00_13595	COG0004	ammonium transporteR
HRS00_13600	COG1674	ftsk spoiiie
HRS00_13605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HRS00_13625	COG0745	RESPONSE REGULATOR receiver
HRS00_13635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRS00_13645	COG0765	amino acid transport
HRS00_13650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_13655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HRS00_13660	COG4120	Belongs to the binding-protein-dependent transport system permease family
HRS00_13670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HRS00_13685	COG2154	pterin-4-alpha-carbinolamine dehydratase
HRS00_13690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HRS00_13695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HRS00_13705	COG4181	ATPase activity
HRS00_13710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HRS00_13715	COG0670	Belongs to the BI1 family
HRS00_13730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRS00_13735	COG4133	protoheme IX ABC transporter activity
HRS00_13740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRS00_13745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HRS00_13765	COG2917	probably involved in intracellular septation
HRS00_13770	COG0552	protein localization to endoplasmic reticulum
HRS00_13775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HRS00_13780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HRS00_13795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HRS00_13800	COG1605	Chorismate mutase
HRS00_13800	COG0287	Prephenate dehydrogenase
HRS00_13805	COG0228	four-way junction DNA binding
HRS00_13810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HRS00_13815	COG0336	Belongs to the RNA methyltransferase TrmD family
HRS00_13825	COG0335	large ribosomal subunit rRNA binding
HRS00_13830	COG1280	lysine exporter protein (LysE YggA)
HRS00_13840	COG0137	argininosuccinate synthase activity
HRS00_13845	COG2814	Major facilitator Superfamily
HRS00_13855	COG0339	signal peptide processing
HRS00_13860	COG1217	gtp-binding protein TYPA
HRS00_13870	COG0066	3-isopropylmalate dehydratase activity
HRS00_13875	COG0473	3-isopropylmalate dehydrogenase activity
HRS00_13880	COG1858	cytochrome C peroxidase
HRS00_13890	COG0625	glutathione transferase activity
HRS00_13895	COG1797	cobyrinic acid a,c-diamide synthase activity
HRS00_13900	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HRS00_13965	COG1492	cobalamin metabolic process
HRS00_13980	COG4948	Mandelate Racemase Muconate Lactonizing
HRS00_13985	COG1063	alcohol dehydrogenase
HRS00_14005	COG4214	carbohydrate transport
HRS00_14010	COG1129	ABC transporter
HRS00_14015	COG2186	Transcriptional regulator
HRS00_14020	COG2721	sulfolactate sulfo-lyase activity
HRS00_14025	COG0138	bifunctional purine biosynthesis protein purh
HRS00_14035	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HRS00_14040	COG0501	Belongs to the peptidase M48B family
HRS00_14060	COG0357	Ribosomal RNA small subunit methyltransferase G
HRS00_14065	COG0445	tRNA wobble uridine modification
HRS00_14070	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HRS00_14075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HRS00_14080	COG1981	membrane
HRS00_14085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HRS00_14090	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HRS00_14095	COG0424	maF-like protein
HRS00_14100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRS00_14105	COG0237	dephospho-CoA kinase activity
HRS00_14110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRS00_14115	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HRS00_14120	COG3030	protein affecting phage T7 exclusion by the F plasmid
HRS00_14155	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRS00_14170	COG0135	phosphoribosylanthranilate isomerase activity
HRS00_14175	COG0133	tryptophan synthase activity
HRS00_14180	COG0159	tryptophan synthase activity
HRS00_14185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HRS00_14190	COG0285	dihydrofolate synthase activity
HRS00_14210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HRS00_14215	COG3178	'Phosphotransferase
HRS00_14220	COG2205	protein histidine kinase activity
HRS00_14225	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HRS00_14230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRS00_14235	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HRS00_14235	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HRS00_14240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HRS00_14245	COG0642	Histidine kinase
HRS00_14250	COG0745	RESPONSE REGULATOR receiver
HRS00_14255	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HRS00_14265	COG1072	(Pantothenic acid kinase))
HRS00_14270	COG0140	phosphoribosyl-ATP diphosphatase activity
HRS00_14275	COG0107	imidazoleglycerol-phosphate synthase activity
HRS00_14280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HRS00_14285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HRS00_14295	COG0131	Imidazoleglycerol-phosphate dehydratase
HRS00_14300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HRS00_14305	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HRS00_14315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HRS00_14330	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HRS00_14340	COG1643	Atp-dependent helicase
HRS00_14345	COG2423	ornithine cyclodeaminase activity
HRS00_14380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HRS00_14385	COG0406	alpha-ribazole phosphatase activity
HRS00_14400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HRS00_14405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HRS00_14410	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HRS00_14415	COG0295	cytidine deaminase activity
HRS00_14420	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRS00_14425	COG1079	Belongs to the binding-protein-dependent transport system permease family
HRS00_14430	COG3845	ABC transporter
HRS00_14435	COG1744	ABC transporter substrate-binding protein PnrA-like
HRS00_14440	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HRS00_14475	COG1072	(Pantothenic acid kinase))
HRS00_14480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HRS00_14505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRS00_14520	COG1185	polyribonucleotide nucleotidyltransferase activity
HRS00_14525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HRS00_14530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HRS00_14535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HRS00_14540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HRS00_14540	COG3064	Membrane
HRS00_14555	COG0779	Required for maturation of 30S ribosomal subunits
HRS00_14560	COG2814	Major facilitator Superfamily
HRS00_14565	COG0784	Response regulator, receiver
HRS00_14565	COG4191	Histidine kinase
HRS00_14575	COG1136	(ABC) transporter
HRS00_14585	COG1785	Belongs to the alkaline phosphatase family
HRS00_14590	COG0443	Heat shock 70 kDa protein
HRS00_14595	COG0484	heat shock protein binding
HRS00_14610	COG2900	Belongs to the SlyX family
HRS00_14640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HRS00_14650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRS00_14650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRS00_14660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRS00_14665	COG1278	Cold shock
HRS00_14670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HRS00_14675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HRS00_14680	COG3474	cytochrome
HRS00_14685	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HRS00_14690	COG1605	Chorismate mutase
HRS00_14690	COG0077	Prephenate dehydratase
HRS00_14695	COG2816	NAD+ diphosphatase activity
HRS00_14710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HRS00_14715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HRS00_14725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HRS00_14730	COG2951	lytic endotransglycosylase activity
HRS00_14735	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HRS00_14740	COG2226	methyltransferase
HRS00_14745	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HRS00_14750	COG1024	Enoyl-CoA hydratase
HRS00_14755	COG0268	Binds directly to 16S ribosomal RNA
HRS00_14785	COG0328	RNA-DNA hybrid ribonuclease activity
HRS00_14815	COG4297	protein containing double-stranded beta helix domain
HRS00_14830	COG3754	Rhamnan synthesis protein F
HRS00_14855	COG0463	Glycosyl transferase, family 2
HRS00_14860	COG2801	Transposase and inactivated derivatives
HRS00_14885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRS00_14895	COG2963	transposase activity
HRS00_14905	COG3328	transposase activity
HRS00_14925	COG0463	Glycosyl transferase, family 2
HRS00_14930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HRS00_14935	COG3959	Transketolase, thiamine diphosphate binding domain
HRS00_14940	COG4106	trans-aconitate 2-methyltransferase activity
HRS00_14945	COG2226	methyltransferase
HRS00_14975	COG1396	sequence-specific DNA binding
HRS00_14995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HRS00_15010	COG3443	Belongs to the bacterial solute-binding protein 9 family
HRS00_15015	COG1131	(ABC) transporter
HRS00_15020	COG3706	GGDEF domain
HRS00_15030	COG0784	Response regulator, receiver
HRS00_15030	COG4191	Histidine kinase
HRS00_15035	COG0840	transmembrane signaling receptor activity
HRS00_15060	COG1609	Transcriptional regulator
HRS00_15065	COG0673	inositol 2-dehydrogenase activity
HRS00_15075	COG1653	transport
HRS00_15080	COG1175	transmembrane transport
HRS00_15085	COG0395	ABC-type sugar transport system, permease component
HRS00_15090	COG3842	ATPase activity
HRS00_15095	COG0445	tRNA wobble uridine modification
HRS00_15100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRS00_15130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_15135	COG1063	alcohol dehydrogenase
HRS00_15150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15160	COG0747	negative chemotaxis
HRS00_15180	COG0577	efflux transmembrane transporter activity
HRS00_15185	COG1136	(ABC) transporter
HRS00_15190	COG2186	Transcriptional regulator
HRS00_15205	COG1175	transmembrane transport
HRS00_15210	COG0395	ABC-type sugar transport system, permease component
HRS00_15215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HRS00_15260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRS00_15275	COG0297	glycogen (starch) synthase activity
HRS00_15280	COG4106	trans-aconitate 2-methyltransferase activity
HRS00_15285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HRS00_15330	COG4702	Belongs to the UPF0303 family
HRS00_15350	COG2186	Transcriptional regulator
HRS00_15360	COG0765	amino acid transport
HRS00_15365	COG1126	abc transporter atp-binding protein
HRS00_15370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HRS00_15380	COG1228	amidohydrolase
HRS00_15390	COG1802	Transcriptional regulator
HRS00_15395	COG0747	negative chemotaxis
HRS00_15405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15415	COG0402	S-adenosylhomocysteine deaminase activity
HRS00_15420	COG0444	Belongs to the ABC transporter superfamily
HRS00_15425	COG4608	Belongs to the ABC transporter superfamily
HRS00_15440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRS00_15445	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRS00_15450	COG2080	2 iron, 2 sulfur cluster binding
HRS00_15455	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRS00_15460	COG1309	transcriptional regulator
HRS00_15475	COG0765	amino acid transport
HRS00_15480	COG1126	abc transporter atp-binding protein
HRS00_15485	COG2079	MmgE PrpD family protein
HRS00_15490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_15500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HRS00_15505	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HRS00_15515	COG0765	amino acid transport
HRS00_15520	COG0765	amino acid transport
HRS00_15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_15530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRS00_15540	COG4948	Mandelate Racemase Muconate Lactonizing
HRS00_15545	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_15550	COG1063	alcohol dehydrogenase
HRS00_15555	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HRS00_15560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HRS00_15575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15580	COG0601	transmembrane transport
HRS00_15585	COG0747	negative chemotaxis
HRS00_15595	COG4172	Belongs to the ABC transporter superfamily
HRS00_15600	COG1802	Transcriptional regulator
HRS00_15625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HRS00_15630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_15635	COG0765	amino acid transport
HRS00_15645	COG3665	Urea carboxylase-associated protein
HRS00_15660	COG0006	proline dipeptidase activity
HRS00_15675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HRS00_15680	COG1802	Transcriptional regulator
HRS00_15685	COG1984	allophanate hydrolase subunit 2
HRS00_15690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRS00_15705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_15715	COG0765	amino acid transport
HRS00_15720	COG0765	amino acid transport
HRS00_15750	COG4178	(ABC) transporter
HRS00_15770	COG0601	transmembrane transport
HRS00_15775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15780	COG0444	Belongs to the ABC transporter superfamily
HRS00_15790	COG0604	alcohol dehydrogenase
HRS00_15790	COG3321	synthase
HRS00_15800	COG1764	response to oxidative stress
HRS00_15805	COG0747	negative chemotaxis
HRS00_15810	COG0601	transmembrane transport
HRS00_15815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15825	COG0277	FAD linked oxidase domain protein
HRS00_15855	COG1902	pentaerythritol trinitrate reductase activity
HRS00_15860	COG0640	Transcriptional regulator
HRS00_15870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRS00_15895	COG1609	Transcriptional regulator
HRS00_15905	COG0583	DNA-binding transcription factor activity
HRS00_15910	COG2814	Major facilitator Superfamily
HRS00_15915	COG4774	siderophore transport
HRS00_15935	COG1473	amidohydrolase
HRS00_15940	COG4172	Belongs to the ABC transporter superfamily
HRS00_15945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_15950	COG0601	transmembrane transport
HRS00_15955	COG0747	negative chemotaxis
HRS00_15960	COG1414	Transcriptional regulator
HRS00_15975	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_15980	COG3181	Tripartite tricarboxylate transporter family receptor
HRS00_16005	COG1335	isochorismatase
HRS00_16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_16020	COG1609	Transcriptional regulator
HRS00_16025	COG2211	Major facilitator Superfamily
HRS00_16035	COG1129	ABC transporter
HRS00_16040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_16050	COG0154	amidase activity
HRS00_16065	COG3201	nicotinamide mononucleotide transporter
HRS00_16080	COG3842	ATPase activity
HRS00_16085	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRS00_16090	COG1177	transmembrane transport
HRS00_16105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HRS00_16125	COG2211	Major facilitator Superfamily
HRS00_16145	COG2814	Major facilitator Superfamily
HRS00_16150	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRS00_16175	COG0431	NADPH-dependent FMN reductase
HRS00_16175	COG1053	succinate dehydrogenase
HRS00_16175	COG3976	FMN-binding domain protein
HRS00_16190	COG1137	ATPase activity
HRS00_16210	COG0066	3-isopropylmalate dehydratase activity
HRS00_16215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HRS00_16250	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HRS00_16265	COG0584	glycerophosphoryl diester phosphodiesterase
HRS00_16270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_16280	COG4608	Belongs to the ABC transporter superfamily
HRS00_16290	COG0747	negative chemotaxis
HRS00_16305	COG3842	ATPase activity
HRS00_16310	COG1175	transmembrane transport
HRS00_16325	COG1609	Transcriptional regulator
HRS00_16335	COG2814	Major facilitator Superfamily
HRS00_16350	COG1879	ABC-type sugar transport system periplasmic component
HRS00_16355	COG1129	ABC transporter
HRS00_16360	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_16370	COG3386	PFAM SMP-30 Gluconolaconase
HRS00_16375	COG1120	ATPase activity
HRS00_16385	COG4774	siderophore transport
HRS00_16405	COG3842	ATPase activity
HRS00_16410	COG0395	ABC-type sugar transport system, permease component
HRS00_16415	COG1175	transmembrane transport
HRS00_16420	COG1653	transport
HRS00_16430	COG0673	inositol 2-dehydrogenase activity
HRS00_16450	COG0683	leucine binding
HRS00_16460	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRS00_16480	COG0745	RESPONSE REGULATOR receiver
HRS00_16485	COG1840	ABC-type Fe3 transport system, periplasmic component
HRS00_16490	COG1840	ABC-type Fe3 transport system, periplasmic component
HRS00_16500	COG3842	ATPase activity
HRS00_16515	COG4178	(ABC) transporter
HRS00_16530	COG5001	Diguanylate cyclase
HRS00_16545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HRS00_16555	COG0438	transferase activity, transferring glycosyl groups
HRS00_16570	COG0438	transferase activity, transferring glycosyl groups
HRS00_16580	COG0489	protein tyrosine kinase activity
HRS00_16580	COG3206	protein involved in exopolysaccharide biosynthesis
HRS00_16605	COG0659	secondary active sulfate transmembrane transporter activity
HRS00_16625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HRS00_16630	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HRS00_16635	COG2080	2 iron, 2 sulfur cluster binding
HRS00_16650	COG3608	succinylglutamate desuccinylase aspartoacylase
HRS00_16650	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HRS00_16660	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRS00_16660	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HRS00_16665	COG0523	cobalamin synthesis protein
HRS00_16670	COG1940	carbohydrate kinase activity
HRS00_16675	COG1473	amidohydrolase
HRS00_16680	COG1126	abc transporter atp-binding protein
HRS00_16685	COG0765	amino acid transport
HRS00_16705	COG0747	negative chemotaxis
HRS00_16710	COG0601	transmembrane transport
HRS00_16720	COG3964	amidohydrolase
HRS00_16735	COG1921	L-seryl-tRNASec selenium transferase activity
HRS00_16740	COG4172	Belongs to the ABC transporter superfamily
HRS00_16750	COG4529	Protein conserved in bacteria
HRS00_16775	COG1175	transmembrane transport
HRS00_16780	COG0395	ABC-type sugar transport system, permease component
HRS00_16810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HRS00_16815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_16825	COG1653	transport
HRS00_16830	COG1175	transmembrane transport
HRS00_16835	COG0395	ABC-type sugar transport system, permease component
HRS00_16840	COG3842	ATPase activity
HRS00_16850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRS00_16880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HRS00_16885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HRS00_16895	COG4974	Belongs to the 'phage' integrase family
HRS00_16900	COG0825	malonyl-CoA metabolic process
HRS00_16905	COG2205	protein histidine kinase activity
HRS00_16915	COG2204	response regulator
HRS00_16920	COG1376	ErfK ybiS ycfS ynhG family protein
HRS00_16930	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_16935	COG2094	Belongs to the DNA glycosylase MPG family
HRS00_16940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRS00_16945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HRS00_16955	COG1802	Transcriptional regulator
HRS00_16960	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_16970	COG3842	ATPase activity
HRS00_16975	COG1176	ABC-type spermidine putrescine transport system, permease component I
HRS00_16980	COG1177	transmembrane transport
HRS00_16995	COG0628	permease
HRS00_17005	COG1686	Belongs to the peptidase S11 family
HRS00_17010	COG0673	inositol 2-dehydrogenase activity
HRS00_17015	COG4221	oxidoreductase activity
HRS00_17025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HRS00_17035	COG0539	negative regulation of cytoplasmic translation
HRS00_17040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HRS00_17060	COG2890	protein-(glutamine-N5) methyltransferase activity
HRS00_17065	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HRS00_17075	COG0527	aspartate kinase activity
HRS00_17080	COG0513	Belongs to the DEAD box helicase family
HRS00_17090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HRS00_17100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HRS00_17105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRS00_17115	COG2226	methyltransferase
HRS00_17125	COG1366	Belongs to the anti-sigma-factor antagonist family
HRS00_17125	COG2202	Pas domain
HRS00_17155	COG0673	inositol 2-dehydrogenase activity
HRS00_17185	COG1024	Enoyl-CoA hydratase
HRS00_17185	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRS00_17205	COG1832	CoA-binding protein
HRS00_17215	COG0583	DNA-binding transcription factor activity
HRS00_17235	COG0559	Belongs to the binding-protein-dependent transport system permease family
HRS00_17245	COG1064	alcohol dehydrogenase
HRS00_17260	COG0745	RESPONSE REGULATOR receiver
HRS00_17275	COG1162	GTPase activity
HRS00_17300	COG1595	DNA-templated transcription, initiation
HRS00_17325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_17330	COG4605	iron ion homeostasis
HRS00_17335	COG4604	ABC transporter, ATP-binding protein
HRS00_17340	COG2116	formate transmembrane transporter activity
HRS00_17365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HRS00_17365	COG2010	Cytochrome c
HRS00_17370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HRS00_17410	COG0739	heme binding
HRS00_17410	COG0741	lytic transglycosylase activity
HRS00_17410	COG1196	nuclear chromosome segregation
HRS00_17415	COG0542	response to heat
HRS00_17420	COG2226	methyltransferase
HRS00_17435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_17440	COG1120	ATPase activity
HRS00_17450	COG1999	signal sequence binding
HRS00_17460	COG2217	Heavy metal translocating P-type atpase
HRS00_17475	COG3842	ATPase activity
HRS00_17480	COG1175	transmembrane transport
HRS00_17485	COG0395	ABC-type sugar transport system, permease component
HRS00_17500	COG2076	Multidrug Resistance protein
HRS00_17510	COG1647	Serine aminopeptidase, S33
HRS00_17520	COG2076	Multidrug Resistance protein
HRS00_17530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HRS00_17545	COG0745	RESPONSE REGULATOR receiver
HRS00_17560	COG1737	Transcriptional regulator
HRS00_17565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_17570	COG1129	ABC transporter
HRS00_17590	COG0395	ABC-type sugar transport system, permease component
HRS00_17595	COG1175	transmembrane transport
HRS00_17605	COG3842	ATPase activity
HRS00_17615	COG1486	melibiose metabolic process
HRS00_17620	COG4172	Belongs to the ABC transporter superfamily
HRS00_17625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_17630	COG0601	transmembrane transport
HRS00_17635	COG0747	negative chemotaxis
HRS00_17640	COG1486	melibiose metabolic process
HRS00_17650	COG3842	ATPase activity
HRS00_17655	COG0395	ABC-type sugar transport system, permease component
HRS00_17660	COG1175	transmembrane transport
HRS00_17670	COG1802	Transcriptional regulator
HRS00_17680	COG1082	Xylose isomerase domain protein TIM barrel
HRS00_17690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRS00_17700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_17705	COG1116	anion transmembrane transporter activity
HRS00_17710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_17720	COG3842	ATPase activity
HRS00_17730	COG0657	acetylesterase activity
HRS00_17740	COG1175	transmembrane transport
HRS00_17745	COG0395	ABC-type sugar transport system, permease component
HRS00_17760	COG0673	inositol 2-dehydrogenase activity
HRS00_17770	COG3684	Belongs to the aldolase LacD family
HRS00_17780	COG0765	amino acid transport
HRS00_17795	COG1126	abc transporter atp-binding protein
HRS00_17800	COG2186	Transcriptional regulator
HRS00_17810	COG1312	Catalyzes the dehydration of D-mannonate
HRS00_17820	COG3842	ATPase activity
HRS00_17825	COG0395	ABC-type sugar transport system, permease component
HRS00_17830	COG1175	transmembrane transport
HRS00_17835	COG1653	transport
HRS00_17845	COG0410	ABC transporter
HRS00_17850	COG1137	ATPase activity
HRS00_17865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HRS00_17870	COG1309	transcriptional regulator
HRS00_17875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HRS00_17885	COG1053	succinate dehydrogenase
HRS00_17885	COG3976	FMN-binding domain protein
HRS00_17885	COG0431	NADPH-dependent FMN reductase
HRS00_17890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HRS00_17900	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_17905	COG1414	Transcriptional regulator
HRS00_17940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRS00_17950	COG1177	transmembrane transport
HRS00_17965	COG3842	ATPase activity
HRS00_17975	COG0765	amino acid transport
HRS00_17990	COG2354	Protein conserved in bacteria
HRS00_17995	COG1597	lipid kinase activity
HRS00_18000	COG0598	Magnesium transport protein CorA
HRS00_18005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRS00_18020	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_18025	COG0584	glycerophosphoryl diester phosphodiesterase
HRS00_18035	COG4149	molybdate abc transporter
HRS00_18040	COG3842	ATPase activity
HRS00_18080	COG0583	DNA-binding transcription factor activity
HRS00_18085	COG0657	acetylesterase activity
HRS00_18115	COG3920	Histidine kinase
HRS00_18135	COG1116	anion transmembrane transporter activity
HRS00_18155	COG0402	S-adenosylhomocysteine deaminase activity
HRS00_18180	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_18200	COG0798	PFAM Bile acid sodium symporter
HRS00_18210	COG0431	NADPH-dependent FMN reductase
HRS00_18220	COG3842	ATPase activity
HRS00_18225	COG0395	ABC-type sugar transport system, permease component
HRS00_18240	COG1233	COG1233 Phytoene dehydrogenase and related
HRS00_18245	COG1609	Transcriptional regulator
HRS00_18260	COG3177	Filamentation induced by cAMP protein fic
HRS00_18270	COG2079	MmgE PrpD family protein
HRS00_18280	COG0583	DNA-binding transcription factor activity
HRS00_18285	COG0601	transmembrane transport
HRS00_18290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_18295	COG4172	Belongs to the ABC transporter superfamily
HRS00_18305	COG0747	negative chemotaxis
HRS00_18310	COG1473	amidohydrolase
HRS00_18335	COG3395	kinase activity
HRS00_18345	COG1454	alcohol dehydrogenase
HRS00_18350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HRS00_18360	COG0747	negative chemotaxis
HRS00_18365	COG0601	transmembrane transport
HRS00_18370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_18380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_18390	COG3077	Addiction module antitoxin, RelB DinJ family
HRS00_18405	COG1733	regulation of RNA biosynthetic process
HRS00_18410	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_18435	COG1794	racemase activity, acting on amino acids and derivatives
HRS00_18490	COG0667	Aldo Keto reductase
HRS00_18505	COG0598	Magnesium transport protein CorA
HRS00_18510	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_18520	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_18530	COG0708	Exodeoxyribonuclease III
HRS00_18565	COG0210	DNA helicase
HRS00_18575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HRS00_18580	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HRS00_18615	COG1780	Probably involved in ribonucleotide reductase function
HRS00_18620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HRS00_18655	COG1271	oxidase subunit
HRS00_18660	COG1294	oxidase, subunit
HRS00_18670	COG0583	DNA-binding transcription factor activity
HRS00_18685	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HRS00_18720	COG0702	epimerase
HRS00_18735	COG1017	nitric oxide dioxygenase activity
HRS00_18735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRS00_18740	COG0625	glutathione transferase activity
HRS00_18760	COG0583	DNA-binding transcription factor activity
HRS00_18770	COG1309	transcriptional regulator
HRS00_18785	COG0596	Alpha beta hydrolase
HRS00_18800	COG4948	Mandelate Racemase Muconate Lactonizing
HRS00_18805	COG2188	Transcriptional regulator
HRS00_18815	COG1129	ABC transporter
HRS00_18825	COG2017	converts alpha-aldose to the beta-anomer
HRS00_18830	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_18845	COG0840	transmembrane signaling receptor activity
HRS00_18850	COG0583	DNA-binding transcription factor activity
HRS00_18855	COG2828	Protein conserved in bacteria
HRS00_18870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HRS00_18875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HRS00_18890	COG1309	transcriptional regulator
HRS00_18895	COG2814	Major facilitator Superfamily
HRS00_18905	COG0778	Nitroreductase
HRS00_18930	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HRS00_18980	COG1129	ABC transporter
HRS00_18985	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_18990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_19005	COG1082	Xylose isomerase domain protein TIM barrel
HRS00_19015	COG1501	Belongs to the glycosyl hydrolase 31 family
HRS00_19020	COG0395	ABC-type sugar transport system, permease component
HRS00_19025	COG1175	transmembrane transport
HRS00_19030	COG1653	transport
HRS00_19035	COG3842	ATPase activity
HRS00_19040	COG2188	Transcriptional regulator
HRS00_19050	COG4989	oxidoreductase activity
HRS00_19060	COG2855	membrane
HRS00_19065	COG0583	DNA-binding transcription factor activity
HRS00_19075	COG3920	Histidine kinase
HRS00_19095	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_19100	COG1129	ABC transporter
HRS00_19110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_19115	COG3959	Transketolase, thiamine diphosphate binding domain
HRS00_19120	COG3958	Transketolase
HRS00_19125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HRS00_19130	COG2390	Transcriptional regulator
HRS00_19140	COG2203	Gaf domain
HRS00_19140	COG5001	Diguanylate cyclase
HRS00_19140	COG3706	GGDEF domain
HRS00_19140	COG4251	negative regulation of phosphorylation
HRS00_19145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRS00_19155	COG2826	transposase and inactivated derivatives, IS30 family
HRS00_19160	COG0778	Nitroreductase
HRS00_19165	COG2267	carboxylic ester hydrolase activity
HRS00_19170	COG0251	oxidation-reduction process
HRS00_19175	COG1335	isochorismatase
HRS00_19180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_19190	COG0438	transferase activity, transferring glycosyl groups
HRS00_19225	COG0489	protein tyrosine kinase activity
HRS00_19225	COG3206	protein involved in exopolysaccharide biosynthesis
HRS00_19235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HRS00_19245	COG1192	Involved in chromosome partitioning
HRS00_19250	COG1475	DNA binding
HRS00_19255	COG1414	Transcriptional regulator
HRS00_19280	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HRS00_19310	COG1653	transport
HRS00_19330	COG0411	ABC transporter
HRS00_19355	COG1846	Transcriptional regulator
HRS00_19365	COG0179	Fumarylacetoacetate (FAA) hydrolase
HRS00_19385	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_19395	COG0277	FAD linked oxidase domain protein
HRS00_19400	COG0436	Aminotransferase
HRS00_19410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HRS00_19415	COG4608	Belongs to the ABC transporter superfamily
HRS00_19425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_19430	COG0601	transmembrane transport
HRS00_19435	COG0747	negative chemotaxis
HRS00_19445	COG0765	amino acid transport
HRS00_19470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_19475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HRS00_19490	COG2814	Major facilitator Superfamily
HRS00_19500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_19545	COG0747	negative chemotaxis
HRS00_19560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_19575	COG1846	Transcriptional regulator
HRS00_19580	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HRS00_19590	COG1309	transcriptional regulator
HRS00_19595	COG0300	oxidoreductase activity
HRS00_19605	COG3483	tryptophan 2,3-dioxygenase activity
HRS00_19610	COG1802	Transcriptional regulator
HRS00_19620	COG0318	PFAM AMP-dependent synthetase and ligase
HRS00_19650	COG0165	Argininosuccinate lyase
HRS00_19655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HRS00_19660	COG1250	3-hydroxyacyl-CoA dehydrogenase
HRS00_19670	COG2086	electron transfer activity
HRS00_19690	COG0300	oxidoreductase activity
HRS00_19700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HRS00_19730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HRS00_19740	COG3685	Protein conserved in bacteria
HRS00_19745	COG0517	IMP dehydrogenase activity
HRS00_19745	COG4175	Glycine betaine
HRS00_19750	COG4176	ABC-type proline glycine betaine transport system permease component
HRS00_19760	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HRS00_19770	COG0446	pyridine nucleotide-disulphide oxidoreductase
HRS00_19770	COG1902	pentaerythritol trinitrate reductase activity
HRS00_19775	COG1960	acyl-CoA dehydrogenase activity
HRS00_19825	COG1396	sequence-specific DNA binding
HRS00_19830	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HRS00_19835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HRS00_19850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HRS00_19855	COG2226	methyltransferase
HRS00_19860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HRS00_19865	COG0287	Prephenate dehydrogenase
HRS00_19875	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HRS00_19895	COG2884	Cell division ATP-binding protein ftsE
HRS00_19920	COG2124	cytochrome p450
HRS00_19925	COG1309	transcriptional regulator
HRS00_19940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRS00_19950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HRS00_19955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HRS00_19960	COG2188	Transcriptional regulator
HRS00_19965	COG2971	BadF BadG BcrA BcrD
HRS00_19970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HRS00_19975	COG1653	transport
HRS00_19980	COG1175	transmembrane transport
HRS00_19985	COG0395	ABC-type sugar transport system, permease component
HRS00_19990	COG0673	inositol 2-dehydrogenase activity
HRS00_20000	COG3142	Participates in the control of copper homeostasis
HRS00_20010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRS00_20015	COG0657	acetylesterase activity
HRS00_20035	COG3237	CsbD-like
HRS00_20040	COG2197	response regulator
HRS00_20045	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_20050	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_20065	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_20075	COG1879	ABC-type sugar transport system periplasmic component
HRS00_20085	COG2188	Transcriptional regulator
HRS00_20090	COG3624	Phosphonate C-P lyase system protein PhnG
HRS00_20095	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HRS00_20100	COG3626	phosphonate metabolism
HRS00_20105	COG3627	carbon phosphorus lyase activity
HRS00_20110	COG4107	phosphonate C-P lyase system protein PhnK
HRS00_20115	COG4778	phosphonate C-P lyase system protein PhnL
HRS00_20125	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HRS00_20130	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HRS00_20135	COG3639	organic phosphonate transmembrane transporter activity
HRS00_20140	COG3454	Phosphonate metabolism
HRS00_20150	COG0010	Belongs to the arginase family
HRS00_20160	COG0697	spore germination
HRS00_20195	COG0673	inositol 2-dehydrogenase activity
HRS00_20200	COG1309	transcriptional regulator
HRS00_20205	COG1653	transport
HRS00_20210	COG1175	transmembrane transport
HRS00_20215	COG0395	ABC-type sugar transport system, permease component
HRS00_20225	COG0673	inositol 2-dehydrogenase activity
HRS00_20230	COG3842	ATPase activity
HRS00_20235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HRS00_20240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HRS00_20245	COG0277	FAD linked oxidase domain protein
HRS00_20250	COG2186	Transcriptional regulator
HRS00_20260	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HRS00_20265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRS00_20270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRS00_20280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HRS00_20295	COG1309	transcriptional regulator
HRS00_20300	COG1686	Belongs to the peptidase S11 family
HRS00_20330	COG2835	tetraacyldisaccharide 4'-kinase activity
HRS00_20340	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HRS00_20345	COG2373	Large extracellular alpha-helical protein
HRS00_20350	COG4953	penicillin-binding protein 1C
HRS00_20355	COG0189	ligase activity
HRS00_20385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HRS00_20395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HRS00_20440	COG2207	Transcriptional regulator
HRS00_20480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HRS00_20530	COG1192	Involved in chromosome partitioning
HRS00_20535	COG2201	protein-glutamate methylesterase activity
HRS00_20540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HRS00_20545	COG0835	chemotaxis
HRS00_20550	COG0840	transmembrane signaling receptor activity
HRS00_20555	COG0840	transmembrane signaling receptor activity
HRS00_20560	COG0840	transmembrane signaling receptor activity
HRS00_20565	COG0835	chemotaxis
HRS00_20590	COG1175	transmembrane transport
HRS00_20595	COG0395	ABC-type sugar transport system, permease component
HRS00_20610	COG0673	inositol 2-dehydrogenase activity
HRS00_20630	COG0425	Belongs to the sulfur carrier protein TusA family
HRS00_20630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HRS00_20635	COG0602	queuosine metabolic process
HRS00_20640	COG0720	synthase
HRS00_20645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HRS00_20655	COG1120	ATPase activity
HRS00_20660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_20675	COG2207	Transcriptional regulator
HRS00_20690	COG1012	belongs to the aldehyde dehydrogenase family
HRS00_20700	COG1120	ATPase activity
HRS00_20705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_20710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HRS00_20725	COG2186	Transcriptional regulator
HRS00_20730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HRS00_20740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HRS00_20745	COG1063	alcohol dehydrogenase
HRS00_20750	COG1312	Catalyzes the dehydration of D-mannonate
HRS00_20755	COG0246	Mannitol dehydrogenase
HRS00_20765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HRS00_20775	COG0288	reversible hydration of carbon dioxide
HRS00_20780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HRS00_20785	COG1802	Transcriptional regulator
HRS00_20790	COG1914	H( )-stimulated, divalent metal cation uptake system
HRS00_20795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HRS00_20800	COG4336	lyase activity
HRS00_20805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HRS00_20810	COG4770	biotin carboxylase activity
HRS00_20820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HRS00_20820	COG1082	Xylose isomerase domain protein TIM barrel
HRS00_20830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HRS00_20835	COG1126	abc transporter atp-binding protein
HRS00_20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_20845	COG0765	amino acid transport
HRS00_20850	COG0765	amino acid transport
HRS00_20855	COG3046	protein related to deoxyribodipyrimidine photolyase
HRS00_20880	COG2205	protein histidine kinase activity
HRS00_20885	COG0745	RESPONSE REGULATOR receiver
HRS00_20985	COG4191	Histidine kinase
HRS00_20985	COG0784	Response regulator, receiver
HRS00_20990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HRS00_21025	COG0673	inositol 2-dehydrogenase activity
HRS00_21035	COG1063	alcohol dehydrogenase
HRS00_21040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HRS00_21045	COG0747	negative chemotaxis
HRS00_21050	COG0601	transmembrane transport
HRS00_21055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_21060	COG0444	Belongs to the ABC transporter superfamily
HRS00_21065	COG4608	Belongs to the ABC transporter superfamily
HRS00_21090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_21095	COG0601	transmembrane transport
HRS00_21100	COG0747	negative chemotaxis
HRS00_21120	COG1442	glycosyl transferase family 8
HRS00_21125	COG0653	protein targeting
HRS00_21130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HRS00_21135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HRS00_21145	COG0494	nUDIX hydrolase
HRS00_21160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRS00_21185	COG5001	Diguanylate cyclase
HRS00_21190	COG2264	protein methyltransferase activity
HRS00_21195	COG4608	Belongs to the ABC transporter superfamily
HRS00_21200	COG0444	Belongs to the ABC transporter superfamily
HRS00_21205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_21210	COG0601	transmembrane transport
HRS00_21215	COG2186	Transcriptional regulator
HRS00_21225	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HRS00_21230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HRS00_21260	COG2194	sulfuric ester hydrolase activity
HRS00_21275	COG2133	pyrroloquinoline quinone binding
HRS00_21285	COG0500	methyltransferase
HRS00_21290	COG0564	pseudouridine synthase activity
HRS00_21305	COG0784	Response regulator, receiver
HRS00_21305	COG4191	Histidine kinase
HRS00_21310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HRS00_21315	COG3206	protein involved in exopolysaccharide biosynthesis
HRS00_21315	COG0489	protein tyrosine kinase activity
HRS00_21320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HRS00_21325	COG1215	transferase activity, transferring glycosyl groups
HRS00_21330	COG1215	transferase activity, transferring glycosyl groups
HRS00_21335	COG1215	transferase activity, transferring glycosyl groups
HRS00_21340	COG0438	transferase activity, transferring glycosyl groups
HRS00_21345	COG2273	Hydrolase Family 16
HRS00_21350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HRS00_21355	COG2244	polysaccharide biosynthetic process
HRS00_21360	COG0463	Glycosyl transferase, family 2
HRS00_21365	COG2327	Polysaccharide pyruvyl transferase
HRS00_21370	COG1215	transferase activity, transferring glycosyl groups
HRS00_21385	COG1609	Transcriptional regulator
HRS00_21390	COG1129	ABC transporter
HRS00_21395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_21400	COG1879	ABC-type sugar transport system periplasmic component
HRS00_21405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_21410	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HRS00_21415	COG0281	malic enzyme
HRS00_21415	COG0280	phosphate acetyltransferase
HRS00_21435	COG2137	regulation of response to DNA damage stimulus
HRS00_21450	COG2942	2-epimerase
HRS00_21460	COG1215	transferase activity, transferring glycosyl groups
HRS00_21480	COG1959	2 iron, 2 sulfur cluster binding
HRS00_21495	COG1301	dicarboxylic acid transport
HRS00_21500	COG4191	Histidine kinase
HRS00_21505	COG2204	response regulator
HRS00_21535	COG3842	ATPase activity
HRS00_21545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HRS00_21550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HRS00_21555	COG1522	sequence-specific DNA binding
HRS00_21560	COG0351	phosphomethylpyrimidine kinase
HRS00_21565	COG0352	thiamine-phosphate diphosphorylase activity
HRS00_21570	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HRS00_21575	COG0673	inositol 2-dehydrogenase activity
HRS00_21615	COG4770	biotin carboxylase activity
HRS00_21620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HRS00_21625	COG1126	abc transporter atp-binding protein
HRS00_21630	COG0765	amino acid transport
HRS00_21635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HRS00_21640	COG0850	regulation of cytokinetic process
HRS00_21645	COG2894	cell division
HRS00_21650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HRS00_21655	COG2223	nitrite transmembrane transporter activity
HRS00_21665	COG0583	DNA-binding transcription factor activity
HRS00_21675	COG3119	arylsulfatase activity
HRS00_21695	COG0515	serine threonine protein kinase
HRS00_21790	COG3842	ATPase activity
HRS00_21795	COG0395	ABC-type sugar transport system, permease component
HRS00_21800	COG1175	transmembrane transport
HRS00_21815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HRS00_21820	COG1674	ftsk spoiiie
HRS00_21825	COG3300	MHYT domain
HRS00_21825	COG5001	Diguanylate cyclase
HRS00_21835	COG3257	ureidoglycine aminohydrolase activity
HRS00_21840	COG5001	Diguanylate cyclase
HRS00_21840	COG5002	protein histidine kinase activity
HRS00_21840	COG3447	MASE1 domain protein
HRS00_21845	COG2273	Hydrolase Family 16
HRS00_21845	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HRS00_21855	COG0372	Belongs to the citrate synthase family
HRS00_21860	COG0372	Belongs to the citrate synthase family
HRS00_21875	COG1024	Enoyl-CoA hydratase
HRS00_21890	COG1960	acyl-CoA dehydrogenase activity
HRS00_21915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HRS00_21925	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HRS00_21930	COG5001	Diguanylate cyclase
HRS00_21930	COG3300	MHYT domain
HRS00_21945	COG0183	Belongs to the thiolase family
HRS00_21950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HRS00_21960	COG1414	Transcriptional regulator
HRS00_21975	COG0583	DNA-binding transcription factor activity
HRS00_21990	COG3485	protocatechuate 3,4-dioxygenase
HRS00_21995	COG3485	protocatechuate 3,4-dioxygenase
HRS00_22000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HRS00_22010	COG0693	protein deglycase activity
HRS00_22015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HRS00_22020	COG1596	polysaccharide export
HRS00_22025	COG3307	-O-antigen
HRS00_22040	COG0587	DNA-directed DNA polymerase activity
HRS00_22045	COG2186	Transcriptional regulator
HRS00_22050	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_22055	COG1172	Belongs to the binding-protein-dependent transport system permease family
HRS00_22060	COG1129	ABC transporter
HRS00_22065	COG1879	ABC-type sugar transport system periplasmic component
HRS00_22070	COG0129	dihydroxy-acid dehydratase activity
HRS00_22085	COG3145	DNA-N1-methyladenine dioxygenase activity
HRS00_22115	COG2197	response regulator
HRS00_22135	COG0488	(ABC) transporter
HRS00_22145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HRS00_22150	COG3962	Belongs to the TPP enzyme family
HRS00_22160	COG3718	enzyme involved in inositol metabolism
HRS00_22165	COG0450	alkyl hydroperoxide reductase
HRS00_22170	COG5265	(ABC) transporter
HRS00_22175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HRS00_22195	COG0395	ABC-type sugar transport system, permease component
HRS00_22205	COG3842	ATPase activity
HRS00_22210	COG3842	ATPase activity
HRS00_22225	COG4166	transmembrane transport
HRS00_22230	COG0601	transmembrane transport
HRS00_22235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_22240	COG4172	Belongs to the ABC transporter superfamily
HRS00_22250	COG3300	MHYT domain
HRS00_22250	COG5001	Diguanylate cyclase
HRS00_22260	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_22290	COG0477	Major facilitator Superfamily
HRS00_22315	COG0714	Associated with various cellular activities
HRS00_22320	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HRS00_22330	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HRS00_22335	COG4715	Zinc finger, swim domain protein
HRS00_22415	COG1192	Involved in chromosome partitioning
HRS00_22420	COG1475	DNA binding
HRS00_22425	COG0640	Transcriptional regulator
HRS00_22465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HRS00_22490	COG2826	transposase and inactivated derivatives, IS30 family
HRS00_22505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HRS00_22510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRS00_22565	COG0583	DNA-binding transcription factor activity
HRS00_22575	COG0039	L-malate dehydrogenase activity
HRS00_22585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HRS00_22590	COG0038	chloride channel
HRS00_22720	COG3077	Addiction module antitoxin, RelB DinJ family
HRS00_22775	COG2433	Pfam Transposase IS66
HRS00_22780	COG3436	PFAM IS66 Orf2 family protein
HRS00_22810	COG0840	transmembrane signaling receptor activity
HRS00_22815	COG0835	chemotaxis
HRS00_22820	COG4691	Plasmid stability protein
HRS00_22825	COG1487	ribonuclease activity
HRS00_22835	COG2202	Pas domain
HRS00_22835	COG3920	Histidine kinase
HRS00_22855	COG0668	transmembrane transport
HRS00_22860	COG1295	ribonuclease BN
HRS00_22865	COG2972	Histidine kinase
HRS00_22865	COG0840	transmembrane signaling receptor activity
HRS00_22870	COG5001	Diguanylate cyclase
HRS00_22885	COG0625	glutathione transferase activity
HRS00_22890	COG1017	nitric oxide dioxygenase activity
HRS00_22890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HRS00_22905	COG0702	epimerase
HRS00_22935	COG3177	Filamentation induced by cAMP protein fic
HRS00_22945	COG0840	transmembrane signaling receptor activity
HRS00_22955	COG2972	Histidine kinase
HRS00_22955	COG0840	transmembrane signaling receptor activity
HRS00_22980	COG1793	dna ligase
HRS00_22995	COG0587	DNA-directed DNA polymerase activity
HRS00_23000	COG1278	Cold shock
HRS00_23040	COG1475	DNA binding
HRS00_23065	COG5489	Protein of unknown function (DUF736)
HRS00_23070	COG0776	regulation of translation
HRS00_23075	COG3831	ATPase activity
HRS00_23135	COG4172	Belongs to the ABC transporter superfamily
HRS00_23140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_23180	COG0747	negative chemotaxis
HRS00_23190	COG0483	inositol monophosphate 1-phosphatase activity
HRS00_23200	COG3842	ATPase activity
HRS00_23210	COG1175	transmembrane transport
HRS00_23220	COG1846	Transcriptional regulator
HRS00_23220	COG1940	carbohydrate kinase activity
HRS00_23245	COG0584	glycerophosphoryl diester phosphodiesterase
HRS00_23250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_23315	COG1177	transmembrane transport
HRS00_23325	COG3842	ATPase activity
HRS00_23335	COG0154	amidase activity
HRS00_23350	COG1840	ABC-type Fe3 transport system, periplasmic component
HRS00_23370	COG3701	Conjugal transfer protein
HRS00_23375	COG3846	protein secretion by the type IV secretion system
HRS00_23385	COG5314	conjugation
HRS00_23390	COG3451	type IV secretory pathway VirB4
HRS00_23405	COG4962	Type ii secretion system protein e
HRS00_23415	COG1192	Involved in chromosome partitioning
HRS00_23420	COG1475	DNA binding
HRS00_23425	COG0640	Transcriptional regulator
HRS00_23445	COG2885	chlorophyll binding
HRS00_23500	COG3093	addiction module antidote protein HigA
HRS00_23540	COG2205	protein histidine kinase activity
HRS00_23555	COG0671	phosphoesterase, PA-phosphatase related
HRS00_23565	COG2194	sulfuric ester hydrolase activity
HRS00_23570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HRS00_23575	COG0390	transport system, permease component
HRS00_23580	COG0840	transmembrane signaling receptor activity
HRS00_23590	COG2084	Dehydrogenase
HRS00_23595	COG3622	Belongs to the hyi family
HRS00_23605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HRS00_23610	COG0601	transmembrane transport
HRS00_23620	COG0747	negative chemotaxis
HRS00_23625	COG1609	Transcriptional regulator
HRS00_23635	COG3609	addiction module antidote protein, CC2985 family
HRS00_23645	COG3706	GGDEF domain
HRS00_23650	COG0784	Response regulator, receiver
HRS00_23650	COG4191	Histidine kinase
HRS00_23655	COG2202	Pas domain
HRS00_23655	COG3920	Histidine kinase
HRS00_23660	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HRS00_23665	COG0784	Response regulator, receiver
HRS00_23665	COG4191	Histidine kinase
HRS00_23725	COG5001	Diguanylate cyclase
HRS00_23725	COG2203	Gaf domain
HRS00_23725	COG4251	negative regulation of phosphorylation
HRS00_23725	COG3706	GGDEF domain
HRS00_23735	COG3588	fructose-bisphosphate aldolase
HRS00_23765	COG4191	Histidine kinase
HRS00_23770	COG4566	intracellular signal transduction
HRS00_23810	COG0251	oxidation-reduction process
HRS00_23815	COG1414	Transcriptional regulator
HRS00_23830	COG0587	DNA-directed DNA polymerase activity
HRS00_23845	COG1793	dna ligase
HRS00_23860	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HRS00_23880	COG0583	DNA-binding transcription factor activity
HRS00_23900	COG4977	sequence-specific DNA binding
HRS00_23920	COG1733	regulation of RNA biosynthetic process
HRS00_23925	COG0583	DNA-binding transcription factor activity
HRS00_23930	COG1028	Short-chain dehydrogenase reductase Sdr
HRS00_23955	COG1196	nuclear chromosome segregation